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name Structure Reference Source Properties Activities Metabolism

Cocaine

AlkaPlorer ID: AK004884

Synonym: None

IUPAC Name: methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azoniabicyclo[3.2.1]octane-2-carboxylate

Structure

SMILES: COC(=O)[C@H]1[C@@H](OC(=O)C2=CC=CC=C2)C[C@@H]2CC[C@H]1[NH+]2C

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InChI: InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/p+1/t12-,13+,14-,15+/m0/s1

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InChIKey: ZPUCINDJVBIVPJ-LJISPDSOSA-O

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Properties Information

Molecule Weight: 304.36600000000004

TPSA？: 57.04

MolLogP？: 0.4505999999999999

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Bos taurus IC50 843.0 nM 10.1021/jm00169a036
Bos taurus Dopamine transporter IC50 65.0 nM 10.1021/jm00106a035
Bos taurus Dopamine transporter IC50 139.0 nM 10.1021/jm00169a036
Cavia porcellus Sigma-1 receptor Inhibition nan % 10.1021/jm200144j
Cercopithecidae Monkey IC50 70.0 nM 10.1021/jm00090a005
Cercopithecidae Monkey Peak striatal uptake 0.06 None 10.1021/jm00090a005
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase Km 120000.0 nM 10.1016/j.bmc.2009.10.052
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase pKm 3.92 None 10.1016/j.bmc.2009.10.052
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter EC50 nan None 10.1021/acs.jmedchem.7b00141
Homo sapiens Dopamine transporter IC50 89.1 nM 10.1016/j.bmc.2008.04.008
Homo sapiens Dopamine transporter IC50 89.1 nM 10.1016/j.bmc.2009.05.052
Homo sapiens Dopamine transporter IC50 89.1 nM 10.1021/jm0401311
Homo sapiens Dopamine transporter IC50 89.1 nM 10.1021/jm0582423
Homo sapiens Dopamine transporter IC50 89.1 nM 10.1021/jm060287w
Homo sapiens Dopamine transporter IC50 95.6 nM 10.1021/jm00059a010
Homo sapiens Dopamine transporter IC50 130.0 nM 10.1128/aac.00669-07
Homo sapiens Dopamine transporter IC50 190.0 nM 10.1021/jm990161h
Homo sapiens Dopamine transporter IC50 190.0 nM 10.1021/jm9902178
Homo sapiens Dopamine transporter IC50 227.0 nM 10.1016/j.bmc.2009.08.025
Homo sapiens Dopamine transporter IC50 240.0 nM 10.1021/jm0608614
Homo sapiens Dopamine transporter IC50 259.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 267.0 nM 10.1016/s0960-894x(03)00386-x
Homo sapiens Dopamine transporter IC50 267.0 nM 10.1021/jm901189z
Homo sapiens Dopamine transporter IC50 274.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Dopamine transporter IC50 283.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 289.0 nM 10.1021/jm0490989
Homo sapiens Dopamine transporter IC50 296.0 nM 10.1021/jm010302r
Homo sapiens Dopamine transporter IC50 301.0 nM 10.1016/s0960-894x(99)00685-x
Homo sapiens Dopamine transporter IC50 303.0 nM 10.1016/j.bmc.2008.10.065
Homo sapiens Dopamine transporter IC50 303.0 nM 10.1021/jm8010993
Homo sapiens Dopamine transporter IC50 330.0 nM 10.1016/j.bmcl.2003.07.014
Homo sapiens Dopamine transporter IC50 366.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 367.0 nM 10.1021/jm0490989
Homo sapiens Dopamine transporter IC50 392.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 405.0 nM 10.1021/jm9508797
Homo sapiens Dopamine transporter IC50 461.0 nM 10.1021/jm050797a
Homo sapiens Dopamine transporter IC50 478.0 nM 10.1021/jm701270n
Homo sapiens Dopamine transporter IC50 507.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 590.0 nM 10.1016/j.bmc.2009.01.023
Homo sapiens Dopamine transporter IC50 645.65 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Dopamine transporter IC50 670.0 nM 10.1016/j.bmcl.2010.11.076
Homo sapiens Dopamine transporter IC50 759.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 1060.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter IC50 1172.0 nM 10.1074/jbc.m610633200
Homo sapiens Dopamine transporter Ki 32.0 nM 10.1021/jm9508797
Homo sapiens Dopamine transporter Ki 200.0 nM 10.1021/acs.jmedchem.6b01373
Homo sapiens Dopamine transporter Ki 223.0 nM 10.1021/acs.jmedchem.6b01373
Homo sapiens Dopamine transporter Ki 231.0 nM 10.1021/jm990516x
Homo sapiens Dopamine transporter Ki 234.42 nM 10.1016/j.bmcl.2005.02.012
Homo sapiens Dopamine transporter Ki 249.0 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Dopamine transporter Ki 258.0 nM 10.1021/jm0001121
Homo sapiens Dopamine transporter Ki 270.0 nM 10.1016/s0960-894x(02)00943-5
Homo sapiens Dopamine transporter Ki 272.0 nM 10.1016/s0960-894x(03)00386-x
Homo sapiens Dopamine transporter Ki 272.0 nM 10.1021/jm901189z
Homo sapiens Dopamine transporter Ki 276.0 nM 10.1021/jm0001121
Homo sapiens Dopamine transporter Ki 300.0 nM 10.1021/jm000201d
Homo sapiens Dopamine transporter Ki 330.0 nM 10.1021/jm000201d
Homo sapiens Dopamine transporter Ki 341.0 nM 10.1021/jm701270n
Homo sapiens Dopamine transporter Ki 347.0 nM 10.1016/j.bmc.2007.03.069
Homo sapiens Dopamine transporter Ki 371.0 nM 10.1016/j.bmc.2008.10.065
Homo sapiens Dopamine transporter Ki 371.0 nM 10.1016/j.bmc.2009.01.023
Homo sapiens Dopamine transporter Ki 371.0 nM 10.1021/jm8010993
Homo sapiens Dopamine transporter Ki 388.0 nM 10.1021/jm9508797
Homo sapiens Dopamine transporter Ki 419.0 nM 10.1016/j.bmcl.2003.07.014
Homo sapiens Dopamine transporter Ki 431.0 nM 10.1016/j.bmc.2009.08.025
Homo sapiens Dopamine transporter Ki 432.0 nM 10.1021/jm050797a
Homo sapiens Dopamine transporter Ki 450.0 nM 10.1021/acs.jmedchem.9b01188
Homo sapiens Dopamine transporter Ki 490.0 nM 10.1021/jm010302r
Homo sapiens Dopamine transporter Ki 500.0 nM 10.1021/jm0608614
Homo sapiens Dopamine transporter Ki 630.0 nM 10.1016/j.bmc.2007.03.069
Homo sapiens Dopamine transporter Ki 720.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Dopamine transporter Ki 759.0 nM 10.1021/jm990161h
Homo sapiens Dopamine transporter Ki 760.0 nM 10.1021/jm9902178
Homo sapiens Dopamine transporter Ki 1270.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Dopamine transporter Ratio 1.0 None 10.1016/s0960-894x(03)00386-x
Homo sapiens Dopamine transporter Ratio 1.1 None 10.1021/jm000201d
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GABA-A receptor; anion channel IC50 127000.0 nM 10.1021/jm9904349
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 4.4 nM 10.1021/jm0208875
Homo sapiens HERG IC50 5754.4 nM 10.1016/j.bmcl.2005.01.008
Homo sapiens HERG IC50 5754.4 nM 10.1016/j.ejmech.2008.11.009
Homo sapiens HERG IC50 7244.36 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 7244.36 nM 10.1016/j.bmcl.2005.03.080
Homo sapiens HERG IC50 7244.36 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Homo sapiens CL 32.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.4 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Kappa opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 18999.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Ratio 0.2 None 10.1021/jm0001121
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Ratio 0.58 None 10.1021/jm000201d
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Ratio 4.0 None 10.1021/jm010302r
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Ratio Ki 0.88 None 10.1021/jm0608614
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Ratio Ki 1.0 None 10.1021/jm0608614
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Selectivity 6.36 None 10.1016/s0960-894x(01)00443-7
Homo sapiens Monoamine transporters; Norepinephrine & dopamine Selectivity nan None 10.1021/jm020275k
Homo sapiens Monoamine transporters; serotonin & dopamine Ratio 0.37 None 10.1021/jm0001121
Homo sapiens Monoamine transporters; serotonin & dopamine Ratio 0.7 None 10.1021/jm010302r
Homo sapiens Monoamine transporters; serotonin & dopamine Ratio 0.94 None 10.1021/jm000201d
Homo sapiens Monoamine transporters; serotonin & dopamine Ratio 1.4 None 10.1016/s0960-894x(99)00685-x
Homo sapiens Monoamine transporters; serotonin & dopamine Ratio 6.6 None 10.1021/jm990306k
Homo sapiens Monoamine transporters; serotonin & dopamine Selectivity 2.7 None 10.1016/s0960-894x(01)00443-7
Homo sapiens Monoamine transporters; serotonin & dopamine Selectivity nan None 10.1021/jm020275k
Homo sapiens Monoclonal antibody (mAb) 2E2 Kd 4.4 nM 10.1021/jm030351z
Homo sapiens Monoclonal antibody (mAb) 2E2 Ki 3.5 nM 10.1021/jm030351z
Homo sapiens Monoclonal antibody (mAb) 2E2 RBA 1.0 None 10.1021/jm030351z
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter EC50 nan None 10.1021/acs.jmedchem.7b00141
Homo sapiens Norepinephrine transporter IC50 186.0 nM 10.1016/s0960-894x(99)00685-x
Homo sapiens Norepinephrine transporter IC50 192.0 nM 10.1016/j.bmcl.2003.07.014
Homo sapiens Norepinephrine transporter IC50 210.0 nM 10.1021/jm0608614
Homo sapiens Norepinephrine transporter IC50 221.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Norepinephrine transporter IC50 230.0 nM 10.1021/jm990161h
Homo sapiens Norepinephrine transporter IC50 230.0 nM 10.1021/jm9902178
Homo sapiens Norepinephrine transporter IC50 232.0 nM 10.1016/j.bmc.2009.08.025
Homo sapiens Norepinephrine transporter IC50 233.0 nM 10.1021/jm010302r
Homo sapiens Norepinephrine transporter IC50 378.0 nM 10.1021/jm050797a
Homo sapiens Norepinephrine transporter IC50 385.0 nM 10.1016/s0960-894x(03)00386-x
Homo sapiens Norepinephrine transporter IC50 385.0 nM 10.1021/jm901189z
Homo sapiens Norepinephrine transporter IC50 462.0 nM 10.1021/jm0490989
Homo sapiens Norepinephrine transporter IC50 835.0 nM 10.1016/j.bmc.2008.10.065
Homo sapiens Norepinephrine transporter IC50 835.0 nM 10.1021/jm8010993
Homo sapiens Norepinephrine transporter IC50 900.0 nM 10.1021/jm0601654
Homo sapiens Norepinephrine transporter IC50 1281.0 nM 10.1016/j.bmc.2009.01.023
Homo sapiens Norepinephrine transporter IC50 1900.0 nM 10.1128/aac.00669-07
Homo sapiens Norepinephrine transporter IC50 2990.0 nM 10.1021/jm0490989
Homo sapiens Norepinephrine transporter IC50 3300.0 nM 10.1021/jm0401311
Homo sapiens Norepinephrine transporter IC50 3300.0 nM 10.1021/jm0582423
Homo sapiens Norepinephrine transporter IC50 3300.0 nM 10.1021/jm060287w
Homo sapiens Norepinephrine transporter IC50 6309.57 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Norepinephrine transporter Ki 108.0 nM 10.1016/s0960-894x(02)00943-5
Homo sapiens Norepinephrine transporter Ki 182.0 nM 10.1016/j.bmc.2007.03.069
Homo sapiens Norepinephrine transporter Ki 190.0 nM 10.1021/jm000201d
Homo sapiens Norepinephrine transporter Ki 264.0 nM 10.1021/jm0001121
Homo sapiens Norepinephrine transporter Ki 500.0 nM 10.1021/jm0608614
Homo sapiens Norepinephrine transporter Ki 645.0 nM 10.1016/j.bmcl.2003.07.014
Homo sapiens Norepinephrine transporter Ki 830.0 nM 10.1016/s0960-894x(03)00386-x
Homo sapiens Norepinephrine transporter Ki 830.0 nM 10.1021/jm901189z
Homo sapiens Norepinephrine transporter Ki 887.0 nM 10.1016/j.bmc.2007.03.069
Homo sapiens Norepinephrine transporter Ki 1115.0 nM 10.1016/j.bmc.2008.10.065
Homo sapiens Norepinephrine transporter Ki 1115.0 nM 10.1021/jm8010993
Homo sapiens Norepinephrine transporter Ki 1116.0 nM 10.1016/j.bmc.2009.01.023
Homo sapiens Norepinephrine transporter Ki 1257.0 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Norepinephrine transporter Ki 1740.0 nM 10.1021/jm0001121
Homo sapiens Norepinephrine transporter Ki 1770.0 nM 10.1021/jm990161h
Homo sapiens Norepinephrine transporter Ki 1770.0 nM 10.1021/jm9902178
Homo sapiens Norepinephrine transporter Ki 1940.0 nM 10.1021/jm010302r
Homo sapiens Norepinephrine transporter Ki 1990.0 nM 10.1016/j.bmc.2008.04.008
Homo sapiens Norepinephrine transporter Ki 1990.0 nM 10.1016/j.bmc.2009.05.052
Homo sapiens Norepinephrine transporter Ki 1990.0 nM 10.1021/jm0401311
Homo sapiens Norepinephrine transporter Ki 1990.0 nM 10.1021/jm0582423
Homo sapiens Norepinephrine transporter Ki 1990.0 nM 10.1021/jm060287w
Homo sapiens Norepinephrine transporter Ki 2150.0 nM 10.1021/jm050797a
Homo sapiens Norepinephrine transporter Ki 2357.0 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Norepinephrine transporter Ki 2377.0 nM 10.1016/j.bmc.2009.08.025
Homo sapiens Norepinephrine transporter Ki 2410.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Norepinephrine transporter Ki 2700.0 nM 10.1021/jm000201d
Homo sapiens Norepinephrine transporter Ki 10700.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Norepinephrine transporter Ratio 0.46 None 10.1016/s0960-894x(03)00386-x
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin and norepinephrine transporters (SERT/NET) Ratio 0.7 None 10.1021/jm0001121
Homo sapiens Serotonin and norepinephrine transporters (SERT/NET) Ratio 2.2 None 10.1016/s0960-894x(99)00685-x
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter EC50 nan None 10.1021/acs.jmedchem.7b00141
Homo sapiens Serotonin transporter IC50 180.0 nM 10.1128/aac.00669-07
Homo sapiens Serotonin transporter IC50 250.0 nM 10.1021/jm0608614
Homo sapiens Serotonin transporter IC50 270.0 nM 10.1016/s0960-894x(99)00098-0
Homo sapiens Serotonin transporter IC50 270.0 nM 10.1021/jm00059a010
Homo sapiens Serotonin transporter IC50 277.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Serotonin transporter IC50 289.0 nM 10.1021/jm0490989
Homo sapiens Serotonin transporter IC50 304.0 nM 10.1021/jm701270n
Homo sapiens Serotonin transporter IC50 318.0 nM 10.1016/s0960-894x(03)00386-x
Homo sapiens Serotonin transporter IC50 318.0 nM 10.1021/jm901189z
Homo sapiens Serotonin transporter IC50 325.0 nM 10.1016/j.bmcl.2003.07.014
Homo sapiens Serotonin transporter IC50 336.0 nM 10.1021/jm990161h
Homo sapiens Serotonin transporter IC50 338.0 nM 10.1016/j.bmc.2009.08.025
Homo sapiens Serotonin transporter IC50 338.0 nM 10.1021/jm010302r
Homo sapiens Serotonin transporter IC50 340.0 nM 10.1021/jm9902178
Homo sapiens Serotonin transporter IC50 413.0 nM 10.1016/s0960-894x(99)00685-x
Homo sapiens Serotonin transporter IC50 416.0 nM 10.1016/j.bmc.2008.10.065
Homo sapiens Serotonin transporter IC50 416.0 nM 10.1021/jm8010993
Homo sapiens Serotonin transporter IC50 433.0 nM 10.1021/jm0490989
Homo sapiens Serotonin transporter IC50 494.0 nM 10.1021/jm050797a
Homo sapiens Serotonin transporter IC50 540.0 nM 10.1016/j.bmcl.2010.11.076
Homo sapiens Serotonin transporter IC50 642.0 nM 10.1016/j.bmc.2009.01.023
Homo sapiens Serotonin transporter IC50 1050.0 nM 10.1021/jm0401311
Homo sapiens Serotonin transporter IC50 1050.0 nM 10.1021/jm0582423
Homo sapiens Serotonin transporter IC50 1050.0 nM 10.1021/jm060287w
Homo sapiens Serotonin transporter IC50 2398.83 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin transporter Ki 45.0 nM 10.1021/jm0401311
Homo sapiens Serotonin transporter Ki 45.0 nM 10.1021/jm0582423
Homo sapiens Serotonin transporter Ki 45.0 nM 10.1021/jm060287w
Homo sapiens Serotonin transporter Ki 95.0 nM 10.1016/j.bmc.2008.04.008
Homo sapiens Serotonin transporter Ki 95.0 nM 10.1016/j.bmc.2009.05.052
Homo sapiens Serotonin transporter Ki 129.0 nM 10.1021/jm701270n
Homo sapiens Serotonin transporter Ki 155.0 nM 10.1016/s0960-894x(02)00943-5
Homo sapiens Serotonin transporter Ki 229.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Serotonin transporter Ki 276.0 nM 10.1016/j.bmc.2008.10.065
Homo sapiens Serotonin transporter Ki 276.0 nM 10.1016/j.bmc.2009.01.023
Homo sapiens Serotonin transporter Ki 276.0 nM 10.1021/jm8010993
Homo sapiens Serotonin transporter Ki 297.0 nM 10.1016/j.bmcl.2003.07.014
Homo sapiens Serotonin transporter Ki 301.0 nM 10.1021/jm0001121
Homo sapiens Serotonin transporter Ki 310.0 nM 10.1021/jm000201d
Homo sapiens Serotonin transporter Ki 328.0 nM 10.1021/jm010302r
Homo sapiens Serotonin transporter Ki 340.0 nM 10.1021/jm0608614
Homo sapiens Serotonin transporter Ki 343.0 nM 10.1021/jm0001121
Homo sapiens Serotonin transporter Ki 358.0 nM 10.1021/jm050797a
Homo sapiens Serotonin transporter Ki 387.0 nM 10.1021/jm990161h
Homo sapiens Serotonin transporter Ki 390.0 nM 10.1021/jm9902178
Homo sapiens Serotonin transporter Ki 500.0 nM 10.1021/jm000201d
Homo sapiens Serotonin transporter Ki 524.0 nM 10.1016/j.bmc.2007.03.069
Homo sapiens Serotonin transporter Ki 525.0 nM 10.1016/j.bmc.2009.08.025
Homo sapiens Serotonin transporter Ki 601.0 nM 10.1016/s0960-894x(03)00386-x
Homo sapiens Serotonin transporter Ki 601.0 nM 10.1021/jm901189z
Homo sapiens Serotonin transporter Ki 632.0 nM 10.1021/acs.jmedchem.8b00542
Homo sapiens Serotonin transporter Ki 657.0 nM 10.1021/acs.jmedchem.7b00141
Homo sapiens Serotonin transporter Ki 818.0 nM 10.1016/j.bmcl.2013.03.066
Homo sapiens Serotonin transporter Ki 965.0 nM 10.1016/j.bmc.2007.03.069
Homo sapiens Serotonin transporter Ratio 0.07 None 10.1021/jm000201d
Homo sapiens Serotonin transporter Ratio 0.53 None 10.1016/s0960-894x(03)00386-x
Homo sapiens Serotonin transporter Ratio 0.62 None 10.1021/jm000201d
Homo sapiens Sigma opioid receptor Ki 8830.0 nM 10.1021/jm030008u
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) IC50 49000.0 nM 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 19.5 % 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 63.2 % 10.1021/jm00381a019
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Whole blood Retention_time 4.46 min 10.1007/s00044-012-9977-1
Macaca fascicularis Cynomolgus monkey Hill coefficient 0.54 nH 10.1021/jm00109a029
Macaca fascicularis Dopamine transporter IC50 95.6 nM 10.1016/s0960-894x(99)00098-0
Mus musculus Dopamine transporter IC50 200.0 nM 10.1021/acs.jmedchem.7b00141
Mus musculus Dopamine transporter Ki 850.0 nM 10.1021/acs.jmedchem.7b00141
Mus musculus GABA transporter 1 IC50 nan None 10.1021/jm0601654
Mus musculus Mus musculus Activity -21.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity -17.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity -10.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity -9.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 0.0 min 10.1021/jm901189z
Mus musculus Mus musculus Activity 10.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 14.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 16.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 16.7 m/3h 10.1016/j.bmcl.2005.08.028
Mus musculus Mus musculus Activity 24.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 27.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 91.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 100.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 127.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 194.0 s 10.1021/jm0601654
Mus musculus Mus musculus Activity 255.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 269.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 341.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity 391.0 % 10.1021/jm0401311
Mus musculus Mus musculus Activity nan None 10.1021/jm0401311
Mus musculus Mus musculus Amnesia reversal 10.0 % 10.1021/jm00371a023
Mus musculus Mus musculus Amnesia reversal 15.0 % 10.1021/jm00371a023
Mus musculus Mus musculus Change -53.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change -47.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change -26.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change -24.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change -7.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change -1.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change 5.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change 179.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change 201.0 % 10.1021/jm030453p
Mus musculus Mus musculus Change 452.0 % 10.1021/jm030453p
Mus musculus Mus musculus ED50 0.0 umol.kg-1 10.1021/jm00215a011
Mus musculus Mus musculus ED50 3.61 mg.kg-1 10.1021/jm000201d
Mus musculus Mus musculus ED50 7.8 mg.kg-1 10.1021/jm901189z
Mus musculus Mus musculus ED50 7.92 mg.kg-1 10.1021/jm000201d
Mus musculus Mus musculus ED50 10.0 mg.kg-1 10.1021/jm0401311
Mus musculus Mus musculus ED50 18.8 mg.kg-1 10.1021/jm030453p
Mus musculus Mus musculus ED50 20.79 umol.kg-1 10.1021/jm960739c
Mus musculus Mus musculus Horizontal activity 300.0 Counts min-1 10.1016/s0960-894x(01)00662-x
Mus musculus Mus musculus Horizontal activity 500.0 Counts min-1 10.1016/s0960-894x(01)00662-x
Mus musculus Mus musculus Horizontal activity 550.0 Counts min-1 10.1016/s0960-894x(01)00662-x
Mus musculus Mus musculus Horizontal activity 600.0 Counts min-1 10.1016/s0960-894x(01)00662-x
Mus musculus Mus musculus Max effect 12518.0 Counts 10min-1 10.1021/jm960739c
Mus musculus Mus musculus TIME 0.6667 hr 10.1021/jm901189z
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Dopamine transporter Activity nan None 10.1074/jbc.m610633200
Rattus norvegicus Dopamine transporter Control 43.0 % 10.1021/jm00088a017
Rattus norvegicus Dopamine transporter Control 74.1 % 10.1021/jm00040a019
Rattus norvegicus Dopamine transporter Control 79.0 % 10.1021/jm00088a017
Rattus norvegicus Dopamine transporter Control 85.0 % 10.1021/jm00088a017
Rattus norvegicus Dopamine transporter Control 97.0 % 10.1021/jm00088a017
Rattus norvegicus Dopamine transporter Control 137.9 % 10.1021/jm00040a019
Rattus norvegicus Dopamine transporter Discrimination ratio 2.5 None 10.1021/jm980566m
Rattus norvegicus Dopamine transporter Hill coefficient 0.87 None 10.1021/jm980028+
Rattus norvegicus Dopamine transporter Hill coefficient 1.03 None 10.1021/jm950697c
Rattus norvegicus Dopamine transporter Hill coefficient 1.06 None 10.1021/jm980028+
Rattus norvegicus Dopamine transporter IC50 66.0 nM 10.1021/jm00084a001
Rattus norvegicus Dopamine transporter IC50 67.8 nM 10.1021/jm00109a029
Rattus norvegicus Dopamine transporter IC50 70.0 nM 10.1021/jm00040a019
Rattus norvegicus Dopamine transporter IC50 82.0 nM 10.1021/jm00077a011
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1016/s0960-894x(01)00068-3
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1016/S0960-894X(97)10053-1
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1016/s0960-894x(98)00673-8
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1021/jm00002a020
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1021/jm00018a004
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1021/jm030092d
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1021/jm960409s
Rattus norvegicus Dopamine transporter IC50 89.0 nM 10.1021/jm960703k
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1016/s0960-894x(00)00480-7
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1021/jm00034a021
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1021/jm010302r
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1021/jm030453p
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1021/jm058164j
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1021/jm960515u
Rattus norvegicus Dopamine transporter IC50 89.1 nM 10.1021/jm970492z
Rattus norvegicus Dopamine transporter IC50 101.0 nM 10.1021/jm970025h
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm00075a012
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm00079a017
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm00079a018
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm00088a017
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm00091a019
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm00107a003
Rattus norvegicus Dopamine transporter IC50 102.0 nM 10.1021/jm980028+
Rattus norvegicus Dopamine transporter IC50 104.0 nM 10.1016/j.bmcl.2005.08.028
Rattus norvegicus Dopamine transporter IC50 107.0 nM 10.1021/jm00061a009
Rattus norvegicus Dopamine transporter IC50 139.0 nM 10.1021/jm00084a001
Rattus norvegicus Dopamine transporter IC50 150.0 nM 10.1021/jm00084a001
Rattus norvegicus Dopamine transporter IC50 150.0 nM 10.1021/jm0490235
Rattus norvegicus Dopamine transporter IC50 160.0 nM 10.1021/jm020410t
Rattus norvegicus Dopamine transporter IC50 160.0 nM 10.1021/jm980566m
Rattus norvegicus Dopamine transporter IC50 160.0 nM 10.1021/jm990306k
Rattus norvegicus Dopamine transporter IC50 173.0 nM 10.1021/jm950697c
Rattus norvegicus Dopamine transporter IC50 179.0 nM 10.1021/jm00077a011
Rattus norvegicus Dopamine transporter IC50 187.0 nM 10.1021/jm00061a009
Rattus norvegicus Dopamine transporter IC50 205.0 nM 10.1021/jm9902943
Rattus norvegicus Dopamine transporter IC50 209.0 nM 10.1021/jm970025h
Rattus norvegicus Dopamine transporter IC50 221.0 nM 10.1021/jm00114a027
Rattus norvegicus Dopamine transporter IC50 226.0 nM 10.1021/jm0601654
Rattus norvegicus Dopamine transporter IC50 236.0 nM 10.1021/jm0300375
Rattus norvegicus Dopamine transporter IC50 236.0 nM 10.1021/jm060762q
Rattus norvegicus Dopamine transporter IC50 239.0 nM 10.1021/jm980028+
Rattus norvegicus Dopamine transporter IC50 249.0 nM 10.1021/jm970121i
Rattus norvegicus Dopamine transporter IC50 249.0 nM 10.1021/jm980061w
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1016/s0960-894x(01)00443-7
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1016/s0960-894x(03)00169-0
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1021/jm000311k
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1021/jm010316x
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1021/jm020275k
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1021/jm020561w
Rattus norvegicus Dopamine transporter IC50 266.0 nM 10.1021/jm049796t
Rattus norvegicus Dopamine transporter IC50 296.0 nM 10.1021/jm00077a011
Rattus norvegicus Dopamine transporter IC50 297.0 nM 10.1016/s0960-894x(01)00132-9
Rattus norvegicus Dopamine transporter IC50 300.0 nM 10.1021/jm0601654
Rattus norvegicus Dopamine transporter IC50 338.0 nM 10.1021/jm010453u
Rattus norvegicus Dopamine transporter IC50 338.0 nM 10.1021/jm970549h
Rattus norvegicus Dopamine transporter IC50 341.0 nM 10.1021/jm960305h
Rattus norvegicus Dopamine transporter IC50 353.1 nM 10.1021/jm0490235
Rattus norvegicus Dopamine transporter IC50 400.0 nM 10.1021/jm9802564
Rattus norvegicus Dopamine transporter IC50 404.0 nM 10.1021/jm020410t
Rattus norvegicus Dopamine transporter IC50 404.0 nM 10.1021/jm950697c
Rattus norvegicus Dopamine transporter IC50 404.0 nM 10.1021/jm980566m
Rattus norvegicus Dopamine transporter IC50 404.0 nM 10.1021/jm990306k
Rattus norvegicus Dopamine transporter IC50 405.0 nM 10.1021/jm00049a004
Rattus norvegicus Dopamine transporter IC50 459.0 nM 10.1021/jm9802564
Rattus norvegicus Dopamine transporter IC50 478.0 nM 10.1021/jm960305h
Rattus norvegicus Dopamine transporter IC50 510.6 nM 10.1016/s0960-894x(01)00625-4
Rattus norvegicus Dopamine transporter IC50 580.0 nM 10.1021/jm00103a015
Rattus norvegicus Dopamine transporter IC50 660.0 nM 10.1021/jm960305h
Rattus norvegicus Dopamine transporter IC50 843.0 nM 10.1021/jm00084a001
Rattus norvegicus Dopamine transporter IC50 1450.0 nM 10.1021/jm00084a001
Rattus norvegicus Dopamine transporter IC50 1810.0 nM 10.1021/jm00084a001
Rattus norvegicus Dopamine transporter IC50 15800.0 nM 10.1021/jm00075a012
Rattus norvegicus Dopamine transporter IC50 15800.0 nM 10.1021/jm00107a003
Rattus norvegicus Dopamine transporter IC50 405000.0 nM 10.1021/jm0401614
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm00020a006
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm00049a004
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm010453u
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm960507d
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm960739c
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm9705061
Rattus norvegicus Dopamine transporter Ki 32.0 nM 10.1021/jm970549h
Rattus norvegicus Dopamine transporter Ki 71.8 nM 10.1021/jm060762q
Rattus norvegicus Dopamine transporter Ki 71.8 nM 10.1021/ml1002025
Rattus norvegicus Dopamine transporter Ki 74.3 nM 10.1016/j.bmcl.2004.03.075
Rattus norvegicus Dopamine transporter Ki 74.3 nM 10.1016/j.bmcl.2005.08.111
Rattus norvegicus Dopamine transporter Ki 89.0 nM 10.1016/j.bmcl.2004.12.014
Rattus norvegicus Dopamine transporter Ki 111.0 nM 10.1016/j.bmc.2007.03.035
Rattus norvegicus Dopamine transporter Ki 146.0 nM 10.1016/s0960-894x(01)00379-1
Rattus norvegicus Dopamine transporter Ki 187.0 nM 10.1016/s0960-894x(02)00464-x
Rattus norvegicus Dopamine transporter Ki 187.0 nM 10.1021/jm030008u
Rattus norvegicus Dopamine transporter Ki 187.0 nM 10.1021/jm9902943
Rattus norvegicus Dopamine transporter Ki 230.0 nM 10.1016/s0960-894x(00)00308-5
Rattus norvegicus Dopamine transporter Ki 230.0 nM 10.1016/s0960-894x(99)00607-1
Rattus norvegicus Dopamine transporter Ki 230.0 nM 10.1021/jm000141b
Rattus norvegicus Dopamine transporter Ki 230.0 nM 10.1021/jm000552s
Rattus norvegicus Dopamine transporter Ki 237.0 nM 10.1016/j.bmcl.2009.10.087
Rattus norvegicus Dopamine transporter Ki 241.3 nM 10.1021/jm00002a020
Rattus norvegicus Dopamine transporter Ki 259.0 nM 10.1016/s0960-894x(01)00379-1
Rattus norvegicus Dopamine transporter Ki 259.0 nM 10.1016/s0960-894x(02)00103-8
Rattus norvegicus Dopamine transporter Ki 259.0 nM 10.1021/jm0200153
Rattus norvegicus Dopamine transporter Ki 259.0 nM 10.1021/jm0303296
Rattus norvegicus Dopamine transporter Ki 270.0 nM 10.1016/s0960-894x(01)00132-9
Rattus norvegicus Dopamine transporter Ki 274.0 nM 10.1021/jm990516x
Rattus norvegicus Dopamine transporter Ki 280.0 nM 10.1016/s0960-894x(00)00269-9
Rattus norvegicus Dopamine transporter Ki 280.0 nM 10.1016/S0960-894X(01)80133-5
Rattus norvegicus Dopamine transporter Ki 280.0 nM 10.1016/s0960-894x(99)00273-5
Rattus norvegicus Dopamine transporter Ki 280.0 nM 10.1021/jm00046a029
Rattus norvegicus Dopamine transporter Ki 281.0 nM 10.1021/jm9802564
Rattus norvegicus Dopamine transporter Ki 285.0 nM 10.1021/jm0300375
Rattus norvegicus Dopamine transporter Ki 285.0 nM 10.1021/jm030646c
Rattus norvegicus Dopamine transporter Ki 301.0 nM 10.1016/s0960-894x(00)00308-5
Rattus norvegicus Dopamine transporter Ki 320.0 nM 10.1016/s0960-894x(99)00273-5
Rattus norvegicus Dopamine transporter Ki 350.0 nM 10.1021/jm9505324
Rattus norvegicus Dopamine transporter Ki 388.0 nM 10.1021/jm00041a002
Rattus norvegicus Dopamine transporter Ki 388.0 nM 10.1021/jm00049a004
Rattus norvegicus Dopamine transporter Ki 388.0 nM 10.1021/jm950782k
Rattus norvegicus Dopamine transporter Ki 388.0 nM 10.1021/jm960739c
Rattus norvegicus Dopamine transporter Ki 390.0 nM 10.1021/jm960507d
Rattus norvegicus Dopamine transporter Ki 390.0 nM 10.1021/jm9705061
Rattus norvegicus Dopamine transporter Ki 420.0 nM 10.1016/s0960-894x(00)00269-9
Rattus norvegicus Dopamine transporter Ki 420.0 nM 10.1016/s0960-894x(99)00607-1
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1016/s0960-894x(03)00786-8
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm0001121
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm000141b
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm000552s
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm0105373
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm020596w
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm040117o
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm9802564
Rattus norvegicus Dopamine transporter Ki 423.0 nM 10.1021/jm9905561
Rattus norvegicus Dopamine transporter Ki 460.0 nM 10.1016/s0960-894x(02)00348-7
Rattus norvegicus Dopamine transporter Ki 510.0 nM 10.1021/jm00037a004
Rattus norvegicus Dopamine transporter Ki 642.0 nM 10.1021/jm00036a020
Rattus norvegicus Dopamine transporter Ki 32000.0 nM 10.1021/jm0401614
Rattus norvegicus Dopamine transporter Ki 388000.0 nM 10.1021/jm0401614
Rattus norvegicus Dopamine transporter Ki 603000.0 nM 10.1021/jm00036a020
Rattus norvegicus Dopamine transporter Log potency ratio 0.0 None 10.1021/jm970025h
Rattus norvegicus Dopamine transporter Potency 0.65 % 10.1021/jm00107a003
Rattus norvegicus Dopamine transporter Potency 100.0 % 10.1021/jm00107a003
Rattus norvegicus Dopamine transporter Ratio 1.8 None 10.1021/jm00077a011
Rattus norvegicus Dopamine transporter Ratio 2.3 None 10.1021/jm950697c
Rattus norvegicus Dopamine transporter Ratio 4.7 None 10.1021/jm00077a011
Rattus norvegicus Dopamine transporter Ratio Ki 3.0 None 10.1016/j.bmc.2009.04.057
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate NMDA receptor Ki 10000.0 nM 10.1021/jm00077a011
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Monoamine transporters; Norepinephrine & serotonin Ratio 0.7 None 10.1016/s0960-894x(02)00103-8
Rattus norvegicus Monoamine transporters; Norepinephrine & serotonin Ratio 0.7 None 10.1021/jm0200153
Rattus norvegicus Monoamine transporters; Norepinephrine & serotonin Ratio 0.7 None 10.1021/jm020596w
Rattus norvegicus Monoamine transporters; Norepinephrine & serotonin Ratio 0.7 None 10.1021/jm0303296
Rattus norvegicus Monoamine transporters; Norepinephrine & serotonin Ratio 3.2 None 10.1016/j.bmcl.2004.12.014
Rattus norvegicus Monoamine transporters; Norepinephrine & serotonin Ratio 3.2 None 10.1021/jm960409s
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 0.26 None 10.1021/jm020596w
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 0.42 None 10.1016/s0960-894x(02)00103-8
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 0.42 None 10.1021/jm0200153
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 0.42 None 10.1021/jm0303296
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 0.69 None 10.1021/jm00002a020
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 37.0 None 10.1021/jm00002a020
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 37.0 None 10.1021/jm00034a021
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio 37.0 None 10.1021/jm970492z
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Ratio Ki 46.0 None 10.1021/jm060762q
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Selectivity 4.1 None 10.1021/jm980061w
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Selectivity 10.0 None 10.1021/jm980061w
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Selectivity 12.0 None 10.1021/jm030646c
Rattus norvegicus Monoamine transporters; Norepininephrine & dopamine Selectivity 86.0 None 10.1021/jm9505324
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.08 None 10.1016/j.bmcl.2004.12.014
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.09 None 10.1021/jm960409s
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.37 None 10.1021/jm020596w
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.46 None 10.1021/jm00002a020
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.6 None 10.1016/s0960-894x(02)00103-8
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.6 None 10.1021/jm0200153
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 0.6 None 10.1021/jm0303296
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 1.4 None 10.1016/s0960-894x(00)00308-5
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 2.7 None 10.1021/jm000311k
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 12.0 None 10.1021/jm00002a020
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 12.0 None 10.1021/jm00034a021
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio 12.0 None 10.1021/jm970492z
Rattus norvegicus Monoamine transporters; serotonin & dopamine Ratio Ki 4.0 None 10.1021/jm060762q
Rattus norvegicus Monoamine transporters; serotonin & dopamine Selectivity 1.0 None 10.1021/jm030646c
Rattus norvegicus Monoamine transporters; serotonin & dopamine Selectivity 29.0 None 10.1021/jm9505324
Rattus norvegicus Monoamine transporters; serotonin & dopamine Selectivity ratio 2.43 None 10.1021/jm020410t
Rattus norvegicus Monoamine transporters; serotonin & dopamine Uptake ratio 0.37 None 10.1021/jm9802564
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ki 61397.0 nM 10.1016/j.bmcl.2004.03.075
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ki 61400.0 nM 10.1021/jm030646c
Rattus norvegicus Muscarinic acetylcholine receptor M1 Ki 61400.0 nM 10.1021/jm060762q
Rattus norvegicus Norepinephrine transporter IC50 2500.0 nM 10.1021/jm980061w
Rattus norvegicus Norepinephrine transporter IC50 3298.0 nM 10.1021/jm00002a020
Rattus norvegicus Norepinephrine transporter IC50 3298.0 nM 10.1021/jm00018a004
Rattus norvegicus Norepinephrine transporter IC50 3298.0 nM 10.1021/jm00034a021
Rattus norvegicus Norepinephrine transporter IC50 3298.0 nM 10.1021/jm960409s
Rattus norvegicus Norepinephrine transporter IC50 3298.0 nM 10.1021/jm960515u
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1016/s0960-894x(00)00480-7
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1016/S0960-894X(97)10053-1
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1016/s0960-894x(98)00673-8
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1021/jm030092d
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1021/jm030453p
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1021/jm058164j
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1021/jm960703k
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1021/jm970492z
Rattus norvegicus Norepinephrine transporter IC50 3300.0 nM 10.1021/jm990306k
Rattus norvegicus Norepinephrine transporter IC50 3520.0 nM 10.1016/s0960-894x(01)00443-7
Rattus norvegicus Norepinephrine transporter IC50 3530.0 nM 10.1016/s0960-894x(03)00169-0
Rattus norvegicus Norepinephrine transporter IC50 3530.0 nM 10.1021/jm000311k
Rattus norvegicus Norepinephrine transporter IC50 3530.0 nM 10.1021/jm010316x
Rattus norvegicus Norepinephrine transporter IC50 3530.0 nM 10.1021/jm020275k
Rattus norvegicus Norepinephrine transporter IC50 3530.0 nM 10.1021/jm020561w
Rattus norvegicus Norepinephrine transporter IC50 3530.0 nM 10.1021/jm049796t
Rattus norvegicus Norepinephrine transporter IC50 3825.0 nM 10.1021/jm00091a019
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1016/s0960-894x(00)00269-9
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1016/s0960-894x(01)00379-1
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1016/s0960-894x(02)00103-8
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1016/s0960-894x(03)00786-8
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm0001121
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm000552s
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm0105373
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm0200153
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm020596w
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm0303296
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm040117o
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm990516x
Rattus norvegicus Norepinephrine transporter Ki 108.0 nM 10.1021/jm9905561
Rattus norvegicus Norepinephrine transporter Ki 160.55 nM 10.1021/jm00002a020
Rattus norvegicus Norepinephrine transporter Ki 186.0 nM 10.1016/s0960-894x(00)00308-5
Rattus norvegicus Norepinephrine transporter Ki 190.0 nM 10.1016/s0960-894x(01)00132-9
Rattus norvegicus Norepinephrine transporter Ki 1900.0 nM 10.1016/s0960-894x(00)00480-7
Rattus norvegicus Norepinephrine transporter Ki 1900.0 nM 10.1021/jm058164j
Rattus norvegicus Norepinephrine transporter Ki 1990.0 nM 10.1021/jm030453p
Rattus norvegicus Norepinephrine transporter Ki 2000.0 nM 10.1021/jm030092d
Rattus norvegicus Norepinephrine transporter Ki 3300.0 nM 10.1021/jm030646c
Rattus norvegicus Norepinephrine transporter Ki 3300.0 nM 10.1021/jm060762q
Rattus norvegicus Norepinephrine transporter Ki 3300.0 nM 10.1021/jm9902943
Rattus norvegicus Norepinephrine transporter Ki 3302.0 nM 10.1016/j.bmcl.2004.03.075
Rattus norvegicus Norepinephrine transporter Ki 3320.0 nM 10.1016/j.bmcl.2004.12.014
Rattus norvegicus Norepinephrine transporter Ki 30000.0 nM 10.1021/jm9505324
Rattus norvegicus Norepinephrine transporter Ratio 38.0 None 10.1021/jm00091a019
Rattus norvegicus Rattus norvegicus Activity 21.0 % 10.1021/jm0401311
Rattus norvegicus Rattus norvegicus Activity 32.0 % 10.1021/jm0401311
Rattus norvegicus Rattus norvegicus Activity 59.0 % 10.1021/jm0401311
Rattus norvegicus Rattus norvegicus Activity 82.0 % 10.1021/jm0401311
Rattus norvegicus Rattus norvegicus Activity 97.0 % 10.1021/jm0401311
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00210a014
Rattus norvegicus Rattus norvegicus Change -30.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Change -27.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Change -17.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Change -16.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Change 22.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Change 43.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Cocaine 100.0 % 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Count/h 712.0 None 10.1021/jm00037a004
Rattus norvegicus Rattus norvegicus Count/h 1960.0 None 10.1021/jm00037a004
Rattus norvegicus Rattus norvegicus Count/h 14940.0 None 10.1021/jm00037a004
Rattus norvegicus Rattus norvegicus Count/h 15710.0 None 10.1021/jm00037a004
Rattus norvegicus Rattus norvegicus Drug discrimination effect 21.0 % 10.1021/jm030453p
Rattus norvegicus Rattus norvegicus Drug discrimination effect 32.0 % 10.1021/jm030453p
Rattus norvegicus Rattus norvegicus Drug discrimination effect 59.0 % 10.1021/jm030453p
Rattus norvegicus Rattus norvegicus Drug discrimination effect 82.0 % 10.1021/jm030453p
Rattus norvegicus Rattus norvegicus Drug discrimination effect 97.0 % 10.1021/jm030453p
Rattus norvegicus Rattus norvegicus Drug response 6.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 31.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 44.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 61.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 81.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 85.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 98.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 99.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Drug response 100.0 % 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus ED50 1.47 mg.kg-1 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Rattus norvegicus ED50 1.5 mg.kg-1 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Rattus norvegicus ED50 1.7 mg.kg-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus ED50 2.44 mg.kg-1 10.1021/jm0401311
Rattus norvegicus Rattus norvegicus ED50 2.5 mg.kg-1 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus ED50 2.64 mg.kg-1 10.1021/jm030453p
Rattus norvegicus Rattus norvegicus ED50 3.68 mg.kg-1 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Rattus norvegicus ED50 5.63 mg.kg-1 10.1021/acs.jmedchem.7b00085
Rattus norvegicus Rattus norvegicus ED50 5.9 mg.kg-1 10.1021/jm901189z
Rattus norvegicus Rattus norvegicus ED50 8.74 umol.kg-1 10.1021/jm960739c
Rattus norvegicus Rattus norvegicus ED50 10.0 mg.kg-1 10.1021/jm00125a020
Rattus norvegicus Rattus norvegicus ED50 21.0 mg.kg-1 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus IC50 127.0 nM 10.1021/jm9905561
Rattus norvegicus Rattus norvegicus IC50 138.0 nM 10.1021/jm00061a009
Rattus norvegicus Rattus norvegicus IC50 168.0 nM 10.1021/jm9905561
Rattus norvegicus Rattus norvegicus IC50 191.0 nM 10.1016/s0960-894x(01)00443-7
Rattus norvegicus Rattus norvegicus IC50 208.0 nM 10.1016/s0960-894x(01)00068-3
Rattus norvegicus Rattus norvegicus IC50 210.0 nM 10.1021/jm00040a019
Rattus norvegicus Rattus norvegicus IC50 213.0 nM 10.1021/jm00106a035
Rattus norvegicus Rattus norvegicus IC50 236.0 nM 10.1021/jm030646c
Rattus norvegicus Rattus norvegicus IC50 297.0 nM 10.1016/s0960-894x(00)00703-4
Rattus norvegicus Rattus norvegicus IC50 336.0 nM 10.1021/jm00076a028
Rattus norvegicus Rattus norvegicus IC50 405.0 nM 10.1021/jm010453u
Rattus norvegicus Rattus norvegicus IC50 405.0 nM 10.1021/jm960739c
Rattus norvegicus Rattus norvegicus IC50 405.0 nM 10.1021/jm970549h
Rattus norvegicus Rattus norvegicus IC50 459.0 nM 10.1021/jm9905561
Rattus norvegicus Rattus norvegicus IC50 490.0 nM 10.1016/s0960-894x(00)00703-4
Rattus norvegicus Rattus norvegicus IC50 538.0 nM 10.1016/s0960-894x(00)00703-4
Rattus norvegicus Rattus norvegicus IC50 570.0 nM 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus IC50 686.0 nM 10.1016/s0960-894x(00)00703-4
Rattus norvegicus Rattus norvegicus IC50 696.0 nM 10.1016/s0960-894x(00)00703-4
Rattus norvegicus Rattus norvegicus IC50 123254.0 nM 10.1021/jm00041a002
Rattus norvegicus Rattus norvegicus Ki 108.0 nM 10.1021/jm000141b
Rattus norvegicus Rattus norvegicus Ki 155.0 nM 10.1021/jm000141b
Rattus norvegicus Rattus norvegicus Ki 280.0 nM 10.1021/jm00076a028
Rattus norvegicus Rattus norvegicus Ki 320.0 nM 10.1016/S0960-894X(01)80133-5
Rattus norvegicus Rattus norvegicus Ki 320.0 nM 10.1021/jm00046a029
Rattus norvegicus Rattus norvegicus Ki 320.0 nM 10.1021/jm00076a028
Rattus norvegicus Rattus norvegicus n/N 7.0 / 7 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus No. resp animals / Total 7.0 / 7 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Peak time 0.0 min 10.1021/jm030092d
Rattus norvegicus Rattus norvegicus Rate response 21.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 23.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 27.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 28.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 32.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 61.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 76.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus Rate response 89.0 min-1 10.1021/jm00103a015
Rattus norvegicus Rattus norvegicus TIME 2.0 hr 10.1021/jm030092d
Rattus norvegicus Serotonin transporter IC50 0.5 nM 10.1021/jm0490235
Rattus norvegicus Serotonin transporter IC50 168.0 nM 10.1021/jm9802564
Rattus norvegicus Serotonin transporter IC50 207.0 nM 10.1021/jm00114a027
Rattus norvegicus Serotonin transporter IC50 304.0 nM 10.1021/jm960305h
Rattus norvegicus Serotonin transporter IC50 389.0 nM 10.1021/jm020410t
Rattus norvegicus Serotonin transporter IC50 400.0 nM 10.1021/jm0601654
Rattus norvegicus Serotonin transporter IC50 615.0 nM 10.1021/jm980061w
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1016/s0960-894x(01)00443-7
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1016/s0960-894x(03)00169-0
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1021/jm000311k
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1021/jm010316x
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1021/jm020275k
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1021/jm020561w
Rattus norvegicus Serotonin transporter IC50 737.0 nM 10.1021/jm049796t
Rattus norvegicus Serotonin transporter IC50 1045.0 nM 10.1016/S0960-894X(97)10053-1
Rattus norvegicus Serotonin transporter IC50 1045.0 nM 10.1021/jm00002a020
Rattus norvegicus Serotonin transporter IC50 1045.0 nM 10.1021/jm00018a004
Rattus norvegicus Serotonin transporter IC50 1045.0 nM 10.1021/jm00034a021
Rattus norvegicus Serotonin transporter IC50 1045.0 nM 10.1021/jm960409s
Rattus norvegicus Serotonin transporter IC50 1045.0 nM 10.1021/jm960515u
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1016/s0960-894x(00)00480-7
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1016/s0960-894x(98)00673-8
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1021/jm030092d
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1021/jm030453p
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1021/jm058164j
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1021/jm960703k
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1021/jm970492z
Rattus norvegicus Serotonin transporter IC50 1050.0 nM 10.1021/jm990306k
Rattus norvegicus Serotonin transporter IC50 1059.0 nM 10.1021/jm00091a019
Rattus norvegicus Serotonin transporter Ki 45.0 nM 10.1021/jm030453p
Rattus norvegicus Serotonin transporter Ki 95.0 nM 10.1016/s0960-894x(00)00480-7
Rattus norvegicus Serotonin transporter Ki 95.0 nM 10.1021/jm058164j
Rattus norvegicus Serotonin transporter Ki 96.0 nM 10.1021/jm030092d
Rattus norvegicus Serotonin transporter Ki 112.11 nM 10.1021/jm00002a020
Rattus norvegicus Serotonin transporter Ki 130.0 nM 10.1016/s0960-894x(02)00348-7
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1016/s0960-894x(01)00379-1
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1016/s0960-894x(02)00103-8
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1016/s0960-894x(03)00786-8
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm0001121
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm000552s
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm0105373
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm0200153
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm020596w
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm0303296
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm040117o
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm9802564
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm990516x
Rattus norvegicus Serotonin transporter Ki 155.0 nM 10.1021/jm9905561
Rattus norvegicus Serotonin transporter Ki 160.0 nM 10.1016/s0960-894x(00)00269-9
Rattus norvegicus Serotonin transporter Ki 160.0 nM 10.1016/s0960-894x(01)00132-9
Rattus norvegicus Serotonin transporter Ki 160.0 nM 10.1016/s0960-894x(99)00607-1
Rattus norvegicus Serotonin transporter Ki 172.0 nM 10.1021/jm9902943
Rattus norvegicus Serotonin transporter Ki 286.0 nM 10.1016/j.bmcl.2009.10.087
Rattus norvegicus Serotonin transporter Ki 286.0 nM 10.1021/jm030646c
Rattus norvegicus Serotonin transporter Ki 286.0 nM 10.1021/jm060762q
Rattus norvegicus Serotonin transporter Ki 286.0 nM 10.1021/ml1002025
Rattus norvegicus Serotonin transporter Ki 293.0 nM 10.1016/j.bmcl.2004.03.075
Rattus norvegicus Serotonin transporter Ki 413.0 nM 10.1016/s0960-894x(00)00308-5
Rattus norvegicus Serotonin transporter Ki 1050.0 nM 10.1016/j.bmcl.2004.12.014
Rattus norvegicus Serotonin transporter Ki 10000.0 nM 10.1021/jm9505324
Rattus norvegicus Serotonin transporter Km 200.0 nM 10.1074/jbc.m704456200
Rattus norvegicus Serotonin transporter Ratio 10.0 None 10.1021/jm00091a019
Rattus norvegicus Serotonin transporter Vmax 35.7 pmol/min/mg 10.1074/jbc.m704456200
Rattus norvegicus Solute carrier family 22 member 2 Activity nan None 10.1074/jbc.273.47.30915
Rattus norvegicus Transporter Ki 3192.0 nM 10.1016/j.bmcl.2009.10.087
Rattus norvegicus Transporter Ki 3300.0 nM 10.1021/ml1002025
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
None ADMET Activity 8000.0 cm 10.1016/j.ejmech.2020.112674
None ADMET Activity nan None 10.1021/acs.jmedchem.9b01188
None ADMET CL 32.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 32.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 64.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 102.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET CL 260.0 mL.min-1.kg-1 10.1002/jps.20373
None ADMET eLog D 0.48 None 10.1021/jm0200409
None ADMET Fraction ionised 0.952 None 10.1021/jm0200409
None ADMET Free fraction 10.0 % 10.1021/jm00090a005
None ADMET Fu 0.018 None 10.1021/jm0200409
None ADMET Fu 0.09 None 10.1021/jm0200409
None ADMET Fu 0.09 None 10.1021/jm030408h
None ADMET logP(lung) 1.06 None 10.1016/j.ejmech.2007.04.002
None ADMET MRT 1.0 hr 10.1124/dmd.108.020479
None ADMET Plasma integral 2.1 uCi min ml-1 10.1021/jm00090a005
None ADMET T1/2 0.3333 hr 10.1021/acs.jmedchem.6b01827
None ADMET T1/2 0.76 hr 10.1124/dmd.108.020479
None ADMET Tracer 0.4 % 10.1021/jm00090a005
None ADMET Tracer 6.0 % 10.1021/jm00090a005
None ADMET Tracer 11.0 % 10.1021/jm00090a005
None ADMET Tracer 12.0 % 10.1021/jm00090a005
None ADMET Tracer 13.0 % 10.1021/jm00090a005
None ADMET Tracer 17.0 % 10.1021/jm00090a005
None ADMET Tracer 22.0 % 10.1021/jm00090a005
None ADMET Tracer 30.0 % 10.1021/jm00090a005
None ADMET Tracer 31.0 % 10.1021/jm00090a005
None ADMET Tracer 37.0 % 10.1021/jm00090a005
None ADMET Tracer 38.0 % 10.1021/jm00090a005
None ADMET Tracer 44.0 % 10.1021/jm00090a005
None ADMET Tracer 60.0 % 10.1021/jm00090a005
None ADMET Tracer 70.0 % 10.1021/jm00090a005
None ADMET Unmetabolized 17.0 % 10.1021/jm00090a005
None ADMET Vdss 2.0 L.kg-1 10.1002/jps.20373
None ADMET Vdss 2.0 L.kg-1 10.1021/jm0200409
None ADMET Vdss 2.0 L.kg-1 10.1021/jm030408h
None ADMET Vdss 2.0 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 3.8 L.kg-1 10.1002/jps.20373
None ADMET Vdss 7.4 L.kg-1 10.1002/jps.20373
None ADMET Vdss 16.0 mL/min/kg 10.1002/jps.20373
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None NON-PROTEIN TARGET Activity nan None 10.1021/acs.jmedchem.6b01373
None NON-PROTEIN TARGET Fu 0.12 None 10.1124/dmd.108.020479
None No relevant target CLogD 1.51 None 10.1021/jm030008u
None No relevant target CLogP 2.57 None 10.1021/jm0303296
None No relevant target CLogP 2.57 None 10.1021/jm049796t
None No relevant target LogD 0.41 None 10.1016/j.ejmech.2008.11.009
None No relevant target LogD 1.05 None 10.1021/jm0100990
None No relevant target LogD 1.51 None 10.1021/jm030646c
None No relevant target LogP 1.82 None 10.1016/j.bmc.2008.10.031
None No relevant target LogP 2.3 None 10.1021/jm070524a
None No relevant target LogP 2.57 None 10.1016/j.bmc.2008.11.008
None No relevant target Log S -2.25 None 10.1016/s0960-894x(00)00172-4
None No relevant target logS0 -2.25 None 10.1021/jm701587d
None No relevant target pKa 8.7 None 10.1007/s11095-013-1232-z
None No relevant target pKa 8.7 None 10.1021/jm0200409
None No relevant target pKa 8.7 None 10.1021/jm030408h
None No relevant target pKa 8.7 None 10.1021/jm070524a
None Unchecked Activity 0.58 uM 10.1074/jbc.m704456200
None Unchecked Activity 130.0 % 10.1016/j.bmcl.2014.04.040
None Unchecked Binding constant 60.0 M-1 10.1016/s0960-894x(00)00371-1
None Unchecked Binding constant 570.0 M-1 10.1016/s0960-894x(00)00371-1
None Unchecked Hill coefficient 0.91 None 10.1021/jm00107a003
None Unchecked Hill coefficient 0.96 None 10.1021/jm00107a003
None Unchecked IC50 89.1 nM 10.1021/jm040185a
None Unchecked IC50 100.0 nM 10.1016/j.bmcl.2004.09.080
None Unchecked IC50 575.0 nM 10.1021/jm00193a018
None Unchecked IC50 48977.88 nM 10.1016/j.bmc.2008.10.031
None Unchecked IC50 49000.0 nM 10.1016/j.bmc.2008.10.031
None Unchecked Inhibition nan % 10.1016/j.bmcl.2014.04.040
None Unchecked Kd 1750000.0 nM 10.1016/s0960-894x(00)00371-1
None Unchecked Ki 230.0 nM 10.1016/s0960-894x(01)00132-9
None Unchecked Ki 321.0 nM 10.1021/acs.jmedchem.6b01373
None Unchecked Ki 350.0 nM 10.1021/acs.jmedchem.9b01188
None Unchecked Ki 1050.0 nM 10.1021/jm040185a
None Unchecked Ki 3300.0 nM 10.1021/jm040185a
None Unchecked Ki 16218.1 nM 10.1016/j.bmcl.2009.03.164
None Unchecked logIC50 1.69 None 10.1016/j.bmc.2013.11.049
None Unchecked pD2 6.52 None 10.1016/j.bmcl.2014.04.040
None Unchecked Ratio 0.1 None 10.1021/jm010302r
None Unchecked Ratio 0.26 None 10.1016/s0960-894x(03)00786-8
None Unchecked Ratio 0.26 None 10.1021/jm0105373
None Unchecked Ratio 0.37 None 10.1016/s0960-894x(03)00786-8
None Unchecked Ratio 0.6 None 10.1021/jm010302r
None Unchecked Ratio 0.7 None 10.1016/s0960-894x(03)00786-8
None Unchecked Ratio 0.7 None 10.1021/jm0105373
None Unchecked Ratio 0.77 None 10.1021/jm00061a009
None Unchecked Ratio 0.83 None 10.1016/j.bmcl.2009.10.087
None Unchecked Ratio 1.0 None 10.1021/jm010302r
None Unchecked Ratio 2.7 None 10.1021/jm0105373
None Unchecked Ratio 11.0 None 10.1016/j.bmcl.2009.10.087
None Unchecked Ratio 12.0 None 10.1016/j.bmcl.2009.10.087
None Unchecked Ratio 21.0 None 10.1021/jm990306k
None Unchecked Ratio 22.0 None 10.1016/j.bmc.2009.05.052
None Unchecked Ratio 47.0 None 10.1021/jm030008u
None Unchecked Ratio Ki 0.8 None 10.1021/acs.jmedchem.9b01188
None Unchecked Ratio Ki 1.4 None 10.1021/acs.jmedchem.6b01373
None Unchecked Ratio Ki 21.0 None 10.1016/j.bmc.2009.05.052
None Unchecked Ratio Ki 853.0 None 10.1021/jm060762q
None Unchecked Selectivity 0.2 None 10.1016/s0960-894x(01)00379-1
None Unchecked Selectivity 0.37 None 10.1016/s0960-894x(01)00379-1
None Unchecked Selectivity 0.38 None 10.1016/s0960-894x(99)00607-1
None Unchecked Selectivity 0.7 None 10.1016/s0960-894x(01)00379-1
None Unchecked Selectivity 2.0 None 10.1016/S0960-894X(97)10053-1
None Unchecked Selectivity 215.0 None 10.1021/jm030646c
None Unchecked Selectivity nan None 10.1016/S0960-894X(97)10053-1
None Unchecked Selectivity nan None 10.1021/jm020275k
None Unchecked Selectivity ratio 3.0 None 10.1021/jm00059a010

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT009693 CCO.COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C>>CCOC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C RXN-13425
AKRT009694 CCO.COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C>>CCOC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C enzymemap_53477
AKRT009726 CCOC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C.CO>>COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C RXN-13425
AKRT011081 COC(=O)[C@@H]1C2CCC(C[C@@H]1O)N2C.O=C([CoA])c1ccccc1>>COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C R08430
AKRT011088 COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C>>CN1[C@@H]2CC[C@H]1C[C@H](OC(=O)c1ccccc1)[C@@H]2C(=O)O.CO None
AKRT011089 COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C>>COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1O)N2C RXN-11192
AKRT011090 COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C>>COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1O)N2C.O=C(O)c1ccccc1 None
AKRT011138 COC(=O)[C@H]1[C@@H](O)C[C@@H]2CC[C@H]1N2C.O=C([CoA])c1ccccc1>>COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C RXN-9201
AKRT011140 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C>>CN1[C@H]2CC[C@@H]1[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C2 RXN-13424
AKRT011141 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C>>CO enzymemap_51064
AKRT011142 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C>>COC(=O)[C@@H]1C2CCC(C[C@@H]1O)N2C R06728
AKRT011143 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C>>COC(=O)[C@H]1[C@@H](O)C[C@@H]2CC[C@H]1N2C enzymemap_51304
AKRT011144 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C>>O=C(O)c1ccccc1 R06728