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name Structure Reference Source Properties Activities Metabolism

Glycyl-glycine

AlkaPlorer ID: AK004741

Synonym: None

IUPAC Name: 2-[(2-aminoacetyl)amino]acetic acid

Structure

SMILES: NCC(O)=NCC(=O)O

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InChI: InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)

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InChIKey: YMAWOPBAYDPSLA-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota

Properties Information

Molecule Weight: 132.119

TPSA？: 95.91

MolLogP？: -1.0137999999999998

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 0

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Angiotensin-converting enzyme IC50 7244359.6 nM 10.1021/jm00014a022
Homo sapiens Olfactory receptor 51E2 EC50 11000.0 nM None
Homo sapiens Olfactory receptor 51E2 Ratio 1.797 None None
Homo sapiens Oligopeptide transporter small intestine isoform EC50 480000.0 nM 10.1021/jm0511029
Homo sapiens Oligopeptide transporter small intestine isoform IC50 820000.0 nM 10.1021/jm0511029
Homo sapiens Oligopeptide transporter small intestine isoform Inhibition 80.0 % None
Homo sapiens Oligopeptide transporter small intestine isoform Ki 1000000.0 nM 10.1021/jm030976x
Homo sapiens Oligopeptide transporter small intestine isoform Ki 1000000.0 nM 10.1021/jm048982w
Homo sapiens Oligopeptide transporter small intestine isoform max activation 112.0 % 10.1021/jm0511029
Homo sapiens Oligopeptide transporter small intestine isoform Ratio 230.0 None 10.1021/jm0511029
Homo sapiens Solute carrier family 15 member 2 Ki 53703.18 nM 10.1016/j.bmc.2011.06.027
Homo sapiens Solute carrier family 15 member 2 Ki 54000.0 nM 10.1016/j.bmc.2011.06.027
Rattus norvegicus Oligopeptide transporter, kidney isoform Activity nan None 10.1152/ajpcell.1998.275.4.c967
Rattus norvegicus Oligopeptide transporter, kidney isoform Ki 42000.0 nM 10.1007/s004240000339
Rattus norvegicus Solute carrier family 15 member 1 Ki 860000.0 nM 10.1007/s004240000339
Saccharomyces cerevisiae General amino-acid permease GAP1 Inhibition 15.0 % 10.1038/nchembio.132
None No relevant target LogP 3.81 None 10.1021/jm00393a031
None Unchecked Inhibition nan % 10.1021/jm201517a
None Unchecked Log 1/T nan None 10.1021/jm00393a031

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT002441 CC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)O.NCC(=O)NCC(=O)O>>CC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@H](C)C(=O)NCC(=O)NCC(=O)O enzymemap_67350
AKRT005476 CC(C)CC(N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64910
AKRT005565 CC(C)C[C@@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_66299
AKRT005582 CC(C)C[C@@H](NC(=O)CNC(=O)CN)C(=O)O>>NCC(=O)NCC(=O)O enzymemap_66300
AKRT005620 CC(C)C[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64742
AKRT005763 CC(C)C[C@H](N)C(=O)O.NCC(=O)NCC(=O)O>>CC(C)CC(N)C(O)=NCC(O)=NCC(=O)O MNXR129883
AKRT005836 CC(C)C[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32896
AKRT005890 CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_67185
AKRT006043 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)O>>NCC(=O)NCC(=O)O enzymemap_75787
AKRT006201 CC(C)[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64985
AKRT006357 CC(C)[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32811
AKRT006522 CC(N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64909
AKRT006535 CC(N)C(O)=NCC(O)=NCC(=O)O>>NCC(=O)NCC(=O)O MNXR129986
AKRT006626 CC(O)CC(=O)NCC(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_67158
AKRT007690 CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O.NCC(=O)NCC(=O)O>>CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O enzymemap_32899
AKRT009710 CCOC(=O)CNC(=O)CN>>NCC(=O)NCC(=O)O enzymemap_66679
AKRT010432 CN(C)c1cccc2c(S(=O)(=O)NCC(=O)NCC(=O)NCC(=O)O)cccc12>>NCC(=O)NCC(=O)O enzymemap_67227
AKRT011585 COc1cc(NC(=O)CC[C@H](N)C(=O)O)cc2ccccc12.NCC(=O)NCC(=O)O>>COc1cc(N)cc2ccccc12.N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O None
AKRT011586 COc1cc(NC(=O)CC[C@H](N)C(=O)O)cc2ccccc12.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32762
AKRT012096 CSCCC(N)C(O)=NCC(O)=NCC(=O)O>>NCC(=O)NCC(=O)O MNXR130223
AKRT012253 CSCC[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64984
AKRT012457 CSCC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32807
AKRT012704 C[C@@H](N)C(=O)NCC(=O)NCC(=O)O>>C[C@@H](N)C(=O)O.NCC(=O)NCC(=O)O None
AKRT012705 C[C@@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_65275
AKRT012747 C[C@@H](N)C(=O)O.NCC(=O)NCC(=O)O>>C[C@@H](N)C(=O)NCC(=O)NCC(=O)O MNXR130811
AKRT013411 C[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64981
AKRT013866 C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)O>>NCC(=O)NCC(=O)O enzymemap_67272
AKRT014876 Cc1cc(=O)oc2cc(NC(=O)CC[C@H](N)C(=O)O)ccc12.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32768
AKRT015972 N=C(N)NCCC[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64759
AKRT016026 N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)NCC(=O)O>>N=C(N)NCCC[C@@H](N)C(=O)NCC(=O)NCC(=O)O MNXR154726
AKRT016119 N=C(N)NCCC[C@H](NC(=O)CNC(=O)CN)C(=O)O>>N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)NCC(=O)O None
AKRT016120 N=C(N)NCCC[C@H](NC(=O)CNC(=O)CN)C(=O)O>>NCC(=O)NCC(=O)O enzymemap_67611
AKRT016185 N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)CN)C(=O)O>>NCC(=O)NCC(=O)O enzymemap_67186
AKRT017504 NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_66744
AKRT017541 NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_75768
AKRT017542 NCC(=O)NCC(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_66683
AKRT017543 NCC(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_65287
AKRT017544 NCC(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O.NCC(=O)O None
AKRT017549 NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(N)=O>>NCC(=O)NCC(=O)O enzymemap_66647
AKRT017550 NCC(=O)NCC(=O)O.NC(=O)CC[C@H](N)C(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32759
AKRT017551 NCC(=O)NCC(=O)O.NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)NCC(=O)NCC(=O)O enzymemap_67080
AKRT017552 NCC(=O)NCC(=O)O.NCC(=O)O>>NCC(=O)NCC(=O)NCC(=O)O MNXR129876
AKRT017553 NCC(=O)NCC(=O)O.NCCCC[C@H](N)C(=O)O>>NCCCCC(N)C(O)=NCC(O)=NCC(=O)O MNXR131610
AKRT017554 NCC(=O)NCC(=O)O.N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O RXN-18092
AKRT017555 NCC(=O)NCC(=O)O.N[C@@H](CCC(=O)Nc1ccc([N+](=O)O)cc1)C(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O RXN-18093
AKRT017556 NCC(=O)NCC(=O)O.N[C@@H](CCC(=O)Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)C(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O.Nc1ccc([N+](=O)[O-])c(C(=O)O)c1 None
AKRT017557 NCC(=O)NCC(=O)O.N[C@@H](CCC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O.Nc1ccc([N+](=O)[O-])cc1 None
AKRT017558 NCC(=O)NCC(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O>>NC(Cc1ccc(O)cc1)C(O)=NCC(O)=NCC(=O)O MNXR129877
AKRT017559 NCC(=O)NCC(=O)O.N[C@@H](Cc1ccccc1)C(=O)O>>NC(Cc1ccccc1)C(O)=NCC(O)=NCC(=O)O MNXR129980
AKRT017560 NCC(=O)NCC(=O)O>>NCC(=O)O MNXR100956
AKRT017561 NCC(=O)NCC(=O)O>>NCC(=O)O.NCC(=O)O None
AKRT017562 NCC(=O)NCC(=O)O>>O=C1CNC(=O)CN1 25-DIOXOPIPERAZINE-HYDROLASE-RXN
AKRT017634 NCC(=O)O.NCC(=O)O>>NCC(=O)NCC(=O)O MNXR100345
AKRT018062 NCCCC[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_65089
AKRT018063 NCCCC[C@H](N)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O.NCCCC[C@H](N)C(=O)O None
AKRT018612 N[C@@H](CC(=O)NCC(=O)NCC(=O)O)C(=O)O>>NCC(=O)NCC(=O)O enzymemap_68267
AKRT018812 N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CS)C(=O)NCC(=O)O enzymemap_32756
AKRT018908 N[C@@H](CCC(=O)N[C@@H](CS)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32779
AKRT018955 N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CSN=O)C(=O)NCC(=O)O enzymemap_32753
AKRT018985 N[C@@H](CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32809
AKRT018987 N[C@@H](CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32810
AKRT018989 N[C@@H](CCC(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32808
AKRT018992 N[C@@H](CCC(=O)N[C@H](CSN=O)C(=O)NCC(=O)O)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CSN=O)C(=O)NCC(=O)O enzymemap_32753
AKRT018995 N[C@@H](CCC(=O)Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32822
AKRT019004 N[C@@H](CCC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32758
AKRT019021 N[C@@H](CCC(=O)Nc1ccc2ccccc2c1)C(=O)O.NCC(=O)NCC(=O)O>>N[C@@H](CCC(=O)NCC(=O)NCC(=O)O)C(=O)O enzymemap_32846
AKRT019436 N[C@@H](CO)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O MNXR130001
AKRT019570 N[C@@H](CS)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_65444
AKRT019912 N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_65892
AKRT020016 N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)O>>NCC(=O)NCC(=O)O enzymemap_64980
AKRT022845 O=C(O)CNC(=O)CNC(=O)CNC(=O)OCc1ccccc1>>NCC(=O)NCC(=O)O enzymemap_67184
AKRT022852 O=C(O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1>>NCC(=O)NCC(=O)O enzymemap_67178
AKRT022855 O=C(O)CNC(=O)CNC(=O)[C@@H]1CCCN1>>NCC(=O)NCC(=O)O enzymemap_64978
AKRT022856 O=C(O)CNC(=O)CNC(=O)[C@@H]1CCCN1>>NCC(=O)NCC(=O)O.O=C(O)[C@@H]1CCCN1 None
AKRT022858 O=C(O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C=C/c1ccco1>>NCC(=O)NCC(=O)O enzymemap_67164
AKRT022859 O=C(O)CNC(=O)CNCc1ccccc1>>NCC(=O)NCC(=O)O enzymemap_77659
AKRT023567 O=C1CNC(=O)CN1>>NCC(=O)NCC(=O)O 25-DIOXOPIPERAZINE-HYDROLASE-RXN