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Periglaucine B

AlkaPlorer ID: AK006744

Synonym: 'periglaucine B', '(+)-Periglaucine A', '(7alpha,8beta,10beta)-8,10-epoxy-7,8-dimethoxy-2,3-methylenebis(oxy)-17-methyl-6-oxohasubanan', '(+)-Periglaucine B', 'periglaucine A', 'Periglaucine A', '(7beta,8beta,10beta)-8,10-epoxy-7,8-dimethoxy-2,3-methylenebis(oxy)-17-methyl-6-oxohasubanan', 'Periglaucine B'

IUPAC Name: (1S,11R,13S,14S,15R)-14,15-dimethoxy-20-methyl-5,7,21-trioxa-20-azahexacyclo[11.4.3.111,14.01,13.02,10.04,8]henicosa-2,4(8),9-trien-16-one

Structure

SMILES: CO[C@@H]1C(=O)C[C@]23CCN(C)[C@@]24C[C@@H](O[C@]14OC)C1=CC2=C(C=C13)OCO2

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InChI: InChI=1S/C20H23NO6/c1-21-5-4-18-8-13(22)17(23-2)20(24-3)19(18,21)9-16(27-20)11-6-14-15(7-12(11)18)26-10-25-14/h6-7,16-17H,4-5,8-10H2,1-3H3/t16-,17-,18+,19+,20-/m1/s1

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InChIKey: QJDYNQYLCIPODD-SWBPCFCJSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Pericampylus glaucus Pericampylus Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 373.40500000000014

TPSA？: 66.46000000000001

MolLogP？: 1.5329

Number of H-Donors: 0

Number of H-Acceptors: 7

RingCount: 6

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Hepatitis B virus Hepatitis B virus IC50 1040000.0 nM 10.1021/np070479+
Hepatitis B virus Hepatitis B virus IC50 3410000.0 nM 10.1021/np070479+
Homo sapiens C8166 CC50 536000.0 nM 10.1021/np070479+
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 204000.0 nM 10.1021/np070479+
None ADMET CC50 2960000.0 nM 10.1021/np070479+
None Unchecked Ratio CC50/EC50 4.03 None 10.1021/np070479+
None Unchecked Ratio CC50/IC50 1.0 None 10.1021/np070479+
None Unchecked Ratio CC50/IC50 2.85 None 10.1021/np070479+

Metabolism Information