2,5-Dideoxy-2,5-imino-glycero-D-manno-heptitol
AlkaPlorer ID: AK007066
Synonym: ''
IUPAC Name: (2R,3R,4R,5R)-2-[(1S)-1,2-dihydroxyethyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol
Structure
SMILES: OC[C@@H](O)[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
InChI: InChI=1S/C7H15NO5/c9-1-3-6(12)7(13)5(8-3)4(11)2-10/h3-13H,1-2H2/t3-,4-,5-,6-,7-/m1/s1
InChIKey: ZJRUOSSQTZGFJV-NYMZXIIRSA-N
Reference
α-Glucosidase-inhibitory iminosugars from the leaves of Suregada glomerulata
PubChem CID: 10198040
LOTUS: LTS0045700
SuperNatural Ⅲ: SN0472211-04
NPASS: NPC101746
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Suregada glomerulata | Suregada | Euphorbiaceae | Malpighiales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 193.19900000000004
TPSA？: 113.18
MolLogP？: -3.605899999999999
Number of H-Donors: 6
Number of H-Acceptors: 6
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Glycogen debranching enzyme | IC50 | 100000.0 | nM | 10.1016/j.bmc.2008.01.032 |
| Mus musculus | Mus musculus | Activity | 136.7 | mg/dl | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | Activity | 147.3 | mg/dl | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | Activity | 150.3 | mg/dl | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | Activity | 179.0 | mg/dl | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | Activity | 216.2 | mg/dl | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | Activity | 262.8 | mg/dl | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | AUC | 2936000.0 | ng.hr.mL-1 | 10.1016/j.bmc.2013.07.048 |
| Mus musculus | Mus musculus | AUC | 3905000.0 | ng.hr.mL-1 | 10.1016/j.bmc.2013.07.048 |
| None | Unchecked | IC50 | 920.0 | nM | 10.1016/j.bmc.2013.07.048 |
| None | Unchecked | IC50 | 150000.0 | nM | 10.1016/j.bmc.2008.01.032 |