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Dorsomorphin

AlkaPlorer ID: AK007897

Synonym: None

IUPAC Name: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Structure

SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

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InChI: InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

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InChIKey: XHBVYDAKJHETMP-UHFFFAOYSA-N

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Properties Information

Molecule Weight: 399.4980000000001

TPSA？: 55.550000000000004

MolLogP？: 4.323000000000003

Number of H-Donors: 0

Number of H-Acceptors: 6

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Danio rerio Danio rerio Activity 80.0 % 10.1021/acs.jnatprod.1c00002
Danio rerio Danio rerio Activity nan None 10.1038/nchembio.2007.54
Danio rerio Danio rerio FC 3.0 None 10.1038/nchembio.2007.54
Danio rerio Danio rerio Inhibition nan % 10.1038/nchembio.2007.54
Danio rerio Vascular endothelial growth factor receptor 2 Inhibition nan % 10.1038/nchembio.2007.54
Gallus gallus Tyrosine-protein kinase SRC Activity 25.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 94.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens A2780 EC50 900.0 nM 10.1016/j.bmcl.2019.126813
Homo sapiens Activin receptor type-1 IC50 67.5 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Activin receptor type-1 IC50 68.0 nM 10.1021/acsmedchemlett.3c00127
Homo sapiens Activin receptor type-1 IC50 148.1 nM None
Homo sapiens Activin receptor type-1B IC50 25740.0 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Activin receptor type-1B Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK IC50 41.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens AMP-activated protein kinase, AMPK IC50 230.0 nM 10.1021/acs.jmedchem.5b00446
Homo sapiens AMP-activated protein kinase, AMPK Inhibition nan % 10.1021/acs.jmedchem.0c01132
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, beta-1 subunit IC50 234.6 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens AMP-activated protein kinase, beta-1 subunit IC50 318.2 nM None
Homo sapiens Bone morphogenetic protein 4 IC50 430.0 nM 10.1016/j.bmcl.2008.06.052
Homo sapiens Bone morphogenetic protein receptor type-1A IC50 95.0 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Bone morphogenetic protein receptor type-1A IC50 95.0 nM 10.1021/acsmedchemlett.3c00127
Homo sapiens Bone morphogenetic protein receptor type-1B IC50 235.0 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Bone morphogenetic protein receptor type-1B IC50 235.0 nM 10.1021/acsmedchemlett.3c00127
Homo sapiens Bone morphogenetic protein receptor type-1B IC50 467.0 nM 10.1021/jm500115w
Homo sapiens Bone morphogenetic protein receptor type-2 IC50 74.0 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Bone morphogenetic protein receptor type-2 IC50 74.0 nM 10.1021/acsmedchemlett.3c00127
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Activity 46.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Activity 85.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens CaM-kinase kinase alpha Activity 47.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 65.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 85.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Activity 43.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Activity 66.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Activity 97.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Activity 82.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 88.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 12.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 24.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 9.0 % 10.1042/bj20070797
Homo sapiens Ephrin type-A receptor 1 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 IC50 11.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Ephrin type-A receptor 2 Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Activity 81.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Hep 3B2 Inhibition 27.0 % 10.1038/nchembio.2007.54
Homo sapiens Hepatocyte growth factor receptor Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens HepG2 FC 50.0 None 10.1038/nchembio.2007.54
Homo sapiens Histone deacetylase 6 Inhibition 60.66 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 69.73 % 10.6019/CHEMBL4808148
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 26.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 63.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 98.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Activity 51.0 % 10.1042/bj20070797
Homo sapiens Insulin-like growth factor I receptor Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 143.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase IC50 16000.0 nM 10.1016/j.bmcl.2011.04.149
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Activity 80.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Activity 102.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Activity 96.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Activity 110.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Activity 87.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 19.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 IC50 11.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens MAP kinase p38 alpha Activity 93.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Activity 89.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Activity 88.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Activity 82.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 64.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Activity 5.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens MCF7 EC50 4900.0 nM 10.1016/j.bmcl.2019.126813
Homo sapiens Misshapen-like kinase 1 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 15 Activity 9.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Activity 52.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Activity 92.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Activity 94.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Activity 94.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Activity 37.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 129.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Activity 67.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Activity 59.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 62.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 IC50 210.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 66.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 64.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Activity 72.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 65.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 40.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 57.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 54.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 114.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 74.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 79.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 58.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 109.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 127.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 106.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase receptor R3 IC50 106.3 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Activity 45.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I IC50 10000.0 nM 10.1021/acs.jmedchem.5b00446
Homo sapiens TGF-beta receptor type I IC50 10760.0 nM None
Homo sapiens TGF-beta receptor type I IC50 17090.0 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens TGF-beta receptor type I Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type II IC50 102.9 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Thyroid hormone receptor beta-1 Potency 707945.8 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity -4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Activity 69.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK IC50 16.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 IC50 1.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC IC50 2.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES IC50 29.8 nM 10.1016/j.bmcl.2013.05.072
Homo sapiens Tyrosine-protein kinase YES IC50 195.9 nM 10.1016/j.bmcl.2013.05.072
Homo sapiens Tyrosine-protein kinase YES Potency 54.7 nM None
Homo sapiens Tyrosine-protein kinase YES Potency 195.9 nM None
Homo sapiens Tyrosine-protein kinase YES Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 11.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 4.0 nM 10.1016/j.bmcl.2010.09.088
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 21.8 nM 10.1016/j.bmcl.2013.03.113
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 25.14 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 220.0 nM 10.1021/acs.jmedchem.5b00446
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 1.0 % 10.1042/bj20121418
Mus musculus C2C12 Activity nan None 10.1038/nchembio.2007.54
Mus musculus Mus musculus Activity 9.26 None 10.1016/j.bmc.2021.116522
Mus musculus Mus musculus Activity 15.63 None 10.1016/j.bmc.2021.116522
Mus musculus Mus musculus Activity 42.56 % 10.1016/j.bmc.2021.116522
Mus musculus Mus musculus Activity 53.64 None 10.1016/j.bmc.2021.116522
Mus musculus Mus musculus Activity 55.42 None 10.1016/j.bmc.2021.116522
Mus musculus Mus musculus Activity 60.0 % 10.1038/nchembio.2007.54
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2021.116522
Mus musculus Mus musculus Inhibition nan % 10.1038/nchembio.2007.54
Mus musculus TGF-beta receptor type-1 Inhibition nan % 10.1038/nchembio.2007.54
Mus musculus Tyrosine-protein kinase LCK Activity 20.0 % 10.1042/bj20070797
Rattus norvegicus AMP-activated protein kinase, AMPK IC50 1280.0 nM 10.1016/j.ejmech.2022.114846
Rattus norvegicus Aorta EC50 nan None 10.1021/acs.jmedchem.0c01132
Rattus norvegicus Aorta Emax nan None 10.1021/acs.jmedchem.0c01132
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 22.97 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.73 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 2.77 % 10.21203/rs.3.rs-23951/v1
None ADMET CL 133.0 mL.min-1.g-1 10.1016/j.bmcl.2008.06.052
None ADMET T1/2 0.1733 hr 10.1016/j.bmcl.2008.06.052
None NON-PROTEIN TARGET Potency 37221.2 nM None
None Unchecked Activity 0.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 3.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 5.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 6.0 % 10.1042/bj20070797
None Unchecked Activity 10.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 15.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 17.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 19.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 22.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 27.0 % 10.1042/bj20070797
None Unchecked Activity 35.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 39.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 42.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 44.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 58.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 65.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 78.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 81.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 85.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 90.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 95.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 98.0 % 10.1038/nchembio.2007.54
None Unchecked Activity 100.0 % 10.1038/nchembio.2007.54
None Unchecked Activity nan None 10.1021/acs.jmedchem.0c01132
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c01800
None Unchecked Activity nan None 10.1021/acs.jnatprod.1c00002
None Unchecked Activity nan None 10.1038/nchembio.2007.54
None Unchecked EC100 2.5 uM 10.1021/acs.jmedchem.5b00446
None Unchecked FC 13.17 None 10.1016/j.bmc.2021.116522
None Unchecked FC 26.36 None 10.1016/j.bmc.2021.116522
None Unchecked FC 45.32 None 10.1016/j.bmc.2021.116522
None Unchecked FC 52.08 None 10.1016/j.bmc.2021.116522
None Unchecked IC50 109.0 nM 10.1021/acs.jmedchem.1c00302
None Unchecked IC50 470.0 nM 10.1038/nchembio.2007.54
None Unchecked IC50 2380.0 nM 10.1016/j.ejmech.2020.112316
None Unchecked IC50 15890.0 nM 10.1016/j.ejmech.2020.112316
None Unchecked IC50 82200.0 nM 10.1021/acs.jmedchem.0c01132
None Unchecked IC50 100000.0 nM 10.1021/acs.jmedchem.0c01132
None Unchecked Inhibition nan % 10.1016/j.bmcl.2010.09.088
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.0c01132
None Unchecked Inhibition nan % 10.1038/nchembio.2007.54
None Unchecked Ki 109.0 nM 10.1021/jm401994c
None Unchecked Ki 10000.0 nM 10.1038/nchembio.2007.54
None Unchecked Potency 2635.1 nM None
None Unchecked Potency 9431.3 nM None
None Unchecked Potency 11770.4 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 16626.1 nM None
None Unchecked Potency 18654.8 nM None
None Unchecked Potency 23485.0 nM None
None Unchecked Potency 37221.2 nM None

Metabolism Information