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name Structure Reference Source Properties Activities Metabolism

Saccharin

AlkaPlorer ID: AK004319

Synonym: None

IUPAC Name: 1,1-dioxo-1,2-benzothiazol-3-one

Structure

SMILES: O=C1NS(=O)(=O)C2=CC=CC=C12

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InChI: InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

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InChIKey: CVHZOJJKTDOEJC-UHFFFAOYSA-N

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Reference

PubChem CID: 176295044

CAS: 128-44-9

NPASS: NPC328793

COCONUT: CNP0151101

Source

Species Genus Family Order Class Phylum Kingdom Domain
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota

Properties Information

Molecule Weight: 183.188

TPSA？: 63.24

MolLogP？: 0.1186999999999999

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Anopheles gambiae AGAP002992-PA Ki 95.3 nM 10.1016/j.bmc.2015.03.081
Astrosclera willeyana Astrosclerin-3 Ki 751.0 nM 10.1016/j.bmc.2012.01.007
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 736.0 nM 10.1016/j.bmc.2009.05.002
Emericella nidulans RmtA IC50 510000.0 nM 10.1021/jm061213n
Homo sapiens Amyloid-beta A4 protein Activity nan None 10.1016/j.bmcl.2014.12.006
Homo sapiens Amyloid-beta A4 protein Inhibition 54.0 % 10.1016/j.bmcl.2014.12.006
Homo sapiens Butyrylcholinesterase IC50 3600.0 nM 10.1016/j.bmcl.2014.12.006
Homo sapiens Butyrylcholinesterase Inhibition 73.0 % 10.1016/j.bmcl.2014.12.006
Homo sapiens Carbonic anhydrase I Ki 10000.0 nM 10.1021/acs.jmedchem.9b01669
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2011.02.015
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2012.08.018
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2014.01.056
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2016.01.038
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmc.2017.04.007
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1021/acs.jmedchem.6b00616
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1021/jm301611m
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase I Ki 18540.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase I Ki 20000.0 nM 10.1021/acs.jmedchem.7b01470
Homo sapiens Carbonic anhydrase II Ki 5180.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2011.02.015
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2012.08.018
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2014.01.056
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2016.01.038
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmc.2017.04.007
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmcl.2009.10.009
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1021/acs.jmedchem.6b00616
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1021/acs.jmedchem.9b01669
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase II Ki 5950.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmcl.2013.11.021
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmcl.2015.06.079
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmcl.2016.01.023
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1021/jm301611m
Homo sapiens Carbonic anhydrase II Ki 5959.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase II Ki 6000.0 nM 10.1021/acs.jmedchem.7b01470
Homo sapiens Carbonic anhydrase II Ki 6000.0 nM 10.1021/acsmedchemlett.8b00100
Homo sapiens Carbonic anhydrase II Ki 7470.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase III Ki 1000000.0 nM 10.1016/j.bmc.2007.08.037
Homo sapiens Carbonic anhydrase IV Ki 7920.0 nM 10.1021/acs.jmedchem.9b01669
Homo sapiens Carbonic anhydrase IV Ki 7920.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase IX Ki 100.0 nM 10.1021/acs.jmedchem.7b01470
Homo sapiens Carbonic anhydrase IX Ki 100.0 nM 10.1021/acsmedchemlett.8b00100
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1016/j.bmc.2012.08.018
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1016/j.bmc.2014.01.056
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1016/j.bmc.2016.01.038
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1016/j.bmc.2017.04.007
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1021/acs.jmedchem.6b00616
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1021/acs.jmedchem.9b01669
Homo sapiens Carbonic anhydrase IX Ki 103.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase VA Ki 10060.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase VB Ki 7210.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase VI Ki 935.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase VI Ki 935.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase VII Ki 10.0 nM 10.1021/acs.jmedchem.6b00616
Homo sapiens Carbonic anhydrase VII Ki 10.0 nM 10.1021/acs.jmedchem.9b01669
Homo sapiens Carbonic anhydrase VII Ki 10.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1016/j.bmc.2014.01.056
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1016/j.bmc.2016.01.038
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1016/j.bmc.2017.04.007
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1016/j.bmcl.2007.11.025
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1021/acs.jmedchem.6b00616
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1021/acs.jmedchem.9b01669
Homo sapiens Carbonic anhydrase XII Ki 633.0 nM 10.1021/jm500255y
Homo sapiens Carbonic anhydrase XII Ki 650.0 nM 10.1021/acs.jmedchem.7b01470
Homo sapiens Carbonic anhydrase XIV Ki 773.0 nM 10.1021/jm500255y
Homo sapiens Fructose-1,6-bisphosphatase Inhibition nan % 10.1021/acs.jmedchem.2c00336
Homo sapiens Geminin Potency 0.8 nM None
Homo sapiens HERG Inhibition nan % 10.1021/acsmedchemlett.7b00137
Homo sapiens Histone deacetylase 6 Inhibition -12.02 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 27.21 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 22387.2 nM None
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 35481.3 nM None
Homo sapiens Homo sapiens Activity 0.88 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens F 84.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Ip 1.0 None 10.1021/jm00379a017
Homo sapiens Homo sapiens Pm 180.0 None 10.1021/jm00379a017
Homo sapiens Homo sapiens Pw 300.0 None 10.1021/jm00379a017
Homo sapiens Homo sapiens Sensory evaluation 3.0 None 10.1021/jm00379a017
Homo sapiens Homo sapiens Sensory evaluation 12.0 None 10.1021/jm00379a017
Homo sapiens Homo sapiens Sensory evaluation 85.0 None 10.1021/jm00379a017
Homo sapiens Liver CL 3.0 mL.min-1.g-1 10.1021/acsmedchemlett.7b00137
Homo sapiens Lysine-specific demethylase 4A Potency 89125.1 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 35481.3 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 68589.6 nM None
Homo sapiens Plasma Fu 0.37 None 10.1021/acsmedchemlett.7b00137
Homo sapiens Prelamin-A/C Potency 5.6 nM None
Homo sapiens Protein-arginine N-methyltransferase 1 IC50 510000.0 nM 10.1021/jm061213n
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 112.37 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 110.89 % 10.1124/mol.112.084152
Homo sapiens T1R1/T1R3 Activity nan None None
Homo sapiens Taste receptor type 2 member 31 EC50 650000.0 nM None
Homo sapiens Taste receptor type 2 member 31 Ratio 0.024 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 0.075 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 0.181 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 0.388 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 0.668 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 0.947 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 1.15 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 1.258 None None
Homo sapiens Taste receptor type 2 member 31 Ratio 1.354 None None
Homo sapiens Thyroid hormone receptor beta-1 Potency 2.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11885.6 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 19952.6 nM None
Homo sapiens Vitamin D receptor Potency 5.6 nM None
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2012.04.076
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.2c00336
Mus musculus Mus musculus Control 51.0 % 10.1021/jm00356a023
Mus musculus Mus musculus Control 67.0 % 10.1021/jm00356a023
Mus musculus Mus musculus Control 68.0 % 10.1021/jm00356a023
Mycobacterium tuberculosis Carbonic anhydrase Ki 792.0 nM 10.1016/j.bmcl.2009.10.009
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 7960.0 nM 10.1021/jm9003126
Rattus norvegicus Rattus norvegicus Inhibition 0.0 % 10.1021/jm00133a009
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1021/jm00133a009
Saccharomyces cerevisiae S288c Carbonic anhydrase Ki 12500.0 nM 10.1016/j.bmc.2008.12.035
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 2.333 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 10.23 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.1191 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.18 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.29 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 37.77 % 10.21203/rs.3.rs-23951/v1
Stylophora pistillata Alpha carbonic anhydrase Ki 40.3 nM 10.1016/j.bmc.2009.05.063
Stylophora pistillata Alpha carbonic anhydrase Ki 40.3 nM 10.1016/j.bmcl.2010.11.124
Stylophora pistillata Carbonic anhydrase Ki 104.0 nM 10.1016/j.bmcl.2010.11.124
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase Ki 876.0 nM 10.1016/j.bmcl.2015.11.104
Thalassiosira weissflogii Delta carbonic anhydrase Ki 9200.0 nM 10.1016/j.bmcl.2013.11.021
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family Ki 933.0 nM 10.1016/j.bmcl.2015.11.104
None ADMET AUC 14034.38 ng.hr.mL-1 10.1021/acs.jmedchem.2c00336
None ADMET Cmax 163327.69 nM 10.1021/acs.jmedchem.2c00336
None ADMET Cp nan None 10.1021/acs.jmedchem.2c00336
None ADMET log10(%HIA +10) 1.991 None 10.1016/j.ejmech.2010.11.005
None ADMET Papp 0.75 10'-6 cm/s 10.1021/acsmedchemlett.7b00137
None ADMET T1/2 1.11 hr 10.1021/acs.jmedchem.2c00336
None ADMET Tmax 0.25 hr 10.1021/acs.jmedchem.2c00336
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None No relevant target LogD -0.1 None 10.1021/acsmedchemlett.7b00137
None No relevant target pKa 1.3 None 10.1021/jm500255y
None No relevant target pKa 3.1 None 10.1021/acsmedchemlett.7b00137
None No relevant target Solubility 838000.0 nM 10.1021/acsmedchemlett.7b00137
None Unchecked Ac50 44.67 uM None
None Unchecked AC50 44668.4 nM None
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Ki 68.0 nM 10.1021/acsmedchemlett.0c00417
None Unchecked Ki 273.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 273.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 273.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 273.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 273.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 275.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 275.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 408.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 408.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 408.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 441.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 550.0 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 550.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 601.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 801.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 867.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 867.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 876.0 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 877.0 nM 10.1016/j.bmcl.2015.10.074
None Unchecked Ki 1000.0 nM 10.1021/jm301611m
None Unchecked Ki 1550.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 2244.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 3320.0 nM 10.1016/j.bmcl.2015.04.037
None Unchecked Ki 4780.0 nM 10.1016/j.bmc.2012.02.029
None Unchecked Ki 5390.0 nM 10.1016/j.bmc.2011.02.015
None Unchecked Ki 5390.0 nM 10.1016/j.bmcl.2015.10.074
None Unchecked Ki 7150.0 nM 10.1021/jm9003126
None Unchecked Ki 7810.0 nM 10.1016/j.bmc.2010.06.056
None Unchecked Ki 7960.0 nM 10.1021/jm9000488
None Unchecked Ki 8210.0 nM 10.1021/jm4000616
None Unchecked Ki 10000.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 14800.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 20500.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 26700.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 31500.0 nM 10.1016/j.bmc.2012.08.018
None Unchecked Ki 32000.0 nM 10.1016/j.bmc.2009.05.002
None Unchecked Ki 100000.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 100000.0 nM 10.1021/jm400939k
None Unchecked Ki nan None 10.1016/j.bmc.2012.07.024
None Unchecked Ki nan None 10.1016/j.bmc.2014.04.006
None Unchecked Ki nan None 10.1016/j.bmc.2014.07.048
None Unchecked Ki nan None 10.1016/j.bmc.2015.02.045
None Unchecked Ki nan None 10.1016/j.bmcl.2013.11.030
None Unchecked Ki nan None 10.1016/j.bmcl.2015.06.079
None Unchecked Ratio Ki 0.1 None 10.1021/jm500255y
None Unchecked Ratio Ki 2.4 None 10.1016/j.bmc.2010.06.056
None Unchecked Ratio Ki 6.1 None 10.1021/jm500255y
None Unchecked Ratio Ki 7.1 None 10.1021/jm500255y
None Unchecked Ratio Ki 9.1 None 10.1021/jm500255y
None Unchecked Ratio Ki 9.4 None 10.1021/jm500255y
None Unchecked Ratio Ki 29.3 None 10.1021/jm500255y
None Unchecked Ratio Ki 57.8 None 10.1021/jm500255y
None Unchecked Ratio Ki 70.0 None 10.1021/jm500255y
None Unchecked Ratio Ki 76.9 None 10.1021/jm500255y
None Unchecked Ratio Ki 97.7 None 10.1021/jm500255y
None Unchecked Ratio Ki 180.0 None 10.1021/jm500255y

Metabolism Information