7-Bromoisatin
AlkaPlorer ID: AK007056
Synonym: None
IUPAC Name: 7-bromo-1H-indole-2,3-dione
Structure
SMILES: C1=CC2=C(C(=C1)Br)NC(=O)C2=O
InChI: InChI=1S/C8H4BrNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
InChIKey: OCVKSIWBTJCXPV-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 226.02899999999997
TPSA？: 46.17
MolLogP？: 1.5838999999999994
Number of H-Donors: 1
Number of H-Acceptors: 2
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Potency | 14125.4 | nM | None |
| Homo sapiens | ATPase family AAA domain-containing protein 5 | Potency | 20587.8 | nM | None |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 112201.8 | nM | None |
| Homo sapiens | DNA polymerase eta | Potency | 89125.1 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 31622.8 | nM | None |
| Homo sapiens | Geminin | Potency | 25929.0 | nM | None |
| Homo sapiens | Geminin | Potency | 29092.9 | nM | None |
| Homo sapiens | HepG2 | Potency | 35481.3 | nM | None |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 14125.4 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 29092.9 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 8199.5 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 11582.1 | nM | None |
| Homo sapiens | U-937 | IC50 | 83000.0 | nM | 10.1016/j.bmc.2006.10.035 |
| Homo sapiens | U-937 | IC50 | 83176.38 | nM | 10.1016/j.ejmech.2009.12.010 |
| Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 | Potency | 50118.7 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | AbsAC35 | 30.46 | uM | None |
| Plasmodium falciparum 3D7 | HSP40, subfamily A, putative | AbsAC1000_uM | 11.59 | uM | None |
| None | Unchecked | Potency | 12589.3 | nM | None |