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Eudistomin Y7

AlkaPlorer ID: AK004479

Synonym: None

IUPAC Name: (7-bromo-9H-pyrido[3,4-b]indol-1-yl)-(3,5-dibromo-4-hydroxyphenyl)methanone

Structure

SMILES: C1=CC2=C(C=C1Br)NC3=C2C=CN=C3C(=O)C4=CC(=C(C(=C4)Br)O)Br

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InChI: InChI=1S/C18H9Br3N2O2/c19-9-1-2-10-11-3-4-22-16(15(11)23-14(10)7-9)17(24)8-5-12(20)18(25)13(21)6-8/h1-7,23,25H

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InChIKey: JIBBXIBLZPCSSH-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 524.9940000000001

TPSA？: 65.98

MolLogP？: 5.940200000000002

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Bacillus subtilis Bacillus subtilis MIC 0.78 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Candida albicans MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Isocitrate lyase IC50 nan None 10.1016/j.bmc.2012.05.002
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Homo sapiens A549 LC50 59000.0 nM 10.1016/j.bmc.2012.05.002
Micrococcus luteus Micrococcus luteus MIC 1.56 ug.mL-1 10.1016/j.bmc.2012.05.002
Proteus vulgaris Proteus vulgaris MIC 0.78 ug.mL-1 10.1016/j.bmc.2012.05.002
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.78 ug.mL-1 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Sortase A IC50 190500.0 nM 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton rubrum Trichophyton rubrum MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
None Unchecked IC50 11300.0 nM 10.1016/j.bmc.2012.05.002

Metabolism Information