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name Structure Reference Source Properties Activities Metabolism

Duvoglustat

AlkaPlorer ID: AK007568

Synonym: None

IUPAC Name: (2R,3R,4R,5S)-2-(hydroxymethyl)piperidin-1-ium-3,4,5-triol

Structure

SMILES: OC[C@H]1[NH2+]C[C@H](O)[C@@H](O)[C@@H]1O

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InChI: InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/p+1/t3-,4+,5-,6-/m1/s1

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InChIKey: LXBIFEVIBLOUGU-JGWLITMVSA-O

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Taxillus chinensis Taxillus Loranthaceae Santalales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Bacillus Bacillidae Phasmatodea Insecta Arthropoda Metazoa Eukaryota
Bacillus subtilis Bacillus Bacillaceae Bacillales Bacilli Bacillota None Bacteria
Castanospermum australe Castanospermum Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cichorium intybus Cichorium Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Morus alba Morus Moraceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Bacillus amyloliquefaciens Bacillus Bacillaceae Bacillales Bacilli Bacillota None Bacteria
None None Moraceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Scutellaria baicalensis Scutellaria Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Aglaonema Araceae Alismatales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Xanthocercis zambesiaca Xanthocercis Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Scilla Hyacinthaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cinnamosma macrocarpa Cinnamosma Canellaceae Canellales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aspergillus aculeatus Aspergillus Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Morus mongolica Morus Moraceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Morus bombycis Morus Moraceae Rosales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 164.181

TPSA？: 97.53000000000002

MolLogP？: -3.992999999999998

Number of H-Donors: 5

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Agrobacterium tumefaciens Beta-glucosidase Ki 12000.0 nM 10.1016/j.bmcl.2006.01.095
Agrobacterium tumefaciens Beta-glucosidase Ki 12000.0 nM 10.1016/j.bmcl.2014.03.069
Aspergillus niger Alpha-galactosidase C Inhibition 50.0 % 10.1021/jm0495881
Bos taurus Alpha-galactosidase B Inhibition 20.0 % 10.1016/j.bmcl.2005.05.081
Bos taurus Alpha-glucosidase IC50 400.0 nM 10.1021/jm00048a006
Bos taurus Alpha-glucosidase IC50 21000.0 nM 10.1021/jm00048a006
Bos taurus Alpha-glucosidase IC50 300000.0 nM 10.1016/S0960-894X(01)80688-0
Bos taurus Alpha-glucosidase IC50 nan nM 10.1021/jm00048a006
Bos taurus Alpha-L-fucosidase 1 IC50 nan None 10.1016/j.ejmech.2021.113716
Bos taurus Alpha-L-fucosidase 1 Inhibition 1.0 % 10.1016/j.ejmech.2021.113716
Bos taurus Alpha-L-fucosidase 1 Inhibition 50.0 % 10.1016/j.bmc.2011.04.011
Bos taurus Alpha-L-fucosidase 1 Inhibition 50.0 % 10.1021/jm0495881
Bos taurus Alpha-L-fucosidase 1 Inhibition 50.0 % 10.1021/np020296h
Bos taurus Beta-galactosidase IC50 300000.0 nM 10.1021/jm00048a006
Bos taurus Beta-galactosidase IC50 1000000.0 nM 10.1039/C2MD20343J
Bos taurus Beta-galactosidase IC50 nan nM 10.1021/jm00048a006
Bos taurus Beta-galactosidase Inhibition 50.0 % 10.1016/j.bmc.2011.04.011
Bos taurus Beta-galactosidase Inhibition 50.0 % 10.1021/jm0495881
Bos taurus Beta-galactosidase Inhibition 50.0 % 10.1021/jm301304e
Bos taurus Beta-galactosidase Inhibition 50.0 % 10.1021/np020296h
Bos taurus Glucosylceramidase IC50 210000.0 nM 10.1021/jm301304e
Bos taurus Glucosylceramidase Inhibition 50.0 % 10.1016/j.bmc.2011.04.011
Caldicellulosiruptor saccharolyticus Beta-glucosidase A IC50 55000.0 nM 10.1016/j.bmcl.2004.09.086
Caldicellulosiruptor saccharolyticus Beta-glucosidase A IC50 100000.0 nM 10.1021/np020296h
Caldicellulosiruptor saccharolyticus Beta-glucosidase A IC50 460000.0 nM 10.1021/jm00048a006
Caldicellulosiruptor saccharolyticus Beta-glucosidase A IC50 520000.0 nM 10.1021/jm00048a006
Caldicellulosiruptor saccharolyticus Beta-glucosidase A IC50 nan nM 10.1021/jm00048a006
Canavalia ensiformis Alpha-mannosidase Inhibition 17.4 % 10.1016/j.ejmech.2021.113716
Canavalia ensiformis Alpha-mannosidase Ki 270000.0 nM 10.1016/j.ejmech.2016.07.021
Coffea arabica Alpha-galactosidase IC50 23000.0 nM 10.1039/C2MD20343J
Coffea arabica Alpha-galactosidase IC50 nan None 10.1016/j.ejmech.2021.113716
Coffea arabica Alpha-galactosidase Inhibition 13.7 % 10.1016/j.ejmech.2021.113716
Equus caballus Cholinesterase IC50 10000.0 nM 10.1039/D1MD00217A
Escherichia coli K-12 Alpha-galactosidase Inhibition 20.0 % 10.1016/j.bmcl.2005.05.081
Escherichia coli (strain K12) Beta-glucuronidase IC50 nan None 10.1016/j.ejmech.2021.113716
Escherichia coli (strain K12) Beta-glucuronidase Inhibition 0.8 % 10.1016/j.ejmech.2021.113716
Geobacillus stearothermophilus Alpha-glucosidase IC50 1670.0 nM 10.1016/j.bmcl.2007.12.034
Glycine max Alpha-mannosidase Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens A549 IC50 10000.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens A549 IC50 1000000.0 nM 10.1016/j.bmcl.2010.09.065
Homo sapiens A549 Inhibition nan % 10.1016/j.bmcl.2010.09.065
Homo sapiens Alpha-galactosidase A Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens Alpha-galactosidase A Ki 18000.0 nM 10.1016/j.bmcl.2003.10.011
Homo sapiens Alpha-galactosidase A Potency 39810.7 nM None
Homo sapiens Alpha glucosidase IC50 39500.0 nM 10.1016/j.bmc.2017.12.043
Homo sapiens Alpha glucosidase IC50 192000.0 nM 10.1016/j.ejmech.2018.01.057
Homo sapiens Alpha glucosidase Inhibition nan % 10.1016/j.bmc.2017.12.043
Homo sapiens Alpha glucosidase Ki nan None 10.1016/j.bmc.2017.12.043
Homo sapiens Alpha-L-fucosidase I IC50 26000.0 nM 10.1021/jm00048a006
Homo sapiens Alpha-L-fucosidase I IC50 nan nM 10.1021/jm00048a006
Homo sapiens Alpha-L-fucosidase I Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens Alpha-L-fucosidase I Ki 100000000.0 nM 10.1016/S0960-894X(00)80649-6
Homo sapiens Beta-galactosidase Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens Beta-glucocerebrosidase Activity nan None 10.1021/jm1008902
Homo sapiens Beta-glucocerebrosidase Delta Tm -0.2 degrees C 10.1021/jm1008902
Homo sapiens Beta-glucocerebrosidase Delta Tm 0.72 degrees C 10.1021/jm1008902
Homo sapiens Beta-glucocerebrosidase Delta Tm 0.84 degrees C 10.1021/jm1008902
Homo sapiens Beta-glucocerebrosidase Delta Tm 1.79 degrees C 10.1021/jm1008902
Homo sapiens Beta-glucocerebrosidase Delta Tm 2.58 degrees C 10.1021/jm1008902
Homo sapiens Beta-glucocerebrosidase IC50 118000.0 nM 10.1016/S0960-894X(01)80688-0
Homo sapiens Beta-glucocerebrosidase IC50 195000.0 nM 10.1021/jm301304e
Homo sapiens Beta-glucocerebrosidase IC50 240000.0 nM 10.1016/j.bmc.2008.06.026
Homo sapiens Beta-glucocerebrosidase IC50 240000.0 nM 10.1016/j.ejmech.2022.114499
Homo sapiens Beta-glucocerebrosidase IC50 300000.0 nM 10.1016/S0960-894X(01)80688-0
Homo sapiens Beta-glucocerebrosidase IC50 500000.0 nM 10.1016/s0960-894x(00)00161-x
Homo sapiens Beta-glucocerebrosidase IC50 506000.0 nM 10.1016/j.bmc.2009.10.060
Homo sapiens Beta-glucocerebrosidase Inhibition 50.0 % 10.1016/j.bmc.2011.04.011
Homo sapiens Beta-glucocerebrosidase Ki 2000.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens Beta-glucocerebrosidase Ki 47000.0 nM 10.1016/s0960-894x(99)00042-6
Homo sapiens Beta-glucocerebrosidase Ki 79000.0 nM 10.1016/j.bmcl.2014.03.069
Homo sapiens Beta-glucocerebrosidase Ki 300000.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens Beta-glucocerebrosidase Potency 12589.3 nM None
Homo sapiens Beta-glucosidase IC50 20000.0 nM 10.1016/j.bmcl.2009.10.022
Homo sapiens Beta-glucosidase IC50 21000.0 nM 10.1021/jm901281m
Homo sapiens Beta-glucosidase IC50 28800.0 nM 10.1016/j.bmc.2009.10.060
Homo sapiens Beta-glucosidase IC50 30000.0 nM 10.1016/j.ejmech.2011.01.047
Homo sapiens Beta-glucosidase cytosolic IC50 80000.0 nM 10.1021/jm0495881
Homo sapiens Beta-glucosidase cytosolic IC50 240000.0 nM 10.1021/jm0495881
Homo sapiens Beta-mannosidase Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens BGC-823 IC50 10000.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens Ceramide glucosyltransferase IC50 100000.0 nM 10.1021/jm901281m
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 15848.9 nM None
Homo sapiens Epididymis-specific alpha-mannosidase Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens Fucosyltransferase 10 Relative activity 5.0 None 10.1016/S0960-894X(00)80270-X
Homo sapiens Glycogen debranching enzyme IC50 10000.0 nM 10.1021/jm901281m
Homo sapiens HCC1937 IC50 10000.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens HCT-116 IC50 10000.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens HepG2 Activity nan None 10.1016/j.ejmech.2017.02.007
Homo sapiens HepG2 IC50 10000.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens HUVEC IC50 2000.0 nM 10.1016/j.bmcl.2007.12.034
Homo sapiens Lactase-phlorizin hydrolase IC50 62000.0 nM 10.1021/jm901281m
Homo sapiens LXR-alpha IC50 100000.0 nM 10.1016/j.bmc.2008.02.078
Homo sapiens LXR-beta IC50 100000.0 nM 10.1016/j.bmc.2008.02.078
Homo sapiens Lysosomal alpha-glucosidase Activity 81.0 % 10.1021/acs.jmedchem.1c01673
Homo sapiens Lysosomal alpha-glucosidase FC 1.3 None 10.1021/jm301557k
Homo sapiens Lysosomal alpha-glucosidase FC 2.0 None 10.1021/jm301557k
Homo sapiens Lysosomal alpha-glucosidase FC 4.0 None 10.1021/jm301557k
Homo sapiens Lysosomal alpha-glucosidase IC50 60.0 nM 10.1016/j.bmc.2008.06.026
Homo sapiens Lysosomal alpha-glucosidase IC50 1000.0 nM 10.1016/j.bmc.2008.06.026
Homo sapiens Lysosomal alpha-glucosidase IC50 1500.0 nM 10.1016/j.bmcl.2009.10.022
Homo sapiens Lysosomal alpha-glucosidase IC50 1500.0 nM 10.1021/jm901281m
Homo sapiens Lysosomal alpha-glucosidase IC50 91900.0 nM 10.1016/S0960-894X(01)80688-0
Homo sapiens Lysosomal alpha-glucosidase IC50 nan nM 10.1016/S0960-894X(01)80688-0
Homo sapiens Lysosomal alpha-glucosidase Ki 59.0 nM 10.1021/acs.jmedchem.1c01673
Homo sapiens Lysosomal alpha-glucosidase Ki 150.0 nM 10.1016/S0960-894X(97)00012-7
Homo sapiens Lysosomal alpha-glucosidase Ki 25000.0 nM 10.1016/s0960-894x(99)00042-6
Homo sapiens Lysosomal alpha-glucosidase Potency 36.6 nM None
Homo sapiens Lysosomal alpha-glucosidase Potency 51.7 nM None
Homo sapiens Lysosomal alpha-glucosidase Potency 65.1 nM None
Homo sapiens Lysosomal alpha-glucosidase Potency 100.0 nM None
Homo sapiens Lysosomal alpha-mannosidase Inhibition 50.0 % 10.1021/jm0495881
Homo sapiens Maltase-glucoamylase IC50 40.0 nM 10.1021/jm0495881
Homo sapiens Maltase-glucoamylase IC50 360.0 nM 10.1021/jm00013a012
Homo sapiens Maltase-glucoamylase IC50 1400.0 nM 10.1016/j.ejmech.2021.113716
Homo sapiens Maltase-glucoamylase IC50 2000.0 nM 10.1021/jm901281m
Homo sapiens Maltase-glucoamylase IC50 8030.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens Maltase-glucoamylase Inhibition 100.0 % 10.1021/np060435l
Homo sapiens MCF7 Activity 0.409 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 1.19 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 1.75 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 19.0 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 31.41 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 49.59 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 78.4 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 Activity 96.6 % 10.1021/acs.jnatprod.1c00014
Homo sapiens MCF7 IC50 10000.0 nM 10.1021/acs.jnatprod.1c00014
Homo sapiens MOLT-4 CC50 100000.0 ug.mL-1 10.1021/jm00013a012
Homo sapiens MOLT-4 EC50 100000.0 ug.mL-1 10.1021/jm00013a012
Homo sapiens MS-1 IC50 2000.0 nM 10.1016/j.bmcl.2007.12.034
Homo sapiens MT4 CC50 100000.0 ug.mL-1 10.1021/jm00013a012
Homo sapiens MT4 EC50 100000.0 ug.mL-1 10.1021/jm00013a012
Homo sapiens Neutral alpha-glucosidase AB IC50 1300.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 25000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 210000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 320000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 500000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 570000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 1000000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB IC50 nan nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB Ki 14.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens Neutral alpha-glucosidase AB Ki 160.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens Neutral alpha-glucosidase AB Ki 21000.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens Neutral alpha-glucosidase AB Ki 23000.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens Neutral alpha-glucosidase AB Ki 410000.0 nM 10.1021/jm00048a006
Homo sapiens Neutral alpha-glucosidase AB Ki 460000.0 nM 10.1016/S0960-894X(00)80648-4
Homo sapiens PBMC Activity nan None 10.1016/j.bmcl.2011.10.081
Homo sapiens PBMC Inhibition 9.6 % 10.1016/j.bmcl.2011.10.081
Homo sapiens PBMC Inhibition nan % 10.1016/j.bmcl.2011.10.081
Homo sapiens Protein-tyrosine phosphatase 1B IC50 nan None 10.1016/j.bmc.2017.12.043
Homo sapiens Protein-tyrosine phosphatase 1B Inhibition nan % 10.1016/j.bmc.2017.12.043
Homo sapiens Protein-tyrosine phosphatase 1B Ki nan None 10.1016/j.bmc.2017.12.043
Homo sapiens Sucrase-isomaltase IC50 2000.0 nM 10.1021/jm901281m
Homo sapiens Sucrase-isomaltase Inhibition 95.0 % 10.1021/np980163p
Homo sapiens Trehalase IC50 40000.0 nM 10.1016/j.bmcl.2004.09.086
Homo sapiens Tyrosine-protein kinase JAK1 Inhibition nan % 10.1016/j.bmcl.2011.10.081
Mus musculus Lysosomal alpha-glucosidase EC50 98800.0 nM None
Mus musculus Mus musculus Activity nan None 10.1021/acs.jnatprod.9b00205
Mus musculus Mus musculus Activity nan None 10.1021/np970277l
Mus musculus Neutral alpha-glucosidase C IC50 300.0 nM 10.1021/jm00048a006
Mus musculus Neutral alpha-glucosidase C IC50 34000.0 nM 10.1021/jm00048a006
Mus musculus Neutral alpha-glucosidase C IC50 940000.0 nM 10.1021/jm00048a006
Mus musculus Neutral alpha-glucosidase C IC50 nan nM 10.1021/jm00048a006
Oryctolagus cuniculus Glycogen debranching enzyme IC50 190.0 nM 10.1016/j.bmc.2008.06.026
Oryza sativa Japonica Group Alpha-glucosidase IC50 30.0 nM 10.1021/jm0495881
Oryza sativa Japonica Group Alpha-glucosidase IC50 50.0 nM 10.1016/j.bmcl.2004.09.086
Prunus avium Beta-glucosidase IC50 81000.0 nM 10.1016/j.bmcl.2004.09.086
Prunus avium Beta-glucosidase Inhibition 50.0 % 10.1016/j.bmcl.2005.05.081
Prunus avium Beta-glucosidase Ki 9500.0 nM 10.1016/S0960-894X(01)81044-1
Rattus norvegicus Acidic alpha-glucosidase IC50 130.0 nM 10.1016/j.bmc.2008.06.026
Rattus norvegicus Acidic alpha-glucosidase IC50 360.0 nM 10.1021/jm00048a006
Rattus norvegicus Acidic alpha-glucosidase IC50 360.0 nM 10.1021/jm301304e
Rattus norvegicus Acidic alpha-glucosidase IC50 360.0 nM 10.1021/np020296h
Rattus norvegicus Acidic alpha-glucosidase IC50 400.0 nM 10.1021/jm00048a006
Rattus norvegicus Acidic alpha-glucosidase IC50 400.0 nM 10.1021/np020296h
Rattus norvegicus Acidic alpha-glucosidase IC50 25000.0 nM 10.1021/jm00048a006
Rattus norvegicus Acidic alpha-glucosidase IC50 150000.0 nM 10.1021/jm00048a006
Rattus norvegicus Acidic alpha-glucosidase IC50 560000.0 nM 10.1021/jm00048a006
Rattus norvegicus Acidic alpha-glucosidase IC50 1000000.0 nM 10.1021/jm00048a006
Rattus norvegicus Acidic alpha-glucosidase IC50 nan nM 10.1021/jm00048a006
Rattus norvegicus Alpha-mannosidase 2C1 IC50 50000.0 nM 10.1021/jm00013a012
Rattus norvegicus Beta-galactosidase IC50 27000.0 nM 10.1021/jm00048a006
Rattus norvegicus Beta-galactosidase IC50 30000.0 nM 10.1021/jm00048a006
Rattus norvegicus Beta-galactosidase IC50 390000.0 nM 10.1021/jm00048a006
Rattus norvegicus Beta-galactosidase IC50 500000.0 nM 10.1021/jm00048a006
Rattus norvegicus Beta-galactosidase IC50 nan nM 10.1021/jm00048a006
Rattus norvegicus Beta-galactosidase Inhibition 50.0 % 10.1021/jm0495881
Rattus norvegicus Beta-mannosidase Inhibition 50.0 % 10.1021/jm0495881
Rattus norvegicus Beta-mannosidase Inhibition 50.0 % 10.1021/np020296h
Rattus norvegicus Hepatocyte Inhibition 25.0 % 10.1016/j.bmc.2008.06.026
Rattus norvegicus Lactase-glycosylceramidase IC50 26000.0 nM 10.1021/jm00048a006
Rattus norvegicus Lactase-glycosylceramidase IC50 26000.0 nM 10.1021/jm301304e
Rattus norvegicus Lactase-glycosylceramidase IC50 34000.0 nM 10.1021/jm00013a012
Rattus norvegicus Lactase-glycosylceramidase IC50 49000.0 nM 10.1016/j.bmc.2011.04.011
Rattus norvegicus Mannosidase 2 alpha 1 IC50 50000.0 nM 10.1021/jm00013a012
Rattus norvegicus Mannosidase 2 alpha 1 Ki 50000.0 nM 10.1021/jm00013a012
Rattus norvegicus Mannosidase 2, alpha B1 IC50 1000000.0 nM 10.1021/jm00013a012
Rattus norvegicus Rattus norvegicus T1/2 0.08 hr 10.1016/S0960-894X(97)00012-7
Rattus norvegicus Sucrase-isomaltase IC50 160.0 nM 10.1016/j.bmc.2008.06.026
Rattus norvegicus Sucrase-isomaltase IC50 190.0 nM 10.1016/j.ejmech.2021.113716
Rattus norvegicus Sucrase-isomaltase IC50 210.0 nM 10.1016/j.bmc.2008.06.026
Rattus norvegicus Sucrase-isomaltase IC50 210.0 nM 10.1016/j.bmcl.2004.09.086
Rattus norvegicus Sucrase-isomaltase IC50 210.0 nM 10.1021/jm00013a012
Rattus norvegicus Sucrase-isomaltase IC50 210.0 nM 10.1021/jm301304e
Rattus norvegicus Sucrase-isomaltase IC50 300.0 nM 10.1016/j.bmcl.2004.09.086
Rattus norvegicus Sucrase-isomaltase IC50 300.0 nM 10.1021/jm00013a012
Rattus norvegicus Sucrase-isomaltase IC50 300.0 nM 10.1021/jm301304e
Rattus norvegicus Sucrase-isomaltase IC50 360.0 nM 10.1016/j.bmcl.2004.09.086
Rattus norvegicus Sucrase-isomaltase IC50 510.0 nM 10.1016/j.bmc.2011.04.011
Rattus norvegicus Sucrase-isomaltase IC50 610.0 nM 10.1016/j.ejmech.2021.113716
Rattus norvegicus Sucrase-isomaltase IC50 650.0 nM 10.1016/j.bmc.2011.04.011
Rattus norvegicus Sucrase-isomaltase IC50 650.0 nM 10.1021/jm0495881
Rattus norvegicus Sucrase-isomaltase Inhibition 100.0 % 10.1021/np980163p
Rattus norvegicus Sucrase-isomaltase Ki 24.0 nM 10.1016/S0960-894X(97)00012-7
Rattus norvegicus Trehalase IC50 41000.0 nM 10.1021/jm00048a006
Rattus norvegicus Trehalase IC50 42000.0 nM 10.1021/jm00013a012
Rattus norvegicus Trehalase IC50 42000.0 nM 10.1021/jm00048a006
Rattus norvegicus Trehalase IC50 42000.0 nM 10.1021/jm301304e
Rattus norvegicus Trehalase IC50 nan nM 10.1021/jm00048a006
Saccharomyces cerevisiae Alpha-glucosidase MAL62 IC50 110000.0 nM 10.1021/np010360f
Saccharomyces cerevisiae Alpha-glucosidase MAL62 IC50 278000.0 nM 10.1007/s00044-011-9699-9
Saccharomyces cerevisiae Alpha-glucosidase MAL62 IC50 425600000.0 nM 10.1016/j.ejmech.2013.01.036
Saccharomyces cerevisiae S288c Alpha-glucosidase IC50 26400.0 nM 10.1016/j.ejmech.2018.07.073
Saccharomyces cerevisiae S288c Alpha-glucosidase IC50 39500.0 nM 10.1016/j.ejmech.2018.07.073
Saccharomyces cerevisiae S288c Alpha-glucosidase IC50 68800.0 nM 10.1016/j.ejmech.2018.07.073
Saccharomyces cerevisiae S288c Alpha-glucosidase Inhibition 79.6 % 10.1016/j.ejmech.2018.07.073
Saccharomyces cerevisiae S288c Oligo-1,6-glucosidase IC50 330000.0 nM 10.1021/np020296h
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 7.57 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Activity nan None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.05 % 10.6019/CHEMBL4495565
Sus scrofa Uncharacterized protein IC50 41000.0 nM 10.1021/jm301304e
Sus scrofa Uncharacterized protein IC50 41000.0 nM 10.1021/np010360f
None ADMET Activity nan None 10.1016/j.bmc.2008.05.012
None ADMET IC50 25620.0 nM 10.1016/j.bmcl.2004.04.092
None ADMET T1/2 nan hr 10.1016/S0960-894X(97)00012-7
None NON-PROTEIN TARGET Inhibition 15.57 % 10.1016/j.bmc.2007.11.036
None No relevant target LogP -0.68 None 10.1021/acs.jnatprod.1c00014
None No relevant target pKa 6.5 None 10.1016/S0960-894X(00)80648-4
None T-cell Activity 2.53 % 10.1016/j.bmcl.2011.10.081
None T-cell IC50 25620.0 nM 10.1016/j.bmcl.2011.10.081
None Unchecked Activity nan None 10.1016/j.bmc.2008.02.078
None Unchecked Activity nan None 10.1016/j.bmc.2008.05.012
None Unchecked Activity nan None 10.1016/j.bmcl.2007.12.034
None Unchecked EC50 363900.0 nM 10.1021/acsmedchemlett.6b00332
None Unchecked FC 1.2 None 10.1021/acs.jmedchem.1c01673
None Unchecked FC 2.0 None 10.1021/jm301557k
None Unchecked IC50 30.0 nM 10.1016/j.bmc.2011.04.011
None Unchecked IC50 30.0 nM 10.1016/j.bmcl.2009.10.022
None Unchecked IC50 50.0 nM 10.1016/j.bmc.2016.11.053
None Unchecked IC50 50.0 nM 10.1016/j.ejmech.2016.09.095
None Unchecked IC50 50.0 nM 10.1021/np020296h
None Unchecked IC50 120.0 nM 10.1016/j.ejmech.2021.113716
None Unchecked IC50 270.0 nM 10.1016/j.ejmech.2021.113716
None Unchecked IC50 400.0 nM 10.1021/jm00013a012
None Unchecked IC50 440.0 nM 10.1016/j.ejmech.2021.113716
None Unchecked IC50 450.0 nM 10.1021/np9003883
None Unchecked IC50 500.0 nM 10.1016/j.bmcl.2009.10.022
None Unchecked IC50 650.0 nM 10.1016/j.bmc.2011.04.011
None Unchecked IC50 650.0 nM 10.1016/j.bmcl.2009.10.022
None Unchecked IC50 1400.0 nM 10.1021/acs.jmedchem.1c01673
None Unchecked IC50 1670.0 nM 10.1016/j.bmc.2008.05.012
None Unchecked IC50 4600.0 nM 10.1016/j.bmcl.2011.07.046
None Unchecked IC50 4600.0 nM 10.1021/jm00013a012
None Unchecked IC50 4600.0 nM 10.1021/jm00048a006
None Unchecked IC50 8200.0 nM 10.1016/j.bmcl.2009.05.125
None Unchecked IC50 11200.0 nM 10.1016/j.bmcl.2009.05.125
None Unchecked IC50 20600.0 nM 10.1016/j.bmc.2011.07.032
None Unchecked IC50 21260.0 nM 10.1016/j.ejmech.2016.02.044
None Unchecked IC50 21300.0 nM 10.1016/j.ejmech.2017.02.007
None Unchecked IC50 33000.0 nM 10.1039/C2MD20343J
None Unchecked IC50 35530.0 nM 10.1021/jm100757r
None Unchecked IC50 40000.0 nM 10.1016/j.bmc.2016.01.022
None Unchecked IC50 40000.0 nM 10.1016/j.ejmech.2011.06.003
None Unchecked IC50 42000.0 nM 10.1021/np010360f
None Unchecked IC50 47600.0 nM 10.1016/s0960-894x(00)00161-x
None Unchecked IC50 48000.0 nM 10.1016/j.ejmech.2021.113716
None Unchecked IC50 49290.0 nM 10.1016/j.bmcl.2008.01.055
None Unchecked IC50 50000.0 nM 10.1016/s0960-894x(03)00494-3
None Unchecked IC50 52000.0 nM 10.1016/j.bmc.2010.06.088
None Unchecked IC50 60300.0 nM 10.1016/j.bmc.2018.05.008
None Unchecked IC50 65180.0 nM 10.1039/c9md00559e
None Unchecked IC50 79000.0 nM 10.1021/acs.jnatprod.6b00766
None Unchecked IC50 80000.0 nM 10.1016/j.bmc.2011.04.011
None Unchecked IC50 85000.0 nM 10.1016/j.bmc.2016.11.053
None Unchecked IC50 109150.0 nM 10.1016/j.bmcl.2016.02.055
None Unchecked IC50 114900.0 nM 10.1021/acs.jnatprod.9b00283
None Unchecked IC50 167000.0 nM 10.1039/C2MD20343J
None Unchecked IC50 190000.0 nM 10.1016/j.bmcl.2004.09.086
None Unchecked IC50 203000.0 nM 10.1016/j.bmcl.2017.07.068
None Unchecked IC50 222000.0 nM 10.1021/np9003883
None Unchecked IC50 226912.0 nM 10.1016/j.bmc.2014.01.038
None Unchecked IC50 250000.0 nM 10.1016/j.bmc.2008.02.078
None Unchecked IC50 250000.0 nM 10.1016/j.bmcl.2009.10.022
None Unchecked IC50 250000.0 nM 10.1021/jm901281m
None Unchecked IC50 312000.0 nM 10.1039/C2MD20343J
None Unchecked IC50 327000.0 nM 10.1016/j.bmc.2011.04.011
None Unchecked IC50 327000.0 nM 10.1016/j.bmc.2016.11.053
None Unchecked IC50 422330.0 nM 10.1007/s00044-013-0838-3
None Unchecked IC50 425000.0 nM 10.1021/np800001v
None Unchecked IC50 425600.0 nM 10.1021/np050407n
None Unchecked IC50 426000.0 nM 10.1021/np800509u
None Unchecked IC50 520000.0 nM 10.1021/jm00013a012
None Unchecked IC50 520000.0 nM 10.1021/jm301304e
None Unchecked IC50 763000.0 nM 10.1016/j.ejmech.2021.113716
None Unchecked IC50 850000.0 nM 10.1021/np020296h
None Unchecked IC50 880000.0 nM 10.1016/j.bmc.2011.04.011
None Unchecked IC50 880000.0 nM 10.1021/jm0495881
None Unchecked IC50 1000000.0 nM 10.1039/C2MD20343J
None Unchecked IC50 5600000.0 nM 10.1016/j.bmcl.2004.03.037
None Unchecked IC50 nan nM 10.1021/jm00048a006
None Unchecked IC50 nan None 10.1016/j.ejmech.2021.113716
None Unchecked Inhibition 0.0 % 10.1016/j.ejmech.2021.113716
None Unchecked Inhibition 4.6 % 10.1016/j.ejmech.2021.113716
None Unchecked Inhibition 4.8 % 10.1016/j.ejmech.2021.113716
None Unchecked Inhibition 12.1 % 10.1016/j.ejmech.2021.113716
None Unchecked Inhibition 36.8 % 10.1021/acs.jnatprod.9b00283
None Unchecked Inhibition 45.6 % 10.1016/j.ejmech.2021.113716
None Unchecked Inhibition 50.0 % 10.1016/j.bmc.2008.06.026
None Unchecked Inhibition 50.0 % 10.1016/j.bmc.2011.04.011
None Unchecked Inhibition 50.0 % 10.1016/j.ejmech.2017.02.007
None Unchecked Inhibition 52.52 % 10.1016/j.bmcl.2016.02.055
None Unchecked Inhibition 81.2 % 10.1016/j.ejmech.2018.07.073
None Unchecked Ka 210000.0 M-1 10.1016/s0960-894x(00)00161-x
None Unchecked Ki 250.0 nM 10.1039/c5md00376h
None Unchecked Ki 1300.0 nM 10.1021/jm00013a012
None Unchecked Ki 12000.0 nM 10.1016/j.bmcl.2010.05.084
None Unchecked Ki 25000.0 nM 10.1016/j.ejmech.2016.07.021
None Unchecked Ki 47000.0 nM 10.1016/j.ejmech.2016.07.021
None Unchecked Ki 167000.0 nM 10.1016/j.bmc.2009.10.060
None Unchecked Ki 14000000.0 nM 10.1038/nchembio.81
None Unchecked Ki nan None 10.1016/j.ejmech.2016.02.044
None Unchecked Log Kd -4.02 None 10.1021/jm0105833
None Unchecked Ratio 6.0 None 10.1016/S0960-894X(97)00012-7

Metabolism Information