Heliparvifoline
AlkaPlorer ID: AK006395
Synonym: None
IUPAC Name: 4,8-dimethoxyfuro[2,3-b]quinolin-7-ol
Structure
SMILES: COC1=C2C=CC(O)=C(OC)C2=NC2=C1C=CO2
InChI: InChI=1S/C13H11NO4/c1-16-11-7-3-4-9(15)12(17-2)10(7)14-13-8(11)5-6-18-13/h3-6,15H,1-2H3
InChIKey: LJKPBWHZRNQEMO-UHFFFAOYSA-N
Reference
Alkaloids and Coumarins From Haplophyllum Thesioides
PubChem CID: 5281846
CAS: 5876-17-5
LOTUS: LTS0092283
SuperNatural Ⅲ: SN0207123
COCONUT: CNP0289815
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 245.23399999999995
TPSA？: 64.72
MolLogP？: 2.7038
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | IC50 | 10000.0 | nM | 10.1021/np800276f |
| Homo sapiens | FAD-linked sulfhydryl oxidase ALR | AC50 | 490.0 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 3548.1 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4D-like | Potency | 28183.8 | nM | None |
| Human immunodeficiency virus 1 | Human immunodeficiency virus 1 | EC50 | 5850.0 | nM | 10.1016/j.ejmech.2021.113220 |
| Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | IC50 | 200.0 | ug.mL-1 | 10.1021/np50073a012 |
| Plasmodium falciparum | Plasmodium falciparum | Inhibition | -12.0 | % | 10.6019/CHEMBL4888484 |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 2616.9 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Z score | 2.38 | None | 10.6019/CHEMBL4888484 |
| Simian virus 40 | Large T antigen | IC50 | 19960.0 | nM | None |
| None | Neutrophil | IC50 | 57320.0 | nM | 10.1021/np070186g |
| None | Unchecked | IC50 | 11490.0 | nM | None |