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Eudistomin Y1

AlkaPlorer ID: AK005025

Synonym: None

IUPAC Name: (4-hydroxyphenyl)-(9H-pyrido[3,4-b]indol-1-yl)methanone

Structure

SMILES: C1=CC=C2C(=C1)C3=C(N2)C(=NC=C3)C(=O)C4=CC=C(C=C4)O

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InChI: InChI=1S/C18H12N2O2/c21-12-7-5-11(6-8-12)18(22)17-16-14(9-10-19-17)13-3-1-2-4-15(13)20-16/h1-10,20-21H

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InChIKey: DISBVDLVVUJENS-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 288.306

TPSA？: 65.98

MolLogP？: 3.6527000000000016

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Bacillus subtilis Bacillus subtilis MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Candida albicans MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Candida albicans Isocitrate lyase IC50 48200.0 nM 10.1016/j.bmc.2012.05.002
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Homo sapiens A549 LC50 59000.0 nM 10.1016/j.bmc.2012.05.002
Micrococcus luteus Micrococcus luteus MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Proteus vulgaris Proteus vulgaris MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Sortase A IC50 346900.0 nM 10.1016/j.bmc.2012.05.002
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Staphylococcus epidermidis Staphylococcus epidermidis MIC 50.0 ug.mL-1 10.1021/np070064o
Trichophyton mentagrophytes Trichophyton mentagrophytes MIC 100.0 ug.mL-1 10.1016/j.bmc.2012.05.002
Trichophyton rubrum Trichophyton rubrum MIC 50.0 ug.mL-1 10.1016/j.bmc.2012.05.002
None Unchecked IC50 346900.0 nM 10.1016/j.bmc.2012.05.002

Metabolism Information