Cribrostatin 6
AlkaPlorer ID: AK007148
Synonym: None
IUPAC Name: 9-ethoxy-3,8-dimethylimidazo[5,1-a]isoquinoline-7,10-dione
Structure
SMILES: CCOC1=C(C)C(=O)C2=C(C1=O)C1=CN=C(C)N1C=C2
InChI: InChI=1S/C15H14N2O3/c1-4-20-15-8(2)13(18)10-5-6-17-9(3)16-7-11(17)12(10)14(15)19/h5-7H,4H2,1-3H3
InChIKey: WTVDYUNSMHFLEA-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | None | Niphatidae | Haplosclerida | Demospongiae | Porifera | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 270.28799999999995
TPSA？: 60.67
MolLogP？: 2.3322200000000004
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | MIC | 2.0 | ug.mL-1 | 10.1021/np020012t |
| Candida albicans | Candida albicans | MIC | 64.0 | ug.mL-1 | 10.1021/np020012t |
| Cryptococcus neoformans | Cryptococcus neoformans | MIC | 2.0 | ug.mL-1 | 10.1021/np020012t |
| Enterobacter cloacae | Enterobacter cloacae | MIC | 64.0 | ug.mL-1 | 10.1021/np020012t |
| Enterococcus faecalis | Enterococcus faecalis | MIC | 32.0 | ug.mL-1 | 10.1021/np020012t |
| Escherichia coli | Escherichia coli | MIC | 64.0 | ug.mL-1 | 10.1021/np020012t |
| Homo sapiens | BXPC-3 | GI50 | 1.0 | ug.mL-1 | 10.1021/np020012t |
| Homo sapiens | DU-145 | GI50 | 0.38 | ug.mL-1 | 10.1021/np020012t |
| Homo sapiens | KM-20L2 | GI50 | 1.0 | ug.mL-1 | 10.1021/np020012t |
| Homo sapiens | MCF7 | GI50 | 0.21 | ug.mL-1 | 10.1021/np020012t |
| Homo sapiens | NCI-H460 | GI50 | 1.0 | ug.mL-1 | 10.1021/np020012t |
| Homo sapiens | SF-268 | GI50 | 0.24 | ug.mL-1 | 10.1021/np020012t |
| Micrococcus luteus | Micrococcus luteus | MIC | 16.0 | ug.mL-1 | 10.1021/np020012t |
| Mus musculus | P388 | ED50 | 0.3 | ug ml-1 | 10.1021/np020012t |
| Mus musculus | P388 | GI50 | 0.29 | ug.mL-1 | 10.1021/np020012t |
| Neisseria gonorrhoeae | Neisseria gonorrhoeae | MIC | 0.0625 | ug.mL-1 | 10.1021/np020012t |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 16.0 | ug.mL-1 | 10.1021/np020012t |
| Stenotrophomonas maltophilia | Stenotrophomonas maltophilia | MIC | 64.0 | ug.mL-1 | 10.1021/np020012t |
| Streptococcus | Streptococcus | MIC | 16.0 | ug.mL-1 | 10.1021/np020012t |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC | 0.5 | ug.mL-1 | 10.1021/np020012t |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC | 1.0 | ug.mL-1 | 10.1021/np020012t |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC | 2.0 | ug.mL-1 | 10.1021/np020012t |