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mifepristone

AlkaPlorer ID: AK007418

Synonym: None

IUPAC Name: (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Structure

SMILES: CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](C3=CC=C(N(C)C)C=C3)C[C@@]21C

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InChI: InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

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InChIKey: VKHAHZOOUSRJNA-GCNJZUOMSA-N

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Reference

PubChem CID: 55245

CAS: 122742-25-0

SuperNatural Ⅲ: SN0392574-02

NPASS: NPC375265

Source

Species Genus Family Order Class Phylum Kingdom Domain
Trifolium pratense Trifolium Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 429.6040000000001

TPSA？: 40.54

MolLogP？: 5.406500000000006

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 17.82 % 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Bos taurus Progesterone receptor IC50 3.245 nM None
Bos taurus Progesterone receptor Ki 0.423 nM None
Candida albicans Candida albicans Inhibition 3.98 % 10.6019/CHEMBL4513141
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Canis lupus familiaris Glucocorticoid receptor IC50 20.2 nM 10.1021/acs.jmedchem.8b00743
Canis lupus familiaris Glucocorticoid receptor IC50 32.6 nM 10.1021/acs.jmedchem.8b00743
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlamydia pneumoniae Chlamydia pneumoniae Activity nan None 10.1128/aac.01416-07
Chlamydia pneumoniae Chlamydia pneumoniae Inhibition nan % 10.1128/aac.01416-07
Cryptococcus neoformans Cryptococcus neoformans Inhibition -10.45 % 10.6019/CHEMBL4513141
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Equus caballus Ferritin light chain Potency 1995.3 nM None
Equus caballus Ferritin light chain Potency 10000.0 nM None
Equus caballus Ferritin light chain Potency 14125.4 nM None
Escherichia coli Escherichia coli Inhibition -7.81 % 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 20000.0 nM 10.6019/CHEMBL4513161
Escherichia coli K-12 Endonuclease 4 Potency 12589.3 nM None
Herpes simplex virus (type 1 / strain 17) Alpha trans-inducing protein (VP16) EC50 0.7 nM 10.1021/jm050205o
Homo sapiens A549 IC50 nan None 10.1016/j.bmc.2021.116003
Homo sapiens Acetylcholinesterase AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 2649.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 10281.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 26460.0 nM None
Homo sapiens Alpha-2b adrenergic receptor Ki 12082.0 nM None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 37.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor Activity 50.0 % 10.1016/j.bmcl.2007.07.055
Homo sapiens Androgen Receptor Activity nan None 10.1021/acs.jmedchem.8b00743
Homo sapiens Androgen Receptor Activity nan None 10.1021/jm701080t
Homo sapiens Androgen Receptor EC50 10.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Androgen Receptor EC50 11.9 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Androgen Receptor EC50 11.9 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Androgen Receptor Efficacy 6.0 % 10.1021/jm001000c
Homo sapiens Androgen Receptor Efficacy 7.0 % 10.1021/jm9801915
Homo sapiens Androgen Receptor Efficacy 75.0 % 10.1021/jm950747d
Homo sapiens Androgen Receptor Efficacy 75.0 % 10.1021/jm970699s
Homo sapiens Androgen Receptor Efficacy 79.0 % 10.1016/s0960-894x(03)00256-7
Homo sapiens Androgen Receptor Emax 100.0 % 10.1021/acs.jmedchem.8b00743
Homo sapiens Androgen Receptor Emax 100.0 % 10.1021/acs.jmedchem.9b00711
Homo sapiens Androgen Receptor IC50 1.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Androgen Receptor IC50 2.2 nM 10.1021/jm0342515
Homo sapiens Androgen Receptor IC50 5.0 nM 10.1021/acsmedchemlett.8b00058
Homo sapiens Androgen Receptor IC50 5.0 nM 10.1021/jm025555e
Homo sapiens Androgen Receptor IC50 5.0 nM 10.1021/jm950747d
Homo sapiens Androgen Receptor IC50 5.0 nM 10.1021/jm970699s
Homo sapiens Androgen Receptor IC50 6.9 nM 10.1016/j.bmc.2008.05.018
Homo sapiens Androgen Receptor IC50 6.9 nM 10.1016/j.bmcl.2008.08.015
Homo sapiens Androgen Receptor IC50 6.9 nM 10.1016/j.bmcl.2010.06.109
Homo sapiens Androgen Receptor IC50 6.9 nM 10.1021/jm701080t
Homo sapiens Androgen Receptor IC50 7.8 nM 10.1021/jm0342515
Homo sapiens Androgen Receptor IC50 8.3 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Androgen Receptor IC50 8.8 nM 10.1021/jm050205o
Homo sapiens Androgen Receptor IC50 10.0 nM 10.1021/jm001000c
Homo sapiens Androgen Receptor IC50 23.0 nM 10.1021/jm0342515
Homo sapiens Androgen Receptor IC50 63.1 nM 10.1021/jm100447c
Homo sapiens Androgen Receptor IC50 89.0 nM 10.1016/j.bmcl.2004.02.048
Homo sapiens Androgen Receptor Inhibition 95.0 % 10.1016/j.bmc.2008.05.018
Homo sapiens Androgen Receptor Ki 0.65 nM 10.1021/jm0400045
Homo sapiens Androgen Receptor Ki 4.6 nM 10.1021/jm0105530
Homo sapiens Androgen Receptor Ki 5.95 nM 10.1021/acs.jmedchem.5b00736
Homo sapiens Androgen Receptor Ki 8.4 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Androgen Receptor Ki 10.6 nM 10.1021/jm950747d
Homo sapiens Androgen Receptor Ki 22.0 nM 10.1021/jm970699s
Homo sapiens Androgen Receptor Potency 5.0 nM 10.1021/jm9801915
Homo sapiens Androgen Receptor Potency 15848.9 nM None
Homo sapiens Androgen Receptor Potency 25118.9 nM None
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Ataxin-2 Potency 25118.9 nM None
Homo sapiens Ataxin-2 Potency 28183.8 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 18348.9 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 29081.0 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 17400.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens BGC-823 IC50 nan None 10.1016/j.bmc.2021.116003
Homo sapiens Bile acid receptor FXR Potency 39810.7 nM None
Homo sapiens Bile salt export pump IC50 2020.0 nM 10.1093/toxsci/kft176
Homo sapiens Bloom syndrome protein Potency 39810.7 nM None
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 12589.3 nM None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 134.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 14125.4 nM None
Homo sapiens Chromobox protein homolog 1 Potency 25118.9 nM None
Homo sapiens Cyclooxygenase-1 AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C8 IC50 1500.0 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Cytochrome P450 2C8 IC50 1500.0 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Cytochrome P450 2C9 IC50 4900.0 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 9500.0 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Cytochrome P450 3A4 IC50 9500.0 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 K 0.062 /min 10.1021/acs.jmedchem.8b01326
Homo sapiens Cytochrome P450 3A4 K 0.066 /min 10.1021/acs.jmedchem.8b01326
Homo sapiens Cytochrome P450 3A4 Ki 4700.0 nM 10.1021/acs.jmedchem.9b01617
Homo sapiens Cytochrome P450 3A4 Ki 4700.0 nM 10.2174/138920005774330639
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Kinact 0.089 /min 10.1021/acs.jmedchem.9b01617
Homo sapiens Cytochrome P450 3A4 Kinact 0.089 min-1 10.2174/138920005774330639
Homo sapiens Cytochrome P450 3A4 Log 1/Km -1.021 None 10.1016/j.bmcl.2005.06.015
Homo sapiens Cytochrome P450 3A4 Ratio 0.02 /uM/min 10.1124/dmd.110.034074
Homo sapiens Cytochrome P450 3A4 Ratio 64.0 None 10.1021/acs.jmedchem.8b01857
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 251188.6 nM None
Homo sapiens DNA polymerase iota Potency 125.9 nM None
Homo sapiens DNA polymerase iota Potency 31622.8 nM None
Homo sapiens Dopamine D1 receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D1 receptor Potency 10.3 nM None
Homo sapiens Dopamine D1 receptor Potency 2310.8 nM None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor Efficacy 40.0 % 10.1021/jm950747d
Homo sapiens Estrogen receptor Efficacy 40.0 % 10.1021/jm9801915
Homo sapiens Estrogen receptor Efficacy 59.0 % 10.1016/s0960-894x(03)00256-7
Homo sapiens Estrogen receptor IC50 1000.0 nM 10.1021/jm025555e
Homo sapiens Estrogen receptor IC50 2244.0 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Estrogen receptor IC50 10000.0 nM 10.1021/jm950747d
Homo sapiens Estrogen receptor Ki 10000.0 nM 10.1021/jm950747d
Homo sapiens Estrogen receptor Potency 1000.0 nM 10.1021/jm9801915
Homo sapiens Estrogen receptor alpha AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha Activity nan None 10.1021/acs.jmedchem.5b00736
Homo sapiens Estrogen receptor alpha EC50 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor alpha EC50 nan None 10.1021/jm701080t
Homo sapiens Estrogen receptor alpha Efficacy 20.0 % 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor alpha IC50 1000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor alpha IC50 5000.0 nM 10.1016/j.bmc.2008.05.018
Homo sapiens Estrogen receptor alpha IC50 5000.0 nM 10.1016/j.bmcl.2008.08.015
Homo sapiens Estrogen receptor alpha IC50 5000.0 nM 10.1016/j.bmcl.2010.06.109
Homo sapiens Estrogen receptor alpha IC50 23638.0 nM None
Homo sapiens Estrogen receptor alpha IC50 nan nM 10.1016/j.bmcl.2004.02.048
Homo sapiens Estrogen receptor alpha IC50 nan None 10.1021/jm701080t
Homo sapiens Estrogen receptor alpha Inhibition 44.0 % 10.1021/jm0105530
Homo sapiens Estrogen receptor alpha Inhibition 50.0 % 10.1016/j.bmc.2008.05.018
Homo sapiens Estrogen receptor alpha Ki 200.0 nM 10.1021/jm0400045
Homo sapiens Estrogen receptor alpha Ki 6754.0 nM None
Homo sapiens Estrogen receptor alpha Ki 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor alpha Potency 15848.9 nM None
Homo sapiens Estrogen receptor alpha Potency 22387.2 nM None
Homo sapiens Estrogen receptor beta EC50 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor beta Efficacy 20.0 % 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor beta IC50 812.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Inhibition 92.0 % 10.1021/jm0105530
Homo sapiens Estrogen receptor beta Ki 750.0 nM 10.1021/jm0400045
Homo sapiens Estrogen receptor beta Ki 2876.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Estrogen-related receptor alpha Activity 50.0 % 10.1016/j.bmcl.2007.07.055
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 7307.8 nM None
Homo sapiens Geminin Potency 12589.3 nM None
Homo sapiens Geminin Potency 29092.9 nM None
Homo sapiens Geminin Potency 29855.4 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon-like peptide 1 receptor Potency 11220.2 nM None
Homo sapiens Glucocorticoid receptor AC50 1.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 26.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor Activity 4.0 % 10.1016/j.bmcl.2007.06.066
Homo sapiens Glucocorticoid receptor Activity 30.0 % 10.1016/j.bmcl.2014.05.039
Homo sapiens Glucocorticoid receptor Activity 99.7 % 10.1021/jm070778w
Homo sapiens Glucocorticoid receptor Activity 101.0 % 10.1021/jm100447c
Homo sapiens Glucocorticoid receptor Activity nan None 10.1021/acs.jmedchem.7b01690
Homo sapiens Glucocorticoid receptor Activity nan None 10.1021/acsmedchemlett.7b00527
Homo sapiens Glucocorticoid receptor Activity nan None 10.1021/jm701080t
Homo sapiens Glucocorticoid receptor Activity nan None 10.1021/jm801512v
Homo sapiens Glucocorticoid receptor Activity nan None 10.1021/jm901452y
Homo sapiens Glucocorticoid receptor Affinity 193.0 % 10.1016/S0960-894X(97)00397-1
Homo sapiens Glucocorticoid receptor Agonistic activity 59.0 % 10.1021/jm050205o
Homo sapiens Glucocorticoid receptor EC50 0.6 nM 10.1021/jm070370z
Homo sapiens Glucocorticoid receptor EC50 2.0 nM 10.1016/j.bmcl.2005.07.025
Homo sapiens Glucocorticoid receptor EC50 872.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Glucocorticoid receptor EC50 1000.0 nM 10.1016/j.bmcl.2007.06.066
Homo sapiens Glucocorticoid receptor EC50 2500.0 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Glucocorticoid receptor Efficacy 5.0 % 10.1073/pnas.0705517104
Homo sapiens Glucocorticoid receptor Efficacy 44.0 % 10.1016/j.bmcl.2005.07.025
Homo sapiens Glucocorticoid receptor Efficacy 95.0 % 10.1016/s0960-894x(03)00256-7
Homo sapiens Glucocorticoid receptor Efficacy 97.0 % 10.1021/acs.jmedchem.7b01690
Homo sapiens Glucocorticoid receptor Efficacy 97.0 % 10.1021/jm070370z
Homo sapiens Glucocorticoid receptor Efficacy 98.0 % 10.1021/jm950747d
Homo sapiens Glucocorticoid receptor Efficacy 98.0 % 10.1021/jm9801915
Homo sapiens Glucocorticoid receptor Emax 3.1 % 10.1021/acs.jmedchem.8b00743
Homo sapiens Glucocorticoid receptor IC50 0.008 nM 10.1021/jm0342515
Homo sapiens Glucocorticoid receptor IC50 0.298 nM 10.1021/acs.jmedchem.5b00736
Homo sapiens Glucocorticoid receptor IC50 0.6 nM 10.1016/j.bmc.2008.05.018
Homo sapiens Glucocorticoid receptor IC50 0.6 nM 10.1016/j.bmcl.2008.08.015
Homo sapiens Glucocorticoid receptor IC50 0.6 nM 10.1016/j.bmcl.2010.06.109
Homo sapiens Glucocorticoid receptor IC50 0.6 nM 10.1021/jm701080t
Homo sapiens Glucocorticoid receptor IC50 0.64 nM 10.1021/acs.jmedchem.1c01287
Homo sapiens Glucocorticoid receptor IC50 0.8 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Glucocorticoid receptor IC50 0.8 nM 10.1021/acsmedchemlett.8b00058
Homo sapiens Glucocorticoid receptor IC50 0.8 nM 10.1021/jm025555e
Homo sapiens Glucocorticoid receptor IC50 0.8 nM 10.1021/jm950747d
Homo sapiens Glucocorticoid receptor IC50 0.95 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Glucocorticoid receptor IC50 1.0 nM 10.1016/j.bmcl.2004.02.048
Homo sapiens Glucocorticoid receptor IC50 1.1 nM 10.1016/j.bmcl.2004.06.021
Homo sapiens Glucocorticoid receptor IC50 1.1 nM 10.1016/j.bmcl.2006.08.133
Homo sapiens Glucocorticoid receptor IC50 1.1 nM 10.1016/s0960-894x(03)00431-1
Homo sapiens Glucocorticoid receptor IC50 1.1 nM 10.1021/jm050205o
Homo sapiens Glucocorticoid receptor IC50 1.6 nM 10.1016/j.bmcl.2006.11.062
Homo sapiens Glucocorticoid receptor IC50 1.6 nM 10.1016/j.bmcl.2007.02.013
Homo sapiens Glucocorticoid receptor IC50 1.6 nM 10.1016/j.bmcl.2009.01.095
Homo sapiens Glucocorticoid receptor IC50 2.232 nM None
Homo sapiens Glucocorticoid receptor IC50 2.3 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Glucocorticoid receptor IC50 3.2 nM 10.1021/np9004882
Homo sapiens Glucocorticoid receptor IC50 3.26 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Glucocorticoid receptor IC50 3.3 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Glucocorticoid receptor IC50 3.5 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Glucocorticoid receptor IC50 4.677 nM 10.1021/jm060302x
Homo sapiens Glucocorticoid receptor IC50 4.677 nM 10.1021/jm070778w
Homo sapiens Glucocorticoid receptor IC50 4.8 nM 10.1016/j.bmcl.2004.06.021
Homo sapiens Glucocorticoid receptor IC50 4.8 nM 10.1016/j.bmcl.2004.06.022
Homo sapiens Glucocorticoid receptor IC50 4.8 nM 10.1021/jm050205o
Homo sapiens Glucocorticoid receptor IC50 5.0 nM 10.1016/j.bmcl.2004.02.048
Homo sapiens Glucocorticoid receptor IC50 5.0 nM 10.1016/j.bmcl.2006.08.133
Homo sapiens Glucocorticoid receptor IC50 5.0 nM 10.1016/s0960-894x(03)00431-1
Homo sapiens Glucocorticoid receptor IC50 5.754 nM 10.1021/jm060302x
Homo sapiens Glucocorticoid receptor IC50 5.754 nM 10.1021/jm070778w
Homo sapiens Glucocorticoid receptor IC50 6.0 nM 10.1016/j.bmcl.2007.08.064
Homo sapiens Glucocorticoid receptor IC50 6.31 nM 10.1021/jm100447c
Homo sapiens Glucocorticoid receptor IC50 6.918 nM 10.1016/j.bmcl.2007.06.066
Homo sapiens Glucocorticoid receptor IC50 8.7 nM 10.1021/acs.jmedchem.7b01690
Homo sapiens Glucocorticoid receptor IC50 11.48 nM 10.1016/j.bmcl.2007.06.066
Homo sapiens Glucocorticoid receptor IC50 13.0 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Glucocorticoid receptor IC50 14.8 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Glucocorticoid receptor IC50 15.0 nM 10.1021/acs.jmedchem.7b01690
Homo sapiens Glucocorticoid receptor IC50 17.8 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Glucocorticoid receptor IC50 1000.0 nM 10.1016/j.bmcl.2007.06.066
Homo sapiens Glucocorticoid receptor IC50 1000.0 nM 10.1021/jm060302x
Homo sapiens Glucocorticoid receptor IC50 1000.0 nM 10.1021/jm070778w
Homo sapiens Glucocorticoid receptor IC50 10000.0 nM 10.1021/jm100447c
Homo sapiens Glucocorticoid receptor Inhibition 97.0 % 10.1016/j.bmc.2008.05.018
Homo sapiens Glucocorticoid receptor Inhibition 100.0 % 10.1016/j.bmcl.2005.07.025
Homo sapiens Glucocorticoid receptor Inhibition 100.0 % 10.1016/j.bmcl.2007.06.066
Homo sapiens Glucocorticoid receptor Inhibition 100.0 % 10.1021/jm0105530
Homo sapiens Glucocorticoid receptor Inhibition nan % 10.1016/j.ejmech.2019.01.036
Homo sapiens Glucocorticoid receptor Inhibition nan % 10.1021/acs.jmedchem.9b00711
Homo sapiens Glucocorticoid receptor Inhibition nan % 10.1021/acsmedchemlett.7b00527
Homo sapiens Glucocorticoid receptor Kapp 32.0 uM 10.1016/j.ejmech.2019.01.036
Homo sapiens Glucocorticoid receptor Kd 15.0 nM 10.1016/j.bmc.2019.03.022
Homo sapiens Glucocorticoid receptor Ki 0.09 nM 10.1021/acs.jmedchem.7b00162
Homo sapiens Glucocorticoid receptor Ki 0.1 nM 10.1021/jm0400045
Homo sapiens Glucocorticoid receptor Ki 0.24 nM 10.1021/jm0105530
Homo sapiens Glucocorticoid receptor Ki 0.24 nM 10.1021/jm901452y
Homo sapiens Glucocorticoid receptor Ki 0.299 nM 10.1021/acs.jmedchem.5b00736
Homo sapiens Glucocorticoid receptor Ki 0.4 nM 10.1016/j.bmcl.2007.07.055
Homo sapiens Glucocorticoid receptor Ki 0.4 nM 10.1016/j.bmcl.2008.01.027
Homo sapiens Glucocorticoid receptor Ki 0.44 nM 10.1021/jm0400045
Homo sapiens Glucocorticoid receptor Ki 0.68 nM 10.1021/jm950747d
Homo sapiens Glucocorticoid receptor Ki 0.82 nM 10.1016/j.bmcl.2007.07.055
Homo sapiens Glucocorticoid receptor Ki 0.84 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Glucocorticoid receptor Ki 1.0 nM 10.1016/j.bmcl.2006.10.003
Homo sapiens Glucocorticoid receptor Ki 1.014 nM None
Homo sapiens Glucocorticoid receptor Ki 1.1 nM 10.1016/j.bmcl.2006.10.001
Homo sapiens Glucocorticoid receptor Ki 1.2 nM 10.1016/j.bmcl.2007.07.055
Homo sapiens Glucocorticoid receptor Ki 1.2 nM 10.1016/j.bmcl.2008.01.027
Homo sapiens Glucocorticoid receptor Ki 3.0 nM 10.1021/acs.jmedchem.7b00162
Homo sapiens Glucocorticoid receptor Ki 5.0 nM 10.1016/j.bmcl.2006.10.001
Homo sapiens Glucocorticoid receptor Ki 6.0 nM 10.1021/jm501758q
Homo sapiens Glucocorticoid receptor Ki 120.0 nM 10.1021/jm0400045
Homo sapiens Glucocorticoid receptor Ki 169.0 nM 10.1016/j.bmcl.2006.10.001
Homo sapiens Glucocorticoid receptor Kif 2.0 nM 10.1021/jm0105530
Homo sapiens Glucocorticoid receptor %max 4.0 % 10.1021/jm060302x
Homo sapiens Glucocorticoid receptor pEC50 nan None 10.1021/jm060302x
Homo sapiens Glucocorticoid receptor pEC50 nan None 10.1021/jm070778w
Homo sapiens Glucocorticoid receptor Potency 0.8 nM 10.1021/jm9801915
Homo sapiens Glucocorticoid receptor Potency 25.1 nM None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 35481.3 nM None
Homo sapiens HCC1937 Activity nan None 10.1016/j.ejmech.2018.01.056
Homo sapiens HCC1937 IC50 20000.0 nM 10.1016/j.ejmech.2018.01.056
Homo sapiens HCC1937 Inhibition nan % 10.1016/j.ejmech.2018.01.056
Homo sapiens HEK293 CC50 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEK293 Potency 8196.1 nM None
Homo sapiens HERG AC50 25000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone acetyltransferase GCN5 Potency 39810.7 nM None
Homo sapiens Histone deacetylase 6 Inhibition -4.94 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -2.53 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 1995.3 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 2818.4 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 9466.2 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 12589.3 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens AUC 77955.22 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens Cmax 5819.37 nM 10.1128/aac.01416-07
Homo sapiens Homo sapiens Css 7.561 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Huntingtin Potency 35481.3 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 Survival 95.6 % 10.1021/jm501676v
Homo sapiens Kappa opioid receptor AC50 6453.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 20096.0 nM None
Homo sapiens Kappa opioid receptor Ki 8038.0 nM None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Lysine-specific demethylase 4A Potency 15848.9 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Potency 39810.7 nM None
Homo sapiens MAP kinase p38 alpha IC50 83061.0 nM None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF-10A IC50 nan None 10.1016/j.bmc.2021.116003
Homo sapiens MCF7 IC50 24030.0 nM 10.1016/j.bmc.2021.116003
Homo sapiens MDA-MB-231 IC50 nan None 10.1016/j.bmc.2021.116003
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Mineralocorticoid receptor Activity 50.0 % 10.1016/j.bmcl.2007.07.055
Homo sapiens Mineralocorticoid receptor EC50 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Mineralocorticoid receptor EC50 nan None 10.1021/jm701080t
Homo sapiens Mineralocorticoid receptor Efficacy 20.0 % 10.1016/j.bmc.2010.04.092
Homo sapiens Mineralocorticoid receptor Efficacy 76.0 % 10.1016/s0960-894x(03)00256-7
Homo sapiens Mineralocorticoid receptor Efficacy 77.0 % 10.1021/jm950747d
Homo sapiens Mineralocorticoid receptor Efficacy 77.0 % 10.1021/jm9801915
Homo sapiens Mineralocorticoid receptor IC50 590.0 nM 10.1016/j.bmc.2008.05.018
Homo sapiens Mineralocorticoid receptor IC50 590.0 nM 10.1016/j.bmcl.2008.08.015
Homo sapiens Mineralocorticoid receptor IC50 590.0 nM 10.1016/j.bmcl.2010.06.109
Homo sapiens Mineralocorticoid receptor IC50 1000.0 nM 10.1021/jm025555e
Homo sapiens Mineralocorticoid receptor IC50 1000.0 nM 10.1021/jm950747d
Homo sapiens Mineralocorticoid receptor IC50 1155.0 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Mineralocorticoid receptor IC50 6000.0 nM 10.1016/j.bmcl.2004.02.048
Homo sapiens Mineralocorticoid receptor IC50 6000.0 nM 10.1021/jm050205o
Homo sapiens Mineralocorticoid receptor IC50 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Mineralocorticoid receptor IC50 nan None 10.1021/jm701080t
Homo sapiens Mineralocorticoid receptor Inhibition 69.7 % 10.1021/jm0105530
Homo sapiens Mineralocorticoid receptor Inhibition 96.0 % 10.1016/j.bmc.2008.05.018
Homo sapiens Mineralocorticoid receptor Ki 640.0 nM 10.1021/jm0400045
Homo sapiens Mineralocorticoid receptor Ki 851.0 nM 10.1021/acs.jmedchem.5b00736
Homo sapiens Mineralocorticoid receptor Ki 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Mineralocorticoid receptor Kif 10.0 nM 10.1021/jm0105530
Homo sapiens Mineralocorticoid receptor Potency 1000.0 nM 10.1021/jm9801915
Homo sapiens Monoamine oxidase A AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens M-phase phosphoprotein 8 Potency 11917.3 nM None
Homo sapiens M-phase phosphoprotein 8 Potency 15848.9 nM None
Homo sapiens Multidrug resistance-associated protein 1 Activity nan None 10.1006/bbrc.1999.0671
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 8000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 2457.0 nM None
Homo sapiens Mu opioid receptor Ki 997.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide S receptor Potency 12589.3 nM None
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 21689.9 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 23109.3 nM None
Homo sapiens PC-3 IC50 nan None 10.1016/j.bmc.2021.116003
Homo sapiens Peripheral myelin protein 22 Potency 30131.3 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 14125.4 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 25118.9 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 14125.4 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 25118.9 nM None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/0014-5793(94)01186-9
Homo sapiens P-glycoprotein 1 Activity nan None 10.1074/jbc.m010173200
Homo sapiens Phosphodiesterase 3A AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 3A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 16000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Pregnane X receptor AC50 29499.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 5623.4 nM None
Homo sapiens Prelamin-A/C Potency 17782.8 nM None
Homo sapiens Prelamin-A/C Potency 19952.6 nM None
Homo sapiens Progesterone receptor AC50 1.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 21.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 34.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor Activity 1.3 nM 10.1016/j.bmcl.2008.01.027
Homo sapiens Progesterone receptor Activity 6.0 % 10.1016/j.bmcl.2014.05.039
Homo sapiens Progesterone receptor Activity 50.0 % 10.1016/j.bmcl.2007.07.055
Homo sapiens Progesterone receptor Activity nan None 10.1021/acsmedchemlett.8b00058
Homo sapiens Progesterone receptor Affinity 36.0 % 10.1016/S0960-894X(97)00397-1
Homo sapiens Progesterone receptor EC50 0.3 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor EC50 10000.0 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Progesterone receptor EC50 nan nM 10.1016/s0960-894x(03)00255-5
Homo sapiens Progesterone receptor EC50 nan nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor Efficacy 20.0 % 10.1016/j.bmc.2010.04.092
Homo sapiens Progesterone receptor Efficacy 20.0 % 10.1021/jm950747d
Homo sapiens Progesterone receptor Efficacy 92.0 % 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor Efficacy 93.0 % 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor Efficacy 96.0 % 10.1021/jm970699s
Homo sapiens Progesterone receptor Efficacy 99.0 % 10.1016/s0960-894x(03)00255-5
Homo sapiens Progesterone receptor Efficacy 99.0 % 10.1016/s0960-894x(98)00482-x
Homo sapiens Progesterone receptor Efficacy 99.0 % 10.1021/jm9801915
Homo sapiens Progesterone receptor Efficacy nan None 10.1016/s0960-894x(03)00255-5
Homo sapiens Progesterone receptor Efficacy nan None 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor IC50 0.021 nM 10.1021/jm800985z
Homo sapiens Progesterone receptor IC50 0.025 nM 10.1021/jm001000c
Homo sapiens Progesterone receptor IC50 0.028 nM 10.1021/jm001000c
Homo sapiens Progesterone receptor IC50 0.045 nM 10.1021/jm800985z
Homo sapiens Progesterone receptor IC50 0.05 nM 10.1016/j.bmc.2010.01.048
Homo sapiens Progesterone receptor IC50 0.054 nM 10.1016/j.bmcl.2007.08.064
Homo sapiens Progesterone receptor IC50 0.073 nM 10.1021/acsmedchemlett.8b00058
Homo sapiens Progesterone receptor IC50 0.1 nM 10.1016/s0960-894x(02)00746-1
Homo sapiens Progesterone receptor IC50 0.13 nM 10.1021/jm025555e
Homo sapiens Progesterone receptor IC50 0.18 nM 10.1021/jm950747d
Homo sapiens Progesterone receptor IC50 0.18 nM 10.1021/jm970699s
Homo sapiens Progesterone receptor IC50 0.2 nM 10.1016/j.bmc.2008.05.018
Homo sapiens Progesterone receptor IC50 0.2 nM 10.1016/j.bmcl.2008.08.015
Homo sapiens Progesterone receptor IC50 0.2 nM 10.1016/j.bmcl.2010.06.109
Homo sapiens Progesterone receptor IC50 0.2 nM 10.1016/s0960-894x(01)00554-6
Homo sapiens Progesterone receptor IC50 0.2 nM 10.1016/s0960-894x(02)00025-2
Homo sapiens Progesterone receptor IC50 0.2 nM 10.1021/jm701080t
Homo sapiens Progesterone receptor IC50 0.2512 nM 10.1016/j.bmcl.2006.04.055
Homo sapiens Progesterone receptor IC50 0.3 nM 10.1016/s0960-894x(01)00554-6
Homo sapiens Progesterone receptor IC50 0.3 nM 10.1016/s0960-894x(03)00255-5
Homo sapiens Progesterone receptor IC50 0.3 nM 10.1016/s0960-894x(98)00482-x
Homo sapiens Progesterone receptor IC50 0.3 nM 10.1021/acsmedchemlett.8b00058
Homo sapiens Progesterone receptor IC50 0.3 nM 10.1021/jm025555e
Homo sapiens Progesterone receptor IC50 0.3 nM 10.1021/jm9801915
Homo sapiens Progesterone receptor IC50 0.35 nM 10.1021/jm950747d
Homo sapiens Progesterone receptor IC50 0.4 nM 10.1021/acs.jmedchem.8b00743
Homo sapiens Progesterone receptor IC50 0.4 nM 10.1021/acs.jmedchem.9b00711
Homo sapiens Progesterone receptor IC50 0.6 nM 10.1016/j.bmc.2010.04.092
Homo sapiens Progesterone receptor IC50 0.6 nM 10.1021/jm701080t
Homo sapiens Progesterone receptor IC50 1.4 nM 10.1016/j.bmcl.2006.11.062
Homo sapiens Progesterone receptor IC50 1.4 nM 10.1016/j.bmcl.2007.02.013
Homo sapiens Progesterone receptor IC50 1.4 nM 10.1016/j.bmcl.2009.01.095
Homo sapiens Progesterone receptor IC50 2.6 nM 10.1016/j.bmcl.2006.10.003
Homo sapiens Progesterone receptor IC50 2.9 nM 10.1016/j.bmcl.2004.06.021
Homo sapiens Progesterone receptor IC50 2.9 nM 10.1021/jm050205o
Homo sapiens Progesterone receptor IC50 3.0 nM 10.1016/j.bmcl.2004.02.048
Homo sapiens Progesterone receptor IC50 3.3 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor IC50 5.2 nM 10.1021/acsmedchemlett.8b00058
Homo sapiens Progesterone receptor IC50 7.943 nM 10.1021/jm100447c
Homo sapiens Progesterone receptor IC50 10.0 nM 10.1016/j.bmcl.2011.10.066
Homo sapiens Progesterone receptor Inhibition 98.0 % 10.1021/acs.jnatprod.8b00131
Homo sapiens Progesterone receptor Inhibition 100.0 % 10.1021/jm0105530
Homo sapiens Progesterone receptor Inhibition nan % 10.1021/acs.jmedchem.9b00711
Homo sapiens Progesterone receptor Inhibition nan % 10.1021/acsmedchemlett.6b00184
Homo sapiens Progesterone receptor Inhibition nan % 10.1021/acsmedchemlett.8b00058
Homo sapiens Progesterone receptor Ki 0.2512 nM 10.1016/j.bmcl.2005.05.001
Homo sapiens Progesterone receptor Ki 0.58 nM 10.1021/jm950747d
Homo sapiens Progesterone receptor Ki 0.64 nM 10.1021/jm0400045
Homo sapiens Progesterone receptor Ki 0.998 nM 10.1021/acs.jmedchem.5b00736
Homo sapiens Progesterone receptor Ki 1.1 nM 10.1016/s0960-894x(01)00554-6
Homo sapiens Progesterone receptor Ki 1.1 nM 10.1016/s0960-894x(03)00255-5
Homo sapiens Progesterone receptor Ki 1.1 nM 10.1016/s0960-894x(03)00256-7
Homo sapiens Progesterone receptor Ki 1.1 nM 10.1016/s0960-894x(98)00482-x
Homo sapiens Progesterone receptor Ki 1.1 nM 10.1021/jm9801915
Homo sapiens Progesterone receptor Ki 10.0 nM 10.1016/j.bmcl.2005.05.001
Homo sapiens Progesterone receptor Ki 10.0 nM 10.1016/j.bmcl.2006.04.055
Homo sapiens Progesterone receptor Ki 15.0 nM 10.1021/jm0105530
Homo sapiens Progesterone receptor Ki 15.0 nM 10.1021/jm501758q
Homo sapiens Progesterone receptor Kif 11.8 nM 10.1021/jm0105530
Homo sapiens Progesterone receptor %max 100.0 % 10.1016/j.bmcl.2006.04.055
Homo sapiens Progesterone receptor Max inhibition 83.0 % 10.1021/jm950747d
Homo sapiens Progesterone receptor Max inhibition 96.0 % 10.1021/jm950747d
Homo sapiens Progesterone receptor NE nan None 10.1021/jm001000c
Homo sapiens Progesterone receptor RBA 530.0 None 10.1021/jm00401a015
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 8436.8 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 15003.0 nM None
Homo sapiens Retinoid X receptor alpha Potency 14125.4 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 17782.8 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 25118.9 nM None
Homo sapiens Runt-related transcription factor 1/Core-binding factor subunit beta Potency 35481.3 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 11668.1 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 23280.9 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SH-SY5Y Activity 50.0 % 10.1016/j.bmc.2019.03.022
Homo sapiens SH-SY5Y Potency 28183.8 nM None
Homo sapiens Sigma opioid receptor IC50 26280.0 nM None
Homo sapiens Sigma opioid receptor Ki 11047.0 nM None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 81.2 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 80.3 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 70.7 % 10.1021/jm300212s
Homo sapiens Sphingomyelin phosphodiesterase Activity 101.9 % 10.1021/jm070524a
Homo sapiens SUM149PT Activity nan None 10.1016/j.ejmech.2018.01.056
Homo sapiens SUM149PT IC50 15000.0 nM 10.1016/j.ejmech.2018.01.056
Homo sapiens SUM149PT Inhibition nan % 10.1016/j.ejmech.2018.01.056
Homo sapiens Survival motor neuron protein Potency 17782.8 nM None
Homo sapiens Survival motor neuron protein Potency 25118.9 nM None
Homo sapiens Survival motor neuron protein Potency 28183.8 nM None
Homo sapiens Thrombin AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid hormone receptor alpha Ki 1250.0 nM 10.1021/jm0400045
Homo sapiens Thyroid hormone receptor beta-1 Ki 2250.0 nM 10.1021/jm0400045
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine aminotransferase Inhibition 101.0 % 10.1021/jm0400045
Homo sapiens Tyrosine-protein kinase FYN IC50 21357.0 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 19952.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23109.3 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23715.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 28183.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 31622.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 33498.3 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 50118.7 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 3000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 28183.8 nM None
Homo sapiens Vitamin D receptor Potency 39810.7 nM None
Homo sapiens Vitamin D receptor Potency 56234.1 nM None
Influenza A virus Nonstructural protein 1 Potency 14125.4 nM None
Influenza A virus Nonstructural protein 1 Potency 56234.1 nM None
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 3.7 % 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae MIC 20000.0 nM 10.6019/CHEMBL4513161
Macaca fascicularis Cynomolgus monkey Activity 60.0 % 10.1021/jm701080t
Mesocricetus auratus Syrian golden hamster Activity 35.0 % 10.1021/acs.jmedchem.5b00736
Mesocricetus auratus Syrian golden hamster Inhibition 43.0 % 10.1021/acs.jmedchem.5b00736
Mus musculus 3T3-L1 Inhibition nan % 10.1021/acs.jmedchem.8b01693
Mus musculus Glucocorticoid receptor IC50 2.2 nM 10.1021/jm001000c
Mus musculus Glucocorticoid receptor NE nan None 10.1021/jm001000c
Mus musculus Mus musculus Activity 1.5 ng/ml 10.1016/j.bmcl.2006.08.034
Mus musculus Mus musculus Activity 39.5 g 10.1016/j.bmcl.2006.08.034
Mus musculus Mus musculus Activity 43.2 mg/dl 10.1016/j.bmcl.2006.08.034
Mus musculus Mus musculus Activity 147.5 mg/dl 10.1016/j.bmcl.2006.08.034
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.01.056
Mus musculus Mus musculus AUC 1.371 None 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus AUC 1.863 None 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus CL 115.0 mL.min-1.kg-1 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus Cmax 69.83 nM 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus Cmax 6510.71 nM 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus F 31.0 % 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus Inhibition nan % 10.1016/j.bmc.2010.04.092
Mus musculus Mus musculus Inhibition nan % 10.1021/acs.jmedchem.8b00743
Mus musculus Mus musculus T1/2 2.8 hr 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus T1/2 4.0 hr 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus Tmax 0.08 hr 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus Tmax 1.0 hr 10.1016/j.bmcl.2006.10.003
Mus musculus Mus musculus WEIGHT 41.7 g 10.1021/jm050205o
Mus musculus Mus musculus WEIGHT 48.2 g 10.1021/jm050205o
Mus musculus Mus musculus WEIGHT 51.2 g 10.1021/jm050205o
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 8912.5 nM None
Mus musculus P-glycoprotein 3 Kd 20000.0 nM 10.1016/s0960-894x(99)00636-8
Mus musculus Progesterone receptor Corpora lutea 13.4 None 10.1021/jm980190c
Mus musculus Progesterone receptor Implants 3.3 None 10.1021/jm980190c
Mus musculus Progesterone receptor No. pregnant/mated 3.0 None 10.1021/jm980190c
Mus musculus Progesterone receptor Pregnant 18.8 % 10.1021/jm980190c
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 555.0 nM None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus Activity nan None 10.1021/ml100220b
Plasmodium falciparum Plasmodium falciparum IC50 3981.07 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 6309.57 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum Potency 6745.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 11689.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 13459.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 14715.7 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 4.18 % 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 20.2 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor ED50 mg/animal/day 1.6 None 10.1021/jm001000c
Rattus norvegicus Androgen Receptor IC50 8.345 nM None
Rattus norvegicus Androgen Receptor Ki 5.563 nM None
Rattus norvegicus Androgen Receptor RBA 25.0 None 10.1021/jm00401a015
Rattus norvegicus Bile acid transporter IC50 nan nM 10.1016/j.bmcl.2004.06.022
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glucocorticoid receptor Activity 0.27 uM 10.1021/jm050205o
Rattus norvegicus Glucocorticoid receptor EC50 2.512 nM 10.1016/j.bmcl.2007.04.094
Rattus norvegicus Glucocorticoid receptor ED50 6.0 mg.kg-1 10.1016/S0960-894X(97)00397-1
Rattus norvegicus Glucocorticoid receptor ED50 mg/animal/day 1.1 None 10.1021/jm001000c
Rattus norvegicus Glucocorticoid receptor IC50 1.4 nM 10.1021/jm050205o
Rattus norvegicus Glucocorticoid receptor IC50 1.94 nM 10.1021/acs.jmedchem.5b00736
Rattus norvegicus Glucocorticoid receptor IC50 270.0 nM 10.1016/j.bmcl.2004.06.021
Rattus norvegicus Glucocorticoid receptor IC50 270.0 nM 10.1016/j.bmcl.2004.06.022
Rattus norvegicus Glucocorticoid receptor IC50 410.0 nM 10.1016/s0960-894x(03)00431-1
Rattus norvegicus Glucocorticoid receptor IC50 nan None 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Glucocorticoid receptor Inhibition 77.0 % 10.1021/jm0400045
Rattus norvegicus Glucocorticoid receptor RBA 106.0 None 10.1021/jm00401a015
Rattus norvegicus Glucocorticoid receptor RBA 173.0 None 10.1021/jm00401a015
Rattus norvegicus Glucocorticoid receptor RBA 280.0 None 10.1021/jm00401a015
Rattus norvegicus Glucocorticoid receptor RBA 300.0 None 10.1021/jm00401a015
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Inositol monophosphatase 1 Potency 11220.2 nM None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver microsomes Stability 70.0 % 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Mineralocorticoid receptor RBA 0.1 None 10.1021/jm00401a015
Rattus norvegicus Multidrug resistance protein 1a Activity nan None 10.1016/0014-5793(94)01186-9
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 7943.3 nM None
Rattus norvegicus PC-12 Activity 31.1 % 10.1016/j.ejmech.2014.05.061
Rattus norvegicus Peripheral myelin protein 22 Potency 36125.4 nM None
Rattus norvegicus Plasma PPB 95.6 % 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Progesterone receptor EC50 15.85 nM 10.1016/j.bmcl.2007.04.094
Rattus norvegicus Progesterone receptor ED50 0.3 mg.kg-1 10.1021/jm025555e
Rattus norvegicus Progesterone receptor ED50 1.7 mg.kg-1 10.1021/jm025555e
Rattus norvegicus Progesterone receptor IC50 3.5 nM 10.1016/0960-894X(95)00320-S
Rattus norvegicus Progesterone receptor RBA 100.0 None 10.1016/0960-894X(95)00320-S
Rattus norvegicus Rattus norvegicus Activity 80.1 % 10.1021/jm501758q
Rattus norvegicus Rattus norvegicus Activity 88.5 % 10.1021/jm501758q
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmcl.2015.10.097
Rattus norvegicus Rattus norvegicus ALB 37700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 40200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 303.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 340.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 374.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 384.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 386.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 417.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 61.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 62.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 63.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 67.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 67.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 84.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 91.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 107.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 85.0 ng.hr.mL-1 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Rattus norvegicus AUC 446.0 ng.hr.mL-1 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus AUC 1970.0 ng.hr.mL-1 10.1016/j.ejmech.2018.01.056
Rattus norvegicus Rattus norvegicus AUC 2420.0 ng.hr.mL-1 10.1016/j.ejmech.2018.01.056
Rattus norvegicus Rattus norvegicus AUC 3571.0 ng.hr.mL-1 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus AUC nan None 10.1021/acs.jmedchem.7b00162
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 130.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 143.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 145.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 148.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 543.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 646.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 680.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 688.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 713.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 860.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 193.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 246.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 250.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 268.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 371.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 411.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CL 61.67 mL.min-1.kg-1 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Rattus norvegicus Cmax 55.87 nM 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Rattus norvegicus Cmax 125.23 nM 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus Cmax 837.99 nM 10.1016/j.ejmech.2018.01.056
Rattus norvegicus Rattus norvegicus Cmax nan None 10.1021/acs.jmedchem.7b00162
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31830000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Cp 3.9 nmol/ml 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Rattus norvegicus CREAT 1.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.6 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Drug uptake 26.5 % 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Rattus norvegicus ED50 0.7 mg.kg-1 10.1021/jm701080t
Rattus norvegicus Rattus norvegicus Efficacy 130.0 % 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 14.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 37.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 48.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 6.4 % 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Rattus norvegicus GLUC 1483.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1543.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1606.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1701.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1705.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1710.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 31.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 31.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.32 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.73 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 124700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 125300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 130200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus IC50 4.6 mg kg-1 10.1016/j.bmcl.2009.01.095
Rattus norvegicus Rattus norvegicus ID50 2.1 mg.kg-1 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus Inhibition 77.0 % 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Rattus norvegicus Inhibition 77.0 % 10.1016/j.bmcl.2006.10.001
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/s0960-894x(02)00746-1
Rattus norvegicus Rattus norvegicus Inhibition 101.0 % 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Rattus norvegicus Inhibition 101.0 % 10.1016/j.bmcl.2006.10.001
Rattus norvegicus Rattus norvegicus Inhibition 104.0 % 10.1016/j.bmcl.2006.08.133
Rattus norvegicus Rattus norvegicus Inhibition 104.0 % 10.1016/j.bmcl.2006.10.001
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1021/acs.jmedchem.7b00162
Rattus norvegicus Rattus norvegicus Inhibitory dose 0.5 mg kg-1 10.1016/s0960-894x(02)00746-1
Rattus norvegicus Rattus norvegicus LDH 74.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 78.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 81.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 87.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 88.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 97.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 16.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 25.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6590.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 7739.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8049.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8343.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9937.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11144.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 84.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 94.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.17 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.32 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.37 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.97 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 384200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 394700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 395300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 398500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.13 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.57 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.32 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.58 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.83 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 22.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 75.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 82.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 98.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 116.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 151.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MRT 8.0 hr 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus NEUTLE 5.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 14.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 535.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 634.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 646.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 790.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 897.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1310.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 80.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 95.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 99.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 100.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 101.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1024330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1084000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1129670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1194670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1231500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1290330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 4.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.65 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.72 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.79 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.82 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 55300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4800000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 4910000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5080000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5360000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5500000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.17 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Reduction 50.0 % 10.1021/jm050205o
Rattus norvegicus Rattus norvegicus SODIUM 141.62 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.92 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.37 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 1.6 hr 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Rattus norvegicus T1/2 3.02 hr 10.1016/j.ejmech.2018.01.056
Rattus norvegicus Rattus norvegicus T1/2 5.56 hr 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus TIME 0.04703 hr 10.1021/jm501758q
Rattus norvegicus Rattus norvegicus TIME 0.05194 hr 10.1021/jm501758q
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tmax 3.38 hr 10.1016/j.ejmech.2018.01.056
Rattus norvegicus Rattus norvegicus Tmax 12.5 hr 10.1016/j.bmcl.2008.05.070
Rattus norvegicus Rattus norvegicus URATE 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 5.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 5.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 5.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 7.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Vdss 4.1 L.kg-1 10.1021/acs.jmedchem.8b00743
Rattus norvegicus Rattus norvegicus WBC 7300.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 8820.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10930.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11720.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 8912.5 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 15848.9 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 9200.0 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 5.7 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 12.92 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.07581 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 25100.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 25118.86 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -4.55 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.13 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.05 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.1807 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 11.2 % 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 20000.0 nM 10.6019/CHEMBL4513161
Sus scrofa Glucocorticoid receptor IC50 10.9 nM 10.1021/acs.jmedchem.8b00743
Sus scrofa Glucocorticoid receptor IC50 19.7 nM 10.1021/acs.jmedchem.8b00743
Trypanosoma brucei 6-phospho-1-fructokinase Potency 6.0 nM None
Trypanosoma brucei brucei (strain 927/4 GUTat10.1) Putative uncharacterized protein Potency 10000.0 nM None
Trypanosoma brucei brucei (strain 927/4 GUTat10.1) Putative uncharacterized protein Potency 28183.8 nM None
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
None ADMET Activity 0.017 g 10.1021/acs.jnatprod.1c01008
None ADMET Activity 0.021 g 10.1021/acs.jnatprod.1c01008
None ADMET Activity 1.2 g 10.1021/acs.jnatprod.1c01008
None ADMET Activity 29.0 g 10.1021/acs.jnatprod.1c01008
None ADMET Activity 198.2 mg/dl 10.1021/acs.jnatprod.1c01008
None ADMET Activity nan None 10.1128/aac.01416-07
None ADMET AUC 85.0 ng.hr.mL-1 10.1021/acs.jmedchem.9b00711
None ADMET CL 0.33 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 15.6 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 24.2 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 26.92 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 50.0 mL.min-1.kg-1 10.1124/dmd.105.006619
None ADMET CL 61.67 mL.min-1.kg-1 10.1021/acs.jmedchem.9b00711
None ADMET CL 79.0 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 92.5 mL.min-1.g-1 10.1016/j.bmcl.2011.10.066
None ADMET Cmax 55.87 nM 10.1021/acs.jmedchem.9b00711
None ADMET F 6.4 % 10.1021/acs.jmedchem.9b00711
None ADMET Inhibition 104.0 % 10.1021/jm0400045
None ADMET Level 0.84 mequiv/L 10.1021/jm050205o
None ADMET Level 1.5 mequiv/L 10.1021/jm050205o
None ADMET Level 1.8 nmol of pHB/min/mg of protein 10.1021/jm050205o
None ADMET Level 7.5 ng ml-1 10.1021/jm050205o
None ADMET Level 14.0 ng ml-1 10.1021/jm050205o
None ADMET Level 30.5 mg/gof liver 10.1021/jm050205o
None ADMET Level 141.0 mg dl-1 10.1021/jm050205o
None ADMET Level 170.0 mg dl-1 10.1021/jm050205o
None ADMET Level 310.0 units/mL 10.1021/jm050205o
None ADMET Level 366.0 mg dl-1 10.1021/jm050205o
None ADMET Level 1110.0 units/mL 10.1021/jm050205o
None ADMET PPB 99.85 % 10.6019/CHEMBL3301361
None ADMET T1/2 0.1 hr 10.1021/jm050205o
None ADMET T1/2 0.33 hr 10.1021/jm050205o
None ADMET T1/2 1.6 hr 10.1021/acs.jmedchem.9b00711
None ADMET T1/2 nan hr 10.1021/jm050205o
None ADMET Vdss 0.3 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 4.1 L.kg-1 10.1021/acs.jmedchem.9b00711
None ADMET Vdss 4.3 mL/min/kg 10.1124/dmd.105.006619
None ADMET Vdss 10.5 L.kg-1 10.1124/dmd.105.006619
None ADMET Vdss 32.5 L.kg-1 10.1124/dmd.105.006619
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 14.3 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 900.0 nM 10.1021/jm501676v
None NON-PROTEIN TARGET Potency 3981.1 nM None
None NON-PROTEIN TARGET Potency 5011.9 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
None NON-PROTEIN TARGET Potency 11220.2 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
None NON-PROTEIN TARGET Potency 21117.7 nM None
None No relevant target Solubility 1900.0 nM 10.6019/CHEMBL3301361
None No relevant target Solubility 3000.0 nM 10.1021/acs.jmedchem.9b00711
None No relevant target Solubility 5400.0 nM 10.1021/acs.jmedchem.9b00711
None No relevant target Solubility 6900.0 nM 10.1021/acs.jmedchem.7b01690
None No relevant target Solubility 1164000.0 nM 10.1021/acs.jmedchem.9b00711
None Unchecked Ac50 1.585 uM None
None Unchecked Ac50 1.778 uM None
None Unchecked Ac50 2.239 uM None
None Unchecked Ac50 2.818 uM None
None Unchecked Ac50 35.48 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked AC50 1584.9 nM None
None Unchecked AC50 1778.3 nM None
None Unchecked AC50 2238.7 nM None
None Unchecked AC50 2818.4 nM None
None Unchecked AC50 22520.0 nM None
None Unchecked AC50 35481.3 nM None
None Unchecked AC50 39820.0 nM None
None Unchecked Activity nan None 10.1016/j.ejmech.2018.01.056
None Unchecked Activity nan None 10.1021/acs.jnatprod.1c01008
None Unchecked Hepatotoxicity (acute) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.7 nM 10.1016/j.bmcl.2004.02.054
None Unchecked IC50 13.9 nM 10.1021/acs.jmedchem.8b00743
None Unchecked IC50 21.9 nM 10.1021/acs.jmedchem.8b00743
None Unchecked IC50 5922.0 nM None
None Unchecked IC50 16010.0 nM None
None Unchecked IC50 29049.0 nM None
None Unchecked IC50 nan None None
None Unchecked Inhibition 23.0 % 10.1021/acs.jnatprod.1c01008
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.8b01693
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.1c01008
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ka 4.0 10^6/M 10.1016/j.bmc.2008.01.053
None Unchecked Ki 5310.0 nM None
None Unchecked Ki 15559.0 nM None
None Unchecked Ki 25821.0 nM None
None Unchecked Ki nan None None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 15848.9 nM None
None Unchecked Potency 17782.8 nM None
None Unchecked Potency 18348.9 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Ratio 2.4 None 10.1021/jm501676v
None Unchecked Ratio 2.6 None 10.1016/j.bmcl.2006.10.003
None Unchecked Ratio 3.743 None 10.1093/toxsci/kft176
None Unchecked Ratio 5.4 None 10.1016/S0960-894X(97)00397-1
None Unchecked Ratio IC50 0.12 None 10.1021/acs.jmedchem.8b00743
None Unchecked Ratio IC50 0.9 None 10.1016/j.bmcl.2011.12.110
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmcl.2006.11.062
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmcl.2007.02.013
None Unchecked Ratio IC50 110.0 None 10.1016/j.bmcl.2007.08.064
None Unchecked Ratio IC50 nan None 10.1016/j.bmc.2021.116003
None Unchecked Selectivity ratio 34.0 None 10.1021/jm701080t

Metabolism Information