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gamma-Fagarine

AlkaPlorer ID: AK003734

Synonym: 'Furo2,3-bquinoline-4,8-diol; OH-form, Di-Me ether', 'SMR000137321', 'MLS000532362', 'gamma-Fagarine', '4,8-Dimethoxyfuro2,3-bquinoline', 'MLSMR', 'γ-Fagarine', 'ConMedNP.3144', '4,8-dimethoxyfuro2,3-bquinoline', 'MLS001048993', 'Fagarine'

IUPAC Name: 4,8-dimethoxyfuro[2,3-b]quinoline

Structure

SMILES: COC1=C2C=CC=C(OC)C2=NC2=C1C=CO2

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InChI: InChI=1S/C13H11NO3/c1-15-10-5-3-4-8-11(10)14-13-9(6-7-17-13)12(8)16-2/h3-7H,1-2H3

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InChIKey: KFBCTNNQFGONHB-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Zanthoxylum avicennae Zanthoxylum Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 229.235

TPSA？: 44.49

MolLogP？: 2.998200000000001

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Potency 15848.9 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 28183.8 nM None
Homo sapiens Acetylcholinesterase IC50 nan None 10.1007/s00044-011-9581-9
Homo sapiens Acetylcholinesterase Inhibition 24.3 % 10.1007/s00044-011-9581-9
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 35481.3 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 20596.2 nM None
Homo sapiens Breast cancer type 1 susceptibility protein Potency 25118.9 nM None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 11220.2 nM None
Homo sapiens HepG2 IC50 160000.0 nM 10.1016/j.ejmech.2011.10.047
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 28183.8 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 31622.8 nM None
Homo sapiens microRNA 21 Potency 18492.7 nM None
Homo sapiens Muscleblind-like protein 1 Potency 39810.7 nM None
Homo sapiens Raji Activity 60.0 % 10.1021/np0400611
Homo sapiens Raji Activity 80.0 % 10.1021/np0400611
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 5850.0 nM 10.1016/j.ejmech.2021.113220
Influenza A virus Nonstructural protein 1 Potency 3981.1 nM None
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 30.0 ug.mL-1 10.1021/np700719e
Photinus pyralis Luciferin 4-monooxygenase Potency 26854.5 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 22387.2 nM None
Sus scrofa Trypsin AC50 9778.0 nM None
None Neutrophil IC50 100000.0 nM 10.1021/np070186g
None NON-PROTEIN TARGET IC50 7.17 ug.mL-1 10.1021/np800689b
None NON-PROTEIN TARGET IC50 31310.0 nM 10.1021/np070594k
None NON-PROTEIN TARGET IC50 50000.0 nM 10.1021/np070594k
None NON-PROTEIN TARGET Inhibition 19.1 % 10.1021/np800689b
None Unchecked Activity 15.4 % 10.1021/np0400611
None Unchecked Activity 38.2 % 10.1021/np0400611
None Unchecked Activity 77.7 % 10.1021/np0400611
None Unchecked Activity 100.0 % 10.1021/np0400611
None Unchecked Potency 130.0 nM None
None Unchecked Potency 29092.9 nM None

Metabolism Information