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Framycetin

AlkaPlorer ID: AK005109

Synonym: 'Framycetin', 'Neomycin'

IUPAC Name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol

Structure

SMILES: NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O

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InChI: InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

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InChIKey: PGBHMTALBVVCIT-VCIWKGPPSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Streptomyces rimosus Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 614.6500000000003

TPSA？: 353.11

MolLogP？: -8.895300000000017

Number of H-Donors: 13

Number of H-Acceptors: 19

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1021/jm1000437
Acinetobacter lwoffii Acinetobacter lwoffii Activity 8.0 ug ml-1 10.1128/aac.00652-07
Acinetobacter lwoffii Acinetobacter lwoffii MIC 0.25 ug.mL-1 10.1016/j.ejmech.2018.08.022
Acinetobacter lwoffii Acinetobacter lwoffii MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.6b00818
Acinetobacter lwoffii Acinetobacter lwoffii MIC 0.5 ug.mL-1 10.1021/jm401148j
Acinetobacter lwoffii Acinetobacter lwoffii MIC 0.5 ug.mL-1 10.1021/jm900615h
Acinetobacter lwoffii Acinetobacter lwoffii MIC 64.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Acinetobacter lwoffii Acinetobacter lwoffii MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Acinetobacter lwoffii Acinetobacter lwoffii MIC 128.0 ug.mL-1 10.1021/jm401148j
Acinetobacter lwoffii Acinetobacter lwoffii MIC 128.0 ug.mL-1 10.1021/jm900615h
Actinomyces viscosus Actinomyces viscosus MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Actinomyces viscosus Actinomyces viscosus MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Actinomyces viscosus Actinomyces viscosus MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus prevotii Anaerococcus prevotii MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus prevotii Anaerococcus prevotii MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus prevotii Anaerococcus prevotii MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus tetradius Anaerococcus tetradius MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus tetradius Anaerococcus tetradius MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Anaerococcus tetradius Anaerococcus tetradius MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Bacillus anthracis Anthrax lethal factor Ki 7.0 nM 10.1016/j.ejmech.2021.113877
Bacillus anthracis Anthrax lethal factor Ki 500.0 nM 10.1016/j.bmcl.2006.07.005
Bacillus anthracis Bacillus anthracis MIC 1560.0 nM 10.1016/j.ejmech.2018.11.022
Bacillus subtilis Bacillus subtilis IZ 26.12 mm 10.1007/s00044-013-0755-5
Bacillus subtilis Bacillus subtilis Kd 8500.0 nM 10.1016/j.bmcl.2005.02.007
Bacillus subtilis Bacillus subtilis MIC 0.78 ug.mL-1 10.1007/s00044-010-9490-3
Bacillus subtilis Bacillus subtilis MIC 1.5 ug.mL-1 10.1021/jm900028n
Bacillus subtilis Bacillus subtilis MIC 12.5 ug.mL-1 10.1016/j.bmcl.2014.08.064
Bacillus subtilis Bacillus subtilis MIC 18.75 ug.mL-1 10.1007/s00044-012-0450-y
Bacteria Bacterial 70S ribosome IC50 32.0 nM 10.1016/j.bmcl.2010.10.001
Bacteroides caccae Bacteroides caccae MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides caccae Bacteroides caccae MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides fragilis Bacteroides fragilis MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides fragilis Bacteroides fragilis MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides ovatus Bacteroides ovatus MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides ovatus Bacteroides ovatus MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides stercoris Bacteroides stercoris MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides stercoris Bacteroides stercoris MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides uniformis Bacteroides uniformis MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Bacteroides uniformis Bacteroides uniformis MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium bifidum Bifidobacterium bifidum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium bifidum Bifidobacterium bifidum MIC 62.5 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium bifidum Bifidobacterium bifidum MIC 125.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium bifidum Bifidobacterium bifidum MIC 250.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium bifidum Bifidobacterium bifidum MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium bifidum Bifidobacterium bifidum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium breve Bifidobacterium breve MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium breve Bifidobacterium breve MIC 62.5 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium breve Bifidobacterium breve MIC 125.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium breve Bifidobacterium breve MIC 250.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium breve Bifidobacterium breve MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium breve Bifidobacterium breve MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium longum Bifidobacterium longum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium longum Bifidobacterium longum MIC 62.5 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium longum Bifidobacterium longum MIC 125.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium longum Bifidobacterium longum MIC 250.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium longum Bifidobacterium longum MIC 500.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium longum Bifidobacterium longum MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium longum Bifidobacterium longum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Bifidobacterium thermophilum Bifidobacterium thermophilum MIC 125.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium thermophilum Bifidobacterium thermophilum MIC 250.0 ug.mL-1 10.1128/aac.00261-06
Bifidobacterium thermophilum Bifidobacterium thermophilum MIC 500.0 ug.mL-1 10.1128/aac.00261-06
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans MIC 512.0 ug.mL-1 10.1021/jm800345u
Cavia porcellus Cavia porcellus Activity 0.0 % 10.1016/j.bmc.2007.03.056
Cavia porcellus Cavia porcellus Activity 50.0 % 10.1016/j.bmc.2007.03.056
Cavia porcellus Cavia porcellus Activity 100.0 % 10.1016/j.bmc.2007.03.056
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Clostridioides difficile Clostridioides difficile MIC 128.0 ug.mL-1 10.1128/aac.00441-08
Clostridioides difficile Clostridioides difficile MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridioides difficile Clostridioides difficile MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Clostridium acetobutylicum Clostridium acetobutylicum MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium acetobutylicum Clostridium acetobutylicum MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium acetobutylicum Clostridium acetobutylicum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium beijerinckii Clostridium beijerinckii MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium beijerinckii Clostridium beijerinckii MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium beijerinckii Clostridium beijerinckii MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium butyricum Clostridium butyricum MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium butyricum Clostridium butyricum MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium butyricum Clostridium butyricum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium cadaveris Clostridium cadaveris MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium cadaveris Clostridium cadaveris MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium cadaveris Clostridium cadaveris MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
[Clostridium] innocuum [Clostridium] innocuum MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
[Clostridium] innocuum [Clostridium] innocuum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium paraputrificum Clostridium paraputrificum MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium paraputrificum Clostridium paraputrificum MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium paraputrificum Clostridium paraputrificum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium perfringens Clostridium perfringens MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium perfringens Clostridium perfringens MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium septicum Clostridium septicum MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium septicum Clostridium septicum MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium septicum Clostridium septicum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium sporogenes Clostridium sporogenes MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium sporogenes Clostridium sporogenes MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium sporogenes Clostridium sporogenes MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Clostridium tertium Clostridium tertium MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Clostridium tertium Clostridium tertium MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Clostridium tertium Clostridium tertium MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Collinsella aerofaciens Collinsella aerofaciens MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Collinsella aerofaciens Collinsella aerofaciens MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Collinsella aerofaciens Collinsella aerofaciens MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Cutibacterium acnes Cutibacterium acnes MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Cutibacterium acnes Cutibacterium acnes MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Cutibacterium acnes Cutibacterium acnes MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Eggerthella lenta Eggerthella lenta MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Eggerthella lenta Eggerthella lenta MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Eggerthella lenta Eggerthella lenta MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Elizabethkingia meningoseptica Elizabethkingia meningoseptica MIC 12.5 ug.mL-1 10.1007/s00044-010-9490-3
Enterocloster clostridioformis Enterocloster clostridioformis MIC 32.0 ug.mL-1 10.1128/aac.00441-08
Enterocloster clostridioformis Enterocloster clostridioformis MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Enterocloster clostridioformis Enterocloster clostridioformis MIC90 128.0 ug.mL-1 10.1128/aac.00441-08
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Enterococcus faecalis Enterococcus faecalis MIC 64.0 ug.mL-1 10.1021/jm800997s
Enterococcus faecalis Enterococcus faecalis MIC 125.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Enterococcus faecalis Enterococcus faecalis MIC 250.0 ug.mL-1 10.1021/jm800997s
Enterococcus faecalis Enterococcus faecalis MIC 250.0 ug.mL-1 10.1039/c4md00078a
Enterococcus faecium Enterococcus faecium MIC99 16.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Enterococcus faecium Enterococcus faecium MIC99 128.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmc.2007.03.056
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.8b01357
Escherichia coli Escherichia coli IC50 10500.0 nM 10.1021/jm900028n
Escherichia coli Escherichia coli IZ 12.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 15.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 18.0 mm 10.1021/jm060492b
Escherichia coli Escherichia coli IZ 26.12 mm 10.1007/s00044-013-0755-5
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.01345-06
Escherichia coli Escherichia coli MIC 0.13 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00795-06
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jm401148j
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.08.018
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/jm401148j
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/jm900615h
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01360-08
Escherichia coli Escherichia coli MIC 3.0 ug.mL-1 10.1016/j.bmcl.2010.09.084
Escherichia coli Escherichia coli MIC 3.13 ug.mL-1 10.1007/s00044-010-9490-3
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmc.2007.08.059
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.01.027
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm1000437
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm401148j
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm800345u
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm800997s
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1021/jm900615h
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1039/c4md00078a
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01360-08
Escherichia coli Escherichia coli MIC 6.0 ug.mL-1 10.1021/jm900028n
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm1000437
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm800345u
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1021/jm800997s
Escherichia coli Escherichia coli MIC 12.0 ug.mL-1 10.1128/aac.01034-06
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1016/j.bmcl.2014.08.064
Escherichia coli Escherichia coli MIC 24.0 ug.mL-1 10.1021/jm900028n
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmc.2007.08.059
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1021/jm900615h
Escherichia coli Escherichia coli MIC 48.0 ug.mL-1 10.1021/jm900028n
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/jm800997s
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00795-06
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 96.0 ug.mL-1 10.1021/jm900028n
Escherichia coli Escherichia coli MIC 96.0 ug.mL-1 10.1128/aac.01034-06
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1039/d2md00459c
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00926-07
Escherichia coli Escherichia coli MIC 384.0 ug.mL-1 10.1021/jm900028n
Escherichia coli Escherichia coli MIC 1560.0 nM 10.1016/j.ejmech.2018.11.022
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1016/j.bmcl.2004.06.064
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1016/j.ejmech.2021.113156
Escherichia coli Escherichia coli MIC 2000.0 ug.mL-1 10.1021/jm800997s
Escherichia coli Escherichia coli MIC 3130.0 nM 10.1016/j.ejmech.2018.11.022
Escherichia coli Escherichia coli MIC 4400.0 nM 10.1016/j.bmcl.2013.01.073
Escherichia coli Escherichia coli MIC 400000.0 nM 10.1016/j.ejmech.2018.11.022
Escherichia coli Escherichia coli MIC nan None 10.1021/jm1000437
Escherichia coli Escherichia coli Ratio 8.0 None 10.1021/jm900028n
Escherichia coli Escherichia coli Ratio 16.0 None 10.1021/jm900028n
Escherichia coli Escherichia coli Ratio 64.0 None 10.1021/jm900028n
Eubacterium limosum Eubacterium limosum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Eubacterium limosum Eubacterium limosum MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Eubacterium limosum Eubacterium limosum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Finegoldia magna Finegoldia magna MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Finegoldia magna Finegoldia magna MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Finegoldia magna Finegoldia magna MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Fusarium graminearum Fusarium graminearum MIC 62.5 ug.mL-1 10.1039/c4md00078a
Fusobacterium mortiferum Fusobacterium mortiferum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium mortiferum Fusobacterium mortiferum MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium mortiferum Fusobacterium mortiferum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium necrophorum Fusobacterium necrophorum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium necrophorum Fusobacterium necrophorum MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium necrophorum Fusobacterium necrophorum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium nucleatum Fusobacterium nucleatum MIC 128.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium nucleatum Fusobacterium nucleatum MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium nucleatum Fusobacterium nucleatum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium sp. Fusobacterium sp. MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium sp. Fusobacterium sp. MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium sp. Fusobacterium sp. MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium varium Fusobacterium varium MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium varium Fusobacterium varium MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Fusobacterium varium Fusobacterium varium MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histone deacetylase 6 Inhibition -56.9 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -0.55 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity 0.0 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Menin Kd 15600.0 nM 10.1016/j.bmcl.2014.03.055
Homo sapiens Menin Tm 42.5 degrees C 10.1016/j.bmcl.2014.03.055
Homo sapiens Menin Tm 43.81 degrees C 10.1016/j.bmcl.2014.03.055
Homo sapiens Menin Tm 45.19 degrees C 10.1016/j.bmcl.2014.03.055
Homo sapiens microRNA 21 Inhibition nan % 10.1021/acsmedchemlett.9b00091
Homo sapiens microRNA 21 Kd 100.0 nM 10.1021/acsmedchemlett.9b00091
Homo sapiens microRNA 21 Kd 1390.0 nM 10.1021/acsmedchemlett.0c00682
Homo sapiens microRNA 21 Kd 1415.0 nM 10.1021/acsmedchemlett.0c00682
Homo sapiens microRNA 21 Kd 1950.0 nM 10.1021/acsmedchemlett.0c00682
Homo sapiens microRNA 21 Ratio 1.0 None 10.1021/acsmedchemlett.0c00682
Homo sapiens microRNA 21 Ratio 1.4 None 10.1021/acsmedchemlett.0c00682
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Phosphatidylcholine-retinol O-acyltransferase IC50 14900.0 nM 10.1016/s0960-894x(02)01073-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 IC50 8000000.0 nM 10.1021/jm300335n
Homo sapiens Vanilloid receptor IC50 400.0 nM 10.1039/C0MD00207K
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Hoylesella loescheii Hoylesella loescheii MIC 8.0 ug.mL-1 10.1128/aac.00441-08
Hoylesella loescheii Hoylesella loescheii MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Hoylesella loescheii Hoylesella loescheii MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Human immunodeficiency virus 1 Human immunodeficiency virus 1 K 120000.0 M-1 10.1016/s0960-894x(01)00823-x
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 REV Kd 180.0 nM 10.1016/s0960-894x(01)00149-4
Human immunodeficiency virus 1 Rev responsive element (RRE) RNA Kd 180.0 nM 10.1016/j.bmcl.2006.06.094
Human immunodeficiency virus 1 Rev responsive element (RRE) RNA Kd 370.0 nM 10.1016/j.bmcl.2006.06.094
Human immunodeficiency virus 1 Rev responsive element (RRE) RNA Ratio 2.1 None 10.1016/j.bmcl.2006.06.094
Klebsiella oxytoca Klebsiella oxytoca MIC 6.25 ug.mL-1 10.1007/s00044-010-9490-3
Klebsiella pneumoniae Klebsiella pneumoniae IC50 0.6 ug.mL-1 10.1021/jm900622d
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1021/jm800997s
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.25 ug.mL-1 10.1007/s00044-010-9490-3
Klebsiella pneumoniae Klebsiella pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2007.08.059
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmc.2007.08.059
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1021/jm401148j
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1021/jm800997s
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1021/jm900615h
Klebsiella pneumoniae Klebsiella pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.00556-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC90 32.0 ug.mL-1 10.1128/aac.00556-09
Lacticaseibacillus rhamnosus Lacticaseibacillus rhamnosus MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Lacticaseibacillus rhamnosus Lacticaseibacillus rhamnosus MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Lacticaseibacillus rhamnosus Lacticaseibacillus rhamnosus MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Lactiplantibacillus plantarum Lactiplantibacillus plantarum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Lactiplantibacillus plantarum Lactiplantibacillus plantarum MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Lactiplantibacillus plantarum Lactiplantibacillus plantarum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus acidophilus Lactobacillus acidophilus MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus acidophilus Lactobacillus acidophilus MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus acidophilus Lactobacillus acidophilus MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus jensenii Lactobacillus jensenii MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus jensenii Lactobacillus jensenii MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus jensenii Lactobacillus jensenii MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus sp. Lactobacillus sp. MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus sp. Lactobacillus sp. MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Lactobacillus sp. Lactobacillus sp. MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus fermentum Limosilactobacillus fermentum MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus fermentum Limosilactobacillus fermentum MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus fermentum Limosilactobacillus fermentum MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus reuteri Limosilactobacillus reuteri MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus reuteri Limosilactobacillus reuteri MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Limosilactobacillus reuteri Limosilactobacillus reuteri MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Micrococcus luteus Micrococcus luteus Activity nan None 10.1016/j.bmc.2007.03.056
Micrococcus luteus Micrococcus luteus MIC 12.5 ug.mL-1 10.1016/j.bmcl.2014.08.064
Mus musculus 3LL cell line IC50 1000000.0 nM 10.1021/acs.jmedchem.2c01293
Mus musculus J774 Activity 69.8 % 10.1016/j.ejmech.2018.08.022
Mus musculus J774 Activity 87.3 % 10.1016/j.ejmech.2018.08.022
Mus musculus Mus musculus Activity 69.8 % 10.1021/acs.jmedchem.6b00818
Mus musculus Mus musculus Activity 87.3 % 10.1021/acs.jmedchem.6b00818
Mus musculus Mus musculus LD50 24.0 mg.kg-1 10.1016/j.bmc.2017.02.068
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 780.0 nM 10.1016/j.ejmech.2018.11.022
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC nan None 10.1016/j.bmc.2010.11.001
Nocardia farcinica Nocardia farcinica MIC 16.0 ug.mL-1 10.1128/aac.00021-10
Nocardia farcinica Nocardia farcinica MIC 1024.0 ug.mL-1 10.1128/aac.00021-10
Oncorhynchus gorbuscha Salmon testes DNA Activity nan None 10.1021/acs.jnatprod.0c00946
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Paeniclostridium sordellii Paeniclostridium sordellii MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Paeniclostridium sordellii Paeniclostridium sordellii MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Paeniclostridium sordellii Paeniclostridium sordellii MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides distasonis Parabacteroides distasonis MIC 512.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides distasonis Parabacteroides distasonis MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides distasonis Parabacteroides distasonis MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides merdae Parabacteroides merdae MIC 512.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides merdae Parabacteroides merdae MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
Parabacteroides merdae Parabacteroides merdae MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Paraclostridium bifermentans Paraclostridium bifermentans MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Paraclostridium bifermentans Paraclostridium bifermentans MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Paraclostridium bifermentans Paraclostridium bifermentans MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Parvimonas micra Parvimonas micra MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Parvimonas micra Parvimonas micra MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Parvimonas micra Parvimonas micra MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC 256.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas somerae Porphyromonas somerae MIC 256.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas somerae Porphyromonas somerae MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Porphyromonas somerae Porphyromonas somerae MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Prescottella equi Prescottella equi MIC 1.56 ug.mL-1 10.1007/s00044-010-9490-3
Prevotella bivia Prevotella bivia MIC 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella bivia Prevotella bivia MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Prevotella bivia Prevotella bivia MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Prevotella corporis Prevotella corporis MIC 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella corporis Prevotella corporis MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Prevotella corporis Prevotella corporis MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Prevotella disiens Prevotella disiens MIC 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella disiens Prevotella disiens MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Prevotella disiens Prevotella disiens MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Prevotella intermedia Prevotella intermedia MIC 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella intermedia Prevotella intermedia MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Prevotella intermedia Prevotella intermedia MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Prevotella melaninogenica Prevotella melaninogenica MIC 8.0 ug.mL-1 10.1128/aac.00441-08
Prevotella melaninogenica Prevotella melaninogenica MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
Prevotella melaninogenica Prevotella melaninogenica MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Proteus vulgaris Proteus vulgaris IZ 25.29 mm 10.1007/s00044-013-0755-5
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.bmc.2007.03.056
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 40.0 % 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 0.5 ug.mL-1 10.1016/j.bmc.2007.08.059
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1128/aac.01360-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 12.5 ug.mL-1 10.1016/j.bmcl.2014.08.064
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 18.75 ug.mL-1 10.1007/s00044-012-0450-y
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/jm401148j
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/jm401148j
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/jm800997s
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1039/c4md00078a
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1128/aac.01345-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/jm401148j
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1021/jm900615h
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01034-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1021/jm1000437
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1021/jm800345u
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Aminoglycoside 3'-phosphotransferase type IIb Kcat/Km 120000.0 /M/s 10.1128/aac.01034-06
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Aminoglycoside 3'-phosphotransferase type IIb Km 17500.0 nM 10.1128/aac.01034-06
Pseudomonas putida Pseudomonas putida Activity 8.0 ug ml-1 10.1128/aac.00652-07
Raoultella planticola Raoultella planticola MIC 12.5 ug.mL-1 10.1016/j.bmcl.2014.08.064
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Rattus norvegicus ALB 37400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 200.9 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 254.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 317.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 318.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 336.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 349.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 367.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 386.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 402.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 434.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 26.9 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 28.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 29.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 33.2 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 68.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 68.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 76.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 81.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 85.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 93.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 62.4 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 67.8 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 73.8 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 78.6 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 87.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 94.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 98.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 105.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 122.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.32 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.36 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.42 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.48 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 60.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 66.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 104.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 110.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 120.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 147.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 166.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 104.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 107.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 108.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 109.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 545.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 575.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 576.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 606.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 630.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 671.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 683.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 743.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 746.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 896.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 177.2 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 224.8 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 235.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 251.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 277.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 305.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 307.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 312.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 327.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 481.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26400000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31170000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 32330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 4.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 14.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 26.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 33.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.51 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.58 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1256.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1286.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1352.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1406.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1420.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1436.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1520.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1563.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1655.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.87 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.82 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.2 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 46.94 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 48.44 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 48.92 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 49.44 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 149000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 156000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 158800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 163400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Incidence 22.0 % 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus Incidence 25.0 % 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus Incidence 80.0 % 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus Incidence 98.0 % 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus LDH 83.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 94.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 107.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 167.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 224.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 230.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 85.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7138.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7627.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7805.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8427.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9048.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9629.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 81.52 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 82.08 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 83.46 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.12 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 88.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 19.85 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.26 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.58 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.94 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.47 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.72 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.57 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.0 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.28 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.57 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 315800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 318000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 324700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 337400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 389700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 396000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 396300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 399200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.1 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.18 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.2 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.12 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.9 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.97 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.3 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.68 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.34 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 51.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 72.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 76.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 80.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 92.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.44 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.54 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.68 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.16 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.28 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.95 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.88 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.3 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 362.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 528.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 785.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 980.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1049.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1521.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus No. of tumors 0.5 None 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus No. of tumors 1.13 None 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus No. of tumors 3.0 None 10.1016/s0960-894x(99)00438-2
Rattus norvegicus Rattus norvegicus PHOS 81.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 101.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 103.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 105.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 106.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 120.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 138.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1072670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1077000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1108330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1152670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1208100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1211330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1226000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1274600.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1275330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1531200.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.16 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.46 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.92 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.99 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.58 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.71 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.96 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60600.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 65200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 66400.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5340000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5360000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5460000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5490000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5670000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7260000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7450000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 8010000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 8060000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.02 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.3 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 148.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 148.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.37 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 151.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 151.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 4.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 6.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 11.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 15.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 6840.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 7500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8230.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8690.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10680.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10770.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12820.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 13040.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Schaalia meyeri Schaalia meyeri MIC 2.0 ug.mL-1 10.1128/aac.00441-08
Schaalia meyeri Schaalia meyeri MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
Schaalia meyeri Schaalia meyeri MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 13.52 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.07 % 10.6019/CHEMBL4495565
Shigella flexneri Shigella flexneri Activity 8.0 ug ml-1 10.1128/aac.00652-07
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2007.03.056
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmcl.2013.01.073
Staphylococcus aureus Staphylococcus aureus IZ 9.0 mm 10.1021/np010020u
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2018.08.022
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.6b00818
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/ml200202y
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.01.027
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2010.09.084
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm1000437
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm401148j
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm800997s
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm900615h
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1039/c4md00078a
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00570-09
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2018.08.018
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/jm401148j
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/jm800345u
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/jm900615h
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00247-08
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1016/j.bmcl.2014.08.064
Staphylococcus aureus Staphylococcus aureus MIC 18.75 ug.mL-1 10.1007/s00044-012-0450-y
Staphylococcus aureus Staphylococcus aureus MIC 25.0 ug.mL-1 10.1007/s00044-010-9490-3
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmc.2007.08.059
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1021/jm401148j
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1021/jm900615h
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1016/j.ejmech.2020.112686
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/ml200202y
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1128/aac.00570-09
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1016/j.bmc.2010.11.001
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1021/jm800997s
Staphylococcus aureus Staphylococcus aureus MIC 125.0 ug.mL-1 10.1039/c4md00078a
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2018.08.022
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/acs.jmedchem.6b00818
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/jm401148j
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1021/jm900615h
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2018.08.018
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/jm1000437
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/jm800345u
Staphylococcus aureus Staphylococcus aureus MIC 384.0 ug.mL-1 10.1021/jm900028n
Staphylococcus aureus Staphylococcus aureus MIC 1000.0 nM 10.1016/j.ejmech.2015.06.013
Staphylococcus aureus Staphylococcus aureus MIC 1100.0 nM 10.1016/j.bmcl.2013.01.073
Staphylococcus aureus Staphylococcus aureus MIC 1560.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC 1600.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC 3000.0 nM 10.1016/j.bmcl.2004.06.064
Staphylococcus aureus Staphylococcus aureus MIC 3200.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC 6300.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC 100000.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC 125000.0 nM 10.1021/acs.jmedchem.1c01809
Staphylococcus aureus Staphylococcus aureus MIC 200000.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC 240000.0 nM 10.1016/j.ejmech.2015.06.013
Staphylococcus aureus Staphylococcus aureus MIC 400000.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus aureus Staphylococcus aureus MIC99 16.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Staphylococcus aureus Staphylococcus aureus MIC99 128.0 ug ml-1 10.1021/acs.jmedchem.2c01293
Staphylococcus aureus Staphylococcus aureus Ratio 240.0 None 10.1016/j.ejmech.2015.06.013
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1016/j.bmc.2007.03.056
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1021/jm1000437
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1021/jm1000437
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1021/jm800345u
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1.0 ug.mL-1 10.1021/jm800345u
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1560.0 nM 10.1016/j.ejmech.2018.11.022
Staphylococcus epidermidis Staphylococcus epidermidis MIC95 7.81 uM 10.1016/j.bmcl.2013.12.054
Staphylococcus epidermidis Staphylococcus epidermidis MIC95 15.62 uM 10.1016/j.bmcl.2013.12.054
Staphylococcus xylosus Staphylococcus xylosus MIC 0.2 ug.mL-1 10.1007/s00044-010-9490-3
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 64.0 ug.mL-1 10.1128/aac.00795-06
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 512.0 ug.mL-1 10.1021/jm1000437
Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC 512.0 ug.mL-1 10.1128/aac.00795-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1021/jm1000437
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1021/jm1000437
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1021/jm800345u
Streptococcus pyogenes Streptococcus pyogenes MIC nan None 10.1016/j.ejmech.2018.11.022
Streptomyces coelicolor Streptomyces coelicolor MIC 0.2 ug.mL-1 10.1128/aac.00388-08
Streptomyces coelicolor Streptomyces coelicolor MIC 0.3 ug.mL-1 10.1128/aac.00388-08
Streptomyces coelicolor Streptomyces coelicolor MIC 0.5 ug.mL-1 10.1128/aac.00388-08
Streptomyces coelicolor Streptomyces coelicolor MIC 0.8 ug.mL-1 10.1128/aac.00388-08
Sus scrofa LLC-PK1 Activity nan None 10.1128/aac.01680-07
Thomasclavelia ramosa Thomasclavelia ramosa MIC 1.0 ug.mL-1 10.1128/aac.00441-08
Thomasclavelia ramosa Thomasclavelia ramosa MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
Thomasclavelia ramosa Thomasclavelia ramosa MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
None ADMET Activity 50.0 % 10.1016/j.ejmech.2018.11.022
None ADMET Activity nan None 10.1016/j.ejmech.2018.11.022
None ADMET C50 0.34 uM 10.1021/jm00385a015
None ADMET Delta Tm 0.0 degrees C 10.1039/c4md00165f
None ADMET Delta Tm 0.2 degrees C 10.1039/c4md00165f
None ADMET Delta Tm 0.5 degrees C 10.1039/c4md00165f
None ADMET Delta Tm 1.0 degrees C 10.1039/c4md00165f
None ADMET Inhibition 20.0 % 10.1016/j.bmcl.2020.127218
None ADMET K2 0.018 min-1 10.1016/S0960-894X(97)00339-9
None ADMET K2 0.062 min-1 10.1016/S0960-894X(97)00339-9
None ADMET K2 nan None 10.1016/S0960-894X(97)00339-9
None ADMET Kill at C50 82.0 % 10.1021/jm00385a015
None ADMET LD90 0.46 uM 10.1021/jm00385a015
None ADMET log10(%HIA +10) 1.041 None 10.1016/j.ejmech.2010.11.005
None ADMET Uptake at C50 1.6 None 10.1021/jm00385a015
None Erythrocyte Activity nan None 10.1021/acs.jmedchem.2c01293
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LTKB_BD DILI severity score nan None 10.1016/j.drudis.2011.05.007
None Lipid bilayer Activity nan None 10.1038/nchembio751
None NON-PROTEIN TARGET Activity 8.0 ug ml-1 10.1128/aac.00652-07
None NON-PROTEIN TARGET IZ 25.78 mm 10.1007/s00044-013-0755-5
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 125.0 ug.mL-1 10.1128/aac.00261-06
None NON-PROTEIN TARGET MIC 128.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 250.0 ug.mL-1 10.1128/aac.00261-06
None NON-PROTEIN TARGET MIC 256.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 500.0 ug.mL-1 10.1128/aac.00261-06
None NON-PROTEIN TARGET MIC 512.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC 1024.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 64.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 128.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 256.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 512.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC50 1024.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC90 512.0 ug.mL-1 10.1128/aac.00441-08
None NON-PROTEIN TARGET MIC90 1024.0 ug.mL-1 10.1128/aac.00441-08
None No relevant target Kd 100.0 nM 10.1021/jm030650o
None No relevant target Kd 1000.0 nM 10.1021/jm030650o
None No relevant target Kd 2600.0 nM 10.1021/jm100231t
None No relevant target solubility nan None 10.1021/acs.jnatprod.0c00946
None Nucleic Acid Activity 0.06 /s 10.1038/nchembio.274
None Nucleic Acid Activity 0.31 /s 10.1038/nchembio.274
None Nucleic Acid Activity 6.0 % 10.1038/nchembio.274
None Nucleic Acid Activity 10.0 % 10.1038/nchembio.274
None Nucleic Acid Activity 52.0 % 10.1038/nchembio.274
None Nucleic Acid Activity 70.3 % 10.1038/nchembio.274
None Nucleic Acid Activity nan None 10.1016/j.bmcl.2011.12.103
None Nucleic Acid Activity nan None 10.1128/aac.00926-07
None Nucleic Acid Delta Tm 0.0 degrees C 10.1016/j.bmcl.2009.07.079
None Nucleic Acid Delta Tm 0.2 degrees C 10.1016/j.bmcl.2011.06.058
None Nucleic Acid Delta Tm 2.0 degrees C 10.1016/j.bmcl.2013.08.014
None Nucleic Acid DNA peak exclusion 100.0 % 10.1016/s0960-894x(01)00115-9
None Nucleic Acid EC50 7.0 nM 10.1016/j.bmcl.2010.10.001
None Nucleic Acid FC 1.5 None 10.1038/nchembio.274
None Nucleic Acid FC 3.0 None 10.1038/nchembio.274
None Nucleic Acid Frel 0.46 None 10.1016/j.bmcl.2005.02.007
None Nucleic Acid IC50 417.0 nM 10.1016/j.bmcl.2011.06.058
None Nucleic Acid IC50 920.0 nM 10.1016/0960-894X(95)00467-8
None Nucleic Acid IC50 1474.0 nM 10.1016/j.bmcl.2013.08.014
None Nucleic Acid IC50 150000.0 nM 10.1039/c4md00165f
None Nucleic Acid IC50 192000.0 nM 10.1039/c4md00165f
None Nucleic Acid IC50 378000.0 nM 10.1039/c4md00165f
None Nucleic Acid IC50 684000.0 nM 10.1039/c4md00165f
None Nucleic Acid IC50 nan None 10.1039/c4md00165f
None Nucleic Acid Inhibition 10.0 % 10.1016/j.bmcl.2011.12.103
None Nucleic Acid K 1.6 10'7/M 10.1039/c4md00165f
None Nucleic Acid K 3.0 10'7/M 10.1039/c4md00165f
None Nucleic Acid K nan None 10.1039/c4md00165f
None Nucleic Acid Kd 60.0 nM 10.1021/jm9000659
None Nucleic Acid Kd 91.0 nM 10.1016/s0960-894x(01)00760-0
None Nucleic Acid Kd 120.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 140.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 160.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 380.0 nM 10.1016/s0960-894x(00)00299-7
None Nucleic Acid Kd 380.0 nM 10.1016/s0960-894x(01)00760-0
None Nucleic Acid Kd 410.0 nM 10.1016/s0960-894x(01)00760-0
None Nucleic Acid Kd 440.0 nM 10.1016/s0960-894x(00)00299-7
None Nucleic Acid Kd 470.0 nM 10.1016/s0960-894x(01)00760-0
None Nucleic Acid Kd 1000.0 nM 10.1016/j.bmcl.2011.06.058
None Nucleic Acid Kd 1100.0 nM 10.1016/j.bmcl.2011.06.084
None Nucleic Acid Kd 1500.0 nM 10.1016/j.bmcl.2011.06.084
None Nucleic Acid Kd 1550.0 nM 10.1021/jm900615h
None Nucleic Acid Kd 3970.0 nM 10.1016/s0960-894x(02)00342-6
None Nucleic Acid Kd 4340.0 nM 10.1016/s0960-894x(01)00760-0
None Nucleic Acid Kd 6000.0 nM 10.1016/j.bmcl.2011.12.103
None Nucleic Acid Kd 11000.0 nM 10.1016/j.bmcl.2011.12.103
None Nucleic Acid MIC 1000.0 nM 10.1021/jm970372r
None Nucleic Acid Tm 48.0 degrees C 10.1016/j.bmcl.2011.12.103
None Nucleic Acid Tm 50.0 degrees C 10.1016/j.bmcl.2011.12.103
None Nucleic Acid Tm 69.1 degrees C 10.1016/j.bmcl.2011.06.058
None Nucleic Acid Tm 70.0 degrees C 10.1016/j.bmcl.2011.12.103
None Nucleic Acid tRNA peak exclusion 77.8 % 10.1016/s0960-894x(01)00115-9
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Ribosomal RNA A-site Activity -474.3 None 10.1016/j.bmcl.2004.06.064
None Ribosomal RNA A-site IC50 76.0 nM 10.1016/j.ejmech.2018.11.022
None Ribosomal RNA A-site IC50 87.0 nM 10.1016/j.ejmech.2018.11.022
None Ribosomal RNA A-site IC50 139.0 nM 10.1016/j.ejmech.2018.11.022
None Ribosomal RNA A-site Kd 19.0 nM 10.1016/s0960-894x(00)00615-6
None Ribosome IC50 252000.0 nM 10.1016/j.bmcl.2010.10.001
None Unchecked Activity 70.0 % 10.1016/j.bmc.2015.07.062
None Unchecked Activity nan None 10.1016/j.bmc.2008.02.056
None Unchecked Activity nan None 10.1016/j.bmc.2019.05.009
None Unchecked Activity nan None 10.1016/j.bmcl.2016.10.076
None Unchecked Activity nan None 10.1016/j.bmcl.2022.128608
None Unchecked Delta Tm 10.5 degrees C 10.1016/j.bmcl.2016.10.076
None Unchecked Delta Tm 10.8 degrees C 10.1016/j.bmcl.2016.10.076
None Unchecked Denaturation rate constant 0.095 min-1 10.1016/s0960-894x(03)00085-4
None Unchecked FC 1.2 None 10.1039/C7MD00285H
None Unchecked FC 70.0 None 10.1039/C7MD00285H
None Unchecked IC50 7.9 nM 10.1016/j.bmc.2010.07.034
None Unchecked IC50 9.0 nM 10.1016/s0960-894x(03)00085-4
None Unchecked IC50 50.0 nM 10.1016/s0960-894x(03)00085-4
None Unchecked IC50 7000.0 nM 10.1016/j.bmcl.2005.07.082
None Unchecked IC50 11000.0 nM 10.1021/jm701575k
None Unchecked IC50 35000.0 nM 10.1016/j.bmcl.2005.07.082
None Unchecked IC50 76700.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 88200.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 93700.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 125000.0 nM 10.1016/j.ejmech.2019.112008
None Unchecked IC50 143000.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked IC50 178000.0 nM 10.1016/j.ejmech.2019.112008
None Unchecked IC50 nan None 10.1021/jm900028n
None Unchecked IC50 nan None None
None Unchecked Inhibition 20.0 % 10.1016/j.bmc.2019.115121
None Unchecked Inhibition 20.4 % 10.1016/j.bmcl.2016.10.076
None Unchecked Inhibition 25.0 % 10.1016/j.ejmech.2019.112008
None Unchecked Inhibition 60.0 % 10.1016/j.bmc.2015.07.062
None Unchecked Inhibition 76.0 % 10.1016/s0960-894x(03)00085-4
None Unchecked Inhibition 100.0 % 10.1016/j.ejmech.2019.112008
None Unchecked Inhibition 100.0 % 10.1016/s0960-894x(03)00085-4
None Unchecked Inhibition nan % 10.1016/j.bmc.2015.07.062
None Unchecked Inhibition nan % 10.1016/j.ejmech.2018.11.022
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.9b00091
None Unchecked Inhibition nan % 10.1128/aac.00274-08
None Unchecked K 3.4 M-1 10.1016/s0960-894x(98)00718-5
None Unchecked K 4.0 M-1 10.1016/s0960-894x(98)00718-5
None Unchecked K 8.0 M-2 10.1016/s0960-894x(98)00718-5
None Unchecked Ka 1.6 10^-5M 10.1016/j.bmcl.2022.128608
None Unchecked Ka 2.6 10'7/M 10.1016/j.bmcl.2008.05.090
None Unchecked Ka 7.0 10'4/M 10.1016/j.bmcl.2008.05.090
None Unchecked Ka 9.9 10'6/M 10.1016/j.bmcl.2008.05.090
None Unchecked Kcat 1.59 /s 10.1128/aac.01570-09
None Unchecked Kcat 1.61 /s 10.1021/jm800997s
None Unchecked Kcat 2.4 /s 10.1021/jm900028n
None Unchecked Kcat/Km 1.5 10'5/s/M 10.1128/aac.01570-09
None Unchecked Kcat/Km 26.8 10'4/M/s 10.1021/jm800997s
None Unchecked Kcat/Km 42.0 10'-4/M/s 10.1021/jm900028n
None Unchecked Kd 1.0 nM 10.1016/j.bmc.2019.115121
None Unchecked Kd 5.0 nM 10.1016/j.bmc.2019.115121
None Unchecked Kd 100.0 nM 10.1016/j.bmc.2019.115121
None Unchecked Kd 308.0 nM 10.1016/j.bmc.2007.08.053
None Unchecked Kd 313.0 nM 10.1016/j.bmc.2007.08.053
None Unchecked Kd 320.0 nM 10.1016/j.bmc.2007.08.053
None Unchecked Kd 350.0 nM 10.1016/s0960-894x(01)00602-3
None Unchecked Kd 1100.0 nM 10.1016/j.bmc.2019.115121
None Unchecked Kd 1148.0 nM 10.1016/j.bmcl.2013.01.073
None Unchecked Kd 1270.0 nM 10.1016/j.bmcl.2013.01.073
None Unchecked Kd 1880.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 2300.0 nM 10.1016/j.bmc.2007.08.053
None Unchecked Kd 6300.0 nM 10.1016/j.bmc.2007.08.053
None Unchecked Kd 8000.0 nM 10.1016/j.bmc.2008.02.056
None Unchecked Kd 11300.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 11600.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 11700.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 15200.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 779000.0 nM 10.1016/j.bmc.2019.05.009
None Unchecked Ki 13500.0 nM 10.1016/s0960-894x(98)00718-5
None Unchecked Ki 18800.0 nM 10.1016/j.bmcl.2014.03.055
None Unchecked Ki nan None None
None Unchecked Km 5700.0 nM 10.1021/jm900028n
None Unchecked Km 6000.0 nM 10.1021/jm800997s
None Unchecked Km 10600.0 nM 10.1128/aac.01570-09
None Unchecked Ratio 1.0 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio IC50 20.0 None 10.1016/j.bmc.2019.115121
None Unchecked Ratio IC50 200.0 None 10.1016/j.bmc.2019.115121
None Unchecked Selectivity ratio 100.0 None 10.1016/j.bmc.2019.115121
None Unchecked Selectivity ratio 1100.0 None 10.1016/j.bmc.2019.115121
None Unchecked Tm 24.0 degrees C 10.1016/j.bmcl.2022.128608
None Unchecked Tm 62.9 degrees C 10.1016/j.bmcl.2008.05.090
None Unchecked Tm 64.2 degrees C 10.1016/j.bmcl.2014.12.079
None Unchecked Tm 64.7 degrees C 10.1016/j.bmcl.2008.05.090
None Unchecked Tm 65.8 degrees C 10.1016/j.bmcl.2008.05.090
None Unchecked Vmax 3.22 umol/min/mg 10.1021/jm800997s

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT004414 CC(=O)[32S].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@H]3[C@H](O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@@H](N)C[C@@H](N)[C@@H]3O)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>CC(=O)NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O None
AKRT004415 CC(=O)[32S].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@H]3[C@H](O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@@H](N)C[C@@H](N)[C@@H]3O)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>CC(=O)N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N None
AKRT004657 CC(=O)[CoA].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>CC(=O)NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O enzymemap_32252
AKRT004658 CC(=O)[CoA].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>CC(=O)N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N enzymemap_32207
AKRT004792 CC(C(=O)O)C(=O)[CoA].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>CC(C(=O)O)C(=O)N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N enzymemap_32194
AKRT007187 CCC(=O)[CoA].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>CCC(=O)N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N enzymemap_32198
AKRT017776 NCC(=O)[CoA].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>NCC(=O)N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1N enzymemap_32189
AKRT018450 NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](OP(=O)(O)O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O enzymemap_45517
AKRT018451 NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](C=O)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O enzymemap_43063
AKRT018484 NC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O RXN-13205
AKRT022709 O=C(O)CC(=O)[CoA].NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O>>NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](NC(=O)CC(=O)O)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O enzymemap_32193