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Lysicamine

AlkaPlorer ID: AK007330

Synonym: None

IUPAC Name: 15,16-dimethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one

Structure

SMILES: COC1=CC2=CC=NC3=C2C(=C1OC)C1=CC=CC=C1C3=O

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InChI: InChI=1S/C18H13NO3/c1-21-13-9-10-7-8-19-16-14(10)15(18(13)22-2)11-5-3-4-6-12(11)17(16)20/h3-9H,1-2H3

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InChIKey: DPBMWJXWUINLQT-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 291.30600000000004

TPSA？: 48.42

MolLogP？: 3.463400000000002

Number of H-Donors: 0

Number of H-Acceptors: 4

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Candida albicans Candida albicans MIC nan None 10.1021/np100013r
Candida dubliniensis Candida dubliniensis MIC 100.0 ug.mL-1 10.1021/np100013r
Candida parapsilosis Candida parapsilosis MIC nan None 10.1021/np100013r
Candida tropicalis Candida tropicalis MIC nan None 10.1021/np100013r
Chlorocebus sabaeus Vero CC50 500000.0 nM 10.1021/np970382v
Chlorocebus sabaeus Vero MTC 250.0 uM 10.1021/np970382v
Electrophorus electricus Acetylcholinesterase IC50 16100.0 nM 10.1021/np100247r
Escherichia coli Escherichia coli MIC nan None 10.1021/np100013r
Homo sapiens HepG2 IC50 6.2 ug.mL-1 10.1021/np0005208
Homo sapiens HepG2 IC50 40000.0 nM 10.1016/j.ejmech.2022.114141
Homo sapiens KB ED50 10.0 ug ml-1 10.1021/np50019a011
Homo sapiens MGC-803 IC50 15800.0 nM 10.1016/j.ejmech.2022.114141
Homo sapiens SK-OV-3 IC50 12100.0 nM 10.1016/j.ejmech.2022.114141
Homo sapiens T-24 IC50 7300.0 nM 10.1016/j.ejmech.2022.114141
Homo sapiens WI-38 IC50 6700.0 nM 10.1016/j.ejmech.2022.114141
Kocuria rhizophila Kocuria rhizophila MIC nan None 10.1021/np100013r
Mus musculus RAW264.7 Activity nan None 10.1021/acs.jnatprod.1c00146
Mus musculus RAW264.7 IC50 6400.0 nM 10.1021/acs.jnatprod.1c00146
Nakaseomyces glabratus Nakaseomyces glabratus MIC nan None 10.1021/np100013r
Poliovirus 2 Poliovirus 2 Activity nan None 10.1021/np970382v
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1021/np100013r
Rattus norvegicus Dopamine transporter IC50 100000.0 nM 10.1021/np50124a001
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 300.0 ug ml-1 10.1021/np50103a009
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 390.0 ug ml-1 10.1021/np50103a009
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 500.0 ug ml-1 10.1021/np50103a009
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity 8000.0 ug ml-1 10.1021/np50103a009
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/np100013r
Staphylococcus epidermidis Staphylococcus epidermidis MIC 50.0 ug.mL-1 10.1021/np100013r
None ADMET Inhibition 22.5 % 10.1016/j.bmc.2012.11.038
None ADMET Inhibition 69.0 % 10.1016/j.bmc.2012.11.038
None NON-PROTEIN TARGET Activity 0.86 None 10.1021/np100013r
None NON-PROTEIN TARGET IC50 2.4 ug.mL-1 10.1021/np0005208
None Platelet Activity 16.3 % 10.1021/np9800046
None Platelet Activity 55.2 % 10.1021/np9800046
None Platelet Activity 83.7 % 10.1021/np9800046
None Platelet Activity 88.9 % 10.1021/np9800046
None Unchecked IC50 17800.0 nM 10.1021/acs.jnatprod.1c00146
None Unchecked Inhibition -1.5 % 10.1016/j.bmc.2012.11.038
None Unchecked Inhibition 4.8 % 10.1016/j.bmc.2012.11.038
None Unchecked Inhibition 8.7 % 10.1016/j.bmc.2012.11.038
None Unchecked Inhibition 65.3 % 10.1016/j.bmc.2012.11.038

Metabolism Information