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name Structure Reference Source Properties Activities Metabolism

Apomorphine

AlkaPlorer ID: AK007640

Synonym: None

IUPAC Name: (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol

Structure

SMILES: CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O

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InChI: InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1

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InChIKey: VMWNQDUVQKEIOC-CYBMUJFWSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 267.328

TPSA？: 43.7

MolLogP？: 2.8499000000000017

Number of H-Donors: 2

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 25118.9 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 39810.7 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 50118.7 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 56234.1 nM None
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Potency 25118.9 nM None
Bos taurus Bos taurus pD2 6.2 None 10.1021/jm00105a047
Bos taurus Bos taurus Relative activity 38.0 % 10.1021/jm00105a047
Bos taurus Bos taurus Relative to DA 38.0 % 10.1021/jm00060a004
Bos taurus Dopamine D2 receptor D-2 50.0 % 10.1021/jm00126a009
Bos taurus Dopamine D2 receptor Ki 200.0 nM 10.1021/jm00160a018
Bos taurus Dopamine receptor IC50 1.0 nM 10.1021/jm00350a021
Bos taurus Dopamine receptor IC50 4.0 nM 10.1021/jm00123a039
Bos taurus Dopamine receptor IC50 4.9 nM 10.1021/jm00350a021
Bos taurus Dopamine receptor IC50 5.0 nM 10.1021/jm00183a003
Bos taurus Dopamine receptor IC50 8.6 nM 10.1021/jm00350a021
Bos taurus Dopamine receptor IC50 15.0 nM 10.1021/jm00148a030
Bos taurus Dopamine receptor IC50 15.0 nM 10.1021/jm00381a017
Bos taurus Dopamine receptor IC50 100.0 nM 10.1021/jm00183a003
Bos taurus Dopamine receptor IC50 182.0 nM 10.1021/jm00123a039
Bos taurus Dopamine receptor IC50 830.0 nM 10.1021/jm00354a010
Bos taurus Dopamine receptor IC50 1350.0 nM 10.1021/jm00148a030
Bos taurus Dopamine receptor IC50 1350.0 nM 10.1021/jm00381a017
Bos taurus Dopamine receptor IC50 8700.0 nM 10.1021/jm00354a010
Bos taurus Dopamine receptor Ki 3.7 nM 10.1021/jm00168a040
Bos taurus Serum albumin Binding 2.1 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 3.0 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 3.4 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 4.0 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 4.4 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 4.8 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 5.9 M of drug (M of BSA)-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 3850.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 4848.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 6215.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 8238.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 8465.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 9063.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 9938.0 dpm mg-1 10.1021/jm50001a014
Bos taurus Serum albumin Binding 12693.0 dpm mg-1 10.1021/jm50001a014
Caenorhabditis elegans Cytoplasmic zinc-finger protein EC50 300000.0 nM None
Caenorhabditis elegans Zinc finger protein mex-5 EC50 3293.0 nM None
Canis lupus familiaris Canis familiaris Activity 92.0 mmHg 10.1021/jm00175a001
Canis lupus familiaris Canis familiaris Activity 109.5 mmHg 10.1021/jm00175a001
Canis lupus familiaris Canis familiaris Activity 128.9 beats min-1 10.1021/jm00175a001
Canis lupus familiaris Canis familiaris Activity 139.2 beats min-1 10.1021/jm00175a001
Canis lupus familiaris Canis familiaris Activity nan None 10.1021/jm00226a021
Canis lupus familiaris Canis familiaris ED50 0.07 mg.kg-1 10.1021/jm00354a010
Canis lupus familiaris Canis familiaris ED50 0.142 umol.kg-1 10.1021/jm00134a005
Canis lupus familiaris Canis familiaris Increase nan None 10.1021/jm00134a005
Canis lupus familiaris Canis familiaris Potency ratio 0.046 None 10.1021/jm00181a010
Canis lupus familiaris Canis familiaris TED 32.3 nM kg-1 10.1021/jm00136a012
Danio rerio Danio rerio Activity nan None 10.1038/nchembio.307
Escherichia coli K-12 Beta-lactamase AmpC Potency 15848.9 nM None
Felis catus Felis catus Activity nan None 10.1021/jm00181a010
Felis catus Felis catus Change -18.2 % 10.1021/jm00134a005
Felis catus Felis catus Change -11.5 % 10.1021/jm00134a005
Felis catus Felis catus Change -9.9 % 10.1021/jm00134a005
Felis catus Felis catus Dose range 0.032 uM kg-1 10.1021/jm00360a006
Felis catus Felis catus ED50 0.022 umol.kg-1 10.1021/jm00134a005
Felis catus Felis catus ED50 0.022 umol.kg-1 10.1021/jm00181a010
Felis catus Felis catus ED50 0.022 umol.kg-1 10.1021/jm00360a006
Felis catus Felis catus ED50 0.022 umol.kg-1 10.1021/jm00368a015
Felis catus Felis catus Heart rate -6.5 beats min-1 10.1021/jm00134a005
Felis catus Felis catus Heart rate -4.3 beats min-1 10.1021/jm00134a005
Felis catus Felis catus Heart rate 10.3 beats min-1 10.1021/jm00134a005
Felis catus Felis catus ID50 0.019 umol.kg-1 10.1021/jm00190a002
Felis catus Felis catus ID50 0.022 umol.kg-1 10.1021/jm00160a036
Felis catus Felis catus ID50 0.022 umol.kg-1 10.1021/jm00162a017
Felis catus Felis catus ID50 0.022 umol.kg-1 10.1021/jm00175a001
Felis catus Felis catus ID50 0.022 umol.kg-1 10.1021/jm00354a010
Felis catus Felis catus ID50 0.024 umol.kg-1 10.1021/jm00179a006
Felis catus Felis catus ID50 0.0348 umol.kg-1 10.1021/jm00158a036
Felis catus Felis catus ID50 0.035 umol.kg-1 10.1021/jm00129a029
Felis catus Felis catus ID50 0.103 umol.kg-1 10.1021/jm00349a019
Felis catus Felis catus MED 10.0 ug kg-1 10.1021/jm00128a044
Felis catus Felis catus Relative activity 1.0 None 10.1021/jm00179a006
Felis catus Felis catus Relative potency 1.0 None 10.1021/jm00134a005
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 1122.0 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 14125.4 nM None
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Potency 22334.2 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 3981.1 nM None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 670.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 35481.3 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 320.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 2371.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 3800.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 2700.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 3200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Amyloid-beta A4 protein Activity nan None 10.1016/j.bmc.2018.01.028
Homo sapiens Amyloid-beta A4 protein Inhibition 50.0 % 10.1016/j.bmc.2018.01.028
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2018.01.028
Homo sapiens Amyloid-beta A4 protein Retention_time 6.4 min 10.1016/j.bmc.2018.01.028
Homo sapiens Amyloid-beta A4 protein Retention_time 6.9 min 10.1016/j.bmc.2018.01.028
Homo sapiens Amyloid-beta A4 protein TIME 6.0 hr 10.1016/j.bmc.2018.01.028
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 501.2 nM None
Homo sapiens Ataxin-2 Potency 39810.7 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 6510.4 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 211500.0 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 390900.0 nM 10.1124/dmd.112.047068
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bromodomain adjacent to zinc finger domain protein 2B Potency 35481.3 nM None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cathepsin L IC50 59642.0 nM None
Homo sapiens Cellular tumor antigen p53 Potency 6309.6 nM None
Homo sapiens Cellular tumor antigen p53 Potency 25118.9 nM None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 23400.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 16833.6 nM None
Homo sapiens Chromobox protein homolog 1 Potency 44668.4 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 1500.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 1A2 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 2C19 AC50 10000.0 nM None
Homo sapiens Cytochrome P450 2C19 Potency 10000.0 nM None
Homo sapiens Cytochrome P450 2C9 AC50 31622.78 nM None
Homo sapiens Cytochrome P450 2C9 Potency 31622.8 nM None
Homo sapiens Cytochrome P450 2D6 AC50 12589.25 nM None
Homo sapiens Cytochrome P450 2D6 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 5011.87 nM None
Homo sapiens Cytochrome P450 3A4 Potency 5011.9 nM None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens DNA polymerase iota Potency 31622.8 nM None
Homo sapiens DNA polymerase iota Potency 50118.7 nM None
Homo sapiens Dopamine D1 and D2 receptor Potency ratio 6.0 None 10.1021/jm00174a002
Homo sapiens Dopamine D1 and D2 receptor Selectivity index 42.8 None 10.1021/jm00171a014
Homo sapiens Dopamine D1 receptor AC50 13.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 2900.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor Activity 89.0 % 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D1 receptor EC50 3.77 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor EC50 3.981 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor EC50 25.7 nM 10.1016/j.bmc.2013.05.014
Homo sapiens Dopamine D1 receptor EC50 52.0 nM 10.1016/j.bmc.2007.06.036
Homo sapiens Dopamine D1 receptor EC50 501.19 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor EC50 520.8 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor Emax 13.02 % 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor Emax 94.92 % 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor Intrinsic activity 85.0 % 10.1016/j.bmc.2007.06.036
Homo sapiens Dopamine D1 receptor Kd 680.0 nM 10.1021/jm950447w
Homo sapiens Dopamine D1 receptor Ki 4.6 nM 10.1021/ml1001689
Homo sapiens Dopamine D1 receptor Ki 72.0 nM 10.1016/j.bmc.2009.04.047
Homo sapiens Dopamine D1 receptor Ki 72.0 nM 10.1016/j.ejmech.2011.04.028
Homo sapiens Dopamine D1 receptor Ki 290.0 nM 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D1 receptor Ki 372.0 nM 10.1016/j.bmcl.2020.127053
Homo sapiens Dopamine D1 receptor Ki 492.0 nM 10.1016/j.bmc.2013.05.014
Homo sapiens Dopamine D1 receptor Ki 650.0 nM 10.1021/ml1001689
Homo sapiens Dopamine D1 receptor Ki 660.0 nM 10.1016/j.ejmech.2012.07.025
Homo sapiens Dopamine D1 receptor KL 206.0 nM 10.1021/jm950447w
Homo sapiens Dopamine D1 receptor Log 1/Kd -2.83 None 10.1021/jm950447w
Homo sapiens Dopamine D1 receptor log(Tau/KA) 41.5 None 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D1 receptor Potency 65.1 nM None
Homo sapiens Dopamine D1 receptor Potency 183.6 nM None
Homo sapiens Dopamine D1 receptor Potency 631.0 nM None
Homo sapiens Dopamine D2 receptor AC50 1542.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor Activity 1.0 None 10.1021/jm00047a010
Homo sapiens Dopamine D2 receptor Activity 75.0 % None
Homo sapiens Dopamine D2 receptor Activity 83.5 % 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D2 receptor EC50 1.585 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor EC50 1.61 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor EC50 1.7 nM 10.1039/C3MD00154G
Homo sapiens Dopamine D2 receptor EC50 1.8 nM 10.1021/jm060662k
Homo sapiens Dopamine D2 receptor EC50 4.0 nM 10.1016/j.bmc.2007.06.036
Homo sapiens Dopamine D2 receptor EC50 4.0 nM 10.1016/j.bmc.2013.05.014
Homo sapiens Dopamine D2 receptor EC50 5.8 nM 10.1021/jm030505a
Homo sapiens Dopamine D2 receptor EC50 5.8 nM 10.1021/jm060662k
Homo sapiens Dopamine D2 receptor EC50 10.0 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor EC50 10.1 nM 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor EC50 12.7 nM 10.1016/j.bmcl.2018.04.059
Homo sapiens Dopamine D2 receptor EC50 20.0 nM 10.1016/j.bmcl.2007.10.059
Homo sapiens Dopamine D2 receptor EC50 575.44 nM None
Homo sapiens Dopamine D2 receptor Efficacy 86.0 % 10.1021/jm030505a
Homo sapiens Dopamine D2 receptor Efficacy 86.0 % 10.1021/jm060662k
Homo sapiens Dopamine D2 receptor Efficacy 91.0 % 10.1021/jm060662k
Homo sapiens Dopamine D2 receptor Emax 1.0 % 10.1016/j.bmcl.2018.04.059
Homo sapiens Dopamine D2 receptor Emax 60.0 % 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor Emax 75.0 % 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor Emax 91.0 % 10.1021/jm901689v
Homo sapiens Dopamine D2 receptor Emax 128.0 % 10.1039/C3MD00154G
Homo sapiens Dopamine D2 receptor IC50 4.2 nM 10.1016/j.ejmech.2014.12.045
Homo sapiens Dopamine D2 receptor IC50 117.0 nM 10.1039/C3MD00154G
Homo sapiens Dopamine D2 receptor Intrinsic activity 73.0 % 10.1021/jm00060a014
Homo sapiens Dopamine D2 receptor Intrinsic activity 73.0 % 10.1021/jm00060a015
Homo sapiens Dopamine D2 receptor Intrinsic activity 100.0 % 10.1016/j.bmc.2007.06.036
Homo sapiens Dopamine D2 receptor Kd 0.66 nM 10.1021/jm00126a009
Homo sapiens Dopamine D2 receptor Kd 24.0 nM 10.1021/jm950447w
Homo sapiens Dopamine D2 receptor Kd 127.0 nM 10.1021/jm00126a009
Homo sapiens Dopamine D2 receptor Ki 0.62 nM 10.1021/jm901689v
Homo sapiens Dopamine D2 receptor Ki 3.6 nM 10.1021/jm060662k
Homo sapiens Dopamine D2 receptor Ki 26.0 nM 10.1021/jm00060a014
Homo sapiens Dopamine D2 receptor Ki 26.0 nM 10.1021/jm00060a015
Homo sapiens Dopamine D2 receptor Ki 28.0 nM 10.1021/jm00047a010
Homo sapiens Dopamine D2 receptor Ki 32.0 nM 10.1016/j.bmc.2008.02.038
Homo sapiens Dopamine D2 receptor Ki 41.6 nM 10.1016/s0960-894x(00)00655-7
Homo sapiens Dopamine D2 receptor Ki 41.6 nM 10.1021/jm9911433
Homo sapiens Dopamine D2 receptor Ki 41.9 nM 10.1021/jm00004a011
Homo sapiens Dopamine D2 receptor Ki 41.9 nM 10.1021/jm0108505
Homo sapiens Dopamine D2 receptor Ki 41.9 nM 10.1021/jm960188q
Homo sapiens Dopamine D2 receptor Ki 41.9 nM 10.1021/jm960189i
Homo sapiens Dopamine D2 receptor Ki 42.0 nM 10.1016/j.ejmech.2019.01.031
Homo sapiens Dopamine D2 receptor Ki 42.0 nM 10.1016/j.ejmech.2019.07.027
Homo sapiens Dopamine D2 receptor Ki 50.0 nM 10.1016/j.ejmech.2012.07.025
Homo sapiens Dopamine D2 receptor Ki 53.0 nM 10.1016/j.bmc.2013.05.014
Homo sapiens Dopamine D2 receptor Ki 82.0 nM 10.1016/j.bmcl.2020.127053
Homo sapiens Dopamine D2 receptor Ki 98.0 nM 10.1016/j.bmc.2008.05.077
Homo sapiens Dopamine D2 receptor Ki 217.0 nM 10.1021/jm00043a013
Homo sapiens Dopamine D2 receptor Ki 244.0 nM 10.1021/jm901689v
Homo sapiens Dopamine D2 receptor KL 127.0 nM 10.1021/jm950447w
Homo sapiens Dopamine D2 receptor log(Tau/KA) 2.16 None 10.1021/acsmedchemlett.9b00575
Homo sapiens Dopamine D2 receptor %max 97.0 % 10.1039/C3MD00154G
Homo sapiens Dopamine D2 receptor Ratio Ki 393.0 None 10.1021/jm901689v
Homo sapiens Dopamine D3 receptor AC50 330.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor EC50 7.0 nM 10.1016/j.bmcl.2007.10.059
Homo sapiens Dopamine D3 receptor Ki 2.6 nM 10.1021/ml1001689
Homo sapiens Dopamine D3 receptor Ki 7.8 nM 10.1021/jm00047a010
Homo sapiens Dopamine D3 receptor Ki 10.0 nM 10.1016/j.ejmech.2012.07.025
Homo sapiens Dopamine D3 receptor Ki 17.0 nM 10.1016/j.bmc.2013.05.014
Homo sapiens Dopamine D3 receptor Potency 1412.5 nM None
Homo sapiens Dopamine D4 receptor EC50 4.3 nM 10.1021/jm030505a
Homo sapiens Dopamine D4 receptor EC50 4.3 nM 10.1021/jm060662k
Homo sapiens Dopamine D4 receptor Efficacy 84.0 % 10.1021/jm030505a
Homo sapiens Dopamine D4 receptor Efficacy 84.0 % 10.1021/jm060662k
Homo sapiens Dopamine D4 receptor Ki 8.9 nM 10.1021/jm060662k
Homo sapiens Dopamine D5 receptor Ki 15.0 nM 10.1016/j.bmcl.2020.127053
Homo sapiens Dopamine receptor AD50 nan None 10.1021/jm00160a036
Homo sapiens Dopamine receptor IC50 25.0 nM 10.1021/jm00372a019
Homo sapiens Dopamine receptor ID50 0.039 uM 10.1021/jm00382a024
Homo sapiens Dopamine receptor pKa 7.58 None 10.1021/jm00381a022
Homo sapiens Dopamine receptor Total binding inhibited 35.0 % 10.1021/jm00372a019
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 20.0 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 25118.9 nM None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 1470.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Flap endonuclease 1 Potency 23778.1 nM None
Homo sapiens Flap endonuclease 1 Potency 79432.8 nM None
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 6513.1 nM None
Homo sapiens Geminin Potency 11885.6 nM None
Homo sapiens Geminin Potency 25929.0 nM None
Homo sapiens Geminin Potency 33498.3 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glutaminase kidney isoform, mitochondrial Potency 12589.3 nM None
Homo sapiens Glutaminase kidney isoform, mitochondrial Potency 19952.6 nM None
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 2398.83 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens Histamine H1 receptor AC50 15000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 1412.5 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 1888.8 nM None
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 0.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Vdss 2.0 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 23109.3 nM None
Homo sapiens Kappa opioid receptor AC50 19418.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Lysine-specific demethylase 4A Potency 39810.7 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 35481.3 nM None
Homo sapiens Lysosomal alpha-glucosidase Potency 12589.3 nM None
Homo sapiens MAP kinase ERK2 Potency 31622.8 nM None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens microRNA 21 Potency 16481.6 nM None
Homo sapiens Microtubule-associated protein tau Potency 17782.8 nM None
Homo sapiens Microtubule-associated protein tau Potency 19952.6 nM None
Homo sapiens Microtubule-associated protein tau Potency 22387.2 nM None
Homo sapiens Microtubule-associated protein tau Potency 31622.8 nM None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 35481.3 nM None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens M-phase phosphoprotein 8 Potency 21192.3 nM None
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 20000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens p53-binding protein Mdm-2 IC50 195.0 nM 10.1016/j.bmcl.2017.03.082
Homo sapiens p53-binding protein Mdm-2 IC50 215.0 nM 10.1016/j.bmcl.2017.03.082
Homo sapiens p53-binding protein Mdm-2 IC50 30000.0 nM 10.1016/j.bmcl.2017.03.082
Homo sapiens p53-binding protein Mdm-2 Inhibition nan % 10.1016/j.bmcl.2017.03.082
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 2200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 35481.3 nM None
Homo sapiens Progesterone receptor AC50 25999.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Pyruvate kinase isozymes M1/M2 Potency 31622.8 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 94.7 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 37685.8 nM None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 5300.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 6641.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 117.0 nM 10.1016/j.bmcl.2020.127053
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 296.0 nM 10.1016/s0960-894x(00)00655-7
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 296.0 nM 10.1021/jm0108505
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 296.0 nM 10.1021/jm9911433
Homo sapiens Serotonin 1a (5-HT1a) receptor Ki 534.0 nM 10.1021/jm00084a013
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 964.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 1788.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor Activity 75.0 % None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 120.0 nM 10.1016/j.bmcl.2020.127053
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None 10.1016/j.ejmech.2019.01.031
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None 10.1016/j.ejmech.2019.07.027
Homo sapiens Serotonin 2a (5-HT2a) receptor pEC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 1268.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 4700.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 7300.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor Activity 75.0 % None
Homo sapiens Serotonin 2c (5-HT2c) receptor pEC50 nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None 10.1016/j.ejmech.2019.01.031
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None 10.1016/j.ejmech.2019.07.027
Homo sapiens Serotonin 7 (5-HT7) receptor Ki nan None 10.1016/j.ejmech.2019.01.031
Homo sapiens Serotonin 7 (5-HT7) receptor Ki nan None 10.1016/j.ejmech.2019.07.027
Homo sapiens Serotonin transporter AC50 21901.8 nM 10.1038/s41467-023-40064-9
Homo sapiens SH-SY5Y Potency 39810.7 nM None
Homo sapiens Sigma opioid receptor IC50 10000.0 nM 10.1021/jm00103a005
Homo sapiens Sigma opioid receptor IC50 31000.0 nM 10.1021/jm00103a005
Homo sapiens Solute carrier family 22 member 1 IC50 20800.0 nM 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Inhibition 69.0 % 10.1021/jm8003152
Homo sapiens Sulfotransferase 1A1 Activity nan None None
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 281.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 1883.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2985.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3758.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5956.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 17782.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 19952.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 20596.2 nM None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 2818.4 nM None
Homo sapiens Vitamin D receptor Potency 10000.0 nM None
Homo sapiens Vitamin D receptor Potency 35481.3 nM None
Leishmania mexicana Pyruvate kinase Potency 3162.3 nM None
Mus musculus Dopamine D1 receptor Ki 101.0 nM 10.1016/j.bmc.2008.02.038
Mus musculus Mus musculus Accumulation 0.561 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 1.42 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 2.84 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 7.51 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 20.0 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 21.4 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 23.1 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 56.9 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 57.3 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Accumulation 69.6 ug ml-1 10.1021/jm50001a014
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2011.07.022
Mus musculus Mus musculus Activity nan None 10.1021/jm00190a002
Mus musculus Mus musculus Activity nan None 10.1021/jm00223a006
Mus musculus Mus musculus Amount 0.065 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.107 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.245 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.331 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.38 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.394 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.558 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 0.99 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 1.48 % 10.1021/jm50001a014
Mus musculus Mus musculus Amount 4.01 % 10.1021/jm50001a014
Mus musculus Mus musculus Binding 0.68 ug g-1 10.1021/jm50001a014
Mus musculus Mus musculus Binding 0.94 ug g-1 10.1021/jm50001a014
Mus musculus Mus musculus Binding 0.98 ug g-1 10.1021/jm50001a014
Mus musculus Mus musculus Binding 1.13 ug g-1 10.1021/jm50001a014
Mus musculus Mus musculus Binding 1.62 % 10.1021/jm50001a014
Mus musculus Mus musculus Binding 1.65 % 10.1021/jm50001a014
Mus musculus Mus musculus Binding 1.71 % 10.1021/jm50001a014
Mus musculus Mus musculus Binding 2.88 % 10.1021/jm50001a014
Mus musculus Mus musculus ED50 0.021 mg.kg-1 10.1021/jm00163a068
Mus musculus Mus musculus ED50 0.3 mg.kg-1 10.1021/jm00163a068
Mus musculus Mus musculus ED50 0.36 mg.kg-1 10.1021/jm00047a010
Mus musculus Mus musculus ED50 0.7 mg.kg-1 10.1021/jm00139a027
Mus musculus Mus musculus ED50 6.4 mg.kg-1 10.1021/jm00105a039
Mus musculus Mus musculus ED50 6.9 mg.kg-1 10.1021/jm00113a010
Mus musculus Mus musculus ED50 30.0 mg.kg-1 10.1021/jm00105a039
Mus musculus Mus musculus ED50 nan mg.kg-1 10.1021/jm00123a004
Mus musculus Mus musculus Locomotor activity 22.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 22.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 42.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 42.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 52.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 52.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 66.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 66.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 69.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 69.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 73.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 73.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 78.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 78.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 86.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 86.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 96.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 96.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 113.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 113.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 119.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 119.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 135.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 135.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 139.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 139.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 150.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 150.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 1184.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 1184.0 None 10.1021/jm00060a015
Mus musculus Mus musculus Locomotor activity 1777.0 None 10.1021/jm00060a014
Mus musculus Mus musculus Locomotor activity 1777.0 None 10.1021/jm00060a015
Mus musculus Mus musculus MED 0.05 mg kg-1 10.1021/jm00123a004
Mus musculus Mus musculus Net turns/min 2.6 None 10.1021/jm00343a010
Mus musculus Mus musculus Permeability nan None 10.1021/jm990968+
Mus musculus Mus musculus Ratio 1.6 None 10.1021/jm50001a014
Mus musculus Mus musculus Ratio 2.6 None 10.1021/jm50001a014
Mus musculus Mus musculus Ratio 2.7 None 10.1021/jm50001a014
Mus musculus Mus musculus Ratio 2.9 None 10.1021/jm50001a014
Mus musculus Mus musculus Ratio 3.0 None 10.1021/jm50001a014
Mus musculus Mus musculus Ratio 3.1 None 10.1021/jm50001a014
Mus musculus Mus musculus Ratio 9.7 None 10.1021/jm50001a014
Mus musculus Mus musculus TIME 0.08333 hr 10.1021/jm00200a003
Mus musculus Mus musculus TIME 0.2367 hr 10.1021/jm00200a003
Mus musculus Nuclear receptor ROR-gamma Potency 15848.9 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 22387.2 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 25118.9 nM None
Oryctolagus cuniculus Fructose-bisphosphate aldolase A Potency 158489.3 nM None
Oryctolagus cuniculus Oryctolagus cuniculus EC50 44.0 nM 10.1021/jm00155a024
Papio papio Papio papio Duration 30.0 min 10.1021/jm00139a027
Photinus pyralis Luciferin 4-monooxygenase Potency 11423.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 1510.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 1651.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 10417.9 nM None
Plasmodium falciparum 3D7 M18 aspartyl aminopeptidase IC50 3669.0 nM None
Rattus norvegicus Adenylate cyclase Cyclase stimulation 48.0 % 10.1021/jm00350a021
Rattus norvegicus Adenylate cyclase Stimulation nan None 10.1021/jm00144a014
Rattus norvegicus Adrenergic receptor alpha-1 IC50 7750.0 nM 10.1021/jm00148a030
Rattus norvegicus Adrenergic receptor alpha-1 IC50 7750.0 nM 10.1021/jm00381a017
Rattus norvegicus Adrenergic receptor alpha-2 IC50 63.0 nM 10.1021/jm00378a014
Rattus norvegicus Adrenergic receptor alpha-2 IC50 430.0 nM 10.1021/jm00148a030
Rattus norvegicus Adrenergic receptor alpha-2 IC50 430.0 nM 10.1021/jm00381a017
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 20400.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Dopamine D1 receptor IC50 238.0 nM 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Dopamine D1 receptor IC50 384.0 nM 10.1016/S0960-894X(00)80249-8
Rattus norvegicus Dopamine D1 receptor IC50 384.0 nM 10.1016/S0960-894X(01)80462-5
Rattus norvegicus Dopamine D1 receptor IC50 384.0 nM 10.1021/jm00113a010
Rattus norvegicus Dopamine D1 receptor IC50 384.0 nM 10.1021/jm00163a051
Rattus norvegicus Dopamine D1 receptor IC50 430.0 nM 10.1016/s0960-894x(01)00076-2
Rattus norvegicus Dopamine D1 receptor IC50 432.0 nM 10.1021/jm00164a022
Rattus norvegicus Dopamine D1 receptor IC50 444.0 nM 10.1021/jm00174a002
Rattus norvegicus Dopamine D1 receptor IC50 3000.0 nM 10.1021/jm00171a014
Rattus norvegicus Dopamine D1 receptor Ki 53.0 nM 10.1021/jm00160a018
Rattus norvegicus Dopamine D1 receptor Ki 181.97 nM 10.1021/jm991034o
Rattus norvegicus Dopamine D1 receptor Ki 210.0 nM 10.1021/jm060959i
Rattus norvegicus Dopamine D1 receptor Ki 221.0 nM 10.1021/jm00047a010
Rattus norvegicus Dopamine D1 receptor Ki 236.0 nM 10.1021/jm00004a011
Rattus norvegicus Dopamine D1 receptor Ki 236.0 nM 10.1021/jm00168a040
Rattus norvegicus Dopamine D1 receptor Ki 236.0 nM 10.1021/jm960188q
Rattus norvegicus Dopamine D1 receptor Ki 236.0 nM 10.1021/jm960189i
Rattus norvegicus Dopamine D1 receptor Ki 888.0 nM 10.1021/jm00127a005
Rattus norvegicus Dopamine D1 receptor Ki 1010.0 nM 10.1021/jm701045j
Rattus norvegicus Dopamine D2 receptor Control 85.0 % 10.1021/jm00105a047
Rattus norvegicus Dopamine D2 receptor EC50 0.4 nM 10.1021/jm030505a
Rattus norvegicus Dopamine D2 receptor EC50 0.4 nM 10.1021/jm060662k
Rattus norvegicus Dopamine D2 receptor EC50 1.8 nM 10.1021/jm030505a
Rattus norvegicus Dopamine D2 receptor EC50 30.0 nM 10.1016/j.ejmech.2011.04.028
Rattus norvegicus Dopamine D2 receptor EC50 53.0 nM 10.1016/j.bmc.2009.04.047
Rattus norvegicus Dopamine D2 receptor ED50 0.051 mg.kg-1 10.1021/jm00100a006
Rattus norvegicus Dopamine D2 receptor ED50 0.13 mg.kg-1 10.1021/jm00100a006
Rattus norvegicus Dopamine D2 receptor Efficacy 58.0 % 10.1016/j.bmc.2009.04.047
Rattus norvegicus Dopamine D2 receptor Efficacy 91.0 % 10.1021/jm030505a
Rattus norvegicus Dopamine D2 receptor Efficacy 103.0 % 10.1021/jm030505a
Rattus norvegicus Dopamine D2 receptor Efficacy 103.0 % 10.1021/jm060662k
Rattus norvegicus Dopamine D2 receptor IC50 1.0 nM 10.1021/jm00402a036
Rattus norvegicus Dopamine D2 receptor IC50 1.7 nM 10.1016/S0960-894X(00)80249-8
Rattus norvegicus Dopamine D2 receptor IC50 1.7 nM 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Dopamine D2 receptor IC50 2.6 nM 10.1021/jm00163a051
Rattus norvegicus Dopamine D2 receptor IC50 2.6 nM 10.1021/jm00163a068
Rattus norvegicus Dopamine D2 receptor IC50 5.1 nM 10.1021/jm980212v
Rattus norvegicus Dopamine D2 receptor IC50 21.0 nM 10.1021/jm00164a022
Rattus norvegicus Dopamine D2 receptor IC50 24.0 nM 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Dopamine D2 receptor IC50 24.0 nM 10.1021/jm00113a010
Rattus norvegicus Dopamine D2 receptor IC50 24.1 nM 10.1016/S0960-894X(00)80249-8
Rattus norvegicus Dopamine D2 receptor IC50 24.1 nM 10.1016/S0960-894X(01)80462-5
Rattus norvegicus Dopamine D2 receptor IC50 27.0 nM 10.1021/jm00163a051
Rattus norvegicus Dopamine D2 receptor IC50 27.0 nM 10.1021/jm00163a068
Rattus norvegicus Dopamine D2 receptor IC50 66.7 nM 10.1021/jm00174a002
Rattus norvegicus Dopamine D2 receptor IC50 70.0 nM 10.1021/jm00171a014
Rattus norvegicus Dopamine D2 receptor IC50 118.0 nM 10.1007/s00044-004-0006-x
Rattus norvegicus Dopamine D2 receptor IC50 135.0 nM 10.1007/s00044-004-0006-x
Rattus norvegicus Dopamine D2 receptor IC50 220.0 nM 10.1016/s0960-894x(01)00076-2
Rattus norvegicus Dopamine D2 receptor IC50 302.0 nM 10.1021/jm00105a029
Rattus norvegicus Dopamine D2 receptor Kd 200.0 nM 10.1021/jm990526y
Rattus norvegicus Dopamine D2 receptor Kd 600.0 nM 10.1021/jm990526y
Rattus norvegicus Dopamine D2 receptor Kd 1200.0 nM 10.1021/jm990526y
Rattus norvegicus Dopamine D2 receptor Kd 1600.0 nM 10.1021/jm990526y
Rattus norvegicus Dopamine D2 receptor Ki 1.8 nM 10.1021/ml1001689
Rattus norvegicus Dopamine D2 receptor Ki 1.9 nM 10.1021/jm701045j
Rattus norvegicus Dopamine D2 receptor Ki 2.2 nM 10.1021/jm00047a010
Rattus norvegicus Dopamine D2 receptor Ki 11.1 nM 10.1016/j.bmc.2008.02.038
Rattus norvegicus Dopamine D2 receptor Ki 11.1 nM 10.1021/jm00168a040
Rattus norvegicus Dopamine D2 receptor Ki 11.5 nM 10.1016/j.bmc.2009.04.047
Rattus norvegicus Dopamine D2 receptor Ki 11.5 nM 10.1016/j.ejmech.2011.04.028
Rattus norvegicus Dopamine D2 receptor Ki 13.0 nM 10.1021/jm060959i
Rattus norvegicus Dopamine D2 receptor Ki 17.3 nM 10.1021/jm00047a010
Rattus norvegicus Dopamine D2 receptor Ki 32.0 nM 10.1016/j.bmc.2008.02.038
Rattus norvegicus Dopamine D2 receptor Ki 46.0 nM 10.1021/jm00084a013
Rattus norvegicus Dopamine D2 receptor Ki 54.95 nM 10.1021/jm991034o
Rattus norvegicus Dopamine D2 receptor Ki 98.0 nM 10.1021/ml1001689
Rattus norvegicus Dopamine D2 receptor pD2 7.5 None 10.1021/jm00105a047
Rattus norvegicus Dopamine D2 receptor Receptor state nan None 10.1021/jm00100a006
Rattus norvegicus Dopamine D2 receptor Synaptic site nan None 10.1021/jm00100a006
Rattus norvegicus Dopamine D3 receptor IC50 27.2 nM 10.1007/s00044-004-0006-x
Rattus norvegicus Dopamine D3 receptor IC50 29.4 nM 10.1007/s00044-004-0006-x
Rattus norvegicus Dopamine D4 receptor EC50 1.5 nM 10.1021/jm030505a
Rattus norvegicus Dopamine D4 receptor EC50 5.5 nM 10.1021/jm030505a
Rattus norvegicus Dopamine D4 receptor EC50 5.5 nM 10.1021/jm060662k
Rattus norvegicus Dopamine D4 receptor Efficacy 84.0 % 10.1021/jm030505a
Rattus norvegicus Dopamine D4 receptor Efficacy 87.0 % 10.1021/jm030505a
Rattus norvegicus Dopamine D4 receptor Efficacy 87.0 % 10.1021/jm060662k
Rattus norvegicus Dopamine receptor ED50 0.14 mg.kg-1 10.1021/jm00378a014
Rattus norvegicus Dopamine receptor ED50 0.19 umol.kg-1 10.1021/jm00144a021
Rattus norvegicus Dopamine receptor ED50 0.19 umol.kg-1 10.1021/jm00160a017
Rattus norvegicus Dopamine receptor ED50 0.22 umol.kg-1 10.1021/jm00144a021
Rattus norvegicus Dopamine receptor ED50 0.22 umol.kg-1 10.1021/jm00160a017
Rattus norvegicus Dopamine receptor IC50 1.0 nM 10.1021/jm00144a014
Rattus norvegicus Dopamine receptor IC50 1.1 nM 10.1021/jm00378a014
Rattus norvegicus Dopamine receptor IC50 1.4 nM 10.1021/jm00346a007
Rattus norvegicus Dopamine receptor IC50 1.8 nM 10.1021/jm00346a007
Rattus norvegicus Dopamine receptor IC50 2.6 nM 10.1021/jm00398a032
Rattus norvegicus Dopamine receptor IC50 27.0 nM 10.1021/jm00105a039
Rattus norvegicus Dopamine receptor IC50 27.0 nM 10.1021/jm00398a032
Rattus norvegicus Dopamine receptor IC50 27.0 nM 10.1021/jm00403a022
Rattus norvegicus Dopamine receptor IC50 110.0 nM 10.1021/jm00386a009
Rattus norvegicus Dopamine receptor IC50 860.0 nM 10.1021/jm00144a014
Rattus norvegicus Dopamine receptor D2 and D3 IC50 24.3 nM 10.1007/s00044-004-0006-x
Rattus norvegicus Dopamine receptor D2 and D3 IC50 69.5 nM 10.1007/s00044-004-0006-x
Rattus norvegicus Dopamine receptors; D1 & D2 IC50 1.7 nM 10.1016/S0960-894X(01)80462-5
Rattus norvegicus Dopamine receptors; D1 & D2 Potency ratio 21.2 None 10.1021/jm00168a040
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Opioid receptor IC50 302.0 nM 10.1021/jm00393a037
Rattus norvegicus Peripheral myelin protein 22 Potency 14381.8 nM None
Rattus norvegicus Plasma logFu 0.5 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Rattus norvegicus Acc. counts 361.0 None 10.1021/jm00160a017
Rattus norvegicus Rattus norvegicus Accumulated counts/30 361.0 None 10.1021/jm00146a012
Rattus norvegicus Rattus norvegicus Accumulation 8.9 None 10.1021/jm00386a009
Rattus norvegicus Rattus norvegicus Accumulation counts 24.0 None 10.1021/jm00136a012
Rattus norvegicus Rattus norvegicus Accumulation counts 64.0 None 10.1021/jm00136a012
Rattus norvegicus Rattus norvegicus Accumulation counts nan None 10.1021/jm00380a012
Rattus norvegicus Rattus norvegicus Activity 0.8 None 10.1021/jm00402a024
Rattus norvegicus Rattus norvegicus Activity 9.7 None 10.1021/jm00402a024
Rattus norvegicus Rattus norvegicus Activity 12.7 None 10.1021/jm00402a024
Rattus norvegicus Rattus norvegicus Activity 17.5 None 10.1021/jm00402a024
Rattus norvegicus Rattus norvegicus Activity 20.0 % 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus Activity 20.2 % 10.1021/jm00362a005
Rattus norvegicus Rattus norvegicus Activity 34.2 % 10.1021/jm00362a005
Rattus norvegicus Rattus norvegicus Activity 37.0 % 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus Activity 50.0 % 10.1021/jm00362a005
Rattus norvegicus Rattus norvegicus Activity 52.0 % 10.1021/jm00387a004
Rattus norvegicus Rattus norvegicus Activity 53.0 % 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus Activity 65.0 % 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus Activity 72.4 % 10.1021/jm00362a005
Rattus norvegicus Rattus norvegicus Activity 77.0 % 10.1021/jm901689v
Rattus norvegicus Rattus norvegicus Activity 85.0 % 10.1021/jm060279f
Rattus norvegicus Rattus norvegicus Activity 91.0 % 10.1021/jm030505a
Rattus norvegicus Rattus norvegicus Activity 91.0 % 10.1021/jm060662k
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1021/jm00047a010
Rattus norvegicus Rattus norvegicus Activity 100.0 % 10.1021/jm00362a005
Rattus norvegicus Rattus norvegicus Activity 192.4 % 10.1021/jm00362a005
Rattus norvegicus Rattus norvegicus Activity 277.0 % 10.1021/jm00387a004
Rattus norvegicus Rattus norvegicus Activity 366.0 % 10.1021/jm00387a004
Rattus norvegicus Rattus norvegicus Activity 505.0 None 10.1021/jm00402a024
Rattus norvegicus Rattus norvegicus Activity 828.0 None 10.1021/jm00200a003
Rattus norvegicus Rattus norvegicus Activity 7118.0 % 10.1021/jm901689v
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00190a002
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00206a007
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00207a005
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00212a002
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm00226a021
Rattus norvegicus Rattus norvegicus Animals 100.0 % 10.1021/jm00105a039
Rattus norvegicus Rattus norvegicus Animals 100.0 % 10.1021/jm00163a051
Rattus norvegicus Rattus norvegicus Antagonism nan None 10.1021/jm00160a036
Rattus norvegicus Rattus norvegicus Behavior response nan None 10.1021/jm00129a029
Rattus norvegicus Rattus norvegicus Change -55.0 % 10.1021/jm00084a013
Rattus norvegicus Rattus norvegicus Change 4.0 % 10.1021/jm00084a013
Rattus norvegicus Rattus norvegicus CI 57.0 % 10.1021/jm00113a010
Rattus norvegicus Rattus norvegicus Control -55.0 % 10.1021/jm00060a014
Rattus norvegicus Rattus norvegicus Control -55.0 % 10.1021/jm00060a015
Rattus norvegicus Rattus norvegicus Control 17.0 % 10.1021/jm00060a014
Rattus norvegicus Rattus norvegicus Control 17.0 % 10.1021/jm00060a015
Rattus norvegicus Rattus norvegicus Control 18.3 % 10.1021/jm00349a019
Rattus norvegicus Rattus norvegicus Control 40.0 % 10.1021/jm00119a020
Rattus norvegicus Rattus norvegicus Control 48.0 % 10.1021/jm00119a020
Rattus norvegicus Rattus norvegicus Control 52.0 % 10.1021/jm00146a012
Rattus norvegicus Rattus norvegicus Control 56.0 % 10.1021/jm00384a038
Rattus norvegicus Rattus norvegicus Control 60.0 % 10.1021/jm00384a038
Rattus norvegicus Rattus norvegicus Control 75.0 % 10.1021/jm00159a011
Rattus norvegicus Rattus norvegicus Control 100.0 % 10.1021/jm00402a024
Rattus norvegicus Rattus norvegicus Control 277.0 % 10.1021/jm00146a012
Rattus norvegicus Rattus norvegicus Control nan None 10.1021/jm00349a019
Rattus norvegicus Rattus norvegicus DA utilization 4008.0 None 10.1021/jm00386a009
Rattus norvegicus Rattus norvegicus Decrease 100.0 % 10.1021/jm00163a068
Rattus norvegicus Rattus norvegicus Difference 44.0 % 10.1021/jm00386a009
Rattus norvegicus Rattus norvegicus Difference 63.0 % 10.1021/jm00386a009
Rattus norvegicus Rattus norvegicus DOPAC 1.73 None 10.1021/jm00403a007
Rattus norvegicus Rattus norvegicus DOPAC 2.33 None 10.1021/jm00403a007
Rattus norvegicus Rattus norvegicus DOPAC 2.97 None 10.1021/jm00403a007
Rattus norvegicus Rattus norvegicus Dose 2.3 uM kg-1 10.1021/jm00160a017
Rattus norvegicus Rattus norvegicus ED100 230.0 nM kg-1 10.1021/jm00136a012
Rattus norvegicus Rattus norvegicus ED200 0.005 mg kg-1 10.1021/jm00105a039
Rattus norvegicus Rattus norvegicus ED50 0.006 mg.kg-1 10.1021/jm00163a051
Rattus norvegicus Rattus norvegicus ED50 0.006 mg.kg-1 10.1021/jm00403a022
Rattus norvegicus Rattus norvegicus ED50 0.021 mg.kg-1 10.1021/jm00398a032
Rattus norvegicus Rattus norvegicus ED50 0.021 mg.kg-1 10.1021/jm00403a022
Rattus norvegicus Rattus norvegicus ED50 0.03 mg.kg-1 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Rattus norvegicus ED50 0.03 mg.kg-1 10.1021/jm00047a010
Rattus norvegicus Rattus norvegicus ED50 0.03 mg.kg-1 10.1021/jm00105a039
Rattus norvegicus Rattus norvegicus ED50 0.03 mg.kg-1 10.1021/jm00113a010
Rattus norvegicus Rattus norvegicus ED50 0.03 mg.kg-1 10.1021/jm00163a051
Rattus norvegicus Rattus norvegicus ED50 0.03 umol.kg-1 10.1021/jm00060a014
Rattus norvegicus Rattus norvegicus ED50 0.031 umol.kg-1 10.1021/jm00060a015
Rattus norvegicus Rattus norvegicus ED50 0.04 mg.kg-1 10.1021/jm00398a032
Rattus norvegicus Rattus norvegicus ED50 0.04 umol.kg-1 10.1021/jm00393a025
Rattus norvegicus Rattus norvegicus ED50 0.041 umol.kg-1 10.1021/jm00136a012
Rattus norvegicus Rattus norvegicus ED50 0.041 umol.kg-1 10.1021/jm00387a004
Rattus norvegicus Rattus norvegicus ED50 0.041 umol.kg-1 10.1021/jm00390a004
Rattus norvegicus Rattus norvegicus ED50 0.044 umol.kg-1 10.1021/jm00136a012
Rattus norvegicus Rattus norvegicus ED50 0.044 umol.kg-1 10.1021/jm00387a004
Rattus norvegicus Rattus norvegicus ED50 0.044 umol.kg-1 10.1021/jm00390a004
Rattus norvegicus Rattus norvegicus ED50 0.058 umol.kg-1 10.1021/jm00384a024
Rattus norvegicus Rattus norvegicus ED50 0.06 mg.kg-1 10.1021/jm00146a012
Rattus norvegicus Rattus norvegicus ED50 0.06 mg.kg-1 10.1021/jm00163a068
Rattus norvegicus Rattus norvegicus ED50 0.07 mg.kg-1 10.1021/jm00113a010
Rattus norvegicus Rattus norvegicus ED50 0.092 umol.kg-1 10.1021/jm00384a024
Rattus norvegicus Rattus norvegicus ED50 0.096 mg.kg-1 10.1021/jm00163a068
Rattus norvegicus Rattus norvegicus ED50 0.096 mg.kg-1 10.1021/jm00398a032
Rattus norvegicus Rattus norvegicus ED50 0.096 mg.kg-1 10.1021/jm00403a022
Rattus norvegicus Rattus norvegicus ED50 0.1 mg.kg-1 10.1021/jm00163a051
Rattus norvegicus Rattus norvegicus ED50 0.19 umol.kg-1 10.1021/jm00198a008
Rattus norvegicus Rattus norvegicus ED50 0.19 umol.kg-1 10.1021/jm00350a008
Rattus norvegicus Rattus norvegicus ED50 0.19 umol.kg-1 10.1021/jm00374a016
Rattus norvegicus Rattus norvegicus ED50 0.19 umol.kg-1 10.1021/jm00380a012
Rattus norvegicus Rattus norvegicus ED50 0.22 umol.kg-1 10.1021/jm00198a008
Rattus norvegicus Rattus norvegicus ED50 0.22 umol.kg-1 10.1021/jm00350a008
Rattus norvegicus Rattus norvegicus ED50 0.22 umol.kg-1 10.1021/jm00374a016
Rattus norvegicus Rattus norvegicus ED50 0.22 umol.kg-1 10.1021/jm00380a012
Rattus norvegicus Rattus norvegicus ED50 0.27 umol.kg-1 10.1021/jm00384a024
Rattus norvegicus Rattus norvegicus ED50 0.28 mg.kg-1 10.1021/jm00100a006
Rattus norvegicus Rattus norvegicus ED50 0.3 mg.kg-1 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Rattus norvegicus ED50 0.3 mg.kg-1 10.1021/jm00403a022
Rattus norvegicus Rattus norvegicus ED50 0.64 umol.kg-1 10.1021/jm00384a024
Rattus norvegicus Rattus norvegicus ED50 2.3 mg.kg-1 10.1021/jm00119a020
Rattus norvegicus Rattus norvegicus ED50 30.0 mg.kg-1 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Rattus norvegicus ED50 30.0 mg.kg-1 10.1021/jm00113a010
Rattus norvegicus Rattus norvegicus ED50 30.0 mg.kg-1 10.1021/jm00403a022
Rattus norvegicus Rattus norvegicus ED50 nan umol.kg-1 10.1021/jm00350a008
Rattus norvegicus Rattus norvegicus Effect 0.28 % 10.1021/jm00047a010
Rattus norvegicus Rattus norvegicus Effective dose 0.1 uM kg-1 10.1021/jm030505a
Rattus norvegicus Rattus norvegicus Hemispheres reduction nan None 10.1021/jm00350a008
Rattus norvegicus Rattus norvegicus HVA 0.91 None 10.1021/jm00403a007
Rattus norvegicus Rattus norvegicus HVA 1.14 None 10.1021/jm00403a007
Rattus norvegicus Rattus norvegicus HVA 1.59 None 10.1021/jm00403a007
Rattus norvegicus Rattus norvegicus IC50 22.6 nM 10.1021/jm00376a020
Rattus norvegicus Rattus norvegicus IC50 70.0 nM 10.1021/jm00368a015
Rattus norvegicus Rattus norvegicus IC50 1100.0 nM 10.1021/jm00368a015
Rattus norvegicus Rattus norvegicus ID50 0.058 mg.kg-1 10.1021/jm00148a030
Rattus norvegicus Rattus norvegicus ID50 0.081 mg.kg-1 10.1021/jm00148a030
Rattus norvegicus Rattus norvegicus ID50 0.23 umol.kg-1 10.1021/jm00207a005
Rattus norvegicus Rattus norvegicus ID50 10.0 mg.kg-1 10.1021/jm00148a030
Rattus norvegicus Rattus norvegicus ID50 10.0 mg.kg-1 10.1021/jm00381a017
Rattus norvegicus Rattus norvegicus ID50 nan mg.kg-1 10.1021/jm00381a017
Rattus norvegicus Rattus norvegicus Increase 100.0 % 10.1021/jm00163a068
Rattus norvegicus Rattus norvegicus Inhibition 29.0 % 10.1021/jm00211a017
Rattus norvegicus Rattus norvegicus Inhibition 29.0 % 10.1021/jm00223a016
Rattus norvegicus Rattus norvegicus Inhibition 85.0 % 10.1021/jm00060a004
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/S0960-894X(00)80249-8
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/S0960-894X(01)80462-5
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1016/S0960-894X(01)81245-2
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1021/jm00105a039
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1021/jm00113a010
Rattus norvegicus Rattus norvegicus Inhibition 100.0 % 10.1021/jm00403a022
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1021/jm00212a002
Rattus norvegicus Rattus norvegicus Ki 10.5 nM 10.1021/jm00376a020
Rattus norvegicus Rattus norvegicus LMA 277.0 None 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus LMA 366.0 None 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus LMA 491.0 None 10.1021/jm00043a013
Rattus norvegicus Rattus norvegicus Locomotor activity 52.0 None 10.1021/jm00390a004
Rattus norvegicus Rattus norvegicus Locomotor activity 277.0 None 10.1021/jm00390a004
Rattus norvegicus Rattus norvegicus Locomotor activity 366.0 None 10.1021/jm00390a004
Rattus norvegicus Rattus norvegicus MED 100.0 ug kg-1 10.1021/jm00128a044
Rattus norvegicus Rattus norvegicus Motor activity 624.0 None 10.1021/jm00144a021
Rattus norvegicus Rattus norvegicus Motor activity 624.0 None 10.1021/jm00350a008
Rattus norvegicus Rattus norvegicus No. of counts 227.0 uM kg-1 10.1021/jm00393a025
Rattus norvegicus Rattus norvegicus No. of counts 366.0 uM kg-1 10.1021/jm00393a025
Rattus norvegicus Rattus norvegicus pD2 7.5 None 10.1021/jm00060a004
Rattus norvegicus Rattus norvegicus Potency ratio 1.0 None 10.1021/jm00160a036
Rattus norvegicus Rattus norvegicus Receptor state nan None 10.1021/jm00100a006
Rattus norvegicus Rattus norvegicus rel ko 1.0 None 10.1021/jm00136a012
Rattus norvegicus Rattus norvegicus Reversal 100.0 % 10.1016/S0960-894X(00)80249-8
Rattus norvegicus Rattus norvegicus Reversal 104.0 % 10.1021/jm00105a039
Rattus norvegicus Rattus norvegicus Rotational behavior 175.21 turns hr-1 10.1021/jm00181a010
Rattus norvegicus Rattus norvegicus Stereotypy score 18.0 None 10.1021/jm00358a011
Rattus norvegicus Rattus norvegicus Stimulation 91.5 % 10.1021/jm00164a022
Rattus norvegicus Rattus norvegicus Synaptic site nan None 10.1021/jm00100a006
Rattus norvegicus Rattus norvegicus TIME 0.0 hr 10.1021/jm00198a008
Rattus norvegicus Rattus norvegicus TIME 0.55 hr 10.1021/jm00198a008
Rattus norvegicus Rattus norvegicus TIME 0.55 hr 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus TIME 0.9167 hr 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus TIME 1.0 hr 10.1021/jm00198a008
Rattus norvegicus Rattus norvegicus TIME 1.05 hr 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus TIME 2.4 hr 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus TIME 2.55 hr 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus TIME 3.967 hr 10.1021/jm00223a006
Rattus norvegicus Rattus norvegicus Turns 1268.0 None 10.1021/jm00100a006
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Activity nan None 10.1016/j.bmc.2008.05.077
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 296.0 nM 10.1021/jm00004a011
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 296.0 nM 10.1021/jm960188q
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki 296.0 nM 10.1021/jm960189i
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None 10.1016/j.bmc.2008.05.077
Rattus norvegicus Serotonin (5-HT) receptor IC50 4500.0 nM 10.1021/jm00148a030
Rattus norvegicus Serotonin (5-HT) receptor IC50 4500.0 nM 10.1021/jm00381a017
Rattus norvegicus Serotonin (5-HT) receptor IC50 10000.0 nM 10.1021/jm00148a030
Rattus norvegicus Serotonin (5-HT) receptor IC50 10000.0 nM 10.1021/jm00381a017
Rattus norvegicus Serotonin 7 (5-HT7) receptor Ki 188.0 nM 10.1016/s0960-894x(00)00655-7
Rattus norvegicus Serotonin 7 (5-HT7) receptor Ki 188.0 nM 10.1021/jm0108505
Rattus norvegicus Serotonin 7 (5-HT7) receptor Ki 188.0 nM 10.1021/jm9911433
Rattus norvegicus Sigma opioid receptor IC50 1000.0 nM 10.1021/jm980212v
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 501.2 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 2993.5 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 9466.2 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 10000.0 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 44668.4 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Schistosoma mansoni Thioredoxin glutathione reductase Potency 3548.1 nM None
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Simian virus 40 Large T antigen IC50 20250.0 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 4256.2 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 11995.5 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 12589.3 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 16944.1 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 19011.5 nM None
None ADMET Binding 85.7 % 10.1021/jm50001a014
None ADMET Binding 86.2 % 10.1021/jm50001a014
None ADMET Binding 86.8 % 10.1021/jm50001a014
None ADMET Binding 87.0 % 10.1021/jm50001a014
None ADMET Binding 89.1 % 10.1021/jm50001a014
None ADMET Binding 90.4 % 10.1021/jm50001a014
None ADMET Binding 90.7 % 10.1021/jm50001a014
None ADMET Binding 91.3 % 10.1021/jm50001a014
None ADMET Binding 93.0 % 10.1021/jm50001a014
None ADMET Binding 93.5 % 10.1021/jm50001a014
None ADMET Binding 94.8 % 10.1021/jm50001a014
None ADMET Binding 94.9 % 10.1021/jm50001a014
None ADMET Binding 95.3 % 10.1021/jm50001a014
None ADMET Binding 96.6 % 10.1021/jm50001a014
None ADMET Binding 96.8 % 10.1021/jm50001a014
None ADMET Binding 96.9 % 10.1021/jm50001a014
None ADMET Binding 97.8 % 10.1021/jm50001a014
None ADMET Binding energy 11.9 kCal mol-1 10.1021/jm00378a021
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET CL 40.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET LC50 10000.0 nM 10.1016/j.bmc.2013.09.022
None ADMET MRT 0.67 hr 10.1124/dmd.108.020479
None ADMET Stability 36.68 % 10.1016/j.bmcl.2020.127053
None ADMET Stability 80.43 % 10.1016/j.bmcl.2020.127053
None ADMET Stability 89.33 % 10.1016/j.bmcl.2020.127053
None ADMET Stability 99.73 % 10.1016/j.bmcl.2020.127053
None ADMET Stability 100.0 % 10.1016/j.bmcl.2020.127053
None ADMET T1/2 0.68 hr 10.1124/dmd.108.020479
None ADMET T1/2 1.0 hr 10.1016/j.bmc.2018.01.028
None ADMET Vdss 1.6 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET EC50 168.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 310.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 350.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 683.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 5260.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 10190.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 14580.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET ED50 nan mg.kg-1 10.1021/jm00047a010
None NON-PROTEIN TARGET Fu 0.057 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 1.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC25 14.0 uM 10.1016/j.bmc.2006.11.037
None NON-PROTEIN TARGET IC25 16.2 uM 10.1016/j.bmc.2006.11.037
None NON-PROTEIN TARGET IC50 61659500.19 nM 10.1016/j.bmc.2006.11.037
None NON-PROTEIN TARGET pIC25 -1.15 None 10.1016/j.bmc.2006.11.037
None NON-PROTEIN TARGET Ratio 1.0 None 10.1021/jm00349a019
None No relevant target Drug metabolism 8.0 uM 10.1016/j.bmc.2018.01.028
None No relevant target Drug metabolism 23.0 uM 10.1016/j.bmc.2018.01.028
None No relevant target Drug metabolism 25.0 uM 10.1016/j.bmc.2018.01.028
None No relevant target Drug metabolism 32.0 uM 10.1016/j.bmc.2018.01.028
None No relevant target Drug metabolism 47.0 uM 10.1016/j.bmc.2018.01.028
None No relevant target Drug metabolism 50.0 uM 10.1016/j.bmc.2018.01.028
None No relevant target Drug metabolism 80.0 % 10.1016/j.bmcl.2017.03.082
None No relevant target Drug metabolism nan None 10.1016/j.bmc.2018.01.028
None No relevant target log K 0.33 None 10.1021/jm9003945
None No relevant target log K 2.74 None 10.1021/jm9003945
None No relevant target Log Kmemb 1.1 None 10.1021/jm0309001
None No relevant target LogP 2.49 None 10.1021/jm9003945
None No relevant target pKa 8.92 None 10.1016/j.ejmech.2009.06.004
None Radical scavenging activity IC25 nan None 10.1016/j.bmc.2006.11.037
None Unchecked Ac50 5.623 uM None
None Unchecked Ac50 25.12 uM None
None Unchecked Ac50 28.18 uM None
None Unchecked Ac50 31.62 uM None
None Unchecked Ac50 35.48 uM None
None Unchecked AC50 5623.4 nM None
None Unchecked AC50 25118.9 nM None
None Unchecked AC50 28183.8 nM None
None Unchecked AC50 31630.0 nM None
None Unchecked AC50 35481.3 nM None
None Unchecked Activity 100.0 uM kg-1 10.1021/jm00175a001
None Unchecked Activity nan None 10.1038/nchembio873
None Unchecked EC50 1.5 nM 10.1021/jm060662k
None Unchecked EC50 10000.0 nM 10.1016/j.bmc.2013.09.022
None Unchecked EC50 110000.0 nM None
None Unchecked Efficacy 84.0 % 10.1021/jm060662k
None Unchecked Hepatotoxicity (acute) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 15500.0 nM 10.1039/d1md00274k
None Unchecked IC50 30000.0 nM 10.1016/j.bmcl.2017.03.082
None Unchecked ID50 0.018 umol.kg-1 10.1021/jm060959i
None Unchecked Inhibition 40.0 % 10.1016/j.bmc.2007.12.040
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki 532.0 nM 10.1016/j.bmcl.2008.11.025
None Unchecked pD2 6.2 None 10.1021/jm00060a004
None Unchecked Potency 562.3 nM None
None Unchecked Potency 1000.0 nM None
None Unchecked Potency 3981.1 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 29081.0 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 32196.8 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency ratio 1.0 None 10.1021/jm00354a010
None Unchecked Ratio 2.3 None 10.1021/jm00113a010
None Unchecked Ratio 5.0 None 10.1021/jm00398a032
None Unchecked Ratio nan None 10.1016/j.bmc.2013.09.022
None Unchecked Ratio EC50 3.0 None 10.1016/j.bmcl.2007.10.059
None Unchecked Ratio EC50 6.5 None 10.1016/j.bmc.2013.05.014
None Unchecked Ratio EC50 29.1 None 10.1038/nchembio873
None Unchecked Ratio Ki 3.0 None 10.1016/j.bmc.2008.02.038
None Unchecked Ratio Ki 3.2 None 10.1016/j.bmc.2013.05.014
None Unchecked Ratio Ki 4.8 None 10.1016/j.ejmech.2012.07.025
None Unchecked Ratio Ki 6.3 None 10.1016/j.bmc.2009.04.047
None Unchecked Ratio Ki 6.3 None 10.1016/j.ejmech.2011.04.028
None Unchecked Ratio Ki 9.3 None 10.1016/j.bmc.2013.05.014
None Unchecked Ratio Ki 13.0 None 10.1016/j.ejmech.2012.07.025
None Unchecked Ratio Ki 65.0 None 10.1016/j.ejmech.2012.07.025
None Unchecked Ratio Ki 532.0 None 10.1021/jm701045j
None Unchecked Selectivity ratio 0.28 None 10.1021/jm00403a022
None Unchecked Selectivity ratio 4.5 None 10.1021/jm00403a022

Metabolism Information