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Kanamycin

AlkaPlorer ID: AK003750

Synonym: None

IUPAC Name: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol

Structure

SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O

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InChI: InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1

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InChIKey: SBUJHOSQTJFQJX-NOAMYHISSA-N

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Properties Information

Molecule Weight: 484.50300000000016

TPSA？: 282.61000000000007

MolLogP？: -7.2914000000000065

Number of H-Donors: 11

Number of H-Acceptors: 15

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii EC50 16000.0 nM 10.1016/j.bmcl.2016.04.089
Acinetobacter baumannii Acinetobacter baumannii MBC 1.6 umol/L 10.1016/j.bmcl.2016.07.020
Acinetobacter baumannii Acinetobacter baumannii MBC 100.0 mg/L 10.1007/s00044-011-9933-5
Acinetobacter baumannii Acinetobacter baumannii MBC nan None 10.1021/acs.jnatprod.2c00065
Acinetobacter baumannii Acinetobacter baumannii MIC 1.0 ug.mL-1 10.1016/j.ejmech.2013.07.041
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/jm00023a011
Acinetobacter baumannii Acinetobacter baumannii MIC 4.0 ug.mL-1 10.1021/np4006025
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Acinetobacter baumannii Acinetobacter baumannii MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Acinetobacter baumannii Acinetobacter baumannii MIC50 nan None 10.1016/j.ejmech.2017.11.094
Acinetobacter baumannii Acinetobacter baumannii MIC>90 0.7 ug ml-1 10.1021/np400145u
Acinetobacter lwoffii Acinetobacter lwoffii Activity 16.0 ug ml-1 10.1128/aac.00652-07
Acinetobacter lwoffii Acinetobacter lwoffii MIC 16.0 ug.mL-1 10.1021/jm00023a011
Aspergillus flavus Aspergillus flavus MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Aspergillus niger Aspergillus niger IC50 31.3 ug.mL-1 10.1021/acs.jnatprod.6b00935
Aspergillus niger Aspergillus niger MIC 31.3 ug.mL-1 10.1021/np500827h
Aspergillus niger Aspergillus niger MIC 50.0 ug.mL-1 10.1016/j.ejmech.2006.11.010
Aspergillus niger Aspergillus niger MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Bacillus anthracis Bacillus anthracis MIC 31.0 ug.mL-1 10.1016/j.ejmech.2019.04.043
Bacillus anthracis Bacillus anthracis MIC 128.0 ug.mL-1 10.1021/acsmedchemlett.5b00255
Bacillus anthracis Bacillus anthracis MIC 5000.0 nM 10.1021/jm9012592
Bacillus cereus Bacillus cereus MBC nan None 10.1021/acs.jnatprod.2c00065
Bacillus cereus Bacillus cereus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Bacillus cereus Bacillus cereus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Bacillus cereus Bacillus cereus MIC 6.25 ug.mL-1 10.1021/np500142g
Bacillus cereus Bacillus cereus MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Bacillus cereus Bacillus cereus MIC 9.4 ug.mL-1 10.1021/acsmedchemlett.5b00255
Bacillus pumilus Bacillus pumilus IZ 0.0 mm 10.1016/j.ejmech.2012.10.038
Bacillus spizizenii Bacillus spizizenii Activity nan None 10.1016/j.bmc.2017.02.068
Bacillus spizizenii Bacillus spizizenii MIC 0.78 ug.mL-1 10.1016/j.ejmech.2013.04.014
Bacillus spizizenii Bacillus spizizenii MIC 0.78 ug.mL-1 10.1021/acs.jnatprod.0c00161
Bacillus spizizenii Bacillus spizizenii Ratio 15.0 None 10.1016/j.bmc.2017.02.068
Bacillus subtilis Bacillus subtilis Activity 1.56 ug ml-1 10.1016/j.ejmech.2010.05.033
Bacillus subtilis Bacillus subtilis FC 2.0 None 10.1016/j.bmc.2016.05.021
Bacillus subtilis Bacillus subtilis IC50 0.37 ug.mL-1 10.1016/j.bmcl.2016.02.043
Bacillus subtilis Bacillus subtilis IC50 1.35 ug.mL-1 10.1016/j.bmcl.2016.02.056
Bacillus subtilis Bacillus subtilis IC50 8.9 ug.mL-1 10.1016/j.bmcl.2014.09.054
Bacillus subtilis Bacillus subtilis IC50 8.9 ug.mL-1 10.1016/j.ejmech.2013.05.004
Bacillus subtilis Bacillus subtilis IC50 8.9 ug.mL-1 10.1016/j.ejmech.2014.02.004
Bacillus subtilis Bacillus subtilis IC50 135.0 nM 10.1016/j.ejmech.2018.04.039
Bacillus subtilis Bacillus subtilis IZ 13.0 mm 10.1016/j.ejmech.2017.11.025
Bacillus subtilis Bacillus subtilis IZ 15.0 mm 10.1016/j.ejmech.2012.01.024
Bacillus subtilis Bacillus subtilis IZ 23.2 mm 10.1016/j.ejmech.2011.03.025
Bacillus subtilis Bacillus subtilis MBC 1.0 ug ml-1 10.1016/j.ejmech.2013.07.041
Bacillus subtilis Bacillus subtilis MBC 4.0 ug ml-1 10.1016/j.bmcl.2006.12.090
Bacillus subtilis Bacillus subtilis MBC 6.25 ug ml-1 10.1016/j.bmcl.2007.05.065
Bacillus subtilis Bacillus subtilis MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.6b00935
Bacillus subtilis Bacillus subtilis MIC 0.1 ug.mL-1 10.1021/np500827h
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2016.02.056
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2013.07.041
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.09.059
Bacillus subtilis Bacillus subtilis MIC 0.39 ug.mL-1 10.1016/j.bmc.2007.03.060
Bacillus subtilis Bacillus subtilis MIC 0.39 ug.mL-1 10.1016/j.bmc.2008.02.006
Bacillus subtilis Bacillus subtilis MIC 0.39 ug.mL-1 10.1016/j.bmc.2008.12.034
Bacillus subtilis Bacillus subtilis MIC 0.39 ug.mL-1 10.1016/j.ejmech.2006.11.010
Bacillus subtilis Bacillus subtilis MIC 0.39 ug.mL-1 10.1016/j.ejmech.2007.11.026
Bacillus subtilis Bacillus subtilis MIC 0.39 ug.mL-1 10.1016/j.ejmech.2010.01.066
Bacillus subtilis Bacillus subtilis MIC 0.4 ug.mL-1 10.1016/j.ejmech.2010.03.027
Bacillus subtilis Bacillus subtilis MIC 0.5 ug.mL-1 10.1021/acs.jnatprod.1c01160
Bacillus subtilis Bacillus subtilis MIC 0.8 ug.mL-1 10.1021/acs.jnatprod.1c01089
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2007.05.013
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2007.09.008
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.1c00922
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1021/jf400718w
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1021/np300554f
Bacillus subtilis Bacillus subtilis MIC 1.35 ug.mL-1 10.1016/j.bmcl.2016.02.043
Bacillus subtilis Bacillus subtilis MIC 1.35 ug.mL-1 10.1016/j.bmcl.2016.03.045
Bacillus subtilis Bacillus subtilis MIC 1.35 ug.mL-1 10.1016/j.bmcl.2016.11.056
Bacillus subtilis Bacillus subtilis MIC 1.5 ug.mL-1 10.1016/j.bmc.2017.02.068
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.bmc.2010.02.052
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.bmc.2011.06.021
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.bmc.2012.05.050
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.bmc.2013.02.008
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.bmc.2013.03.023
Bacillus subtilis Bacillus subtilis MIC 1.56 ug.mL-1 10.1016/j.ejmech.2019.06.068
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.1c00547
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00658
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00801
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.9b01015
Bacillus subtilis Bacillus subtilis MIC 3.0 ug.mL-1 10.1016/j.bmcl.2006.10.094
Bacillus subtilis Bacillus subtilis MIC 3.1 uL/ml 10.1021/jm00200a016
Bacillus subtilis Bacillus subtilis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2006.12.090
Bacillus subtilis Bacillus subtilis MIC 4.0 ug.mL-1 10.1021/acs.jnatprod.8b00685
Bacillus subtilis Bacillus subtilis MIC 5.0 ug.mL-1 10.1016/j.bmcl.2015.10.088
Bacillus subtilis Bacillus subtilis MIC 6.25 ug.mL-1 10.1016/j.bmcl.2007.05.065
Bacillus subtilis Bacillus subtilis MIC 7.81 ug.mL-1 10.1016/j.ejmech.2012.09.004
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.7b00176
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.9b00654
Bacillus subtilis Bacillus subtilis MIC 9.39 ug.mL-1 10.1016/j.ejmech.2021.113202
Bacillus subtilis Bacillus subtilis MIC 9.39 ug.mL-1 10.1021/acs.jmedchem.9b00010
Bacillus subtilis Bacillus subtilis MIC 100.0 nM None
Bacillus subtilis Bacillus subtilis MIC 150.0 ug.mL-1 10.1021/acsmedchemlett.5b00255
Bacillus subtilis Bacillus subtilis MIC 256.0 ug.mL-1 10.1007/s00044-011-9951-3
Bacillus subtilis Bacillus subtilis MIC 1000.0 nM 10.1021/acs.jmedchem.1c00614
Bacillus subtilis Bacillus subtilis MIC 1000.0 nM 10.1021/acs.jmedchem.1c02140
Bacillus subtilis Bacillus subtilis MIC 2000.0 nM 10.1021/acs.jnatprod.2c00967
Bacillus subtilis Bacillus subtilis MIC 2800.0 nM 10.1016/j.ejmech.2018.04.039
Bacillus subtilis Bacillus subtilis MIC 20000.0 nM 10.1016/j.bmcl.2017.01.095
Bacillus subtilis Bacillus subtilis MIC 64000.0 nM 10.1016/j.bmc.2016.05.021
Bacillus subtilis Bacillus subtilis MIC 128000.0 nM 10.1016/j.bmc.2016.05.021
Bacillus subtilis Bacillus subtilis MIC 256000.0 nM 10.1016/j.bmc.2016.05.021
Bacillus subtilis Bacillus subtilis MIC 61920000.0 nM 10.1039/C6MD00278A
Bacillus subtilis Bacillus subtilis MIC50 0.42 ug.mL-1 10.1016/j.ejmech.2011.07.047
Bacillus subtilis Bacillus subtilis MIC50 0.43 ug.mL-1 10.1016/j.bmc.2011.01.051
Bacillus subtilis Bacillus subtilis MIC50 0.48 ug.mL-1 10.1016/j.bmc.2011.05.042
Bacillus subtilis Bacillus subtilis MIC50 1.35 ug.mL-1 10.1016/j.bmcl.2017.01.004
Bacillus subtilis Bacillus subtilis MIC90 0.25 ug.mL-1 10.1016/j.bmcl.2017.01.004
Bacillus subtilis Bacillus subtilis MIC90 1.35 ug.mL-1 10.1016/j.ejmech.2020.113102
Bacillus thuringiensis Bacillus thuringiensis IC50 9.5 ug.mL-1 10.1016/j.bmcl.2014.09.054
Bacillus thuringiensis Bacillus thuringiensis IC50 9.5 ug.mL-1 10.1016/j.ejmech.2013.05.004
Bacillus thuringiensis Bacillus thuringiensis IC50 9.5 ug.mL-1 10.1016/j.ejmech.2014.02.004
Bacillus thuringiensis Bacillus thuringiensis IZ 15.0 mm 10.1016/j.ejmech.2012.10.038
Bacillus thuringiensis Bacillus thuringiensis MIC 4.0 ug.mL-1 10.1021/np300554f
Bacillus thuringiensis Bacillus thuringiensis MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.7b00176
Bacillus thuringiensis Bacillus thuringiensis MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.9b00654
Bifidobacterium bifidum Bifidobacterium bifidum MIC 0.98 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium bifidum Bifidobacterium bifidum MIC 125.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium bifidum Bifidobacterium bifidum MIC 250.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium bifidum Bifidobacterium bifidum MIC 500.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium breve Bifidobacterium breve MIC 500.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium longum Bifidobacterium longum MIC 250.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium longum Bifidobacterium longum MIC 500.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium thermophilum Bifidobacterium thermophilum MIC 500.0 ug.mL-1 10.1128/aac.00261-06
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Burkholderia cepacia Burkholderia cepacia MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Burkholderia pseudomallei Burkholderia pseudomallei MIC 4.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia pseudomallei Burkholderia pseudomallei MIC 64.0 ug.mL-1 10.1128/aac.01803-09
Burkholderia thailandensis Burkholderia thailandensis Inhibition nan % 10.1021/ml400034m
Burkholderia thailandensis Burkholderia thailandensis IZ 6.0 mm 10.1016/j.bmcl.2015.10.096
Burkholderia thailandensis Burkholderia thailandensis IZ 22.0 mm 10.1016/j.bmcl.2015.10.096
Burkholderia thailandensis Burkholderia thailandensis IZ 30.0 mm 10.1016/j.bmcl.2015.10.096
Campylobacter jejuni Campylobacter jejuni MIC 256.0 ug.mL-1 10.1128/aac.01607-07
Candida albicans Candida albicans DIZ nan None 10.1016/j.ejmech.2017.11.025
Candida albicans Candida albicans IC50 62.5 ug.mL-1 10.1021/acs.jnatprod.6b00935
Candida albicans Candida albicans IZ 0.0 mm 10.1021/np900382x
Candida albicans Candida albicans MIC 50.0 ug.mL-1 10.1016/j.ejmech.2006.11.010
Candida albicans Candida albicans MIC 62.5 ug.mL-1 10.1021/np500827h
Candida albicans Candida albicans MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Candida albicans Candida albicans MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Candida albicans Candida albicans MIC 500.0 ug.mL-1 10.1039/C8MD00155C
Candida albicans Candida albicans MIC nan None 10.1021/np500735f
Candida parapsilosis Candida parapsilosis DIZ nan None 10.1016/j.ejmech.2017.11.025
Candida parapsilosis Candida parapsilosis MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Candida parapsilosis Candida parapsilosis MIC nan None 10.1016/j.ejmech.2019.111639
Candida tropicalis Candida tropicalis DIZ nan None 10.1016/j.ejmech.2017.11.025
Candida tropicalis Candida tropicalis MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Candida tropicalis Candida tropicalis MIC nan None 10.1016/j.ejmech.2019.111639
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus sabaeus Vero IC50 100.0 ug.mL-1 10.1021/np400497f
Citrobacter freundii Citrobacter freundii MIC 4.0 ug.mL-1 10.1021/jm00023a011
Citrobacter freundii Citrobacter freundii MIC 128.0 ug.mL-1 10.1128/aac.01395-06
Clavispora lusitaniae Clavispora lusitaniae MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Cryptococcus neoformans Cryptococcus neoformans IC50 7.8 ug.mL-1 10.1021/acs.jnatprod.6b00935
Cryptococcus neoformans Cryptococcus neoformans MIC 125.0 ug.mL-1 10.1039/C8MD00155C
Cryptococcus neoformans Cryptococcus neoformans MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Cryptococcus neoformans Cryptococcus neoformans MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Cryptococcus neoformans Cryptococcus neoformans MIC nan None 10.1016/j.ejmech.2019.111639
Dickeya chrysanthemi Dickeya chrysanthemi IZ 0.0 mm 10.1016/j.ejmech.2012.10.038
Diutina rugosa Diutina rugosa MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Diutina rugosa Diutina rugosa MIC nan None 10.1016/j.ejmech.2019.111639
Electrophorus electricus Acetylcholinesterase Inhibition 17.57 % 10.1016/j.bmc.2012.09.040
Enterobacter cloacae Enterobacter cloacae EC50 37000.0 nM 10.1016/j.bmcl.2016.04.089
Enterobacter cloacae Enterobacter cloacae MBC nan None 10.1021/acs.jnatprod.2c00065
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1021/jm00155a004
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Enterobacter cloacae Enterobacter cloacae MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1021/jm00023a011
Enterobacter cloacae Enterobacter cloacae MIC 32.0 ug.mL-1 10.1021/jm00155a004
Enterobacter cloacae Enterobacter cloacae MIC 125.0 ug.mL-1 10.1021/jm00155a004
Enterobacter cloacae Enterobacter cloacae MIC 128.0 ug.mL-1 10.1021/jm00023a011
Enterobacter cloacae Enterobacter cloacae MIC 256.0 ug.mL-1 10.1128/aac.00726-07
Enterobacter sp. Enterobacter sp. IC50 nan None 10.1016/j.ejmech.2018.04.039
Enterobacter sp. Enterobacter sp. MIC nan None 10.1016/j.ejmech.2018.04.039
Enterococcus Enterococcus MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Enterococcus faecalis Enterococcus faecalis IZ 17.9 mm 10.1016/j.bmcl.2015.04.048
Enterococcus faecalis Enterococcus faecalis MIC 1.56 ug.mL-1 10.1038/nature05756
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1128/aac.00603-06
Enterococcus faecalis Enterococcus faecalis MIC 25.0 ug.mL-1 10.1021/jm500853v
Enterococcus faecalis Enterococcus faecalis MIC 31.0 ug.mL-1 10.1021/jm501082n
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1021/acs.jnatprod.7b00176
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1021/acs.jnatprod.9b00654
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1021/jm00023a011
Enterococcus faecalis Enterococcus faecalis MIC 50.0 uL/ml 10.1021/jm00200a016
Enterococcus faecalis Enterococcus faecalis MIC 250.0 ug.mL-1 10.1016/j.ejmech.2016.12.008
Enterococcus faecalis Enterococcus faecalis MIC 256.0 ug.mL-1 10.1021/acs.jnatprod.7b00565
Enterococcus faecalis Enterococcus faecalis MIC 560.0 ug.mL-1 10.1021/np9805084
Enterococcus faecalis Enterococcus faecalis MIC 1024.0 ug.mL-1 10.1128/aac.00754-08
Enterococcus faecalis Enterococcus faecalis MIC 8000.0 nM 10.1021/acs.jmedchem.1c00614
Enterococcus faecalis Enterococcus faecalis MIC 16000.0 nM 10.1021/acs.jmedchem.1c02140
Enterococcus faecalis Enterococcus faecalis MIC 25000.0 nM None
Enterococcus faecalis Enterococcus faecalis MIC 360000.0 nM 10.1021/np500735f
Enterococcus faecalis Enterococcus faecalis MIC nan None 10.1016/j.bmc.2010.11.001
Enterococcus faecalis Enterococcus faecalis MIC90 nan None 10.1016/j.bmcl.2005.08.032
Enterococcus faecium Enterococcus faecium EC50 100000.0 nM 10.1016/j.bmcl.2016.04.089
Enterococcus faecium Enterococcus faecium IZ 10.0 mm 10.1021/np900382x
Enterococcus faecium Enterococcus faecium MBC 32.0 ug ml-1 10.1021/acs.jnatprod.2c00065
Enterococcus faecium Enterococcus faecium MIC 0.39 ug.mL-1 10.1038/nature05756
Enterococcus faecium Enterococcus faecium MIC 32.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Enterococcus faecium Enterococcus faecium MIC 256.0 ug.mL-1 10.1021/acs.jnatprod.7b00565
Equus caballus Cholinesterase Inhibition -5.91 % 10.1016/j.bmc.2012.09.040
Erwinia Erwinia MIC 3.1 uL/ml 10.1021/jm00200a016
Escherichia coli Escherichia coli Activity 2.9 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 3.13 ug ml-1 10.1016/j.ejmech.2010.05.033
Escherichia coli Escherichia coli Activity 3.3 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 4.9 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 19.3 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmc.2006.11.015
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmc.2018.10.015
Escherichia coli Escherichia coli Activity nan None 10.1016/j.ejmech.2022.114342
Escherichia coli Escherichia coli Activity nan None 10.1039/C2MD20272G
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00014-10
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01677-09
Escherichia coli Escherichia coli Antibiotic resistance nan None 10.1016/s0960-894x(98)00536-8
Escherichia coli Escherichia coli GI 100.0 % 10.1039/c8md00092a
Escherichia coli Escherichia coli IC50 0.13 ug.mL-1 10.1016/j.bmcl.2016.02.043
Escherichia coli Escherichia coli IC50 1.0 ug.mL-1 10.1021/np400473u
Escherichia coli Escherichia coli IC50 1.62 ug.mL-1 10.1016/j.bmcl.2016.02.056
Escherichia coli Escherichia coli IC50 30.0 nM 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli IC50 40.0 nM 10.1021/jm010437x
Escherichia coli Escherichia coli IC50 46.3 ug.mL-1 10.1016/j.bmcl.2014.09.054
Escherichia coli Escherichia coli IC50 47.3 ug.mL-1 10.1016/j.ejmech.2013.05.004
Escherichia coli Escherichia coli IC50 47.3 ug.mL-1 10.1016/j.ejmech.2014.02.004
Escherichia coli Escherichia coli IC50 162.0 nM 10.1016/j.ejmech.2018.04.039
Escherichia coli Escherichia coli IC50 400.0 nM 10.1016/j.bmcl.2006.07.052
Escherichia coli Escherichia coli IC50 400.0 nM 10.1016/j.bmcl.2006.12.024
Escherichia coli Escherichia coli Inhibition nan % 10.1128/aac.00014-10
Escherichia coli Escherichia coli IZ 13.0 mm 10.1016/j.ejmech.2012.01.024
Escherichia coli Escherichia coli IZ 14.0 mm 10.1016/j.ejmech.2017.11.025
Escherichia coli Escherichia coli IZ 15.0 mm 10.1016/j.ejmech.2008.10.006
Escherichia coli Escherichia coli IZ 17.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 18.0 mm 10.1016/j.ejmech.2011.03.025
Escherichia coli Escherichia coli IZ 20.0 mm 10.1016/j.bmcl.2015.02.044
Escherichia coli Escherichia coli IZ 21.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 21.0 mm 10.1021/np900382x
Escherichia coli Escherichia coli IZ 22.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 25.0 mm 10.1007/s00044-009-9214-8
Escherichia coli Escherichia coli IZ 25.0 mm 10.1007/s00044-012-0039-5
Escherichia coli Escherichia coli IZ 37.0 mm 10.1021/np900382x
Escherichia coli Escherichia coli IZ 38.0 mm 10.1021/np100175x
Escherichia coli Escherichia coli IZ nan None 10.1021/np900382x
Escherichia coli Escherichia coli MBC 0.25 ug ml-1 10.1016/j.bmcl.2006.12.090
Escherichia coli Escherichia coli MBC 0.39 ug ml-1 10.1016/j.bmcl.2007.05.065
Escherichia coli Escherichia coli MBC 7.8 ug ml-1 10.1016/j.bmcl.2014.12.029
Escherichia coli Escherichia coli MBC 7.81 ug ml-1 10.1016/j.bmc.2016.05.044
Escherichia coli Escherichia coli MBC 10.0 ug ml-1 10.1128/aac.01087-08
Escherichia coli Escherichia coli MBC 20.0 ug ml-1 10.1128/aac.01087-08
Escherichia coli Escherichia coli MBC 84.4 mg/L 10.1007/s00044-011-9933-5
Escherichia coli Escherichia coli MBC 85.5 mg/L 10.1007/s00044-011-9933-5
Escherichia coli Escherichia coli MBC50 15.6 ug ml-1 10.1016/j.bmcl.2014.12.029
Escherichia coli Escherichia coli MBC90 31.3 ug ml-1 10.1016/j.bmcl.2014.12.029
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.6b00935
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/np500827h
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1021/jm500853v
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1016/j.bmcl.2006.12.090
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1021/np500775e
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00795-06
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01395-06
Escherichia coli Escherichia coli MIC 0.39 ug.mL-1 10.1016/j.bmcl.2007.05.065
Escherichia coli Escherichia coli MIC 0.45 ug.mL-1 10.1016/j.ejmech.2007.05.013
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/jm501082n
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/np4006025
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00454-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00838-06
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 0.512 ug.mL-1 10.1016/j.ejmech.2022.114108
Escherichia coli Escherichia coli MIC 0.6 ug.mL-1 10.1128/aac.01087-08
Escherichia coli Escherichia coli MIC 0.67 ug.mL-1 10.1016/j.bmcl.2016.02.056
Escherichia coli Escherichia coli MIC 0.67 ug.mL-1 10.1016/j.ejmech.2016.09.059
Escherichia coli Escherichia coli MIC 0.78 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 0.8533 ug.mL-1 10.1016/j.ejmech.2022.114108
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.ejmech.2013.07.041
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.1c00922
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jf400718w
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jm501082n
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00339-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01615-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 1.2 ug.mL-1 10.1128/aac.01087-08
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1016/j.ejmech.2013.04.014
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1016/j.ejmech.2019.06.068
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 1.562 ug.mL-1 10.1016/j.bmc.2008.02.006
Escherichia coli Escherichia coli MIC 1.562 ug.mL-1 10.1016/j.bmc.2008.12.034
Escherichia coli Escherichia coli MIC 1.62 ug.mL-1 10.1016/j.bmcl.2016.02.043
Escherichia coli Escherichia coli MIC 1.62 ug.mL-1 10.1016/j.bmcl.2016.03.045
Escherichia coli Escherichia coli MIC 1.62 ug.mL-1 10.1016/j.bmcl.2016.11.056
Escherichia coli Escherichia coli MIC 1.95 ug.mL-1 10.1039/C8MD00155C
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.1c00547
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00801
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/jm00023a011
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/jm00155a004
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/jm00175a009
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/jm501082n
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/np500775e
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01360-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01472-06
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 2.34 ug.mL-1 10.1016/j.ejmech.2021.113202
Escherichia coli Escherichia coli MIC 2.34 ug.mL-1 10.1021/acs.jmedchem.9b00010
Escherichia coli Escherichia coli MIC 2.4 ug.mL-1 10.1128/aac.01087-08
Escherichia coli Escherichia coli MIC 3.0 ug.mL-1 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli MIC 3.1 ug.mL-1 10.1016/j.ejmech.2010.03.027
Escherichia coli Escherichia coli MIC 3.1 uL/ml 10.1021/jm00200a016
Escherichia coli Escherichia coli MIC 3.12 ug.mL-1 10.1038/nature05756
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1016/j.bmc.2010.02.052
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1016/j.bmc.2011.06.021
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1016/j.bmc.2012.05.050
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1016/j.bmc.2013.02.008
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1016/j.bmc.2013.03.023
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1021/jm500853v
Escherichia coli Escherichia coli MIC 3.9 ug.mL-1 10.1016/j.bmc.2007.03.060
Escherichia coli Escherichia coli MIC 3.9 ug.mL-1 10.1016/j.bmcl.2014.12.029
Escherichia coli Escherichia coli MIC 3.9 ug.mL-1 10.1016/j.ejmech.2006.11.010
Escherichia coli Escherichia coli MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.09.008
Escherichia coli Escherichia coli MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.11.026
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.01.027
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2016.12.008
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm00155a004
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01472-06
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 5.0 ug.mL-1 10.1016/j.bmcl.2015.10.088
Escherichia coli Escherichia coli MIC 6.0 ug.mL-1 10.1128/aac.00779-06
Escherichia coli Escherichia coli MIC 6.25 ug.mL-1 10.1016/j.ejmech.2021.113813
Escherichia coli Escherichia coli MIC 6.25 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 7.5 ug.mL-1 10.1021/acs.jnatprod.9b01015
Escherichia coli Escherichia coli MIC 7.8 ug.mL-1 10.1016/j.bmc.2019.05.012
Escherichia coli Escherichia coli MIC 7.8 ug.mL-1 10.1021/np030490j
Escherichia coli Escherichia coli MIC 7.81 ug.mL-1 10.1016/j.bmc.2016.05.044
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.8b00685
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm00023a011
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm400097h
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00167-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00580-10
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00780-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01048-06
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.01677-09
Escherichia coli Escherichia coli MIC 9.39 ug.mL-1 10.1016/j.ejmech.2021.113202
Escherichia coli Escherichia coli MIC 9.39 ug.mL-1 10.1021/acs.jmedchem.9b00010
Escherichia coli Escherichia coli MIC 12.0 ug.mL-1 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1016/j.bmcl.2009.09.095
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1016/j.bmcl.2010.12.084
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 14.0 ug.mL-1 10.1021/acs.jmedchem.7b00204
Escherichia coli Escherichia coli MIC 15.63 ug.mL-1 10.1128/aac.00580-10
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1007/s00044-011-9951-3
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2005.04.066
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2011.08.095
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.ejmech.2009.03.006
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.2c00658
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/np300554f
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/np500775e
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00838-06
Escherichia coli Escherichia coli MIC 25.0 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 28.0 ug.mL-1 10.1021/np9805084
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/jm00155a004
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/np300554f
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00167-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00710-10
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00780-06
Escherichia coli Escherichia coli MIC 48.0 ug.mL-1 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1016/j.ejmech.2018.11.016
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1021/acs.jnatprod.0c00161
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC 63.0 ug.mL-1 10.1021/jm00155a004
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1039/d2md00041e
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01360-08
Escherichia coli Escherichia coli MIC 96.0 ug.mL-1 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli MIC 100.0 uL/ml 10.1021/jm00200a016
Escherichia coli Escherichia coli MIC 125.0 ug.mL-1 10.1021/jm00155a004
Escherichia coli Escherichia coli MIC 125.0 ug.mL-1 10.1021/jm00175a009
Escherichia coli Escherichia coli MIC 125.0 ug.mL-1 10.1128/aac.00580-10
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1021/jm00023a011
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00339-07
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.00780-06
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01360-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01395-06
Escherichia coli Escherichia coli MIC 250.0 ug.mL-1 10.1128/aac.00779-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1039/d2md00459c
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00726-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00795-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.01615-09
Escherichia coli Escherichia coli MIC 384.0 ug.mL-1 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli MIC 400.0 nM None
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00143-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01048-06
Escherichia coli Escherichia coli MIC 1024.0 ug.mL-1 10.1128/aac.01126-09
Escherichia coli Escherichia coli MIC 1260.0 nM 10.1016/j.ejmech.2015.08.025
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jnatprod.2c00967
Escherichia coli Escherichia coli MIC 3300.0 nM 10.1016/j.ejmech.2018.04.039
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1039/c8md00092a
Escherichia coli Escherichia coli MIC 4350.0 nM 10.1016/j.ejmech.2015.08.025
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli MIC 10000.0 nM 10.1021/acsmedchemlett.5b00024
Escherichia coli Escherichia coli MIC 10000.0 nM 10.1021/jm9012592
Escherichia coli Escherichia coli MIC 12500.0 nM 10.1016/j.bmcl.2017.05.060
Escherichia coli Escherichia coli MIC 128000.0 nM 10.1021/np500735f
Escherichia coli Escherichia coli MIC 1024000.0 nM 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli MIC 3340000.0 nM 10.1039/C6MD00278A
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00719-10
Escherichia coli Escherichia coli MIC50 1.62 ug.mL-1 10.1016/j.bmcl.2017.01.004
Escherichia coli Escherichia coli MIC50 3.5 ug.mL-1 10.1016/j.bmc.2013.06.066
Escherichia coli Escherichia coli MIC50 7.8 ug.mL-1 10.1016/j.bmcl.2014.12.029
Escherichia coli Escherichia coli MIC50 33.02 mmol/ml 10.1016/j.ejmech.2010.02.023
Escherichia coli Escherichia coli MIC90 0.67 ug.mL-1 10.1016/j.bmcl.2017.01.004
Escherichia coli Escherichia coli MIC90 1.62 ug.mL-1 10.1016/j.ejmech.2020.113102
Escherichia coli Escherichia coli MIC90 15.6 ug.mL-1 10.1016/j.bmcl.2014.12.029
Escherichia coli Escherichia coli MIC90 15.6 ug.mL-1 10.1016/j.ejmech.2017.11.094
Escherichia coli Escherichia coli MIC90 16.0 ug.mL-1 10.1016/j.bmcl.2005.08.032
Escherichia coli Escherichia coli MIC99 8.0 ug ml-1 10.1021/acs.jmedchem.5b01912
Escherichia coli Escherichia coli Ratio 0.87 None 10.1128/aac.00779-06
Escherichia coli Escherichia coli Ratio 1.0 None 10.1128/aac.00339-07
Escherichia coli Escherichia coli Ratio 15.0 None 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli Ratio 32.0 None 10.1016/j.bmc.2017.02.068
Escherichia coli Escherichia coli Ratio 128.0 None 10.1016/j.bmc.2017.02.068
Escherichia coli K-12 3-oxoacyl-[acyl-carrier-protein] synthase 3 IC50 6800.0 nM 10.1016/j.bmcl.2014.09.054
Fusarium graminearum Fusarium graminearum MIC 125.0 ug.mL-1 10.1039/C8MD00155C
Fusarium graminearum Fusarium graminearum MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Fusarium oxysporum Fusarium oxysporum MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Haemophilus influenzae Haemophilus influenzae MIC 9.4 ug.mL-1 10.1021/acsmedchemlett.5b00255
Homo sapiens 5637 Activity nan None 10.1128/aac.00014-10
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bradykinin B2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 FC 1.0 None 10.1016/j.bmcl.2016.06.088
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Gap junction alpha-1 protein IC50 48000.0 nM 10.1016/j.ejmech.2020.112602
Homo sapiens Gap junction beta-2 protein IC50 9400.0 nM 10.1021/acsmedchemlett.8b00158
Homo sapiens Gap junction beta-2 protein IC50 11500.0 nM 10.1016/j.ejmech.2020.112602
Homo sapiens Ghrelin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 Inhibition nan % 10.1039/c8md00092a
Homo sapiens Melanocortin receptor 3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens microRNA 21 IC50 1102.0 nM 10.1039/c8md00092a
Homo sapiens microRNA 21 Inhibition 100.0 % 10.1039/c8md00092a
Homo sapiens microRNA 21 Inhibition nan % 10.1021/acsmedchemlett.9b00091
Homo sapiens microRNA 21 Kd 100.0 nM 10.1021/acsmedchemlett.9b00091
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Thromboxane A2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Type-1 angiotensin II receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Klebsiella Klebsiella MIC nan None 10.1021/jm00200a016
Klebsiella aerogenes Klebsiella aerogenes MBC 0.25 ug ml-1 10.1016/j.bmcl.2006.12.090
Klebsiella aerogenes Klebsiella aerogenes MIC 0.25 ug.mL-1 10.1016/j.bmcl.2006.12.090
Klebsiella aerogenes Klebsiella aerogenes MIC 1.0 ug.mL-1 10.1128/aac.00710-10
Klebsiella aerogenes Klebsiella aerogenes MIC 3.9 ug.mL-1 10.1016/j.bmcl.2016.02.024
Klebsiella aerogenes Klebsiella aerogenes MIC 16.0 ug.mL-1 10.1128/aac.00710-10
Klebsiella oxytoca Klebsiella oxytoca DIZ nan None 10.1016/j.ejmech.2017.11.025
Klebsiella oxytoca Klebsiella oxytoca MBC nan None 10.1021/acs.jnatprod.2c00065
Klebsiella oxytoca Klebsiella oxytoca MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1128/aac.00710-10
Klebsiella pneumoniae Klebsiella pneumoniae IZ 15.0 mm 10.1016/j.ejmech.2012.10.038
Klebsiella pneumoniae Klebsiella pneumoniae IZ 18.0 mm 10.1016/j.ejmech.2012.01.024
Klebsiella pneumoniae Klebsiella pneumoniae IZ 19.5 mm 10.1016/j.ejmech.2011.03.025
Klebsiella pneumoniae Klebsiella pneumoniae MBC 12.5 mg/L 10.1007/s00044-011-9933-5
Klebsiella pneumoniae Klebsiella pneumoniae MBC 16.0 mg/L 10.1007/s00044-011-9933-5
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1016/j.bmc.2010.11.001
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1021/jm00155a004
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2016.12.008
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm00023a011
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2016.02.024
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1016/j.bmcl.2005.04.066
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2009.03.006
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00167-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2011.08.095
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1021/jm00023a011
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.00726-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 200.0 ug.mL-1 10.1021/jm500853v
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6250.0 nM 10.1016/j.bmcl.2017.05.060
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32000.0 nM 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64000.0 nM 10.1021/acs.jmedchem.1c02140
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 66.05 mmol/ml 10.1016/j.ejmech.2010.02.023
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 nan None 10.1016/j.ejmech.2017.11.094
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 32.0 ug.mL-1 10.1016/j.bmcl.2005.08.032
Klebsiella pneumoniae subsp. pneumoniae Klebsiella pneumoniae subsp. pneumoniae EC50 45000.0 nM 10.1016/j.bmcl.2016.04.089
Kluyveromyces marxianus Kluyveromyces marxianus MIC 250.0 ug.mL-1 10.1039/C8MD00155C
Legionella pneumophila Legionella pneumophila MIC 12.5 ug.mL-1 10.1021/np100730b
Listeria monocytogenes Listeria monocytogenes IZ 15.0 mm 10.1007/s00044-009-9214-8
Listeria monocytogenes Listeria monocytogenes IZ 15.0 mm 10.1007/s00044-012-0039-5
Listeria monocytogenes Listeria monocytogenes MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Listeria monocytogenes Listeria monocytogenes MIC 4.7 ug.mL-1 10.1021/acsmedchemlett.5b00255
Listeria monocytogenes Listeria monocytogenes MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Microbotryum violaceum Microbotryum violaceum IZ nan None 10.1021/np100730b
Micrococcus luteus Micrococcus luteus Activity nan None 10.1016/j.bmc.2018.10.015
Micrococcus luteus Micrococcus luteus IZ 16.0 mm 10.1016/j.bmcl.2015.04.048
Micrococcus luteus Micrococcus luteus MBC 0.25 ug ml-1 10.1016/j.bmcl.2006.12.090
Micrococcus luteus Micrococcus luteus MBC 0.39 ug ml-1 10.1016/j.bmcl.2007.05.065
Micrococcus luteus Micrococcus luteus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2006.12.090
Micrococcus luteus Micrococcus luteus MIC 0.39 ug.mL-1 10.1016/j.bmcl.2007.05.065
Micrococcus luteus Micrococcus luteus MIC 0.5 ug.mL-1 10.1021/np4006025
Micrococcus luteus Micrococcus luteus MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.6b00935
Micrococcus luteus Micrococcus luteus MIC 1.0 ug.mL-1 10.1021/np500827h
Micrococcus luteus Micrococcus luteus MIC 1.95 ug.mL-1 10.1039/C8MD00155C
Micrococcus luteus Micrococcus luteus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Micrococcus luteus Micrococcus luteus MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Micrococcus luteus Micrococcus luteus MIC 15.0 ug.mL-1 10.1021/acs.jnatprod.9b01015
Micrococcus luteus Micrococcus luteus MIC 32.0 ug.mL-1 10.1021/np300554f
Micrococcus luteus Micrococcus luteus MIC 12800.0 nM 10.1016/j.bmcl.2023.129323
Micrococcus luteus Micrococcus luteus MIC 20000.0 nM 10.1021/jm9012592
Mus musculus Mus musculus LD50 280.0 mg.kg-1 10.1016/j.bmc.2017.02.068
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mycobacterium avium Mycobacterium avium MIC 1.56 ug.mL-1 10.1016/j.bmcl.2009.09.095
Mycobacterium avium Mycobacterium avium MIC 3.13 ug.mL-1 10.1016/j.bmcl.2010.12.084
Mycobacterium avium Mycobacterium avium MIC 100.0 ug.mL-1 10.1016/j.bmcl.2009.09.095
Mycobacterium intracellulare Mycobacterium intracellulare MIC 6.25 ug.mL-1 10.1021/jm00150a006
Mycobacterium kansasii Mycobacterium kansasii MIC 25.0 ug.mL-1 10.1021/jm00150a006
Mycobacterium leprae Mycobacterium leprae Activity 99.7 % 10.1016/j.bmc.2019.04.032
Mycobacterium leprae Mycobacterium leprae Activity 99.8 % 10.1016/j.bmc.2019.04.032
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity nan None 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis GI nan None 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis IC50 2.5 ug.mL-1 10.1021/np9000703
Mycobacterium tuberculosis Mycobacterium tuberculosis Inhibition 90.0 % 10.1016/j.bmcl.2004.05.060
Mycobacterium tuberculosis Mycobacterium tuberculosis Inhibition nan % 10.1021/acs.jmedchem.5b00608
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.2 ug.mL-1 10.1016/j.bmcl.2005.06.010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 0.6 ug.mL-1 10.1016/j.ejmech.2016.02.008
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2017.06.005
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.56 ug.mL-1 10.1016/j.bmcl.2009.09.095
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.56 ug.mL-1 10.1016/j.bmcl.2010.12.084
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.0 ug.mL-1 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.5 ug.mL-1 10.1016/j.ejmech.2010.07.003
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.5 ug.mL-1 10.1021/np070174v
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.5 ug.mL-1 10.1021/np900342b
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 2.5 ug.mL-1 10.1039/C9MD00057G
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3.13 ug.mL-1 10.1021/jm00150a006
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 5.0 ug.mL-1 10.1016/j.ejmech.2009.07.015
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 5.0 ug.mL-1 10.1016/j.ejmech.2018.11.032
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 5.0 ug.mL-1 10.1021/np9700681
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 6.25 ug.mL-1 10.1021/jm00150a006
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2019.01.002
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.01.002
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 16.0 ug.mL-1 10.1128/aac.00661-10
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 32.0 ug.mL-1 10.1016/j.ejmech.2019.01.002
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 100.0 ug.mL-1 10.1021/jm00150a006
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 3500.0 nM 10.1021/np0498354
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1021/jm500853v
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 1.219 ug.mL-1 10.1016/j.bmcl.2022.128824
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 1.219 ug.mL-1 10.1016/j.bmcl.2022.128871
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 1.235 ug.mL-1 10.1016/j.bmcl.2022.128824
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 1.235 ug.mL-1 10.1016/j.bmcl.2022.128871
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=<90 2.0 ug ml-1 10.1016/j.ejmech.2021.113202
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC=<90 128.0 ug ml-1 10.1016/j.ejmech.2021.113202
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 0.65 ug.mL-1 10.1021/np400497f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 0.72 ug.mL-1 10.1021/np400497f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 0.73 ug.mL-1 10.1021/np400497f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 0.76 ug.mL-1 10.1021/np400497f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 1.12 ug.mL-1 10.1021/np400497f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 1.907 ug.mL-1 10.1016/j.bmcl.2022.128824
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 1.907 ug.mL-1 10.1016/j.bmcl.2022.128871
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 25.0 ug.mL-1 10.1021/np400497f
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 40.0 ug.mL-1 10.1016/j.bmcl.2022.128824
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 40.0 ug.mL-1 10.1016/j.bmcl.2022.128871
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 3125.0 nM 10.1016/j.ejmech.2012.08.047
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 3400.0 nM 10.1016/j.ejmech.2016.07.039
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC90 16100.0 nM 10.1039/d2md00155a
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC>99 6.45 uM 10.1016/j.bmc.2015.10.021
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 0.32 uM 10.1021/acs.jmedchem.7b01347
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 5.4 uM 10.1021/ml300362a
Mycobacterium tuberculosis Mycobacterium tuberculosis Ratio 1.0 None 10.1016/j.ejmech.2016.02.008
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Polyketide synthase Pks13 MIC=<90 2.0 ug ml-1 10.1021/acs.jmedchem.9b00010
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Polyketide synthase Pks13 MIC=<90 128.0 ug ml-1 10.1021/acs.jmedchem.9b00010
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 1.0 ug.mL-1 10.1128/aac.01302-08
Mycobacterium ulcerans Mycobacterium ulcerans Activity nan None 10.1128/aac.01260-10
Mycobacterium ulcerans Mycobacterium ulcerans MIC 5.0 ug.mL-1 10.1128/aac.00400-10
Mycobacterium ulcerans Mycobacterium ulcerans TIME 504.0 hr 10.1128/aac.01260-10
Mycobacteroides abscessus Mycobacteroides abscessus MIC 4.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides abscessus Mycobacteroides abscessus MIC 8.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides abscessus Mycobacteroides abscessus MIC 16.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides abscessus Mycobacteroides abscessus MIC 128.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides abscessus Mycobacteroides abscessus MIC50 8.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides abscessus Mycobacteroides abscessus MIC90 8.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides chelonae Mycobacteroides chelonae MIC 10.0 ug.mL-1 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC 50.0 ug.mL-1 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC nan None 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC50 4.0 ug.mL-1 10.1128/aac.01551-06
Mycobacteroides chelonae Mycobacteroides chelonae MIC90 8.0 ug.mL-1 10.1128/aac.01551-06
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC 32.0 ug.mL-1 10.1128/aac.01551-06
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC 128.0 ug.mL-1 10.1128/aac.01551-06
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 8.0 ug.mL-1 10.1128/aac.01551-06
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC90 32.0 ug.mL-1 10.1128/aac.01551-06
Mycolicibacterium phlei Mycolicibacterium phlei MBC 1.0 ug ml-1 10.1021/acs.jnatprod.2c00065
Mycolicibacterium phlei Mycolicibacterium phlei MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Activity nan None 10.1016/j.ejmech.2019.05.081
Mycolicibacterium smegmatis Mycolicibacterium smegmatis FC 2.0 None 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis FICI 0.5 None 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis FICI 1.0 None 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 1.0 ug.mL-1 10.1021/np400473u
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IZ 40.0 mm 10.1016/j.ejmech.2008.10.006
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MBC 0.5 ug ml-1 10.1021/acs.jnatprod.2c00065
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.2 ug.mL-1 10.1021/np900572g
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.5b01375
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.1c01160
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.4 ug.mL-1 10.1021/acs.jnatprod.7b00713
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.4 ug.mL-1 10.1021/acs.jnatprod.8b01086
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.5 ug.mL-1 10.1021/acs.jnatprod.2c00065
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.5 ug.mL-1 10.1128/aac.00735-10
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.6 ug.mL-1 10.1021/acs.jnatprod.0c00486
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1.7 ug.mL-1 10.1021/acs.jnatprod.1c00975
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 3.13 ug.mL-1 10.1016/j.bmcl.2009.09.095
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 4.1 ug.mL-1 10.1021/acs.jnatprod.9b00604
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 10.0 ug.mL-1 10.1021/acs.jnatprod.6b00786
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 128.0 ug.mL-1 10.1021/acsmedchemlett.5b00255
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1600.0 nM 10.1016/j.bmcl.2023.129323
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC50 0.4 ug.mL-1 10.1016/j.bmcl.2022.128692
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC50 0.48 ug.mL-1 10.1016/j.bmcl.2022.128692
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC50 0.49 ug.mL-1 10.1016/j.bmcl.2022.128692
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC90 0.87 ug.mL-1 10.1016/j.bmcl.2022.128692
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC90 0.94 ug.mL-1 10.1016/j.bmcl.2022.128692
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC90 1.07 ug.mL-1 10.1016/j.bmcl.2022.128692
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC99 0.89 uM 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC99 1.76 uM 10.1039/C3MD00387F
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC99 3.57 uM 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC99 7.16 uM 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Ratio 0.249 None 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Ratio 0.497 None 10.1016/j.bmc.2014.06.012
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Ratio 0.5 None 10.1016/j.bmc.2014.06.012
Nakaseomyces glabratus Nakaseomyces glabratus MIC nan None 10.1021/np500735f
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 2.0 ug.mL-1 10.1128/aac.00583-09
Nocardia farcinica Nocardia farcinica MIC 256.0 ug.mL-1 10.1128/aac.00021-10
Nocardia farcinica Nocardia farcinica MIC 1024.0 ug.mL-1 10.1128/aac.00021-10
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Plasmodium falciparum MIC 2.5 ug.mL-1 10.1021/np0602012
Proteus Proteus IZ 25.0 mm 10.1007/s00044-009-9214-8
Proteus mirabilis Proteus mirabilis IZ 20.0 mm 10.1016/j.bmcl.2015.02.044
Proteus mirabilis Proteus mirabilis MIC 2.0 ug.mL-1 10.1021/jm00155a004
Proteus vulgaris Proteus vulgaris MBC 0.5 ug ml-1 10.1016/j.bmcl.2006.12.090
Proteus vulgaris Proteus vulgaris MIC 0.25 ug.mL-1 10.1016/j.bmcl.2006.12.090
Proteus vulgaris Proteus vulgaris MIC 3.1 uL/ml 10.1021/jm00200a016
Proteus vulgaris Proteus vulgaris MIC 5.0 ug.mL-1 10.1016/j.bmcl.2015.10.088
Providencia rettgeri Providencia rettgeri MIC 0.25 ug.mL-1 10.1021/jm00175a009
Providencia rettgeri Providencia rettgeri MIC 0.5 ug.mL-1 10.1021/jm00155a004
Providencia rettgeri Providencia rettgeri MIC 2.0 ug.mL-1 10.1021/jm00155a004
Providencia rettgeri Providencia rettgeri MIC 125.0 ug.mL-1 10.1021/jm00175a009
Providencia stuartii Providencia stuartii MIC 0.5 ug.mL-1 10.1021/jm00155a004
Providencia stuartii Providencia stuartii MIC 4.0 ug.mL-1 10.1021/jm00155a004
Pseudomonas Pseudomonas IC50 0.49 ug.mL-1 10.1016/j.bmcl.2016.02.056
Pseudomonas Pseudomonas MIC 0.012 ug.mL-1 10.1016/j.bmcl.2016.02.056
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.bmc.2018.10.015
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/acs.jmedchem.5b01912
Pseudomonas aeruginosa Pseudomonas aeruginosa DIZ nan None 10.1016/j.ejmech.2017.11.025
Pseudomonas aeruginosa Pseudomonas aeruginosa EC50 25000.0 nM 10.1016/j.bmcl.2016.04.089
Pseudomonas aeruginosa Pseudomonas aeruginosa GI 11.0 % 10.1039/c8md00092a
Pseudomonas aeruginosa Pseudomonas aeruginosa GI 100.0 % 10.1021/acs.jnatprod.9b00416
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 6.8 ug.mL-1 10.1016/j.bmcl.2014.09.054
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 6.8 ug.mL-1 10.1016/j.ejmech.2013.05.004
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 6.8 ug.mL-1 10.1016/j.ejmech.2014.02.004
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 49.0 nM 10.1016/j.ejmech.2018.04.039
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 209.0 ug.mL-1 10.1021/np400473u
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 0.0 mm 10.1016/j.bmcl.2015.10.096
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 0.0 mm 10.1016/j.ejmech.2012.10.038
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 20.0 mm 10.1016/j.ejmech.2008.10.006
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 21.0 mm 10.1016/j.ejmech.2012.01.024
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 32.0 ug ml-1 10.1021/acs.jnatprod.2c00065
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 47.9 mg/L 10.1007/s00044-011-9933-5
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 48.4 mg/L 10.1007/s00044-011-9933-5
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 128.0 ug ml-1 10.1016/j.bmcl.2006.12.090
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.49 ug.mL-1 10.1016/j.bmcl.2016.11.056
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1016/j.ejmech.2019.06.068
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1007/s00044-011-9951-3
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.1 ug.mL-1 10.1016/j.ejmech.2010.03.027
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.12.034
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.13 ug.mL-1 10.1016/j.bmc.2010.02.052
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.13 ug.mL-1 10.1016/j.bmc.2011.06.021
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.13 ug.mL-1 10.1016/j.bmc.2012.05.050
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.13 ug.mL-1 10.1016/j.bmc.2013.02.008
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.13 ug.mL-1 10.1016/j.bmc.2013.03.023
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/jm00175a009
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.07.041
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 25.0 ug.mL-1 10.1038/nature05756
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2011.08.095
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00793
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/jm00155a004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 37.5 ug.mL-1 10.1021/acsmedchemlett.5b00255
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50.0 uL/ml 10.1021/jm00200a016
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 63.0 ug.mL-1 10.1021/jm00155a004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2006.12.090
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/jm501082n
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1039/d2md00041e
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00704-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.00710-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 100.0 uL/ml 10.1021/jm00200a016
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 125.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 125.0 ug.mL-1 10.1016/j.ejmech.2016.12.008
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 125.0 ug.mL-1 10.1021/jm00155a004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 125.0 ug.mL-1 10.1021/jm00175a009
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1016/j.bmcl.2005.04.066
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/jm00023a011
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/jm501082n
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.00704-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 140.0 ug.mL-1 10.1021/np9805084
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 200.0 ug.mL-1 10.1021/jm500853v
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 250.0 ug.mL-1 10.1016/j.ejmech.2012.09.004
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.00704-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.00710-10
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1128/aac.00704-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1010.0 nM 10.1016/j.ejmech.2018.04.039
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1024.0 ug.mL-1 10.1128/aac.00704-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 7160.0 nM 10.1016/j.ejmech.2015.08.025
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8000.0 nM 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128000.0 nM 10.1021/acs.jmedchem.1c02140
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 200000.0 nM 10.1021/jm9012592
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256000.0 nM 10.1039/c8md00092a
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1010000.0 nM 10.1039/C6MD00278A
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.00704-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 1500.0 ug.mL-1 10.1016/j.ejmech.2017.11.094
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 0.49 ug.mL-1 10.1016/j.ejmech.2020.113102
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 128.0 ug.mL-1 10.1016/j.bmcl.2005.08.032
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC99 32.0 ug ml-1 10.1021/acs.jmedchem.5b01912
Pseudomonas fluorescens Pseudomonas fluorescens Activity 3.13 ug ml-1 10.1016/j.ejmech.2010.05.033
Pseudomonas fluorescens Pseudomonas fluorescens IC50 0.014 ug.mL-1 10.1016/j.bmcl.2016.02.043
Pseudomonas fluorescens Pseudomonas fluorescens MIC 0.012 ug.mL-1 10.1016/j.ejmech.2016.09.059
Pseudomonas fluorescens Pseudomonas fluorescens MIC 0.49 ug.mL-1 10.1016/j.bmcl.2016.02.043
Pseudomonas fluorescens Pseudomonas fluorescens MIC 0.49 ug.mL-1 10.1016/j.bmcl.2016.03.045
Pseudomonas fluorescens Pseudomonas fluorescens MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.02.006
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.13 ug.mL-1 10.1016/j.ejmech.2013.04.014
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.9 ug.mL-1 10.1016/j.bmc.2007.03.060
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.9 ug.mL-1 10.1016/j.ejmech.2006.11.010
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.05.013
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.09.008
Pseudomonas fluorescens Pseudomonas fluorescens MIC 3.9 ug.mL-1 10.1016/j.ejmech.2007.11.026
Pseudomonas fluorescens Pseudomonas fluorescens MIC 5.08 ug.mL-1 10.1016/j.ejmech.2010.01.066
Pseudomonas fluorescens Pseudomonas fluorescens MIC50 0.49 ug.mL-1 10.1016/j.bmcl.2017.01.004
Pseudomonas fluorescens Pseudomonas fluorescens MIC90 0.012 ug.mL-1 10.1016/j.bmcl.2017.01.004
Pseudomonas putida Pseudomonas putida Activity nan None 10.1128/aac.00583-09
Pseudomonas putida Pseudomonas putida IZ 14.0 mm 10.1007/s00044-009-9214-8
Pseudomonas syringae Pseudomonas syringae MIC 10.0 ug.mL-1 10.1016/j.bmcl.2015.10.088
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Lysosomal phospholipase A1 IC50 110000.0 nM 10.1021/jm00108a036
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Phosphatidylserine-specific phospholipase A1 IC50 39.0 ug.mL-1 10.1021/jm00023a011
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 44000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 348.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 349.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 359.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 393.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 51.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 59.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 61.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 89.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 140.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 183.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 196.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 760.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 780.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 846.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 853.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 155.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 213.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 227.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 333.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 46.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 48.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 49.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1486.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1516.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1590.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1610.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.4 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.23 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 138300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 80.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 84.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 91.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 111.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11166.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13316.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13345.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13692.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.93 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.43 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.63 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 367300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 372300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 383700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.23 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.3 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 45.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 62.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 198.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 403.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 972.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1370.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1443.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2039.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 115.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 115.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 142.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1118330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1183670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1258000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1277000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.39 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.91 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 65700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5200000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5360000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5610000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5780000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.53 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 147.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 20.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12230.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15030.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15470.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rhodotorula mucilaginosa Rhodotorula mucilaginosa MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 1.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 3.0 mm 10.1016/j.ejmech.2010.07.050
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC nan None 10.1021/np500735f
Salmonella Salmonella MIC 3.1 uL/ml 10.1021/jm00200a016
Salmonella enterica Salmonella enterica MIC 14.0 ug.mL-1 10.1021/acs.jnatprod.9b01015
Salmonella enterica Salmonella enterica MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis Activity nan None 10.1021/acs.jmedchem.9b00720
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi IZ 20.0 mm 10.1007/s00044-012-0039-5
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1128/aac.00382-07
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium EC50 3.5 ug.mL-1 10.1128/aac.00382-07
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium EC50 29.0 ug.mL-1 10.1128/aac.00382-07
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium IZ 14.0 mm 10.1016/j.ejmech.2012.01.024
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium IZ 20.0 mm 10.1007/s00044-009-9214-8
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 1.5 ug.mL-1 10.1128/aac.00205-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 4.0 ug.mL-1 10.1128/aac.01472-06
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 8.0 ug.mL-1 10.1128/aac.00382-07
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 8.0 ug.mL-1 10.1128/aac.00600-06
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 15.62 ug.mL-1 10.1016/j.ejmech.2012.09.004
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 64.0 ug.mL-1 10.1128/aac.00600-06
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 250.0 ug.mL-1 10.1128/aac.00382-07
Serratia Serratia MIC 3.1 uL/ml 10.1021/jm00200a016
Serratia Serratia MIC 100.0 uL/ml 10.1021/jm00200a016
Serratia marcescens Serratia marcescens IZ 45.0 mm 10.1016/j.ejmech.2008.10.006
Serratia marcescens Serratia marcescens MIC 1.0 ug.mL-1 10.1021/jm00155a004
Serratia marcescens Serratia marcescens MIC 1.56 ug.mL-1 10.1128/aac.00631-09
Serratia marcescens Serratia marcescens MIC 8.0 ug.mL-1 10.1021/jm00023a011
Serratia marcescens Serratia marcescens MIC 64.0 ug.mL-1 10.1021/jm00023a011
Serratia marcescens Serratia marcescens MIC 128.0 ug.mL-1 10.1021/jm00023a011
Serratia marcescens Serratia marcescens MIC 400.0 ug.mL-1 10.1128/aac.00631-09
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Shigella boydii Shigella boydii IZ 14.0 mm 10.1007/s00044-009-9214-8
Shigella boydii Shigella boydii IZ 15.0 mm 10.1007/s00044-009-9214-8
Shigella boydii Shigella boydii IZ 16.0 mm 10.1007/s00044-009-9214-8
Shigella dysenteriae Shigella dysenteriae MIC 0.2 ug.mL-1 10.1021/acs.jnatprod.9b01071
Shigella flexneri Shigella flexneri Activity 16.0 ug ml-1 10.1128/aac.00652-07
Staphylococcus aureus Staphylococcus aureus Activity 1.56 ug ml-1 10.1016/j.ejmech.2010.05.033
Staphylococcus aureus Staphylococcus aureus Activity 30.0 None 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus Activity 200.0 None 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus Activity 1000.0 None 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2018.11.012
Staphylococcus aureus Staphylococcus aureus Antibiotic resistance nan None 10.1016/s0960-894x(98)00536-8
Staphylococcus aureus Staphylococcus aureus EC50 8200.0 nM 10.1016/j.bmcl.2016.04.089
Staphylococcus aureus Staphylococcus aureus EC50 100000.0 nM 10.1016/j.bmcl.2016.04.089
Staphylococcus aureus Staphylococcus aureus FC 3.0 None 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus GI 41.0 % 10.1039/c8md00092a
Staphylococcus aureus Staphylococcus aureus GI 100.0 % 10.1021/acs.jnatprod.9b00416
Staphylococcus aureus Staphylococcus aureus GI 100.0 % 10.1039/c8md00092a
Staphylococcus aureus Staphylococcus aureus GI nan None 10.1016/j.bmc.2015.04.069
Staphylococcus aureus Staphylococcus aureus IC50 30.0 ug.mL-1 10.1016/j.bmcl.2016.02.043
Staphylococcus aureus Staphylococcus aureus IC50 30.0 ug.mL-1 10.1016/j.bmcl.2016.02.056
Staphylococcus aureus Staphylococcus aureus IC50 300.0 nM 10.1016/j.ejmech.2018.04.039
Staphylococcus aureus Staphylococcus aureus IZ 0.0 mm 10.1021/np900382x
Staphylococcus aureus Staphylococcus aureus IZ 9.0 mm 10.1016/j.ejmech.2012.01.024
Staphylococcus aureus Staphylococcus aureus IZ 10.0 mm 10.1016/j.ejmech.2012.10.038
Staphylococcus aureus Staphylococcus aureus IZ 12.01 mm 10.1016/j.ejmech.2018.11.012
Staphylococcus aureus Staphylococcus aureus IZ 15.0 mm 10.1021/np900382x
Staphylococcus aureus Staphylococcus aureus IZ 16.3 mm 10.1016/j.bmcl.2015.04.048
Staphylococcus aureus Staphylococcus aureus IZ 17.0 mm 10.1016/j.ejmech.2017.11.025
Staphylococcus aureus Staphylococcus aureus IZ 23.0 mm 10.1021/acs.jnatprod.6b01046
Staphylococcus aureus Staphylococcus aureus IZ 25.0 mm 10.1007/s00044-009-9214-8
Staphylococcus aureus Staphylococcus aureus IZ 25.0 mm 10.1007/s00044-012-0039-5
Staphylococcus aureus Staphylococcus aureus IZ 25.1 mm 10.1016/j.ejmech.2011.03.025
Staphylococcus aureus Staphylococcus aureus IZ 28.0 mm 10.1016/j.bmcl.2007.05.065
Staphylococcus aureus Staphylococcus aureus IZ 37.0 mm 10.1021/np100175x
Staphylococcus aureus Staphylococcus aureus MBC 0.5 ug ml-1 10.1016/j.bmcl.2006.12.090
Staphylococcus aureus Staphylococcus aureus MBC 0.78 ug ml-1 10.1016/j.bmcl.2007.05.065
Staphylococcus aureus Staphylococcus aureus MBC 1.95 ug ml-1 10.1016/j.bmc.2016.05.044
Staphylococcus aureus Staphylococcus aureus MBC 4.0 ug ml-1 10.1016/j.ejmech.2013.07.041
Staphylococcus aureus Staphylococcus aureus MBC 11.7 ug ml-1 10.1016/j.bmcl.2014.12.029
Staphylococcus aureus Staphylococcus aureus MBC 17.9 mg/L 10.1007/s00044-011-9933-5
Staphylococcus aureus Staphylococcus aureus MBC 55.1 mg/L 10.1007/s00044-011-9933-5
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1016/j.bmcl.2006.12.090
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1021/acs.jnatprod.2c00065
Staphylococcus aureus Staphylococcus aureus MBC50 3.9 ug ml-1 10.1016/j.bmcl.2014.12.029
Staphylococcus aureus Staphylococcus aureus MBC90 7.8 ug ml-1 10.1016/j.bmcl.2014.12.029
Staphylococcus aureus Staphylococcus aureus MIC 0.05 ug.mL-1 10.1021/jm00155a004
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.6b00935
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/np500827h
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2006.12.090
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1016/j.bmcl.2007.05.065
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1016/j.ejmech.2018.11.016
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/acsmedchemlett.5b00255
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/np4006025
Staphylococcus aureus Staphylococcus aureus MIC 0.8 ug.mL-1 10.1021/acs.jnatprod.9b01071
Staphylococcus aureus Staphylococcus aureus MIC 0.98 ug.mL-1 10.1039/C8MD00155C
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2007.03.060
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2006.11.010
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2007.05.013
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2007.09.008
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2007.11.026
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2010.03.027
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2013.07.041
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.1c00922
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.2c00801
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm00023a011
Staphylococcus aureus Staphylococcus aureus MIC 1.28 ug.mL-1 10.1016/j.ejmech.2010.01.066
Staphylococcus aureus Staphylococcus aureus MIC 1.5 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmc.2010.02.052
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmc.2011.06.021
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmc.2012.05.050
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmc.2013.02.008
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.bmc.2013.03.023
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.ejmech.2019.06.068
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1016/j.ejmech.2020.112352
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1021/acs.jnatprod.0c00161
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1021/jm500853v
Staphylococcus aureus Staphylococcus aureus MIC 1.6 ug.mL-1 10.1021/acs.jnatprod.1c01089
Staphylococcus aureus Staphylococcus aureus MIC 1.95 ug.mL-1 10.1016/j.bmc.2016.05.044
Staphylococcus aureus Staphylococcus aureus MIC 1.95 ug.mL-1 10.1016/j.ejmech.2018.11.016
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmc.2010.01.027
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmc.2010.02.005
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2005.04.066
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2011.08.095
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2015.03.033
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2016.02.024
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2009.03.006
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2016.12.008
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.1c00547
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c00065
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/jm501082n
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 2.34 ug.mL-1 10.1016/j.ejmech.2021.113202
Staphylococcus aureus Staphylococcus aureus MIC 2.34 ug.mL-1 10.1021/acs.jmedchem.9b00010
Staphylococcus aureus Staphylococcus aureus MIC 2.9 ug.mL-1 10.1016/j.bmcl.2014.12.029
Staphylococcus aureus Staphylococcus aureus MIC 3.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 3.1 uL/ml 10.1021/jm00200a016
Staphylococcus aureus Staphylococcus aureus MIC 3.12 ug.mL-1 10.1038/nature05756
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.02.006
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2008.12.034
Staphylococcus aureus Staphylococcus aureus MIC 3.13 ug.mL-1 10.1016/j.ejmech.2013.04.014
Staphylococcus aureus Staphylococcus aureus MIC 3.13 ug.mL-1 10.1016/j.ejmech.2020.112352
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/acs.jnatprod.2c00658
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/acs.jnatprod.8b00685
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/jf400718w
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/jm501082n
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00570-09
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 6.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/j.ejmech.2018.11.016
Staphylococcus aureus Staphylococcus aureus MIC 7.5 ug.mL-1 10.1021/acs.jnatprod.9b01015
Staphylococcus aureus Staphylococcus aureus MIC 7.8 ug.mL-1 10.1016/j.bmc.2019.05.012
Staphylococcus aureus Staphylococcus aureus MIC 7.8 ug.mL-1 10.1021/np030490j
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.02.005
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/jm00155a004
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/np300554f
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 10.0 ug.mL-1 10.1128/aac.00735-10
Staphylococcus aureus Staphylococcus aureus MIC 12.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1016/j.bmcl.2009.09.095
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1016/j.bmcl.2010.12.084
Staphylococcus aureus Staphylococcus aureus MIC 14.0 ug.mL-1 10.1021/np9805084
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.bmcl.2016.02.056
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2016.09.059
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.7b00176
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/acs.jnatprod.9b00654
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 24.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 30.0 ug.mL-1 10.1016/j.bmcl.2016.03.045
Staphylococcus aureus Staphylococcus aureus MIC 30.0 ug.mL-1 10.1016/j.bmcl.2016.11.056
Staphylococcus aureus Staphylococcus aureus MIC 31.0 ug.mL-1 10.1016/j.ejmech.2019.04.043
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.00570-09
Staphylococcus aureus Staphylococcus aureus MIC 33.0 ug.mL-1 10.1016/j.bmcl.2016.02.043
Staphylococcus aureus Staphylococcus aureus MIC 48.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/j.ejmech.2018.11.016
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/j.ejmech.2020.112352
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1021/jm500853v
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2006.12.090
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2016.12.060
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.7b00176
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.9b00654
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 80.0 ug.mL-1 10.1016/j.bmcl.2015.10.088
Staphylococcus aureus Staphylococcus aureus MIC 96.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/j.bmcl.2010.12.084
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1021/acs.jnatprod.9b01071
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1128/aac.00735-10
Staphylococcus aureus Staphylococcus aureus MIC 100.0 uL/ml 10.1021/jm00200a016
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1016/j.bmcl.2015.03.033
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1016/j.ejmech.2016.12.008
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1021/jm00155a004
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2022.114278
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/acsmedchemlett.5b00255
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/jm00023a011
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 140.0 ug.mL-1 10.1021/np9805084
Staphylococcus aureus Staphylococcus aureus MIC 200.0 nM 10.1016/j.bmcl.2023.129323
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.111639
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1128/aac.00328-07
Staphylococcus aureus Staphylococcus aureus MIC 500.0 ug.mL-1 10.1016/j.ejmech.2012.09.004
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 ug.mL-1 10.1016/j.bmc.2015.09.027
Staphylococcus aureus Staphylococcus aureus MIC 1560.0 nM None
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1021/acs.jnatprod.2c00967
Staphylococcus aureus Staphylococcus aureus MIC 2500.0 nM 10.1021/acsmedchemlett.5b00024
Staphylococcus aureus Staphylococcus aureus MIC 2800.0 nM 10.1021/np500735f
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1039/c8md00092a
Staphylococcus aureus Staphylococcus aureus MIC 8300.0 nM 10.1021/np5003252
Staphylococcus aureus Staphylococcus aureus MIC 50000.0 nM None
Staphylococcus aureus Staphylococcus aureus MIC 61900.0 nM 10.1016/j.ejmech.2018.04.039
Staphylococcus aureus Staphylococcus aureus MIC 128000.0 nM 10.1021/acsmedchemlett.0c00425
Staphylococcus aureus Staphylococcus aureus MIC 240000.0 nM 10.1021/np500735f
Staphylococcus aureus Staphylococcus aureus MIC 256000.0 nM 10.1039/c8md00092a
Staphylococcus aureus Staphylococcus aureus MIC 1024000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus MIC 2780000.0 nM 10.1039/C6MD00278A
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1016/j.bmc.2019.05.012
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/acs.jnatprod.0c00161
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1128/aac.01472-06
Staphylococcus aureus Staphylococcus aureus MIC nan None None
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1016/j.bmc.2011.01.051
Staphylococcus aureus Staphylococcus aureus MIC50 1.1 ug.mL-1 10.1016/j.ejmech.2011.07.047
Staphylococcus aureus Staphylococcus aureus MIC50 1.2 ug.mL-1 10.1016/j.bmc.2011.05.042
Staphylococcus aureus Staphylococcus aureus MIC50 1.5 ug.mL-1 10.1016/j.bmc.2013.06.066
Staphylococcus aureus Staphylococcus aureus MIC50 2.9 ug.mL-1 10.1016/j.bmcl.2014.12.029
Staphylococcus aureus Staphylococcus aureus MIC50 4.13 mmol/ml 10.1016/j.ejmech.2010.02.023
Staphylococcus aureus Staphylococcus aureus MIC50 30.0 ug.mL-1 10.1016/j.bmcl.2017.01.004
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1016/j.bmcl.2005.08.032
Staphylococcus aureus Staphylococcus aureus MIC90 5.8 ug.mL-1 10.1016/j.bmcl.2014.12.029
Staphylococcus aureus Staphylococcus aureus MIC90 7.8 ug.mL-1 10.1016/j.ejmech.2017.11.094
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1016/j.bmcl.2017.01.004
Staphylococcus aureus Staphylococcus aureus MIC90 30.0 ug.mL-1 10.1016/j.ejmech.2020.113102
Staphylococcus aureus Staphylococcus aureus MIC90 125.0 ug.mL-1 10.1016/j.ejmech.2017.11.094
Staphylococcus aureus Staphylococcus aureus MIC99 8.0 ug ml-1 10.1021/acs.jmedchem.5b01912
Staphylococcus aureus Staphylococcus aureus MIC99 9.12 ug ml-1 10.1016/j.ejmech.2018.11.012
Staphylococcus aureus Staphylococcus aureus OD 0.715 None 10.1016/j.ejmech.2018.11.012
Staphylococcus epidermidis Staphylococcus epidermidis DIZ nan None 10.1016/j.ejmech.2017.11.025
Staphylococcus epidermidis Staphylococcus epidermidis IC50 90.0 ug.mL-1 10.1021/np400473u
Staphylococcus epidermidis Staphylococcus epidermidis IC50 nan None 10.1016/j.ejmech.2018.04.039
Staphylococcus epidermidis Staphylococcus epidermidis IZ 8.3 mm 10.1016/j.ejmech.2018.11.012
Staphylococcus epidermidis Staphylococcus epidermidis IZ 20.5 mm 10.1016/j.bmcl.2015.04.048
Staphylococcus epidermidis Staphylococcus epidermidis MBC 25.0 mg/L 10.1007/s00044-011-9933-5
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.5b01375
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.1c01160
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1021/acs.jnatprod.2c00658
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.5 ug.mL-1 10.1016/j.bmc.2017.02.068
Staphylococcus epidermidis Staphylococcus epidermidis MIC 3.9 ug.mL-1 10.1016/j.bmcl.2016.02.024
Staphylococcus epidermidis Staphylococcus epidermidis MIC 62.5 ug.mL-1 10.1038/nature05756
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1021/jm501082n
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1021/np4006025
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus epidermidis Staphylococcus epidermidis MIC nan None 10.1016/j.ejmech.2018.04.039
Staphylococcus epidermidis Staphylococcus epidermidis MIC99 30.12 ug ml-1 10.1016/j.ejmech.2018.11.012
Staphylococcus haemolyticus Staphylococcus haemolyticus IZ 4.81 mm 10.1016/j.ejmech.2018.11.012
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC99 21.18 ug ml-1 10.1016/j.ejmech.2018.11.012
Staphylococcus saprophyticus Staphylococcus saprophyticus MBC 40.0 mg/L 10.1007/s00044-011-9933-5
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 0.25 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 0.5 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC50 0.25 ug.mL-1 10.1128/aac.01150-07
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC90 0.5 ug.mL-1 10.1128/aac.01150-07
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 8.0 ug.mL-1 10.1128/aac.00795-06
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 256.0 ug.mL-1 10.1128/aac.00795-06
Streptococcus equinus Streptococcus equinus MIC 128.0 ug.mL-1 10.1128/aac.00603-06
Streptococcus pasteurianus Streptococcus pasteurianus MIC 4096.0 ug.mL-1 10.1128/aac.00603-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1128/aac.01457-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 25000.0 nM None
Streptococcus pneumoniae Streptococcus pneumoniae MIC nan None None
Streptococcus pyogenes Streptococcus pyogenes MIC 12500.0 nM None
Streptococcus pyogenes Streptococcus pyogenes Ratio 16.0 None 10.1128/aac.00965-10
Streptomyces acidiscabies Streptomyces acidiscabies DIZ nan None 10.1584/jpestics.28.183
Streptomyces acidiscabies Streptomyces acidiscabies IZ 12.0 mm 10.1584/jpestics.28.183
Streptomyces acidiscabies Streptomyces acidiscabies IZ 18.0 mm 10.1584/jpestics.28.183
Streptomyces alboniger Streptomyces alboniger DIZ nan None 10.1584/jpestics.28.183
Streptomyces alboniger Streptomyces alboniger IZ 14.0 mm 10.1584/jpestics.28.183
Streptomyces coelicolor Streptomyces coelicolor MIC 0.5 ug.mL-1 10.1128/aac.00388-08
Streptomyces coelicolor Streptomyces coelicolor MIC 0.8 ug.mL-1 10.1128/aac.00388-08
Streptomyces coelicolor Streptomyces coelicolor MIC 1.0 ug.mL-1 10.1128/aac.00388-08
Streptomyces scabiei Streptomyces scabiei DIZ nan None 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 10.0 mm 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 13.0 mm 10.1584/jpestics.28.183
Streptomyces scabiei Streptomyces scabiei IZ 18.0 mm 10.1584/jpestics.28.183
Trichophyton mentagrophytes Trichophyton mentagrophytes IC50 7.8 ug.mL-1 10.1021/acs.jnatprod.6b00935
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 7.8 ug.mL-1 10.1021/np500827h
Trichophyton rubrum Trichophyton rubrum MIC 50.0 ug.mL-1 10.1016/j.ejmech.2006.11.010
Xanthomonas oryzae Xanthomonas oryzae IZ 0.0 mm 10.1016/j.ejmech.2012.10.038
Yersinia pseudotuberculosis Yersinia pseudotuberculosis Activity nan None 10.1021/acs.jnatprod.7b00694
Yersinia pseudotuberculosis Yersinia pseudotuberculosis GI nan None 10.1021/acs.jnatprod.7b00694
None ADMET CL 1.4 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET log10(%HIA +10) 1.041 None 10.1016/j.ejmech.2010.11.005
None ADMET MRT 3.1 hr 10.1124/dmd.108.020479
None ADMET T1/2 2.1 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.26 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LTKB_BD DILI severity score nan None 10.1016/j.drudis.2011.05.007
None Molecular identity unknown MIC nan None 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET Activity 16.0 ug ml-1 10.1128/aac.00652-07
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00382-07
None NON-PROTEIN TARGET EC50 6.5 ug.mL-1 10.1128/aac.00382-07
None NON-PROTEIN TARGET EC50 130.0 ug.mL-1 10.1128/aac.00382-07
None NON-PROTEIN TARGET Fu 0.99 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET MIC 0.3 ug.mL-1 10.1016/j.bmcl.2009.09.095
None NON-PROTEIN TARGET MIC 0.3 ug.mL-1 10.1016/j.bmcl.2010.12.084
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1021/np4006025
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1021/np300554f
None NON-PROTEIN TARGET MIC 3.13 ug.mL-1 10.1016/j.bmcl.2010.12.084
None NON-PROTEIN TARGET MIC 6.25 uL/ml 10.1021/jm00200a016
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00382-07
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.01615-09
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.00656-09
None NON-PROTEIN TARGET MIC 250.0 ug.mL-1 10.1128/aac.00261-06
None NON-PROTEIN TARGET MIC 250.0 ug.mL-1 10.1128/aac.00382-07
None NON-PROTEIN TARGET MIC 500.0 ug.mL-1 10.1128/aac.00261-06
None NON-PROTEIN TARGET MIC nan None 10.1016/j.ejmech.2016.09.059
None No relevant target Kinetic_solubility nan None 10.1016/j.ejmech.2012.08.047
None Nucleic Acid Kd 2080.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 2640.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 3460.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 13600.0 nM 10.1016/s0960-894x(02)00342-6
None Ribosomal RNA A-site IC50 100.0 nM 10.1021/acs.jmedchem.6b00793
None Unchecked Activity nan None 10.1016/j.bmc.2008.08.066
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c02140
None Unchecked Activity nan None 10.1039/C5MD00496A
None Unchecked Activity nan None 10.1128/aac.00106-10
None Unchecked Activity nan None 10.1128/aac.00382-07
None Unchecked FC 64.0 None 10.1021/acs.jmedchem.1c02140
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 80.0 nM 10.1021/jm010437x
None Unchecked IC50 3100.0 nM 10.1016/j.ejmech.2014.02.004
None Unchecked IC50 6300.0 nM 10.1016/j.ejmech.2013.05.004
None Unchecked IC50 6700.0 nM 10.1016/j.ejmech.2014.02.004
None Unchecked IC50 110610.0 nM 10.1021/acs.jmedchem.6b00793
None Unchecked IC50 nan None 10.1016/j.bmc.2017.02.068
None Unchecked IC50 nan None None
None Unchecked Inhibition 25.0 % 10.1016/j.ejmech.2019.112008
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.9b00091
None Unchecked IZ 9.3 mm 10.1016/j.ejmech.2019.05.081
None Unchecked Kcat 0.1 /s 10.1128/aac.01570-09
None Unchecked Kcat 0.32 /s 10.1128/aac.01570-09
None Unchecked Kcat/Km 2.3 10'5/s/M 10.1128/aac.01570-09
None Unchecked Kcat/Km 5.4 10'3/s/M 10.1128/aac.01570-09
None Unchecked Kd 1000000.0 nM 10.1016/j.bmc.2008.08.066
None Unchecked Ki nan None None
None Unchecked Km 18000.0 nM 10.1128/aac.01570-09
None Unchecked Km 151000.0 nM 10.1128/aac.01570-09
None Unchecked MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.055
None Unchecked Ratio 0.93 None 10.1016/j.bmcl.2022.128692
None Unchecked Ratio 1.14 None 10.1016/j.bmcl.2022.128692
None Unchecked Ratio 1.2 None 10.1016/j.bmcl.2022.128692
None Unchecked Ratio 1.23 None 10.1016/j.bmcl.2022.128692
None Unchecked Ratio IC50 1106.1 None 10.1021/acs.jmedchem.6b00793
None Unchecked Selectivity Index 154.0 None 10.1021/np400497f
None Unchecked Selectivity ratio 0.24 None 10.1016/j.ejmech.2020.112602
None Unchecked Selectivity ratio 4.0 None 10.1016/j.bmc.2010.02.005
None Unchecked Time nan None 10.1128/aac.00620-10
None Unchecked TIME 0.005556 hr 10.1128/aac.00620-10

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT004425 CC(=O)[32S].NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>CC(=O)NC1C(O)C(CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)C1O None
AKRT004426 CC(=O)[32S].NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>CC(=O)NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O None
AKRT004427 CC(=O)[32S].NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>CC(=O)N[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)O[C@H](CO)[C@H]1O None
AKRT004680 CC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>CC(=O)NC1C(O)C(CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)C1O enzymemap_32235
AKRT004681 CC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>CC(=O)NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O enzymemap_32245
AKRT004682 CC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>CC(=O)N[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@@H]1O enzymemap_32211
AKRT007191 CCC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>CCC(=O)N[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@@H]1O enzymemap_32197
AKRT007442 CCCC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>CCCC(=O)N[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@@H]1O enzymemap_32185
AKRT016486 N=c1[nH]c(=O)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2[nH]1.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>N=c1[nH]c(=O)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2[nH]1.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O None
AKRT017163 NC(=O)OP(=O)(O)O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](COC(N)=O)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O R10768
AKRT017166 NC(=O)OP(=O)(O)O.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](COC(N)=O)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O RXN-15285
AKRT017179 NC(=O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O RXN-13167
AKRT017182 NC(=O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](COC(N)=O)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O RXN-13167
AKRT017777 NCC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NCC(=O)N[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@@H]1O enzymemap_32188
AKRT018494 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.N[C@H]1[C@H](O)[C@@H](CO)O[C@H](OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](O)[C@@H]2O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O RXN-13125
AKRT018500 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)C(=O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O RXN-14402
AKRT018505 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O enzymemap_48912
AKRT018506 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](OP(=O)(O)O)[C@@H]1O enzymemap_45516
AKRT018507 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O enzymemap_43943
AKRT018510 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O enzymemap_48912
AKRT018518 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)C(=O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O None
AKRT018524 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1 None
AKRT018525 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](OP(=O)(O)O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT018526 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT018527 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O None
AKRT018528 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O RXN-16730
AKRT018530 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT018533 NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](COC(N)=O)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O RXN-13167
AKRT020476 N[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C=O)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O R11269
AKRT022711 O=C(O)CC(=O)[CoA].NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](NC(=O)CC(=O)O)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O enzymemap_32231