Navigation

name Structure Reference Source Properties Activities Metabolism

Huperzine B

AlkaPlorer ID: AK006529

Synonym: None

IUPAC Name: (1R,9R,10R)-16-methyl-6,14-diazatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,16-trien-5-one

Structure

SMILES: CC1=C[C@H]2CC3=C(C=CC(O)=N3)[C@]3(C1)NCCC[C@H]23

copy

InChI: InChI=1S/C16H20N2O/c1-10-7-11-8-14-13(4-5-15(19)18-14)16(9-10)12(11)3-2-6-17-16/h4-5,7,11-12,17H,2-3,6,8-9H2,1H3,(H,18,19)/t11-,12+,16+/m0/s1

copy

InChIKey: YYWGABLTRMRUIT-HWWQOWPSSA-N

copy

Source

Species Genus Family Order Class Phylum Kingdom Domain
Huperzia serrata Huperzia Lycopodiaceae Lycopodiales Lycopodiopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 256.34899999999993

TPSA？: 45.150000000000006

MolLogP？: 2.5044000000000004

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bos taurus Acetylcholinesterase Ki 794.0 nM 10.1016/s0960-894x(02)00204-4
Felis catus Felis catus ED50 0.08 umol.kg-1 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus HR -8.0 delta % 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus MAP -17.0 delta % 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus Max rev 156.0 % 10.1016/s0960-894x(02)00482-1
Felis catus Felis catus Vagus 102.0 delta % 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholinesterase EC50 19.0 nM 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetylcholinesterase IC50 30.0 nM 10.1016/s0960-894x(02)00482-1
Homo sapiens Acetyl-CoA acetyltransferase, mitochondrial Inhibition nan % 10.1016/j.bmcl.2016.04.019
Rattus norvegicus Acetylcholinesterase IC50 19300.0 nM 10.1016/j.bmc.2006.11.009
Rattus norvegicus Acetylcholinesterase IC50 19300.0 nM 10.1021/jm0496178
Rattus norvegicus Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) Selectivity index 11.8 None 10.1021/jm0496178
Rattus norvegicus Butyrylcholinesterase IC50 227000.0 nM 10.1021/jm0496178
Rattus norvegicus Butyrylcholinesterase IC50 228000.0 nM 10.1016/j.bmc.2006.11.009
Torpedo californica Acetylcholinesterase Ki 334.0 nM 10.1021/jm701253t
None Unchecked Ratio IC50 12.0 None 10.1016/j.bmc.2006.11.009

Metabolism Information