1-Amino-4-phenyl-2,7-naphthyridine
AlkaPlorer ID: AK005620
Synonym: 4-Phenyl-2,7-naphthyridin-1-amine, Lophocladine B
IUPAC Name: 4-phenyl-2,7-naphthyridin-1-amine
Structure
SMILES: N=C1NC=C(C2=CC=CC=C2)C2=C1C=NC=C2
InChI: InChI=1S/C14H11N3/c15-14-13-8-16-7-6-11(13)12(9-17-14)10-4-2-1-3-5-10/h1-9H,(H2,15,17)
InChIKey: UGLZUYWXOHMUSU-UHFFFAOYSA-N
Reference
Lophocladines, Bioactive Alkaloids from the Red Alga <i>Lophocladia</i> sp.
PubChem CID: 11665726
CAS: 887705-28-4
LOTUS: LTS0021828
SuperNatural Ⅲ: SN0369777
NPASS: NPC101165
COCONUT: CNP0165415
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Lophocladia | Rhodomelaceae | Ceramiales | Florideophyceae | Rhodophyta | None | Eukaryota |
Properties Information
Molecule Weight: 221.263
TPSA？: 52.53
MolLogP？: 2.7093700000000007
Number of H-Donors: 2
Number of H-Acceptors: 2
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | MDA-MB-435 | Activity | 8.0 | % | 10.1021/np050519e |
| Homo sapiens | MDA-MB-435 | Activity | 19.8 | % | 10.1021/np050519e |
| Homo sapiens | MDA-MB-435 | Activity | 72.2 | % | 10.1021/np050519e |
| Homo sapiens | MDA-MB-435 | IC50 | 3100.0 | nM | 10.1021/np050519e |
| Homo sapiens | NCI-H460 | Activity | 80.0 | % | 10.1021/np050519e |
| Homo sapiens | NCI-H460 | Activity | nan | None | 10.1021/np050519e |
| Homo sapiens | NCI-H460 | IC50 | 64600.0 | nM | 10.1021/np050519e |
| Rattus norvegicus | A10 | Activity | nan | None | 10.1021/np050519e |
| Rattus norvegicus | A10 | Inhibition | 85.0 | % | 10.1021/np050519e |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1021/np050519e |