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name Structure Reference Source Properties Activities Metabolism

Theophylline; Compd. with sodium glycinate

AlkaPlorer ID: AK005442

Synonym: Theophylline sodium glycinate, Pemophyllin

IUPAC Name: 1,3-dimethyl-7H-purine-2,6-dione

Structure

SMILES: CN1C(=O)C2=C(N=CN2)N(C)C1=O

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InChI: InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

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InChIKey: ZFXYFBGIUFBOJW-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Ginkgo biloba Ginkgo Ginkgoaceae Ginkgoales Ginkgoopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 180.167

TPSA？: 72.68

MolLogP？: -1.0397000000000003

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 9.61 % 10.6019/CHEMBL4513141
Bacillus anthracis Anthrax lethal factor Potency 794.3 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 56234.1 nM None
Bos taurus Adenosine A1 receptor IC50 2430.0 nM 10.1021/jm00146a016
Bos taurus Adenosine A1 receptor IC50 12700.0 nM 10.1021/jm00146a016
Bos taurus Adenosine A1 receptor IC50 3019951720402.02 nM 10.1021/jm00146a016
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1016/j.bmc.2008.04.039
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1021/jm000936i
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1021/jm031136l
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1021/jm0504149
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1021/jm060373w
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1021/jm8014876
Bos taurus Adenosine A1 receptor Ki 3800.0 nM 10.1021/jm991096e
Bos taurus Adenosine A1 receptor Ki 6000.0 nM 10.1021/jm00107a046
Bos taurus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm00044a018
Bos taurus Adenosine A1 receptor Ki 20000.0 nM 10.1021/jm00345a001
Bos taurus Heart phosphodiesterase IC50 92000.0 nM 10.1021/jm00096a008
Bos taurus Heart phosphodiesterase IC50 286000.0 nM 10.1021/jm00138a002
Bos taurus Heart phosphodiesterase IC50 412000.0 nM 10.1021/jm00138a002
Bos taurus Heart phosphodiesterase IC50 412000.0 nM 10.1021/jm00138a027
Bos taurus PDE7B protein IC50 1720000.0 nM 10.1007/s00044-008-9125-0
Bos taurus PDE7B protein Ratio 1.0 None 10.1007/s00044-008-9125-0
Bos taurus Phosphodiesterase 1A IC50 500000.0 nM 10.1021/jm00128a028
Bos taurus Phosphodiesterase 1B Inhibition 46.0 % 10.1021/jm00030a007
Bos taurus Phosphodiesterase 2A Inhibition 0.0 % 10.1021/jm00030a007
Bos taurus Phosphodiesterase 3B IC50 90000.0 nM 10.1021/jm00346a017
Bos taurus Phosphodiesterase 3B IC50 210000.0 nM 10.1021/jm00346a017
Bos taurus Phosphodiesterase 3B Ki 77000.0 nM 10.1021/jm00346a017
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans Inhibition 3.65 % 10.6019/CHEMBL4513141
Canis lupus familiaris Canis familiaris CL 1.5 mL.min-1.kg-1 10.1021/jm991030j
Canis lupus familiaris Canis familiaris Clearance 0.2 ul min-1 10.1021/jm991030j
Cavia porcellus Adenosine A1 receptor EC15 62.0 uM 10.1021/jm00100a008
Cavia porcellus Adenosine A1 receptor Ki 9800.0 nM 10.1021/jm00062a010
Cavia porcellus Adenosine A1 receptor Ki 9800.0 nM 10.1021/jm00100a008
Cavia porcellus Adenosine A1 receptor Ki 13000.0 nM 10.1021/jm00083a018
Cavia porcellus Adenosine A1 receptor Ki 23000.0 nM 10.1021/jm00069a009
Cavia porcellus Adenosine A1 receptor Ki 23000.0 nM 10.1021/jm00083a018
Cavia porcellus Adenosine A1 receptor Ki 23000.0 nM 10.1021/jm00090a027
Cavia porcellus Adenosine A1 receptor Ki 23000.0 nM 10.1021/jm00094a022
Cavia porcellus Adenosine A1 receptor Ki 23000.0 nM 10.1021/jm00105a072
Cavia porcellus Adenosine A2a receptor Ki 13000.0 nM 10.1021/jm00345a001
Cavia porcellus Adenosine A2a receptor Ki 14000.0 nM 10.1021/jm00157a035
Cavia porcellus Adenosine A2a receptor Ki 14000.0 nM 10.1021/jm00382a018
Cavia porcellus Adenosine A2a receptor Ki 16600.0 nM 10.1021/jm00100a008
Cavia porcellus Cavia porcellus Activity nan None 10.1021/jm00149a029
Cavia porcellus Cavia porcellus Decrease 56.0 % 10.1021/jm50001a019
Cavia porcellus Cavia porcellus Decrease 59.0 % 10.1021/jm50001a019
Cavia porcellus Cavia porcellus Decrease 72.0 % 10.1021/jm50001a019
Cavia porcellus Cavia porcellus EC15 62.0 uM 10.1021/jm00062a010
Cavia porcellus Cavia porcellus EC20 88.0 uM 10.1021/jm970089s
Cavia porcellus Cavia porcellus EC50 28000.0 nM 10.1021/jm970089s
Cavia porcellus Cavia porcellus EC50 28200.0 nM 10.1021/jm00062a010
Cavia porcellus Cavia porcellus ED15 20.2 mg kg-1 10.1021/jm00062a010
Cavia porcellus Cavia porcellus ED15 20.2 mg kg-1 i.d. 10.1021/jm00100a008
Cavia porcellus Cavia porcellus ED50 18.5 mg.kg-1 10.1021/jm00185a008
Cavia porcellus Cavia porcellus ED50 23.4 mg.kg-1 10.1021/jm00062a010
Cavia porcellus Cavia porcellus ED50 23.4 mg.kg-1 10.1021/jm00100a008
Cavia porcellus Cavia porcellus ED50 43.0 nM 10.1021/jm00368a018
Cavia porcellus Cavia porcellus ED50 70.8 uM 10.1021/jm00379a004
Cavia porcellus Cavia porcellus Emax 100.0 % 10.1016/s0960-894x(98)00056-0
Cavia porcellus Cavia porcellus IC50 3000.0 nM 10.1021/jm00400a022
Cavia porcellus Cavia porcellus IC50 6520.0 nM 10.1021/jm00100a009
Cavia porcellus Cavia porcellus IC50 6520.0 nM 10.1021/jm00104a013
Cavia porcellus Cavia porcellus IC50 10000.0 nM 10.1021/jm00400a022
Cavia porcellus Cavia porcellus IC50 42000.0 nM 10.1021/jm00376a027
Cavia porcellus Cavia porcellus Increase 55.0 % 10.1016/S0960-894X(01)80748-4
Cavia porcellus Cavia porcellus Inhibition 60.0 % 10.1021/jm000970x
Cavia porcellus Cavia porcellus Kd 29512.09 nM 10.1021/jm970089s
Cavia porcellus Cavia porcellus MCT 343.0 s 10.1021/jm00104a013
Cavia porcellus Cavia porcellus MCT 389.0 s 10.1021/jm00104a013
Cavia porcellus Cavia porcellus MCT 396.0 s 10.1021/jm00100a009
Cavia porcellus Cavia porcellus MCT 414.0 s 10.1021/jm00100a009
Cavia porcellus Cavia porcellus MCT 414.0 s 10.1021/jm00104a013
Cavia porcellus Cavia porcellus MIC 30.0 ug.mL-1 10.1021/jm000970x
Cavia porcellus Cavia porcellus MLD 300.0 mg kg-1 10.1021/jm00104a013
Cavia porcellus Cavia porcellus pD2 4.0 None 10.1016/S0960-894X(01)80748-4
Cavia porcellus Cavia porcellus pD2 4.69 None 10.1016/s0960-894x(98)00056-0
Cavia porcellus Cavia porcellus PD50 75.0 mg kg-1 10.1021/jm00168a044
Cavia porcellus Cavia porcellus Protection 20.0 % 10.1021/jm00183a012
Cavia porcellus Cavia porcellus Relaxation 77.1 % 10.1016/s0960-894x(98)00056-0
Cavia porcellus Cavia porcellus Survival 100.0 % 10.1016/j.ejmech.2014.01.045
Cavia porcellus Cavia porcellus TIME 0.02472 hr 10.1016/j.ejmech.2014.01.045
Cavia porcellus Cavia porcellus TIME 0.02556 hr 10.1016/j.ejmech.2014.01.045
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cavia porcellus Trachea IC50 11570.0 nM 10.1016/j.ejmech.2017.07.025
Cryptococcus neoformans Cryptococcus neoformans Inhibition 7.56 % 10.6019/CHEMBL4513141
Cryptosporidium parvum Cryptosporidium parvum IC50 nan None 10.1016/j.bmc.2010.01.068
Entamoeba histolytica Entamoeba histolytica IC50 nan None 10.1016/j.bmc.2010.01.068
Escherichia coli Escherichia coli Inhibition 7.82 % 10.6019/CHEMBL4513141
Homo sapiens 786-0 GI50 100000.0 nM None
Homo sapiens A549 GI50 100000.0 nM None
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN GI50 100000.0 nM None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor Affinity constant 10.0 uM 10.1021/jm00345a001
Homo sapiens Adenosine A1 receptor IC50 17104.0 nM None
Homo sapiens Adenosine A1 receptor Kd 12000.0 nM 10.1021/jm040842z
Homo sapiens Adenosine A1 receptor KD hydro 2.5 mM 10.1021/jm040842z
Homo sapiens Adenosine A1 receptor Ki 0.6 nM 10.1016/j.bmcl.2004.11.044
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1016/j.bmc.2008.04.039
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1021/jm031136l
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1021/jm0504149
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1021/jm060373w
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1021/jm070123v
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1021/jm8014876
Homo sapiens Adenosine A1 receptor Ki 6200.0 nM 10.1021/jm900413e
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1016/j.bmc.2010.01.072
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1016/j.bmc.2013.09.044
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1016/j.ejmech.2019.111879
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1016/j.ejmech.2021.113907
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1021/acs.jmedchem.9b01572
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1039/C5MD00573F
Homo sapiens Adenosine A1 receptor Ki 6770.0 nM 10.1039/C8MD00070K
Homo sapiens Adenosine A1 receptor Ki 6920.0 nM 10.1021/jm051268+
Homo sapiens Adenosine A1 receptor Ki 8500.0 nM 10.1021/np9904152
Homo sapiens Adenosine A1 receptor Ki 9977.0 nM None
Homo sapiens Adenosine A1 receptor Ki 10100.0 nM 10.1016/j.bmc.2010.02.014
Homo sapiens Adenosine A2a receptor AC50 5900.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor EC50 28200.0 nM 10.1021/jm00100a008
Homo sapiens Adenosine A2a receptor FC -1.8 None 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor FC -0.4 None 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor FC -0.1 None 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor FC 0.0 None 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor FC 0.1 None 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor FC nan None 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor IC50 12007.0 nM None
Homo sapiens Adenosine A2a receptor Inhibition 2100.0 % 10.1021/jm991096e
Homo sapiens Adenosine A2a receptor K nan None 10.1021/acsmedchemlett.2c00099
Homo sapiens Adenosine A2a receptor Kd 1642.33 nM 10.6019/CHEMBL3885741
Homo sapiens Adenosine A2a receptor Kd 3162.28 nM 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor Kd 3630.0 nM 10.1021/acsmedchemlett.2c00099
Homo sapiens Adenosine A2a receptor Ki 0.6 nM 10.1016/j.bmcl.2004.11.044
Homo sapiens Adenosine A2a receptor Ki 1700.0 nM 10.1016/j.bmcl.2012.10.112
Homo sapiens Adenosine A2a receptor Ki 1710.0 nM 10.1016/j.ejmech.2019.111879
Homo sapiens Adenosine A2a receptor Ki 1710.0 nM 10.1016/j.ejmech.2021.113907
Homo sapiens Adenosine A2a receptor Ki 1710.0 nM 10.1021/acs.jmedchem.9b01572
Homo sapiens Adenosine A2a receptor Ki 1710.0 nM 10.1039/C5MD00573F
Homo sapiens Adenosine A2a receptor Ki 1710.0 nM 10.1039/C8MD00070K
Homo sapiens Adenosine A2a receptor Ki 2030.0 nM 10.1016/j.bmcl.2012.10.112
Homo sapiens Adenosine A2a receptor Ki 4200.0 nM 10.1021/jm900413e
Homo sapiens Adenosine A2a receptor Ki 6700.0 nM 10.1016/j.bmc.2010.01.072
Homo sapiens Adenosine A2a receptor Ki 6700.0 nM 10.1016/j.bmc.2013.09.044
Homo sapiens Adenosine A2a receptor Ki 6700.0 nM 10.1021/jm051268+
Homo sapiens Adenosine A2a receptor Ki 6741.0 nM None
Homo sapiens Adenosine A2a receptor Ki 7900.0 nM 10.1016/j.bmc.2008.04.039
Homo sapiens Adenosine A2a receptor Ki 7900.0 nM 10.1021/jm0504149
Homo sapiens Adenosine A2a receptor Ki 7900.0 nM 10.1021/jm060373w
Homo sapiens Adenosine A2a receptor Ki 7900.0 nM 10.1021/jm070123v
Homo sapiens Adenosine A2a receptor Ki 7900.0 nM 10.1021/jm8014876
Homo sapiens Adenosine A2a receptor Ki 10000.0 nM 10.1021/jm2003798
Homo sapiens Adenosine A2a receptor Ki 18500.0 nM 10.1016/j.bmc.2010.02.014
Homo sapiens Adenosine A2a receptor Ki 21000.0 nM 10.1021/jm000936i
Homo sapiens Adenosine A2a receptor Ki 21000.0 nM 10.1021/jm031136l
Homo sapiens Adenosine A2a receptor Ki 21000.0 nM 10.1021/jm0504149
Homo sapiens Adenosine A2a receptor Ki 21000.0 nM 10.1021/jm060373w
Homo sapiens Adenosine A2a receptor Ki 25000.0 nM 10.1021/jm00044a018
Homo sapiens Adenosine A2a receptor Ki nan None 10.1021/acsmedchemlett.2c00099
Homo sapiens Adenosine A2b receptor Ki 2700.0 nM 10.1016/j.bmc.2010.02.014
Homo sapiens Adenosine A2b receptor Ki 7059.0 nM 10.1016/j.bmcl.2004.11.044
Homo sapiens Adenosine A2b receptor Ki 7850.0 nM 10.1021/jm900413e
Homo sapiens Adenosine A2b receptor Ki 9000.0 nM 10.1016/j.ejmech.2016.11.007
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1016/j.bmc.2010.01.072
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1016/j.bmc.2013.09.044
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1016/j.ejmech.2010.04.039
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1016/j.ejmech.2019.111879
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1016/j.ejmech.2021.113907
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1021/acs.jmedchem.5b01586
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1021/jm0104318
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1021/jm049418o
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1021/jm051268+
Homo sapiens Adenosine A2b receptor Ki 9070.0 nM 10.1039/C8MD00070K
Homo sapiens Adenosine A2b receptor Ki nan None 10.1021/jm4011669
Homo sapiens Adenosine A2 receptor Affinity constant 10.0 uM 10.1021/jm00345a001
Homo sapiens Adenosine A2 receptor Ki 13800.0 nM 10.1021/jm00118a032
Homo sapiens Adenosine A2 receptor Ki 14000.0 nM 10.1021/jm00118a032
Homo sapiens Adenosine A2 receptor Ki 14000.0 nM 10.1021/jm00126a014
Homo sapiens Adenosine A2 receptor Ki 16600.0 nM 10.1021/jm00062a010
Homo sapiens Adenosine A3 receptor AC50 23013.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki 14.0 nM 10.1016/j.bmcl.2004.11.044
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1016/j.bmc.2010.01.072
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1016/j.bmc.2013.09.044
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1016/j.bmcl.2012.10.112
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1016/j.ejmech.2019.111879
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1016/j.ejmech.2021.113907
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1021/jm051268+
Homo sapiens Adenosine A3 receptor Ki 22300.0 nM 10.1039/C8MD00070K
Homo sapiens Adenosine A3 receptor Ki 29400.0 nM 10.1016/j.bmcl.2012.10.112
Homo sapiens Adenosine A3 receptor Ki 52300.0 nM 10.1021/jm900413e
Homo sapiens Adenosine A3 receptor Ki 85100.0 nM 10.1016/j.bmc.2010.02.014
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1016/j.bmc.2008.04.039
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm000936i
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm031136l
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm0504149
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm060373w
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm070123v
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm8014876
Homo sapiens Adenosine A3 receptor Ki 86000.0 nM 10.1021/jm991096e
Homo sapiens Adenosine A3 receptor Ki 86400.0 nM 10.1021/acs.jmedchem.9b01572
Homo sapiens Adenosine A3 receptor Ki nan None 10.1021/jm4011669
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adenosine receptor Affinity constant nan None 10.1021/jm00345a001
Homo sapiens Adenosine receptors; A1 & A2 Ratio 0.7 None 10.1021/jm00069a009
Homo sapiens Adenosine receptors; A1 & A3 Ratio Ki 0.07 None 10.1021/jm0504149
Homo sapiens Adenosine receptors; A1 & A3 Ratio Ki 0.092 None 10.1021/jm0504149
Homo sapiens Aldehyde dehydrogenase Inhibition nan % 10.1021/jm501900s
Homo sapiens Aldehyde dehydrogenase 1A1 Activity nan None 10.1021/jm501900s
Homo sapiens Aldehyde dehydrogenase 1A1 Inhibition nan % 10.1021/jm501900s
Homo sapiens Aldehyde dehydrogenase 1A3 Inhibition nan % 10.1021/jm501900s
Homo sapiens Aldehyde dehydrogenase dimeric NADP-preferring Inhibition nan % 10.1021/jm501900s
Homo sapiens Aldehyde dehydrogenase X Inhibition nan % 10.1021/jm501900s
Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme IC50 5000.0 nM 10.1016/j.bmc.2009.12.012
Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme IC50 100000.0 nM 10.1016/j.ejmech.2017.11.068
Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Ki 82000.0 nM 10.1016/j.bmcl.2008.10.107
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Beta-secretase 1 Kd nan None 10.1016/j.ejmech.2017.06.020
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Brain adenylate cyclase 1 Kb 14000.0 nM 10.1021/jm00090a027
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 2511.9 nM None
Homo sapiens Caco-2 logPapp -4.4 None 10.1016/j.bmc.2011.03.011
Homo sapiens Caco-2 logPapp -4.35 None 10.1016/j.bmc.2009.08.022
Homo sapiens Caco-2 permeability nan None 10.1016/j.bmc.2011.03.011
Homo sapiens CAKI-1 GI50 22908.68 nM None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM GI50 100000.0 nM None
Homo sapiens Cerebroside-sulfatase Potency 37933.0 nM None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens COLO 205 GI50 100000.0 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Inhibition 30.0 % 10.1021/np020023m
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 Activity nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 10000.0 nM None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DU-145 GI50 100000.0 nM None
Homo sapiens EKVX GI50 100000.0 nM None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Geminin Potency 1258.9 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 11220.2 nM None
Homo sapiens HCC 2998 GI50 100000.0 nM None
Homo sapiens HCT-116 GI50 100000.0 nM None
Homo sapiens HCT-15 GI50 100000.0 nM None
Homo sapiens HEK293 CC50 nan None 10.1016/j.ejmech.2017.06.020
Homo sapiens HEK293 Potency 517.1 nM None
Homo sapiens Hepatocyte CL 0.65 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte CL 1.73 uL.min-1.(10^6cells)-1 10.1124/dmd.111.042309
Homo sapiens Hepatocyte logCL -0.1871 None 10.1016/j.ejmech.2008.07.027
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None 10.1016/j.ejmech.2018.10.057
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -54.3 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -5.34 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 281.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 3358.7 nM None
Homo sapiens HL-60 GI50 100000.0 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Absorption 98.0 % 10.1021/jm970530e
Homo sapiens Homo sapiens Activity 1.0 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens CL 0.6 mL.min-1.kg-1 10.1021/jm991030j
Homo sapiens Homo sapiens CL 0.8 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 0.86 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 0.86 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 1.29 mL.min-1.kg-1 10.1124/dmd.111.042309
Homo sapiens Homo sapiens Clearance 0.1 ul min-1 10.1021/jm991030j
Homo sapiens Homo sapiens CL_renal 0.09 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 98.8 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens Fa 1.0 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.96 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.99 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.97 None 10.1021/jm901371v
Homo sapiens Homo sapiens IC50 335000.0 nM 10.1021/jm00149a029
Homo sapiens Homo sapiens Vdss 0.51 L.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 0.57 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens HOP-62 GI50 100000.0 nM None
Homo sapiens HOP-92 GI50 100000.0 nM None
Homo sapiens Hs-578T GI50 100000.0 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 3162.3 nM None
Homo sapiens IGROV-1 GI50 100000.0 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Intestinal alkaline phosphatase IC50 5000.0 nM 10.1016/j.bmc.2009.12.012
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 20596.2 nM None
Homo sapiens K562 GI50 100000.0 nM None
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KM12 GI50 100000.0 nM None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver microsomes Activity 0.0 pmol 10.1021/tx300075j
Homo sapiens LOX IMVI GI50 100000.0 nM None
Homo sapiens Lymphoblastoid cell Potency 39810.7 nM None
Homo sapiens M14 GI50 100000.0 nM None
Homo sapiens Malme-3M GI50 100000.0 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 GI50 100000.0 nM None
Homo sapiens MDA-MB-231 GI50 100000.0 nM None
Homo sapiens MDA-N GI50 100000.0 nM None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MOLT-4 GI50 100000.0 nM None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens NCI/ADR-RES GI50 100000.0 nM None
Homo sapiens NCI-H226 GI50 100000.0 nM None
Homo sapiens NCI-H23 GI50 100000.0 nM None
Homo sapiens NCI-H322M GI50 100000.0 nM None
Homo sapiens NCI-H460 GI50 100000.0 nM None
Homo sapiens NCI-H522 GI50 100000.0 nM None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear receptor ROR-gamma Potency 42163.2 nM None
Homo sapiens OVCAR-3 GI50 100000.0 nM None
Homo sapiens OVCAR-5 GI50 100000.0 nM None
Homo sapiens OVCAR-8 GI50 100000.0 nM None
Homo sapiens P2X purinoceptor 3 IC50 nan None 10.1016/j.ejmech.2018.03.023
Homo sapiens Palmitoleoyl-protein carboxylesterase NOTUM Kd 6800000.0 nM 10.1021/acs.jmedchem.0c01974
Homo sapiens Palmitoleoyl-protein carboxylesterase NOTUM Kd 7000000.0 nM 10.1021/acs.jmedchem.1c00261
Homo sapiens PC-3 GI50 100000.0 nM None
Homo sapiens Phosphodiesterase 1 IC50 320000.0 nM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase 1 IC50 356000.0 nM 10.1021/jm970089s
Homo sapiens Phosphodiesterase 1C Inhibition 13.0 % 10.1021/jm00030a007
Homo sapiens Phosphodiesterase 2A IC50 210000.0 nM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase 3 IC50 240000.0 nM 10.1021/jm970089s
Homo sapiens Phosphodiesterase 3 IC50 360000.0 nM 10.1021/jm50001a001
Homo sapiens Phosphodiesterase 3 Inhibition 30.0 % 10.1021/jm00030a007
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4 ED50 37.0 umol.kg-1 10.1021/jm00096a008
Homo sapiens Phosphodiesterase 4 IC50 50000.0 nM 10.1021/acs.jmedchem.9b02170
Homo sapiens Phosphodiesterase 4 IC50 81000.0 nM 10.1021/jm970089s
Homo sapiens Phosphodiesterase 4 IC50 1780000.0 nM 10.1021/jm00379a004
Homo sapiens Phosphodiesterase 4 Inhibition 26.0 % 10.1021/jm00030a007
Homo sapiens Phosphodiesterase 4 Inhibition 27.0 % 10.1016/s0960-894x(98)00524-1
Homo sapiens Phosphodiesterase 4 Inhibition 39.0 % 10.1016/s0960-894x(98)00524-1
Homo sapiens Phosphodiesterase 4 Ki 56800.0 nM 10.1021/jm00062a010
Homo sapiens Phosphodiesterase 4 Ki 56800.0 nM 10.1021/jm00100a008
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4B IC50 200000.0 nM 10.1016/j.ejmech.2018.01.068
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Inhibition 13.0 % 10.1021/jm00030a007
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphodiesterase 7A IC50 200000.0 nM 10.1016/j.ejmech.2018.01.068
Homo sapiens Phospholipase A-2-activating protein IC50 5000.0 nM 10.1016/j.bmc.2009.12.012
Homo sapiens PI3-kinase p110-alpha subunit IC50 300000.0 nM 10.1039/C2MD20044A
Homo sapiens PI3-kinase p110-beta subunit IC50 800000.0 nM 10.1039/C2MD20044A
Homo sapiens PI3-kinase p110-delta subunit IC50 75000.0 nM 10.1039/C2MD20044A
Homo sapiens PI3-kinase p110-gamma subunit IC50 800000.0 nM 10.1039/C2MD20044A
Homo sapiens PI3-kinase p110-gamma subunit IC50 2904000.0 nM 10.1016/j.ejmech.2014.07.056
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Retinal dehydrogenase 2 Inhibition nan % 10.1021/jm501900s
Homo sapiens RPMI-8226 GI50 100000.0 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-268 GI50 100000.0 nM None
Homo sapiens SF-295 GI50 100000.0 nM None
Homo sapiens SF-539 GI50 100000.0 nM None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SK-MEL-2 GI50 100000.0 nM None
Homo sapiens SK-MEL-28 GI50 100000.0 nM None
Homo sapiens SK-MEL-5 GI50 100000.0 nM None
Homo sapiens SN12C GI50 100000.0 nM None
Homo sapiens SNB-19 GI50 100000.0 nM None
Homo sapiens SNB-75 GI50 91201.08 nM None
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 6.9 % 10.1021/jm00381a019
Homo sapiens Sodium channel alpha subunits; brain (Types I, II, III) Inhibition 7.0 % 10.1021/jm00381a019
Homo sapiens Solute carrier family 22 member 1 Inhibition -4.4 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 7 Activity nan None 10.1124/dmd.104.003301
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 0.8 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 90.11 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 2.5 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 72.46 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition -25.5 % 10.1021/jm300212s
Homo sapiens SR GI50 100000.0 nM None
Homo sapiens SW-620 GI50 100000.0 nM None
Homo sapiens T47D GI50 100000.0 nM None
Homo sapiens TAR DNA-binding protein 43 Potency 11220.2 nM None
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens TK-10 GI50 100000.0 nM None
Homo sapiens Transcriptional regulator ERG Potency 7079.5 nM None
Homo sapiens Transmembrane domain-containing protein TMIGD3 Ki 86400.0 nM 10.1039/C5MD00573F
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9441.1 nM None
Homo sapiens U-251 GI50 100000.0 nM None
Homo sapiens UACC-257 GI50 100000.0 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 1258.9 nM None
Homo sapiens UO-31 GI50 100000.0 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 1.07 % 10.6019/CHEMBL4513141
Leishmania amazonensis Leishmania amazonensis IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania donovani Leishmania donovani IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania infantum Leishmania infantum IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania major Leishmania major IC50 nan None 10.1016/j.bmc.2010.01.068
Leishmania mexicana Leishmania mexicana IC50 nan None 10.1016/j.bmc.2010.01.068
Mus musculus Adenosine A2b receptor Kb 16000.0 nM 10.1021/jm011093d
Mus musculus B16-F0 Activity 127.6 % 10.1016/j.bmc.2014.04.053
Mus musculus B16-F0 Activity 131.7 % 10.1016/j.bmc.2014.04.053
Mus musculus B16-F0 Activity 166.8 % 10.1016/j.bmc.2014.04.053
Mus musculus B16-F0 Activity 170.7 % 10.1016/j.bmc.2014.04.053
Mus musculus B16-F0 Activity 183.2 % 10.1016/j.bmc.2014.04.053
Mus musculus B16-F0 Activity 204.0 % 10.1016/j.bmc.2014.04.053
Mus musculus B16-F10 Activity 91.4 % 10.1016/j.bmc.2013.12.062
Mus musculus B16-F10 Activity 94.4 % 10.1016/j.bmc.2013.12.062
Mus musculus B16-F10 Activity 95.5 % 10.1016/j.bmc.2013.12.062
Mus musculus B16-F10 Activity 127.6 % 10.1016/j.bmc.2013.12.062
Mus musculus B16-F10 Activity 131.7 % 10.1016/j.bmc.2013.12.062
Mus musculus B16-F10 Activity 166.8 % 10.1016/j.bmc.2013.12.062
Mus musculus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus Acquisition time 16.2 s 10.1021/jm00069a009
Mus musculus Mus musculus Acquisition time 20.3 s 10.1021/jm00069a009
Mus musculus Mus musculus Acquisition time 30.8 s 10.1021/jm00069a009
Mus musculus Mus musculus Acquisition time 35.8 s 10.1021/jm00069a009
Mus musculus Mus musculus Activity 130.0 % 10.1021/jm00096a008
Mus musculus Mus musculus Activity 170.0 % 10.1021/jm00096a008
Mus musculus Mus musculus Activity 296.9 pmol/ml 10.1016/j.ejmech.2018.01.068
Mus musculus Mus musculus Activity nan None 10.1021/jm100490m
Mus musculus Mus musculus ED50 140.0 mg.kg-1 10.1021/jm00149a029
Mus musculus Mus musculus ED50 140.0 mg.kg-1 10.1021/jm00166a023
Mus musculus Mus musculus LD50 1900.0 umol.kg-1 10.1021/jm00096a008
Mus musculus Mus musculus Locomotor activity 5914.0 Counts 10.1021/jm00069a009
Mus musculus Mus musculus Locomotor activity 7682.0 Counts 10.1021/jm00069a009
Mus musculus Mus musculus Locomotor activity 11031.0 Counts 10.1021/jm00069a009
Mus musculus Mus musculus MLD 300.0 mg kg-1 10.1021/jm00100a009
Mus musculus Mus musculus permeability 0.48 umol cm2/hr 10.1016/j.bmcl.2006.03.061
Mus musculus Mus musculus Retention time 85.4 s 10.1021/jm00069a009
Mus musculus Mus musculus Retention time 103.8 s 10.1021/jm00069a009
Mus musculus Mus musculus Retention time 113.3 s 10.1021/jm00069a009
Mus musculus Mus musculus Retention time 165.5 s 10.1021/jm00069a009
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Skin permeability 1.02 umol/cm2/hr 10.1016/j.bmcl.2011.04.118
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2010.01.068
Pneumocystis carinii Pneumocystis carinii IC50 nan None 10.1016/j.bmc.2010.01.068
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 16.98 % 10.6019/CHEMBL4513141
Rattus norvegicus Adenosine A1 receptor Antagonism 56.2 % 10.1021/jm991051d
Rattus norvegicus Adenosine A1 receptor Enhancement 14.9 % 10.1021/jm991051d
Rattus norvegicus Adenosine A1 receptor IC50 10000.0 nM 10.1021/jm00400a022
Rattus norvegicus Adenosine A1 receptor IC50 19000.0 nM 10.1021/jm00030a007
Rattus norvegicus Adenosine A1 receptor IC50 20000.0 nM 10.1021/jm00384a016
Rattus norvegicus Adenosine A1 receptor IC50 28000.0 nM 10.1021/jm00376a027
Rattus norvegicus Adenosine A1 receptor IC50 14125375446227.55 nM 10.1021/jm00146a016
Rattus norvegicus Adenosine A1 receptor Kb 8700.0 nM 10.1021/jm011093d
Rattus norvegicus Adenosine A1 receptor Ki 700.0 nM 10.1021/jm00174a004
Rattus norvegicus Adenosine A1 receptor Ki 6920.0 nM 10.1021/jm0104318
Rattus norvegicus Adenosine A1 receptor Ki 7400.0 nM 10.1021/jm00118a032
Rattus norvegicus Adenosine A1 receptor Ki 8470.0 nM 10.1021/jm00069a009
Rattus norvegicus Adenosine A1 receptor Ki 8470.0 nM 10.1021/jm00083a018
Rattus norvegicus Adenosine A1 receptor Ki 8470.0 nM 10.1021/jm00090a027
Rattus norvegicus Adenosine A1 receptor Ki 8470.0 nM 10.1021/jm00094a022
Rattus norvegicus Adenosine A1 receptor Ki 8470.0 nM 10.1021/jm00128a031
Rattus norvegicus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm00046a022
Rattus norvegicus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm00081a001
Rattus norvegicus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm00130a004
Rattus norvegicus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm00168a027
Rattus norvegicus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm4011669
Rattus norvegicus Adenosine A1 receptor Ki 8500.0 nM 10.1021/jm900413e
Rattus norvegicus Adenosine A1 receptor Ki 8700.0 nM 10.1021/jm00126a014
Rattus norvegicus Adenosine A1 receptor Ki 9200.0 nM 10.1021/jm00107a046
Rattus norvegicus Adenosine A1 receptor Ki 9700.0 nM 10.1021/jm00094a022
Rattus norvegicus Adenosine A1 receptor Ki 13000.0 nM 10.1021/jm00090a027
Rattus norvegicus Adenosine A1 receptor Ki 13000.0 nM 10.1021/jm00126a014
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1016/j.bmc.2010.01.072
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1016/j.bmc.2013.09.044
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1016/j.ejmech.2019.111879
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00036a019
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00070a007
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00074a015
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00118a032
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00157a035
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00172a022
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm00382a018
Rattus norvegicus Adenosine A1 receptor Ki 14000.0 nM 10.1021/jm970515+
Rattus norvegicus Adenosine A1 receptor Ki 17000.0 nM 10.1021/jm970515+
Rattus norvegicus Adenosine A1 receptor Ki 26000.0 nM 10.1021/np9702704
Rattus norvegicus Adenosine A1 receptor PCY 0.7 None 10.1021/jm00384a016
Rattus norvegicus Adenosine A2a receptor Kb 13700.0 nM 10.1021/jm011093d
Rattus norvegicus Adenosine A2a receptor Ki 6700.0 nM 10.1021/jm0104318
Rattus norvegicus Adenosine A2a receptor Ki 8000.0 nM 10.1021/jm00070a007
Rattus norvegicus Adenosine A2a receptor Ki 9400.0 nM 10.1021/jm970515+
Rattus norvegicus Adenosine A2a receptor Ki 19000.0 nM 10.1021/jm970515+
Rattus norvegicus Adenosine A2a receptor Ki 22000.0 nM 10.1016/j.bmc.2010.01.072
Rattus norvegicus Adenosine A2a receptor Ki 22000.0 nM 10.1016/j.bmc.2013.09.044
Rattus norvegicus Adenosine A2a receptor Ki 22000.0 nM 10.1016/j.ejmech.2019.111879
Rattus norvegicus Adenosine A2a receptor Ki 22000.0 nM 10.1021/np9702704
Rattus norvegicus Adenosine A2a receptor Ki 25000.0 nM 10.1021/jm00046a022
Rattus norvegicus Adenosine A2a receptor Ki 25000.0 nM 10.1021/jm4011669
Rattus norvegicus Adenosine A2a receptor Ki 25000.0 nM 10.1021/jm900413e
Rattus norvegicus Adenosine A2b receptor Ki 15100.0 nM 10.1016/j.bmc.2010.01.072
Rattus norvegicus Adenosine A2b receptor Ki 15100.0 nM 10.1021/jm0104318
Rattus norvegicus Adenosine A2b receptor Ki 15100.0 nM 10.1021/jm900413e
Rattus norvegicus Adenosine A2 receptor IC50 10000.0 nM 10.1021/jm00400a022
Rattus norvegicus Adenosine A2 receptor Ki 1310.0 nM 10.1021/jm00174a004
Rattus norvegicus Adenosine A2 receptor Ki 4800.0 nM 10.1021/jm00118a032
Rattus norvegicus Adenosine A2 receptor Ki 16000.0 nM 10.1021/jm00069a009
Rattus norvegicus Adenosine A2 receptor Ki 16000.0 nM 10.1021/jm00083a018
Rattus norvegicus Adenosine A2 receptor Ki 16000.0 nM 10.1021/jm00090a027
Rattus norvegicus Adenosine A2 receptor Ki 16000.0 nM 10.1021/jm00094a022
Rattus norvegicus Adenosine A2 receptor Ki 16000.0 nM 10.1021/jm00105a072
Rattus norvegicus Adenosine A2 receptor Ki 17000.0 nM 10.1021/jm00126a014
Rattus norvegicus Adenosine A2 receptor Ki 17000.0 nM 10.1021/jm00172a022
Rattus norvegicus Adenosine A2 receptor Ki 19000.0 nM 10.1021/jm00036a019
Rattus norvegicus Adenosine A2 receptor Ki 22000.0 nM 10.1021/jm00074a015
Rattus norvegicus Adenosine A2 receptor Ki 25000.0 nM 10.1021/jm00107a046
Rattus norvegicus Adenosine A2 receptor Ki 25000.0 nM 10.1021/jm00130a004
Rattus norvegicus Adenosine A2 receptor Ki 25000.0 nM 10.1021/jm00172a022
Rattus norvegicus Adenosine A2 receptor Ki 25300.0 nM 10.1021/jm00083a018
Rattus norvegicus Adenosine A2 receptor Ki 25300.0 nM 10.1021/jm00090a027
Rattus norvegicus Adenosine A2 receptor Ki 25300.0 nM 10.1021/jm00094a022
Rattus norvegicus Adenosine A2 receptor Ki 25300.0 nM 10.1021/jm00128a031
Rattus norvegicus Adenosine A2 receptor Ratio 25000.0 nM 10.1021/jm00081a001
Rattus norvegicus Adenosine A3 receptor Inhibition 23.1 % 10.1021/jm00046a022
Rattus norvegicus Adenosine A3 receptor Ki 85000.0 nM 10.1016/j.bmc.2010.01.072
Rattus norvegicus Adenosine A3 receptor Ki 100000.0 nM 10.1016/j.ejmech.2019.111879
Rattus norvegicus Adenosine A3 receptor Ki 100000.0 nM 10.1021/jm900413e
Rattus norvegicus Adenosine receptor Ki 150.0 nM 10.1021/jm00345a001
Rattus norvegicus Adenosine receptor Ki 2000.0 nM 10.1021/jm00345a001
Rattus norvegicus Adenosine receptor Ki 4500.0 nM 10.1021/jm00345a001
Rattus norvegicus Adenosine receptor Ki 9000.0 nM 10.1021/jm00345a001
Rattus norvegicus Adenosine receptor Ki 20000.0 nM 10.1021/jm00345a001
Rattus norvegicus Adenosine receptor Ki 22000.0 nM 10.1021/jm00345a001
Rattus norvegicus Adenosine receptor A2a and A3 Ratio 4.0 None 10.1021/jm00046a022
Rattus norvegicus Adenosine receptors; A1 & A2 A1 selectivity 1.0 None 10.1021/jm00036a019
Rattus norvegicus Adenosine receptors; A1 & A2 Ki ratio 0.7 None 10.1021/jm00094a022
Rattus norvegicus Adenosine receptors; A1 & A2 Ratio 0.7 None 10.1021/jm00083a018
Rattus norvegicus Adenosine receptors; A1 & A2 Ratio 2.7 None 10.1021/jm00107a046
Rattus norvegicus Adenosine receptors; A1 & A2 Ratio 2.99 None 10.1021/jm00128a031
Rattus norvegicus Adenosine receptors; A1 & A2 Ratio 3.0 None 10.1021/jm00081a001
Rattus norvegicus Adenosine receptors; A1 & A2a Selectivity ratio 1.8 None 10.1021/jm970515+
Rattus norvegicus Adenosine receptors; A1 & A3 Ratio 10.0 None 10.1021/jm00046a022
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Inositol monophosphatase 1 Potency 7943.3 nM None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Peripheral myelin protein 22 Potency 2.9 nM None
Rattus norvegicus Phosphodiesterase 4 Ki 530000.0 nM 10.1021/jm00185a008
Rattus norvegicus Plasma Fu 0.61 None 10.1021/jm901371v
Rattus norvegicus Plasma logFu 0.46 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Rattus norvegicus Acquisition time 10.6 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Acquisition time 10.8 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Acquisition time 11.1 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Acquisition time 12.2 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Activity 3.75 None 10.1021/jm00118a008
Rattus norvegicus Rattus norvegicus ALB 29000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 30000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 31000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 32000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 33000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 34000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALB 40300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALBGLOB 1.0 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.1 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.2 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALBGLOB 1.3 None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 320.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 334.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 334.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 345.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 349.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 356.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 1031.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1071.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1103.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1140.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1241.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1256.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1278.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1300.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1309.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1323.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1338.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1398.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1401.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1402.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1415.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1423.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1434.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1444.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1474.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1497.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1498.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1532.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1552.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1566.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1574.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1599.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1615.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1618.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1662.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1736.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1800.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALP 1988.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 35.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 37.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 38.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 38.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 38.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 39.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 40.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 41.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 42.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 43.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 44.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 45.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 46.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 48.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 49.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 50.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 51.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 55.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 56.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 58.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus ALT 59.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus APTT 21.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 21.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 22.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 23.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 24.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 25.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 26.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus APTT 27.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 64.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 67.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 68.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 69.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 69.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 70.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 70.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 71.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 73.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 75.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 76.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 77.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 79.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 80.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 80.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 82.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 85.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 85.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 86.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 86.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 87.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 91.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 92.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 92.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 93.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 111.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus AST 113.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 113.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILDIR 0.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILDIR 0.06 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.04 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.06 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.075 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.08 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.1 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.14 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.16 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.18 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.2 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.22 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.24 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.25 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 0.26 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Blood pressure 13.5 mmHg 10.1021/jm00138a002
Rattus norvegicus Rattus norvegicus Blood pressure 31.6 mmHg 10.1021/jm00138a002
Rattus norvegicus Rattus norvegicus Blood pressure 31.9 mmHg 10.1021/jm00138a002
Rattus norvegicus Rattus norvegicus BUN 98.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 116.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 120.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 123.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 126.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 130.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 138.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 144.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 148.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 150.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 152.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 154.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 155.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 156.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 162.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 163.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 164.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 165.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 165.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 166.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 176.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 178.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 182.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 186.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 192.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus BUN 200.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 100.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 101.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 102.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 103.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 104.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 105.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 106.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 107.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 108.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 109.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 111.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CALCIUM 112.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHLORIDE 99.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 106.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 650.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 660.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 668.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 678.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 694.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 700.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 702.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 705.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 712.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 714.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 720.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 728.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 732.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 736.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 738.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 740.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 750.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 760.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 772.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 773.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 774.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 782.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 785.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 790.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 792.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 804.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 806.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 824.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 850.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CHOL 893.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 940.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 215.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 255.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 272.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 381.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 788.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 1028.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cl 104.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 104.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 104.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 105.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.6 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 106.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 107.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.0 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.2 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.4 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Cl 108.8 meq/L 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CL 2.2 mL.min-1.kg-1 10.1021/jm991030j
Rattus norvegicus Rattus norvegicus Clearance 0.2 ul min-1 10.1021/jm991030j
Rattus norvegicus Rattus norvegicus CO2 23330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 25330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26500000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cr 5.32 mg dl-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus CREAT 1.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus CREAT 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Decrease 15.0 % 10.1021/jm50001a019
Rattus norvegicus Rattus norvegicus Decrease 45.0 % 10.1021/jm50001a019
Rattus norvegicus Rattus norvegicus EC50 425000.0 nM 10.1016/j.ejmech.2020.112652
Rattus norvegicus Rattus norvegicus ED50 0.9 mM 10.1021/jm00096a008
Rattus norvegicus Rattus norvegicus ED50 0.9 nM 10.1021/jm00368a018
Rattus norvegicus Rattus norvegicus ED50 0.92 mM 10.1021/jm00096a008
Rattus norvegicus Rattus norvegicus ED50 7.9 mg.kg-1 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus ED50 11.7 mg.kg-1 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus ED50 19.2 mg.kg-1 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus ED50 22.4 mg.kg-1 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus ED50 22.4 mg.kg-1 10.1021/jm00349a020
Rattus norvegicus Rattus norvegicus ED50 41.5 mg.kg-1 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus ED50 41.5 mg.kg-1 10.1021/jm00349a020
Rattus norvegicus Rattus norvegicus ED50 47.2 mg.kg-1 10.1021/jm00361a022
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 50.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 162.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 168.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 319.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 0.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus EOSLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus FIBRINO 2780.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2898.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2912.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2930.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2970.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2982.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 2994.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3006.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3028.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3030.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3034.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3054.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3060.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3102.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3126.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3144.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3154.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3168.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3246.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3292.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3302.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3332.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3334.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3358.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3368.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3370.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3490.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3498.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3540.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 3704.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus FIBRINO 4385.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 1.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GGT 2.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1383.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1430.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1443.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1476.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1513.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1618.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1652.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1704.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1730.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1755.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1776.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1782.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1788.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1810.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1818.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1838.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1844.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1854.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1860.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1864.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1865.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1880.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1882.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1898.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1904.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1910.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1912.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1922.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1934.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1936.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1948.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 1954.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2028.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2038.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2046.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2066.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus GLUC 2122.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 34.43 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.77 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 38.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 38.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 38.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 39.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 40.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 41.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 42.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 43.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 44.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 44.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 45.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HCT 46.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 123000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 126000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 130300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 131000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 132000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 133000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 134000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 135000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 136000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 139000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 139700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 144000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 145000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 146000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 147300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 147700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 148000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 150000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 154000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 155000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 158000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus HGB 161000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus IC50 2500000.0 nM 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 0.0 % 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 2.0 % 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Inhibition 5.0 % 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Inhibition 13.0 % 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 25.1 % 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 42.4 % 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 51.9 % 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 52.5 % 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Inhibition 66.0 % 10.1021/jm00118a008
Rattus norvegicus Rattus norvegicus K+ excretion 1.16 ml 6hr-1 100g-1 10.1021/jm00105a072
Rattus norvegicus Rattus norvegicus LDH 132.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 134.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 137.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 137.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 140.5 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 140.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 146.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 157.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 159.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 167.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 168.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 168.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 168.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 174.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 175.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 175.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 178.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 179.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 180.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 180.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 182.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 182.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 183.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 184.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 184.4 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 184.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 198.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 202.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 212.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 212.6 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 215.8 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 221.0 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 244.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 253.2 IU.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LDH 332.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 487.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 644.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 1127.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12014.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13284.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13539.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13654.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14175.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14520.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 58.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 67.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 67.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 68.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 69.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 70.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 73.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 75.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 76.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 77.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 78.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 79.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 80.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 82.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 82.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 83.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 83.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus LYMLE 84.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 87.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 18.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 18.9 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.8 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 19.9 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.2 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.3 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.4 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.5 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.6 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.7 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.8 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 20.9 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.0 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.1 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 21.2 pg 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCH 23.7 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.42 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.7 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.77 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 32.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 32.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 33.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.1 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 34.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCHC 378700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 390000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 391300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 397300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 400000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 54.4 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 54.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 57.3 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 57.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 59.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 59.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 59.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 60.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 60.7 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 60.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.3 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.4 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 61.97 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.05 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.3 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.5 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.55 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.57 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.8 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 62.9 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.2 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MCV 63.2 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.0 fL 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Mean arterial blood pressure 1.0 None 10.1021/jm00138a002
Rattus norvegicus Rattus norvegicus Mean arterial blood pressure 2.34 None 10.1021/jm00138a002
Rattus norvegicus Rattus norvegicus Mean arterial blood pressure 2.36 None 10.1021/jm00138a002
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 120.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 121.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 161.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 177.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 303.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 1.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 1.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 2.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 3.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus MONOLE 4.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Na 0.09 m equiv 6hr-1 100g-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Na 0.201 m equiv 6hr-1 100g-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Na 0.417 m equiv 6hr-1 100g-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Na+ excretion 1.52 ml 6hr-1 100g-1 10.1021/jm00105a072
Rattus norvegicus Rattus norvegicus Na+/K+ 1.06 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Na+/K+ 1.08 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Na+/K+ 1.31 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus NEUTLE 8.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 12.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 13.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 13.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 13.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 13.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 14.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 15.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 16.8 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 17.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 18.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 19.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 22.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 24.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 26.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 26.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 28.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 28.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTLE 35.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus NEUTSG 1223.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1511.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1696.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1804.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2078.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 2116.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Permeability 22.35 cm (10e3*hr)-1 10.1021/jm00126a038
Rattus norvegicus Rattus norvegicus PHOS 62.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 65.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 68.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 71.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 72.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 73.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 74.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 75.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 77.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 78.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 80.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 82.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 83.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 84.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 85.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 87.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 88.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 92.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 93.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOS 100.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 115.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 118.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 118.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 119.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 121.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOSLPD 1098.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1200.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1208.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1216.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1228.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1246.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1256.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1260.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1266.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1270.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1288.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1298.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1326.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1328.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1335.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1346.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1354.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1358.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1374.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1376.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1402.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1406.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1410.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1434.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1452.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1458.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1492.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1500.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1516.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1522.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PHOSLPD 1566.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 917000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 988000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 995000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1023000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1087000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1092000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1097000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1109000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1118000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1120000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1135000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1146000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1147000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1150000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1158000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1170000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1177000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1187000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1190000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1195000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1198000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1203000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1205000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1211000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1229000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1231000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1235000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1237000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1241000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1258000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1281170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1299000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1312170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1322000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1342000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PLAT 1354330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1468000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.5 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.7 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 3.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.1 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.3 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 4.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus POTASSIUM 5.95 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.43 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.76 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.78 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.88 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 53000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 54000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 55000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 57000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 58500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 61700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PROT 62200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 65000.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.4 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.5 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.8 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 15.9 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.0 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.1 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.2 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.3 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.6 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus PT 16.7 s 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 5500000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5700000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5780000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5950000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6060000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6142000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6226000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6230000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6254000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6268000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6302000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6322000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6324000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6348000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6368000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6442000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6496000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6558000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6570000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6572000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6620000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6642000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6646000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6666000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6704000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6768000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6790000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 6918000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7064000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7115000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7206000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7248000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7678000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7830000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 7980000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 8100000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBC 8208000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Relative potency 1.0 None 10.1021/jm00185a008
Rattus norvegicus Rattus norvegicus Retention time 10.9 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Retention time 14.6 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Retention time 29.0 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Retention time 31.2 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus Retention time 45.8 s 10.1021/jm00069a009
Rattus norvegicus Rattus norvegicus RETIRBC 2.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 2.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 3.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 3.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.7 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 4.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 5.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 6.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.0 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.2 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.3 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.5 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.6 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 7.9 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus RETIRBC 8.4 % 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 136.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 139.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 140.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 141.8 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 142.6 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.0 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.2 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.4 mEq.L-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus SODIUM 143.77 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.43 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.95 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 149.9 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T/C 1.03 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus T/C 1.14 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus T/C 1.34 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus T/C 1.42 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus T/C 1.52 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus T/C 2.16 None 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus TERMBW 210.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 211.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 211.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 212.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 212.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 213.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 213.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 215.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 215.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 215.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 216.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 221.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 224.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 225.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 228.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 242.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 242.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 247.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 254.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 265.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 271.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 278.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 288.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 313.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 324.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 330.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 357.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 371.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 378.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TERMBW 384.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus TRIG 200.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 222.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 238.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 306.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 336.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 360.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 378.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 388.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 454.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 482.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 492.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 514.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 518.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 528.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 606.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 642.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 656.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 750.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 836.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 868.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 900.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 924.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 944.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 962.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 970.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 974.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 976.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1002.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1062.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1354.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus TRIG 1456.0 ug.mL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus UN 174.0 mg dl-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus URATE 13.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 18.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Urine volume 0.71 ml 6hr-1 100g-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Urine volume 1.18 ml 6hr-1 100g-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Urine volume 1.22 ml 6hr-1 100g-1 10.1021/jm00094a022
Rattus norvegicus Rattus norvegicus Urine volume 1.42 ml 6hr-1 100g-1 10.1021/jm00105a072
Rattus norvegicus Rattus norvegicus WBC 5180.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 5890.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7270.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7410.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7580.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7730.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 7960.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8390.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 8960.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9700.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9780.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 9940.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10120.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10260.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10360.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10480.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10740.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 10900.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11000.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11250.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11330.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11380.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11690.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 11930.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12190.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12340.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12520.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12600.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 12830.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 13310.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 13820.0 cells.uL-1 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WBC 14100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16270.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WEIGHT 0.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 1.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 2.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 3.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 8.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.0 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 9.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.1 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 10.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.6 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 11.7 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 12.2 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 12.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 12.9 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 13.8 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 14.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.4 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 15.5 g 10.6019/CHEMBL3885861
Rattus norvegicus Rattus norvegicus WEIGHT 16.3 g 10.6019/CHEMBL3885861
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Small intestine log%Abs 1.46 None 10.1021/jm00211a010
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 14125.4 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 7079.5 nM None
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity nan None 10.1016/j.bmc.2013.03.043
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 37.24 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.2338 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.3 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.2 % 10.6019/CHEMBL4495565
Staphylococcus aureus Staphylococcus aureus Inhibition -24.23 % 10.6019/CHEMBL4513141
Toxoplasma gondii Toxoplasma gondii IC50 nan None 10.1016/j.bmc.2010.01.068
Trichomonas vaginalis Trichomonas vaginalis IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei 6-phospho-1-fructokinase Potency 756.9 nM None
Trypanosoma brucei Trypanosoma brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 nan None 10.1016/j.bmc.2010.01.068
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1016/j.bmc.2010.01.068
Vibrio harveyi Vibrio harveyi Activity 15.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 42.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 54.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 64.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 77.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 114.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 159.0 None 10.1016/j.bmc.2007.05.025
Vibrio harveyi Vibrio harveyi Activity 176.0 None 10.1016/j.bmc.2007.05.025
None ADMET Activity 91.4 % 10.1016/j.bmc.2014.04.053
None ADMET Activity 94.4 % 10.1016/j.bmc.2014.04.053
None ADMET Activity 95.5 % 10.1016/j.bmc.2014.04.053
None ADMET CL 0.86 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 2.6 mL.min-1.kg-1 10.1124/dmd.111.042309
None ADMET CL 3.0 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 4.79 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 5.75 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET delta logD -0.12 None 10.1021/jm9505932
None ADMET delta logD 0.02 None 10.1021/jm0000564
None ADMET F 80.0 % 10.1021/jm0000564
None ADMET Fu 0.46 None 10.1021/jm030408h
None ADMET Fu 0.53 None 10.1124/dmd.111.042309
None ADMET Kp 0.1 10^-6 cm/s 10.1016/j.bmc.2022.117146
None ADMET Kp 1.04 10^-6 cm/s 10.1016/j.bmc.2022.117146
None ADMET logPapp -4.35 None 10.1124/dmd.111.041665
None ADMET LogP app -5.58 None 10.1016/j.bmc.2007.03.040
None ADMET LogP app -5.31 None 10.1016/j.bmc.2007.03.040
None ADMET log Pe -7.3 None 10.1016/j.bmc.2015.01.045
None ADMET log Pe -7.3 None 10.1016/j.bmc.2015.03.051
None ADMET log Pe -6.4 None 10.1016/j.ejmech.2020.112282
None ADMET log Pe -6.35 None 10.1016/j.ejmech.2020.113059
None ADMET log Pe -6.0 None 10.1016/j.ejmech.2016.03.023
None ADMET logPeff -6.9 None 10.1016/j.bmc.2016.11.032
None ADMET logPeff -6.3 None 10.1016/j.ejmech.2016.08.016
None ADMET logP(lung) -0.15 None 10.1016/j.ejmech.2007.04.002
None ADMET MRT 9.9 hr 10.1124/dmd.108.020479
None ADMET Papp 0.56 10'6cm/s 10.1016/j.ejmech.2009.03.039
None ADMET Papp 1.4 ucm/s 10.1021/acs.jmedchem.0c01477
None ADMET Papp 2.61 10^-6 cm/s 10.1016/j.bmc.2007.03.040
None ADMET Peff 0.1 10'-6 cm/s 10.1016/j.bmc.2015.01.005
None ADMET Peff 0.1 10^-6 cm/s 10.1016/j.bmc.2022.116878
None ADMET Peff 0.12 10'-6 cm/s 10.1016/j.bmc.2015.01.005
None ADMET Peff 0.12 10^-6 cm/s 10.1016/j.bmc.2022.116878
None ADMET Peff 0.13 ucm/s 10.1016/j.bmcl.2016.03.086
None ADMET Peff 0.26 10'-6 cm/s 10.1016/j.ejmech.2014.09.081
None ADMET Peff 1.1 10'-6 cm/s 10.1016/j.bmcl.2016.05.087
None ADMET permeability 0.09 ucm/s 10.1021/jm301630s
None ADMET permeability 0.1 10'-6 cm/s 10.1016/j.bmc.2016.11.048
None ADMET permeability 0.1 10^-6 cm/s 10.1016/j.ejmech.2020.112475
None ADMET permeability 0.1 10^-6 cm/s 10.1016/j.ejmech.2021.113154
None ADMET permeability 0.1 ucm/s 10.1016/j.bmc.2013.09.050
None ADMET permeability 0.1 ucm/s 10.1016/j.bmc.2016.04.012
None ADMET permeability 0.12 10'-6 cm/s 10.1016/j.bmc.2016.11.048
None ADMET permeability 0.12 10^-6 cm/s 10.1021/acs.jmedchem.0c02145
None ADMET permeability 0.12 ucm/s 10.1016/j.bmc.2016.04.012
None ADMET permeability 0.12 ucm/s 10.1021/jm301630s
None ADMET permeability 0.17 ucm/s 10.1016/j.bmc.2016.12.013
None ADMET permeability 0.26 ucm/s 10.1016/j.bmc.2013.09.050
None ADMET permeability 0.27 10^-6 cm/s 10.1021/acs.jmedchem.2c00283
None ADMET permeability 0.3 10^-6 cm/s 10.1021/acsmedchemlett.1c00326
None ADMET permeability 0.32 ucm/s 10.1021/jm501203v
None ADMET permeability 0.69 10^-6 cm/s 10.1016/j.ejmech.2020.112475
None ADMET permeability 0.69 10^-6 cm/s 10.1016/j.ejmech.2022.114825
None ADMET permeability 0.83 10^-6 cm/s 10.1016/j.ejmech.2021.113154
None ADMET permeability 1.07 10'-6 cm/s 10.1016/j.ejmech.2016.09.078
None ADMET permeability 4.7 nm/s 10.1016/j.ejmech.2020.112668
None ADMET permeability 5.4 10'6cm/s 10.1016/j.bmcl.2009.06.091
None ADMET PPB 14.81 % 10.6019/CHEMBL3301361
None ADMET PPB 43.14 % 10.6019/CHEMBL3301361
None ADMET PPB 43.7 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.7 None 10.1021/jm00105a072
None ADMET Solubility 28.0 None 10.1021/jm9904708
None ADMET Solubility 44400000.0 nM 10.1021/jm011093d
None ADMET T1/2 7.2 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.51 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 0.57 L.kg-1 10.1021/jm030408h
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None NON-PROTEIN TARGET EC50 144000.0 nM 10.1016/j.ejmech.2014.03.029
None NON-PROTEIN TARGET ED50 2.09 mmol/L 10.1016/j.ejmech.2013.12.024
None NON-PROTEIN TARGET Emax 100.0 % 10.1016/j.ejmech.2014.03.029
None NON-PROTEIN TARGET Fu 0.61 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Fu 0.989 None 10.1124/dmd.111.042309
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 55.6 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 19900.0 nM 10.1016/j.ejmech.2013.12.032
None NON-PROTEIN TARGET IC50 309000.0 nM 10.1021/jm00166a023
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.01.068
None NON-PROTEIN TARGET Inhibition 50.0 % 10.1021/jm00190a003
None NON-PROTEIN TARGET Peff 0.12 ucm/s 10.1016/j.ejmech.2015.02.055
None NON-PROTEIN TARGET Peff 0.14 ucm/s 10.1016/j.ejmech.2015.02.055
None NON-PROTEIN TARGET Potency 1.1 nM None
None NON-PROTEIN TARGET Potency 5.3 nM None
None NON-PROTEIN TARGET Potency 53.0 nM None
None NON-PROTEIN TARGET Selectivity 0.9 None 10.1021/jm00062a010
None NON-PROTEIN TARGET Selectivity 2.2 None 10.1021/jm00062a010
None No relevant target Activity 94.49 % 10.1021/acs.jmedchem.9b01963
None No relevant target CHI 18.19 None 10.1016/j.ejmech.2019.111770
None No relevant target delta Log P 1.53 None 10.1021/jm9505932
None No relevant target Kd 400.0 nM 10.1021/jm030650o
None No relevant target LogD -5.0 None 10.1021/jm500942v
None No relevant target LogD -0.78 None 10.1021/jm00211a010
None No relevant target LogD -0.02 None 10.1021/jf102525e
None No relevant target LogD -0.02 None 10.1021/jm0000564
None No relevant target LogD -0.02 None 10.1021/jm970530e
None No relevant target LogD -0.02 None 10.1124/dmd.111.041665
None No relevant target LogD7.4 -0.09 None 10.6019/CHEMBL3301361
None No relevant target log K -0.51 None 10.1016/j.bmcl.2006.03.061
None No relevant target LogP -0.78 None 10.1021/jm00211a010
None No relevant target LogP -0.05 None 10.1016/j.bmcl.2005.04.064
None No relevant target LogP -0.02 None 10.1016/j.bmc.2007.03.040
None No relevant target LogP -0.02 None 10.1016/j.bmcl.2021.128318
None No relevant target LogP -0.02 None 10.1021/jf102525e
None No relevant target logPapp -5.31 None 10.1021/jf102525e
None No relevant target log Pe -6.0 None 10.1016/j.ejmech.2017.01.011
None No relevant target logPeff -6.71 None 10.1016/j.ejmech.2018.07.033
None No relevant target logPeff -6.23 None 10.1016/j.ejmech.2017.01.011
None No relevant target log(permeability) -6.29 None 10.1016/j.ejmech.2018.11.009
None No relevant target Log PNalk -1.7 None 10.1021/jm048980b
None No relevant target Log S -1.39 None 10.1016/s0960-894x(00)00172-4
None No relevant target Peff 0.06 10'-6 cm/s 10.1016/j.ejmech.2018.03.023
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.bmc.2017.03.070
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.bmc.2018.02.037
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.bmcl.2017.09.055
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.bmcl.2017.09.057
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.bmcl.2018.04.043
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.bmcl.2019.126625
None No relevant target Peff 0.1 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Peff 0.1 ucm/s 10.1016/j.bmc.2018.11.015
None No relevant target Peff 0.12 10'-6 cm/s 10.1016/j.bmc.2018.01.030
None No relevant target Peff 0.12 10'-6 cm/s 10.1016/j.bmc.2018.02.037
None No relevant target Peff 0.12 10'-6 cm/s 10.1016/j.bmcl.2018.04.043
None No relevant target Peff 0.12 10'-6 cm/s 10.1016/j.bmcl.2019.126625
None No relevant target Peff 0.12 10'-6 cm/s 10.1016/j.ejmech.2017.02.039
None No relevant target Peff 0.12 10'-6 cm/s 10.1016/j.ejmech.2019.06.026
None No relevant target Peff 0.12 ucm/s 10.1016/j.bmc.2017.02.027
None No relevant target Peff 0.12 ucm/s 10.1016/j.bmc.2018.11.015
None No relevant target Peff 0.12 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 0.12 ucm/s 10.1021/acs.jmedchem.7b01356
None No relevant target Peff 0.15 ucm/s 10.1021/acs.jmedchem.7b01356
None No relevant target Peff 0.17 10'-6 cm/s 10.1016/j.bmc.2018.01.030
None No relevant target Peff 0.26 10'-6 cm/s 10.1016/j.ejmech.2018.12.013
None No relevant target Peff 0.26 ucm/s 10.1016/j.ejmech.2018.10.057
None No relevant target Peff 0.29 10'-6 cm/s 10.1016/j.ejmech.2016.12.057
None No relevant target Peff 0.4 10'-6 cm/s 10.1016/j.ejmech.2017.12.084
None No relevant target Peff 0.51 10'-6 cm/s 10.1016/j.ejmech.2018.11.009
None No relevant target Peff 0.59 ucm/s 10.1016/j.ejmech.2017.01.011
None No relevant target Peff 6.85 nm/s 10.1021/acs.jmedchem.9b01963
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.bmc.2019.01.040
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.ejmech.2016.12.009
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.ejmech.2017.02.039
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.ejmech.2017.02.042
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.ejmech.2019.06.026
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.ejmech.2019.07.021
None No relevant target permeability 0.1 10'-6 cm/s 10.1016/j.ejmech.2019.111737
None No relevant target permeability 0.1 ucm/s 10.1016/j.bmcl.2017.01.050
None No relevant target permeability 0.12 10'-6 cm/s 10.1016/j.bmc.2019.01.040
None No relevant target permeability 0.12 10'-6 cm/s 10.1016/j.ejmech.2016.12.009
None No relevant target permeability 0.12 10'-6 cm/s 10.1016/j.ejmech.2019.111737
None No relevant target permeability 0.12 ucm/s 10.1016/j.bmcl.2017.01.050
None No relevant target permeability 0.13 ucm/s 10.1016/j.ejmech.2017.06.020
None No relevant target permeability 0.17 ucm/s 10.1016/j.bmc.2017.02.027
None No relevant target permeability 1.1 10'-6 cm/s 10.1016/j.ejmech.2017.07.058
None No relevant target permeability 8.48 10'-8cm/s 10.1016/j.bmc.2019.03.017
None No relevant target pKa 0.0 None 10.1021/jf102525e
None No relevant target pKa 4.6 None 10.1021/jm00211a010
None No relevant target pKa 8.8 None 10.1021/jm0000564
None No relevant target pKa 8.8 None 10.1124/dmd.111.042309
None No relevant target pKa nan None 10.1021/jm030408h
None No relevant target pKa_A1 8.51 None 10.6019/CHEMBL3301361
None No relevant target Retention_time 3.4 min 10.1016/j.ejmech.2015.02.055
None No relevant target Retention_time 7.31 min 10.1016/j.ejmech.2019.111770
None No relevant target Rm 0.61 None 10.1016/j.bmcl.2021.128318
None No relevant target Solubility 340000.0 nM 10.1016/j.bmcl.2006.03.061
None No relevant target Solubility 46000000.0 nM 10.1016/j.bmcl.2006.03.061
None Nucleic Acid K ass 157.0 M-1 10.1021/jm9904708
None Unchecked Ac50 22.39 uM None
None Unchecked AC50 22387.2 nM None
None Unchecked Activity 5.0 % 10.1021/jm00196a008
None Unchecked Activity 106.0 % 10.1021/jm980469t
None Unchecked Broncho selectivity 2.2 None 10.1021/jm00100a008
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 940.0 nM 10.1021/jm00174a004
None Unchecked IC50 85000.0 nM 10.1021/jm00346a017
None Unchecked IC50 90000.0 nM 10.1021/jm00345a010
None Unchecked IC50 100000.0 nM 10.1021/jm00140a008
None Unchecked IC50 190000.0 nM 10.1021/jm00140a008
None Unchecked IC50 190000.0 nM 10.1021/jm00345a010
None Unchecked IC50 210000.0 nM 10.1021/jm00345a010
None Unchecked IC50 286000.0 nM 10.1021/jm00143a004
None Unchecked IC50 300000.0 nM 10.1016/j.bmcl.2009.11.017
None Unchecked IC50 400000.0 nM 10.1016/j.bmcl.2009.11.017
None Unchecked IC50 412000.0 nM 10.1021/jm00143a004
None Unchecked IC50 430000.0 nM 10.1016/j.bmcl.2009.11.017
None Unchecked IC50 515000.0 nM 10.1021/jm00196a008
None Unchecked IC50 550000.0 nM 10.1016/j.bmcl.2009.11.017
None Unchecked IC50 1475000.0 nM 10.1021/jm00196a008
None Unchecked IC50 nan None None
None Unchecked Inhibition 2.3 % 10.1016/j.ejmech.2018.10.027
None Unchecked Inhibition 39.0 % 10.1021/jm800582j
None Unchecked Inhibition 51.0 % 10.1021/jm00190a003
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Kb 4800.0 nM 10.1021/jm00083a018
None Unchecked Kb 5700.0 nM 10.1021/jm00083a018
None Unchecked Ki 21000.0 nM 10.1016/j.bmc.2008.04.039
None Unchecked Ki 21000.0 nM 10.1021/jm8014876
None Unchecked Ki 77000.0 nM 10.1021/jm00345a010
None Unchecked Ki 110000.0 nM 10.1021/jm00346a017
None Unchecked Ki 150000.0 nM 10.1021/jm00345a010
None Unchecked Ki 180000.0 nM 10.1021/jm00345a010
None Unchecked Ki 180000.0 nM 10.1021/jm00346a017
None Unchecked Ki 565000.0 nM 10.1021/np9702704
None Unchecked Ki 1150000.0 nM 10.1021/jm00185a008
None Unchecked Ki nan None None
None Unchecked Ki ratio 1.4 None 10.1021/jm00090a027
None Unchecked Potency 1995.3 nM None
None Unchecked Potency 6513.1 nM None
None Unchecked Potency 18356.4 nM None
None Unchecked Potentiation 95.3 % 10.1021/jm980469t
None Unchecked Ratio 0.44 None 10.1021/jm0104318
None Unchecked Ratio 0.46 None 10.1021/jm0104318
None Unchecked Ratio 1.0 None 10.1021/jm00382a018
None Unchecked Ratio 2.6 None 10.1021/jm00185a008
None Unchecked Ratio 3.0 None 10.1021/jm00044a018
None Unchecked Ratio 3.0 None 10.1021/jm00130a004
None Unchecked Relative potency 1.0 None 10.1021/jm00138a002
None Unchecked Relative potency 1.0 None 10.1021/jm00143a004
None Unchecked Selectivity ratio 1.0 None 10.1021/jm00157a035

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT000489 *C.Cn1c(=O)[nH]c(=O)c2[nH]cnc21>>Cn1c(=O)c2[nH]cnc2n(C)c1=O MNXR176078
AKRT000490 *C.Cn1c(=O)c2[nH]cnc2n(C)c1=O>>Cn1c(=O)c2c(ncn2C)n(C)c1=O MNXR176077
AKRT014609 C[SAH].Cn1c(=O)[nH]c(=O)c2[nH]cnc21>>Cn1c(=O)c2[nH]cnc2n(C)c1=O enzymemap_26048
AKRT014611 C[SAH].Cn1c(=O)[nH]c(=O)c2nc[nH]c21>>Cn1c(=O)c2nc[nH]c2n(C)c1=O enzymemap_26048
AKRT014612 C[SAH].Cn1c(=O)[nH]c2nc[nH]c2c1=O>>Cn1c(=O)c2[nH]cnc2n(C)c1=O enzymemap_26047
AKRT015512 Cn1c(=O)c2[nH]cnc2n(C)c1=O>>C=O RXN-13108
AKRT015513 Cn1c(=O)c2[nH]cnc2n(C)c1=O>>Cn1c(=O)[nH]c(=O)c2[nH]cnc21 RXN-13108
AKRT015514 Cn1c(=O)c2[nH]cnc2n(C)c1=O>>Cn1c(=O)[nH]c2nc[nH]c2c1=O RXN-13110
AKRT015515 Cn1c(=O)c2[nH]cnc2n(C)c1=O>>Cn1c(=O)c2[nH]c(=O)[nH]c2n(C)c1=O RXN-13113
AKRT015522 Cn1c(=O)c2c(ncn2C)n(C)c1=O>>Cn1c(=O)c2[nH]cnc2n(C)c1=O RXN-22517