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Eudistomin Y4

AlkaPlorer ID: AK004602

Synonym: None

IUPAC Name: (3-bromo-4-hydroxyphenyl)-(6-bromo-9H-pyrido[3,4-b]indol-1-yl)methanone

Structure

SMILES: C1=CC(=C(C=C1C(=O)C2=NC=CC3=C2NC4=C3C=C(C=C4)Br)Br)O

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InChI: InChI=1S/C18H10Br2N2O2/c19-10-2-3-14-12(8-10)11-5-6-21-17(16(11)22-14)18(24)9-1-4-15(23)13(20)7-9/h1-8,22-23H

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InChIKey: AEXFJGQPZSMAKD-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 446.09799999999996

TPSA？: 65.98

MolLogP？: 5.177700000000002

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Bacillus subtilis Bacillus subtilis MIC 0.78 ug.mL-1 10.1016/j.bmc.2012.05.002
Bacillus subtilis Bacillus subtilis MIC 200.0 ug.mL-1 10.1021/np070064o
Candida albicans Candida albicans MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Isocitrate lyase IC50 nan None 10.1016/j.bmc.2012.05.002
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Homo sapiens A549 LC50 48400.0 nM 10.1016/j.bmc.2012.05.002
Micrococcus luteus Micrococcus luteus MIC 1.56 ug.mL-1 10.1016/j.bmc.2012.05.002
Proteus vulgaris Proteus vulgaris MIC 0.39 ug.mL-1 10.1016/j.bmc.2012.05.002
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.39 ug.mL-1 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Sortase A IC50 163200.0 nM 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton rubrum Trichophyton rubrum MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
None Unchecked IC50 7500.0 nM 10.1016/j.bmc.2012.05.002

Metabolism Information