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name Structure Reference Source Properties Activities Metabolism

Glycylleucine

AlkaPlorer ID: AK004622

Synonym: None

IUPAC Name: (2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoic acid

Structure

SMILES: CC(C)C[C@H](N=C(O)CN)C(=O)O

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InChI: InChI=1S/C8H16N2O3/c1-5(2)3-6(8(12)13)10-7(11)4-9/h5-6H,3-4,9H2,1-2H3,(H,10,11)(H,12,13)/t6-/m0/s1

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InChIKey: DKEXFJVMVGETOO-LURJTMIESA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota

Properties Information

Molecule Weight: 188.227

TPSA？: 95.91

MolLogP？: 0.4009000000000001

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 0

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Angiotensin-converting enzyme IC50 2511886.43 nM 10.1021/jm00014a022
Homo sapiens Oligopeptide transporter small intestine isoform Activity nan None 10.1172/jci4179
Homo sapiens Oligopeptide transporter small intestine isoform EC50 170000.0 nM 10.1021/jm0511029
Homo sapiens Oligopeptide transporter small intestine isoform IC50 70000.0 nM 10.1021/jm0511029
Homo sapiens Oligopeptide transporter small intestine isoform Inhibition 80.0 % None
Homo sapiens Oligopeptide transporter small intestine isoform Inhibition 93.0 % 10.1172/jci4179
Homo sapiens Oligopeptide transporter small intestine isoform Ki 160000.0 nM 10.1021/jm030976x
Homo sapiens Oligopeptide transporter small intestine isoform max activation 103.0 % 10.1021/jm0511029
Homo sapiens Oligopeptide transporter small intestine isoform Ratio 620.0 None 10.1021/jm0511029
Rattus norvegicus Oligopeptide transporter, kidney isoform Ki 6000.0 nM 10.1007/s004240000339
Rattus norvegicus Solute carrier family 15 member 1 Activity nan None None
Rattus norvegicus Solute carrier family 15 member 1 Ki 110000.0 nM 10.1007/s004240000339
Saccharomyces cerevisiae General amino-acid permease GAP1 Activity nan None 10.1038/nchembio.132
Saccharomyces cerevisiae General amino-acid permease GAP1 Inhibition 15.0 % 10.1038/nchembio.132
None No relevant target LogP 2.55 None 10.1021/jm00393a031
None Unchecked Log 1/T 1.68 None 10.1021/jm00014a022
None Unchecked Log 1/T 1.68 None 10.1021/jm00393a031

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT005647 CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O>>CC(C)C[C@H](NC(=O)CN)C(=O)O enzymemap_69202
AKRT005766 CC(C)C[C@H](N)C(=O)O.NCC(=O)O>>CC(C)C[C@H](NC(=O)CN)C(=O)O MNXR191126
AKRT005853 CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O>>CC(C)C[C@H](NC(=O)CN)C(=O)O enzymemap_74011
AKRT005856 CC(C)C[C@H](NC(=O)CN)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O>>CC(C)C[C@@H](NC(=O)CNC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(=O)O MNXR163063
AKRT005857 CC(C)C[C@H](NC(=O)CN)C(=O)O>>CC(C)C[C@H](N)C(=O)O enzymemap_64744
AKRT005858 CC(C)C[C@H](NC(=O)CN)C(=O)O>>CC(C)C[C@H](N)C(=O)O.NCC(=O)O None
AKRT005859 CC(C)C[C@H](NC(=O)CN)C(=O)O>>NCC(=O)O enzymemap_64744
AKRT005860 CC(C)C[C@H](NC(=O)CN)C(N)=O>>CC(C)C[C@H](NC(=O)CN)C(=O)O enzymemap_66633
AKRT005867 CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O>>CC(C)C[C@H](NC(=O)CN)C(=O)O enzymemap_64760
AKRT009728 CCOC(=O)[C@H](CC(C)C)NC(=O)CN>>CC(C)C[C@H](NC(=O)CN)C(=O)O enzymemap_66678
AKRT012527 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O>>CC(C)C[C@H](NC(=O)CN)C(=O)O enzymemap_67147