Leu-Leu
AlkaPlorer ID: AK005623
Synonym: 'LL', 'L-Leu-L-Leu', 'leucylleucine', 'LL dipeptide', 'H-L-Leu-L-Leu-OH', 'H-Leu-Leu-OH'
IUPAC Name: (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoic acid
Structure
SMILES: CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)O
InChI: InChI=1S/C12H24N2O3/c1-7(2)5-9(13)11(15)14-10(12(16)17)6-8(3)4/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17)/t9-,10-/m0/s1
InChIKey: LCPYQJIKPJDLLB-UWVGGRQHSA-N
Source
Properties Information
Molecule Weight: 244.33499999999995
TPSA？: 92.42
MolLogP？: 0.9753000000000004
Number of H-Donors: 3
Number of H-Acceptors: 3
RingCount: 0
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Oligopeptide transporter small intestine isoform | EC50 | 80000.0 | nM | 10.1021/jm0511029 |
| Homo sapiens | Oligopeptide transporter small intestine isoform | IC50 | 170000.0 | nM | 10.1021/jm0511029 |
| Homo sapiens | Oligopeptide transporter small intestine isoform | Inhibition | 80.0 | % | None |
| Homo sapiens | Oligopeptide transporter small intestine isoform | max activation | 108.0 | % | 10.1021/jm0511029 |
| Homo sapiens | Oligopeptide transporter small intestine isoform | Ratio | 1400.0 | None | 10.1021/jm0511029 |
| Saccharomyces cerevisiae | General amino-acid permease GAP1 | Inhibition | 15.0 | % | 10.1038/nchembio.132 |
| None | No relevant target | LogP | 1.46 | None | 10.1021/jm00393a031 |
| None | Unchecked | Log 1/T | 2.26 | None | 10.1021/jm00393a031 |
| None | Unchecked | Log 1/T | 2.35 | None | 10.1021/jm00014a022 |