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Paclitaxel

AlkaPlorer ID: AK008067

Synonym: None

IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Structure

SMILES: CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O

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InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

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InChIKey: RCINICONZNJXQF-MZXODVADSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Chlorophytum borivilianum Chlorophytum Asparagaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Penicillium concentricum Penicillium Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Ligularia rumicifolia Ligularia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Kleinhovia hospita Kleinhovia Malvaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Cryptocarya laevigata Cryptocarya Lauraceae Laurales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aspergillus flavus Aspergillus Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Spatholobus suberectus Spatholobus Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aspergillus ochraceopetaliformis Aspergillus Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Koeberlinia spinosa Koeberlinia Koeberliniaceae Brassicales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dendrobium findlayanum Dendrobium Orchidaceae Asparagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Eriolarynx iochromoides Eriolarynx Solanaceae Solanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Stachybotrys chartarum Stachybotrys Stachybotryaceae Hypocreales Sordariomycetes Ascomycota Fungi Eukaryota
Rinorea virgata Rinorea Violaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Brucea javanica Brucea Simaroubaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Penicillium aurantiacobrunneum Penicillium Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Cryptocarya rigidifolia Cryptocarya Lauraceae Laurales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Taxus cuspidata Taxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Garcinia oblongifolia Garcinia Clusiaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Streptocaulon juventas Streptocaulon Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Torreya grandis Torreya Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Isodon scoparius Isodon Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aspergillus versicolor Aspergillus Aspergillaceae Eurotiales Eurotiomycetes Ascomycota Fungi Eukaryota
Elaphoglossum paleaceum Elaphoglossum Dryopteridaceae Polypodiales Polypodiopsida Streptophyta Viridiplantae Eukaryota
Trichospira verticillata Trichospira Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Kadsura coccinea Kadsura Schisandraceae Austrobaileyales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Daphne giraldii Daphne Thymelaeaceae Malvales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Leucetta chagosensis Leucetta Leucettidae Clathrinida Calcarea Porifera Metazoa Eukaryota
Isodon pharicus Isodon Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Euphorbia soongarica Euphorbia Euphorbiaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Kopsia officinalis Kopsia Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hypericum chinense Hypericum Hypericaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Artemisia minor Artemisia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Culcita novaeguineae Culcita Oreasteridae Valvatida Asteroidea Echinodermata Metazoa Eukaryota
Persicaria dissitiflora Persicaria Polygonaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Paraconiothyrium Didymosphaeriaceae Pleosporales Dothideomycetes Ascomycota Fungi Eukaryota
Taxus wallichiana Taxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Trichoderma velutinum Trichoderma Hypocreaceae Hypocreales Sordariomycetes Ascomycota Fungi Eukaryota
Mangifera indica Mangifera Anacardiaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ancistrocladus ileboensis Ancistrocladus Ancistrocladaceae Caryophyllales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Alangium longiflorum Alangium Cornaceae Cornales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Albizia coriaria Albizia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Sinularia flexibilis Sinularia Sinulariidae Malacalcyonacea Anthozoa Cnidaria Metazoa Eukaryota
Acronychia trifoliolata Acronychia Rutaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Salvia cavaleriei Salvia Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Homo sapiens Homo Hominidae Primates Mammalia Chordata Metazoa Eukaryota
Casearia membranacea Casearia Salicaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Chaetomium elatum Chaetomium Chaetomiaceae Sordariales Sordariomycetes Ascomycota Fungi Eukaryota
Isodon tenuifolius Isodon Lamiaceae Lamiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Muraltia spinosa Muraltia Polygalaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Taxus mairei Taxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Rinorea bengalensis Rinorea Violaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Taxus baccata Taxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Curcuma longa Curcuma Zingiberaceae Zingiberales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Austrobaileya scandens Austrobaileya Austrobaileyaceae Austrobaileyales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Amentotaxus argotaenia Amentotaxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Carthamus tinctorius Carthamus Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Aniba citrifolia Aniba Lauraceae Laurales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Burkholderia sp. Burkholderia Burkholderiaceae Burkholderiales Betaproteobacteria Pseudomonadota None Bacteria
Petradoria pumila Petradoria Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Mycale hentscheli Mycale Mycalidae Poecilosclerida Demospongiae Porifera Metazoa Eukaryota
Tabernaemontana corymbosa Tabernaemontana Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Taxus canadensis Taxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Cacospongia mycofijiensis Cacospongia Thorectidae Dictyoceratida Demospongiae Porifera Metazoa Eukaryota
Corylus avellana Corylus Betulaceae Fagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ptilonia australasica Ptilonia Bonnemaisoniaceae Bonnemaisoniales Florideophyceae Rhodophyta None Eukaryota
Cedrus deodara Cedrus Pinaceae Pinales Pinopsida Streptophyta Viridiplantae Eukaryota
Juglans regia Juglans Juglandaceae Fagales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Hypericum faberi Hypericum Hypericaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Punica granatum Punica Lythraceae Myrtales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Picralima nitida Picralima Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Ophioparma ventosa Ophioparma Ophioparmaceae Umbilicariales Lecanoromycetes Ascomycota Fungi Eukaryota
Taxus brevifolia Taxus Taxaceae Cupressales Pinopsida Streptophyta Viridiplantae Eukaryota
Calotropis gigantea Calotropis Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Selaginella moellendorffii Selaginella Selaginellaceae Selaginellales Lycopodiopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 853.918

TPSA？: 221.29

MolLogP？: 3.735700000000004

Number of H-Donors: 4

Number of H-Acceptors: 14

RingCount: 7

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Artemia Artemia LC50 0.28 ug.mL-1 10.1021/np50075a028
Bacillus anthracis Anthrax lethal factor Potency 12589.3 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 10000.0 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 14125.4 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 28183.8 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 29620.3 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 44668.4 nM None
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 50118.7 nM None
Bacillus subtilis Bacillus subtilis Activity nan None 10.1126/science.1159961
Bos taurus Monoamine oxidase A Activity nan None 10.1021/jm800656v
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Bos taurus Tubulin Activity 4.2 uM 10.1016/j.bmc.2014.05.048
Bos taurus Tubulin Activity nan None 10.1016/j.bmc.2015.08.038
Bos taurus Tubulin Activity nan None 10.1016/j.bmc.2015.12.016
Bos taurus Tubulin Activity nan None 10.1016/j.ejmech.2019.111583
Bos taurus Tubulin Activity nan None 10.1021/acs.jmedchem.9b00551
Bos taurus Tubulin Activity nan None 10.1021/jm500034j
Bos taurus Tubulin EC50 830.0 nM 10.1021/jm0001119
Bos taurus Tubulin ED50 0.7 uM 10.1021/jm00100a031
Bos taurus Tubulin Inhibition 20.0 % 10.1039/C2MD20085F
Bos taurus Tubulin Inhibition nan % 10.1016/j.bmc.2015.03.085
Bos taurus Tubulin OD 0.52 None 10.1016/j.ejmech.2019.111583
Bos taurus Tubulin Ratio 1.0 None 10.1016/0960-894X(94)00468-U
Bos taurus Tubulin Ratio 1.0 None 10.1016/0960-894X(95)00020-T
Bos taurus Tubulin beta chain GTPase Activity 1.4 None 10.1021/jm010940+
Bos taurus Tubulin beta chain GTPase Activity 3.3 None 10.1021/jm010940+
Botrytis cinerea Botrytis cinerea Activity 0.0 % 10.1016/j.bmc.2015.08.038
Canis lupus familiaris MDCK Papp 0.09 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 0.13 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 0.2 10^-6 cm/s 10.1016/j.bmcl.2007.04.058
Canis lupus familiaris MDCK Papp 0.46 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 2.02 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 3.24 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 24.36 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 28.5 10^-6 cm/s 10.1016/j.bmcl.2007.04.058
Canis lupus familiaris MDCK Papp 29.81 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Papp 44.09 ucm/s 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Ratio 7.06 None 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Ratio 12.08 None 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Ratio 143.0 None 10.1016/j.bmcl.2007.04.058
Canis lupus familiaris MDCK Ratio 333.79 None 10.1016/j.bmc.2013.11.037
Canis lupus familiaris MDCK Ratio 344.23 None 10.1016/j.bmc.2013.11.037
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus sabaeus Vero ED50 0.3 ug ml-1 10.1021/np960079e
Chlorocebus sabaeus Vero GI50 30.0 nM 10.1016/j.ejmech.2014.03.086
Chlorocebus sabaeus Vero IC50 100.0 ug.mL-1 10.1016/j.ejmech.2016.04.019
Chlorocebus sabaeus Vero IC50 650.0 nM 10.1016/j.ejmech.2015.11.009
Chlorocebus sabaeus Vero IC50 nan None 10.1039/C4MD00573B
Chlorocebus sabaeus Vero TC50 0.53 uM 10.1016/j.bmc.2009.10.019
Chlorocebus sabaeus Vero TC50 0.53 uM 10.1021/acs.jmedchem.5b01380
Chlorocebus sabaeus Vero TGI nan None 10.1016/j.ejmech.2014.03.086
Clostridium botulinum Botulinum neurotoxin type A Activity 7.0 % 10.1021/jm301829h
Clostridium botulinum Botulinum neurotoxin type A Activity nan None 10.1021/jm301829h
Clostridium botulinum Botulinum neurotoxin type A IC50 5200.0 nM 10.1021/jm301829h
Clostridium botulinum Botulinum neurotoxin type A Inhibition 85.0 % 10.1021/jm301829h
Cricetulus griseus CHO ED50 0.35 uM 10.1021/jm00107a042
Cricetulus griseus CHO IC50 170.0 nM 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO IC50 170.0 nM 10.1021/jm200488a
Cricetulus griseus CHO-K1 GI50 5900.0 nM 10.1021/np200041v
Cricetulus griseus CHO-K1 Selectivity Index 380.0 None 10.1021/jm8006257
Cricetulus griseus CHO-M19 IC50 0.003 ug.mL-1 10.1016/j.bmc.2007.03.041
Cricetulus griseus CHO-TAX 5-6 IC50 520.0 nM 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-TAX 5-6 IC50 520.0 nM 10.1021/jm200488a
Cricetulus griseus CHO-TAX 5-6 Ratio IC50 3.1 None 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-TAX 5-6 Ratio IC50 3.1 None 10.1021/jm200488a
Cricetulus griseus CHO-VV 3-2 IC50 140.0 nM 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-VV 3-2 IC50 140.0 nM 10.1021/jm200488a
Cricetulus griseus CHO-VV 3-2 Ratio IC50 0.82 None 10.1016/j.ejmech.2011.08.034
Cricetulus griseus CHO-VV 3-2 Ratio IC50 0.82 None 10.1021/jm200488a
Drosophila melanogaster Drosophila melanogaster GI nan None 10.1016/j.bmc.2011.09.059
Electrophorus electricus Acetylcholinesterase Inhibition 12.49 % 10.1016/j.bmc.2012.09.040
Equus caballus Cholinesterase Inhibition -2.88 % 10.1016/j.bmc.2012.09.040
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmcl.2016.11.025
Escherichia coli GroEL/GroES IC50 56000.0 nM 10.1016/j.bmcl.2019.02.028
Escherichia coli GroEL/GroES IC50 114000.0 nM 10.1016/j.bmcl.2019.02.028
Escherichia coli GroEL/GroES Inhibition 93.0 % 10.1016/j.bmcl.2019.02.028
Escherichia coli GroEL/GroES Inhibition 96.0 % 10.1016/j.bmcl.2019.02.028
Escherichia coli K-12 Beta-lactamase AmpC Potency 12589.3 nM None
Escherichia coli (strain K12) 60 kDa chaperonin IC50 250000.0 nM 10.1016/j.bmcl.2019.02.028
Gallus gallus Tubulin beta-4 chain Inhibition 98.0 % 10.1021/acs.jnatprod.7b01047
Hepatitis C virus NS3 IC50 1000.0 nM 10.1021/jm0400101
Homo sapiens 143B IC50 5560.0 nM 10.1016/j.bmc.2017.09.019
Homo sapiens 1A9 Activity 6.6 % 10.1021/jm901249g
Homo sapiens 1A9 Activity 13.7 % 10.1021/jm901249g
Homo sapiens 1A9 Activity 43.3 % 10.1021/jm901249g
Homo sapiens 1A9 Activity 52.2 % 10.1021/jm901249g
Homo sapiens 1A9 Activity 76.5 % 10.1021/jm901249g
Homo sapiens 1A9 Activity 81.9 % 10.1021/jm901249g
Homo sapiens 1A9 ED50 0.001 ug ml-1 10.1016/j.bmcl.2007.06.083
Homo sapiens 1A9 ED50 0.002 ug ml-1 10.1021/jm020548b
Homo sapiens 1A9 ED50 0.002 ug ml-1 10.1021/np030241v
Homo sapiens 1A9 ED50 0.041 ug ml-1 10.1021/np030241v
Homo sapiens 1A9 ED50 1.0 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens 1A9 ED50 2.09 nM 10.1016/j.bmc.2011.01.001
Homo sapiens 1A9 GI50 0.71 nM 10.1021/jm061385k
Homo sapiens 1A9 IC50 2.0 nM 10.1021/np0500575
Homo sapiens 1A9 IC50 3.71 nM 10.1021/acs.jmedchem.7b00315
Homo sapiens 1A9 IC50 3.9 nM 10.1016/j.bmc.2014.05.048
Homo sapiens 1A9 IC50 4.8 nM 10.1021/jm061071x
Homo sapiens 1A9 IC50 21.5 nM 10.1021/jm061071x
Homo sapiens 1A9 Ratio IC50 1.1 None 10.1016/j.bmc.2014.05.048
Homo sapiens 1A9 Ratio IC50 4.5 None 10.1021/jm061071x
Homo sapiens 1A9 Ratio IC50 8.4 None 10.1016/j.bmc.2014.05.048
Homo sapiens 1A9 Ratio IC50 20.8 None 10.1016/j.bmc.2014.05.048
Homo sapiens 1A9/ptx-10 ED50 0.041 ug ml-1 10.1021/jm020548b
Homo sapiens 1A9/ptx-10 ED50 nan None 10.1021/np030241v
Homo sapiens 1A9/ptx-10 GI50 64.0 nM 10.1021/jm061385k
Homo sapiens 1A9/ptx-10 IC50 157.0 nM 10.1021/jm061071x
Homo sapiens 1A9/ptx-10 Ratio IC50 20.0 None 10.1021/jm061071x
Homo sapiens 1A9/ptx-22 GI50 51.0 nM 10.1021/jm061385k
Homo sapiens 2008 GI50 0.0092 nM 10.1021/jm0204136
Homo sapiens 2008 GI50 3.0 nM 10.1021/jm400575x
Homo sapiens 2008 RatioGI50 600.0 None 10.1021/jm400575x
Homo sapiens 697 IC50 1.495 nM 10.6019/CHEMBL1201861
Homo sapiens 769-P IC50 7100.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens 769-P IC50 7100.0 nM 10.1016/j.ejmech.2009.12.060
Homo sapiens 769-P IC50 7100.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens 769-P IC50 7100.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens 786-0 GI50 19.95 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens 786-0 GI50 20.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens 786-0 GI50 33.73 nM None
Homo sapiens 786-0 GI50 39.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens 786-0 GI50 39.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens 786-0 IC50 2.55 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens 786-0 IC50 4.0 nM 10.1021/jm200454y
Homo sapiens 786-0 IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens 786-0 IC50 31.0 nM 10.1021/jm200454y
Homo sapiens 786-0 IC50 80.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens 786-0 IC50 80.0 nM 10.1016/j.ejmech.2009.12.060
Homo sapiens 786-0 IC50 80.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens 786-0 IC50 80.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens 786-0 Log IC50 -7.3 nM 10.1021/jm049405a
Homo sapiens 786-0 TGI 800.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens 8-MG-BA IC50 7.958 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 9.598 nM 10.6019/CHEMBL1201861
Homo sapiens A121 IC50 6.1 nM 10.1016/S0960-894X(01)80298-5
Homo sapiens A121 IC50 6.1 nM 10.1016/S0960-894X(01)80568-0
Homo sapiens A121 IC50 6.1 nM 10.1021/jm00036a004
Homo sapiens A121 IC50 6.1 nM 10.1021/jm960563e
Homo sapiens A121 IC50 6.1 nM 10.1021/jm9606711
Homo sapiens A121 IC50 6.3 nM 10.1016/S0960-894X(96)00595-1
Homo sapiens A121 IC50 6.3 nM 10.1021/jm9604080
Homo sapiens A121 Inhibition 6.1 % 10.1016/s0960-894x(99)00161-4
Homo sapiens A 172 GI50 10.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens A204 Log IC50 -8.5 nM 10.1021/jm049405a
Homo sapiens A2058 IC50 4.7 nM 10.1016/j.bmc.2013.03.078
Homo sapiens A2058 IC50 nan None 10.1021/np200697j
Homo sapiens A253 cell line IC50 17.38 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 Activity 6.5 % 10.1038/nchembio853
Homo sapiens A2780 Activity 7.0 % 10.1038/nchembio853
Homo sapiens A2780 Activity 10.42 % 10.1016/j.bmcl.2017.07.063
Homo sapiens A2780 Activity 13.37 % 10.1016/j.bmcl.2017.07.063
Homo sapiens A2780 Activity 15.7 % 10.1038/nchembio853
Homo sapiens A2780 Activity 22.6 % 10.1016/j.bmc.2019.115044
Homo sapiens A2780 Activity 70.7 % 10.1016/j.bmcl.2017.07.063
Homo sapiens A2780 Activity 70.8 % 10.1038/nchembio853
Homo sapiens A2780 Activity nan None 10.1016/j.ejmech.2021.113256
Homo sapiens A2780 Concentration 0.46 uM 10.1016/j.bmcl.2005.03.018
Homo sapiens A2780 EC50 2.4 nM 10.1016/j.bmcl.2019.04.035
Homo sapiens A2780 EC50 2.5 nM 10.1016/j.bmcl.2019.04.035
Homo sapiens A2780 EC50 10000.0 nM 10.1021/jm800386y
Homo sapiens A2780 GI 96.68 % 10.1016/j.bmc.2013.11.037
Homo sapiens A2780 GI50 0.27 nM 10.1016/j.bmcl.2011.09.069
Homo sapiens A2780 IC50 0.00013 ug.mL-1 10.1016/j.bmcl.2008.12.091
Homo sapiens A2780 IC50 0.000587 ug.mL-1 10.1016/j.bmcl.2016.02.055
Homo sapiens A2780 IC50 0.00676 ug.mL-1 10.1016/j.bmcl.2004.10.097
Homo sapiens A2780 IC50 0.136 ug.mL-1 10.1021/np010552a
Homo sapiens A2780 IC50 0.4 nM 10.1016/j.bmc.2014.05.048
Homo sapiens A2780 IC50 0.62 nM 10.1016/j.bmcl.2011.06.034
Homo sapiens A2780 IC50 0.7 nM 10.1016/j.bmcl.2006.09.068
Homo sapiens A2780 IC50 0.82 nM 10.1016/j.ejmech.2011.02.011
Homo sapiens A2780 IC50 1.0 nM 10.1016/j.bmcl.2010.07.085
Homo sapiens A2780 IC50 1.0 nM 10.1016/j.bmcl.2011.04.030
Homo sapiens A2780 IC50 1.0 nM 10.1016/j.ejmech.2017.12.004
Homo sapiens A2780 IC50 1.0 nM 10.1021/np3000443
Homo sapiens A2780 IC50 1.0 nM 10.1021/np3008864
Homo sapiens A2780 IC50 1.0 nM 10.1038/nchembio853
Homo sapiens A2780 IC50 1.07 nM 10.1016/j.ejmech.2017.06.001
Homo sapiens A2780 IC50 1.3 nM 10.1016/j.bmcl.2008.12.018
Homo sapiens A2780 IC50 1.38 nM 10.1016/j.bmc.2014.02.036
Homo sapiens A2780 IC50 1.38 nM 10.1021/jm800086e
Homo sapiens A2780 IC50 1.38 nM 10.1021/np8006556
Homo sapiens A2780 IC50 1.5 nM 10.1021/acs.jmedchem.8b01742
Homo sapiens A2780 IC50 1.6 nM 10.1016/j.bmcl.2007.03.026
Homo sapiens A2780 IC50 1.7 nM 10.1016/j.bmcl.2009.04.070
Homo sapiens A2780 IC50 1.7 nM 10.1021/np8006556
Homo sapiens A2780 IC50 2.0 nM 10.1016/j.ejmech.2020.112323
Homo sapiens A2780 IC50 2.0 nM 10.1016/j.ejmech.2022.114112
Homo sapiens A2780 IC50 2.2 nM 10.1016/j.bmcl.2009.04.070
Homo sapiens A2780 IC50 2.2 nM 10.1021/np8006556
Homo sapiens A2780 IC50 2.7 nM 10.1021/jm9604080
Homo sapiens A2780 IC50 2.8 nM 10.1016/j.bmcl.2007.04.030
Homo sapiens A2780 IC50 2.8 nM 10.1016/j.bmcl.2018.11.023
Homo sapiens A2780 IC50 2.8 nM 10.1021/jm901249g
Homo sapiens A2780 IC50 3.3 nM 10.1016/j.ejmech.2018.11.004
Homo sapiens A2780 IC50 3.4 nM 10.1021/jm9604080
Homo sapiens A2780 IC50 3.4 nM 10.1021/jm9703350
Homo sapiens A2780 IC50 4.1 nM 10.1021/jm9604080
Homo sapiens A2780 IC50 4.6 nM 10.1021/jm034146v
Homo sapiens A2780 IC50 5.0 nM 10.1021/acs.jmedchem.6b00021
Homo sapiens A2780 IC50 5.3 nM 10.1021/jm034146v
Homo sapiens A2780 IC50 6.0 nM 10.1016/j.bmcl.2015.01.056
Homo sapiens A2780 IC50 6.3 nM 10.1021/np0701531
Homo sapiens A2780 IC50 7.2 nM 10.1016/j.bmcl.2009.04.070
Homo sapiens A2780 IC50 7.2 nM 10.1021/np8006556
Homo sapiens A2780 IC50 7.9 nM 10.1021/np900302w
Homo sapiens A2780 IC50 9.0 nM 10.1016/j.bmcl.2018.02.051
Homo sapiens A2780 IC50 10.0 nM 10.1021/jm100659v
Homo sapiens A2780 IC50 12.0 nM 10.1016/j.bmc.2013.03.078
Homo sapiens A2780 IC50 13.0 nM 10.1021/acs.jnatprod.7b00579
Homo sapiens A2780 IC50 13.0 nM 10.1021/acs.jnatprod.8b00135
Homo sapiens A2780 IC50 13.0 nM 10.1021/acs.jnatprod.8b00379
Homo sapiens A2780 IC50 13.0 nM 10.1021/acs.jnatprod.9b00724
Homo sapiens A2780 IC50 13.0 nM 10.1021/acs.jnatprod.9b01064
Homo sapiens A2780 IC50 13.4 nM 10.1021/acs.jnatprod.7b00857
Homo sapiens A2780 IC50 13.7 nM 10.1016/j.bmc.2017.06.017
Homo sapiens A2780 IC50 14.0 nM 10.1016/j.bmc.2009.02.022
Homo sapiens A2780 IC50 14.0 nM 10.1016/j.bmc.2011.06.082
Homo sapiens A2780 IC50 14.9 nM 10.1016/j.bmcl.2009.03.063
Homo sapiens A2780 IC50 15.0 nM 10.1016/j.bmc.2011.10.010
Homo sapiens A2780 IC50 15.0 nM 10.1021/jm061071x
Homo sapiens A2780 IC50 15.0 nM 10.1021/jm500024v
Homo sapiens A2780 IC50 15.2 nM 10.1016/j.ejmech.2020.113050
Homo sapiens A2780 IC50 17.0 nM 10.1021/np200499d
Homo sapiens A2780 IC50 18.0 nM 10.1021/acs.jnatprod.9b00340
Homo sapiens A2780 IC50 19.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens A2780 IC50 20.0 nM 10.1016/j.bmc.2010.07.069
Homo sapiens A2780 IC50 20.0 nM 10.1021/acs.jmedchem.1c01775
Homo sapiens A2780 IC50 20.0 nM 10.1021/np200697j
Homo sapiens A2780 IC50 20.4 nM 10.1021/acs.jnatprod.6b00887
Homo sapiens A2780 IC50 21.0 nM 10.1016/j.ejmech.2021.113897
Homo sapiens A2780 IC50 23.4 nM 10.1016/j.bmc.2008.10.090
Homo sapiens A2780 IC50 23.4 nM 10.1021/np070487q
Homo sapiens A2780 IC50 24.0 nM 10.1016/j.bmc.2013.10.038
Homo sapiens A2780 IC50 25.0 nM 10.1016/j.bmc.2007.03.041
Homo sapiens A2780 IC50 25.0 nM 10.1021/np030296x
Homo sapiens A2780 IC50 28.0 nM 10.1016/j.bmc.2012.10.012
Homo sapiens A2780 IC50 28.0 nM 10.1021/acs.jnatprod.5b00187
Homo sapiens A2780 IC50 28.0 nM 10.1021/acs.jnatprod.7b00247
Homo sapiens A2780 IC50 28.0 nM 10.1021/np300900a
Homo sapiens A2780 IC50 30.0 nM 10.1016/j.bmcl.2017.06.019
Homo sapiens A2780 IC50 50.0 nM 10.1016/j.bmcl.2018.02.051
Homo sapiens A2780 IC50 164.2 nM 10.1021/acs.jnatprod.7b00347
Homo sapiens A2780 IC50 270.0 nM 10.1021/acs.jmedchem.1c01775
Homo sapiens A2780 IC50 386.0 nM 10.1021/np8006556
Homo sapiens A2780 IC50 410.0 nM 10.1016/j.ejmech.2019.06.086
Homo sapiens A2780 IC50 547.0 nM 10.1021/jm9604080
Homo sapiens A2780 IC50 590.0 nM 10.1021/np400851k
Homo sapiens A2780 IC50 650.0 nM 10.1021/np1001863
Homo sapiens A2780 IC50 900.0 nM 10.1021/np900089v
Homo sapiens A2780 IC50 980.0 nM 10.1016/j.bmcl.2008.12.018
Homo sapiens A2780 IC50 1100.0 nM 10.1016/j.bmcl.2012.09.104
Homo sapiens A2780 IC50 1239.0 nM 10.1016/j.bmcl.2009.04.070
Homo sapiens A2780 IC50 2688.0 nM 10.1021/jm034146v
Homo sapiens A2780 IC50 2850.0 nM 10.1016/j.ejmech.2019.03.031
Homo sapiens A2780 IC50 2900.0 nM 10.1021/jm500024v
Homo sapiens A2780 IC50 4498.0 nM 10.1021/jm034146v
Homo sapiens A2780 IC50 5898.0 nM 10.1016/j.bmcl.2009.04.070
Homo sapiens A2780 IC50 8250.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens A2780 Ratio 116.0 None 10.1021/np8006556
Homo sapiens A2780 Ratio IC50 26.8 None 10.1021/jm500849z
Homo sapiens A2780 Ratio IC50 116.0 None 10.1016/j.bmc.2014.02.036
Homo sapiens A2780 Ratio IC50 116.0 None 10.1021/jm800086e
Homo sapiens A2780 Ratio IC50 196.0 None 10.1021/jm500024v
Homo sapiens A2780 Ratio IC50 208.0 None 10.1021/jm901249g
Homo sapiens A2780 Ratio IC50 386.0 None 10.1016/j.bmc.2014.02.036
Homo sapiens A2780 Ratio IC50 386.0 None 10.1021/jm800086e
Homo sapiens A2780 Ratio IC50 400.0 None 10.1016/j.ejmech.2013.01.007
Homo sapiens A2780 Ratio IC50 575.0 None 10.1016/j.bmcl.2007.03.026
Homo sapiens A2780 Ratio IC50 753.0 None 10.1016/j.bmcl.2008.12.018
Homo sapiens A2780 Ratio IC50 900.0 None 10.1016/j.bmcl.2012.09.104
Homo sapiens A2780 Ratio IC50 1136.0 None 10.1021/acs.jmedchem.6b00021
Homo sapiens A2780 Ratio IC50 1157.0 None 10.1016/j.ejmech.2011.02.011
Homo sapiens A2780 Ratio IC50 3064.0 None 10.1016/j.bmcl.2011.06.034
Homo sapiens A2780 Ratio IC50 10470.0 None 10.1016/j.bmcl.2009.04.070
Homo sapiens A2780 Ratio IC50 10470.0 None 10.1021/np8006556
Homo sapiens A2780 TGI nan None 10.1021/acs.jnatprod.7b00857
Homo sapiens A2780cisR Activity 21.3 % 10.1016/j.bmc.2019.115044
Homo sapiens A2780S Activity 79.4 % 10.1021/acs.jmedchem.1c01451
Homo sapiens A2780S IC50 5.62 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens A2780S IC50 7.5 nM 10.1021/acs.jmedchem.0c01837
Homo sapiens A2780S IC50 12.3 nM 10.1016/j.ejmech.2017.07.040
Homo sapiens A2780S IC50 18.94 nM 10.1016/j.ejmech.2018.05.003
Homo sapiens A2780S IC50 58.1 nM 10.1021/acs.jmedchem.6b00158
Homo sapiens A2780S IC50 60.4 nM 10.1021/acs.jmedchem.1c02159
Homo sapiens A2780S TGI 66.06 % 10.1021/acs.jmedchem.1c02159
Homo sapiens A2780S TGI 82.9 % 10.1021/acs.jmedchem.6b00158
Homo sapiens A2780S TGI 85.0 % 10.1021/acs.jmedchem.6b00158
Homo sapiens A2780/Taxol Activity 35.3 % 10.1021/acs.jmedchem.1c01451
Homo sapiens A2780/Taxol IC50 500.0 nM 10.1016/j.ejmech.2020.112323
Homo sapiens A2780/Taxol IC50 3164.0 nM 10.1021/acs.jmedchem.0c01837
Homo sapiens A2780/Taxol IC50 3422.0 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens A2780/Taxol IC50 25120.0 nM 10.1016/j.ejmech.2017.07.040
Homo sapiens A2780/Taxol IC50 56600.0 nM 10.1021/acs.jmedchem.6b00158
Homo sapiens A2780/Taxol IC50 58855.0 nM 10.1021/acs.jmedchem.1c02159
Homo sapiens A2780/Taxol IC50 72967.46 nM 10.1016/j.ejmech.2018.05.003
Homo sapiens A2780/Taxol Inhibition nan % 10.1021/acs.jmedchem.0c01837
Homo sapiens A2780/Taxol TGI 21.7 % 10.1021/acs.jmedchem.1c02159
Homo sapiens A2780/Taxol TGI 26.94 % 10.1021/acs.jmedchem.1c02159
Homo sapiens A2780/Taxol TGI 37.2 % 10.1021/acs.jmedchem.1c02159
Homo sapiens A2780/Taxol TGI 37.7 % 10.1021/acs.jmedchem.6b00158
Homo sapiens A2780/Taxol TGI 75.73 % 10.1021/acs.jmedchem.1c02159
Homo sapiens A-375 Activity 0.78 g 10.1016/j.ejmech.2018.02.045
Homo sapiens A-375 Activity 18.1 % 10.1021/acs.jmedchem.1c01123
Homo sapiens A-375 Activity 19.3 % 10.1021/acs.jmedchem.1c01123
Homo sapiens A-375 Activity 20.0 % 10.1021/acs.jmedchem.1c01123
Homo sapiens A-375 Activity 62.3 % 10.1021/acs.jmedchem.8b00827
Homo sapiens A-375 Activity nan None 10.1016/j.bmc.2009.05.006
Homo sapiens A-375 Activity nan None 10.1021/acs.jmedchem.1c01123
Homo sapiens A-375 Activity nan None 10.1021/acs.jmedchem.7b01858
Homo sapiens A-375 Activity nan None 10.1021/acs.jmedchem.8b00827
Homo sapiens A-375 GI 96.22 % 10.1016/j.bmc.2013.11.037
Homo sapiens A-375 GI50 10.0 nM 10.1016/j.bmc.2020.115433
Homo sapiens A-375 IC50 1.6 nM 10.1021/acs.jmedchem.1c00715
Homo sapiens A-375 IC50 1.7 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens A-375 IC50 2.0 nM 10.1021/acs.jmedchem.8b01742
Homo sapiens A-375 IC50 4.6 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens A-375 IC50 4.9 nM 10.1021/np2004038
Homo sapiens A-375 IC50 8.9 nM 10.1021/np200431k
Homo sapiens A-375 IC50 8.9 nM 10.1021/np5009569
Homo sapiens A-375 IC50 9.2 nM 10.1021/np3003639
Homo sapiens A-375 IC50 10.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens A-375 IC50 47.8 nM 10.1016/j.ejmech.2018.07.043
Homo sapiens A-375 IC50 100.0 nM 10.1021/acs.jmedchem.1c01123
Homo sapiens A-375 IC50 100.0 nM 10.1021/acs.jmedchem.8b01445
Homo sapiens A-375 IC50 680.0 nM 10.1039/C6MD00256K
Homo sapiens A-375 IC50 700.0 nM 10.1016/j.ejmech.2017.06.043
Homo sapiens A-375 IC50 810.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens A-375 IC50 810.0 nM 10.1016/j.ejmech.2009.12.060
Homo sapiens A-375 IC50 810.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens A-375 IC50 810.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens A-375 IC50 8000.0 nM 10.1016/j.bmcl.2014.11.083
Homo sapiens A-375 IC50 11260.0 nM 10.1016/j.ejmech.2016.10.012
Homo sapiens A-375 IC50 15800.0 nM 10.1021/acs.jmedchem.8b01445
Homo sapiens A-375 IC50 nan None 10.1016/j.bmc.2007.05.070
Homo sapiens A-375 Inhibition nan % 10.1021/acs.jmedchem.8b01445
Homo sapiens A-375 TGI 68.6 % 10.1021/acs.jmedchem.9b00706
Homo sapiens A-375 TGI 70.6 % 10.1016/j.ejmech.2018.02.045
Homo sapiens A-375 TGI 70.7 % 10.1021/acs.jmedchem.8b00827
Homo sapiens A-375 TGI 76.5 % 10.1021/acs.jmedchem.7b01858
Homo sapiens A388 IC50 8.738 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 73.51 nM 10.6019/CHEMBL1201861
Homo sapiens A-427 Log IC50 -8.2 nM 10.1021/jm049405a
Homo sapiens A-431 EC50 9.0 nM 10.1016/j.bmcl.2005.11.094
Homo sapiens A-431 ED50 0.01 ug ml-1 10.1016/j.bmcl.2007.06.083
Homo sapiens A-431 GI50 0.0023 ug.mL-1 10.1016/j.bmcl.2015.11.071
Homo sapiens A-431 GI50 0.01 nM 10.1016/j.bmcl.2009.04.020
Homo sapiens A-431 GI50 2.355 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens A-431 IC50 1.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens A-431 IC50 2.0 nM 10.1016/j.bmc.2019.115281
Homo sapiens A-431 IC50 7.0 nM 10.1016/j.bmcl.2014.07.035
Homo sapiens A-431 IC50 9.2 nM 10.1021/jm101388d
Homo sapiens A-431 IC50 25.1 nM 10.1016/j.bmcl.2008.10.077
Homo sapiens A-431 MIC 0.027 ug.mL-1 10.1016/j.bmcl.2015.11.071
Homo sapiens A498 GI50 7.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens A498 GI50 7.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens A498 GI50 79.43 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens A498 GI50 107.4 nM None
Homo sapiens A498 GI50 3500.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens A498 IC50 0.003 ug.mL-1 10.1016/j.bmc.2007.03.041
Homo sapiens A498 IC50 0.003 ug.mL-1 10.1021/jm0009078
Homo sapiens A498 IC50 7.53 ug.mL-1 10.1016/j.ejmech.2014.10.013
Homo sapiens A498 IC50 17.0 nM 10.1021/jm050996u
Homo sapiens A498 IC50 61.0 nM 10.1016/j.bmcl.2006.11.008
Homo sapiens A498 IC50 1215.34 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 8810.0 nM 10.1021/jm8006257
Homo sapiens A498 IC90 229.0 nM 10.1021/jm050996u
Homo sapiens A498 Inhibition 98.2 % 10.1021/np040132w
Homo sapiens A498 Log IC50 -7.3 nM 10.1021/jm049405a
Homo sapiens A4-Fuk IC50 6.109 nM 10.6019/CHEMBL1201861
Homo sapiens A549 Activity 0.0 % 10.1021/np060597h
Homo sapiens A549 Activity 0.17 g 10.1016/j.bmcl.2011.11.083
Homo sapiens A549 Activity 1.0 % 10.1021/acs.jmedchem.8b01590
Homo sapiens A549 Activity 1.2 % 10.1021/acs.jmedchem.8b01590
Homo sapiens A549 Activity 1.56 % 10.1021/np060597h
Homo sapiens A549 Activity 2.9 % 10.1021/acs.jmedchem.8b01590
Homo sapiens A549 Activity 5.86 % 10.1016/j.ejmech.2018.05.028
Homo sapiens A549 Activity 6.01 % 10.1016/j.bmcl.2015.04.053
Homo sapiens A549 Activity 8.4 % 10.1038/nchembio853
Homo sapiens A549 Activity 8.85 % 10.1038/nchembio853
Homo sapiens A549 Activity 9.81 % 10.1016/j.bmcl.2015.04.053
Homo sapiens A549 Activity 13.7 % 10.1016/j.bmcl.2015.04.053
Homo sapiens A549 Activity 16.1 % 10.1038/nchembio853
Homo sapiens A549 Activity 22.9 mm3 10.1016/j.bmcl.2011.11.083
Homo sapiens A549 Activity 24.56 % 10.1016/j.ejmech.2018.05.028
Homo sapiens A549 Activity 36.9 % 10.1038/nchembio853
Homo sapiens A549 Activity 45.0 % 10.1016/j.ejmech.2014.11.068
Homo sapiens A549 Activity 70.48 % 10.1016/j.bmcl.2015.04.053
Homo sapiens A549 Activity 74.17 % 10.1016/j.ejmech.2018.05.028
Homo sapiens A549 Activity 82.0 % 10.1021/np3006666
Homo sapiens A549 Activity 94.9 % 10.1021/acs.jmedchem.8b01590
Homo sapiens A549 Activity 98.44 % 10.1021/np060597h
Homo sapiens A549 Activity 100.0 % 10.1021/jm0204136
Homo sapiens A549 Activity nan None 10.1007/s00044-012-0424-0
Homo sapiens A549 Activity nan None 10.1016/j.bmc.2011.07.040
Homo sapiens A549 Activity nan None 10.1016/j.ejmech.2020.112896
Homo sapiens A549 Activity nan None 10.1021/acs.jmedchem.2c01306
Homo sapiens A549 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens A549 Activity nan None 10.1021/jm501518y
Homo sapiens A549 CC50 20.0 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens A549 Combination_index 1.349 None 10.1016/j.bmcl.2003.12.015
Homo sapiens A549 Combination_index 1.539 None 10.1016/j.bmcl.2003.12.015
Homo sapiens A549 Combination_index 2.234 None 10.1016/j.bmcl.2003.12.015
Homo sapiens A549 Cytotoxicity 4.3 ng ml-1 10.1021/jm00009a009
Homo sapiens A549 EC50 0.005 ug.mL-1 10.1016/j.bmcl.2008.06.099
Homo sapiens A549 EC50 0.005 ug.mL-1 10.1021/np800622a
Homo sapiens A549 EC50 4.6 nM 10.1016/j.bmc.2011.07.040
Homo sapiens A549 EC50 6.4 nM 10.1016/j.bmcl.2011.11.026
Homo sapiens A549 ED50 0.005 ug ml-1 10.1021/jm020548b
Homo sapiens A549 ED50 0.005 ug ml-1 10.1021/np030241v
Homo sapiens A549 ED50 0.008 uM 10.1021/np100406d
Homo sapiens A549 ED50 0.02 ug ml-1 10.1016/j.bmc.2007.03.041
Homo sapiens A549 ED50 0.02 ug ml-1 10.1016/j.bmcl.2007.06.083
Homo sapiens A549 ED50 2.3 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens A549 ED50 2.56 nM 10.1016/j.bmc.2011.01.001
Homo sapiens A549 GI 12.0 % None
Homo sapiens A549 GI 40.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens A549 GI 41.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens A549 GI 44.0 % 10.1007/s00044-012-0106-y
Homo sapiens A549 GI 50.0 % 10.1016/j.bmcl.2010.01.147
Homo sapiens A549 GI 51.0 % 10.1016/j.ejmech.2009.10.042
Homo sapiens A549 GI 52.0 % 10.1016/j.bmcl.2009.10.097
Homo sapiens A549 GI 53.0 % 10.1016/j.bmcl.2011.11.083
Homo sapiens A549 GI 54.0 % 10.1007/s00044-010-9410-6
Homo sapiens A549 GI 54.0 % None
Homo sapiens A549 GI 56.0 % 10.1016/j.bmcl.2013.11.032
Homo sapiens A549 GI 59.0 % 10.1007/s00044-012-0312-7
Homo sapiens A549 GI 67.0 % 10.1007/s00044-011-9887-7
Homo sapiens A549 GI 67.0 % 10.1016/j.ejmech.2009.11.001
Homo sapiens A549 GI 69.0 % 10.1016/j.bmc.2012.02.057
Homo sapiens A549 GI 69.0 % 10.1016/j.ejmech.2011.10.033
Homo sapiens A549 GI 69.0 % 10.1016/j.ejmech.2012.06.057
Homo sapiens A549 GI 70.0 % 10.1016/j.ejmech.2014.08.005
Homo sapiens A549 GI 78.0 % 10.1016/j.ejmech.2016.11.037
Homo sapiens A549 GI 86.0 % None
Homo sapiens A549 GI 97.0 % None
Homo sapiens A549 GI 114.0 % None
Homo sapiens A549 GI nan None 10.1016/j.bmc.2012.07.031
Homo sapiens A549 GI50 0.0023 ug.mL-1 10.1016/j.bmcl.2015.11.071
Homo sapiens A549 GI50 0.0035 ug.mL-1 10.1016/j.bmcl.2015.08.006
Homo sapiens A549 GI50 0.0035 ug.mL-1 10.1016/j.bmcl.2017.01.004
Homo sapiens A549 GI50 0.0035 ug.mL-1 10.1016/j.bmcl.2019.03.020
Homo sapiens A549 GI50 0.0035 ug.mL-1 10.1016/j.ejmech.2017.01.009
Homo sapiens A549 GI50 0.0035 ug.mL-1 10.1016/j.ejmech.2017.03.065
Homo sapiens A549 GI50 0.0035 ug.mL-1 10.1039/C5MD00404G
Homo sapiens A549 GI50 0.004 ug.mL-1 10.1016/j.bmcl.2016.03.045
Homo sapiens A549 GI50 0.039 ug.mL-1 10.1016/j.bmcl.2016.02.056
Homo sapiens A549 GI50 0.12 ug.mL-1 10.1016/j.bmcl.2016.02.043
Homo sapiens A549 GI50 0.13 ug.mL-1 10.1039/C5MD00057B
Homo sapiens A549 GI50 0.6 nM 10.1021/acsmedchemlett.1c00505
Homo sapiens A549 GI50 2.4 nM 10.1021/acsmedchemlett.9b00352
Homo sapiens A549 GI50 3.54 nM None
Homo sapiens A549 GI50 3.7 nM 10.1021/acsmedchemlett.7b00131
Homo sapiens A549 GI50 4.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens A549 GI50 4.0 nM 10.1021/jm061288r
Homo sapiens A549 GI50 4.89 nM 10.1016/j.bmcl.2012.08.014
Homo sapiens A549 GI50 5.46 nM 10.1016/j.ejmech.2011.12.025
Homo sapiens A549 GI50 5.58 nM 10.1016/j.bmc.2011.01.034
Homo sapiens A549 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens A549 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens A549 GI50 7.03 nM 10.1021/acs.jmedchem.7b00273
Homo sapiens A549 GI50 7.1 nM 10.1016/j.bmcl.2015.02.018
Homo sapiens A549 GI50 7.6 nM 10.1016/j.bmc.2011.02.004
Homo sapiens A549 GI50 7.6 nM 10.1016/j.bmc.2013.11.018
Homo sapiens A549 GI50 7.6 nM 10.1016/j.bmc.2015.07.016
Homo sapiens A549 GI50 7.6 nM 10.1016/j.ejmech.2013.06.041
Homo sapiens A549 GI50 7.6 nM 10.1021/jm4016526
Homo sapiens A549 GI50 8.18 nM 10.1016/j.bmc.2012.11.047
Homo sapiens A549 GI50 10.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens A549 GI50 10.0 nM 10.1016/j.bmcl.2015.03.032
Homo sapiens A549 GI50 10.0 nM 10.1016/j.ejmech.2016.02.059
Homo sapiens A549 GI50 18.73 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens A549 GI50 60.0 nM 10.1021/jm300705j
Homo sapiens A549 GI50 2600.0 nM 10.1016/j.bmc.2016.05.025
Homo sapiens A549 GI50 80000.0 nM 10.1039/C6MD00278A
Homo sapiens A549 GI50 nan None 10.1016/j.bmcl.2009.04.020
Homo sapiens A549 GI90 0.004 ug ml-1 10.1016/j.bmcl.2016.02.056
Homo sapiens A549 GI90 0.038 ug ml-1 10.1016/j.bmcl.2016.03.045
Homo sapiens A549 GI90 0.0706 ug ml-1 10.1016/j.bmcl.2015.08.006
Homo sapiens A549 GI90 0.0706 ug ml-1 10.1016/j.bmcl.2017.01.004
Homo sapiens A549 GI90 0.0706 ug ml-1 10.1016/j.bmcl.2019.03.020
Homo sapiens A549 GI90 0.0706 ug ml-1 10.1016/j.ejmech.2017.03.065
Homo sapiens A549 GI90 5.72 ug ml-1 10.1039/C5MD00057B
Homo sapiens A549 GI90 5.88 ug ml-1 10.1016/j.bmcl.2016.02.043
Homo sapiens A549 IC50 0.00029 ug.mL-1 10.1016/j.bmcl.2008.12.091
Homo sapiens A549 IC50 0.0019 ug.mL-1 10.1016/j.bmcl.2012.04.084
Homo sapiens A549 IC50 0.002 ug.mL-1 10.1016/j.bmcl.2004.10.097
Homo sapiens A549 IC50 0.002 ug.mL-1 10.1021/np900620y
Homo sapiens A549 IC50 0.0034 ug.mL-1 10.1016/S0960-894X(01)80507-2
Homo sapiens A549 IC50 0.0052 ug.mL-1 10.1016/j.bmcl.2011.12.024
Homo sapiens A549 IC50 0.01964 ug.mL-1 10.1016/j.bmc.2008.12.030
Homo sapiens A549 IC50 0.02 ug.mL-1 10.1016/j.bmcl.2012.08.074
Homo sapiens A549 IC50 0.03 nM 10.1016/j.bmcl.2015.09.010
Homo sapiens A549 IC50 0.99 nM 10.1021/acs.jnatprod.6b00645
Homo sapiens A549 IC50 1.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens A549 IC50 1.0 nM 10.1016/j.bmcl.2020.127557
Homo sapiens A549 IC50 1.0 nM 10.1021/np900089v
Homo sapiens A549 IC50 1.1 nM 10.1016/j.ejmech.2022.114466
Homo sapiens A549 IC50 1.4 nM 10.1021/jm0204136
Homo sapiens A549 IC50 1.93 nM 10.1016/j.bmcl.2009.12.041
Homo sapiens A549 IC50 2.0 nM 10.1016/j.bmcl.2008.07.116
Homo sapiens A549 IC50 2.0 ug.mL-1 10.1021/np800167x
Homo sapiens A549 IC50 2.1 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens A549 IC50 2.1 nM 10.1021/jm060197r
Homo sapiens A549 IC50 2.12 nM 10.1021/acs.jnatprod.5b00650
Homo sapiens A549 IC50 2.2 nM 10.1016/j.bmcl.2020.127168
Homo sapiens A549 IC50 2.3 nM 10.1016/j.bmc.2015.04.055
Homo sapiens A549 IC50 2.3 nM 10.1021/jm101388d
Homo sapiens A549 IC50 2.3 nM 10.1021/np900302w
Homo sapiens A549 IC50 2.4 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens A549 IC50 2.9 nM 10.1016/j.bmcl.2004.06.080
Homo sapiens A549 IC50 3.0 nM 10.1016/j.bmcl.2004.05.027
Homo sapiens A549 IC50 3.0 nM 10.1016/j.bmcl.2015.01.056
Homo sapiens A549 IC50 3.0 nM 10.1016/j.ejmech.2021.113685
Homo sapiens A549 IC50 3.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens A549 IC50 3.0 nM 10.1021/jm025540g
Homo sapiens A549 IC50 3.14 nM 10.1021/jm200692n
Homo sapiens A549 IC50 3.2 nM 10.1021/acs.jnatprod.7b01006
Homo sapiens A549 IC50 3.3 nM 10.1016/j.ejmech.2019.111587
Homo sapiens A549 IC50 3.4 nM 10.1021/acs.jmedchem.8b01742
Homo sapiens A549 IC50 3.5 nM 10.1021/jm400043d
Homo sapiens A549 IC50 3.6 nM 10.1016/S0960-894X(01)80298-5
Homo sapiens A549 IC50 3.6 nM 10.1016/S0960-894X(01)80568-0
Homo sapiens A549 IC50 3.6 nM 10.1016/S0960-894X(96)00595-1
Homo sapiens A549 IC50 3.6 nM 10.1021/jm00036a004
Homo sapiens A549 IC50 3.6 nM 10.1021/jm025540g
Homo sapiens A549 IC50 3.6 nM 10.1021/jm9604080
Homo sapiens A549 IC50 3.6 nM 10.1021/jm960563e
Homo sapiens A549 IC50 3.6 nM 10.1021/jm9606711
Homo sapiens A549 IC50 3.6 nM 10.1021/np300897v
Homo sapiens A549 IC50 3.6 nM 10.1038/nchembio853
Homo sapiens A549 IC50 3.8 nM 10.1016/j.bmc.2020.115792
Homo sapiens A549 IC50 3.8 nM 10.1016/j.bmcl.2010.07.100
Homo sapiens A549 IC50 4.0 nM 10.1021/acs.jmedchem.8b01445
Homo sapiens A549 IC50 4.1 nM 10.1021/acsmedchemlett.7b00117
Homo sapiens A549 IC50 4.4 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens A549 IC50 4.4 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens A549 IC50 4.4 nM 10.1016/j.ejmech.2013.10.033
Homo sapiens A549 IC50 4.5 nM 10.1021/acs.jnatprod.7b00949
Homo sapiens A549 IC50 4.7 nM 10.1016/j.bmcl.2021.128355
Homo sapiens A549 IC50 4.79 ug.mL-1 10.1021/np50078a018
Homo sapiens A549 IC50 4.9 nM 10.1016/j.ejmech.2010.01.051
Homo sapiens A549 IC50 4.9 nM 10.1016/j.ejmech.2010.09.061
Homo sapiens A549 IC50 4.9 nM 10.1021/jm050996u
Homo sapiens A549 IC50 4.97 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens A549 IC50 5.0 nM 10.1021/acs.jnatprod.0c00064
Homo sapiens A549 IC50 5.0 nM 10.1021/jm500024v
Homo sapiens A549 IC50 5.2 nM 10.1021/np800716f
Homo sapiens A549 IC50 5.7 nM 10.1016/j.bmcl.2014.06.060
Homo sapiens A549 IC50 5.7 nM 10.1016/j.ejmech.2021.113578
Homo sapiens A549 IC50 6.0 nM 10.1016/j.bmcl.2021.128319
Homo sapiens A549 IC50 6.0 nM 10.1016/j.ejmech.2014.10.075
Homo sapiens A549 IC50 6.0 nM 10.1016/j.ejmech.2022.114112
Homo sapiens A549 IC50 6.0 nM 10.1021/jm0510676
Homo sapiens A549 IC50 6.0 nM 10.1021/jm070534b
Homo sapiens A549 IC50 6.2 nM 10.1016/j.bmc.2019.05.016
Homo sapiens A549 IC50 6.2 nM 10.1021/acs.jnatprod.6b01151
Homo sapiens A549 IC50 6.2 nM 10.1021/acs.jnatprod.6b01153
Homo sapiens A549 IC50 6.2 nM 10.1021/acs.jnatprod.7b00578
Homo sapiens A549 IC50 6.3 nM 10.1016/j.ejmech.2015.09.019
Homo sapiens A549 IC50 6.3 nM 10.1021/acs.jnatprod.8b00211
Homo sapiens A549 IC50 6.3 nM 10.1021/acs.jnatprod.9b00596
Homo sapiens A549 IC50 6.5 nM 10.1021/acs.jnatprod.0c00454
Homo sapiens A549 IC50 6.8 nM 10.1021/acs.jnatprod.6b00873
Homo sapiens A549 IC50 6.85 nM 10.1016/j.bmcl.2017.04.055
Homo sapiens A549 IC50 7.0 nM 10.1016/j.ejmech.2018.02.062
Homo sapiens A549 IC50 7.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens A549 IC50 7.0 nM 10.1021/jm3013097
Homo sapiens A549 IC50 7.0 nM 10.1021/np0704957
Homo sapiens A549 IC50 7.1 nM 10.1016/j.bmcl.2018.02.006
Homo sapiens A549 IC50 7.2 nM 10.1016/j.bmc.2012.10.001
Homo sapiens A549 IC50 7.2 nM 10.1016/j.ejmech.2011.10.013
Homo sapiens A549 IC50 7.2 nM 10.1021/jm200392p
Homo sapiens A549 IC50 7.52 nM 10.1016/j.ejmech.2019.111696
Homo sapiens A549 IC50 8.0 nM 10.1016/j.bmc.2021.116495
Homo sapiens A549 IC50 8.0 nM 10.1016/j.bmcl.2018.05.038
Homo sapiens A549 IC50 8.0 nM 10.1016/j.ejmech.2019.02.025
Homo sapiens A549 IC50 8.0 nM 10.1016/j.ejmech.2022.114355
Homo sapiens A549 IC50 8.0 nM 10.1016/j.ejmech.2022.114844
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.0c00298
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.1c00342
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.5b00057
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.6b00508
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.7b00150
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.7b00163
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.7b00514
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.7b00723
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.7b00909
Homo sapiens A549 IC50 8.0 nM 10.1021/acs.jnatprod.9b00183
Homo sapiens A549 IC50 8.0 nM 10.1021/np200140j
Homo sapiens A549 IC50 8.0 nM 10.1021/np300772e
Homo sapiens A549 IC50 8.0 nM 10.1021/np400041y
Homo sapiens A549 IC50 8.0 nM 10.1021/np4005823
Homo sapiens A549 IC50 8.0 nM 10.1021/np400600c
Homo sapiens A549 IC50 8.0 nM 10.1021/np400669t
Homo sapiens A549 IC50 8.0 nM 10.1021/np4010135
Homo sapiens A549 IC50 8.0 nM 10.1021/np5005196
Homo sapiens A549 IC50 8.0 nM 10.1021/np500626x
Homo sapiens A549 IC50 8.0 nM 10.1021/np501057f
Homo sapiens A549 IC50 8.2 nM 10.1021/jm301864s
Homo sapiens A549 IC50 8.76 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens A549 IC50 9.0 nM 10.1021/acs.jmedchem.6b00021
Homo sapiens A549 IC50 9.0 nM 10.1021/jm500024v
Homo sapiens A549 IC50 9.52 nM 10.1016/j.ejmech.2017.03.031
Homo sapiens A549 IC50 9.8 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens A549 IC50 10.0 nM 10.1016/j.bmcl.2013.07.032
Homo sapiens A549 IC50 10.0 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens A549 IC50 10.0 nM 10.1021/np2002918
Homo sapiens A549 IC50 12.0 nM 10.1016/j.ejmech.2020.112519
Homo sapiens A549 IC50 12.0 nM 10.1016/s0960-894x(02)00118-x
Homo sapiens A549 IC50 12.6 nM 10.1021/np070256j
Homo sapiens A549 IC50 13.0 nM 10.1016/j.bmc.2020.115736
Homo sapiens A549 IC50 13.0 nM 10.1016/j.bmcl.2005.10.022
Homo sapiens A549 IC50 13.2 nM 10.1021/acsmedchemlett.5b00418
Homo sapiens A549 IC50 13.7 nM 10.1021/acs.jnatprod.8b01084
Homo sapiens A549 IC50 14.0 nM 10.1016/j.bmcl.2013.06.077
Homo sapiens A549 IC50 15.0 nM 10.1016/j.bmcl.2006.02.035
Homo sapiens A549 IC50 15.0 nM 10.1016/j.ejmech.2021.113629
Homo sapiens A549 IC50 15.0 nM 10.1039/d1md00392e
Homo sapiens A549 IC50 16.0 nM 10.1016/j.bmcl.2010.07.085
Homo sapiens A549 IC50 16.0 nM 10.1016/j.bmcl.2011.04.030
Homo sapiens A549 IC50 16.0 nM 10.1021/np200920c
Homo sapiens A549 IC50 16.0 nM 10.1021/np3000443
Homo sapiens A549 IC50 16.0 nM 10.1021/np3008864
Homo sapiens A549 IC50 18.0 nM 10.1016/j.ejmech.2018.11.070
Homo sapiens A549 IC50 19.0 nM 10.1021/np0701531
Homo sapiens A549 IC50 20.0 nM 10.1021/acs.jnatprod.6b00306
Homo sapiens A549 IC50 20.0 nM 10.1021/np400070x
Homo sapiens A549 IC50 20.0 nM 10.1021/np400379u
Homo sapiens A549 IC50 20.0 nM 10.1021/np4004068
Homo sapiens A549 IC50 23.0 nM 10.1016/j.ejmech.2017.03.055
Homo sapiens A549 IC50 23.1 nM 10.1016/j.bmcl.2008.06.066
Homo sapiens A549 IC50 23.18 nM 10.1016/j.ejmech.2018.05.003
Homo sapiens A549 IC50 24.2 nM 10.1021/acs.jmedchem.1c02159
Homo sapiens A549 IC50 25.0 nM 10.1016/j.ejmech.2014.11.068
Homo sapiens A549 IC50 28.0 nM 10.1016/j.bmcl.2006.02.035
Homo sapiens A549 IC50 28.0 nM 10.1021/jm050920y
Homo sapiens A549 IC50 29.5 nM 10.1016/j.bmc.2021.116551
Homo sapiens A549 IC50 30.0 nM 10.1021/acs.jmedchem.1c01775
Homo sapiens A549 IC50 30.0 nM 10.1021/np200431k
Homo sapiens A549 IC50 30.0 nM 10.1021/np5009569
Homo sapiens A549 IC50 32.0 nM 10.1021/np400851k
Homo sapiens A549 IC50 44.9 nM 10.1021/np2004038
Homo sapiens A549 IC50 50.0 nM 10.1021/acs.jnatprod.1c01194
Homo sapiens A549 IC50 51.0 nM 10.1021/acs.jnatprod.8b00197
Homo sapiens A549 IC50 56.0 nM 10.1021/np300551g
Homo sapiens A549 IC50 58.0 nM 10.1016/j.bmc.2015.02.004
Homo sapiens A549 IC50 58.0 nM 10.1016/j.ejmech.2022.114372
Homo sapiens A549 IC50 58.5 nM 10.1016/j.bmcl.2018.12.004
Homo sapiens A549 IC50 67.5 nM 10.1021/acs.jnatprod.1c01050
Homo sapiens A549 IC50 70.0 nM 10.1021/acs.jmedchem.1c01775
Homo sapiens A549 IC50 82.0 nM 10.1016/j.ejmech.2014.07.035
Homo sapiens A549 IC50 100.0 nM 10.1016/j.ejmech.2022.114439
Homo sapiens A549 IC50 100.0 nM 10.1021/np400287r
Homo sapiens A549 IC50 100.0 nM 10.1021/np800484j
Homo sapiens A549 IC50 100.0 nM 10.1021/np9000366
Homo sapiens A549 IC50 110.0 nM 10.1016/j.ejmech.2019.01.076
Homo sapiens A549 IC50 190.0 nM 10.1016/j.bmc.2012.03.001
Homo sapiens A549 IC50 290.0 nM 10.1039/D1MD00125F
Homo sapiens A549 IC50 350.0 nM 10.1016/j.ejmech.2019.111587
Homo sapiens A549 IC50 390.0 nM 10.1016/j.ejmech.2019.06.006
Homo sapiens A549 IC50 390.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens A549 IC50 400.0 nM 10.1039/C6MD00256K
Homo sapiens A549 IC50 520.0 nM 10.1016/j.bmc.2015.04.055
Homo sapiens A549 IC50 540.0 nM 10.1016/j.ejmech.2019.01.005
Homo sapiens A549 IC50 700.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens A549 IC50 700.0 nM 10.1021/acs.jmedchem.8b01424
Homo sapiens A549 IC50 700.0 nM 10.1021/acs.jnatprod.0c00919
Homo sapiens A549 IC50 720.0 nM 10.1021/np3003639
Homo sapiens A549 IC50 740.0 nM 10.1039/C4MD00573B
Homo sapiens A549 IC50 930.0 nM 10.1016/j.bmcl.2013.10.007
Homo sapiens A549 IC50 930.0 nM 10.1021/np0704708
Homo sapiens A549 IC50 960.0 nM 10.1016/s0960-894x(02)00118-x
Homo sapiens A549 IC50 1037.8 nM 10.1021/jm301864s
Homo sapiens A549 IC50 1040.0 nM 10.1021/np5004559
Homo sapiens A549 IC50 1160.0 nM 10.1016/j.bmc.2012.03.001
Homo sapiens A549 IC50 1250.0 nM 10.1021/np030481a
Homo sapiens A549 IC50 1400.0 nM 10.1021/np100110u
Homo sapiens A549 IC50 1400.0 nM 10.1021/np400190n
Homo sapiens A549 IC50 1525.0 nM 10.1016/j.ejmech.2014.05.043
Homo sapiens A549 IC50 1700.0 nM 10.1016/j.bmcl.2004.09.025
Homo sapiens A549 IC50 1920.0 nM 10.1016/j.bmcl.2016.09.002
Homo sapiens A549 IC50 2100.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens A549 IC50 2280.0 nM 10.1016/j.ejmech.2009.09.017
Homo sapiens A549 IC50 2400.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens A549 IC50 2460.0 nM 10.1016/j.bmc.2009.03.037
Homo sapiens A549 IC50 2460.0 nM 10.1016/j.bmc.2010.10.047
Homo sapiens A549 IC50 2460.0 nM 10.1016/j.ejmech.2011.01.057
Homo sapiens A549 IC50 2700.0 nM 10.1007/s00044-012-0424-0
Homo sapiens A549 IC50 2700.0 nM 10.1016/j.ejmech.2009.11.001
Homo sapiens A549 IC50 2700.0 nM 10.1039/C3MD00055A
Homo sapiens A549 IC50 2820.0 nM 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 IC50 3460.0 nM 10.1016/j.ejmech.2012.03.024
Homo sapiens A549 IC50 3760.0 nM 10.1016/j.bmcl.2021.128503
Homo sapiens A549 IC50 4900.0 nM 10.1016/j.bmcl.2014.11.083
Homo sapiens A549 IC50 5400.0 nM 10.1021/acs.jnatprod.0c00698
Homo sapiens A549 IC50 5500.0 nM 10.1021/acs.jnatprod.6b00561
Homo sapiens A549 IC50 5820.0 nM 10.1039/C7MD00310B
Homo sapiens A549 IC50 6195.0 nM 10.1016/j.ejmech.2017.02.025
Homo sapiens A549 IC50 6200.0 nM 10.1021/acs.jnatprod.9b00659
Homo sapiens A549 IC50 6800.0 nM 10.1016/j.ejmech.2018.08.069
Homo sapiens A549 IC50 9265.0 nM 10.1016/j.bmcl.2011.06.036
Homo sapiens A549 IC50 10000.0 nM 10.1016/j.bmcl.2016.02.041
Homo sapiens A549 IC50 13050.0 nM 10.1016/j.bmc.2008.07.066
Homo sapiens A549 IC50 21020.0 nM 10.1039/C6MD00234J
Homo sapiens A549 IC50 30000.0 nM 10.1016/j.ejmech.2018.05.028
Homo sapiens A549 IC50 854000.0 nM 10.1016/j.bmcl.2020.127328
Homo sapiens A549 IC50 nan None 10.1016/j.bmc.2007.05.070
Homo sapiens A549 IC50 nan None 10.1016/j.ejmech.2018.07.029
Homo sapiens A549 IC90 41.0 nM 10.1021/jm050996u
Homo sapiens A549 Inhibition 3.6 % 10.1016/s0960-894x(99)00161-4
Homo sapiens A549 Inhibition 79.7 % 10.1021/np040132w
Homo sapiens A549 Log IC50 -8.1 nM 10.1021/jm049405a
Homo sapiens A549 MIC 0.039 ug.mL-1 10.1016/j.bmcl.2015.11.071
Homo sapiens A549 Ratio 1.0 None 10.1016/s0960-894x(03)00054-4
Homo sapiens A549 Ratio IC50 1.8 None 10.1021/jm500024v
Homo sapiens A549 Ratio IC50 2.33 None 10.1021/acs.jmedchem.1c01775
Homo sapiens A549 Ratio IC50 2.56 None 10.1021/acs.jmedchem.6b00021
Homo sapiens A549 Ratio IC50 6.1 None 10.1016/j.bmc.2012.03.001
Homo sapiens A549 Ratio IC50 10.2 uM 10.1021/jm070534b
Homo sapiens A549 Ratio IC50 10.4 None 10.1016/j.bmc.2012.10.001
Homo sapiens A549 Ratio IC50 10.4 None 10.1016/j.ejmech.2011.10.013
Homo sapiens A549 Ratio IC50 10.4 None 10.1021/jm200392p
Homo sapiens A549 Ratio IC50 17.0 uM 10.1021/jm070534b
Homo sapiens A549 Ratio IC50 26.0 None 10.1021/jm400043d
Homo sapiens A549 Ratio IC50 126.6 None 10.1021/jm301864s
Homo sapiens A549 Ratio IC50 173.0 None 10.1016/j.bmc.2015.04.055
Homo sapiens A549 TGI 53.8 % 10.1021/acs.jmedchem.2c01208
Homo sapiens A549 TGI 54.0 % 10.1021/acsmedchemlett.5b00472
Homo sapiens A549 TGI 58.3 % 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 TGI 70.4 % 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 TGI 79.5 % 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 TGI 85.4 % 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 TGI 88.9 % 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 TGI 89.1 % 10.1016/j.bmcl.2015.04.051
Homo sapiens A549 TGI 25110.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens A549 TGI 25110.0 nM 10.1021/jm061288r
Homo sapiens A549 TGI nan None 10.1016/j.bmcl.2012.09.076
Homo sapiens A549 TGI nan None 10.1016/j.bmcl.2015.04.051
Homo sapiens A549/TR Activity nan None 10.1021/acs.jmedchem.8b01424
Homo sapiens A549/TR EC50 10300.0 nM 10.1016/j.ejmech.2017.11.037
Homo sapiens A549/TR IC50 759.39 nM 10.1016/j.ejmech.2018.05.003
Homo sapiens A549/TR IC50 802.0 nM 10.1021/acs.jmedchem.1c02159
Homo sapiens A549/TR IC50 1000.0 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens A549/TR IC50 1510.0 nM 10.1016/j.ejmech.2017.03.031
Homo sapiens A549/TR IC50 1830.0 nM 10.1016/j.ejmech.2018.11.070
Homo sapiens A549/TR IC50 3112.0 nM 10.1016/j.ejmech.2018.02.062
Homo sapiens A549/TR IC50 4863.0 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens A549/TR IC50 24530.0 nM 10.1016/j.ejmech.2019.01.005
Homo sapiens A549/TR IC50 27000.0 nM 10.1021/acs.jmedchem.8b01424
Homo sapiens A549/TR IC50 28000.0 nM 10.1016/j.ejmech.2017.06.028
Homo sapiens A549/TR IC50 34300.0 nM 10.1021/acs.jmedchem.2c00077
Homo sapiens A704 IC50 1511.91 nM 10.6019/CHEMBL1201861
Homo sapiens A704 Log IC50 -5.0 nM 10.1021/jm049405a
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN Activity 65.8 % 10.1016/j.ejmech.2017.10.015
Homo sapiens ACHN Activity nan None 10.1016/j.bmc.2009.05.006
Homo sapiens ACHN GI50 158.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens ACHN GI50 158.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens ACHN GI50 398.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens ACHN GI50 398.0 nM 10.1021/jm061288r
Homo sapiens ACHN GI50 660.69 nM None
Homo sapiens ACHN IC50 25.0 nM 10.1021/jm061348t
Homo sapiens ACHN IC50 66.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens ACHN IC50 2330.0 nM 10.1016/j.bmcl.2014.10.088
Homo sapiens ACHN IC50 31500.0 nM 10.1016/j.bmc.2007.03.086
Homo sapiens ACHN IC50 31500.0 nM 10.1021/np050424c
Homo sapiens ACHN IC50 80000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens ACHN Log IC50 -5.0 nM 10.1021/jm049405a
Homo sapiens ACHN TGI 12590.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens ACHN TGI 12590.0 nM 10.1021/jm061288r
Homo sapiens ACN IC50 3.157 nM 10.6019/CHEMBL1201861
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens AGS Activity 5.92 % 10.1016/j.bmcl.2012.02.009
Homo sapiens AGS Activity 7.9 % 10.1016/j.bmcl.2012.02.009
Homo sapiens AGS Activity 70.41 % 10.1016/j.bmcl.2012.02.009
Homo sapiens AGS Activity 86.18 % 10.1016/j.bmcl.2012.02.009
Homo sapiens AGS IC50 8.0 nM 10.1021/jm500849z
Homo sapiens AGS IC50 53.0 nM 10.1021/acs.jnatprod.0c00189
Homo sapiens AGS IC50 1600.0 nM 10.1021/np3003639
Homo sapiens AGS IC50 10000.0 nM 10.1016/j.bmcl.2012.02.009
Homo sapiens AGS IC50 15400.0 nM 10.1016/j.ejmech.2012.07.047
Homo sapiens AGS IC50 15400.0 nM 10.1016/j.ejmech.2012.07.051
Homo sapiens AGS IC50 53000.0 nM 10.1021/acs.jnatprod.9b01165
Homo sapiens ALL-PO IC50 6.298 nM 10.6019/CHEMBL1201861
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Alpha-synuclein Potency 5623.4 nM None
Homo sapiens AM-38 IC50 15416.65 nM 10.6019/CHEMBL1201861
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Androgen Receptor Potency 50.1 nM None
Homo sapiens Angiotensin-converting enzyme Kd nan None 10.1021/acs.jmedchem.1c00705
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Apoptosis regulator Bcl-2 GI50 10000.0 nM 10.1021/jm060968r
Homo sapiens Apoptosis regulator Bcl-X GI50 10000.0 nM 10.1021/jm060968r
Homo sapiens ARH-77 IC50 26.01 nM 10.6019/CHEMBL1201861
Homo sapiens ARO IC50 0.2 nM 10.1021/jm0510676
Homo sapiens ARO IC50 0.2 nM 10.1021/jm070534b
Homo sapiens ASPC1 IC50 20.0 nM 10.1021/np070547s
Homo sapiens ASPC1 IC50 89.0 nM 10.1016/j.bmc.2008.10.084
Homo sapiens ASPC1 IC50 89.0 nM 10.1016/j.bmcl.2008.09.109
Homo sapiens Ataxin-2 Potency 251.2 nM None
Homo sapiens Ataxin-2 Potency 316.2 nM None
Homo sapiens Ataxin-2 Potency 7943.3 nM None
Homo sapiens Ataxin-2 Potency 31622.8 nM None
Homo sapiens Ataxin-2 Potency 44668.4 nM None
Homo sapiens ATN-1 IC50 6.09 nM 10.6019/CHEMBL1201861
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 18.3 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 29.1 nM None
Homo sapiens ATP-dependent DNA helicase Q1 Potency 15848.9 nM None
Homo sapiens BB30-HNC IC50 3.138 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 4946.17 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 25.34 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 23.44 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 6.363 nM 10.6019/CHEMBL1201861
Homo sapiens BEAS-2B IC50 7.0 nM 10.1016/j.bmc.2018.10.040
Homo sapiens BEAS-2B IC50 8.0 nM 10.1016/j.bmc.2021.116442
Homo sapiens BEAS-2B IC50 100.0 nM 10.1016/j.ejmech.2021.113685
Homo sapiens Becker IC50 7.2 nM 10.6019/CHEMBL1201861
Homo sapiens Bel-7402 Activity 1.99 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 19.73 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 21.69 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 24.42 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 33.03 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 33.23 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 43.09 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity 47.24 % 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 Activity nan None 10.1016/j.bmcl.2014.03.011
Homo sapiens Bel-7402 IC50 6.0 nM 10.1016/j.bmcl.2011.04.030
Homo sapiens Bel-7402 IC50 6.0 nM 10.1021/np3000443
Homo sapiens Bel-7402 IC50 6.0 nM 10.1021/np3008864
Homo sapiens Bel-7402 IC50 13.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens Bel-7402 IC50 60.0 nM 10.1016/j.bmcl.2010.07.085
Homo sapiens Bel-7402 IC50 95.0 nM 10.1021/np800716f
Homo sapiens Bel-7402 IC50 100.0 nM 10.1021/np0701531
Homo sapiens Bel-7402 IC50 578.2 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens Bel-7402 IC50 930.0 nM 10.1021/np070208z
Homo sapiens Bel-7402 IC50 930.0 nM 10.1021/np0704708
Homo sapiens Bel-7402 IC50 1070.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens Bel-7402 IC50 1250.0 nM 10.1016/j.bmcl.2011.11.016
Homo sapiens Bel-7402 IC50 1800.0 nM 10.1021/np1001863
Homo sapiens Bel-7402 IC50 1890.0 nM 10.1016/j.ejmech.2012.03.024
Homo sapiens Bel-7402 IC50 1890.0 nM 10.1016/j.ejmech.2012.11.002
Homo sapiens Bel-7402 IC50 1890.0 nM 10.1016/j.ejmech.2013.04.012
Homo sapiens Bel-7402 IC50 1900.0 nM 10.1021/acs.jnatprod.8b01006
Homo sapiens Bel-7402 IC50 1950.0 nM 10.1016/j.bmcl.2016.07.059
Homo sapiens Bel-7402 IC50 2000.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens Bel-7402 IC50 6300.0 nM 10.1021/np900089v
Homo sapiens Bel-7402 IC50 nan None 10.1016/j.ejmech.2010.01.051
Homo sapiens Bel-7402 IC50 nan None 10.1016/j.ejmech.2018.11.070
Homo sapiens Bel-7402 IC50 nan None 10.1016/j.ejmech.2021.113316
Homo sapiens Bel-7402 Ratio 1.0 None 10.1016/s0960-894x(00)00031-7
Homo sapiens Bel-7402 Ratio IC50 1000.0 None 10.1016/j.bmcl.2016.11.025
Homo sapiens Bel7402/5-FU IC50 10540.0 nM 10.1016/j.ejmech.2019.01.005
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens BeWo IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens BeWo IC50 7.39 ug.mL-1 10.1021/jm020119d
Homo sapiens BGC-823 Activity 15.2 % 10.1016/j.bmc.2011.05.017
Homo sapiens BGC-823 IC50 0.01 ug.mL-1 10.1016/j.bmcl.2012.08.074
Homo sapiens BGC-823 IC50 0.077 nM 10.1016/j.bmc.2020.115557
Homo sapiens BGC-823 IC50 0.4 nM 10.1021/acs.jnatprod.8b01084
Homo sapiens BGC-823 IC50 0.6 nM 10.1021/acs.jnatprod.6b00887
Homo sapiens BGC-823 IC50 0.8 nM 10.1021/acs.jnatprod.7b00014
Homo sapiens BGC-823 IC50 1.0 nM 10.1016/j.bmcl.2010.07.085
Homo sapiens BGC-823 IC50 1.0 nM 10.1016/j.bmcl.2011.04.030
Homo sapiens BGC-823 IC50 1.0 nM 10.1016/j.bmcl.2017.06.019
Homo sapiens BGC-823 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens BGC-823 IC50 1.0 nM 10.1021/np3000443
Homo sapiens BGC-823 IC50 1.0 nM 10.1021/np3008864
Homo sapiens BGC-823 IC50 1.3 nM 10.1021/acs.jnatprod.0c00189
Homo sapiens BGC-823 IC50 2.0 nM 10.1016/j.bmcl.2017.12.039
Homo sapiens BGC-823 IC50 3.29 nM 10.1021/np2004038
Homo sapiens BGC-823 IC50 3.3 nM 10.1021/np200920c
Homo sapiens BGC-823 IC50 3.3 nM 10.1021/np900302w
Homo sapiens BGC-823 IC50 3.5 nM 10.1021/np300897v
Homo sapiens BGC-823 IC50 4.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens BGC-823 IC50 7.0 nM 10.1021/np0701531
Homo sapiens BGC-823 IC50 18.9 nM 10.1016/j.bmc.2008.11.036
Homo sapiens BGC-823 IC50 20.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens BGC-823 IC50 40.0 nM 10.1021/np900089v
Homo sapiens BGC-823 IC50 1150.0 nM 10.1016/j.bmcl.2007.09.065
Homo sapiens BGC-823 IC50 1500.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens BGC-823 IC50 1500.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens BGC-823 IC50 9240.0 nM 10.1016/j.ejmech.2011.03.050
Homo sapiens BGC-823 IC50 9260.0 nM 10.1016/j.ejmech.2016.10.012
Homo sapiens BGC-823 IC50 33090.0 nM 10.1016/j.bmc.2011.05.017
Homo sapiens Bile salt export pump AC50 9200.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 15000.0 nM 10.1002/hep.27206
Homo sapiens Bile salt export pump IC50 15000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 24400.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 26800.0 nM 10.1023/a:1023278211849
Homo sapiens Bile salt export pump IC50 28900.0 nM 10.1023/a:1023278211849
Homo sapiens BL-41 IC50 9.345 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 9.303 nM 10.6019/CHEMBL1201861
Homo sapiens Bloom syndrome protein Potency 17782.8 nM None
Homo sapiens BOKU IC50 125.79 nM 10.6019/CHEMBL1201861
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Breast carcinoma cell IC50 7800.0 nM 10.1016/j.ejmech.2019.02.047
Homo sapiens Breast carcinoma cell TGI nan None 10.1016/j.bmcl.2018.01.053
Homo sapiens Bromodomain-containing protein 4 Delta TM -0.05 C 10.6019/CHEMBL5308504
Homo sapiens BT-20 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens BT-20 Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens BT-474 Activity 10.0 % 10.1021/acs.jnatprod.8b00964
Homo sapiens BT-474 IC50 8.36 nM 10.1021/np500342m
Homo sapiens BT-474 IC50 208.92 nM 10.6019/CHEMBL1201861
Homo sapiens BT-549 Activity nan None 10.1016/j.bmcl.2018.01.053
Homo sapiens BT-549 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens BT-549 GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens BT-549 GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens BT-549 GI50 6.31 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens BT-549 GI50 32.66 nM None
Homo sapiens BT-549 IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens BT-549 IC50 6.0 nM 10.1021/jm200436t
Homo sapiens BT-549 IC50 20.0 nM 10.1016/j.bmc.2009.10.019
Homo sapiens BV-173 IC50 25.54 nM 10.6019/CHEMBL1201861
Homo sapiens BXPC-3 IC50 90.0 nM 10.1021/np3003639
Homo sapiens BXPC-3 Imax 42.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens BXPC-3 LC50 500.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens BXPC-3 Log IC50 -8.6 nM 10.1021/jm049405a
Homo sapiens C2BBe1 IC50 267.47 nM 10.6019/CHEMBL1201861
Homo sapiens C32 Activity nan None 10.1016/j.bmc.2009.05.006
Homo sapiens C8166 IC50 22274.64 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 1732.16 nM 10.6019/CHEMBL1201861
Homo sapiens Ca9-22 IC50 100000.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens Caco-2 Activity 2.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens Caco-2 Activity 20.0 % 10.1016/j.ejmech.2022.114231
Homo sapiens Caco-2 Activity 52.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens Caco-2 Activity 60.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens Caco-2 Activity nan None 10.1007/s00044-012-0424-0
Homo sapiens Caco-2 Activity nan None 10.1016/j.bmc.2009.05.006
Homo sapiens Caco-2 IC50 0.007 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens Caco-2 IC50 0.0078 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens Caco-2 IC50 8.0 nM 10.1016/j.bmcl.2008.06.039
Homo sapiens Caco-2 IC50 8.0 nM 10.1016/j.ejmech.2013.03.029
Homo sapiens Caco-2 IC50 14.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens Caco-2 IC50 14.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens Caco-2 IC50 20.0 nM 10.1016/j.bmc.2009.07.051
Homo sapiens Caco-2 IC50 20.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens Caco-2 IC50 310.0 nM 10.1016/j.ejmech.2014.05.084
Homo sapiens Caco-2 IC50 2800.0 nM 10.1039/C6MD00256K
Homo sapiens Caco-2 IC50 nan None 10.1007/s00044-012-0424-0
Homo sapiens Caco-2 IC90 0.065 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens Caco-2 IC90 0.065 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens Caco-2 Papp 0.97 ucm/s 10.1016/j.bmc.2013.11.037
Homo sapiens Caco-2 Papp 6.6 10'-5 cm/s 10.1016/j.bmcl.2011.06.034
Homo sapiens Caco-2 Papp 33.39 ucm/s 10.1016/j.bmc.2013.11.037
Homo sapiens Caco-2 Papp 50.3 10'-5 cm/s 10.1016/j.bmcl.2011.06.034
Homo sapiens Caco-2 Ratio 7.62 None 10.1016/j.bmcl.2011.06.034
Homo sapiens Caco-2 Ratio 34.38 None 10.1016/j.bmc.2013.11.037
Homo sapiens CAKI-1 Effective dose nan None 10.1021/jm020548b
Homo sapiens CAKI-1 GI50 158.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens CAKI-1 GI50 158.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens CAKI-1 GI50 203.24 nM None
Homo sapiens CAKI-2 Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens CAL-148 IC50 54.39 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-27 GI 22.0 % None
Homo sapiens CAL-27 GI 44.0 % None
Homo sapiens CAL-27 GI 53.0 % None
Homo sapiens CAL-27 GI 61.0 % None
Homo sapiens CAL-27 GI 66.0 % None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Calu-6 IC50 10.12 nM 10.6019/CHEMBL1201861
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens CAPAN-1 IC50 3.3 nM 10.1016/j.bmcl.2018.12.004
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens CAS-1 IC50 270.96 nM 10.6019/CHEMBL1201861
Homo sapiens Casein kinase I delta Delta TM -0.22 C 10.6019/CHEMBL5308504
Homo sapiens Ca-Ski IC50 2900.0 nM 10.1016/j.ejmech.2018.01.020
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCD 19Lu IC50 2.0 ug.mL-1 10.1016/S0960-894X(97)00071-1
Homo sapiens CCRF-CEM Activity nan None 10.1016/j.ejmech.2008.07.016
Homo sapiens CCRF-CEM GI50 2.667 nM None
Homo sapiens CCRF-CEM GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens CCRF-CEM GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens CCRF-CEM IC50 0.001 ug.mL-1 10.1016/S0960-894X(97)00071-1
Homo sapiens CCRF-CEM IC50 0.27 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens CCRF-CEM IC50 0.27 nM 10.1021/jm200488a
Homo sapiens CCRF-CEM IC50 1.1 nM 10.1016/j.ejmech.2008.07.016
Homo sapiens CCRF-CEM IC50 1.1 nM 10.1021/jm060197r
Homo sapiens CCRF-CEM IC50 1.2 nM 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM IC50 1.2 nM 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM IC50 1.274 nM 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM IC50 1.3 nM 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM IC50 1.5 nM 10.1016/j.bmcl.2004.06.080
Homo sapiens CCRF-CEM IC50 2.0 nM 10.1021/jm900476c
Homo sapiens CCRF-CEM IC50 3.0 nM 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM IC50 3.0 nM 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM IC50 3.0 nM 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM IC50 3.1 nM 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM IC50 3.1 nM 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM IC50 4.0 nM 10.1016/j.ejmech.2019.111584
Homo sapiens CCRF-CEM IC50 8.708 nM 10.6019/CHEMBL1201861
Homo sapiens CCRF-CEM IC50 400.0 nM 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM IC50 429.0 nM 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM IC50 429.0 nM 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM IC50 429.0 nM 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM IC50 430.0 nM 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM IC50 430.0 nM 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM IC50 430.0 nM 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM IC50 430.0 nM 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM IC50 484.3 nM 10.1021/jm060197r
Homo sapiens CCRF-CEM IC50 1200.0 nM 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM IC50 1270.0 nM 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM IC50 1270.0 nM 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM IC50 1270.0 nM 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM IC50 1270.0 nM 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM IC50 1274.0 nM 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM IC50 1274.0 nM 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM IC50 1731.0 nM 10.1021/jm060197r
Homo sapiens CCRF-CEM IC50 nan None 10.1016/j.ejmech.2011.10.013
Homo sapiens CCRF-CEM IC50 nan None 10.1021/jm200392p
Homo sapiens CCRF-CEM Imax 95.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens CCRF-CEM LC50 3.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens CCRF-CEM Ratio IC50 143.0 None 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM Ratio IC50 266.0 None 10.1021/jm200764t
Homo sapiens CCRF-CEM Ratio IC50 330.0 None 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM Ratio IC50 330.0 None 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM Ratio IC50 330.0 None 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM Ratio IC50 330.0 None 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM Ratio IC50 330.0 None 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM Ratio IC50 333.0 None 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM Ratio IC50 358.0 None 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM Ratio IC50 423.0 None 10.1016/j.bmc.2011.01.055
Homo sapiens CCRF-CEM Ratio IC50 980.0 None 10.1016/j.bmc.2008.04.024
Homo sapiens CCRF-CEM Ratio IC50 980.0 None 10.1016/j.bmc.2008.12.022
Homo sapiens CCRF-CEM Ratio IC50 980.0 None 10.1016/j.bmc.2010.01.061
Homo sapiens CCRF-CEM Ratio IC50 980.0 None 10.1016/j.bmc.2010.11.005
Homo sapiens CCRF-CEM Ratio IC50 980.0 None 10.1016/j.bmc.2010.11.030
Homo sapiens CCRF-CEM Ratio IC50 980.0 None 10.1016/j.ejmech.2012.03.030
Homo sapiens CCRF-CEM Ratio IC50 1000.0 None 10.1016/j.bmc.2009.06.018
Homo sapiens CCRF-CEM Ratio IC50 12370.0 None 10.1016/j.ejmech.2011.08.034
Homo sapiens Cellular tumor antigen p53 Activity nan None 10.1016/j.ejmech.2011.05.046
Homo sapiens Cellular tumor antigen p53 Potency 7943.3 nM None
Homo sapiens CEM-VLB Ratio IC50 12370.0 None 10.1021/jm200488a
Homo sapiens CESS IC50 7.374 nM 10.6019/CHEMBL1201861
Homo sapiens CFPAC-1 IC50 47.0 nM 10.1016/j.bmc.2010.07.069
Homo sapiens CFPAC-1 Log IC50 -8.3 nM 10.1021/jm049405a
Homo sapiens CGTH-W-1 IC50 54.49 nM 10.6019/CHEMBL1201861
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 11380.0 nM None
Homo sapiens Cholecystokinin A receptor Ki 2276.0 nM None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens CHP-126 IC50 2247.37 nM 10.6019/CHEMBL1201861
Homo sapiens Chromobox protein homolog 1 Potency 89125.1 nM None
Homo sapiens CMK IC50 27.34 nM 10.6019/CHEMBL1201861
Homo sapiens Col2 ED50 46.0 nM 10.1021/np0304417
Homo sapiens Col2 IC50 20.0 nM 10.1021/np010322w
Homo sapiens COLO 205 GI 9.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens COLO 205 GI 57.0 % 10.1007/s00044-012-0404-4
Homo sapiens COLO 205 GI 61.0 % 10.1016/j.ejmech.2009.10.042
Homo sapiens COLO 205 GI 67.0 % 10.1007/s00044-012-0106-y
Homo sapiens COLO 205 GI nan None 10.1007/s00044-012-0312-7
Homo sapiens COLO 205 GI50 1.76 nM 10.1021/np50103a016
Homo sapiens COLO 205 GI50 3.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens COLO 205 GI50 3.0 nM 10.1021/jm061288r
Homo sapiens COLO 205 GI50 3.034 nM None
Homo sapiens COLO 205 GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens COLO 205 GI50 7.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens COLO 205 GI50 7.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens COLO 205 IC50 3.0 nM 10.1016/j.bmcl.2014.07.035
Homo sapiens COLO 205 IC50 3.3 nM 10.1016/j.bmc.2008.11.016
Homo sapiens COLO 205 IC50 3.3 nM 10.1016/j.bmcl.2007.03.070
Homo sapiens COLO 205 IC50 3.3 nM 10.1021/jm060717i
Homo sapiens COLO 205 IC50 3.31 nM 10.1021/ml1003074
Homo sapiens COLO 205 IC50 5.0 nM 10.1021/jm200436t
Homo sapiens COLO 205 LC50 145.0 nM 10.1021/np50103a016
Homo sapiens COLO 205 TGI 43.2 nM 10.1021/np50103a016
Homo sapiens COLO 205 TGI 316.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens COLO 205 TGI 316.0 nM 10.1021/jm061288r
Homo sapiens COLO 320DM IC50 0.0045 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens COLO 320DM IC90 0.01 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens COLO-320-HSR IC50 195.32 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 236.75 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 29.08 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 8478.7 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 5083.13 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 5498.84 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L23 Activity nan None 10.1016/j.bmc.2009.05.006
Homo sapiens COR-L279 IC50 9.99 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 59.27 nM 10.6019/CHEMBL1201861
Homo sapiens Coronary artery smooth muscle cell line IC50 1000.0 nM 10.1021/jm0304111
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens CP66-MEL IC50 951.98 nM 10.6019/CHEMBL1201861
Homo sapiens CP67-MEL IC50 68.1 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 30.79 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 78.1 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 14.78 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 21134.86 nM 10.6019/CHEMBL1201861
Homo sapiens CWR22R CC50 3.9 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens CWR22R IC50 80.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens CWR22R IC50 80.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens CWR22R IC50 80.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens CWR22R TGI 30.0 % 10.1016/j.bmcl.2019.06.035
Homo sapiens Cyclin-dependent kinase 2 Delta TM 0.99 C 10.6019/CHEMBL5308504
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 AC50 31622.78 nM None
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C8 Activity nan None None
Homo sapiens Cytochrome P450 2C8 Inhibition 80.89 % 10.1021/acs.jmedchem.0c00456
Homo sapiens Cytochrome P450 2C9 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 AC50 1258.93 nM None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None 10.1021/acs.jmedchem.1c00404
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Log 1/Km -1.255 None 10.1016/j.bmcl.2005.06.015
Homo sapiens Cytochrome P450 3A4 Potency 1258.9 nM None
Homo sapiens D-247MG IC50 599.24 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 117.12 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 10495.93 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 112.44 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 2868.05 nM 10.6019/CHEMBL1201861
Homo sapiens Daoy IC50 2.0 nM 10.1016/j.bmcl.2017.12.039
Homo sapiens Daudi IC50 17.08 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 828.72 nM 10.6019/CHEMBL1201861
Homo sapiens DEL IC50 8.449 nM 10.6019/CHEMBL1201861
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 4202.0 nM None
Homo sapiens Delta opioid receptor Ki 1481.0 nM None
Homo sapiens DG-75 Activity nan None 10.1016/j.bmcl.2013.01.020
Homo sapiens DG-75 IC50 10.0 nM 10.1016/j.bmc.2010.11.054
Homo sapiens DG-75 IC50 10.0 nM 10.1016/j.ejmech.2009.07.027
Homo sapiens DG-75 IC50 68.99 nM 10.6019/CHEMBL1201861
Homo sapiens DJM-1 IC50 5.301 nM 10.6019/CHEMBL1201861
Homo sapiens DLD-1 Activity 0.5 % 10.1021/np070477p
Homo sapiens DLD-1 Activity 6.2 day 10.1021/np070477p
Homo sapiens DLD-1 Activity 6.5 % 10.1021/np070477p
Homo sapiens DLD-1 Activity 8.0 day 10.1021/jm800086e
Homo sapiens DLD-1 Activity 8.0 day 10.1021/np8006556
Homo sapiens DLD-1 Activity 8.1 % 10.1021/np070477p
Homo sapiens DLD-1 Activity nan None 10.1021/jm800086e
Homo sapiens DLD-1 Activity nan None 10.1021/np070477p
Homo sapiens DLD-1 Activity nan None 10.1021/np8006556
Homo sapiens DLD-1 EC50 54.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens DLD-1 EC50 75.0 nM 10.1021/jm049640t
Homo sapiens DLD-1 GI50 10.0 nM 10.1016/j.bmcl.2008.11.067
Homo sapiens DLD-1 GI50 10.0 nM 10.1016/j.bmcl.2010.05.074
Homo sapiens DLD-1 GI50 10.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens DLD-1 GI50 44.77 nM None
Homo sapiens DLD-1 IC30 23.0 uM 10.1021/np200241c
Homo sapiens DLD-1 IC50 11.0 nM 10.1021/np070547s
Homo sapiens DLD-1 IC50 22.0 nM 10.1016/j.bmc.2008.10.084
Homo sapiens DLD-1 IC50 22.0 nM 10.1016/j.bmcl.2008.09.109
Homo sapiens DLD-1 IC50 27.0 nM 10.1016/s0960-894x(00)00150-5
Homo sapiens DLD-1 IC50 50.0 nM 10.1021/jm200436t
Homo sapiens DLD-1 IC50 90.0 nM 10.1016/j.bmcl.2006.06.007
Homo sapiens DLD-1 IC50 39000.0 nM 10.1021/np200241c
Homo sapiens DLD-1 IC50 nan None 10.1016/j.bmcl.2011.01.097
Homo sapiens DLD-1 IC50 nan None 10.1016/j.bmcl.2011.01.111
Homo sapiens DLD-1 Log IC50 -7.5 nM 10.1021/jm049405a
Homo sapiens DLKP cell line Combination_index 1.227 None 10.1016/j.bmcl.2003.12.015
Homo sapiens DLKP cell line Combination_index 1.233 None 10.1016/j.bmcl.2003.12.015
Homo sapiens DLKP cell line Inhibition nan % 10.1016/j.bmcl.2003.12.015
Homo sapiens DMS-114 GI50 2.904 nM None
Homo sapiens DMS-114 GI50 12.3 nM 10.1021/np50103a016
Homo sapiens DMS-114 IC50 25.02 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-114 LC50 1000.0 nM 10.1021/np50103a016
Homo sapiens DMS-114 TGI 61.2 nM 10.1021/np50103a016
Homo sapiens DMS-153 IC50 1101.24 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-273 GI50 3.126 nM None
Homo sapiens DMS-79 IC50 2276.44 nM 10.6019/CHEMBL1201861
Homo sapiens DOHH-2 IC50 12.03 nM 10.6019/CHEMBL1201861
Homo sapiens Dopamine D1 receptor AC50 2160.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens DSH1 IC50 3234.42 nM 10.6019/CHEMBL1201861
Homo sapiens DU-145 Activity 18.9 % 10.1021/np200563x
Homo sapiens DU-145 Activity nan None 10.1016/j.bmcl.2009.07.089
Homo sapiens DU-145 EC50 0.005 ug.mL-1 10.1016/j.bmcl.2008.06.099
Homo sapiens DU-145 EC50 0.005 ug.mL-1 10.1021/np800622a
Homo sapiens DU-145 EC50 5.9 nM 10.1016/j.bmcl.2011.11.026
Homo sapiens DU-145 ED50 0.003 uM 10.1021/np100406d
Homo sapiens DU-145 ED50 1.3 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens DU-145 GI 42.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens DU-145 GI 52.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens DU-145 GI 90.62 % 10.1016/j.bmc.2013.11.037
Homo sapiens DU-145 GI50 1.47 nM 10.1021/acs.jmedchem.9b00551
Homo sapiens DU-145 GI50 1.52 nM 10.1039/C9MD00127A
Homo sapiens DU-145 GI50 2.5 nM None
Homo sapiens DU-145 GI50 2.55 nM 10.1016/j.bmcl.2012.08.014
Homo sapiens DU-145 GI50 3.86 nM 10.1016/j.ejmech.2011.12.025
Homo sapiens DU-145 GI50 5.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens DU-145 GI50 5.0 nM 10.1021/jm061288r
Homo sapiens DU-145 GI50 5.23 nM 10.1016/j.bmc.2011.02.004
Homo sapiens DU-145 GI50 5.55 nM 10.1016/j.bmc.2011.01.034
Homo sapiens DU-145 GI50 5.568 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens DU-145 GI50 5.7 nM 10.1016/j.bmcl.2015.02.018
Homo sapiens DU-145 GI50 6.0 nM 10.1016/j.bmc.2013.11.018
Homo sapiens DU-145 GI50 6.0 nM 10.1016/j.bmc.2015.07.016
Homo sapiens DU-145 GI50 6.0 nM 10.1016/j.ejmech.2013.06.041
Homo sapiens DU-145 GI50 6.0 nM 10.1021/jm4016526
Homo sapiens DU-145 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens DU-145 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens DU-145 GI50 6.5 nM 10.1016/j.bmc.2012.11.047
Homo sapiens DU-145 GI50 16.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens DU-145 GI50 23.93 nM None
Homo sapiens DU-145 GI50 32.0 nM 10.1021/jm400479p
Homo sapiens DU-145 IC50 0.002 ug.mL-1 10.1021/np900620y
Homo sapiens DU-145 IC50 0.0024 ug.mL-1 10.1016/j.bmcl.2012.04.084
Homo sapiens DU-145 IC50 0.0037 ug.mL-1 10.1016/j.bmcl.2011.12.024
Homo sapiens DU-145 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens DU-145 IC50 1.0 nM 10.1021/acs.jnatprod.9b00340
Homo sapiens DU-145 IC50 1.1 nM 10.1021/acs.jmedchem.7b01858
Homo sapiens DU-145 IC50 1.15 nM 10.1021/acs.jmedchem.9b00706
Homo sapiens DU-145 IC50 1.3 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens DU-145 IC50 1.3 nM 10.1021/jm200488a
Homo sapiens DU-145 IC50 1.5 nM 10.1021/acs.jmedchem.8b00827
Homo sapiens DU-145 IC50 1.5 nM 10.1021/acs.jmedchem.9b01815
Homo sapiens DU-145 IC50 2.3 nM 10.1016/j.bmc.2011.06.084
Homo sapiens DU-145 IC50 2.3 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens DU-145 IC50 2.35 nM 10.1016/j.bmcl.2009.12.041
Homo sapiens DU-145 IC50 2.7 nM 10.1021/jm049208b
Homo sapiens DU-145 IC50 3.4 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens DU-145 IC50 4.0 nM 10.1021/acs.jnatprod.9b00140
Homo sapiens DU-145 IC50 4.0 nM 10.1021/np500768s
Homo sapiens DU-145 IC50 4.88 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens DU-145 IC50 4.89 nM 10.1021/jm010974h
Homo sapiens DU-145 IC50 5.0 nM 10.1016/j.bmcl.2006.07.020
Homo sapiens DU-145 IC50 5.0 nM 10.1016/j.bmcl.2008.02.029
Homo sapiens DU-145 IC50 5.0 nM 10.1016/j.bmcl.2013.07.032
Homo sapiens DU-145 IC50 10.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens DU-145 IC50 30.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens DU-145 IC50 40.0 nM 10.1021/np400212d
Homo sapiens DU-145 IC50 1500.0 nM 10.1021/np500382k
Homo sapiens DU-145 IC50 1790.0 nM 10.1021/np5004559
Homo sapiens DU-145 IC50 3000.0 nM 10.1016/j.bmc.2011.06.084
Homo sapiens DU-145 IC50 3100.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens DU-145 IC50 4840.0 nM 10.1021/np900225p
Homo sapiens DU-145 IC50 8626.0 nM 10.1016/j.bmcl.2011.06.036
Homo sapiens DU-145 IC50 17200.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens DU-145 Inhibition 53.0 % 10.1016/j.bmcl.2007.10.011
Homo sapiens DU-145 Log IC50 -8.8 nM 10.1021/jm049405a
Homo sapiens DU-145 Ratio IC50 1.4 None 10.1021/acs.jnatprod.5b00908
Homo sapiens DU-145 Ratio IC50 1300.0 None 10.1016/j.bmc.2011.06.084
Homo sapiens DU-145 Survival 11.6 % 10.1016/s0960-894x(02)00217-2
Homo sapiens DU-145 Survival 12.1 % 10.1016/s0960-894x(02)00217-2
Homo sapiens DU-145 Survival 43.3 % 10.1016/s0960-894x(02)00217-2
Homo sapiens DU-145 Survival 46.0 % 10.1016/s0960-894x(02)00217-2
Homo sapiens DU-145 TGI 26.6 % 10.1021/jm3013008
Homo sapiens DU-145 TGI 47.0 % 10.1021/acs.jmedchem.1c00966
Homo sapiens DU-145 TGI 794.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens DU-145 TGI 794.0 nM 10.1021/jm061288r
Homo sapiens DU-4475 IC50 42.44 nM 10.6019/CHEMBL1201861
Homo sapiens EB2 IC50 9198.35 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 299.79 nM 10.6019/CHEMBL1201861
Homo sapiens ECa-109 cell line Activity 0.5 % 10.1016/j.bmcl.2017.02.008
Homo sapiens ECa-109 cell line Activity 0.9 % 10.1016/j.bmcl.2017.02.008
Homo sapiens ECa-109 cell line Activity 4.5 % 10.1016/j.bmcl.2017.02.008
Homo sapiens ECa-109 cell line Activity 94.1 % 10.1016/j.bmcl.2017.02.008
Homo sapiens ECa-109 cell line Activity nan None 10.1016/j.bmcl.2017.02.008
Homo sapiens ECa-109 cell line IC50 1200.0 nM 10.1021/acs.jnatprod.8b01006
Homo sapiens ECa-109 cell line Ratio 1.0 None 10.1016/s0960-894x(00)00031-7
Homo sapiens ECC4 IC50 1549.49 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 72.57 nM 10.6019/CHEMBL1201861
Homo sapiens EHEB IC50 390.85 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX GI50 79.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens EKVX GI50 79.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens EKVX GI50 127.94 nM None
Homo sapiens EKVX IC50 7168.65 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX IC50 150000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens EM-2 IC50 157.06 nM 10.6019/CHEMBL1201861
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 2511.9 nM None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens EOL1 IC50 26.88 nM 10.6019/CHEMBL1201861
Homo sapiens Epidermal growth factor receptor erbB1 IC50 10000.0 nM 10.1021/jm500034j
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens ES1 IC50 12.88 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 9306.65 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 4.494 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 7866.62 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 95.89 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 15249.4 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 5.38 nM 10.6019/CHEMBL1201861
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor alpha Potency 19952.6 nM None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens ETK-1 IC50 1.521 nM 10.6019/CHEMBL1201861
Homo sapiens EVSA-T IC50 0.003 ug.mL-1 10.1016/j.bmc.2007.03.041
Homo sapiens EVSA-T IC50 0.003 ug.mL-1 10.1021/jm0009078
Homo sapiens EVSA-T IC50 39.23 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 3.714 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 11669.4 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 28070.19 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 10333.33 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 6.937 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 7036.75 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 64.83 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 109.8 nM 10.6019/CHEMBL1201861
Homo sapiens FaDu Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens Fibroblast Activity 30.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens Fibroblast Growth Rate -1.0 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.99 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.7 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.67 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.64 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.57 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.54 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.39 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast Growth Rate -0.34 None 10.6019/CHEMBL5303304
Homo sapiens Fibroblast IC50 1.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens Fibroblast IC50 100.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens Fibroblast IC50 250.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens Fibroblast growth factor receptor 1 IC50 10000.0 nM 10.1021/jm500034j
Homo sapiens Fibroblast growth factor receptor 3 Delta TM 0.44 C 10.6019/CHEMBL5308504
Homo sapiens GAK IC50 101.6 nM 10.6019/CHEMBL1201861
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GB-1 IC50 36.0 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 149.01 nM 10.6019/CHEMBL1201861
Homo sapiens GDM-1 IC50 219.71 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 5.2 nM None
Homo sapiens Geminin Potency 9.2 nM None
Homo sapiens Geminin Potency 21.1 nM None
Homo sapiens Geminin Potency 22.4 nM None
Homo sapiens Geminin Potency 53.4 nM None
Homo sapiens Geminin Potency 58.0 nM None
Homo sapiens Geminin Potency 65.1 nM None
Homo sapiens Geminin Potency 168.9 nM None
Homo sapiens Geminin Potency 2592.9 nM None
Homo sapiens Geminin Potency 5956.9 nM None
Homo sapiens GES1 IC50 7.9 nM 10.1021/acs.jnatprod.0c00189
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens GI-1 IC50 13.73 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 84.52 nM 10.6019/CHEMBL1201861
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glucocorticoid receptor Potency 141.3 nM None
Homo sapiens Glycogen synthase kinase-3 beta Delta TM -0.02 C 10.6019/CHEMBL5308504
Homo sapiens GOTO IC50 278.94 nM 10.6019/CHEMBL1201861
Homo sapiens GR-ST IC50 56.21 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 4.339 nM 10.6019/CHEMBL1201861
Homo sapiens H4 Log IC50 -6.6 nM 10.1021/jm049405a
Homo sapiens H69AR IC50 2.5 nM 10.1021/jm061348t
Homo sapiens HaCaT Activity 70.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens HaCaT IC50 2.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens HaCaT IC50 24.0 nM 10.1021/np200431k
Homo sapiens HaCaT IC50 24.0 nM 10.1021/np5009569
Homo sapiens HAL-01 IC50 5731.85 nM 10.6019/CHEMBL1201861
Homo sapiens HBL-100 GI50 0.017 nM 10.1016/j.bmcl.2011.09.069
Homo sapiens HC-1 IC50 7.213 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1143 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens HCC1187 IC50 19.24 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1599 IC50 20.2 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1806 Activity 66.0 % 10.1021/acs.jmedchem.0c00408
Homo sapiens HCC1806 Activity nan None 10.1021/acs.jmedchem.0c00408
Homo sapiens HCC1806 IC50 1.0 nM 10.1016/j.bmc.2018.10.040
Homo sapiens HCC1806 IC50 8.0 nM 10.1016/j.bmc.2021.116442
Homo sapiens HCC1806 IC50 9.0 nM 10.1016/j.bmc.2021.116442
Homo sapiens HCC1937 IC50 10000.0 nM 10.1016/j.bmcl.2015.03.081
Homo sapiens HCC1937 Inhibition 0.0 % 10.1016/j.bmcl.2015.03.081
Homo sapiens HCC2157 IC50 339.13 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 159.8 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 GI50 1.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HCC 2998 GI50 1.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HCC 2998 GI50 3.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens HCC 2998 GI50 3.0 nM 10.1021/jm061288r
Homo sapiens HCC 2998 GI50 3.412 nM None
Homo sapiens HCC 2998 GI50 3.981 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens HCC 2998 TGI 126.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens HCC 2998 TGI 126.0 nM 10.1021/jm061288r
Homo sapiens HCE-4 IC50 7.671 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 20.92 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 Activity 9.2 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 Activity 9.4 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 Activity 13.83 % 10.1016/j.bmcl.2019.126851
Homo sapiens HCT-116 Activity 14.1 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 Activity 25.09 % 10.1016/j.bmcl.2019.126851
Homo sapiens HCT-116 Activity 44.0 % 10.1016/j.ejmech.2014.03.021
Homo sapiens HCT-116 Activity 61.69 % 10.1016/j.bmcl.2019.126851
Homo sapiens HCT-116 Activity 67.3 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 Activity 72.0 % 10.1021/np3006666
Homo sapiens HCT-116 Activity 90.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmc.2019.02.046
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmcl.2015.11.027
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmcl.2019.05.041
Homo sapiens HCT-116 Activity nan None 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 Activity nan None 10.1039/C4MD00387J
Homo sapiens HCT-116 EC50 18.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens HCT-116 EC50 18.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens HCT-116 EC50 23.0 nM 10.1016/j.bmc.2009.02.029
Homo sapiens HCT-116 EC50 24.0 nM 10.1021/jm7010657
Homo sapiens HCT-116 FC 3.0 None 10.1016/j.bmcl.2014.11.055
Homo sapiens HCT-116 GI50 0.1279 ug.mL-1 10.1016/j.bmcl.2017.01.004
Homo sapiens HCT-116 GI50 1.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens HCT-116 GI50 2.679 nM None
Homo sapiens HCT-116 GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HCT-116 GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HCT-116 GI50 5.0 nM None
Homo sapiens HCT-116 GI50 10.0 nM 10.1021/jm400479p
Homo sapiens HCT-116 GI50 60.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens HCT-116 GI50 60.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens HCT-116 GI50 6690000.0 nM 10.1039/C6MD00278A
Homo sapiens HCT-116 GI90 5.715 ug ml-1 10.1016/j.bmcl.2017.01.004
Homo sapiens HCT-116 IC50 0.00011 nM 10.1016/j.ejmech.2019.111665
Homo sapiens HCT-116 IC50 0.008 ug.mL-1 10.1021/np0703186
Homo sapiens HCT-116 IC50 0.02 ug.mL-1 10.1021/np50078a018
Homo sapiens HCT-116 IC50 0.045 ug.mL-1 10.1021/np400110g
Homo sapiens HCT-116 IC50 0.2 nM 10.1021/acs.jnatprod.6b00887
Homo sapiens HCT-116 IC50 0.206 nM 10.1016/j.bmc.2020.115557
Homo sapiens HCT-116 IC50 0.6 nM 10.1016/j.bmcl.2006.11.008
Homo sapiens HCT-116 IC50 0.8 nM 10.1016/j.bmc.2009.07.051
Homo sapiens HCT-116 IC50 0.915 ug.mL-1 10.1016/j.ejmech.2020.112609
Homo sapiens HCT-116 IC50 1.0 nM 10.1016/0960-894X(95)00453-Z
Homo sapiens HCT-116 IC50 1.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens HCT-116 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens HCT-116 IC50 1.0 nM 10.1021/jm900476c
Homo sapiens HCT-116 IC50 1.1 nM 10.1016/j.bmc.2008.12.022
Homo sapiens HCT-116 IC50 1.1 nM 10.1016/j.bmc.2009.06.018
Homo sapiens HCT-116 IC50 1.1 nM 10.1021/np800559z
Homo sapiens HCT-116 IC50 1.3 nM 10.1016/j.bmc.2008.04.024
Homo sapiens HCT-116 IC50 1.3 nM 10.1016/j.bmc.2010.01.061
Homo sapiens HCT-116 IC50 1.3 nM 10.1016/j.bmc.2010.11.030
Homo sapiens HCT-116 IC50 1.5 nM 10.1021/jm060197r
Homo sapiens HCT-116 IC50 1.6 nM 10.1016/s0960-894x(00)00242-0
Homo sapiens HCT-116 IC50 1.8 nM 10.1021/acs.jnatprod.8b01084
Homo sapiens HCT-116 IC50 2.0 nM 10.1016/0960-894X(94)80020-0
Homo sapiens HCT-116 IC50 2.0 nM 10.1016/j.bmc.2010.09.028
Homo sapiens HCT-116 IC50 2.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens HCT-116 IC50 2.0 nM 10.1016/S0960-894X(97)10142-1
Homo sapiens HCT-116 IC50 2.3 nM 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 IC50 2.399 nM 10.1016/j.ejmech.2009.12.054
Homo sapiens HCT-116 IC50 2.4 nM 10.1016/0960-894X(95)00453-Z
Homo sapiens HCT-116 IC50 2.4 nM 10.1021/jm00012a029
Homo sapiens HCT-116 IC50 2.4 nM 10.1021/jm050996u
Homo sapiens HCT-116 IC50 2.6 nM 10.1016/j.bmcl.2004.06.080
Homo sapiens HCT-116 IC50 2.61 nM 10.1016/j.bmc.2019.02.046
Homo sapiens HCT-116 IC50 2.9 ug.mL-1 10.1039/d2md00192f
Homo sapiens HCT-116 IC50 3.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens HCT-116 IC50 3.21 nM 10.1021/np100153m
Homo sapiens HCT-116 IC50 3.5 nM 10.1021/np900126r
Homo sapiens HCT-116 IC50 3.8 nM 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/S0960-894X(00)80075-X
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/s0960-894x(01)00066-x
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/s0960-894x(01)00067-1
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/S0960-894X(01)80385-1
Homo sapiens HCT-116 IC50 4.0 nM 10.1016/S0960-894X(01)80980-X
Homo sapiens HCT-116 IC50 4.0 nM 10.1021/jm3013097
Homo sapiens HCT-116 IC50 4.1 nM 10.1016/j.bmcl.2018.02.006
Homo sapiens HCT-116 IC50 4.1 nM 10.1021/acs.jmedchem.7b00958
Homo sapiens HCT-116 IC50 5.0 nM 10.1016/j.ejmech.2022.114112
Homo sapiens HCT-116 IC50 6.0 nM 10.1021/acs.jnatprod.0c00064
Homo sapiens HCT-116 IC50 6.13 nM 10.1016/j.bmcl.2013.04.081
Homo sapiens HCT-116 IC50 7.48 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens HCT-116 IC50 13.6 nM 10.1016/j.bmcl.2008.06.066
Homo sapiens HCT-116 IC50 14.0 nM 10.1016/j.bmc.2017.09.019
Homo sapiens HCT-116 IC50 20.0 nM 10.1016/j.bmcl.2018.01.036
Homo sapiens HCT-116 IC50 20.0 nM 10.1016/j.ejmech.2020.112519
Homo sapiens HCT-116 IC50 20.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens HCT-116 IC50 21.0 nM 10.1016/j.ejmech.2021.113629
Homo sapiens HCT-116 IC50 30.0 nM 10.1016/j.bmcl.2017.06.019
Homo sapiens HCT-116 IC50 30.0 nM 10.1021/acs.jnatprod.0c00919
Homo sapiens HCT-116 IC50 33.8 nM 10.1021/acs.jnatprod.7b01012
Homo sapiens HCT-116 IC50 35.0 nM 10.1021/jm0102607
Homo sapiens HCT-116 IC50 38.0 nM 10.1016/j.bmcl.2017.12.039
Homo sapiens HCT-116 IC50 50.0 nM 10.1021/np3002173
Homo sapiens HCT-116 IC50 61.0 nM 10.1021/jm8006257
Homo sapiens HCT-116 IC50 62.9 nM 10.1021/acs.jmedchem.2c01595
Homo sapiens HCT-116 IC50 69.0 nM 10.1016/j.ejmech.2014.06.002
Homo sapiens HCT-116 IC50 1370.0 nM 10.1016/j.ejmech.2017.11.023
Homo sapiens HCT-116 IC50 1550.0 nM 10.1016/j.bmcl.2014.10.088
Homo sapiens HCT-116 IC50 2202.0 nM 10.1021/acs.jmedchem.1c01123
Homo sapiens HCT-116 IC50 3300.0 nM 10.1021/acs.jnatprod.6b00561
Homo sapiens HCT-116 IC50 4370.0 nM 10.1016/j.bmc.2009.03.037
Homo sapiens HCT-116 IC50 4370.0 nM 10.1016/j.bmc.2010.10.047
Homo sapiens HCT-116 IC50 4370.0 nM 10.1016/j.ejmech.2009.09.017
Homo sapiens HCT-116 IC50 4370.0 nM 10.1016/j.ejmech.2011.01.057
Homo sapiens HCT-116 IC50 6180.0 nM 10.1016/j.bmc.2008.07.066
Homo sapiens HCT-116 IC50 7700.0 nM 10.1021/acs.jnatprod.0c00977
Homo sapiens HCT-116 IC50 nan None 10.1021/jm061142s
Homo sapiens HCT-116 IC90 8.0 nM 10.1021/jm050996u
Homo sapiens HCT-116 ID50 2.3 nM 10.1016/s0960-894x(02)00153-1
Homo sapiens HCT-116 Inhibition 50.0 % 10.1021/jm7009217
Homo sapiens HCT-116 Inhibition 81.0 % 10.1039/C0MD00179A
Homo sapiens HCT-116 LCK 2.7 None 10.1073/pnas.0611340104
Homo sapiens HCT-116 Ratio 1.0 None 10.1016/S0960-894X(97)10142-1
Homo sapiens HCT-116 Ratio IC50 70.0 None 10.1016/j.bmc.2010.09.028
Homo sapiens HCT-116 Ratio IC50 70.0 None 10.1016/j.bmcl.2010.06.132
Homo sapiens HCT-116 Ratio IC50 1000.0 None 10.1016/j.bmcl.2016.11.025
Homo sapiens HCT-116 T/C 0.2 % 10.1073/pnas.0611340104
Homo sapiens HCT-116 TGI 52.0 % 10.1016/j.ejmech.2020.113023
Homo sapiens HCT-116 TGI 52.6 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HCT-116 TGI 90.57 % 10.1016/j.ejmech.2019.04.005
Homo sapiens HCT-116 Tubulin polymerization ratio 1.0 None 10.1016/0960-894X(95)00453-Z
Homo sapiens HCT-116/VM46 IC50 200.0 nM 10.1016/j.bmcl.2018.02.006
Homo sapiens HCT-116/VM46 ID50 50.0 nM 10.1016/s0960-894x(02)00153-1
Homo sapiens HCT-15 Activity 119.0 mm3 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 Activity 152.0 mm3 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 Activity 288.0 mm3 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 Activity 321.0 mm3 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 Activity 409.0 mm3 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 Activity 638.0 mm3 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 ED50 0.54 uM 10.1021/jm010231w
Homo sapiens HCT-15 GI 37.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens HCT-15 GI 40.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens HCT-15 GI 84.0 % 10.1016/j.ejmech.2009.10.042
Homo sapiens HCT-15 GI50 11.0 nM 10.1016/j.bmcl.2009.04.020
Homo sapiens HCT-15 GI50 125.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HCT-15 GI50 125.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HCT-15 GI50 157.04 nM None
Homo sapiens HCT-15 GI50 158.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens HCT-15 GI50 158.0 nM 10.1021/jm061288r
Homo sapiens HCT-15 GI50 199.53 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens HCT-15 GI50 300.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens HCT-15 IC50 79.4 nM 10.1021/jm061348t
Homo sapiens HCT-15 IC50 90.0 nM 10.1021/jm3013097
Homo sapiens HCT-15 IC50 120.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens HCT-15 IC50 140.0 nM 10.1016/j.bmc.2010.09.028
Homo sapiens HCT-15 IC50 438.0 nM 10.1021/jm040056u
Homo sapiens HCT-15 IC50 190000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens HCT-15 IC50 nan None 10.1016/j.bmcl.2011.01.097
Homo sapiens HCT-15 IC50 nan None 10.1016/j.bmcl.2011.01.111
Homo sapiens HCT-15 Inhibition 48.8 % 10.1016/j.bmcl.2010.06.132
Homo sapiens HCT-15 Log IC50 -7.4 nM 10.1021/jm049405a
Homo sapiens HCT-15 TGI 15850.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens HCT-15 TGI 15850.0 nM 10.1021/jm061288r
Homo sapiens HCT-15 TGI nan None 10.1016/j.bmcl.2018.11.053
Homo sapiens HCT-15 TGI nan None 10.1016/j.ejmech.2018.07.011
Homo sapiens HCT-8 EC50 0.21 ug.mL-1 10.1016/j.bmcl.2008.06.099
Homo sapiens HCT-8 EC50 0.21 ug.mL-1 10.1021/np800622a
Homo sapiens HCT-8 ED50 0.011 ug ml-1 10.1021/jm020548b
Homo sapiens HCT-8 ED50 0.011 ug ml-1 10.1021/np030241v
Homo sapiens HCT-8 ED50 0.06 ug ml-1 10.1016/j.bmcl.2007.06.083
Homo sapiens HCT-8 ED50 100.0 nM 10.1016/j.bmc.2011.01.001
Homo sapiens HCT-8 GI50 100.0 nM 10.1016/j.bmc.2011.02.004
Homo sapiens HCT-8 IC50 3.6 nM 10.1021/np900302w
Homo sapiens HCT-8 IC50 13.0 nM 10.1021/np0500575
Homo sapiens HCT-8 IC50 17.4 nM 10.1016/j.ejmech.2017.07.040
Homo sapiens HCT-8 IC50 20.0 nM 10.1021/acs.jmedchem.1c01775
Homo sapiens HCT-8 IC50 28.0 nM 10.1016/j.ejmech.2018.11.070
Homo sapiens HCT-8 IC50 28.0 nM 10.1016/j.ejmech.2021.113316
Homo sapiens HCT-8 IC50 36.9 nM 10.1021/acs.jmedchem.6b00158
Homo sapiens HCT-8 IC50 37.0 nM 10.1021/np0701531
Homo sapiens HCT-8 IC50 37.0 nM 10.1021/np800716f
Homo sapiens HCT-8 IC50 51.0 nM 10.1016/j.bmcl.2010.07.085
Homo sapiens HCT-8 IC50 51.0 nM 10.1016/j.bmcl.2011.04.030
Homo sapiens HCT-8 IC50 51.0 nM 10.1021/np200920c
Homo sapiens HCT-8 IC50 51.0 nM 10.1021/np3000443
Homo sapiens HCT-8 IC50 51.0 nM 10.1021/np3008864
Homo sapiens HCT-8 IC50 86.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens HCT-8 IC50 130.0 nM 10.1021/acs.jmedchem.1c01775
Homo sapiens HCT-8 IC50 170.0 nM 10.1016/j.ejmech.2019.01.076
Homo sapiens HCT-8 IC50 189.4 nM 10.1021/acs.jmedchem.6b00158
Homo sapiens HCT-8 IC50 240.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens HCT-8 IC50 670.0 nM 10.1021/np1001863
Homo sapiens HCT-8 IC50 2590.0 nM 10.1016/j.ejmech.2021.113316
Homo sapiens HCT-8 IC50 3290.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens HCT-8 IC50 3600.0 nM 10.1021/np900089v
Homo sapiens HCT-8 IC50 8700.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens HCT-8 IC50 13300.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens HCT-8 Ratio IC50 6.57 None 10.1021/acs.jmedchem.6b00021
Homo sapiens HCT-8 Ratio IC50 53.2 None 10.1021/jm500849z
Homo sapiens HDLM-2 IC50 43.92 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 11.63 nM 10.6019/CHEMBL1201861
Homo sapiens Heat shock protein HSP 90-alpha IC50 nan None 10.1016/j.bmcl.2020.127168
Homo sapiens HEK293 IC50 0.008 ug.mL-1 10.1016/j.ejmech.2014.10.013
Homo sapiens HEK293 IC50 10.0 nM 10.1016/j.bmcl.2007.04.058
Homo sapiens HEK293 IC50 16.3 nM 10.1016/j.ejmech.2020.113050
Homo sapiens HEK293 IC50 40.0 nM 10.1016/j.bmc.2015.03.002
Homo sapiens HEK293 IC50 360.0 nM 10.1016/j.bmc.2015.03.002
Homo sapiens HEK293 IC50 5800.0 nM 10.1016/j.bmc.2021.116252
Homo sapiens HEK293 IC50 43000.0 nM 10.1016/j.ejmech.2009.04.022
Homo sapiens HEK293 IC50 nan None 10.1021/acs.jnatprod.7b00247
Homo sapiens HEK293 IC50 nan None 10.1039/C4MD00573B
Homo sapiens HEK293 Potency 290.8 nM None
Homo sapiens HEK293 Ratio IC50 9.0 None 10.1016/j.bmc.2015.03.002
Homo sapiens HEK-293T Activity nan None 10.1016/j.ejmech.2020.113068
Homo sapiens HEK-293T CC50 20.0 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens HEK-293T Growth Rate -0.69 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.41 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.33 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.22 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.21 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.08 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate -0.02 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T Growth Rate 0.05 None 10.6019/CHEMBL5303304
Homo sapiens HEK-293T IC50 1.76 nM 10.1021/acs.jnatprod.1c00100
Homo sapiens HEK-293T IC50 2.3 nM 10.1016/j.bmc.2018.02.024
Homo sapiens HEK-293T IC50 6.7 nM 10.1021/acs.jmedchem.1c00705
Homo sapiens HEK-293T IC50 10.0 nM 10.1016/j.ejmech.2020.113068
Homo sapiens HEK-293T IC50 36400.0 nM 10.1021/acs.jmedchem.1c01452
Homo sapiens HEL IC50 41.4 nM 10.6019/CHEMBL1201861
Homo sapiens HEL 92.1.7 Imax 83.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens HEL 92.1.7 LC50 20.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens HeLa Activity 2.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens HeLa Activity 2.12 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 2.24 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 4.55 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 5.2 None 10.1021/jm061385k
Homo sapiens HeLa Activity 10.6 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 19.7 uM 10.1016/j.ejmech.2022.114832
Homo sapiens HeLa Activity 26.7 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 34.7 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 35.0 nM 10.1016/j.ejmech.2017.06.001
Homo sapiens HeLa Activity 44.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens HeLa Activity 48.9 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HeLa Activity 52.4 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 56.5 % 10.1039/C0MD00235F
Homo sapiens HeLa Activity 66.6 % 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity 68.74 % 10.1021/acsmedchemlett.9b00304
Homo sapiens HeLa Activity 76.3 % 10.1039/C0MD00235F
Homo sapiens HeLa Activity 86.3 % 10.1039/C0MD00235F
Homo sapiens HeLa Activity 96.1 % 10.1039/C0MD00235F
Homo sapiens HeLa Activity nan None 10.1016/j.bmc.2019.02.002
Homo sapiens HeLa Activity nan None 10.1016/j.bmcl.2009.05.093
Homo sapiens HeLa Activity nan None 10.1016/j.bmcl.2013.01.020
Homo sapiens HeLa Activity nan None 10.1016/j.bmcl.2016.11.025
Homo sapiens HeLa Activity nan None 10.1016/j.ejmech.2012.12.008
Homo sapiens HeLa Activity nan None 10.1016/j.ejmech.2012.12.021
Homo sapiens HeLa Activity nan None 10.1016/j.ejmech.2013.09.046
Homo sapiens HeLa Activity nan None 10.1016/j.ejmech.2021.113746
Homo sapiens HeLa Activity nan None 10.1021/acs.jmedchem.0c02144
Homo sapiens HeLa Activity nan None 10.1021/acs.jmedchem.7b00592
Homo sapiens HeLa Activity nan None 10.1021/acs.jmedchem.9b02035
Homo sapiens HeLa Activity nan None 10.1021/acsmedchemlett.9b00526
Homo sapiens HeLa Activity nan None 10.1021/jm200757g
Homo sapiens HeLa Activity nan None 10.1021/jm300176j
Homo sapiens HeLa Activity nan None 10.1021/jm401665x
Homo sapiens HeLa Activity nan None 10.1039/C3MD00034F
Homo sapiens HeLa Activity nan None 10.1039/C5MD00155B
Homo sapiens HeLa Activity nan None None
Homo sapiens HeLa CC50 0.0048 ug.mL-1 10.1016/j.bmcl.2016.05.093
Homo sapiens HeLa CC50 0.01 ug.mL-1 10.1021/np040062t
Homo sapiens HeLa CC50 0.01 ug.mL-1 10.1021/np060587g
Homo sapiens HeLa GI 45.0 % 10.1007/s00044-012-0106-y
Homo sapiens HeLa GI 101.04 % 10.1016/j.bmc.2013.11.037
Homo sapiens HeLa GI nan None 10.1016/j.bmcl.2013.11.032
Homo sapiens HeLa GI50 0.004 ug.mL-1 10.1021/acsmedchemlett.6b00077
Homo sapiens HeLa GI50 0.0048 ug.mL-1 10.1016/j.bmcl.2016.03.045
Homo sapiens HeLa GI50 0.0048 ug.mL-1 10.1016/j.bmcl.2019.03.020
Homo sapiens HeLa GI50 0.0048 ug.mL-1 10.1016/j.ejmech.2017.01.009
Homo sapiens HeLa GI50 0.0048 ug.mL-1 10.1016/j.ejmech.2017.03.065
Homo sapiens HeLa GI50 0.0048 ug.mL-1 10.1021/acs.jmedchem.0c01833
Homo sapiens HeLa GI50 0.005 ug.mL-1 10.1016/j.bmcl.2016.02.043
Homo sapiens HeLa GI50 0.033 nM 10.1016/j.bmcl.2011.09.069
Homo sapiens HeLa GI50 0.14 ug.mL-1 10.1016/j.bmcl.2015.11.071
Homo sapiens HeLa GI50 2.34 nM 10.1021/acs.jmedchem.6b00324
Homo sapiens HeLa GI50 3.2 nM 10.1021/acs.jnatprod.1c00211
Homo sapiens HeLa GI50 3.206 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens HeLa GI50 7.0 nM 10.1016/s0960-894x(99)00276-0
Homo sapiens HeLa GI50 10.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HeLa GI50 10.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens HeLa GI50 16.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HeLa GI50 20.0 nM 10.1016/j.bmcl.2008.11.067
Homo sapiens HeLa GI50 20.0 nM 10.1016/j.bmcl.2010.05.074
Homo sapiens HeLa GI50 20.0 nM 10.1016/j.bmcl.2015.03.032
Homo sapiens HeLa GI50 23.0 nM 10.1016/j.ejmech.2016.02.059
Homo sapiens HeLa GI50 25.0 nM 10.1016/j.bmcl.2014.09.018
Homo sapiens HeLa GI50 25.0 nM 10.1016/j.bmcl.2016.05.021
Homo sapiens HeLa GI50 25.0 nM 10.1016/j.ejmech.2014.10.051
Homo sapiens HeLa GI50 2820.0 nM 10.1016/j.bmcl.2011.07.049
Homo sapiens HeLa GI90 0.075 ug ml-1 10.1016/j.bmcl.2016.02.043
Homo sapiens HeLa GI90 0.075 ug ml-1 10.1016/j.bmcl.2016.03.045
Homo sapiens HeLa GI90 0.075 ug ml-1 10.1016/j.bmcl.2019.03.020
Homo sapiens HeLa GI90 0.075 ug ml-1 10.1016/j.ejmech.2017.03.065
Homo sapiens HeLa GI90 0.075 ug ml-1 10.1021/acsmedchemlett.6b00077
Homo sapiens HeLa IC50 0.008 ug.mL-1 10.1021/jm401665x
Homo sapiens HeLa IC50 0.1 ug.mL-1 10.1016/j.bmcl.2015.08.057
Homo sapiens HeLa IC50 0.38 ug.mL-1 10.1016/j.bmcl.2012.08.074
Homo sapiens HeLa IC50 0.47 ug.mL-1 10.1016/j.ejmech.2014.03.021
Homo sapiens HeLa IC50 0.61 ug.mL-1 10.1021/np9005579
Homo sapiens HeLa IC50 0.7 nM 10.1016/j.bmc.2014.05.048
Homo sapiens HeLa IC50 1.0 nM 10.1016/j.bmc.2008.11.036
Homo sapiens HeLa IC50 1.0 nM 10.1021/acs.jnatprod.7b00650
Homo sapiens HeLa IC50 1.0 nM 10.1021/acs.jnatprod.9b00340
Homo sapiens HeLa IC50 1.0 nM 10.1021/jm301151t
Homo sapiens HeLa IC50 1.1 nM 10.1016/j.ejmech.2017.06.001
Homo sapiens HeLa IC50 1.18 ug.mL-1 10.1016/j.ejmech.2014.10.013
Homo sapiens HeLa IC50 1.2 nM 10.1021/jm200757g
Homo sapiens HeLa IC50 1.2 nM 10.1021/np400435t
Homo sapiens HeLa IC50 1.21 nM 10.1016/j.bmc.2014.04.049
Homo sapiens HeLa IC50 1.38 nM 10.1021/jm2007722
Homo sapiens HeLa IC50 1.4 nM 10.1021/acs.jnatprod.7b00006
Homo sapiens HeLa IC50 1.4 nM 10.1021/acs.jnatprod.9b00875
Homo sapiens HeLa IC50 1.4 nM 10.1021/np4005079
Homo sapiens HeLa IC50 1.5 nM 10.1016/j.bmc.2017.04.012
Homo sapiens HeLa IC50 1.5 nM 10.1021/np700717s
Homo sapiens HeLa IC50 1.6 nM 10.1016/j.bmc.2012.12.010
Homo sapiens HeLa IC50 1.6 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HeLa IC50 1.6 nM 10.1016/j.bmc.2020.115887
Homo sapiens HeLa IC50 1.6 nM 10.1021/jm101010n
Homo sapiens HeLa IC50 1.6 nM 10.1021/jm400639z
Homo sapiens HeLa IC50 1.7 nM 10.1021/np400297p
Homo sapiens HeLa IC50 1.9 nM 10.1016/j.bmc.2015.03.061
Homo sapiens HeLa IC50 2.5 nM 10.1021/np4007487
Homo sapiens HeLa IC50 2.6 nM 10.1021/np200076t
Homo sapiens HeLa IC50 2.8 nM 10.1016/j.bmc.2018.09.025
Homo sapiens HeLa IC50 2.8 nM 10.1016/j.bmc.2021.116061
Homo sapiens HeLa IC50 2.8 nM 10.1016/j.bmc.2023.117217
Homo sapiens HeLa IC50 2.8 nM 10.1016/j.bmcl.2018.07.039
Homo sapiens HeLa IC50 2.8 nM 10.1021/acs.jmedchem.6b00237
Homo sapiens HeLa IC50 2.93 nM 10.1016/j.bmcl.2012.06.102
Homo sapiens HeLa IC50 3.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens HeLa IC50 3.0 nM 10.1016/j.ejmech.2017.12.004
Homo sapiens HeLa IC50 3.0 nM 10.1016/j.ejmech.2020.112323
Homo sapiens HeLa IC50 3.0 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens HeLa IC50 3.0 ug.mL-1 10.1021/np800167x
Homo sapiens HeLa IC50 3.01 nM 10.1021/acs.jnatprod.5b00650
Homo sapiens HeLa IC50 3.2 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens HeLa IC50 3.3 nM 10.1016/j.ejmech.2019.111587
Homo sapiens HeLa IC50 3.5 nM 10.1021/np500768s
Homo sapiens HeLa IC50 4.0 nM 10.1021/acs.jnatprod.0c00064
Homo sapiens HeLa IC50 4.3 nM 10.1021/acs.jnatprod.1c00677
Homo sapiens HeLa IC50 4.6 nM 10.1021/acs.jnatprod.7b00857
Homo sapiens HeLa IC50 5.0 nM 10.1021/acs.jnatprod.9b00140
Homo sapiens HeLa IC50 5.0 nM 10.1021/jm3013097
Homo sapiens HeLa IC50 5.3 nM 10.1021/ml4004793
Homo sapiens HeLa IC50 5.6 nM 10.1021/np070256j
Homo sapiens HeLa IC50 6.0 nM 10.1016/j.ejmech.2020.113102
Homo sapiens HeLa IC50 6.0 nM 10.1016/j.ejmech.2022.114832
Homo sapiens HeLa IC50 6.25 nM 10.1016/j.bmc.2021.116551
Homo sapiens HeLa IC50 6.3 nM 10.1021/jm301864s
Homo sapiens HeLa IC50 7.7 nM 10.1016/j.bmc.2014.05.048
Homo sapiens HeLa IC50 7.7 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HeLa IC50 7.7 nM 10.1021/jm101010n
Homo sapiens HeLa IC50 8.0 nM 10.1016/j.ejmech.2014.10.075
Homo sapiens HeLa IC50 8.0 nM 10.1016/j.ejmech.2021.113629
Homo sapiens HeLa IC50 8.0 nM 10.1021/acs.jnatprod.6b00508
Homo sapiens HeLa IC50 8.0 nM 10.1021/acs.jnatprod.9b00183
Homo sapiens HeLa IC50 8.0 nM 10.1021/jm0510676
Homo sapiens HeLa IC50 8.0 nM 10.1021/jm070534b
Homo sapiens HeLa IC50 8.21 nM 10.1016/j.ejmech.2017.03.031
Homo sapiens HeLa IC50 8.9 nM 10.1016/j.bmcl.2010.07.100
Homo sapiens HeLa IC50 9.05 nM 10.1021/jm2007722
Homo sapiens HeLa IC50 9.1 nM 10.1021/np4005079
Homo sapiens HeLa IC50 10.0 nM 10.1016/j.bmc.2014.04.049
Homo sapiens HeLa IC50 10.0 nM 10.1016/j.ejmech.2014.11.068
Homo sapiens HeLa IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens HeLa IC50 11.2 nM 10.1021/jm301151t
Homo sapiens HeLa IC50 12.62 nM 10.1016/j.bmcl.2016.06.012
Homo sapiens HeLa IC50 16.0 nM 10.1021/ml4004793
Homo sapiens HeLa IC50 18.0 nM 10.1021/acs.jmedchem.6b00071
Homo sapiens HeLa IC50 18.9 nM 10.1021/acsmedchemlett.5b00418
Homo sapiens HeLa IC50 19.87 nM 10.1016/j.bmcl.2016.05.023
Homo sapiens HeLa IC50 20.0 nM 10.1016/j.bmcl.2007.09.065
Homo sapiens HeLa IC50 20.0 nM 10.1021/jm100659v
Homo sapiens HeLa IC50 21.1 nM 10.1016/j.bmc.2017.04.012
Homo sapiens HeLa IC50 23.0 nM 10.1016/j.bmcl.2018.02.022
Homo sapiens HeLa IC50 23.29 nM 10.1016/j.bmcl.2016.06.012
Homo sapiens HeLa IC50 24.0 nM 10.1016/j.bmc.2018.09.025
Homo sapiens HeLa IC50 24.0 nM 10.1016/j.bmc.2021.116061
Homo sapiens HeLa IC50 24.0 nM 10.1016/j.bmc.2023.117217
Homo sapiens HeLa IC50 24.0 nM 10.1021/acs.jmedchem.6b00237
Homo sapiens HeLa IC50 28.6 nM 10.1016/j.ejmech.2020.113050
Homo sapiens HeLa IC50 28.6 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens HeLa IC50 30.0 nM 10.1021/np900788e
Homo sapiens HeLa IC50 32.9 nM 10.1016/j.bmc.2015.03.061
Homo sapiens HeLa IC50 39.0 nM 10.1016/j.ejmech.2022.114372
Homo sapiens HeLa IC50 41.0 nM 10.1016/j.ejmech.2020.112519
Homo sapiens HeLa IC50 46.0 nM 10.1021/acs.jnatprod.8b00197
Homo sapiens HeLa IC50 50.0 nM 10.1021/acs.jnatprod.1c01194
Homo sapiens HeLa IC50 70.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens HeLa IC50 96.0 nM 10.1016/j.ejmech.2014.06.002
Homo sapiens HeLa IC50 99.0 nM 10.1016/j.ejmech.2015.11.009
Homo sapiens HeLa IC50 100.0 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens HeLa IC50 190.0 nM 10.1021/np900788e
Homo sapiens HeLa IC50 230.0 nM 10.1016/j.bmcl.2021.128503
Homo sapiens HeLa IC50 290.0 nM 10.1016/j.ejmech.2014.05.084
Homo sapiens HeLa IC50 380.0 nM 10.1016/j.bmcl.2015.04.051
Homo sapiens HeLa IC50 400.0 ug.mL-1 10.1016/j.bmcl.2019.126730
Homo sapiens HeLa IC50 410.0 nM 10.1016/j.bmcl.2014.07.035
Homo sapiens HeLa IC50 470.0 nM 10.1016/j.bmcl.2006.06.007
Homo sapiens HeLa IC50 600.0 nM 10.1021/np2002918
Homo sapiens HeLa IC50 890.0 nM 10.1016/j.ejmech.2012.03.024
Homo sapiens HeLa IC50 1000.0 nM 10.1016/j.bmcl.2012.09.104
Homo sapiens HeLa IC50 1300.0 nM 10.1016/j.bmcl.2014.10.088
Homo sapiens HeLa IC50 1375.0 nM 10.1021/jm301864s
Homo sapiens HeLa IC50 1700.0 nM 10.1021/acs.jnatprod.6b00561
Homo sapiens HeLa IC50 2290.0 nM 10.1016/j.bmc.2015.11.007
Homo sapiens HeLa IC50 2900.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens HeLa IC50 3110.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens HeLa IC50 5000.0 nM 10.1021/np500382k
Homo sapiens HeLa IC50 5300.0 nM 10.1016/j.bmc.2016.11.026
Homo sapiens HeLa IC50 6420.0 nM 10.1016/j.ejmech.2017.11.023
Homo sapiens HeLa IC50 6620.0 nM 10.1016/j.ejmech.2011.03.050
Homo sapiens HeLa IC50 10900.0 nM 10.1016/j.ejmech.2013.12.059
Homo sapiens HeLa IC50 10900.0 nM 10.1016/j.ejmech.2018.01.020
Homo sapiens HeLa IC50 11200.0 nM 10.1016/j.bmcl.2012.09.104
Homo sapiens HeLa IC50 12000.0 nM 10.1021/np400614f
Homo sapiens HeLa IC50 16000.0 nM 10.1016/j.bmc.2016.11.026
Homo sapiens HeLa IC50 19310.0 nM 10.1039/C6MD00234J
Homo sapiens HeLa IC50 28450.0 nM 10.1016/j.ejmech.2012.12.022
Homo sapiens HeLa IC50 45780.0 nM 10.1016/j.bmc.2019.02.044
Homo sapiens HeLa IC50 nan None 10.1016/j.bmc.2007.05.070
Homo sapiens HeLa IC50 nan None 10.1016/j.bmcl.2014.08.010
Homo sapiens HeLa IC50 nan None 10.1021/jm061142s
Homo sapiens HeLa MIC 5.32 ug.mL-1 10.1016/j.bmcl.2015.11.071
Homo sapiens HeLa Ratio 4.7 None 10.1021/jm101010n
Homo sapiens HeLa Ratio IC50 3.0 None 10.1016/j.bmc.2016.11.026
Homo sapiens HeLa Ratio IC50 4.0 None 10.1016/j.ejmech.2017.06.001
Homo sapiens HeLa Ratio IC50 4.7 None 10.1016/j.bmc.2018.04.010
Homo sapiens HeLa Ratio IC50 5.8 None 10.1016/j.bmc.2012.12.010
Homo sapiens HeLa Ratio IC50 6.5 None 10.1021/np4005079
Homo sapiens HeLa Ratio IC50 6.6 None 10.1021/jm2007722
Homo sapiens HeLa Ratio IC50 7.72 None 10.1016/j.bmcl.2016.11.025
Homo sapiens HeLa Ratio IC50 8.3 None 10.1016/j.bmc.2014.04.049
Homo sapiens HeLa Ratio IC50 8.6 None 10.1021/acs.jmedchem.6b00237
Homo sapiens HeLa Ratio IC50 11.0 None 10.1016/j.bmc.2014.05.048
Homo sapiens HeLa Ratio IC50 11.2 None 10.1016/j.bmcl.2012.09.104
Homo sapiens HeLa Ratio IC50 11.2 None 10.1021/jm301151t
Homo sapiens HeLa Ratio IC50 14.0 None 10.1016/j.bmc.2017.04.012
Homo sapiens HeLa Ratio IC50 17.3 None 10.1016/j.bmc.2015.03.061
Homo sapiens HeLa Ratio IC50 186.4 None 10.1016/j.ejmech.2017.03.031
Homo sapiens HeLa Ratio IC50 218.3 None 10.1021/jm301864s
Homo sapiens HeLa TGI 46.5 % 10.1021/acs.jmedchem.8b01742
Homo sapiens HeLa S3 IC50 13.0 nM 10.1016/j.ejmech.2018.05.025
Homo sapiens HEp-2 GI 29.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens HEp-2 GI 55.0 % 10.1016/j.ejmech.2009.11.001
Homo sapiens HEp-2 GI 75.0 % 10.1016/j.ejmech.2009.10.042
Homo sapiens HEp-2 IC50 110.0 nM 10.1007/s00044-011-9824-9
Homo sapiens Hep 3B2 IC50 730.0 nM 10.1016/j.bmcl.2017.02.043
Homo sapiens HepG2 Activity 19.0 % 10.1016/j.ejmech.2021.113865
Homo sapiens HepG2 Activity 59.6 % 10.1016/j.ejmech.2020.112181
Homo sapiens HepG2 Activity nan None 10.1016/j.bmcl.2017.12.032
Homo sapiens HepG2 Activity nan None 10.1021/acs.jmedchem.1c00404
Homo sapiens HepG2 Activity nan None 10.1021/acs.jmedchem.5b00310
Homo sapiens HepG2 Activity nan None 10.1021/jm500561a
Homo sapiens HepG2 CC50 120.0 nM 10.1016/j.bmcl.2017.12.032
Homo sapiens HepG2 ED50 100.0 nM 10.1016/j.bmc.2011.01.001
Homo sapiens HepG2 GI 87.91 % 10.1021/np400002p
Homo sapiens HepG2 GI50 1.0 nM 10.1016/j.bmc.2009.01.024
Homo sapiens HepG2 GI50 10.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HepG2 GI50 16.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens HepG2 GI50 59.0 nM 10.1021/np800643n
Homo sapiens HepG2 GI50 180.0 nM 10.1021/jm300705j
Homo sapiens HepG2 GI50 nan None 10.1016/j.ejmech.2010.11.013
Homo sapiens HepG2 IC50 0.008 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens HepG2 IC50 0.05 ug.mL-1 10.1021/np0604533
Homo sapiens HepG2 IC50 0.18 ug.mL-1 10.1021/np050082a
Homo sapiens HepG2 IC50 0.19 nM 10.1016/j.bmcl.2014.03.091
Homo sapiens HepG2 IC50 0.19 nM 10.1016/j.bmcl.2014.09.065
Homo sapiens HepG2 IC50 0.2 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens HepG2 IC50 0.44 nM 10.1021/np3003639
Homo sapiens HepG2 IC50 0.59 ug.mL-1 10.1016/j.ejmech.2014.03.021
Homo sapiens HepG2 IC50 0.66 ug.mL-1 10.1016/j.ejmech.2020.112609
Homo sapiens HepG2 IC50 0.69 ug.mL-1 10.1021/np070089n
Homo sapiens HepG2 IC50 0.762 nM 10.1016/j.bmc.2020.115557
Homo sapiens HepG2 IC50 1.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens HepG2 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens HepG2 IC50 1.06 10'-8mg/ml 10.1016/j.bmcl.2016.02.055
Homo sapiens HepG2 IC50 1.9 nM 10.1021/acs.jnatprod.8b01084
Homo sapiens HepG2 IC50 4.3 ug.mL-1 10.1039/d2md00192f
Homo sapiens HepG2 IC50 4.4 nM 10.1021/np2004038
Homo sapiens HepG2 IC50 4.4 nM 10.1021/np200920c
Homo sapiens HepG2 IC50 4.6 nM 10.1021/np5003498
Homo sapiens HepG2 IC50 5.9 nM 10.1021/np070458f
Homo sapiens HepG2 IC50 6.0 nM 10.1016/j.ejmech.2013.04.008
Homo sapiens HepG2 IC50 6.3 nM 10.1021/acs.jnatprod.7b00014
Homo sapiens HepG2 IC50 6.4 nM 10.1016/j.bmcl.2014.03.011
Homo sapiens HepG2 IC50 6.9 ug.mL-1 10.1016/j.bmcl.2006.09.068
Homo sapiens HepG2 IC50 7.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens HepG2 IC50 7.0 nM 10.1016/j.bmcl.2011.12.074
Homo sapiens HepG2 IC50 7.6 nM 10.1021/acs.jnatprod.6b00887
Homo sapiens HepG2 IC50 8.0 nM 10.1021/acs.jnatprod.9b00183
Homo sapiens HepG2 IC50 9.0 nM 10.1016/j.bmc.2018.10.040
Homo sapiens HepG2 IC50 9.0 nM 10.1016/j.bmcl.2008.06.039
Homo sapiens HepG2 IC50 9.0 nM 10.1016/j.bmcl.2015.01.056
Homo sapiens HepG2 IC50 9.0 nM 10.1016/j.ejmech.2019.112022
Homo sapiens HepG2 IC50 10.1 nM 10.1016/j.bmcl.2021.128355
Homo sapiens HepG2 IC50 10.1 nM 10.1021/acs.jmedchem.6b00071
Homo sapiens HepG2 IC50 10.2 nM 10.1016/j.bmcl.2017.12.039
Homo sapiens HepG2 IC50 12.6 nM 10.1016/j.ejmech.2020.113049
Homo sapiens HepG2 IC50 13.0 nM 10.1016/j.bmc.2022.116626
Homo sapiens HepG2 IC50 16.6 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens HepG2 IC50 20.0 nM 10.1016/j.bmcl.2017.06.019
Homo sapiens HepG2 IC50 21.71 nM 10.1016/j.ejmech.2016.03.029
Homo sapiens HepG2 IC50 28.0 nM 10.1021/jm500024v
Homo sapiens HepG2 IC50 38.0 nM 10.1021/jm500849z
Homo sapiens HepG2 IC50 45.0 nM 10.1016/j.ejmech.2015.02.031
Homo sapiens HepG2 IC50 46.8 nM 10.1021/np0704957
Homo sapiens HepG2 IC50 50.0 nM 10.1016/j.bmcl.2011.11.016
Homo sapiens HepG2 IC50 54.0 nM 10.1021/np300551g
Homo sapiens HepG2 IC50 60.0 nM 10.1021/acs.jnatprod.1c01194
Homo sapiens HepG2 IC50 67.27 nM 10.1016/j.ejmech.2014.05.043
Homo sapiens HepG2 IC50 80.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens HepG2 IC50 80.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens HepG2 IC50 80.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens HepG2 IC50 84.0 nM 10.1016/j.ejmech.2014.06.002
Homo sapiens HepG2 IC50 101.65 ug.mL-1 10.1016/j.bmcl.2019.126730
Homo sapiens HepG2 IC50 110.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens HepG2 IC50 180.0 nM 10.1016/j.ejmech.2019.06.006
Homo sapiens HepG2 IC50 190.0 nM 10.1016/j.ejmech.2021.113685
Homo sapiens HepG2 IC50 220.0 nM 10.1016/j.ejmech.2022.114439
Homo sapiens HepG2 IC50 220.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens HepG2 IC50 300.0 nM 10.1016/j.bmcl.2017.02.043
Homo sapiens HepG2 IC50 300.0 nM 10.1021/jm0510676
Homo sapiens HepG2 IC50 300.0 nM 10.1021/jm070534b
Homo sapiens HepG2 IC50 620.0 nM 10.1016/j.bmc.2008.07.066
Homo sapiens HepG2 IC50 820.0 nM 10.1016/j.bmcl.2007.09.065
Homo sapiens HepG2 IC50 990.0 nM 10.1016/j.bmcl.2014.07.035
Homo sapiens HepG2 IC50 1217.0 nM 10.1016/j.ejmech.2015.09.019
Homo sapiens HepG2 IC50 2037.0 nM 10.1021/jm500561a
Homo sapiens HepG2 IC50 2600.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens HepG2 IC50 2660.0 nM 10.1016/j.ejmech.2018.04.042
Homo sapiens HepG2 IC50 2700.0 nM 10.1021/np500583z
Homo sapiens HepG2 IC50 3900.0 nM 10.1016/j.bmcl.2020.127330
Homo sapiens HepG2 IC50 4150.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens HepG2 IC50 6700.0 nM 10.1021/acs.jnatprod.6b00561
Homo sapiens HepG2 IC50 6900.0 nM 10.1021/np050417o
Homo sapiens HepG2 IC50 8100.0 nM 10.1016/j.bmcl.2007.04.030
Homo sapiens HepG2 IC50 8400.0 nM 10.1021/acs.jnatprod.0c00698
Homo sapiens HepG2 IC50 9490.0 nM 10.1021/np0600447
Homo sapiens HepG2 IC50 10000.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens HepG2 IC50 10300.0 nM 10.1016/j.bmc.2018.12.023
Homo sapiens HepG2 IC50 10320.0 nM 10.1016/j.ejmech.2011.03.050
Homo sapiens HepG2 IC50 10320.0 nM 10.1016/j.ejmech.2012.07.047
Homo sapiens HepG2 IC50 10320.0 nM 10.1016/j.ejmech.2012.07.051
Homo sapiens HepG2 IC50 10320.0 nM 10.1016/j.ejmech.2016.10.012
Homo sapiens HepG2 IC50 15600.0 nM 10.1021/ml500289h
Homo sapiens HepG2 IC50 30700.0 nM 10.1016/j.bmcl.2012.02.009
Homo sapiens HepG2 IC50 30740.0 nM 10.1016/j.bmc.2011.05.017
Homo sapiens HepG2 IC50 61800.0 nM 10.1016/j.ejmech.2012.12.022
Homo sapiens HepG2 IC50 100000.0 nM 10.1039/C4MD00344F
Homo sapiens HepG2 IC50 592000.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens HepG2 IC50 8100000.0 nM 10.1021/np068066g
Homo sapiens HepG2 IC90 1.13 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens HepG2 IC90 78.92 ug.mL-1 10.1021/np400002p
Homo sapiens HepG2 Imax 54.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens HepG2 LC50 nan None 10.1016/j.ejmech.2010.11.013
Homo sapiens HepG2 Potency 12589.3 nM None
Homo sapiens HepG2 TGI 32.4 % 10.1016/j.ejmech.2013.01.007
Homo sapiens HepG2 TGI 59.1 % 10.1016/j.ejmech.2013.01.007
Homo sapiens HepG2 TGI 99.4 % 10.1016/j.ejmech.2020.112181
Homo sapiens HepG2 TGI nan None 10.1016/j.ejmech.2010.11.013
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HEY Activity 10.0 % 10.1021/acs.jnatprod.8b00111
Homo sapiens HEY Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens HEY IC50 104.1 nM 10.1021/acs.jnatprod.7b00347
Homo sapiens HEY IC50 2700.0 nM 10.1021/acs.jnatprod.7b01047
Homo sapiens HFF-1 IC50 10000.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens HGC-27 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens HGC-27 IC50 8.4 nM 10.1021/acs.jnatprod.0c00189
Homo sapiens HGC-27 IC50 28.0 nM 10.1021/acs.jnatprod.8b00197
Homo sapiens HGC-27 IC50 777.8 nM 10.1021/np070256j
Homo sapiens HH IC50 71.57 nM 10.6019/CHEMBL1201861
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmc.2019.02.046
Homo sapiens Histone deacetylase 6 Inhibition -56.9 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -5.37 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 Activity 0.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens HL-60 Activity 10.5 % 10.1021/jm070194u
Homo sapiens HL-60 Activity 18.0 % 10.1021/acs.jnatprod.8b00641
Homo sapiens HL-60 Activity 19.0 % 10.1021/acs.jnatprod.8b00557
Homo sapiens HL-60 Activity 22.2 % 10.1021/jm070194u
Homo sapiens HL-60 Activity 24.0 % 10.1021/acs.jnatprod.8b00641
Homo sapiens HL-60 Activity 28.0 % 10.1021/acs.jnatprod.8b00557
Homo sapiens HL-60 Activity 53.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens HL-60 Activity 53.0 % 10.1021/acs.jnatprod.8b00557
Homo sapiens HL-60 Activity 58.0 % 10.1021/acs.jnatprod.8b00641
Homo sapiens HL-60 Activity 67.3 % 10.1021/jm070194u
Homo sapiens HL-60 GI 96.8 % 10.1016/j.bmc.2013.11.037
Homo sapiens HL-60 GI50 4.266 nM None
Homo sapiens HL-60 GI50 5.012 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens HL-60 IC50 0.001 ug.mL-1 10.1016/S0960-894X(97)00058-9
Homo sapiens HL-60 IC50 0.004 ug.mL-1 10.1016/j.ejmech.2009.07.027
Homo sapiens HL-60 IC50 0.005 ug.mL-1 10.1021/np400110g
Homo sapiens HL-60 IC50 2.0 nM 10.1016/j.bmcl.2013.07.032
Homo sapiens HL-60 IC50 2.0 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens HL-60 IC50 2.0 nM 10.1021/acs.jnatprod.6b00873
Homo sapiens HL-60 IC50 2.0 ug.mL-1 10.1021/np800167x
Homo sapiens HL-60 IC50 2.2 nM 10.1021/acs.jnatprod.1c00677
Homo sapiens HL-60 IC50 2.5 nM 10.1016/j.bmcl.2020.127168
Homo sapiens HL-60 IC50 2.6 nM 10.1016/j.bmcl.2018.02.022
Homo sapiens HL-60 IC50 2.82 nM 10.1016/j.bmcl.2012.06.102
Homo sapiens HL-60 IC50 3.4 nM 10.1021/np200452m
Homo sapiens HL-60 IC50 5.0 nM 10.1016/j.bmcl.2006.07.020
Homo sapiens HL-60 IC50 5.0 nM 10.1016/j.bmcl.2008.02.029
Homo sapiens HL-60 IC50 5.8 nM 10.1021/jm301581y
Homo sapiens HL-60 IC50 8.0 nM 10.1016/j.bmc.2021.116495
Homo sapiens HL-60 IC50 8.0 nM 10.1016/j.bmcl.2018.05.038
Homo sapiens HL-60 IC50 8.0 nM 10.1016/j.ejmech.2019.02.025
Homo sapiens HL-60 IC50 8.0 nM 10.1016/j.ejmech.2022.114844
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.0c00298
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.1c00342
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.5b00057
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.6b00508
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.7b00150
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.7b00163
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.7b00514
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.7b00723
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.7b00909
Homo sapiens HL-60 IC50 8.0 nM 10.1021/acs.jnatprod.9b00022
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np100110u
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np300772e
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np400041y
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np400190n
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np400287r
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np4005823
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np400600c
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np400669t
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np4010135
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np500626x
Homo sapiens HL-60 IC50 8.0 nM 10.1021/np501057f
Homo sapiens HL-60 IC50 9.656 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60 IC50 10.0 nM 10.1021/np200140j
Homo sapiens HL-60 IC50 80.0 nM 10.1016/j.bmcl.2021.128066
Homo sapiens HL-60 IC50 320.0 nM 10.1016/j.ejmech.2014.05.084
Homo sapiens HL-60 IC50 930.0 nM 10.1021/np070208z
Homo sapiens HL-60 IC50 930.0 nM 10.1021/np0704708
Homo sapiens HL-60 IC50 3800.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens HL-60 IC50 5000.0 nM 10.1016/j.bmcl.2006.07.020
Homo sapiens HL-60 IC50 5000.0 nM 10.1016/j.bmcl.2013.07.032
Homo sapiens HL-60 Imax 96.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens HL-60 LC50 4.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens HL-60 Ratio IC50 1000.0 None 10.1021/jm200764t
Homo sapiens HL-60(TB) GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HL-60(TB) GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity nan None 10.1002/hep.27206
Homo sapiens Homo sapiens Assembly 100.0 % 10.1021/jm00036a009
Homo sapiens Homo sapiens Assembly 100.0 % 10.1021/jm00107a042
Homo sapiens Homo sapiens AUC 12603.86 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens CL 6.4 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.64 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 4270.0 nM 10.1002/hep.27206
Homo sapiens Homo sapiens Css 14.76 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 4.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fabs 6.0 % 10.1124/dmd.110.034629
Homo sapiens HOP-18 GI50 157.4 nM None
Homo sapiens HOP-62 GI 26.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens HOP-62 GI 37.0 % 10.1007/s00044-010-9410-6
Homo sapiens HOP-62 GI 42.0 % 10.1016/j.bmcl.2010.01.147
Homo sapiens HOP-62 GI50 12.88 nM None
Homo sapiens HOP-62 GI50 15.85 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens HOP-62 GI50 19.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HOP-62 GI50 19.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HOP-62 GI50 67.1 nM 10.1021/np50103a016
Homo sapiens HOP-62 IC50 12.76 nM 10.6019/CHEMBL1201861
Homo sapiens HOP-62 LC50 1000.0 nM 10.1021/np50103a016
Homo sapiens HOP-62 TGI 1000.0 nM 10.1021/np50103a016
Homo sapiens HOP-92 GI50 25.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HOP-92 GI50 25.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HOP-92 GI50 73.79 nM None
Homo sapiens HOS Effective dose nan None 10.1021/jm020548b
Homo sapiens Hs-578T Activity 15.0 % 10.1021/acs.jnatprod.8b00111
Homo sapiens Hs-578T Activity nan None 10.1016/j.bmcl.2018.01.053
Homo sapiens Hs-578T Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens Hs-578T GI50 3.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens Hs-578T GI50 3.0 nM 10.1021/jm061288r
Homo sapiens Hs-578T GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens Hs-578T GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens Hs-578T GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens Hs-578T GI50 5.97 nM None
Homo sapiens Hs-578T Log IC50 -8.2 nM 10.1021/jm049405a
Homo sapiens Hs-578T TGI 100.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens Hs-578T TGI 100.0 nM 10.1021/jm061288r
Homo sapiens HSC-2 IC50 100000.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens HSP60/HSP10 IC50 100000.0 nM 10.1016/j.bmcl.2019.02.028
Homo sapiens HT IC50 80.86 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1080 IC50 0.15 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens HT-1080 IC50 0.15 nM 10.1021/jm200488a
Homo sapiens HT-1080 IC50 1.2 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens HT-1080 IC50 6000.0 nM 10.1021/np400017k
Homo sapiens HT-1080 Inhibition -0.5 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 4.7 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 10.3 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 10.8 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 12.2 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 12.4 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 12.6 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 43.7 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 46.2 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 48.7 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 50.0 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 50.3 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 50.5 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 59.8 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 64.4 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 65.6 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 70.0 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 70.9 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 79.8 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 79.9 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 81.4 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 87.0 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 87.6 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 87.7 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 87.8 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Inhibition 89.2 % 10.1016/j.bmc.2006.09.024
Homo sapiens HT-1080 Log IC50 -8.8 nM 10.1021/jm049405a
Homo sapiens HT1197 Log IC50 -5.0 nM 10.1021/jm049405a
Homo sapiens HT-144 IC50 8.003 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 Activity 1.7 % 10.1016/j.ejmech.2015.11.044
Homo sapiens HT-29 Activity 2.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens HT-29 Activity 17.6 % 10.1016/j.ejmech.2015.11.044
Homo sapiens HT-29 Activity 52.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens HT-29 Activity 77.1 % 10.1016/j.ejmech.2022.114372
Homo sapiens HT-29 Activity 80.71 % 10.1016/j.ejmech.2015.11.044
Homo sapiens HT-29 Activity 94.0 % 10.1021/acs.jmedchem.0c01826
Homo sapiens HT-29 Activity nan None 10.1016/j.ejmech.2015.11.044
Homo sapiens HT-29 Activity nan None 10.1021/acs.jmedchem.0c01826
Homo sapiens HT-29 Cytotoxicity 3.5 ng ml-1 10.1021/jm00009a009
Homo sapiens HT-29 EC50 6.0 nM 10.1016/j.bmcl.2006.07.003
Homo sapiens HT-29 ED50 0.0006 uM 10.1021/np100503q
Homo sapiens HT-29 ED50 0.001 uM 10.1021/np3007588
Homo sapiens HT-29 ED50 0.006 uM 10.1021/np200557e
Homo sapiens HT-29 ED50 0.1 nM 10.1021/np1002065
Homo sapiens HT-29 ED50 0.1 nM 10.1021/np100422z
Homo sapiens HT-29 ED50 0.1 nM 10.1021/np200051j
Homo sapiens HT-29 GI 88.36 % 10.1016/j.bmc.2013.11.037
Homo sapiens HT-29 GI50 1.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens HT-29 GI50 2.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens HT-29 GI50 2.0 nM 10.1021/jm061288r
Homo sapiens HT-29 GI50 2.512 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens HT-29 GI50 2.729 nM None
Homo sapiens HT-29 GI50 3.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens HT-29 GI50 3.0 nM 10.1016/j.ejmech.2013.06.001
Homo sapiens HT-29 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens HT-29 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens HT-29 GI50 5.3 nM 10.1039/C2MD20089A
Homo sapiens HT-29 GI50 12.0 nM 10.1021/np200041v
Homo sapiens HT-29 GI50 15.0 nM 10.1016/j.bmc.2007.04.028
Homo sapiens HT-29 GI50 15.0 nM 10.1016/j.bmc.2008.06.006
Homo sapiens HT-29 GI50 15.0 nM 10.1016/j.bmc.2008.06.028
Homo sapiens HT-29 GI50 15.0 nM 10.1016/j.bmcl.2008.05.028
Homo sapiens HT-29 IC50 0.002 ug.mL-1 10.1016/s0960-894x(98)00005-5
Homo sapiens HT-29 IC50 0.0024 ug.mL-1 10.1016/S0960-894X(01)80507-2
Homo sapiens HT-29 IC50 0.0053 ug.mL-1 10.1021/np060101w
Homo sapiens HT-29 IC50 0.0053 ug.mL-1 10.1021/np0703186
Homo sapiens HT-29 IC50 0.01 ug.mL-1 10.1021/jm020119d
Homo sapiens HT-29 IC50 0.03 ug.mL-1 10.1016/j.bmc.2007.03.041
Homo sapiens HT-29 IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens HT-29 IC50 0.16 nM 10.1021/jm010974h
Homo sapiens HT-29 IC50 0.6 nM 10.1021/np400567c
Homo sapiens HT-29 IC50 0.8 nM 10.1016/j.bmc.2019.115301
Homo sapiens HT-29 IC50 0.8 nM 10.1016/j.bmcl.2018.12.004
Homo sapiens HT-29 IC50 0.8 nM 10.1021/acs.jnatprod.5b00532
Homo sapiens HT-29 IC50 0.8 nM 10.1021/acs.jnatprod.6b00924
Homo sapiens HT-29 IC50 0.8 nM 10.1021/acs.jnatprod.7b01079
Homo sapiens HT-29 IC50 0.8 nM 10.1021/acs.jnatprod.9b01060
Homo sapiens HT-29 IC50 1.0 nM 10.1021/acs.jnatprod.9b00340
Homo sapiens HT-29 IC50 1.0 nM 10.1021/np3007414
Homo sapiens HT-29 IC50 1.0 nM 10.1021/np5002785
Homo sapiens HT-29 IC50 1.4 nM 10.1021/acs.jnatprod.6b01069
Homo sapiens HT-29 IC50 1.4 nM 10.1021/np100153m
Homo sapiens HT-29 IC50 1.9 nM 10.1021/np700717s
Homo sapiens HT-29 IC50 1.98 nM 10.1016/j.bmcl.2013.04.081
Homo sapiens HT-29 IC50 2.0 nM 10.1021/acs.jnatprod.9b00140
Homo sapiens HT-29 IC50 3.0 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens HT-29 IC50 3.0 nM 10.1021/np200076t
Homo sapiens HT-29 IC50 3.04 nM 10.1021/acs.jnatprod.5b00650
Homo sapiens HT-29 IC50 3.2 nM 10.1016/S0960-894X(01)80298-5
Homo sapiens HT-29 IC50 3.2 nM 10.1016/S0960-894X(01)80568-0
Homo sapiens HT-29 IC50 3.2 nM 10.1021/jm00036a004
Homo sapiens HT-29 IC50 3.2 nM 10.1021/jm960563e
Homo sapiens HT-29 IC50 3.2 nM 10.1021/jm9606711
Homo sapiens HT-29 IC50 3.4 nM 10.1021/np900126r
Homo sapiens HT-29 IC50 3.6 nM 10.1016/S0960-894X(96)00595-1
Homo sapiens HT-29 IC50 3.6 nM 10.1021/jm9604080
Homo sapiens HT-29 IC50 3.6 nM 10.1021/np800559z
Homo sapiens HT-29 IC50 3.6 nM 10.1021/np8006556
Homo sapiens HT-29 IC50 3.8 nM 10.1016/j.bmcl.2021.128355
Homo sapiens HT-29 IC50 3.94 nM 10.1021/np2004038
Homo sapiens HT-29 IC50 5.0 nM 10.1039/C1MD00155H
Homo sapiens HT-29 IC50 6.0 nM 10.1021/np200879p
Homo sapiens HT-29 IC50 6.1 nM 10.1021/jm101388d
Homo sapiens HT-29 IC50 7.0 nM 10.1021/jm501599u
Homo sapiens HT-29 IC50 7.0 nM 10.1021/np1008015
Homo sapiens HT-29 IC50 7.47 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens HT-29 IC50 8.0 nM 10.1016/j.bmc.2018.10.040
Homo sapiens HT-29 IC50 8.0 nM 10.1021/jm3013097
Homo sapiens HT-29 IC50 8.6 nM 10.1016/j.ejmech.2020.113050
Homo sapiens HT-29 IC50 9.0 nM 10.1016/j.bmc.2018.07.025
Homo sapiens HT-29 IC50 10.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens HT-29 IC50 10.8 nM 10.1021/acs.jmedchem.2c01595
Homo sapiens HT-29 IC50 11.0 nM 10.1016/j.bmc.2018.03.033
Homo sapiens HT-29 IC50 11.0 nM 10.1016/j.ejmech.2022.114372
Homo sapiens HT-29 IC50 14.0 nM 10.1021/acsmedchemlett.7b00189
Homo sapiens HT-29 IC50 15.0 nM 10.1021/acsmedchemlett.7b00189
Homo sapiens HT-29 IC50 25.0 nM 10.1016/j.ejmech.2017.03.055
Homo sapiens HT-29 IC50 50.0 nM 10.1021/jm0510676
Homo sapiens HT-29 IC50 50.0 nM 10.1021/jm070534b
Homo sapiens HT-29 IC50 70.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens HT-29 IC50 280.0 nM 10.1039/D1MD00125F
Homo sapiens HT-29 IC50 290.0 nM 10.1016/j.ejmech.2014.05.084
Homo sapiens HT-29 IC50 380.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens HT-29 IC50 380.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens HT-29 IC50 380.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens HT-29 IC50 450.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens HT-29 IC50 3500.0 nM 10.1021/np500583z
Homo sapiens HT-29 IC50 10000.0 nM 10.1016/j.bmc.2011.05.017
Homo sapiens HT-29 IC50 10000.0 nM 10.1016/j.bmcl.2012.02.009
Homo sapiens HT-29 IC50 10000.0 nM 10.1021/np400809w
Homo sapiens HT-29 IC50 14560.0 nM 10.1016/j.bmcl.2019.01.038
Homo sapiens HT-29 Imax 75.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens HT-29 Inhibition 3.2 % 10.1016/s0960-894x(99)00161-4
Homo sapiens HT-29 Inhibition 76.0 % 10.1016/j.bmcl.2007.10.011
Homo sapiens HT-29 LC50 4.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens HT-29 LC50 79430.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens HT-29 LC50 79430.0 nM 10.1016/j.ejmech.2013.06.001
Homo sapiens HT-29 Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens HT-29 Ratio IC50 0.93 None 10.1021/acsmedchemlett.7b00189
Homo sapiens HT-29 TGI 30.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens HT-29 TGI 200.0 nM 10.1016/j.ejmech.2013.06.001
Homo sapiens HT-29 TGI 251.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens HT-29 TGI 251.0 nM 10.1021/jm061288r
Homo sapiens HT-29 TGI 79430.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens Huh-7 Activity 50.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens Huh-7 GI50 7.41 nM 10.1016/j.ejmech.2020.113022
Homo sapiens Huh-7 GI50 206.7 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens Huh-7 IC50 2.0 nM 10.1016/j.ejmech.2020.112323
Homo sapiens Huh-7 IC50 5.0 nM 10.1021/acs.jnatprod.0c00064
Homo sapiens Huh-7 IC50 7.35 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens Huh-7 IC50 8.0 nM 10.1016/j.bmc.2009.07.051
Homo sapiens Huh-7 IC50 12.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens Huh-7 IC50 13.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens Huh-7 IC50 6750.0 nM 10.1016/j.bmcl.2016.09.002
Homo sapiens HuTu80 IC50 1.682 nM 10.6019/CHEMBL1201861
Homo sapiens HUVEC Activity nan None 10.1016/j.bmcl.2020.127291
Homo sapiens HUVEC Activity nan None 10.1016/j.ejmech.2020.113068
Homo sapiens HUVEC Activity nan None 10.1021/jm901763f
Homo sapiens HUVEC Activity nan None 10.1021/np070477p
Homo sapiens HUVEC Activity nan None None
Homo sapiens HUVEC ED50 105.0 nM 10.1021/np0304417
Homo sapiens HUVEC GI50 1.48 nM 10.1016/j.bmc.2015.09.036
Homo sapiens HUVEC GI50 10.0 ug.mL-1 10.1021/acs.jmedchem.0c01833
Homo sapiens HUVEC IC50 0.3 ug.mL-1 10.1016/j.bmcl.2005.12.009
Homo sapiens HUVEC IC50 1.3 nM 10.1016/j.ejmech.2019.112022
Homo sapiens HUVEC IC50 5.0 nM 10.1016/j.ejmech.2020.113068
Homo sapiens HUVEC IC50 7.0 nM 10.1016/j.bmc.2013.08.020
Homo sapiens HUVEC IC50 7.0 nM 10.1021/jm900016t
Homo sapiens HUVEC IC50 50.0 nM 10.1016/j.bmc.2008.11.050
Homo sapiens HUVEC IC50 50.0 nM 10.1021/acs.jmedchem.2c00608
Homo sapiens HUVEC IC50 60.0 nM 10.1016/j.bmcl.2006.06.007
Homo sapiens HUVEC IC50 71.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens HUVEC IC50 100.0 nM 10.1016/j.bmc.2008.11.050
Homo sapiens HUVEC IC50 1650.0 nM 10.1016/j.bmc.2008.11.050
Homo sapiens HUVEC IC50 5140.0 nM 10.1021/jm8006257
Homo sapiens HUVEC IC50 9390.0 nM 10.1016/j.ejmech.2019.03.031
Homo sapiens HUVEC IC50 10000.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens HUVEC IC50 nan None 10.1016/j.bmcl.2005.12.009
Homo sapiens HUVEC IC50 nan None 10.1016/j.ejmech.2010.01.051
Homo sapiens HUVEC IC50 nan None 10.1016/j.ejmech.2010.09.061
Homo sapiens HUVEC Selectivity Index 1160.0 None 10.1021/jm8006257
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 15848.9 nM None
Homo sapiens IA-LM IC50 2.802 nM 10.6019/CHEMBL1201861
Homo sapiens IGROV-1 Activity 13.0 % 10.1016/j.bmc.2011.01.039
Homo sapiens IGROV-1 Activity nan None 10.1021/jm301058f
Homo sapiens IGROV-1 GI 15.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens IGROV-1 GI 37.0 % 10.1007/s00044-010-9410-6
Homo sapiens IGROV-1 GI 43.0 % 10.1016/j.bmcl.2010.01.147
Homo sapiens IGROV-1 GI 56.0 % 10.1016/j.bmcl.2009.10.097
Homo sapiens IGROV-1 GI 66.0 % 10.1007/s00044-011-9887-7
Homo sapiens IGROV-1 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens IGROV-1 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens IGROV-1 GI50 7.079 nM None
Homo sapiens IGROV-1 IC50 0.01 ug.mL-1 10.1021/jm0009078
Homo sapiens IGROV-1 IC50 2.2 nM 10.1021/jm301058f
Homo sapiens IGROV-1 IC50 23.0 nM 10.1021/jm301058f
Homo sapiens IGROV-1 IC50 60.0 nM 10.1016/j.bmcl.2009.09.075
Homo sapiens IM-9 IC50 23697.87 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-32 GI 30.0 % 10.1007/s00044-012-0106-y
Homo sapiens IMR-32 GI 45.0 % 10.1016/j.ejmech.2009.11.001
Homo sapiens IMR-32 GI 46.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens IMR-32 GI 58.0 % 10.1016/j.ejmech.2009.10.042
Homo sapiens IMR-32 GI50 10.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens IMR-32 IC50 30.0 nM 10.1007/s00044-011-9824-9
Homo sapiens IMR-5 IC50 4.496 nM 10.6019/CHEMBL1201861
Homo sapiens Integrin alpha-V/beta-3 IC50 34.0 nM 10.1021/jm049165z
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Ishikawa GI50 nan None 10.1016/j.bmcl.2011.09.069
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 7.3 nM None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 183.6 nM None
Homo sapiens IST-MEL1 IC50 26.23 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 79.12 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 30.42 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 42.75 nM 10.6019/CHEMBL1201861
Homo sapiens J82 Activity 29.1 % 10.1016/j.bmc.2019.115044
Homo sapiens J82 Activity 35.1 % 10.1016/j.bmc.2019.115044
Homo sapiens JAR IC50 29.46 nM 10.6019/CHEMBL1201861
Homo sapiens JIMT-1 TGI 73.0 % 10.1021/acs.jmedchem.8b00961
Homo sapiens JIYOYE IC50 21.76 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 23.83 nM 10.6019/CHEMBL1201861
Homo sapiens Jurkat Activity nan None 10.1021/jm701499n
Homo sapiens Jurkat GI50 10.0 nM 10.1021/jm060968r
Homo sapiens Jurkat IC50 0.5 nM 10.1016/j.ejmech.2015.11.009
Homo sapiens Jurkat IC50 4.5 nM 10.1016/j.ejmech.2014.05.009
Homo sapiens Jurkat IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens Jurkat IC50 10.0 nM 10.1021/jm100659v
Homo sapiens Jurkat IC50 690.0 nM 10.1039/C4MD00573B
Homo sapiens Jurkat Imax 97.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens Jurkat LC50 5.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens JVM-2 IC50 1421.77 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 20898.45 nM 10.6019/CHEMBL1201861
Homo sapiens K052 IC50 32.47 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 72.26 nM 10.6019/CHEMBL1201861
Homo sapiens K562 Activity 11.0 % 10.1021/jm049876x
Homo sapiens K562 Activity 18.0 % 10.1021/jm049876x
Homo sapiens K562 Activity 57.7 % 10.1021/jm034148f
Homo sapiens K562 Activity 69.0 % None
Homo sapiens K562 Activity 71.0 % 10.1021/jm049876x
Homo sapiens K562 Activity nan None 10.1016/j.ejmech.2011.02.063
Homo sapiens K562 Activity nan None 10.1021/acs.jmedchem.7b00679
Homo sapiens K562 EC50 14.0 nM 10.1016/j.bmcl.2006.07.003
Homo sapiens K562 EC50 54.0 nM 10.1021/jm0307685
Homo sapiens K562 GI50 0.01 ug.mL-1 10.1021/np040062t
Homo sapiens K562 GI50 0.01 ug.mL-1 10.1021/np060587g
Homo sapiens K562 GI50 3.243 nM None
Homo sapiens K562 GI50 4.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens K562 GI50 4.85 nM 10.1016/j.ejmech.2020.113022
Homo sapiens K562 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens K562 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens K562 GI50 7.014 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens K562 GI50 100.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens K562 IC50 0.018 ug.mL-1 10.1016/j.ejmech.2014.10.013
Homo sapiens K562 IC50 0.6 nM 10.1016/j.bmc.2008.02.029
Homo sapiens K562 IC50 0.71 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens K562 IC50 0.71 nM 10.1021/jm200488a
Homo sapiens K562 IC50 3.0 nM 10.1016/j.bmcl.2020.127168
Homo sapiens K562 IC50 3.3 nM 10.1016/j.ejmech.2019.111587
Homo sapiens K562 IC50 4.0 nM 10.1016/j.bmcl.2014.07.035
Homo sapiens K562 IC50 4.9 nM 10.1021/np300897v
Homo sapiens K562 IC50 5.1 nM 10.1021/jm301581y
Homo sapiens K562 IC50 5.2 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens K562 IC50 5.5 nM 10.1016/j.ejmech.2014.05.009
Homo sapiens K562 IC50 7.0 nM 10.1021/jm301581y
Homo sapiens K562 IC50 7.17 nM 10.1021/acs.jnatprod.5b00650
Homo sapiens K562 IC50 7.2 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens K562 IC50 15.16 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 15.7 nM 10.1021/jm301864s
Homo sapiens K562 IC50 29.6 nM 10.1021/acs.jmedchem.2c01595
Homo sapiens K562 IC50 290.0 nM 10.1039/D1MD00125F
Homo sapiens K562 IC50 380.0 nM 10.1016/j.bmcl.2016.07.059
Homo sapiens K562 IC50 410.0 nM 10.1016/j.ejmech.2012.03.024
Homo sapiens K562 IC50 410.0 nM 10.1016/j.ejmech.2012.11.002
Homo sapiens K562 IC50 410.0 nM 10.1016/j.ejmech.2013.04.012
Homo sapiens K562 IC50 900.0 nM 10.1021/acs.jnatprod.5b00331
Homo sapiens K562 IC50 1160.0 nM 10.1016/j.bmc.2009.03.037
Homo sapiens K562 IC50 1160.0 nM 10.1016/j.bmc.2010.10.047
Homo sapiens K562 IC50 1160.0 nM 10.1016/j.ejmech.2009.09.017
Homo sapiens K562 IC50 1160.0 nM 10.1016/j.ejmech.2011.01.057
Homo sapiens K562 IC50 1260.0 nM 10.1039/C4MD00573B
Homo sapiens K562 IC50 2400.0 nM 10.1021/np500583z
Homo sapiens K562 IC50 2700.0 nM 10.1021/acs.jnatprod.6b00561
Homo sapiens K562 IC50 3210.0 nM 10.1016/j.bmcl.2016.09.002
Homo sapiens K562 IC50 3650.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens K562 IC50 3800.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens K562 IC50 4140.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens K562 IC50 5630.0 nM 10.1016/j.bmc.2009.03.037
Homo sapiens K562 IC50 5630.0 nM 10.1016/j.ejmech.2011.01.057
Homo sapiens K562 IC50 5800.0 nM 10.1016/j.ejmech.2019.03.031
Homo sapiens K562 IC50 100000.0 nM 10.1007/s00044-012-0436-9
Homo sapiens K562 IC50 6900000.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens K562 IC50 nan None 10.1016/j.ejmech.2018.11.070
Homo sapiens K562 IC50 nan None 10.1016/j.ejmech.2021.113316
Homo sapiens K562 Imax 94.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens K562 LC50 8.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens K562 LC50 100000.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens K562 Ratio IC50 91.0 None 10.1021/jm200764t
Homo sapiens K562 TGI 100.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens K562 TGI 15850.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens K562 TGI nan None 10.1021/acs.jmedchem.7b00679
Homo sapiens K562/VCR IC50 nan None 10.1016/j.ejmech.2018.11.070
Homo sapiens K562/VCR IC50 nan None 10.1016/j.ejmech.2021.113316
Homo sapiens KALS-1 IC50 3.08 nM 10.6019/CHEMBL1201861
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KARPAS-299 IC50 39.8 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 56.5 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 12.7 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 4.0 nM 10.1021/acs.jmedchem.1c01123
Homo sapiens Kasumi 1 IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens Kasumi 1 IC50 23511.93 nM 10.6019/CHEMBL1201861
Homo sapiens KB Activity 15.0 % 10.1016/j.ejmech.2017.09.016
Homo sapiens KB Activity 31.0 % 10.1021/np50022a019
Homo sapiens KB Activity nan None 10.1021/jm4011115
Homo sapiens KB Activity nan None 10.1021/np010322w
Homo sapiens KB EC50 0.005 ug.mL-1 10.1016/j.bmcl.2008.06.099
Homo sapiens KB EC50 0.005 ug.mL-1 10.1021/np800622a
Homo sapiens KB EC50 2.0 nM 10.1021/jm101388d
Homo sapiens KB EC50 6.0 nM 10.1016/j.bmcl.2011.11.026
Homo sapiens KB EC50 760.0 nM 10.1016/j.bmcl.2011.11.026
Homo sapiens KB ED50 0.001 ug ml-1 10.1021/jm020548b
Homo sapiens KB ED50 0.001 ug ml-1 10.1021/np030241v
Homo sapiens KB ED50 0.002 ug ml-1 10.1016/j.bmcl.2007.06.083
Homo sapiens KB ED50 0.007 uM 10.1021/np100406d
Homo sapiens KB ED50 0.023 uM 10.1021/np800767a
Homo sapiens KB ED50 0.4 nM 10.1021/np0304417
Homo sapiens KB ED50 1.0 10'-5 ug/ml 10.1021/np50046a018
Homo sapiens KB ED50 1.0 10'-5 ug/ml 10.1021/np50056a017
Homo sapiens KB ED50 1.2 10'-3 ug/ml 10.1021/np50015a013
Homo sapiens KB ED50 1.8 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens KB ED50 2.0 10'-2 ug/ml 10.1021/np960079e
Homo sapiens KB ED50 2.0 10'-2 ug/ml 10.1021/np9606660
Homo sapiens KB ED50 2.87 nM 10.1016/j.bmc.2011.01.001
Homo sapiens KB ED50 8.9 ug ml-1 10.1021/np50022a010
Homo sapiens KB Effective dose nan None 10.1021/jm020548b
Homo sapiens KB FC 1.0 None 10.1021/np000595b
Homo sapiens KB FC 15.0 None 10.1021/np000595b
Homo sapiens KB GI 20.0 % 10.1021/np800767a
Homo sapiens KB GI 70.0 % 10.1021/np800767a
Homo sapiens KB GI nan None 10.1016/j.bmc.2015.12.042
Homo sapiens KB GI50 1.0 nM 10.1016/j.bmc.2015.12.042
Homo sapiens KB GI50 2.65 nM 10.1016/j.bmcl.2012.08.014
Homo sapiens KB GI50 4.1 nM 10.1021/acsmedchemlett.9b00352
Homo sapiens KB GI50 4.12 nM 10.1016/j.ejmech.2011.12.025
Homo sapiens KB GI50 4.6 nM 10.1021/acsmedchemlett.1c00505
Homo sapiens KB GI50 4.87 nM 10.1016/j.bmc.2011.01.034
Homo sapiens KB GI50 5.12 nM 10.1021/acs.jmedchem.7b00273
Homo sapiens KB GI50 5.16 nM 10.1016/j.bmc.2011.02.004
Homo sapiens KB GI50 6.4 nM 10.1016/j.bmc.2015.07.016
Homo sapiens KB GI50 6.4 nM 10.1016/j.bmcl.2015.02.018
Homo sapiens KB GI50 6.4 nM 10.1016/j.ejmech.2013.06.041
Homo sapiens KB GI50 6.4 nM 10.1021/jm4016526
Homo sapiens KB GI50 7.77 nM 10.1016/j.bmc.2012.11.047
Homo sapiens KB GI50 8.0 nM 10.1016/j.bmc.2013.11.018
Homo sapiens KB GI50 948000.0 nM 10.1016/j.bmc.2016.05.025
Homo sapiens KB IC50 0.001 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens KB IC50 0.001 ug.mL-1 10.1021/np0202273
Homo sapiens KB IC50 0.0013 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens KB IC50 0.0015 ug.mL-1 10.1021/np030346y
Homo sapiens KB IC50 0.0016 ug.mL-1 10.1016/j.bmcl.2012.04.084
Homo sapiens KB IC50 0.002 ug.mL-1 10.1021/np900620y
Homo sapiens KB IC50 0.0048 ug.mL-1 10.1016/j.bmcl.2011.12.024
Homo sapiens KB IC50 0.04 nM 10.1016/j.bmcl.2015.09.010
Homo sapiens KB IC50 0.085 ug.mL-1 10.1021/np900620y
Homo sapiens KB IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens KB IC50 0.1 ug.mL-1 10.1021/np010071r
Homo sapiens KB IC50 0.8 nM 10.1021/acs.jnatprod.6b00645
Homo sapiens KB IC50 1.0 nM 10.1021/np0500575
Homo sapiens KB IC50 1.55 nM 10.1016/j.bmcl.2009.12.041
Homo sapiens KB IC50 1.9 nM 10.1016/j.ejmech.2017.06.001
Homo sapiens KB IC50 2.45 nM 10.1016/j.bmcl.2007.03.070
Homo sapiens KB IC50 2.45 nM 10.1021/jm060717i
Homo sapiens KB IC50 2.5 nM 10.1016/j.bmc.2008.11.016
Homo sapiens KB IC50 3.3 nM 10.1016/j.bmc.2014.06.042
Homo sapiens KB IC50 3.3 nM 10.1021/jm201031f
Homo sapiens KB IC50 3.3 nM 10.1021/jm8008635
Homo sapiens KB IC50 3.6 nM 10.1021/acs.jnatprod.6b01099
Homo sapiens KB IC50 3.6 nM 10.1021/acs.jnatprod.7b00949
Homo sapiens KB IC50 3.7 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens KB IC50 3.9 nM 10.1016/j.bmcl.2014.03.091
Homo sapiens KB IC50 3.9 nM 10.1016/j.bmcl.2014.06.060
Homo sapiens KB IC50 3.9 nM 10.1016/j.bmcl.2014.09.065
Homo sapiens KB IC50 4.1 nM 10.1021/jm4011115
Homo sapiens KB IC50 4.2 nM 10.1016/j.bmc.2008.02.012
Homo sapiens KB IC50 4.5 nM 10.1021/np200741x
Homo sapiens KB IC50 5.1 nM 10.1016/j.bmc.2015.06.043
Homo sapiens KB IC50 5.1 nM 10.1016/j.ejmech.2014.02.061
Homo sapiens KB IC50 5.71 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens KB IC50 5.79 nM 10.1016/j.ejmech.2021.113578
Homo sapiens KB IC50 5.9 nM 10.1016/j.bmcl.2017.04.055
Homo sapiens KB IC50 6.0 nM 10.1021/np0000872
Homo sapiens KB IC50 6.1 nM 10.1016/j.bmc.2019.05.016
Homo sapiens KB IC50 6.27 nM 10.1021/acs.jnatprod.6b01153
Homo sapiens KB IC50 6.3 nM 10.1021/acs.jnatprod.6b01151
Homo sapiens KB IC50 6.6 nM 10.1021/acs.jnatprod.7b00578
Homo sapiens KB IC50 6.69 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens KB IC50 6.72 nM 10.1016/j.ejmech.2019.111696
Homo sapiens KB IC50 6.8 nM 10.1021/acs.jnatprod.8b00211
Homo sapiens KB IC50 7.4 nM 10.1021/acs.jnatprod.9b00596
Homo sapiens KB IC50 7.7 nM 10.1021/acs.jnatprod.0c00454
Homo sapiens KB IC50 7.9 nM 10.1021/jm8008635
Homo sapiens KB IC50 8.0 nM 10.1016/j.bmcl.2021.128319
Homo sapiens KB IC50 8.21 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens KB IC50 9.1 nM 10.1016/s0960-894x(02)00118-x
Homo sapiens KB IC50 10.0 nM 10.1016/j.ejmech.2019.111584
Homo sapiens KB IC50 10.0 nM 10.1021/jm0307685
Homo sapiens KB IC50 10.3 nM 10.1016/j.ejmech.2018.07.029
Homo sapiens KB IC50 15.0 nM 10.1016/j.bmc.2015.02.004
Homo sapiens KB IC50 20.0 nM 10.1016/j.bmc.2009.10.019
Homo sapiens KB IC50 20.0 nM 10.1021/np010322w
Homo sapiens KB IC50 80.0 nM 10.1016/j.bmcl.2004.05.077
Homo sapiens KB IC50 80.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens KB IC50 80.0 nM 10.1016/j.ejmech.2009.12.060
Homo sapiens KB IC50 80.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens KB IC50 80.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens KB IC50 273.0 nM 10.1021/jm8008635
Homo sapiens KB IC50 626.0 nM 10.1016/s0960-894x(00)00555-2
Homo sapiens KB IC50 1700.0 nM 10.1016/s0960-894x(02)00118-x
Homo sapiens KB IC50 2540.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens KB IC50 3800.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens KB IC50 3800.0 nM 10.1021/np500583z
Homo sapiens KB IC50 5900.0 nM 10.1016/j.ejmech.2018.08.069
Homo sapiens KB IC50 6587.0 nM 10.1016/j.ejmech.2017.02.025
Homo sapiens KB IC50 6600.0 nM 10.1021/acs.jnatprod.9b00659
Homo sapiens KB IC50 6684.0 nM 10.1016/j.bmcl.2011.06.036
Homo sapiens KB IC50 7520.0 nM 10.1039/C7MD00310B
Homo sapiens KB IC50 16500.0 nM 10.1021/jm8008635
Homo sapiens KB IC90 0.047 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens KB IC90 0.048 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens KB Inhibition 19.5 % 10.1021/np010322w
Homo sapiens KB Inhibition 70.2 % 10.1021/np010322w
Homo sapiens KB Ratio IC50 10.0 None 10.1016/j.bmc.2008.11.016
Homo sapiens KB Ratio IC50 11.0 None 10.1016/j.bmcl.2007.03.070
Homo sapiens KB Ratio IC50 11.0 None 10.1021/jm060717i
Homo sapiens KB 3-1 IC50 0.5 nM 10.1016/j.ejmech.2018.02.045
Homo sapiens KB 3-1 IC50 2.1 nM 10.1016/j.bmcl.2005.03.038
Homo sapiens KB 3-1 IC50 2.92 nM 10.1016/s0960-894x(00)00555-2
Homo sapiens KB 3-1 IC50 3.9 nM 10.1021/jm040056u
Homo sapiens KB 3-1 IC50 6.0 nM 10.1016/j.bmcl.2004.05.077
Homo sapiens KB 3-1 IC50 600.0 nM 10.1016/j.bmcl.2005.03.038
Homo sapiens KB 3-1 IC50 3000.0 nM 10.1016/j.bmcl.2004.05.077
Homo sapiens KB 3-1 IC50 400000.0 nM 10.1016/j.bmc.2008.02.029
Homo sapiens KB-V1 IC50 9800.0 nM 10.1016/j.ejmech.2017.06.001
Homo sapiens KE-37 IC50 12.34 nM 10.6019/CHEMBL1201861
Homo sapiens KETR3 IC50 50.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens KG-1 IC50 28286.48 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 Imax 89.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens KG-1 LC50 70.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens KGN IC50 7.124 nM 10.6019/CHEMBL1201861
Homo sapiens Kinesin-like protein KIF20A IC50 nan None 10.1016/j.bmc.2015.12.042
Homo sapiens Kinesin-like protein KIF20A Imax nan None 10.1016/j.bmc.2015.12.042
Homo sapiens KINGS-1 IC50 23.55 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 104.43 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 GI50 3.062 nM None
Homo sapiens KM12 GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens KM12 GI50 4.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens KM12 GI50 4.0 nM 10.1021/jm061288r
Homo sapiens KM12 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens KM12 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens KM12 IC50 6.373 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 TGI 15850.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens KM12 TGI 15850.0 nM 10.1021/jm061288r
Homo sapiens KM-20L2 GI50 2.812 nM None
Homo sapiens KM-H2 IC50 33.07 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 2757.12 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 1904.81 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 8.907 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 229.58 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-RT-BM-1 IC50 223.49 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 122.91 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 5.816 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 20.39 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 7.478 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 26.97 nM 10.6019/CHEMBL1201861
Homo sapiens L02 GI50 30.8 nM 10.1021/acs.jmedchem.0c01345
Homo sapiens L02 IC50 2.0 nM 10.1016/j.ejmech.2017.03.055
Homo sapiens L02 IC50 100.0 nM 10.1016/j.ejmech.2021.113685
Homo sapiens L02 IC50 540.0 nM 10.1016/j.ejmech.2022.114439
Homo sapiens L02 IC50 5600.0 nM 10.1021/acs.jmedchem.8b01424
Homo sapiens L02 IC50 6100.0 nM 10.1021/acs.jmedchem.2c00077
Homo sapiens L02 IC50 79670.0 nM 10.1016/j.bmcl.2021.128503
Homo sapiens L02 IC50 100000.0 nM 10.1021/acs.jnatprod.0c00698
Homo sapiens L2987 IC50 200.0 nM 10.1016/j.bmc.2007.03.041
Homo sapiens L-363 IC50 13.51 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 169.45 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 46.39 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 129.9 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 3547.88 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 25.1 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 10038.58 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 81.41 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 41.05 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 10.51 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 25.34 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 24.85 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 77.07 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 437.65 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 0.3167 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 43.51 nM 10.6019/CHEMBL1201861
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens LNCaP Activity 7.08 % 10.1016/j.ejmech.2019.07.039
Homo sapiens LNCaP Activity 92.9 % 10.1016/j.ejmech.2019.07.039
Homo sapiens LNCaP Activity nan None 10.1016/j.ejmech.2019.07.039
Homo sapiens LNCaP CC50 1.4 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens LNCaP ED50 2.6 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens LNCaP ED50 5.0 nM 10.1021/np0304417
Homo sapiens LNCaP ED50 10.0 uM 10.1016/j.bmc.2008.10.076
Homo sapiens LNCaP IC50 1.7 ug.mL-1 10.1016/j.bmc.2014.04.025
Homo sapiens LNCaP IC50 1.9 nM 10.1021/acs.jmedchem.7b00958
Homo sapiens LNCaP IC50 2.0 nM 10.1021/jm049208b
Homo sapiens LNCaP IC50 20.0 nM 10.1021/np010322w
Homo sapiens LNCaP IC50 22.3 nM 10.1021/jm100729b
Homo sapiens LNCaP IC50 6320.0 nM 10.1021/np900225p
Homo sapiens LNCaP IC50 20960.0 nM 10.1016/j.ejmech.2019.01.076
Homo sapiens LNCaP Log IC50 -5.0 nM 10.1021/jm049405a
Homo sapiens LNCaP-Clone-FGC IC50 6344.89 nM 10.6019/CHEMBL1201861
Homo sapiens LOUCY IC50 7.75 nM 10.6019/CHEMBL1201861
Homo sapiens LoVo IC50 90.0 nM 10.1016/j.bmc.2007.03.041
Homo sapiens LoVo IC50 nan None 10.1016/j.ejmech.2011.10.013
Homo sapiens LoVo IC50 nan None 10.1021/jm200392p
Homo sapiens LoVo Log IC50 -7.3 nM 10.1021/jm049405a
Homo sapiens LOX IMVI GI50 3.548 nM None
Homo sapiens LOX IMVI GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens LOX IMVI GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens LOX IMVI GI50 16.0 nM 10.1021/jm400479p
Homo sapiens LOX IMVI IC50 17.3 nM 10.1021/jm040056u
Homo sapiens LOX IMVI IC50 70.28 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 IC50 280.57 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 80.35 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 16.64 nM 10.6019/CHEMBL1201861
Homo sapiens LS174T IC50 9.5 nM 10.1021/acs.jmedchem.7b00958
Homo sapiens LS180 IC50 2.8 nM 10.1021/acs.jnatprod.6b00873
Homo sapiens LS-411N IC50 7.166 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 493.07 nM 10.6019/CHEMBL1201861
Homo sapiens Lu1 ED50 2.0 nM 10.1021/np0304417
Homo sapiens Lu1 ED50 10.0 uM 10.1016/j.bmc.2008.10.076
Homo sapiens Lu1 IC50 10.0 nM 10.1021/np010322w
Homo sapiens LU-134-A IC50 47.73 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 59.86 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 3019.56 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 133.07 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-99 cell line IC50 0.002 ug.mL-1 10.1016/S0960-894X(97)00071-1
Homo sapiens LXF-289 cell line IC50 8.184 nM 10.6019/CHEMBL1201861
Homo sapiens LXFL 529 GI50 528.45 nM None
Homo sapiens M14 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens M14 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens M14 GI50 10.0 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens M14 GI50 22.91 nM None
Homo sapiens M14 IC50 0.5 nM 10.1021/acs.jmedchem.1c00715
Homo sapiens M14 IC50 1.3 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens M14 IC50 1.3 nM 10.1021/acs.jmedchem.9b01815
Homo sapiens M14 IC50 7.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens M14 IC50 186.3 nM 10.1021/acs.jmedchem.1c00715
Homo sapiens M19-MEL GI50 3.083 nM None
Homo sapiens M19-MEL IC50 0.003 ug.mL-1 10.1021/jm0009078
Homo sapiens M21 Activity nan None 10.1016/j.bmc.2008.06.006
Homo sapiens M21 Activity nan None 10.1016/j.bmc.2008.06.028
Homo sapiens M21 GI50 37.0 nM 10.1016/j.bmc.2007.04.028
Homo sapiens M21 GI50 37.0 nM 10.1016/j.bmc.2008.06.006
Homo sapiens M21 GI50 37.0 nM 10.1016/j.bmc.2008.06.028
Homo sapiens M21 GI50 37.0 nM 10.1016/j.bmcl.2008.05.028
Homo sapiens Malme-3M GI50 29.04 nM None
Homo sapiens Malme-3M GI50 50.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens Malme-3M GI50 50.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens Malme-3M Log IC50 -6.0 nM 10.1021/jm049405a
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 Delta TM 0.57 C 10.6019/CHEMBL5308504
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MC116 IC50 2.888 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 23.26 nM 10.6019/CHEMBL1201861
Homo sapiens MCF-10A IC50 5.8 nM 10.1021/acs.jnatprod.7b00500
Homo sapiens MCF-10A IC50 10000.0 nM 10.1021/acs.jmedchem.2c00608
Homo sapiens MCF-10A IC50 427000.0 nM 10.1016/j.ejmech.2013.07.018
Homo sapiens MCF7 Activity 1.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens MCF7 Activity 1.65 % 10.1021/np200866z
Homo sapiens MCF7 Activity 1.71 % 10.1021/np200866z
Homo sapiens MCF7 Activity 2.91 % 10.1021/np200866z
Homo sapiens MCF7 Activity 3.43 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MCF7 Activity 7.07 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MCF7 Activity 9.0 % 10.1016/j.bmc.2008.06.028
Homo sapiens MCF7 Activity 9.0 % 10.1016/j.bmcl.2008.05.028
Homo sapiens MCF7 Activity 9.0 % 10.1016/j.bmcl.2014.11.083
Homo sapiens MCF7 Activity 9.34 % 10.1021/np200866z
Homo sapiens MCF7 Activity 10.0 % 10.1016/j.bmcl.2014.11.083
Homo sapiens MCF7 Activity 10.0 % 10.1021/acs.jnatprod.8b00964
Homo sapiens MCF7 Activity 11.0 % 10.1016/j.bmc.2008.06.028
Homo sapiens MCF7 Activity 11.0 % 10.1016/j.bmcl.2008.05.028
Homo sapiens MCF7 Activity 15.6 % 10.1021/np200866z
Homo sapiens MCF7 Activity 18.5 % 10.1016/j.ejmech.2010.11.011
Homo sapiens MCF7 Activity 19.01 % 10.1016/j.ejmech.2010.11.011
Homo sapiens MCF7 Activity 20.0 % 10.1021/np030296x
Homo sapiens MCF7 Activity 30.0 % 10.1016/j.bmcl.2008.05.002
Homo sapiens MCF7 Activity 38.0 % 10.1016/j.bmcl.2014.11.083
Homo sapiens MCF7 Activity 43.0 % 10.1016/j.bmcl.2014.11.083
Homo sapiens MCF7 Activity 43.0 % 10.1016/j.ejmech.2007.10.025
Homo sapiens MCF7 Activity 43.0 % 10.1016/j.ejmech.2011.05.047
Homo sapiens MCF7 Activity 50.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens MCF7 Activity 62.48 % 10.1016/j.ejmech.2010.11.011
Homo sapiens MCF7 Activity 65.7 % 10.1016/j.ejmech.2020.113050
Homo sapiens MCF7 Activity 70.0 % 10.1021/np030296x
Homo sapiens MCF7 Activity 72.1 % 10.1021/np200866z
Homo sapiens MCF7 Activity 75.7 % 10.1016/j.ejmech.2020.113050
Homo sapiens MCF7 Activity 80.0 % 10.1016/j.bmc.2008.06.028
Homo sapiens MCF7 Activity 80.0 % 10.1016/j.bmcl.2008.05.028
Homo sapiens MCF7 Activity 84.2 % 10.1021/acs.jmedchem.1c01099
Homo sapiens MCF7 Activity 86.54 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MCF7 Activity nan None 10.1016/j.bmc.2019.02.002
Homo sapiens MCF7 Activity nan None 10.1016/j.bmc.2019.02.046
Homo sapiens MCF7 Activity nan None 10.1016/j.ejmech.2011.05.046
Homo sapiens MCF7 Activity nan None 10.1016/j.ejmech.2016.11.037
Homo sapiens MCF7 Activity nan None 10.1016/j.ejmech.2020.113050
Homo sapiens MCF7 Activity nan None 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens MCF7 Activity nan None 10.1021/np050397q
Homo sapiens MCF7 Activity nan None 10.1021/np200866z
Homo sapiens MCF7 CC50 20.0 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens MCF7 EC50 0.0072 ug.mL-1 10.1016/j.bmcl.2008.06.099
Homo sapiens MCF7 EC50 0.0072 ug.mL-1 10.1021/np800622a
Homo sapiens MCF7 EC50 36.0 nM 10.1016/j.bmcl.2006.07.003
Homo sapiens MCF7 EC50 194.2 nM 10.1016/j.bmcl.2021.127923
Homo sapiens MCF7 EC50 2065.8 nM 10.1016/j.bmcl.2021.127923
Homo sapiens MCF7 EC50 44720.0 nM 10.1016/j.bmcl.2022.128731
Homo sapiens MCF7 ED50 0.05 ug ml-1 10.1016/j.bmc.2007.03.041
Homo sapiens MCF7 ED50 1.1 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens MCF7 ED50 2.1 nM 10.1016/j.bmcl.2008.10.010
Homo sapiens MCF7 ED50 3.2 nM 10.1016/j.bmcl.2008.09.103
Homo sapiens MCF7 ED50 3.23 nM 10.1016/j.bmcl.2005.10.063
Homo sapiens MCF7 ED50 4.0 nM 10.1021/jm001103v
Homo sapiens MCF7 ED50 10.0 uM 10.1016/j.bmc.2008.10.076
Homo sapiens MCF7 ED50 100.0 nM 10.1016/j.bmc.2011.01.001
Homo sapiens MCF7 ED50 nan None 10.1021/np030241v
Homo sapiens MCF7 Effective dose nan None 10.1021/jm020548b
Homo sapiens MCF7 GI 65.0 % 10.1016/j.ejmech.2009.10.042
Homo sapiens MCF7 GI 80.0 % 10.1007/s00044-012-0404-4
Homo sapiens MCF7 GI 86.7 % 10.1021/np400002p
Homo sapiens MCF7 GI 94.2 % 10.1016/j.bmc.2013.11.037
Homo sapiens MCF7 GI nan None 10.1016/j.bmcl.2013.11.032
Homo sapiens MCF7 GI50 0.0021 ug.mL-1 10.1021/acs.jmedchem.0c01833
Homo sapiens MCF7 GI50 0.0048 ug.mL-1 10.1016/j.bmcl.2017.01.004
Homo sapiens MCF7 GI50 0.0048 ug.mL-1 10.1039/C5MD00404G
Homo sapiens MCF7 GI50 0.075 ug.mL-1 10.1016/j.bmcl.2016.02.056
Homo sapiens MCF7 GI50 1.1 nM 10.1016/s0960-894x(98)00477-6
Homo sapiens MCF7 GI50 1.1 nM 10.1016/s0960-894x(99)00276-0
Homo sapiens MCF7 GI50 1.29 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens MCF7 GI50 2.76 nM 10.1016/j.ejmech.2020.113022
Homo sapiens MCF7 GI50 2.924 nM None
Homo sapiens MCF7 GI50 3.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens MCF7 GI50 3.0 nM 10.1016/j.ejmech.2013.06.001
Homo sapiens MCF7 GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens MCF7 GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens MCF7 GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens MCF7 GI50 4.38 nM 10.1021/acs.jmedchem.6b00324
Homo sapiens MCF7 GI50 5.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens MCF7 GI50 7.1 nM 10.1021/acsmedchemlett.1c00505
Homo sapiens MCF7 GI50 8.3 nM 10.1021/acsmedchemlett.9b00352
Homo sapiens MCF7 GI50 10.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens MCF7 GI50 10.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens MCF7 GI50 11.9 nM 10.1021/acs.jmedchem.7b00273
Homo sapiens MCF7 GI50 12.0 nM 10.1021/np200041v
Homo sapiens MCF7 GI50 30.0 nM 10.1021/jm300705j
Homo sapiens MCF7 GI50 54.0 nM 10.1016/j.bmc.2007.04.028
Homo sapiens MCF7 GI50 54.0 nM 10.1016/j.bmc.2008.06.006
Homo sapiens MCF7 GI50 54.0 nM 10.1016/j.bmc.2008.06.028
Homo sapiens MCF7 GI50 54.0 nM 10.1016/j.bmcl.2008.05.028
Homo sapiens MCF7 GI50 1070.0 nM 10.1016/j.bmcl.2011.07.049
Homo sapiens MCF7 GI50 87000.0 nM 10.1039/C6MD00278A
Homo sapiens MCF7 GI90 0.0039 ug ml-1 10.1016/j.bmcl.2016.02.056
Homo sapiens MCF7 GI90 0.075 ug ml-1 10.1016/j.bmcl.2017.01.004
Homo sapiens MCF7 IC50 0.0001 ug.mL-1 10.1021/jm020119d
Homo sapiens MCF7 IC50 0.00125 ug.mL-1 10.1016/j.bmcl.2004.10.097
Homo sapiens MCF7 IC50 0.003 ug.mL-1 10.1016/j.bmc.2007.03.041
Homo sapiens MCF7 IC50 0.003 ug.mL-1 10.1021/jm0009078
Homo sapiens MCF7 IC50 0.005 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens MCF7 IC50 0.008 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens MCF7 IC50 0.01 ug.mL-1 10.1016/j.ejmech.2014.10.013
Homo sapiens MCF7 IC50 0.015 ug.mL-1 10.1016/j.ejmech.2021.113511
Homo sapiens MCF7 IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens MCF7 IC50 0.14 ug.mL-1 10.1021/np050082a
Homo sapiens MCF7 IC50 0.2 nM 10.1021/acs.jnatprod.8b01084
Homo sapiens MCF7 IC50 0.5 nM 10.1016/j.bmcl.2006.11.008
Homo sapiens MCF7 IC50 0.5 nM 10.1016/s0960-894x(02)00694-7
Homo sapiens MCF7 IC50 0.6 nM 10.1016/j.bmcl.2005.08.066
Homo sapiens MCF7 IC50 0.61 ug.mL-1 10.1016/j.ejmech.2014.03.021
Homo sapiens MCF7 IC50 0.91 nM 10.1021/jm200692n
Homo sapiens MCF7 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens MCF7 IC50 1.2 nM 10.1021/np8006556
Homo sapiens MCF7 IC50 1.25 nM 10.1016/j.bmcl.2016.06.012
Homo sapiens MCF7 IC50 1.4 nM 10.1021/np0303456
Homo sapiens MCF7 IC50 1.5 nM 10.1021/np5003498
Homo sapiens MCF7 IC50 1.62 nM 10.1021/ml1003074
Homo sapiens MCF7 IC50 1.7 nM 10.1016/j.bmc.2014.05.048
Homo sapiens MCF7 IC50 1.7 nM 10.1016/j.bmcl.2004.05.027
Homo sapiens MCF7 IC50 1.7 nM 10.1016/S0960-894X(01)80298-5
Homo sapiens MCF7 IC50 1.7 nM 10.1016/S0960-894X(01)80568-0
Homo sapiens MCF7 IC50 1.7 nM 10.1016/S0960-894X(96)00595-1
Homo sapiens MCF7 IC50 1.7 nM 10.1016/s0960-894x(99)00629-0
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm00036a004
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm025540g
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm034146v
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm800086e
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm9604080
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm960563e
Homo sapiens MCF7 IC50 1.7 nM 10.1021/jm9606711
Homo sapiens MCF7 IC50 1.8 nM 10.1016/j.bmc.2007.05.070
Homo sapiens MCF7 IC50 1.9 nM 10.1021/jm050996u
Homo sapiens MCF7 IC50 2.0 nM 10.1016/j.bmc.2010.07.069
Homo sapiens MCF7 IC50 2.0 nM 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 IC50 2.0 nM 10.1021/np0004449
Homo sapiens MCF7 IC50 2.0 nM 10.1021/np900207z
Homo sapiens MCF7 IC50 2.4 nM 10.1021/acs.jnatprod.7b01006
Homo sapiens MCF7 IC50 2.5 nM 10.1016/j.bmc.2011.05.030
Homo sapiens MCF7 IC50 2.5 nM 10.1016/j.ejmech.2020.112609
Homo sapiens MCF7 IC50 2.5 nM 10.1021/jm070194u
Homo sapiens MCF7 IC50 2.87 nM 10.1016/s0960-894x(02)00694-7
Homo sapiens MCF7 IC50 3.0 nM 10.1016/j.bmc.2013.08.020
Homo sapiens MCF7 IC50 3.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens MCF7 IC50 3.0 nM 10.1016/j.bmcl.2011.12.074
Homo sapiens MCF7 IC50 3.0 nM 10.1016/j.bmcl.2015.01.056
Homo sapiens MCF7 IC50 3.0 nM 10.1016/j.bmcl.2020.127168
Homo sapiens MCF7 IC50 3.0 nM 10.1021/jm900016t
Homo sapiens MCF7 IC50 3.0 nM 10.1021/jm900476c
Homo sapiens MCF7 IC50 3.0 nM 10.1021/np3003639
Homo sapiens MCF7 IC50 3.1 nM 10.1016/j.bmcl.2016.06.012
Homo sapiens MCF7 IC50 3.3 nM 10.1016/j.ejmech.2019.111587
Homo sapiens MCF7 IC50 3.9 nM 10.1016/j.bmcl.2015.09.010
Homo sapiens MCF7 IC50 4.0 nM 10.1016/j.ejmech.2014.07.035
Homo sapiens MCF7 IC50 4.0 nM 10.1016/j.ejmech.2020.112519
Homo sapiens MCF7 IC50 4.4 nM 10.1016/j.bmcl.2010.07.100
Homo sapiens MCF7 IC50 4.7 ug.mL-1 10.1039/d2md00192f
Homo sapiens MCF7 IC50 4.9 nM 10.1016/j.bmc.2007.03.041
Homo sapiens MCF7 IC50 4.9 nM 10.1016/S0960-894X(97)10152-4
Homo sapiens MCF7 IC50 4.9 nM 10.1021/np030296x
Homo sapiens MCF7 IC50 5.0 nM 10.1016/j.bmcl.2018.04.018
Homo sapiens MCF7 IC50 5.0 nM 10.1016/j.ejmech.2013.03.029
Homo sapiens MCF7 IC50 5.0 nM 10.1016/j.ejmech.2014.07.035
Homo sapiens MCF7 IC50 5.0 nM 10.1021/np300897v
Homo sapiens MCF7 IC50 5.5 nM 10.1016/j.ejmech.2018.04.042
Homo sapiens MCF7 IC50 5.5 nM 10.1016/s0960-894x(02)00118-x
Homo sapiens MCF7 IC50 6.0 nM 10.1016/j.bmc.2012.02.057
Homo sapiens MCF7 IC50 6.0 nM 10.1016/j.bmcl.2008.06.039
Homo sapiens MCF7 IC50 6.0 nM 10.1021/np1008015
Homo sapiens MCF7 IC50 6.1 nM 10.1039/d1md00392e
Homo sapiens MCF7 IC50 6.2 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens MCF7 IC50 6.5 nM 10.1021/acs.jnatprod.7b01006
Homo sapiens MCF7 IC50 6.6 nM 10.1016/j.ejmech.2020.113050
Homo sapiens MCF7 IC50 7.0 nM 10.1021/jm0510676
Homo sapiens MCF7 IC50 7.0 nM 10.1021/jm070534b
Homo sapiens MCF7 IC50 7.05 nM 10.1016/j.bmc.2013.11.037
Homo sapiens MCF7 IC50 7.3 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens MCF7 IC50 7.32 nM 10.1021/acs.jnatprod.5b00650
Homo sapiens MCF7 IC50 7.4 nM 10.1021/acs.jnatprod.5b00774
Homo sapiens MCF7 IC50 7.52 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens MCF7 IC50 8.0 nM 10.1016/j.bmcl.2018.05.038
Homo sapiens MCF7 IC50 8.0 nM 10.1016/j.ejmech.2019.02.025
Homo sapiens MCF7 IC50 8.0 nM 10.1016/j.ejmech.2021.113629
Homo sapiens MCF7 IC50 8.0 nM 10.1016/j.ejmech.2022.114844
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.0c00298
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.1c00342
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.5b00057
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.6b00508
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.7b00150
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.7b00163
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.7b00514
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.7b00723
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.7b00909
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.9b00022
Homo sapiens MCF7 IC50 8.0 nM 10.1021/acs.jnatprod.9b00183
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np200140j
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np300772e
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np400041y
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np400190n
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np400287r
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np4005823
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np400600c
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np400669t
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np4010135
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np5005196
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np500626x
Homo sapiens MCF7 IC50 8.0 nM 10.1021/np501057f
Homo sapiens MCF7 IC50 8.37 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens MCF7 IC50 8.54 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens MCF7 IC50 8.8 nM 10.1021/acs.jnatprod.7b00500
Homo sapiens MCF7 IC50 8.8 nM 10.1021/acs.jnatprod.7b00949
Homo sapiens MCF7 IC50 9.6 nM 10.1016/j.ejmech.2018.07.029
Homo sapiens MCF7 IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens MCF7 IC50 10.4 nM 10.1021/acs.jnatprod.6b01151
Homo sapiens MCF7 IC50 10.4 nM 10.1021/acs.jnatprod.6b01153
Homo sapiens MCF7 IC50 11.2 nM 10.1016/j.bmc.2019.05.016
Homo sapiens MCF7 IC50 11.2 nM 10.1021/acs.jnatprod.8b00211
Homo sapiens MCF7 IC50 11.2 nM 10.1021/np030266u
Homo sapiens MCF7 IC50 11.2 nM 10.1021/np030353m
Homo sapiens MCF7 IC50 11.4 nM 10.1021/acs.jnatprod.7b00578
Homo sapiens MCF7 IC50 11.46 nM 10.1016/j.bmcl.2017.04.055
Homo sapiens MCF7 IC50 11.7 nM 10.1021/np0704957
Homo sapiens MCF7 IC50 12.0 nM 10.1016/j.ejmech.2022.114372
Homo sapiens MCF7 IC50 12.0 nM 10.1021/acs.jmedchem.6b00021
Homo sapiens MCF7 IC50 12.06 nM 10.1016/j.ejmech.2019.111696
Homo sapiens MCF7 IC50 12.4 nM 10.1021/acs.jmedchem.6b00071
Homo sapiens MCF7 IC50 12.4 nM 10.1021/np070256j
Homo sapiens MCF7 IC50 13.5 nM 10.1021/acs.jnatprod.0c00454
Homo sapiens MCF7 IC50 14.0 nM 10.1021/np200431k
Homo sapiens MCF7 IC50 14.0 nM 10.1021/np5009569
Homo sapiens MCF7 IC50 15.0 nM 10.1016/j.bmc.2019.02.046
Homo sapiens MCF7 IC50 15.0 nM 10.1016/j.bmcl.2006.02.035
Homo sapiens MCF7 IC50 15.0 nM 10.1016/j.bmcl.2012.06.055
Homo sapiens MCF7 IC50 15.0 nM 10.1016/j.bmcl.2021.128319
Homo sapiens MCF7 IC50 19.0 nM 10.1021/jm050920y
Homo sapiens MCF7 IC50 19.7 nM 10.1021/acs.jmedchem.2c01595
Homo sapiens MCF7 IC50 20.0 nM 10.1021/np010322w
Homo sapiens MCF7 IC50 20.5 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens MCF7 IC50 20.5 nM 10.1016/j.ejmech.2013.10.033
Homo sapiens MCF7 IC50 21.0 nM 10.1016/j.ejmech.2010.01.051
Homo sapiens MCF7 IC50 21.0 nM 10.1016/j.ejmech.2010.09.061
Homo sapiens MCF7 IC50 22.75 nM 10.1021/acs.jnatprod.6b00645
Homo sapiens MCF7 IC50 23.0 nM 10.1021/jm500024v
Homo sapiens MCF7 IC50 25.81 nM 10.1016/j.ejmech.2014.05.043
Homo sapiens MCF7 IC50 25.81 nM 10.1016/j.ejmech.2016.03.029
Homo sapiens MCF7 IC50 30.0 nM 10.1016/j.bmc.2021.116442
Homo sapiens MCF7 IC50 32.0 nM 10.1016/j.bmcl.2021.128503
Homo sapiens MCF7 IC50 32.0 nM 10.1016/j.ejmech.2015.02.031
Homo sapiens MCF7 IC50 32.3 nM 10.1021/acs.jmedchem.1c02159
Homo sapiens MCF7 IC50 32.3 nM 10.1021/acs.jmedchem.6b00158
Homo sapiens MCF7 IC50 35.7 nM 10.1021/acs.jmedchem.2c00608
Homo sapiens MCF7 IC50 39.0 nM 10.1016/j.bmcl.2008.10.077
Homo sapiens MCF7 IC50 40.0 nM 10.1016/s0960-894x(02)01002-8
Homo sapiens MCF7 IC50 43.0 nM 10.1016/j.bmcl.2006.02.035
Homo sapiens MCF7 IC50 45.0 nM 10.1016/j.ejmech.2014.06.002
Homo sapiens MCF7 IC50 50.0 nM 10.1021/acs.jnatprod.8b00677
Homo sapiens MCF7 IC50 63.3 nM 10.1016/j.ejmech.2021.113578
Homo sapiens MCF7 IC50 80.0 nM 10.1016/j.bmc.2009.05.006
Homo sapiens MCF7 IC50 81.1 nM 10.1016/j.bmc.2021.116551
Homo sapiens MCF7 IC50 90.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens MCF7 IC50 100.0 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens MCF7 IC50 100.0 nM 10.1016/j.bmcl.2016.07.025
Homo sapiens MCF7 IC50 100.0 nM 10.1021/acs.jnatprod.6b00306
Homo sapiens MCF7 IC50 100.0 nM 10.1021/np200866z
Homo sapiens MCF7 IC50 100.0 nM 10.1021/np400070x
Homo sapiens MCF7 IC50 100.0 nM 10.1021/np400379u
Homo sapiens MCF7 IC50 100.0 nM 10.1021/np4004068
Homo sapiens MCF7 IC50 100.0 nM 10.1021/np800484j
Homo sapiens MCF7 IC50 100.0 nM 10.1021/np9000366
Homo sapiens MCF7 IC50 132.0 nM 10.1021/jm500849z
Homo sapiens MCF7 IC50 200.0 nM 10.1016/j.bmcl.2014.08.010
Homo sapiens MCF7 IC50 299.0 nM 10.1021/jm00036a004
Homo sapiens MCF7 IC50 299.0 nM 10.1021/jm9604080
Homo sapiens MCF7 IC50 300.0 nM 10.1016/S0960-894X(01)80298-5
Homo sapiens MCF7 IC50 300.0 nM 10.1016/s0960-894x(99)00629-0
Homo sapiens MCF7 IC50 300.0 nM 10.1021/np8006556
Homo sapiens MCF7 IC50 330.0 nM 10.1016/j.ejmech.2014.05.084
Homo sapiens MCF7 IC50 350.0 nM 10.1039/D1MD00125F
Homo sapiens MCF7 IC50 354.0 nM 10.1021/np0303456
Homo sapiens MCF7 IC50 420.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 IC50 470.0 nM 10.1016/j.ejmech.2019.01.005
Homo sapiens MCF7 IC50 480.0 nM 10.1016/j.bmc.2021.116252
Homo sapiens MCF7 IC50 480.0 nM 10.1016/j.bmc.2023.117188
Homo sapiens MCF7 IC50 500.0 nM 10.1016/j.ejmech.2013.08.017
Homo sapiens MCF7 IC50 560.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 IC50 570.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 IC50 630.0 nM 10.1016/j.ejmech.2010.11.014
Homo sapiens MCF7 IC50 630.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 IC50 640.0 nM 10.1016/j.ejmech.2022.114439
Homo sapiens MCF7 IC50 660.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens MCF7 IC50 800.0 nM 10.1016/j.bmcl.2004.09.025
Homo sapiens MCF7 IC50 900.0 nM 10.1021/np3002173
Homo sapiens MCF7 IC50 1170.0 nM 10.1016/j.ejmech.2019.03.031
Homo sapiens MCF7 IC50 1300.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens MCF7 IC50 1300.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens MCF7 IC50 1300.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens MCF7 IC50 1428.0 nM 10.1016/j.bmc.2017.09.019
Homo sapiens MCF7 IC50 1800.0 nM 10.1021/np500382k
Homo sapiens MCF7 IC50 1860.0 nM 10.1007/s00044-012-0436-9
Homo sapiens MCF7 IC50 2100.0 nM 10.1021/acs.jnatprod.0c01012
Homo sapiens MCF7 IC50 2110.0 nM 10.1016/j.bmc.2009.03.037
Homo sapiens MCF7 IC50 2110.0 nM 10.1016/j.bmc.2010.10.047
Homo sapiens MCF7 IC50 2110.0 nM 10.1016/j.ejmech.2011.01.057
Homo sapiens MCF7 IC50 2290.87 nM 10.1021/acs.jnatprod.7b01012
Homo sapiens MCF7 IC50 2300.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens MCF7 IC50 2580.0 nM 10.1016/j.bmcl.2014.11.083
Homo sapiens MCF7 IC50 2980.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens MCF7 IC50 3100.0 nM 10.1021/np400614f
Homo sapiens MCF7 IC50 3200.0 nM 10.1021/np500583z
Homo sapiens MCF7 IC50 3990.0 nM 10.1016/j.bmc.2015.11.007
Homo sapiens MCF7 IC50 4770.0 nM 10.1016/j.ejmech.2012.03.024
Homo sapiens MCF7 IC50 5100.0 nM 10.1021/acs.jnatprod.0c00698
Homo sapiens MCF7 IC50 6000.0 nM 10.1016/s0960-894x(02)00118-x
Homo sapiens MCF7 IC50 7600.0 nM 10.1021/jm500024v
Homo sapiens MCF7 IC50 8200.0 nM 10.1016/j.bmc.2007.05.070
Homo sapiens MCF7 IC50 9660.0 nM 10.1039/C4MD00573B
Homo sapiens MCF7 IC50 10000.0 nM 10.1021/acs.jnatprod.9b00659
Homo sapiens MCF7 IC50 11400.0 nM 10.1016/j.ejmech.2017.02.025
Homo sapiens MCF7 IC50 11500.0 nM 10.1016/j.ejmech.2018.08.069
Homo sapiens MCF7 IC50 13990.0 nM 10.1039/C6MD00234J
Homo sapiens MCF7 IC50 29000.0 nM 10.1021/np900722j
Homo sapiens MCF7 IC50 40000.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens MCF7 IC50 40370.0 nM 10.1016/j.bmc.2019.02.044
Homo sapiens MCF7 IC50 71000.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 IC50 75200.0 nM 10.1016/j.ejmech.2013.07.018
Homo sapiens MCF7 IC50 77200.0 nM 10.1016/j.ejmech.2012.12.022
Homo sapiens MCF7 IC50 90000.0 nM 10.1021/acs.jmedchem.1c00404
Homo sapiens MCF7 IC50 4420000.0 nM 10.1021/acs.jmedchem.5b00058
Homo sapiens MCF7 IC50 nan None 10.1016/j.bmc.2010.01.061
Homo sapiens MCF7 IC50 nan None 10.1016/j.bmcl.2015.04.051
Homo sapiens MCF7 IC50 nan None 10.1016/j.bmcl.2021.128066
Homo sapiens MCF7 IC50 nan None 10.1016/j.ejmech.2009.04.022
Homo sapiens MCF7 IC50 nan None 10.1021/acs.jnatprod.6b01069
Homo sapiens MCF7 IC50 nan None 10.1021/np500836y
Homo sapiens MCF7 IC90 0.85 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens MCF7 IC90 0.86 ug.mL-1 10.1016/j.ejmech.2007.09.002
Homo sapiens MCF7 IC90 15.0 nM 10.1021/jm050996u
Homo sapiens MCF7 IC90 107.0 ug.mL-1 10.1021/np400002p
Homo sapiens MCF7 Imax 79.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens MCF7 Inhibition 1.7 % 10.1016/s0960-894x(99)00161-4
Homo sapiens MCF7 Inhibition 46.0 % 10.1016/j.bmcl.2007.10.011
Homo sapiens MCF7 Inhibition nan % 10.1016/j.ejmech.2019.111954
Homo sapiens MCF7 LC50 3.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens MCF7 LC50 100000.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens MCF7 LC50 100000.0 nM 10.1016/j.ejmech.2013.06.001
Homo sapiens MCF7 LD50 29.0 uM 10.1016/j.bmcl.2019.08.019
Homo sapiens MCF7 Ratio 1.0 None 10.1016/s0960-894x(00)00031-7
Homo sapiens MCF7 Ratio 1.0 None 10.1016/s0960-894x(03)00054-4
Homo sapiens MCF7 Ratio 112.0 None 10.1016/s0960-894x(99)00629-0
Homo sapiens MCF7 Ratio 176.0 None 10.1021/np8006556
Homo sapiens MCF7 Ratio 177.0 None 10.1016/s0960-894x(99)00629-0
Homo sapiens MCF7 Ratio ED50 1.0 None 10.1016/j.bmcl.2008.09.103
Homo sapiens MCF7 Ratio IC50 1.1 None 10.1016/j.bmc.2011.05.030
Homo sapiens MCF7 Ratio IC50 2.3 None 10.1016/j.bmc.2013.08.020
Homo sapiens MCF7 Ratio IC50 2.3 None 10.1021/jm900016t
Homo sapiens MCF7 Ratio IC50 7.0 None 10.1021/jm900016t
Homo sapiens MCF7 Ratio IC50 11.3 None 10.1021/acs.jmedchem.6b00021
Homo sapiens MCF7 Ratio IC50 13.0 None 10.1021/jm900016t
Homo sapiens MCF7 Ratio IC50 38.0 None None
Homo sapiens MCF7 Ratio IC50 176.0 None 10.1016/j.bmc.2014.05.048
Homo sapiens MCF7 Ratio IC50 176.0 None 10.1021/jm800086e
Homo sapiens MCF7 Ratio IC50 1080.0 None 10.1016/j.bmc.2011.05.030
Homo sapiens MCF7 Ratio IC50 2525.0 None 10.1021/jm500024v
Homo sapiens MCF7 Ratio IC50 25000.0 None 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 TGI 59.2 % 10.1021/acs.jmedchem.6b00158
Homo sapiens MCF7 TGI 60.0 % 10.1016/j.ejmech.2020.112670
Homo sapiens MCF7 TGI 400.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens MCF7 TGI 100000.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens MCF7 TGI 100000.0 nM 10.1016/j.ejmech.2013.06.001
Homo sapiens MCF7 TGI nan None 10.1016/j.bmcl.2021.127923
Homo sapiens MCF7-DOX IC50 585.0 nM 10.1016/j.bmcl.2005.08.066
Homo sapiens MCF7/PTX Activity 1.3 % 10.1016/j.ejmech.2019.03.031
Homo sapiens MCF7/PTX Activity 1.5 % 10.1016/j.ejmech.2019.03.031
Homo sapiens MCF7/PTX Activity 3.9 % 10.1016/j.ejmech.2019.03.031
Homo sapiens MCF7/PTX Activity 15.0 % 10.1021/acs.jnatprod.8b00964
Homo sapiens MCF7/PTX Activity 93.2 % 10.1016/j.ejmech.2019.03.031
Homo sapiens MCF7/PTX IC50 54800.0 nM 10.1016/j.ejmech.2019.03.031
Homo sapiens MCF7R IC50 190.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens MCF7R IC50 299.0 nM 10.1016/S0960-894X(96)00595-1
Homo sapiens MCF7R IC50 299.0 nM 10.1021/jm034146v
Homo sapiens MCF7R IC50 299.0 nM 10.1021/jm960563e
Homo sapiens MCF7R IC50 299.0 nM 10.1021/jm9606711
Homo sapiens MCF7R IC50 550.0 nM 10.1016/j.bmcl.2005.10.089
Homo sapiens MCF7R IC50 860.0 nM 10.1016/s0960-894x(97)10218-9
Homo sapiens MCF7R IC50 1185.0 nM 10.1016/j.bmcl.2004.04.060
Homo sapiens MCF7R Inhibition 300.0 % 10.1016/s0960-894x(99)00161-4
Homo sapiens MCF7R Reduction 0.0 % 10.1016/s0960-894x(97)10218-9
Homo sapiens MCF7S IC50 1.7 nM 10.1016/j.bmcl.2005.10.089
Homo sapiens MCF7S IC50 2.0 nM 10.1016/j.bmcl.2004.04.060
Homo sapiens MDA-MB-134-VI IC50 369.28 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-157 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens MDA-MB-231 Activity 0.0 % 10.1016/j.ejmech.2010.11.011
Homo sapiens MDA-MB-231 Activity 3.95 % 10.1016/j.ejmech.2011.10.036
Homo sapiens MDA-MB-231 Activity 7.9 day 10.1021/jm800979v
Homo sapiens MDA-MB-231 Activity 11.93 % 10.1016/j.ejmech.2011.10.036
Homo sapiens MDA-MB-231 Activity 17.23 % 10.1016/j.ejmech.2011.10.036
Homo sapiens MDA-MB-231 Activity 19.0 day 10.1021/jm800979v
Homo sapiens MDA-MB-231 Activity 19.7 uM 10.1016/j.ejmech.2022.114832
Homo sapiens MDA-MB-231 Activity 31.0 % 10.1021/jm800979v
Homo sapiens MDA-MB-231 Activity 36.0 % 10.1016/j.ejmech.2020.112181
Homo sapiens MDA-MB-231 Activity 54.3 % 10.1021/acs.jmedchem.8b00672
Homo sapiens MDA-MB-231 Activity 60.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens MDA-MB-231 Activity 100.0 % 10.1016/j.ejmech.2010.11.011
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.ejmech.2019.111954
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.0c01477
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.0c01826
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.1c00404
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.6b00943
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jmedchem.8b00672
Homo sapiens MDA-MB-231 Activity nan None 10.1021/jm1000858
Homo sapiens MDA-MB-231 GI nan None 10.1021/acs.jnatprod.6b00924
Homo sapiens MDA-MB-231 GI50 5.2 nM 10.1021/acsmedchemlett.9b00352
Homo sapiens MDA-MB-231 GI50 7.4 nM 10.1021/acsmedchemlett.1c00505
Homo sapiens MDA-MB-231 GI50 8.67 nM 10.1021/acs.jmedchem.6b00324
Homo sapiens MDA-MB-231 GI50 10.0 nM 10.1016/j.bmcl.2015.03.032
Homo sapiens MDA-MB-231 GI50 10.0 nM 10.1016/j.ejmech.2016.02.059
Homo sapiens MDA-MB-231 GI50 10.0 nM 10.1021/acs.jmedchem.7b00273
Homo sapiens MDA-MB-231 GI50 12.5 nM 10.1016/j.bmc.2018.04.010
Homo sapiens MDA-MB-231 GI50 12.5 nM 10.1016/j.bmc.2020.115887
Homo sapiens MDA-MB-231 GI50 16.0 nM 10.1016/j.ejmech.2019.111700
Homo sapiens MDA-MB-231 GI50 53.95 nM None
Homo sapiens MDA-MB-231 GI50 91.0 nM 10.1016/j.bmcl.2014.09.018
Homo sapiens MDA-MB-231 GI50 91.0 nM 10.1016/j.bmcl.2016.05.021
Homo sapiens MDA-MB-231 GI50 91.0 nM 10.1016/j.ejmech.2014.10.051
Homo sapiens MDA-MB-231 GI50 91.2 nM 10.1016/j.bmcl.2016.05.021
Homo sapiens MDA-MB-231 GI50 220.0 nM 10.1016/j.ejmech.2022.114441
Homo sapiens MDA-MB-231 GI50 300.0 nM 10.1016/j.ejmech.2022.114441
Homo sapiens MDA-MB-231 IC50 0.12 ug.mL-1 10.1021/np050082a
Homo sapiens MDA-MB-231 IC50 0.2 nM 10.1021/acs.jnatprod.0c00856
Homo sapiens MDA-MB-231 IC50 0.6 nM 10.1021/acs.jnatprod.2c01048
Homo sapiens MDA-MB-231 IC50 0.6 nM 10.1021/acsmedchemlett.1c00024
Homo sapiens MDA-MB-231 IC50 0.8 nM 10.1021/acs.jmedchem.1c00715
Homo sapiens MDA-MB-231 IC50 1.0 nM 10.1016/j.ejmech.2015.09.019
Homo sapiens MDA-MB-231 IC50 1.0 nM 10.1016/j.ejmech.2021.113337
Homo sapiens MDA-MB-231 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens MDA-MB-231 IC50 1.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens MDA-MB-231 IC50 2.6 nM 10.1021/acs.jnatprod.6b01175
Homo sapiens MDA-MB-231 IC50 2.6 nM 10.1021/acs.jnatprod.8b00432
Homo sapiens MDA-MB-231 IC50 2.7 nM 10.1021/acs.jnatprod.6b00924
Homo sapiens MDA-MB-231 IC50 2.7 nM 10.1021/acs.jnatprod.9b01060
Homo sapiens MDA-MB-231 IC50 2.8 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens MDA-MB-231 IC50 3.0 nM 10.1016/j.ejmech.2017.12.004
Homo sapiens MDA-MB-231 IC50 3.0 nM 10.1016/j.ejmech.2020.112323
Homo sapiens MDA-MB-231 IC50 3.0 nM 10.1016/j.ejmech.2022.114112
Homo sapiens MDA-MB-231 IC50 3.0 nM 10.1021/acs.jnatprod.0c00064
Homo sapiens MDA-MB-231 IC50 3.0 nM 10.1021/acs.jnatprod.6b00873
Homo sapiens MDA-MB-231 IC50 3.05 nM 10.1021/acs.jnatprod.6b00645
Homo sapiens MDA-MB-231 IC50 3.1 nM 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-231 IC50 3.388 nM 10.1016/j.bmcl.2016.05.023
Homo sapiens MDA-MB-231 IC50 3.42 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens MDA-MB-231 IC50 3.9 nM 10.1021/acs.jnatprod.5b00774
Homo sapiens MDA-MB-231 IC50 3.9 ug.mL-1 10.1021/jm800767c
Homo sapiens MDA-MB-231 IC50 4.0 nM 10.1021/acs.jmedchem.8b01445
Homo sapiens MDA-MB-231 IC50 4.5 nM 10.1016/j.bmc.2007.03.041
Homo sapiens MDA-MB-231 IC50 4.5 nM 10.1021/np030296x
Homo sapiens MDA-MB-231 IC50 5.6 nM 10.1021/jm401708f
Homo sapiens MDA-MB-231 IC50 6.6 nM 10.1016/j.bmcl.2014.06.060
Homo sapiens MDA-MB-231 IC50 7.0 nM 10.1016/j.ejmech.2022.114372
Homo sapiens MDA-MB-231 IC50 7.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens MDA-MB-231 IC50 7.0 nM 10.1021/acs.jnatprod.7b00949
Homo sapiens MDA-MB-231 IC50 7.8 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens MDA-MB-231 IC50 8.0 nM 10.1016/j.bmcl.2021.128319
Homo sapiens MDA-MB-231 IC50 8.1 nM 10.1021/acs.jnatprod.8b00211
Homo sapiens MDA-MB-231 IC50 8.2 nM 10.1021/np5003498
Homo sapiens MDA-MB-231 IC50 8.51 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens MDA-MB-231 IC50 8.6 nM 10.1021/acs.jnatprod.0c00454
Homo sapiens MDA-MB-231 IC50 8.8 nM 10.1021/acs.jnatprod.6b01151
Homo sapiens MDA-MB-231 IC50 8.82 nM 10.1021/acs.jnatprod.6b01153
Homo sapiens MDA-MB-231 IC50 9.0 nM 10.1021/acs.jnatprod.7b00189
Homo sapiens MDA-MB-231 IC50 9.1 nM 10.1016/j.bmc.2019.05.016
Homo sapiens MDA-MB-231 IC50 9.1 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens MDA-MB-231 IC50 9.1 nM 10.1021/jm200488a
Homo sapiens MDA-MB-231 IC50 9.17 nM 10.1016/j.ejmech.2021.113578
Homo sapiens MDA-MB-231 IC50 9.4 nM 10.1021/acs.jnatprod.7b00578
Homo sapiens MDA-MB-231 IC50 9.63 nM 10.1016/j.bmcl.2017.04.055
Homo sapiens MDA-MB-231 IC50 9.74 nM 10.1016/j.ejmech.2019.111696
Homo sapiens MDA-MB-231 IC50 10.0 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens MDA-MB-231 IC50 10.7 nM 10.1021/acs.jnatprod.9b00596
Homo sapiens MDA-MB-231 IC50 12.1 nM 10.1021/acs.jnatprod.8b00411
Homo sapiens MDA-MB-231 IC50 17.0 nM 10.1016/j.bmc.2018.07.025
Homo sapiens MDA-MB-231 IC50 18.0 nM 10.1016/j.bmcl.2015.09.010
Homo sapiens MDA-MB-231 IC50 19.3 nM 10.1039/d1md00392e
Homo sapiens MDA-MB-231 IC50 20.0 nM 10.1016/j.bmc.2020.115736
Homo sapiens MDA-MB-231 IC50 21.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens MDA-MB-231 IC50 25.0 nM 10.1016/j.bmcl.2020.127557
Homo sapiens MDA-MB-231 IC50 27.0 nM 10.1016/j.bmc.2021.116442
Homo sapiens MDA-MB-231 IC50 30.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens MDA-MB-231 IC50 40.0 nM 10.1016/j.bmc.2021.116442
Homo sapiens MDA-MB-231 IC50 40.5 nM 10.1016/j.bmcl.2008.06.066
Homo sapiens MDA-MB-231 IC50 47.1 nM 10.1016/j.bmcl.2008.10.077
Homo sapiens MDA-MB-231 IC50 50.0 nM 10.1016/j.ejmech.2022.114832
Homo sapiens MDA-MB-231 IC50 52.0 nM 10.1021/np300551g
Homo sapiens MDA-MB-231 IC50 59.0 nM 10.1021/acs.jnatprod.7b00500
Homo sapiens MDA-MB-231 IC50 60.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens MDA-MB-231 IC50 70.3 nM 10.1021/np0704957
Homo sapiens MDA-MB-231 IC50 80.0 nM 10.1016/j.bmcl.2017.01.080
Homo sapiens MDA-MB-231 IC50 100.0 nM 10.1016/j.bmcl.2016.07.025
Homo sapiens MDA-MB-231 IC50 100.0 nM 10.1016/j.ejmech.2020.113102
Homo sapiens MDA-MB-231 IC50 100.0 nM 10.1021/acs.jnatprod.9b00140
Homo sapiens MDA-MB-231 IC50 170.0 nM 10.1021/acs.jnatprod.9b00711
Homo sapiens MDA-MB-231 IC50 200.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens MDA-MB-231 IC50 457.0 nM 10.1016/j.ejmech.2014.10.037
Homo sapiens MDA-MB-231 IC50 900.0 nM 10.1016/j.ejmech.2020.112948
Homo sapiens MDA-MB-231 IC50 1000.0 nM 10.1021/np400235s
Homo sapiens MDA-MB-231 IC50 1600.0 nM 10.1016/j.bmc.2021.116252
Homo sapiens MDA-MB-231 IC50 2010.0 nM 10.1016/j.ejmech.2019.111954
Homo sapiens MDA-MB-231 IC50 2560.0 nM 10.1016/j.bmc.2015.11.007
Homo sapiens MDA-MB-231 IC50 3770.0 nM 10.1021/acs.jmedchem.1c01624
Homo sapiens MDA-MB-231 IC50 5000.0 nM 10.1021/np3003639
Homo sapiens MDA-MB-231 IC50 5340.0 nM 10.1039/C7MD00310B
Homo sapiens MDA-MB-231 IC50 6200.0 nM 10.1016/j.bmcl.2014.10.041
Homo sapiens MDA-MB-231 IC50 9384.0 nM 10.1016/j.ejmech.2017.02.025
Homo sapiens MDA-MB-231 IC50 9400.0 nM 10.1021/acs.jnatprod.9b00659
Homo sapiens MDA-MB-231 IC50 9600.0 nM 10.1016/j.ejmech.2018.08.069
Homo sapiens MDA-MB-231 IC50 13230.0 nM 10.1016/j.bmcl.2019.01.038
Homo sapiens MDA-MB-231 IC50 25000.0 nM 10.1021/np900722j
Homo sapiens MDA-MB-231 IC50 50000.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens MDA-MB-231 IC50 56120.0 nM 10.1016/j.bmcl.2021.128503
Homo sapiens MDA-MB-231 IC50 87000.0 nM 10.1016/j.ejmech.2013.07.018
Homo sapiens MDA-MB-231 IC50 nan None 10.1016/j.ejmech.2009.04.022
Homo sapiens MDA-MB-231 Inhibition 40.0 % 10.1016/j.ejmech.2015.09.019
Homo sapiens MDA-MB-231 Inhibition 85.0 % 10.1021/np030296x
Homo sapiens MDA-MB-231 Inhibition nan % 10.1016/j.ejmech.2019.111954
Homo sapiens MDA-MB-231 LD50 0.003 ug ml-1 10.1021/np9805084
Homo sapiens MDA-MB-231 Log IC50 -5.0 nM 10.1021/jm049405a
Homo sapiens MDA-MB-231 T/C 33.0 % 10.1021/jm800979v
Homo sapiens MDA-MB-231 TGI nan None 10.1016/j.bmc.2018.09.025
Homo sapiens MDA-MB-231 TGI nan None 10.1021/acs.jmedchem.5b00270
Homo sapiens MDA-MB-231 TGI nan None 10.1021/acs.jmedchem.8b00672
Homo sapiens MDA-MB-231 TIME 362.4 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens MDA-MB-231 TIME 626.4 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens MDA-MB-231 TIME 1656.0 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens MDA-MB-435 Activity nan None 10.1016/j.bmc.2023.117217
Homo sapiens MDA-MB-435 Activity nan None 10.1016/j.bmcl.2013.07.032
Homo sapiens MDA-MB-435 Activity nan None 10.1021/jm101655d
Homo sapiens MDA-MB-435 Activity nan None 10.1021/np9805140
Homo sapiens MDA-MB-435 EC50 4.5 nM 10.1021/acs.jmedchem.6b00237
Homo sapiens MDA-MB-435 GI 9.0 % 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 GI 27.0 % 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 GI 54.0 % 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 GI50 1.0 nM 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 GI50 1.9 nM 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 GI50 2.512 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens MDA-MB-435 GI50 3.4 nM 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 GI50 3.954 nM None
Homo sapiens MDA-MB-435 GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens MDA-MB-435 GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens MDA-MB-435 GI50 4.0 nM 10.1021/jm800271c
Homo sapiens MDA-MB-435 IC50 0.2 nM 10.1021/acs.jnatprod.6b00924
Homo sapiens MDA-MB-435 IC50 0.2 nM 10.1021/acs.jnatprod.9b01060
Homo sapiens MDA-MB-435 IC50 0.3 nM 10.1021/acs.jnatprod.2c01048
Homo sapiens MDA-MB-435 IC50 0.3 nM 10.1021/acsmedchemlett.1c00024
Homo sapiens MDA-MB-435 IC50 0.4 nM 10.1021/acs.jnatprod.0c00856
Homo sapiens MDA-MB-435 IC50 0.4 nM 10.1021/acs.jnatprod.9b00711
Homo sapiens MDA-MB-435 IC50 0.5 nM 10.1021/acs.jnatprod.7b00189
Homo sapiens MDA-MB-435 IC50 0.8 nM 10.1016/s0960-894x(01)00462-0
Homo sapiens MDA-MB-435 IC50 1.93 nM 10.1016/j.bmc.2014.04.049
Homo sapiens MDA-MB-435 IC50 2.0 nM 10.1016/j.bmc.2017.04.012
Homo sapiens MDA-MB-435 IC50 2.9 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 3.1 nM 10.1021/acs.jnatprod.6b01175
Homo sapiens MDA-MB-435 IC50 3.1 nM 10.1021/acs.jnatprod.8b00432
Homo sapiens MDA-MB-435 IC50 3.3 nM 10.1016/j.bmc.2015.03.061
Homo sapiens MDA-MB-435 IC50 4.0 nM 10.1016/j.bmcl.2004.04.060
Homo sapiens MDA-MB-435 IC50 4.0 nM 10.1021/jm4001117
Homo sapiens MDA-MB-435 IC50 4.5 nM 10.1016/j.bmc.2021.116061
Homo sapiens MDA-MB-435 IC50 4.5 nM 10.1016/j.bmc.2023.117217
Homo sapiens MDA-MB-435 IC50 4.5 nM 10.1016/j.bmcl.2018.07.039
Homo sapiens MDA-MB-435 IC50 4.8 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 5.0 nM 10.1016/j.bmcl.2006.07.020
Homo sapiens MDA-MB-435 IC50 5.2 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 13.0 nM 10.1016/j.bmc.2018.07.025
Homo sapiens MDA-MB-435 IC50 16.0 nM 10.1016/j.bmc.2011.06.084
Homo sapiens MDA-MB-435 IC50 69.3 nM 10.1021/jm100884b
Homo sapiens MDA-MB-435 IC50 105.0 nM 10.1021/jm060593+
Homo sapiens MDA-MB-435 IC50 277.0 nM 10.1021/jm100884b
Homo sapiens MDA-MB-435 IC50 379.0 nM 10.1016/j.bmcl.2004.04.060
Homo sapiens MDA-MB-435 IC50 465.0 nM 10.1016/j.bmc.2011.06.084
Homo sapiens MDA-MB-435 IC50 490.0 nM 10.1016/s0960-894x(01)00462-0
Homo sapiens MDA-MB-435 IC50 612.0 nM 10.1016/s0960-894x(01)00462-0
Homo sapiens MDA-MB-435 IC50 860.0 nM 10.1016/s0960-894x(97)10218-9
Homo sapiens MDA-MB-435 IC50 reduction 0.0 % 10.1016/s0960-894x(01)00462-0
Homo sapiens MDA-MB-435 RatioGI50 1.9 None 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 RatioGI50 3.4 None 10.1021/acs.jnatprod.6b00944
Homo sapiens MDA-MB-435 Ratio IC50 20.0 None 10.1021/jm060593+
Homo sapiens MDA-MB-435 Ratio IC50 22.0 None 10.1021/jm060593+
Homo sapiens MDA-MB-435 Ratio IC50 29.0 None 10.1016/j.bmc.2011.06.084
Homo sapiens MDA-MB-435 Reduction 0.0 % 10.1016/s0960-894x(97)10218-9
Homo sapiens MDA-MB-435 TGI nan None 10.1016/j.bmc.2017.04.012
Homo sapiens MDA-MB-435 TGI nan None 10.1021/acs.jmedchem.6b00237
Homo sapiens MDA-MB-436 Activity nan None 10.1016/j.bmcl.2018.01.053
Homo sapiens MDA-MB-453 IC50 0.7 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens MDA-MB-468 Activity 0.26 g 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-468 Activity 10.0 % 10.1021/acs.jnatprod.8b00964
Homo sapiens MDA-MB-468 Activity 15.0 % 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-468 Activity 30.0 % 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-468 Activity nan None 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-468 Activity nan None 10.1021/acs.jnatprod.8b00111
Homo sapiens MDA-MB-468 GI50 12.5 nM 10.1016/j.bmc.2018.04.010
Homo sapiens MDA-MB-468 GI50 100.0 nM 10.1016/j.ejmech.2022.114441
Homo sapiens MDA-MB-468 IC50 1.0 nM 10.1021/acs.jmedchem.1c01202
Homo sapiens MDA-MB-468 IC50 3.0 nM 10.1021/acs.jmedchem.1c00705
Homo sapiens MDA-MB-468 IC50 5.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens MDA-MB-468 IC50 5.4 nM 10.1021/acs.jmedchem.7b00958
Homo sapiens MDA-MB-468 IC50 6.1 nM 10.1021/acs.jnatprod.7b00500
Homo sapiens MDA-MB-468 IC50 7.17 nM 10.1021/np500342m
Homo sapiens MDA-MB-468 IC50 200.0 nM 10.1016/j.bmcl.2016.07.025
Homo sapiens MDA-MB-468 IC50 310.0 nM 10.1039/C4MD00573B
Homo sapiens MDA-MB-468 IC50 3870.0 nM 10.1016/j.bmc.2015.11.007
Homo sapiens MDA-MB-468 Inhibition nan % 10.1016/j.ejmech.2019.111954
Homo sapiens MDA-MB-468 LD50 27.0 uM 10.1016/j.bmcl.2019.08.019
Homo sapiens MDA-N GI50 3.069 nM None
Homo sapiens MEG-01 IC50 29.78 nM 10.6019/CHEMBL1201861
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 17133.0 nM None
Homo sapiens Melanocortin receptor 5 Ki 16072.0 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 4466.8 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens MES-SA IC50 0.6 nM 10.1016/s0960-894x(99)00667-8
Homo sapiens MES-SA IC50 2.47 nM 10.1021/acs.jnatprod.1c00100
Homo sapiens MES-SA IC50 5.0 nM 10.1016/j.bmcl.2006.07.020
Homo sapiens MES-SA Log IC50 -8.3 nM 10.1021/jm049405a
Homo sapiens MES-SA Ratio EC50 400.0 None None
Homo sapiens MES-SA Ratio EC50 417.0 None None
Homo sapiens MES-SA RatioGI50 190.0 None 10.1021/jm400575x
Homo sapiens MES-SA RatioGI50 1000.0 None 10.1016/j.ejmech.2016.05.004
Homo sapiens MES-SA Ratio IC50 0.4 None None
Homo sapiens MES-SA Ratio IC50 8.0 None None
Homo sapiens MES-SA Ratio IC50 100.0 None 10.1021/jm200570p
Homo sapiens MES-SA Ratio IC50 333.0 None 10.1016/j.bmcl.2012.10.077
Homo sapiens MES-SA Ratio IC50 338.0 None 10.1016/j.bmcl.2011.01.096
Homo sapiens MES-SA Ratio IC50 338.0 None 10.1016/j.bmcl.2011.01.097
Homo sapiens MES-SA/Dx5 GI50 63.0 nM 10.1021/jm0205200
Homo sapiens MES-SA/Dx5 GI50 1800.0 nM 10.1021/acs.jmedchem.8b00164
Homo sapiens MES-SA/Dx5 GI50 10000.0 nM 10.1021/jm0205200
Homo sapiens MES-SA/Dx5 IC50 0.04 nM 10.1021/jm010974h
Homo sapiens MES-SA/Dx5 IC50 0.3 nM 10.1016/s0960-894x(99)00667-8
Homo sapiens MES-SA/Dx5 IC50 210.0 nM 10.1021/acs.jmedchem.7b01457
Homo sapiens MES-SA/Dx5 IC50 400.0 nM 10.1021/acs.jnatprod.1c00100
Homo sapiens MES-SA/Dx5 IC50 2700.0 nM 10.1016/s0960-894x(99)00667-8
Homo sapiens MES-SA/Dx5 IC50 5000.0 nM 10.1016/j.bmcl.2006.07.020
Homo sapiens MES-SA/Dx5 Ratio IC50 0.001 None None
Homo sapiens MEXF514 IC50 1030.0 nM 10.1016/s0960-894x(02)01002-8
Homo sapiens MFE-280 Activity 22.1 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MFE-280 Activity 34.74 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MFE-280 Activity 39.59 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MFE-296 Activity 19.73 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MFE-296 Activity 26.72 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MFE-296 Activity 51.88 % 10.1016/j.bmcl.2017.07.063
Homo sapiens MFH-ino IC50 2.68 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 9501.27 nM 10.6019/CHEMBL1201861
Homo sapiens MGC-803 Activity nan None 10.1021/acs.jmedchem.2c00549
Homo sapiens MGC-803 IC50 3.8 nM 10.1021/acs.jnatprod.0c00189
Homo sapiens MGC-803 IC50 45.22 nM 10.1016/j.ejmech.2020.112618
Homo sapiens MGC-803 IC50 830.0 nM 10.1016/j.bmcl.2016.07.059
Homo sapiens MGC-803 IC50 850.0 nM 10.1016/j.ejmech.2012.03.024
Homo sapiens MGC-803 IC50 850.0 nM 10.1016/j.ejmech.2012.11.002
Homo sapiens MGC-803 IC50 850.0 nM 10.1016/j.ejmech.2013.04.012
Homo sapiens MGC-803 IC50 3800.0 nM 10.1021/acs.jnatprod.9b01165
Homo sapiens MGC-803 Inhibition 15.0 % 10.1016/j.ejmech.2020.112618
Homo sapiens MGC-803 Inhibition 66.56 % 10.1016/j.ejmech.2012.03.024
Homo sapiens MGC-803 TGI 60.3 % 10.1021/acs.jmedchem.2c00549
Homo sapiens MHH-CALL-2 IC50 35.62 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 304.02 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 21.91 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 IC50 6.0 nM 10.1016/j.bmcl.2018.04.018
Homo sapiens MIA PaCa-2 IC50 7.2 nM 10.1021/jm301058f
Homo sapiens MIA PaCa-2 IC50 2500.0 nM 10.1016/j.ejmech.2017.06.043
Homo sapiens MIA PaCa-2 IC50 2500.0 nM 10.1039/C6MD00256K
Homo sapiens MIA PaCa-2 Imax 87.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens MIA PaCa-2 Inhibition nan % None
Homo sapiens MIA PaCa-2 LC50 2.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens MIA PaCa-2 Log IC50 -8.6 nM 10.1021/jm049405a
Homo sapiens MIA PaCa-2 TGI 62.0 % None
Homo sapiens Microtubule-associated protein tau Potency 22387.2 nM None
Homo sapiens Microtubule-associated protein tau Potency 44668.4 nM None
Homo sapiens MKN-45 Activity 23.0 % 10.1016/j.ejmech.2017.09.016
Homo sapiens MKN-45 IC50 0.5 nM 10.1016/j.bmcl.2006.11.008
Homo sapiens MKN-45 IC50 2.6 nM 10.1021/jm050996u
Homo sapiens MKN-45 IC50 89060.0 nM 10.1021/jm8006257
Homo sapiens MKN-45 IC90 204.0 nM 10.1021/jm050996u
Homo sapiens ML-2 IC50 20.47 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 74.65 nM 10.6019/CHEMBL1201861
Homo sapiens MM96L IC50 10000.0 nM 10.1021/acs.jnatprod.8b00572
Homo sapiens MMAC-SF IC50 45.34 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 2952.45 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 18433.93 nM 10.6019/CHEMBL1201861
Homo sapiens MOLM-13 IC50 3.45 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens MOLT-13 IC50 16.37 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 21.53 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 GI50 2.232 nM 10.1016/j.bmcl.2013.12.083
Homo sapiens MOLT-4 GI50 3.981 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens MOLT-4 GI50 4.426 nM None
Homo sapiens MOLT-4 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens MOLT-4 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens MOLT-4 GI50 32.0 nM 10.1021/jm400479p
Homo sapiens MOLT-4 IC50 1.493 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 IC50 1.6 nM 10.1021/jm00031a022
Homo sapiens MOLT-4 IC50 1.8 nM 10.1021/np300897v
Homo sapiens MOLT-4 IC50 2.2 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens MOLT-4 IC50 2.7 nM 10.1021/jm301581y
Homo sapiens MOLT-4 IC50 2700.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens MOLT-4 Imax 97.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens MOLT-4 LC50 2.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MONO-MAC-6 IC50 30.23 nM 10.6019/CHEMBL1201861
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 22387.2 nM None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens MPP-89 IC50 1941.82 nM 10.6019/CHEMBL1201861
Homo sapiens MRC5 ED50 nan None 10.1016/j.bmcl.2007.02.051
Homo sapiens MRC5 IC50 0.52 nM 10.1021/acs.jnatprod.1c00143
Homo sapiens MRC5 IC50 0.52 nM 10.1021/acs.jnatprod.6b01013
Homo sapiens MRC5 IC50 0.52 nM 10.1021/acs.jnatprod.9b01247
Homo sapiens MRC5 IC50 80.0 nM 10.1021/jm501599u
Homo sapiens MRC5 IC50 523.0 nM 10.1021/acsmedchemlett.1c00711
Homo sapiens MRC5 IC50 25000.0 nM 10.1016/j.ejmech.2020.112670
Homo sapiens MRC5 IC50 200000.0 nM 10.1016/j.ejmech.2019.01.076
Homo sapiens MRC5 LD50 nan None 10.1021/np9805084
Homo sapiens MRK-nu-1 IC50 2.99 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 165.37 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 1439.05 nM 10.6019/CHEMBL1201861
Homo sapiens Multidrug resistance-associated protein 1 Activity 66.0 % 10.1016/s0005-2736(97)00003-5
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Multidrug resistance-associated protein 7 Activity 22.1 % 10.1124/mol.63.2.351
Homo sapiens Multidrug resistance protein 3 Activity nan None 10.1038/nrd3028
Homo sapiens Mu opioid receptor AC50 24309.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens MV4-11 IC50 1.62 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens MV4-11 IC50 4.747 nM 10.6019/CHEMBL1201861
Homo sapiens MV4-11 IC50 17.0 nM 10.1021/acs.jnatprod.8b00197
Homo sapiens MV4-11 Imax 99.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens MV4-11 LC50 10.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens MX1 Activity 33.1 % 10.1016/j.bmcl.2011.09.026
Homo sapiens MX1 Activity 50.0 % 10.1016/j.bmc.2009.02.029
Homo sapiens MX1 IC50 5.59 nM 10.1016/j.bmc.2015.02.057
Homo sapiens MX1 IC50 22.5 nM 10.1021/jm060197r
Homo sapiens MX1 IC50 35.0 nM 10.1016/j.bmc.2008.04.024
Homo sapiens MX1 IC50 35.0 nM 10.1016/j.bmc.2010.01.061
Homo sapiens MX1 IC50 35.0 nM 10.1016/j.bmc.2010.11.030
Homo sapiens MX1 IC50 46.0 nM 10.1016/j.bmc.2008.12.022
Homo sapiens MX1 IC50 46.0 nM 10.1016/j.bmc.2009.06.018
Homo sapiens MZ1-PC IC50 0.7294 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 47.42 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 40.4 nM 10.6019/CHEMBL1201861
Homo sapiens NALM-6 IC50 12.14 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 26.87 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 31508.99 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 4.912 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 7813.9 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 49.79 nM 10.6019/CHEMBL1201861
Homo sapiens NB-4 IC50 30.0 nM 10.1021/np400070x
Homo sapiens NB-4 IC50 30.0 nM 10.1021/np400379u
Homo sapiens NB-4 IC50 30.0 nM 10.1021/np4004068
Homo sapiens NB-4 IC50 100.0 nM 10.1021/np800484j
Homo sapiens NB-4 IC50 100.0 nM 10.1021/np9000366
Homo sapiens NB5 IC50 165.97 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 156.23 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 113.01 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 4403.76 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 17.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI/ADR-RES Activity nan None 10.1016/j.bmc.2019.02.046
Homo sapiens NCI/ADR-RES Activity nan None 10.1021/acs.jmedchem.8b00813
Homo sapiens NCI/ADR-RES Activity nan None 10.1021/acs.jnatprod.7b00967
Homo sapiens NCI/ADR-RES EC50 10000.0 nM 10.1016/j.bmcl.2005.11.094
Homo sapiens NCI/ADR-RES ED50 1.5 uM 10.1016/j.bmcl.2008.09.103
Homo sapiens NCI/ADR-RES ED50 1.53 nM 10.1016/j.bmcl.2005.10.063
Homo sapiens NCI/ADR-RES ED50 2.0 uM 10.1016/j.bmcl.2008.10.010
Homo sapiens NCI/ADR-RES GI50 630.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens NCI/ADR-RES GI50 630.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens NCI/ADR-RES GI50 3111.72 nM None
Homo sapiens NCI/ADR-RES GI50 3162.28 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens NCI/ADR-RES GI50 5943.0 nM 10.1021/acs.jmedchem.8b00164
Homo sapiens NCI/ADR-RES GI50 8000.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens NCI/ADR-RES GI50 15000.0 nM 10.1016/s0960-894x(98)00477-6
Homo sapiens NCI/ADR-RES GI50 50000.0 nM 10.1016/s0960-894x(99)00276-0
Homo sapiens NCI/ADR-RES IC50 181.0 nM 10.1016/j.ejmech.2020.112940
Homo sapiens NCI/ADR-RES IC50 299.0 nM 10.1021/jm025540g
Homo sapiens NCI/ADR-RES IC50 800.0 nM 10.1016/j.bmcl.2021.127923
Homo sapiens NCI/ADR-RES IC50 1300.0 nM 10.1016/j.bmcl.2008.09.109
Homo sapiens NCI/ADR-RES IC50 3100.0 nM 10.1016/j.ejmech.2018.04.042
Homo sapiens NCI/ADR-RES IC50 3300.0 nM 10.1021/jm3013097
Homo sapiens NCI/ADR-RES IC50 3300.0 nM 10.1021/jm500561a
Homo sapiens NCI/ADR-RES IC50 5000.0 nM 10.1021/ml4004793
Homo sapiens NCI/ADR-RES IC50 6263.0 nM 10.1021/jm2003427
Homo sapiens NCI/ADR-RES IC50 9153.0 nM 10.1021/acs.jmedchem.6b00158
Homo sapiens NCI/ADR-RES IC50 9335.0 nM 10.1021/acs.jmedchem.1c02159
Homo sapiens NCI/ADR-RES IC50 10000.0 nM 10.1016/j.bmc.2019.02.046
Homo sapiens NCI/ADR-RES IC50 10000.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens NCI/ADR-RES IC50 17680.0 nM 10.1016/j.ejmech.2019.01.005
Homo sapiens NCI/ADR-RES IC50 58700.0 nM 10.1016/j.ejmech.2021.113336
Homo sapiens NCI/ADR-RES IC50 100000.0 nM 10.1016/j.ejmech.2018.07.029
Homo sapiens NCI/ADR-RES IC50 2500000.0 nM 10.1016/j.bmc.2016.11.026
Homo sapiens NCI/ADR-RES IC50 9000000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens NCI/ADR-RES ID50 10000.0 nM 10.1016/s0960-894x(02)00153-1
Homo sapiens NCI/ADR-RES Ratio ED50 1.0 None 10.1016/j.bmcl.2008.09.103
Homo sapiens NCI/ADR-RES TGI nan None 10.1016/j.bmc.2018.09.025
Homo sapiens NCI-H1092 IC50 1307.19 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 125.58 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 12133.4 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 Activity nan None 10.1021/acs.jnatprod.0c01322
Homo sapiens NCI-H1299 EC50 98.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens NCI-H1299 EC50 163.0 nM 10.1021/jm049640t
Homo sapiens NCI-H1299 IC50 5.0 nM 10.1016/j.bmcl.2020.127557
Homo sapiens NCI-H1299 IC50 9.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens NCI-H1299 IC50 15.0 nM 10.1016/j.bmc.2007.03.041
Homo sapiens NCI-H1299 IC50 15.0 nM 10.1021/jm990355x
Homo sapiens NCI-H1299 IC50 35.0 nM 10.1016/j.bmc.2007.03.041
Homo sapiens NCI-H1299 IC50 35.0 nM 10.1021/jm990355x
Homo sapiens NCI-H1299 IC50 37.7 nM 10.1021/jm040056u
Homo sapiens NCI-H1299 IC50 1500.0 nM 10.1021/acs.jnatprod.6b00924
Homo sapiens NCI-H1299 IC50 7830.0 nM 10.1016/j.ejmech.2017.11.023
Homo sapiens NCI-H1304 IC50 52.08 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 9.138 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 5003.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 192.27 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 12.31 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1437 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens NCI-H1522 IC50 152.66 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 49.53 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 4.687 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 3.17 10'-8mg/ml 10.1016/j.bmcl.2016.02.055
Homo sapiens NCI-H1650 IC50 70.0 nM 10.1016/j.bmcl.2017.06.019
Homo sapiens NCI-H1650 IC50 1000.0 nM 10.1021/acs.jnatprod.6b00887
Homo sapiens NCI-H1650 IC50 1046.51 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1694 IC50 370.0 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 18385.11 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1792 GI 7.0 % None
Homo sapiens NCI-H1792 GI 19.0 % None
Homo sapiens NCI-H1792 GI 66.0 % None
Homo sapiens NCI-H1792 GI 96.0 % None
Homo sapiens NCI-H1792 GI 183.0 % None
Homo sapiens NCI-H1838 IC50 4185.73 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 139.24 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 64.24 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 31.31 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1975 GI50 5.77 nM 10.1021/acs.jmedchem.6b00324
Homo sapiens NCI-H1975 IC50 2.5 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens NCI-H1975 IC50 7.7 nM 10.1016/j.bmcl.2015.03.017
Homo sapiens NCI-H1975 IC50 7.94 nM 10.1021/np500342m
Homo sapiens NCI-H1975 IC50 2800.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens NCI-H1975 IC50 3900.0 nM 10.1016/j.bmc.2018.12.023
Homo sapiens NCI-H2081 IC50 2323.15 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 97.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2107 IC50 150.8 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 27.68 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 2500.0 nM 10.1021/np3003639
Homo sapiens NCI-H2141 IC50 81.0 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2171 IC50 2205.93 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 IC50 222.35 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 Activity nan None 10.1021/acs.jnatprod.0c01322
Homo sapiens NCI-H226 GI50 3.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens NCI-H226 GI50 3.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens NCI-H226 GI50 21.48 nM None
Homo sapiens NCI-H226 GI50 31.62 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens NCI-H226 GI50 20000.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens NCI-H226 IC50 0.003 ug.mL-1 10.1021/jm0009078
Homo sapiens NCI-H226 IC50 6.8 nM 10.1016/j.bmcl.2006.11.008
Homo sapiens NCI-H226 IC50 1714.89 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 Inhibition 71.2 % 10.1021/np040132w
Homo sapiens NCI-H23 GI50 3.963 nM None
Homo sapiens NCI-H23 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens NCI-H23 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens NCI-H23 IC50 1331.9 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H292 IC50 6.0 nM 10.1016/j.bmc.2015.12.016
Homo sapiens NCI-H295R IC50 80.0 nM 10.1021/jm0510676
Homo sapiens NCI-H322M GI50 8.851 nM None
Homo sapiens NCI-H322M GI50 12.5 nM 10.1016/j.bmc.2018.04.010
Homo sapiens NCI-H322M GI50 12.5 nM 10.1016/j.bmc.2020.115887
Homo sapiens NCI-H322M GI50 13.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens NCI-H322M GI50 13.0 nM 10.1021/jm061288r
Homo sapiens NCI-H322M GI50 50.0 nM 10.1021/jm400479p
Homo sapiens NCI-H322M IC50 5186.0 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H322M TGI 6310.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens NCI-H322M TGI 6310.0 nM 10.1021/jm061288r
Homo sapiens NCI-H345 IC50 169.28 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H358 Activity 80.0 % 10.1021/jm800767c
Homo sapiens NCI-H358 IC50 2.0 nM 10.1021/jm500849z
Homo sapiens NCI-H358 IC50 3.8 ug.mL-1 10.1021/jm800767c
Homo sapiens NCI-H358 IC50 7.9 nM 10.1021/jm501599u
Homo sapiens NCI-H358 IC50 10.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens NCI-H441 IC50 150.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens NCI-H446 IC50 21.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 Activity 14.0 % 10.1021/np030266u
Homo sapiens NCI-H460 Activity 15.5 % 10.1021/np030266u
Homo sapiens NCI-H460 Activity 19.7 uM 10.1016/j.ejmech.2022.114832
Homo sapiens NCI-H460 Activity 70.5 % 10.1021/np030266u
Homo sapiens NCI-H460 Activity nan None 10.1016/j.ejmech.2019.111752
Homo sapiens NCI-H460 Activity nan None 10.1021/acs.jnatprod.0c01322
Homo sapiens NCI-H460 ED50 0.015 uM 10.1021/jm010231w
Homo sapiens NCI-H460 FC nan None 10.1021/np200355n
Homo sapiens NCI-H460 GI 87.48 % 10.1016/j.bmc.2013.11.037
Homo sapiens NCI-H460 GI50 1.65 nM 10.1039/C9MD00127A
Homo sapiens NCI-H460 GI50 1.76 nM 10.1021/acs.jmedchem.9b00551
Homo sapiens NCI-H460 GI50 2.958 nM None
Homo sapiens NCI-H460 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens NCI-H460 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens NCI-H460 GI50 7.0 nM 10.1016/j.bmcl.2004.09.069
Homo sapiens NCI-H460 GI50 21.9 nM 10.1021/np50103a016
Homo sapiens NCI-H460 GI50 24.0 nM 10.1021/np200041v
Homo sapiens NCI-H460 GI50 30.0 nM 10.1021/jm300705j
Homo sapiens NCI-H460 GI50 100.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens NCI-H460 IC30 3.6 uM 10.1021/np200241c
Homo sapiens NCI-H460 IC30 440.0 uM 10.1021/np200241c
Homo sapiens NCI-H460 IC50 0.14 nM 10.1021/jm010974h
Homo sapiens NCI-H460 IC50 0.6 nM 10.1021/acsmedchemlett.1c00711
Homo sapiens NCI-H460 IC50 1.0 nM 10.1016/j.bmcl.2020.127557
Homo sapiens NCI-H460 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens NCI-H460 IC50 1.0 nM 10.1021/acs.jnatprod.7b00014
Homo sapiens NCI-H460 IC50 4.0 nM 10.1016/j.bmcl.2017.12.039
Homo sapiens NCI-H460 IC50 4.0 nM 10.1021/jm200436t
Homo sapiens NCI-H460 IC50 4.9 nM 10.1021/np8006556
Homo sapiens NCI-H460 IC50 5.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens NCI-H460 IC50 5.0 nM 10.1016/j.ejmech.2022.114832
Homo sapiens NCI-H460 IC50 6.0 nM 10.1021/acsmedchemlett.7b00189
Homo sapiens NCI-H460 IC50 6.01 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens NCI-H460 IC50 7.0 nM 10.1016/S0960-894X(97)10152-4
Homo sapiens NCI-H460 IC50 7.0 nM 10.1021/acsmedchemlett.7b00189
Homo sapiens NCI-H460 IC50 8.0 nM 10.1016/j.bmcl.2011.12.074
Homo sapiens NCI-H460 IC50 9.5 nM 10.1021/np030266u
Homo sapiens NCI-H460 IC50 9.5 nM 10.1021/np030353m
Homo sapiens NCI-H460 IC50 10.0 nM 10.1016/j.bmc.2011.06.010
Homo sapiens NCI-H460 IC50 10.0 nM 10.1016/j.bmcl.2014.07.035
Homo sapiens NCI-H460 IC50 10.0 nM 10.1016/j.ejmech.2010.04.032
Homo sapiens NCI-H460 IC50 10.0 nM 10.1016/s0960-894x(01)00759-4
Homo sapiens NCI-H460 IC50 10.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens NCI-H460 IC50 10.0 nM 10.1021/jm0307685
Homo sapiens NCI-H460 IC50 10.0 nM 10.1021/jm0605031
Homo sapiens NCI-H460 IC50 10.0 nM 10.1021/jm0708984
Homo sapiens NCI-H460 IC50 10.0 nM 10.1021/jm501599u
Homo sapiens NCI-H460 IC50 12.0 nM 10.1016/j.bmcl.2005.10.022
Homo sapiens NCI-H460 IC50 14.6 nM 10.1021/jm101388d
Homo sapiens NCI-H460 IC50 70.0 nM 10.1021/jm801338r
Homo sapiens NCI-H460 IC50 80.0 nM 10.1016/j.ejmech.2019.01.076
Homo sapiens NCI-H460 IC50 117.0 nM 10.1021/acsmedchemlett.1c00711
Homo sapiens NCI-H460 IC50 8000.0 nM 10.1021/np200355n
Homo sapiens NCI-H460 IC50 9400.0 nM 10.1021/np200241c
Homo sapiens NCI-H460 IC50 2078000.0 nM 10.1021/np200241c
Homo sapiens NCI-H460 LC50 1000.0 nM 10.1021/np50103a016
Homo sapiens NCI-H460 TGI 40.0 % 10.1021/acs.jmedchem.1c00100
Homo sapiens NCI-H460 TGI 56.92 % 10.1016/j.ejmech.2022.114463
Homo sapiens NCI-H460 TGI 60.4 % 10.1021/acs.jmedchem.7b00273
Homo sapiens NCI-H460 TGI 65.21 % 10.1016/j.ejmech.2018.05.003
Homo sapiens NCI-H460 TGI 75.4 % 10.1021/acs.jmedchem.8b00416
Homo sapiens NCI-H460 TGI 80.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens NCI-H460 TGI 85.9 % 10.1021/acs.jmedchem.8b00416
Homo sapiens NCI-H460 TGI 1000.0 nM 10.1021/np50103a016
Homo sapiens NCI-H460 TIME 204.0 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens NCI-H460 TIME 208.8 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens NCI-H460 TIME 237.6 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens NCI-H460 TIME 304.8 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens NCI-H460 TIME 391.2 hr 10.1021/acs.jmedchem.0c01826
Homo sapiens NCI-H510A IC50 6.652 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H520 IC50 8.2 nM 10.1021/acs.jmedchem.7b00958
Homo sapiens NCI-H522 GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens NCI-H522 GI50 4.645 nM None
Homo sapiens NCI-H522 GI50 15.8 nM 10.1016/j.bmc.2018.04.010
Homo sapiens NCI-H522 GI50 15.8 nM 10.1016/j.bmc.2020.115887
Homo sapiens NCI-H522 IC50 nan None 10.1021/np200697j
Homo sapiens NCI-H524 IC50 35.29 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 28.91 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H596 IC50 35.0 nM 10.1016/j.ejmech.2017.03.055
Homo sapiens NCI-H630 IC50 24.0 nM 10.1021/jm050996u
Homo sapiens NCI-H630 IC90 372.0 nM 10.1021/jm050996u
Homo sapiens NCI-H64 IC50 38.57 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 1.9 nM 10.1021/jm061348t
Homo sapiens NCI-H69 IC50 17.78 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 17929.87 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 1736.51 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 2559.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H727 Activity nan None 10.1016/j.bmcl.2018.12.050
Homo sapiens NCI-H727 IC50 10.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens NCI-H727 IC50 nan None 10.1016/j.bmcl.2018.12.050
Homo sapiens NCI-H747 IC50 29.33 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 163.76 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 43.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H838 IC50 26.0 nM 10.1021/jm8006257
Homo sapiens NCI-H889 IC50 55.92 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H929 Imax 82.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens NCI-H929 LC50 3.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens NCI-N87 IC50 5.9 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens NCI-N87 IC50 7.53 nM 10.1021/np500342m
Homo sapiens NCM460 IC50 8.0 nM 10.1021/acs.jnatprod.0c00298
Homo sapiens NCM460 IC50 8.0 nM 10.1021/acs.jnatprod.9b00183
Homo sapiens NCM460 IC50 9.2 nM 10.1016/j.ejmech.2020.113050
Homo sapiens NEC8 IC50 52.86 nM 10.6019/CHEMBL1201861
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 6125.0 nM None
Homo sapiens Neurokinin 2 receptor Ki 2042.0 nM None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide S receptor Potency 12589.3 nM None
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NFF IC50 4.7 nM 10.1016/j.bmcl.2010.07.100
Homo sapiens NH-12 IC50 24165.43 nM 10.6019/CHEMBL1201861
Homo sapiens Niemann-Pick C1 protein Potency 562.3 nM None
Homo sapiens Niemann-Pick C1 protein Potency 3548.1 nM None
Homo sapiens NKM-1 IC50 111.0 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 34.52 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 3.618 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 34.78 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 92.75 nM 10.6019/CHEMBL1201861
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens NOS-1 IC50 6.496 nM 10.6019/CHEMBL1201861
Homo sapiens NSCLC IC50 4.3 nM 10.1016/S0960-894X(97)10152-4
Homo sapiens NTERA-2-cl-D1 IC50 2.088 nM 10.6019/CHEMBL1201861
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 2310.9 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 16360.1 nM None
Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 IC50 7943.28 nM 10.1021/acs.jmedchem.6b01704
Homo sapiens NUGC-3 GI50 20.0 nM 10.1021/jm300705j
Homo sapiens OCI-AML2 IC50 8.521 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 6.617 nM 10.6019/CHEMBL1201861
Homo sapiens OE19 IC50 400.0 nM 10.1021/jm070534b
Homo sapiens OE33 IC50 200.0 nM 10.1021/jm070534b
Homo sapiens OMC-1 IC50 166.88 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 20.36 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 36.73 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 77.48 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 80.0 nM 10.1016/j.bmcl.2010.05.034
Homo sapiens OS-RC-2 IC50 80.0 nM 10.1016/j.ejmech.2010.07.037
Homo sapiens OS-RC-2 IC50 80.0 nM 10.1016/j.ejmech.2011.08.027
Homo sapiens OV-1063 IC50 15.0 nM 10.1021/jm970026+
Homo sapiens OV-90 IC50 5190.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens OVCAR IC50 60.0 nM 10.1007/s00044-011-9824-9
Homo sapiens OVCAR-3 Activity nan None 10.1016/j.bmc.2007.03.041
Homo sapiens OVCAR-3 GI nan None 10.1021/acs.jnatprod.6b00924
Homo sapiens OVCAR-3 GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens OVCAR-3 GI50 3.206 nM None
Homo sapiens OVCAR-3 GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens OVCAR-3 GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens OVCAR-3 GI50 19.7 nM 10.1021/np50103a016
Homo sapiens OVCAR-3 GI50 20.0 nM 10.1021/jm400479p
Homo sapiens OVCAR-3 IC50 0.2 nM 10.1016/j.bmc.2007.03.041
Homo sapiens OVCAR-3 IC50 0.62 nM 10.1021/jm050524f
Homo sapiens OVCAR-3 IC50 1.5 nM 10.1016/j.bmc.2019.115301
Homo sapiens OVCAR-3 IC50 1.8 nM 10.1021/acs.jnatprod.2c01048
Homo sapiens OVCAR-3 IC50 1.8 nM 10.1021/acsmedchemlett.1c00024
Homo sapiens OVCAR-3 IC50 2.0 nM 10.1021/acs.jnatprod.7b00189
Homo sapiens OVCAR-3 IC50 3.3 nM 10.1021/acs.jnatprod.6b00924
Homo sapiens OVCAR-3 IC50 3.3 nM 10.1021/acs.jnatprod.9b01060
Homo sapiens OVCAR-3 IC50 5.0 nM 10.1021/acs.jnatprod.9b00711
Homo sapiens OVCAR-3 IC50 5.1 nM 10.1021/acs.jnatprod.0c00856
Homo sapiens OVCAR-3 IC50 7.5 nM 10.1021/acs.jnatprod.6b01175
Homo sapiens OVCAR-3 IC50 7.5 nM 10.1021/acs.jnatprod.8b00432
Homo sapiens OVCAR-3 IC50 10.0 nM 10.1021/jm0510676
Homo sapiens OVCAR-3 IC50 10.0 nM 10.1021/jm070534b
Homo sapiens OVCAR-3 IC50 11.0 nM 10.1016/j.bmc.2018.03.033
Homo sapiens OVCAR-3 IC50 13.0 nM 10.1016/j.bmc.2018.07.025
Homo sapiens OVCAR-3 IC50 62.01 nM 10.1021/jm050524f
Homo sapiens OVCAR-3 IC50 380.0 nM 10.1016/j.ejmech.2019.06.086
Homo sapiens OVCAR-3 IC50 2700.0 nM 10.1016/j.ejmech.2009.11.001
Homo sapiens OVCAR-3 LC50 608.0 nM 10.1021/np50103a016
Homo sapiens OVCAR-3 TGI 48.7 nM 10.1021/np50103a016
Homo sapiens OVCAR-4 GI50 486.41 nM None
Homo sapiens OVCAR-4 GI50 630.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens OVCAR-4 GI50 630.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens OVCAR-4 IC50 9.041 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 IC50 600000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens OVCAR-4 Inhibition 113.0 % 10.1016/j.ejmech.2019.111965
Homo sapiens OVCAR-5 Activity nan None 10.1021/acsmedchemlett.0c00534
Homo sapiens OVCAR-5 GI 51.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens OVCAR-5 GI 73.0 % 10.1007/s00044-012-0404-4
Homo sapiens OVCAR-5 GI50 7.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens OVCAR-5 GI50 7.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens OVCAR-5 GI50 78.34 nM None
Homo sapiens OVCAR-8 Activity 15.72 % 10.1021/acsmedchemlett.0c00097
Homo sapiens OVCAR-8 Activity 34.28 % 10.1021/acsmedchemlett.0c00097
Homo sapiens OVCAR-8 Activity 49.97 % 10.1021/acsmedchemlett.0c00097
Homo sapiens OVCAR-8 Activity nan None 10.1021/acsmedchemlett.0c00097
Homo sapiens OVCAR-8 GI50 4.539 nM None
Homo sapiens OVCAR-8 GI50 5.012 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens OVCAR-8 GI50 7.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens OVCAR-8 GI50 7.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens OVCAR-8 IC50 2.0 nM 10.1021/jm2012886
Homo sapiens OVCAR-8 IC50 3.7 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens OVCAR-8 IC50 4.0 nM 10.1016/j.ejmech.2018.04.042
Homo sapiens OVCAR-8 IC50 4.7 nM 10.1021/jm2003427
Homo sapiens OVCAR-8 IC50 5.0 nM 10.1021/jm3013097
Homo sapiens OVCAR-8 IC50 5.3 nM 10.1016/j.bmcl.2021.127923
Homo sapiens OVCAR-8 IC50 10.0 nM 10.1016/j.bmcl.2018.02.051
Homo sapiens OVCAR-8 IC50 5000.0 nM 10.1016/j.bmc.2016.11.026
Homo sapiens OVCAR-8 Ratio IC50 1333.0 None 10.1021/jm2003427
Homo sapiens P30-OHK IC50 5350.52 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 29048.91 nM 10.6019/CHEMBL1201861
Homo sapiens PA-1 IC50 0.006 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens PA-1 IC50 3.0 nM 10.1021/acs.jmedchem.7b00958
Homo sapiens PA-1 IC50 8.0 nM 10.1016/j.ejmech.2013.03.029
Homo sapiens PA-1 IC90 0.9 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens PANC-1 Activity 1.6 % 10.1016/j.ejmech.2018.03.078
Homo sapiens PANC-1 CD100 100.0 uM 10.1016/j.bmc.2007.10.004
Homo sapiens PANC-1 CD100 100.0 uM 10.1021/np9002433
Homo sapiens PANC-1 GI50 0.127 ug.mL-1 10.1021/acsmedchemlett.6b00077
Homo sapiens PANC-1 GI50 0.1279 ug.mL-1 10.1016/j.bmcl.2019.03.020
Homo sapiens PANC-1 GI50 0.1279 ug.mL-1 10.1016/j.ejmech.2017.01.009
Homo sapiens PANC-1 GI50 0.1279 ug.mL-1 10.1016/j.ejmech.2017.03.065
Homo sapiens PANC-1 GI90 5.715 ug ml-1 10.1016/j.bmcl.2019.03.020
Homo sapiens PANC-1 GI90 5.715 ug ml-1 10.1016/j.ejmech.2017.03.065
Homo sapiens PANC-1 GI90 5.715 ug ml-1 10.1021/acsmedchemlett.6b00077
Homo sapiens PANC-1 IC50 1.1 nM 10.1021/np200431k
Homo sapiens PANC-1 IC50 5.2 nM 10.1021/jm301058f
Homo sapiens PANC-1 IC50 7.0 nM 10.1021/np070547s
Homo sapiens PANC-1 IC50 8.0 nM 10.1021/np100110u
Homo sapiens PANC-1 IC50 9.9 nM 10.1016/j.bmc.2008.10.084
Homo sapiens PANC-1 IC50 9.9 nM 10.1016/j.bmcl.2008.09.109
Homo sapiens PANC-1 IC50 25.7 nM 10.1021/np8006556
Homo sapiens PANC-1 IC50 40.0 nM 10.1016/j.bmc.2018.10.040
Homo sapiens PANC-1 IC50 60.0 nM 10.1021/acs.jmedchem.8b01445
Homo sapiens PANC-1 IC50 260.0 nM 10.1021/np3003639
Homo sapiens PANC-1 IC50 384.1 nM 10.1016/j.ejmech.2011.01.026
Homo sapiens PANC-1 IC50 1000.0 nM 10.1021/np400235s
Homo sapiens PANC-1 IC50 3500.0 nM 10.1021/acs.jnatprod.8b01006
Homo sapiens PANC-1 Log IC50 -5.0 nM 10.1021/jm049405a
Homo sapiens PANC-1 PC100 256.0 uM 10.1021/np070286m
Homo sapiens PANC-1 PC50 100.0 uM 10.1021/acs.jnatprod.7b00375
Homo sapiens PANC-1 PC50 100.0 uM 10.1021/acs.jnatprod.7b00650
Homo sapiens PANC-1 PC50 100.0 uM 10.1021/np9002433
Homo sapiens Panel (12 tumour cell lines) Activity nan None 10.1021/jm060046o
Homo sapiens Panel (12 tumour cell lines) IC70 0.7 nM 10.1016/j.bmcl.2006.03.029
Homo sapiens Panel NCI-60 (60 carcinoma cell lines) Activity 0.0253 uM 10.1016/j.bmcl.2006.05.048
Homo sapiens Panel NCI-60 (60 carcinoma cell lines) GI50 0.1 nM 10.1021/jm049838d
Homo sapiens PBMC Activity nan None 10.1021/np400017k
Homo sapiens PBMC IC50 5000.0 nM 10.1016/j.bmcl.2013.07.032
Homo sapiens PC-3 Activity 0.6 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 1.9 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 5.8 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 8.25 % 10.1016/j.bmcl.2017.07.063
Homo sapiens PC-3 Activity 13.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 14.0 % 10.1021/jm3013008
Homo sapiens PC-3 Activity 14.7 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 15.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 18.1 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 18.4 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 20.78 % 10.1016/j.bmcl.2017.07.063
Homo sapiens PC-3 Activity 21.1 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 25.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 39.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 41.3 % 10.1016/j.bmcl.2010.02.104
Homo sapiens PC-3 Activity 60.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens PC-3 Activity 62.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 70.82 % 10.1016/j.bmcl.2017.07.063
Homo sapiens PC-3 Activity 79.2 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity 79.3 % 10.1021/acs.jmedchem.9b00706
Homo sapiens PC-3 Activity 80.0 None 10.1016/j.ejmech.2007.04.019
Homo sapiens PC-3 Activity 86.0 % 10.1021/jm3013008
Homo sapiens PC-3 Activity 100.0 % 10.1021/jm3013008
Homo sapiens PC-3 Activity nan None 10.1007/s00044-012-0424-0
Homo sapiens PC-3 Activity nan None 10.1016/j.bmc.2007.02.046
Homo sapiens PC-3 Activity nan None 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Activity nan None 10.1016/j.ejmech.2016.02.015
Homo sapiens PC-3 Activity nan None 10.1021/acs.jmedchem.5b00310
Homo sapiens PC-3 Activity nan None 10.1021/acs.jmedchem.7b01858
Homo sapiens PC-3 Activity nan None 10.1021/jm1000858
Homo sapiens PC-3 CC50 2.7 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens PC-3 EC50 0.0097 ug.mL-1 10.1016/j.bmcl.2008.06.099
Homo sapiens PC-3 EC50 0.0097 ug.mL-1 10.1021/np800622a
Homo sapiens PC-3 ED50 8.87 nM 10.1016/j.bmc.2011.01.001
Homo sapiens PC-3 ED50 55.5 nM 10.1016/j.bmcl.2007.02.051
Homo sapiens PC-3 ED50 nan None 10.1021/np030241v
Homo sapiens PC-3 Effective dose nan None 10.1021/jm020548b
Homo sapiens PC-3 FC 0.281 None 10.1038/nchembio790
Homo sapiens PC-3 GI 71.0 % 10.1007/s00044-012-0404-4
Homo sapiens PC-3 GI 72.0 % 10.1016/j.ejmech.2016.11.037
Homo sapiens PC-3 GI50 0.015 nM 10.1021/jm0204136
Homo sapiens PC-3 GI50 3.981 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens PC-3 GI50 4.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens PC-3 GI50 4.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens PC-3 GI50 4.0 nM 10.1021/jm061288r
Homo sapiens PC-3 GI50 5.8 nM 10.1021/acsmedchemlett.7b00131
Homo sapiens PC-3 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens PC-3 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens PC-3 GI50 7.2 nM 10.1039/C2MD20089A
Homo sapiens PC-3 GI50 13.0 nM 10.1016/j.bmcl.2018.04.006
Homo sapiens PC-3 GI50 18.16 nM None
Homo sapiens PC-3 GI50 30.0 nM 10.1016/j.bmc.2020.115433
Homo sapiens PC-3 GI50 100.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens PC-3 GI50 1460.0 nM 10.1016/j.bmcl.2011.07.049
Homo sapiens PC-3 IC50 0.4 nM 10.1021/jm300564b
Homo sapiens PC-3 IC50 0.43 nM 10.1016/j.bmc.2011.06.084
Homo sapiens PC-3 IC50 0.8 nM 10.1016/j.bmc.2009.07.051
Homo sapiens PC-3 IC50 1.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens PC-3 IC50 1.1 nM 10.1021/acs.jmedchem.8b00827
Homo sapiens PC-3 IC50 1.1 nM 10.1021/acs.jmedchem.9b00706
Homo sapiens PC-3 IC50 1.4 nM 10.1016/j.bmcl.2009.03.063
Homo sapiens PC-3 IC50 1.9 nM 10.1021/acs.jmedchem.9b01815
Homo sapiens PC-3 IC50 2.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens PC-3 IC50 2.5 nM 10.1021/ml200259q
Homo sapiens PC-3 IC50 2.9 ug.mL-1 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 IC50 3.4 nM 10.1021/jm049208b
Homo sapiens PC-3 IC50 3.7 nM 10.1021/acs.jmedchem.7b01858
Homo sapiens PC-3 IC50 4.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens PC-3 IC50 4.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens PC-3 IC50 5.0 nM 10.1021/jm061071x
Homo sapiens PC-3 IC50 7.0 nM 10.1016/j.bmcl.2018.04.018
Homo sapiens PC-3 IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens PC-3 IC50 12.0 nM 10.1039/C4MD00344F
Homo sapiens PC-3 IC50 16.0 nM 10.1021/np0303658
Homo sapiens PC-3 IC50 17.0 nM 10.1021/jm050996u
Homo sapiens PC-3 IC50 20.0 nM 10.1021/np400212d
Homo sapiens PC-3 IC50 21.0 nM 10.1021/acs.jmedchem.6b00071
Homo sapiens PC-3 IC50 25.0 nM 10.1016/j.ejmech.2021.113337
Homo sapiens PC-3 IC50 40.0 nM 10.1021/acs.jnatprod.0c00919
Homo sapiens PC-3 IC50 40.0 nM 10.1021/np500768s
Homo sapiens PC-3 IC50 77.0 nM 10.1016/j.bmc.2007.03.041
Homo sapiens PC-3 IC50 77.0 nM 10.1021/np030296x
Homo sapiens PC-3 IC50 120.0 nM 10.1007/s00044-011-9824-9
Homo sapiens PC-3 IC50 140.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens PC-3 IC50 150.0 nM 10.1021/acs.jnatprod.8b00677
Homo sapiens PC-3 IC50 170.0 nM 10.1021/acs.jnatprod.9b00140
Homo sapiens PC-3 IC50 188.0 nM 10.1016/j.bmc.2011.06.084
Homo sapiens PC-3 IC50 200.0 nM 10.1021/np400070x
Homo sapiens PC-3 IC50 200.0 nM 10.1021/np400379u
Homo sapiens PC-3 IC50 200.0 nM 10.1021/np4004068
Homo sapiens PC-3 IC50 200.0 nM 10.1021/np800484j
Homo sapiens PC-3 IC50 200.0 nM 10.1021/np9000366
Homo sapiens PC-3 IC50 670.0 nM 10.1016/j.ejmech.2019.01.076
Homo sapiens PC-3 IC50 1500.0 nM 10.1016/j.ejmech.2013.08.017
Homo sapiens PC-3 IC50 1900.0 nM 10.1039/C6MD00256K
Homo sapiens PC-3 IC50 2600.0 nM 10.1016/j.bmc.2021.116252
Homo sapiens PC-3 IC50 2730.0 nM 10.1016/j.bmc.2008.07.066
Homo sapiens PC-3 IC50 2850.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens PC-3 IC50 4570.0 nM 10.1016/j.ejmech.2017.11.023
Homo sapiens PC-3 IC50 4900.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens PC-3 IC50 7000.0 nM 10.1039/C7MD00169J
Homo sapiens PC-3 IC50 14500.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens PC-3 IC50 50000.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens PC-3 IC50 57200.0 nM 10.1016/j.bmcl.2012.02.009
Homo sapiens PC-3 IC50 nan None 10.1007/s00044-012-0424-0
Homo sapiens PC-3 IC50 nan None 10.1016/j.bmc.2010.01.061
Homo sapiens PC-3 IC50 nan None 10.1016/j.bmc.2010.11.030
Homo sapiens PC-3 IC50 nan None 10.1021/np500836y
Homo sapiens PC-3 IC90 832.0 nM 10.1021/jm050996u
Homo sapiens PC-3 ID50 4.0 nM 10.1016/s0960-894x(02)00153-1
Homo sapiens PC-3 Inhibition 44.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Inhibition 48.0 % 10.1016/j.bmc.2014.04.025
Homo sapiens PC-3 Inhibition 91.7 % 10.1021/np040132w
Homo sapiens PC-3 LC50 100000.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens PC-3 LCK 0.3 None 10.1073/pnas.0611340104
Homo sapiens PC-3 LCK 1.5 None 10.1073/pnas.0611340104
Homo sapiens PC-3 LCK 3.4 None 10.1073/pnas.0611340104
Homo sapiens PC-3 LCK 3.8 None 10.1073/pnas.0611340104
Homo sapiens PC-3 LD50 0.0027 ug ml-1 10.1021/np9805084
Homo sapiens PC-3 Log IC50 -8.7 nM 10.1021/jm049405a
Homo sapiens PC-3 Ratio IC50 437.0 None 10.1016/j.bmc.2011.06.084
Homo sapiens PC-3 Ratio IC50 437.0 None 10.1021/jm300564b
Homo sapiens PC-3 T/C 0.0 % 10.1073/pnas.0611340104
Homo sapiens PC-3 T/C 0.6 % 10.1073/pnas.0611340104
Homo sapiens PC-3 T/C 6.1 % 10.1073/pnas.0611340104
Homo sapiens PC-3 T/C 49.2 % 10.1073/pnas.0611340104
Homo sapiens PC-3 TGI 30.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens PC-3 TGI 47.8 % 10.1021/acs.jmedchem.1c00966
Homo sapiens PC-3 TGI 79.1 % 10.1021/jm3013008
Homo sapiens PC-3 TGI 101.2 % 10.1021/acs.jmedchem.9b00706
Homo sapiens PC-3 TGI 10000.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens PC-3 TGI 10000.0 nM 10.1021/jm061288r
Homo sapiens PC-3 TGI 12590.0 nM 10.1016/j.ejmech.2010.11.013
Homo sapiens PC-6 GI50 0.00127 ug.mL-1 10.1016/s0960-894x(02)00891-0
Homo sapiens PC-6 GI50 0.00127 ug.mL-1 10.1021/acs.jmedchem.1c00790
Homo sapiens PC-9 IC50 0.056 nM 10.1016/j.bmc.2020.115557
Homo sapiens PC-9 IC50 2.7 nM 10.1021/acs.jnatprod.7b01006
Homo sapiens PC-9 IC50 3700.0 nM 10.1016/j.bmc.2018.12.023
Homo sapiens PEO1 IC50 7000.0 nM None
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 37933.0 nM None
Homo sapiens Peregrin Delta TM -2.68 C 10.6019/CHEMBL5308504
Homo sapiens Peripheral myelin protein 22 Potency 47.8 nM None
Homo sapiens Peroxisome proliferator-activated receptor delta Potency 44668.4 nM None
Homo sapiens Peroxisome proliferator-activated receptor gamma Potency 28183.8 nM None
Homo sapiens PF-382 IC50 23.78 nM 10.6019/CHEMBL1201861
Homo sapiens PG-49 cell line IC50 0.31 nM 10.1016/s0960-894x(02)00694-7
Homo sapiens PG-49 cell line IC50 2.14 nM 10.1016/s0960-894x(02)00694-7
Homo sapiens P-glycoprotein 1 Activity 103.48 % 10.1016/j.ejmech.2020.113107
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bbrc.2004.01.156
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.bmcl.2005.10.063
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/s0196-9781(03)00194-3
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1022242607418
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/a:1025001131513
Homo sapiens P-glycoprotein 1 Activity nan None 10.1023/b:pham.0000026434.82855.69
Homo sapiens P-glycoprotein 1 Activity nan None 10.1038/nrd3028
Homo sapiens P-glycoprotein 1 Activity nan None 10.1158/0008-5472.can-03-3474
Homo sapiens P-glycoprotein 1 Activity nan None 10.1159/000077803
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 FC 22.6 None 10.1016/j.ejmech.2021.113336
Homo sapiens P-glycoprotein 1 IC50 2596.0 nM 10.1016/j.bmc.2012.12.010
Homo sapiens P-glycoprotein 1 IC50 2600.0 nM 10.1021/jm400639z
Homo sapiens P-glycoprotein 1 IC50 53900.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 54000.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 IC50 70200.0 nM 10.1006/bbrc.2001.6000
Homo sapiens P-glycoprotein 1 Inhibition nan % 10.1016/j.bmc.2013.11.037
Homo sapiens P-glycoprotein 1 Km 14.0 nM None
Homo sapiens P-glycoprotein 1 Km 700.0 nM 10.1016/j.bmcl.2005.03.038
Homo sapiens P-glycoprotein 1 Km 16500.0 nM None
Homo sapiens P-glycoprotein 1 % maximum response 0.98 % None
Homo sapiens P-glycoprotein 1 Papp 1.25 nm/s None
Homo sapiens P-glycoprotein 1 Papp 135.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio 50.0 None 10.1016/j.bmcl.2005.03.038
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 2.63 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 108.0 None None
Homo sapiens P-glycoprotein 1 Vmax 35.0 uM 10.1016/j.bmcl.2005.03.038
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens PPC-1 IC50 3.4 nM 10.1021/jm049208b
Homo sapiens Prelamin-A/C Potency 1.8 nM None
Homo sapiens Prelamin-A/C Potency 35.5 nM None
Homo sapiens Prelamin-A/C Potency 63.1 nM None
Homo sapiens Prelamin-A/C Potency 223.9 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Proto-oncogene tyrosine-protein kinase MER IC50 4900.0 nM 10.1016/j.bmc.2016.05.025
Homo sapiens PSN1 IC50 1.301 nM 10.6019/CHEMBL1201861
Homo sapiens PT-45 IC50 5.0 nM 10.1021/jm0510676
Homo sapiens PT-45 IC50 5.0 nM 10.1021/jm070534b
Homo sapiens QIMR-WIL IC50 10.33 nM 10.6019/CHEMBL1201861
Homo sapiens Raji IC50 131.17 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos IC50 3.35 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens Ramos-2G6-4C10 IC50 269.54 nM 10.6019/CHEMBL1201861
Homo sapiens Ras-related protein Rab-9A Potency 89.1 nM None
Homo sapiens RCC10RGB IC50 5062.71 nM 10.6019/CHEMBL1201861
Homo sapiens RCC4 IC50 100.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens RCC4/VHL IC50 60.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens RD Activity nan None 10.1021/acs.jmedchem.5b00310
Homo sapiens RD Activity nan None 10.1021/jm500561a
Homo sapiens RD IC50 10000.0 nM 10.1021/acs.jmedchem.5b00310
Homo sapiens RD IC50 14200.0 nM 10.1021/jm500561a
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 11108.0 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Regulator of G-protein signaling 4 Potency 37685.8 nM None
Homo sapiens REH IC50 2311.65 nM 10.6019/CHEMBL1201861
Homo sapiens Retinoid X receptor alpha Potency 5.0 nM None
Homo sapiens RH-1 IC50 38.19 nM 10.6019/CHEMBL1201861
Homo sapiens RKO IC50 2.977 nM 10.6019/CHEMBL1201861
Homo sapiens RKO IC50 10.0 nM 10.1016/j.ejmech.2010.04.032
Homo sapiens RKO IC50 10.0 nM 10.1021/jm0307685
Homo sapiens RKO IC50 10.0 nM 10.1021/jm0605031
Homo sapiens RKO IC50 10.0 nM 10.1021/jm0708984
Homo sapiens RKO IC50 20.0 nM 10.1021/jm801338r
Homo sapiens RKO IC50 3000.0 nM 10.1016/j.ejmech.2010.04.032
Homo sapiens RKO IC50 3000.0 nM 10.1021/jm0307685
Homo sapiens RKO IC50 3000.0 nM 10.1021/jm0605031
Homo sapiens RKO IC50 3000.0 nM 10.1021/jm0708984
Homo sapiens RKO IC50 10000.0 nM 10.1021/jm801338r
Homo sapiens RL IC50 3.0 nM 10.1021/jm900476c
Homo sapiens RL IC50 27224.17 nM 10.6019/CHEMBL1201861
Homo sapiens RL Imax 83.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens RL LC50 3.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens RL95-2 IC50 0.6681 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-6666 IC50 21.49 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-7951 IC50 13.0 nM 10.1021/acsmedchemlett.0c00131
Homo sapiens RPMI-7951 IC50 nan None 10.1021/acs.jmedchem.1c01202
Homo sapiens RPMI-8226 GI50 2.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens RPMI-8226 GI50 2.0 nM 10.1021/jm061288r
Homo sapiens RPMI-8226 GI50 2.673 nM None
Homo sapiens RPMI-8226 GI50 19.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens RPMI-8226 GI50 19.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens RPMI-8226 IC50 11.02 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 1530.0 nM 10.1016/j.ejmech.2019.06.006
Homo sapiens RPMI-8226 Imax 91.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens RPMI-8226 LC50 3.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens RPMI-8226 TGI 5012.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens RPMI-8226 TGI 5012.0 nM 10.1021/jm061288r
Homo sapiens RPMI 8402 IC50 12.56 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 57.12 nM 10.6019/CHEMBL1201861
Homo sapiens RPTEC IC50 0.9 nM 10.1016/j.bmcl.2006.11.008
Homo sapiens RPTEC Ratio IC50 0.33 None 10.1016/j.bmcl.2006.11.008
Homo sapiens RPTEC Ratio IC50 0.56 None 10.1016/j.bmcl.2006.11.008
Homo sapiens RS4-11 IC50 8.357 nM 10.6019/CHEMBL1201861
Homo sapiens RT-112 IC50 70.0 nM 10.1021/acs.jnatprod.0c00919
Homo sapiens RXF 393 GI50 6.486 nM None
Homo sapiens RXF 393 GI50 7.943 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens RXF 393 GI50 15.8 nM 10.1016/j.bmc.2018.04.010
Homo sapiens RXF 393 GI50 15.8 nM 10.1016/j.bmc.2020.115887
Homo sapiens RXF 393 GI50 50.0 nM 10.1021/jm400479p
Homo sapiens RXF 393 IC50 12.57 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 944 IC50 50.0 nM 10.1016/s0960-894x(02)01002-8
Homo sapiens SAOS-2 Activity 1.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens SAOS-2 Activity 42.0 % 10.1016/j.ejmech.2014.05.084
Homo sapiens SBC-1 IC50 50.42 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 2306.78 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 12.04 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 186.85 nM 10.6019/CHEMBL1201861
Homo sapiens SCLC-21H IC50 58.84 nM 10.6019/CHEMBL1201861
Homo sapiens Serine/threonine-protein kinase Aurora-A Delta TM -0.14 C 10.6019/CHEMBL5308504
Homo sapiens Serine/threonine-protein kinase mTOR Potency 130.9 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Potency 369.0 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 8799.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-126 IC50 61.33 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SF-268 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SF-268 GI50 6.577 nM None
Homo sapiens SF-268 GI50 7.943 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SF-268 GI50 12.0 nM 10.1021/np200041v
Homo sapiens SF-268 IC50 10.0 nM 10.1016/j.bmc.2011.06.010
Homo sapiens SF-268 IC50 10.0 nM 10.1016/j.ejmech.2010.04.032
Homo sapiens SF-268 IC50 10.0 nM 10.1021/jm0307685
Homo sapiens SF-268 IC50 10.0 nM 10.1021/jm0605031
Homo sapiens SF-268 IC50 10.0 nM 10.1021/jm0708984
Homo sapiens SF-268 IC50 11.51 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 IC50 15.3 nM 10.1016/j.bmcl.2008.06.066
Homo sapiens SF-268 IC50 21.7 nM 10.1021/np030266u
Homo sapiens SF-268 IC50 21.7 nM 10.1021/np030353m
Homo sapiens SF-268 IC50 50.0 nM 10.1021/jm801338r
Homo sapiens SF-295 GI 22.0 % 10.1016/j.bmcl.2008.07.095
Homo sapiens SF-295 GI nan None 10.1021/jm201428a
Homo sapiens SF-295 GI50 12.08 nM None
Homo sapiens SF-295 GI50 15.85 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SF-295 GI50 25.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SF-295 GI50 25.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SF-295 IC50 24.55 nM 10.1016/j.bmcl.2011.01.096
Homo sapiens SF-295 IC50 56.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens SF-295 IC50 290.0 nM 10.1016/j.bmcl.2008.06.066
Homo sapiens SF-295 IC50 56000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens SF-539 GI50 3.162 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SF-539 GI50 3.66 nM 10.1021/np50103a016
Homo sapiens SF-539 GI50 3.733 nM None
Homo sapiens SF-539 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SF-539 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SF-539 IC50 24.01 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 LC50 25000.0 nM 10.1021/np50103a016
Homo sapiens SF-539 TGI 89.9 nM 10.1021/np50103a016
Homo sapiens SGC-7901 IC50 3340.0 nM 10.1016/j.ejmech.2009.09.017
Homo sapiens SH-4 IC50 18.95 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 478.55 nM 10.6019/CHEMBL1201861
Homo sapiens SH-SY5Y IC50 4.0 nM 10.1016/j.bmcl.2011.12.074
Homo sapiens SH-SY5Y IC50 200.0 nM 10.1021/np800484j
Homo sapiens SH-SY5Y IC50 200.0 nM 10.1021/np9000366
Homo sapiens SH-SY5Y IC50 8560.0 nM 10.1016/j.ejmech.2011.03.050
Homo sapiens SH-SY5Y Potency 2238.7 nM None
Homo sapiens SIG-M5 IC50 3.272 nM 10.6019/CHEMBL1201861
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SiHa GI 49.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens SiHa GI50 10.0 nM 10.1016/j.ejmech.2020.112044
Homo sapiens SiHa GI50 30.0 nM 10.1016/j.bmcl.2008.11.067
Homo sapiens SiHa GI50 30.0 nM 10.1016/j.bmcl.2010.05.074
Homo sapiens SiHa IC50 1.3 ug.mL-1 10.1016/j.bmcl.2005.12.009
Homo sapiens SiHa IC50 1400.0 nM 10.1021/acs.jnatprod.8b00677
Homo sapiens SiHa IC50 3500.0 nM 10.1016/j.bmcl.2006.06.007
Homo sapiens SIMA IC50 345.81 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 3.2 nM 10.1016/j.bmcl.2008.01.060
Homo sapiens SJSA-1 IC50 17.67 nM 10.6019/CHEMBL1201861
Homo sapiens SK-BR-3 Activity nan None 10.1021/acs.jmedchem.1c00870
Homo sapiens SK-BR-3 GI50 6100.0 nM 10.1016/j.bmc.2007.12.014
Homo sapiens SK-BR-3 IC50 1.9 nM 10.1016/j.bmcl.2012.07.023
Homo sapiens SK-BR-3 IC50 100.0 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens SK-BR-3 IC50 110.0 nM 10.1021/np100110u
Homo sapiens SK-BR-3 IC50 110.0 nM 10.1021/np3002173
Homo sapiens SK-BR-3 IC50 12700.0 nM 10.1016/j.bmc.2016.09.062
Homo sapiens SK-HEP1 GI50 11.0 nM 10.1016/j.bmcl.2018.04.006
Homo sapiens SK-HEP1 IC50 240.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens SK-LMS-1 IC50 4.006 nM 10.6019/CHEMBL1201861
Homo sapiens SKM-1 IC50 9394.59 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens SK-MEL IC50 4100.0 nM 10.1016/j.bmc.2009.10.019
Homo sapiens SK-MEL-1 IC50 6708.96 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 Effective dose nan None 10.1021/jm020548b
Homo sapiens SK-MEL-2 GI50 5.012 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SK-MEL-2 GI50 50.7 nM None
Homo sapiens SK-MEL-2 GI50 400.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SK-MEL-2 GI50 400.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SK-MEL-2 IC50 7.2 nM 10.1021/jm050996u
Homo sapiens SK-MEL-2 IC50 9.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens SK-MEL-2 IC50 70.0 nM 10.1021/np010322w
Homo sapiens SK-MEL-2 IC50 8459.76 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 IC90 37.0 nM 10.1021/jm050996u
Homo sapiens SK-MEL-24 IC50 4730.0 nM 10.1021/acsmedchemlett.0c00131
Homo sapiens SK-MEL-28 GI50 179.89 nM None
Homo sapiens SK-MEL-28 GI50 400.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SK-MEL-28 GI50 400.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SK-MEL-28 IC50 1070.0 nM 10.1021/acsmedchemlett.3c00019
Homo sapiens SK-MEL-28 Inhibition 37.0 % 10.1016/j.bmc.2007.04.017
Homo sapiens SK-MEL-28 Log IC50 -8.4 nM 10.1021/jm049405a
Homo sapiens SK-MEL3 IC50 4730.0 nM 10.1021/acsmedchemlett.3c00019
Homo sapiens SK-MEL-5 GI50 3.882 nM None
Homo sapiens SK-MEL-5 GI50 3.981 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SK-MEL-5 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SK-MEL-5 IC50 150.0 nM 10.1021/np3002173
Homo sapiens SK-MES-1 Ratio 0.026 None 10.1021/np0704046
Homo sapiens SK-MM-2 IC50 3543.85 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 73.07 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 86.41 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 316.92 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-SH GI 20.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens SK-N-SH GI50 2190.0 nM 10.1016/j.bmcl.2011.07.049
Homo sapiens SK-OV-3 Activity -1.0 % 10.1016/j.bmc.2008.05.025
Homo sapiens SK-OV-3 Activity nan None 10.1021/acs.jmedchem.0c01826
Homo sapiens SK-OV-3 Activity nan None 10.1021/acs.jmedchem.0c02144
Homo sapiens SK-OV-3 Activity nan None 10.1021/acsmedchemlett.0c00534
Homo sapiens SK-OV-3 GI50 1.34 nM 10.1021/acs.jmedchem.9b00551
Homo sapiens SK-OV-3 GI50 1.36 nM 10.1039/C9MD00127A
Homo sapiens SK-OV-3 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SK-OV-3 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens SK-OV-3 GI50 8.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens SK-OV-3 GI50 8.0 nM 10.1021/jm061288r
Homo sapiens SK-OV-3 GI50 8.81 nM None
Homo sapiens SK-OV-3 GI50 10.0 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SK-OV-3 GI50 nan None 10.1016/j.bmcl.2009.04.020
Homo sapiens SK-OV-3 IC50 2e-08 nM 10.1016/j.bmcl.2019.03.053
Homo sapiens SK-OV-3 IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Homo sapiens SK-OV-3 IC50 0.1 nM 10.1021/np200920c
Homo sapiens SK-OV-3 IC50 1.34 nM 10.1016/j.ejmech.2008.07.021
Homo sapiens SK-OV-3 IC50 2.0 nM 10.1016/j.ejmech.2017.12.004
Homo sapiens SK-OV-3 IC50 2.0 nM 10.1021/acs.jnatprod.0c00064
Homo sapiens SK-OV-3 IC50 2.39 nM 10.1021/acs.jnatprod.7b01047
Homo sapiens SK-OV-3 IC50 2.6 nM 10.1016/j.ejmech.2011.08.034
Homo sapiens SK-OV-3 IC50 2.6 nM 10.1021/jm200488a
Homo sapiens SK-OV-3 IC50 2.7 nM 10.1021/jm301058f
Homo sapiens SK-OV-3 IC50 2.95 nM 10.1021/jm2007722
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1016/j.bmc.2014.04.049
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1016/j.bmc.2017.04.012
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1021/jm101010n
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1021/jm400639z
Homo sapiens SK-OV-3 IC50 3.0 nM 10.1021/np4005079
Homo sapiens SK-OV-3 IC50 3.99 nM 10.1021/acs.jnatprod.7b01047
Homo sapiens SK-OV-3 IC50 4.0 ug.mL-1 10.1021/jm800767c
Homo sapiens SK-OV-3 IC50 4.4 nM 10.1016/j.bmc.2012.12.010
Homo sapiens SK-OV-3 IC50 5.0 nM 10.1016/j.bmc.2018.09.025
Homo sapiens SK-OV-3 IC50 5.0 nM 10.1016/j.bmc.2021.116061
Homo sapiens SK-OV-3 IC50 5.0 nM 10.1016/j.bmc.2023.117217
Homo sapiens SK-OV-3 IC50 5.0 nM 10.1016/j.bmcl.2018.07.039
Homo sapiens SK-OV-3 IC50 5.0 nM 10.1021/acs.jmedchem.6b00237
Homo sapiens SK-OV-3 IC50 5.0 nM 10.1021/jm050996u
Homo sapiens SK-OV-3 IC50 6.0 nM 10.1021/jm200436t
Homo sapiens SK-OV-3 IC50 8.7 ug.mL-1 10.1016/j.bmcl.2005.12.009
Homo sapiens SK-OV-3 IC50 10.0 nM 10.1016/j.bmc.2011.06.010
Homo sapiens SK-OV-3 IC50 10.0 nM 10.1016/j.ejmech.2010.04.032
Homo sapiens SK-OV-3 IC50 10.0 nM 10.1021/jm0307685
Homo sapiens SK-OV-3 IC50 10.0 nM 10.1021/jm0605031
Homo sapiens SK-OV-3 IC50 10.0 nM 10.1021/jm0708984
Homo sapiens SK-OV-3 IC50 12.0 nM 10.1016/j.ejmech.2013.04.008
Homo sapiens SK-OV-3 IC50 14.5 nM 10.1021/jm101388d
Homo sapiens SK-OV-3 IC50 16.0 nM 10.1016/j.bmc.2008.11.036
Homo sapiens SK-OV-3 IC50 31.3 nM 10.1016/j.bmc.2020.115792
Homo sapiens SK-OV-3 IC50 35.0 nM 10.1016/j.bmcl.2013.10.007
Homo sapiens SK-OV-3 IC50 50.0 nM 10.1021/jm801338r
Homo sapiens SK-OV-3 IC50 65.8 nM 10.1016/j.bmcl.2008.10.077
Homo sapiens SK-OV-3 IC50 100.0 nM 10.1016/j.ejmech.2013.01.007
Homo sapiens SK-OV-3 IC50 400.0 nM 10.1021/np3002173
Homo sapiens SK-OV-3 IC50 430.0 nM 10.1016/j.ejmech.2019.06.086
Homo sapiens SK-OV-3 IC50 530.0 nM 10.1016/j.bmc.2009.10.019
Homo sapiens SK-OV-3 IC50 1000.0 nM 10.1016/j.ejmech.2014.06.010
Homo sapiens SK-OV-3 IC50 1200.0 nM 10.1016/j.bmc.2021.116061
Homo sapiens SK-OV-3 IC50 1200.0 nM 10.1016/j.bmc.2023.117217
Homo sapiens SK-OV-3 IC50 1200.0 nM 10.1021/acs.jmedchem.6b00237
Homo sapiens SK-OV-3 IC50 1350.0 nM 10.1021/np030481a
Homo sapiens SK-OV-3 IC50 2430.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens SK-OV-3 IC50 2600.0 nM 10.1021/jm101010n
Homo sapiens SK-OV-3 IC50 2655.0 nM 10.1016/j.bmc.2014.04.049
Homo sapiens SK-OV-3 IC50 4875.0 nM 10.1021/jm2007722
Homo sapiens SK-OV-3 IC50 4875.0 nM 10.1021/np4005079
Homo sapiens SK-OV-3 IC50 6200.0 nM 10.1021/np500768s
Homo sapiens SK-OV-3 IC50 6290.0 nM 10.1016/j.ejmech.2019.03.031
Homo sapiens SK-OV-3 IC50 1010000.0 nM 10.1021/np500768s
Homo sapiens SK-OV-3 IC90 71.0 nM 10.1021/jm050996u
Homo sapiens SK-OV-3 Inhibition 57.1 % 10.1016/j.ejmech.2019.111965
Homo sapiens SK-OV-3 Inhibition nan % None
Homo sapiens SK-OV-3 Ratio 1.0 None 10.1016/s0960-894x(00)00031-7
Homo sapiens SK-OV-3 Ratio 1.0 None 10.1016/s0960-894x(03)00054-4
Homo sapiens SK-OV-3 Ratio 127.0 None 10.1021/np5002253
Homo sapiens SK-OV-3 Ratio 864.0 None 10.1021/jm101010n
Homo sapiens SK-OV-3 Ratio IC50 162.9 None 10.1021/np500768s
Homo sapiens SK-OV-3 Ratio IC50 188.0 None 10.1016/j.bmc.2015.03.061
Homo sapiens SK-OV-3 Ratio IC50 240.0 None 10.1021/acs.jmedchem.6b00237
Homo sapiens SK-OV-3 Ratio IC50 590.0 None 10.1016/j.bmc.2012.12.010
Homo sapiens SK-OV-3 Ratio IC50 885.0 None 10.1016/j.bmc.2014.04.049
Homo sapiens SK-OV-3 Ratio IC50 1000.0 None 10.1016/j.ejmech.2014.06.010
Homo sapiens SK-OV-3 Ratio IC50 1622.0 None 10.1021/jm2007722
Homo sapiens SK-OV-3 Ratio IC50 1625.0 None 10.1021/np4005079
Homo sapiens SK-OV-3 TGI 22.0 % 10.1016/j.bmc.2008.05.025
Homo sapiens SK-OV-3 TGI 15850.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens SK-OV-3 TGI 15850.0 nM 10.1021/jm061288r
Homo sapiens SK-PN-DW IC50 11.12 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 4.803 nM 10.6019/CHEMBL1201861
Homo sapiens SMMC-7721 Activity 3.4 % 10.1016/j.bmc.2017.12.028
Homo sapiens SMMC-7721 Activity 54.7 % 10.1016/j.bmc.2017.12.028
Homo sapiens SMMC-7721 Activity nan None 10.1016/j.bmc.2017.12.028
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1016/j.bmcl.2018.05.038
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1016/j.ejmech.2019.02.025
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.0c00298
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.5b00057
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.6b00508
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.7b00150
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.7b00163
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.7b00514
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.7b00723
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/acs.jnatprod.7b00909
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np100110u
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np200140j
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np300772e
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np400041y
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np400190n
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np400287r
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np4005823
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np400600c
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np400669t
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np4010135
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np5005196
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np500626x
Homo sapiens SMMC-7721 IC50 8.0 nM 10.1021/np501057f
Homo sapiens SMMC-7721 IC50 70.0 nM 10.1021/acs.jnatprod.1c01194
Homo sapiens SMMC-7721 IC50 97.0 nM 10.1016/j.ejmech.2022.114844
Homo sapiens SMMC-7721 IC50 143.0 nM 10.1016/j.bmc.2021.116495
Homo sapiens SMMC-7721 IC50 150.0 nM 10.1021/np3003639
Homo sapiens SMMC-7721 IC50 880.0 nM 10.1016/j.bmcl.2011.11.016
Homo sapiens SMMC-7721 IC50 1420.0 nM 10.1016/j.ejmech.2010.11.014
Homo sapiens SMMC-7721 IC50 2860.0 nM 10.1016/j.bmcl.2008.07.101
Homo sapiens SMMC-7721 IC50 50000.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens SN12C GI50 4.808 nM None
Homo sapiens SN12C GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SN12C GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens SN12K1 GI50 3.273 nM None
Homo sapiens SNB-19 GI50 10.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SNB-19 GI50 10.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SNB-19 GI50 10.0 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SNB-19 GI50 12.11 nM None
Homo sapiens SNB-19 GI50 40.0 nM 10.1021/jm400479p
Homo sapiens SNB-75 GI nan None 10.1021/jm201428a
Homo sapiens SNB-75 GI50 3.776 nM None
Homo sapiens SNB-75 GI50 4.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens SNB-75 GI50 4.0 nM 10.1021/jm061288r
Homo sapiens SNB-75 GI50 7.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SNB-75 GI50 7.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens SNB-75 GI50 8.08 nM 10.1021/np50103a016
Homo sapiens SNB-75 IC50 15.4 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 LC50 1000.0 nM 10.1021/np50103a016
Homo sapiens SNB-75 TGI 77.3 nM 10.1021/np50103a016
Homo sapiens SNB-75 TGI 126.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens SNB-75 TGI 126.0 nM 10.1021/jm061288r
Homo sapiens SNB-78 GI50 9.817 nM None
Homo sapiens SNU1 IC50 294.22 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 IC50 10.08 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-387 IC50 270.0 nM 10.1021/np300832n
Homo sapiens SNU-398 EC50 9.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens SNU-398 EC50 9.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens SNU-398 EC50 11.0 nM 10.1021/jm7010657
Homo sapiens SNU-398 GI50 10.0 nM 10.1016/j.bmc.2009.02.029
Homo sapiens SNU-398 GI50 61.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens SNU-398 GI50 61.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens SNU-398 IC50 0.6 nM 10.1016/j.bmcl.2018.12.004
Homo sapiens SNU-5 IC50 17.01 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C1 IC50 618.87 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 14.96 nM 10.6019/CHEMBL1201861
Homo sapiens Solute carrier family 22 member 1 Inhibition 7.1 % 10.1021/jm8003152
Homo sapiens Solute carrier organic anion transporter family member 1B1 IC50 280.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 16.4 % 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 16.43 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 71.6 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 87.6 % 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B1 Ki 840.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 IC50 260.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 52.9 % 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 52.9 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 62.1 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 94.4 % 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 1B3 Ki 1800.0 nM 10.1016/j.ejmech.2015.01.011
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 30.8 % 10.1021/jm300212s
Homo sapiens SR GI50 2.512 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens SR GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SR GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens SR GI50 16.67 nM None
Homo sapiens SR IC50 10.26 nM 10.6019/CHEMBL1201861
Homo sapiens ST486 IC50 12.04 nM 10.6019/CHEMBL1201861
Homo sapiens SU-DHL-1 IC50 628.9 nM 10.6019/CHEMBL1201861
Homo sapiens SU-DHL-6 GI50 7.9 nM 10.1016/j.ejmech.2019.03.005
Homo sapiens SUP-T1 IC50 23251.25 nM 10.6019/CHEMBL1201861
Homo sapiens Survival motor neuron protein Potency 10000.0 nM None
Homo sapiens SW1573 GI50 1.5 nM 10.1016/j.ejmech.2019.06.073
Homo sapiens SW1573 GI50 1.6 nM 10.1016/j.ejmech.2019.06.073
Homo sapiens SW1573 GI50 4.2 nM 10.1016/j.ejmech.2019.06.073
Homo sapiens SW1573 GI50 5.0 nM 10.1016/j.bmcl.2011.09.069
Homo sapiens SW1573 GI50 196.0 nM 10.1016/j.ejmech.2019.06.073
Homo sapiens SW1573 GI50 1500.0 nM 10.1021/acs.jnatprod.9b00117
Homo sapiens SW1573 GI50 1600.0 nM 10.1021/acs.jnatprod.9b00117
Homo sapiens SW1573 GI50 4200.0 nM 10.1021/acs.jnatprod.9b00117
Homo sapiens SW1573 GI50 196000.0 nM 10.1021/acs.jnatprod.9b00117
Homo sapiens SW1573 RatioGI50 2.6 None 10.1021/acs.jnatprod.9b00117
Homo sapiens SW1573 RatioGI50 3.0 None 10.1016/j.ejmech.2019.06.073
Homo sapiens SW1573 RatioGI50 128.0 None 10.1016/j.ejmech.2019.06.073
Homo sapiens SW1573 RatioGI50 128.0 None 10.1021/acs.jnatprod.9b00117
Homo sapiens SW1990 IC50 10.0 nM 10.1021/acs.jmedchem.2c01208
Homo sapiens SW1990 IC50 180.0 nM 10.1016/j.bmcl.2020.127739
Homo sapiens SW48 IC50 1.0 nM 10.1021/jm900476c
Homo sapiens SW480 Activity 1.13 % 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 Activity 14.7 % 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 Activity 33.6 % 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 Activity 45.6 % 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 FC 0.2 None 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 FC 1.1 None 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 FC 2.0 None 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 IC50 2.0 nM 10.1021/jm900476c
Homo sapiens SW480 IC50 7.0 nM 10.1021/jm500024v
Homo sapiens SW480 IC50 8.0 nM 10.1016/j.bmcl.2018.05.038
Homo sapiens SW480 IC50 8.0 nM 10.1016/j.ejmech.2019.02.025
Homo sapiens SW480 IC50 8.0 nM 10.1016/j.ejmech.2022.114844
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.0c00298
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.1c00342
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.5b00057
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.6b00508
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.7b00150
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.7b00163
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.7b00514
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.7b00723
Homo sapiens SW480 IC50 8.0 nM 10.1021/acs.jnatprod.7b00909
Homo sapiens SW480 IC50 8.0 nM 10.1021/np200140j
Homo sapiens SW480 IC50 8.0 nM 10.1021/np400041y
Homo sapiens SW480 IC50 8.0 nM 10.1021/np4005823
Homo sapiens SW480 IC50 8.0 nM 10.1021/np400600c
Homo sapiens SW480 IC50 8.0 nM 10.1021/np400669t
Homo sapiens SW480 IC50 8.0 nM 10.1021/np4010135
Homo sapiens SW480 IC50 8.0 nM 10.1021/np500626x
Homo sapiens SW480 IC50 8.0 nM 10.1021/np501057f
Homo sapiens SW480 IC50 11.0 nM 10.1021/jm200436t
Homo sapiens SW480 IC50 12.1 nM 10.1021/jm301864s
Homo sapiens SW480 IC50 21.0 nM 10.1016/j.bmcl.2015.01.056
Homo sapiens SW480 IC50 40.0 nM 10.1021/np400190n
Homo sapiens SW480 IC50 40.0 nM 10.1021/np400287r
Homo sapiens SW480 IC50 150.0 nM 10.1021/np300772e
Homo sapiens SW480 IC50 150.0 nM 10.1021/np5005196
Homo sapiens SW480 IC50 190.0 nM 10.1016/j.bmcl.2018.01.036
Homo sapiens SW480 IC50 312.0 nM 10.1016/s0960-894x(03)00543-2
Homo sapiens SW480 IC50 nan None 10.1016/j.bmcl.2021.128066
Homo sapiens SW-620 Activity 32.0 % 10.1021/acs.jmedchem.1c01498
Homo sapiens SW-620 GI 36.0 % 10.1007/s00044-012-0106-y
Homo sapiens SW-620 GI 73.0 % 10.1016/j.bmc.2011.09.060
Homo sapiens SW-620 GI50 3.258 nM None
Homo sapiens SW-620 GI50 4.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens SW-620 GI50 4.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens SW-620 GI50 5.0 nM None
Homo sapiens SW-620 IC50 30.0 nM 10.1016/j.ejmech.2018.02.045
Homo sapiens SW-620 IC50 30.0 nM 10.1021/jm100659v
Homo sapiens SW-620 Imax 96.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens SW-620 Inhibition 41.0 % 10.1016/j.bmcl.2007.10.011
Homo sapiens SW-620 LC50 20.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens SW620/AD300 Activity nan None 10.1021/acs.jmedchem.8b00335
Homo sapiens SW620/AD300 IC50 1970.0 nM 10.1016/j.ejmech.2018.02.045
Homo sapiens SW626 ED50 12.0 pM 10.1021/np800767a
Homo sapiens SW626 GI 0.0 % 10.1021/np800767a
Homo sapiens SW626 GI 98.0 % 10.1021/np800767a
Homo sapiens SW626 IC50 0.01 nM 10.1021/np010322w
Homo sapiens SW626 Inhibition 0.0 % 10.1021/np010322w
Homo sapiens SW626 Inhibition 98.7 % 10.1021/np010322w
Homo sapiens SW684 IC50 5232.88 nM 10.6019/CHEMBL1201861
Homo sapiens SW780 IC50 1.1 nM 10.1021/jm301151t
Homo sapiens SW780 Ratio IC50 900.0 None 10.1021/jm301151t
Homo sapiens SW872 IC50 42.1 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 1.187 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 6.623 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 7.66 nM 10.6019/CHEMBL1201861
Homo sapiens T-24 Log IC50 -8.5 nM 10.1021/jm049405a
Homo sapiens T47D Activity 27.89 % 10.1016/j.bmcl.2017.07.063
Homo sapiens T47D Activity 30.62 % 10.1016/j.bmcl.2017.07.063
Homo sapiens T47D Activity 33.0 % 10.1016/j.bmcl.2007.05.098
Homo sapiens T47D Activity 41.49 % 10.1016/j.bmcl.2017.07.063
Homo sapiens T47D Activity 70.0 % 10.1016/j.bmcl.2007.05.098
Homo sapiens T47D Activity nan None 10.1016/j.ejmech.2019.111990
Homo sapiens T47D EC50 30.0 nM 10.1021/jm049640t
Homo sapiens T47D EC50 35.0 nM 10.1016/j.bmc.2009.02.029
Homo sapiens T47D EC50 36.0 nM 10.1021/jm7010657
Homo sapiens T47D EC50 37.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens T47D EC50 37.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens T47D EC50 37.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens T47D GI50 0.15 nM 10.1016/j.bmcl.2011.09.069
Homo sapiens T47D GI50 10.0 nM 10.1021/jm400479p
Homo sapiens T47D GI50 12.5 nM 10.1016/j.bmc.2020.115887
Homo sapiens T47D GI50 26.0 nM 10.1016/j.bmcl.2009.05.012
Homo sapiens T47D GI50 26.0 nM 10.1016/j.bmcl.2009.05.052
Homo sapiens T47D GI50 26.0 nM 10.1016/j.bmcl.2009.11.025
Homo sapiens T47D GI50 53.95 nM None
Homo sapiens T47D IC50 4.0 nM 10.1021/jm900476c
Homo sapiens T47D IC50 200.0 nM 10.1016/j.bmcl.2016.07.025
Homo sapiens T47D Log IC50 -7.3 nM 10.1021/jm049405a
Homo sapiens T98G Activity 3.23 % 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G Activity 15.0 % 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G Activity 25.6 % 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G Activity 56.2 % 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G Activity nan None 10.1016/j.ejmech.2020.113068
Homo sapiens T98G FC 0.3 None 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G FC 1.1 None 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G FC 5.0 None 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G IC50 12.0 nM 10.1016/j.ejmech.2020.113068
Homo sapiens T98G IC50 740.0 nM 10.1016/j.bmcl.2018.01.036
Homo sapiens T98G IC50 8700.0 nM 10.1021/acs.jnatprod.1c00677
Homo sapiens T98G Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens TALL-1 IC50 50.45 nM 10.6019/CHEMBL1201861
Homo sapiens T-cell line Activity 16.9 % 10.1021/acs.jnatprod.6b00697
Homo sapiens T-cell line Activity 40.8 % 10.1021/acs.jnatprod.6b00697
Homo sapiens T-cell line Activity 42.3 % 10.1021/acs.jnatprod.6b00697
Homo sapiens TE-1 IC50 6.059 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 1.543 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 1.231 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 33.09 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 0.2869 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 524.79 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 14.96 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 5.703 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 1.174 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 3.255 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC1TKB IC50 17.52 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 7.523 nM 10.6019/CHEMBL1201861
Homo sapiens TGW IC50 86.07 nM 10.6019/CHEMBL1201861
Homo sapiens Thiosulfate sulfurtransferase IC50 100000.0 nM 10.1016/j.bmcl.2019.02.028
Homo sapiens THP-1 Activity 71.0 % 10.1021/np3006666
Homo sapiens THP-1 Activity nan None 10.1007/s00044-012-0424-0
Homo sapiens THP-1 GI 62.0 % 10.1007/s00044-012-0312-7
Homo sapiens THP-1 GI 82.54 % 10.1021/np400002p
Homo sapiens THP-1 GI50 0.133 ug.mL-1 10.1021/acsmedchemlett.6b00077
Homo sapiens THP-1 GI50 0.1374 ug.mL-1 10.1016/j.bmcl.2015.08.006
Homo sapiens THP-1 GI90 5.81 ug ml-1 10.1021/acsmedchemlett.6b00077
Homo sapiens THP-1 GI90 5.814 ug ml-1 10.1016/j.bmcl.2015.08.006
Homo sapiens THP-1 IC50 3.01 nM 10.1021/acs.jmedchem.1c01451
Homo sapiens THP-1 IC50 6725.83 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 IC50 nan None 10.1007/s00044-012-0424-0
Homo sapiens THP-1 IC90 98.61 ug.mL-1 10.1021/np400002p
Homo sapiens THP-1 Imax 72.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens THP-1 LC50 30.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thrombopoietin Potency 12589.3 nM None
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thymidine kinase, cytosolic Activity nan None 10.1016/j.bmcl.2006.07.003
Homo sapiens Thyroid hormone receptor beta-1 Potency 707.9 nM None
Homo sapiens TK-10 GI50 19.9 nM 10.1016/j.bmc.2018.04.010
Homo sapiens TK-10 GI50 19.9 nM 10.1016/j.bmc.2020.115887
Homo sapiens TK-10 GI50 113.24 nM None
Homo sapiens TK-10 IC50 33.56 nM 10.6019/CHEMBL1201861
Homo sapiens TOV21G IC50 264.0 nM 10.1016/j.ejmech.2020.112940
Homo sapiens Transcription intermediary factor 1-alpha Delta TM -0.24 C 10.6019/CHEMBL5308504
Homo sapiens TSU IC50 2.1 nM 10.1021/jm049208b
Homo sapiens TSU Inhibition 90.0 % 10.1016/j.bmc.2007.04.029
Homo sapiens Tubulin Activity 41.1 % 10.1016/j.ejmech.2020.112158
Homo sapiens Tubulin Activity 45.9 % 10.1016/j.ejmech.2020.112158
Homo sapiens Tubulin Activity 46.1 % 10.1016/j.ejmech.2020.112158
Homo sapiens Tubulin Activity 59.7 % 10.1016/j.ejmech.2020.112158
Homo sapiens Tubulin Activity 61.5 % 10.1016/j.ejmech.2020.112158
Homo sapiens Tubulin Activity 99.2 % 10.1021/jm501180v
Homo sapiens Tubulin Activity 245.3 % 10.1021/jm301864s
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2007.08.020
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2009.08.046
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2012.04.039
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2013.12.067
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2014.08.008
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2021.116252
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2022.116874
Homo sapiens Tubulin Activity nan None 10.1016/j.bmc.2023.117300
Homo sapiens Tubulin Activity nan None 10.1016/j.bmcl.2007.04.058
Homo sapiens Tubulin Activity nan None 10.1016/j.bmcl.2014.05.096
Homo sapiens Tubulin Activity nan None 10.1016/j.bmcl.2020.127354
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2015.03.005
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2017.07.076
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2018.12.030
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2019.02.003
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2020.112050
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2020.112158
Homo sapiens Tubulin Activity nan None 10.1016/j.ejmech.2022.114372
Homo sapiens Tubulin Activity nan None 10.1021/acs.jmedchem.1c01099
Homo sapiens Tubulin Activity nan None 10.1021/acs.jmedchem.5b01426
Homo sapiens Tubulin Activity nan None 10.1021/acs.jmedchem.6b00158
Homo sapiens Tubulin Activity nan None 10.1021/acs.jmedchem.6b00777
Homo sapiens Tubulin Activity nan None 10.1021/acsmedchemlett.0c00534
Homo sapiens Tubulin Activity nan None 10.1021/jm0704189
Homo sapiens Tubulin Activity nan None 10.1021/jm400479p
Homo sapiens Tubulin Activity nan None 10.1021/jm500670d
Homo sapiens Tubulin Activity nan None 10.1021/np3006666
Homo sapiens Tubulin Activity nan None 10.1039/C3MD00077J
Homo sapiens Tubulin EC50 31.0 nM 10.1016/j.bmcl.2005.10.022
Homo sapiens Tubulin EC50 1230.0 nM 10.1021/jm301864s
Homo sapiens Tubulin ED50 0.5 uM 10.1021/jm061071x
Homo sapiens Tubulin ED90 0.5 uM 10.1039/C1MD00155H
Homo sapiens Tubulin FC 0.82 None 10.1016/j.bmc.2019.115153
Homo sapiens Tubulin GI50 4.6 nM 10.1039/C9MD00164F
Homo sapiens Tubulin GI50 5.2 nM 10.1039/C9MD00164F
Homo sapiens Tubulin GI50 6.0 nM 10.1039/C9MD00164F
Homo sapiens Tubulin IC50 nan None 10.1016/j.bmcl.2005.11.094
Homo sapiens Tubulin IC50 nan None 10.1021/jm061142s
Homo sapiens Tubulin ID50 ratio 0.8 None 10.1016/S0960-894X(00)80073-6
Homo sapiens Tubulin ID50 ratio 1.0 None 10.1016/S0960-894X(00)80073-6
Homo sapiens Tubulin Inhibition 49.55 % 10.1039/d2md00400c
Homo sapiens Tubulin Inhibition 60.0 % 10.1039/d2md00442a
Homo sapiens Tubulin Inhibition 157.12 % 10.1007/s00044-012-0428-9
Homo sapiens Tubulin Inhibition nan % 10.1016/j.bmc.2011.05.031
Homo sapiens Tubulin Inhibition nan % 10.1016/j.bmcl.2016.05.063
Homo sapiens Tubulin Inhibition nan % 10.1016/j.bmcl.2020.127453
Homo sapiens Tubulin Inhibition nan % 10.1016/j.ejmech.2012.12.008
Homo sapiens Tubulin Inhibition nan % 10.1016/j.ejmech.2018.07.044
Homo sapiens Tubulin Inhibition nan % 10.1016/j.ejmech.2020.113117
Homo sapiens Tubulin Inhibition nan % 10.1016/j.ejmech.2021.113897
Homo sapiens Tubulin Inhibition nan % 10.1021/acs.jmedchem.1c01936
Homo sapiens Tubulin Inhibition nan % 10.1021/acs.jmedchem.5b00035
Homo sapiens Tubulin Inhibition nan % 10.1021/acs.jmedchem.5b01086
Homo sapiens Tubulin Inhibition nan % 10.1021/acs.jmedchem.9b00551
Homo sapiens Tubulin Inhibition nan % 10.1021/jm400139w
Homo sapiens Tubulin Inhibition nan % 10.1021/jm4016526
Homo sapiens Tubulin Inhibition nan % 10.1039/C5MD00155B
Homo sapiens Tubulin Inhibition nan % 10.1039/C6MD00562D
Homo sapiens Tubulin Log 1/ratio 0.0 None 10.1016/S0960-894X(00)80073-6
Homo sapiens Tubulin Log 1/ratio 0.0969 None 10.1016/S0960-894X(00)80073-6
Homo sapiens Tubulin Ratio ED50 1.0 None 10.1016/j.bmcl.2005.10.063
Homo sapiens Tubulin alpha Activity nan None 10.1016/j.ejmech.2019.111584
Homo sapiens Tubulin beta-1 chain ED50 ratio 1.0 None 10.1021/jm960505t
Homo sapiens Tubulin beta-3 chain IC50 7.7 nM 10.1016/j.bmc.2020.115887
Homo sapiens Tubulin beta-3 chain IC50 7.7 nM 10.1021/jm400639z
Homo sapiens Tubulin beta-3 chain IC50 9.2 nM 10.1016/j.bmc.2012.12.010
Homo sapiens TUR IC50 26653.3 nM 10.6019/CHEMBL1201861
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase ABL Delta TM 0.38 C 10.6019/CHEMBL5308504
Homo sapiens Tyrosine-protein kinase ABL IC50 10000.0 nM 10.1021/jm500034j
Homo sapiens Tyrosine-protein kinase FYN IC50 23906.0 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosine-protein kinase SRC IC50 10000.0 nM 10.1021/jm500034j
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 2.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 3.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 7.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 9.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 18.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 51.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 58.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 35481.3 nM None
Homo sapiens U-251 Activity nan None 10.1021/acs.jmedchem.5b00686
Homo sapiens U-251 GI50 3.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens U-251 GI50 3.837 nM None
Homo sapiens U-251 GI50 3.981 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens U-251 GI50 6.3 nM 10.1016/j.bmc.2018.04.010
Homo sapiens U-251 GI50 6.3 nM 10.1016/j.bmc.2020.115887
Homo sapiens U-251 IC50 23.0 nM 10.1021/jm500849z
Homo sapiens U-251 IC50 30.0 nM 10.1016/j.bmc.2010.10.019
Homo sapiens U-251 IC50 128.0 nM 10.1016/j.ejmech.2014.06.002
Homo sapiens U-251 IC50 nan None 10.1016/j.bmcl.2011.01.096
Homo sapiens U-251 IC50 nan None 10.1016/j.bmcl.2021.128066
Homo sapiens U-251 TGI 100.0 nM 10.1016/j.ejmech.2014.03.086
Homo sapiens U-266 IC50 398.46 nM 10.6019/CHEMBL1201861
Homo sapiens U2OS Activity nan None 10.1016/j.bmc.2011.01.039
Homo sapiens U2OS Activity nan None 10.1016/j.ejmech.2015.03.005
Homo sapiens U2OS Growth Rate -0.45 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.43 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.32 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.26 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.23 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.21 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.18 None 10.6019/CHEMBL5303304
Homo sapiens U2OS Growth Rate -0.07 None 10.6019/CHEMBL5303304
Homo sapiens U2OS IC50 3.4 nM 10.1021/jm301058f
Homo sapiens U2OS IC50 24.0 nM 10.1021/np700717s
Homo sapiens U2OS IC50 30.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens U373 MG IC50 nan None 10.1016/j.bmcl.2005.12.009
Homo sapiens U373 MG Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens U-698-M IC50 1225.57 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG Activity nan None 10.1016/j.ejmech.2020.113068
Homo sapiens U-87 MG IC50 0.38 nM 10.1016/j.bmc.2020.115557
Homo sapiens U-87 MG IC50 3.2 ug.mL-1 10.1016/j.bmcl.2005.12.009
Homo sapiens U-87 MG IC50 8.0 nM 10.1016/j.ejmech.2020.113068
Homo sapiens U-87 MG IC50 10.0 nM 10.1016/j.ejmech.2021.113754
Homo sapiens U-87 MG IC50 80.0 nM 10.1016/j.bmcl.2006.06.007
Homo sapiens U-87 MG IC50 4186.73 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 4670.0 nM 10.1016/j.bmcl.2018.01.036
Homo sapiens U-87 MG Log IC50 -7.8 nM 10.1021/jm049405a
Homo sapiens U-937 Activity nan None 10.1016/j.bmcl.2013.07.032
Homo sapiens U-937 GI50 2.12 nM 10.1021/acs.jmedchem.6b00324
Homo sapiens U-937 IC50 1.0 nM 10.1021/jm00031a022
Homo sapiens U-937 IC50 1.7 nM 10.1021/acs.jnatprod.6b00810
Homo sapiens U-937 IC50 1.9 nM 10.1021/np300897v
Homo sapiens U-937 IC50 2.3 nM 10.1021/jm301581y
Homo sapiens U-937 IC50 3.37 nM 10.1016/j.bmcl.2012.06.102
Homo sapiens U-937 IC50 2100.0 nM 10.1016/j.bmcl.2015.08.034
Homo sapiens U-937/GTB IC50 5.9 nM 10.1016/j.bmc.2007.03.086
Homo sapiens U-937/GTB IC50 5.9 nM 10.1021/np050424c
Homo sapiens UACC-257 GI50 21.23 nM None
Homo sapiens UACC-257 GI50 40.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens UACC-257 GI50 40.0 nM 10.1021/jm061288r
Homo sapiens UACC-257 IC50 48.49 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 TGI 25120.0 nM 10.1016/j.bmc.2011.06.050
Homo sapiens UACC-257 TGI 25120.0 nM 10.1021/jm061288r
Homo sapiens UACC-62 GI50 3.981 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens UACC-62 GI50 4.188 nM None
Homo sapiens UACC-62 GI50 5.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens UACC-62 GI50 5.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens UACC-62 IC50 6.0 nM 10.1021/acs.jnatprod.6b00893
Homo sapiens UACC-812 IC50 700.0 nM 10.1021/jm900476c
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 39810.7 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 44668.4 nM None
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Potency 3981.1 nM None
Homo sapiens UMSCC1 Activity 29.0 % None
Homo sapiens UMSCC1 Activity 58.0 % None
Homo sapiens UMSCC1 Activity 66.0 % None
Homo sapiens UMSCC1 Activity nan None None
Homo sapiens UMSCC1 FC 2.7 None None
Homo sapiens UMSCC1 FC 3.4 None None
Homo sapiens UMSCC1 FC 5.6 None None
Homo sapiens UMSCC1 FC 13.9 None None
Homo sapiens UMSCC1 GI 8.8 % None
Homo sapiens UMSCC1 GI 13.5 % None
Homo sapiens UMSCC1 GI 13.6 % None
Homo sapiens UMSCC1 GI 14.1 % None
Homo sapiens UMSCC1 GI 14.2 % None
Homo sapiens UMSCC1 GI 19.3 % None
Homo sapiens UMSCC1 GI 25.0 % None
Homo sapiens UMSCC1 GI 30.6 % None
Homo sapiens UMSCC1 GI 33.0 % None
Homo sapiens UMSCC1 GI 34.4 % None
Homo sapiens UMSCC1 GI 36.3 % None
Homo sapiens UMSCC1 GI 48.0 % None
Homo sapiens UMSCC1 GI 51.0 % None
Homo sapiens UMSCC1 GI 52.6 % None
Homo sapiens UMSCC1 GI 58.0 % None
Homo sapiens UMSCC1 GI 63.0 % None
Homo sapiens UMSCC1 GI 68.4 % None
Homo sapiens UMSCC1 GI 69.0 % None
Homo sapiens UMSCC1 GI 70.0 % None
Homo sapiens UMSCC1 GI 78.4 % None
Homo sapiens UMSCC1 GI nan None None
Homo sapiens UMSCC1 Inhibition 16.0 % None
Homo sapiens UMSCC1 Inhibition 24.0 % None
Homo sapiens UMSCC1 Inhibition 33.0 % None
Homo sapiens UMSCC1 mortality 8.0 % None
Homo sapiens UMSCC1 mortality 75.0 % None
Homo sapiens UMSCC1 TIME 96.0 hr None
Homo sapiens UMSCC1 TIME 288.0 hr None
Homo sapiens UMSCC1 TIME 408.0 hr None
Homo sapiens UO-31 GI50 125.0 nM 10.1016/j.bmc.2018.04.010
Homo sapiens UO-31 GI50 125.0 nM 10.1016/j.bmc.2020.115887
Homo sapiens UO-31 GI50 1000.0 nM 10.1016/s0960-894x(98)00226-1
Homo sapiens UO-31 GI50 1093.96 nM None
Homo sapiens UO-31 IC50 240000.0 nM 10.1021/acs.jmedchem.7b01644
Homo sapiens VA-ES-BJ IC50 2.996 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vitamin D receptor Potency 17.8 nM None
Homo sapiens WI-38 IC50 0.02 ug.mL-1 10.1021/np0604533
Homo sapiens WI-38 IC50 0.05 ug.mL-1 10.1021/np070089n
Homo sapiens WI-38 IC50 40.0 nM 10.1021/np068015j
Homo sapiens WI-38 IC50 50.0 nM 10.1021/np400212d
Homo sapiens WI-38 IC50 10000.0 nM 10.1021/acs.jmedchem.2c00608
Homo sapiens WI-38 LD50 35.0 uM 10.1016/j.bmcl.2019.08.019
Homo sapiens WI-38 VA13 CC50 20.0 nM 10.1016/j.bmcl.2019.06.035
Homo sapiens WI-38 VA13 IC50 0.0043 ug.mL-1 10.1016/j.bmcl.2006.09.068
Homo sapiens WI-38 VA13 IC50 0.01 ug.mL-1 10.1021/np0604533
Homo sapiens WI-38 VA13 IC50 0.01 ug.mL-1 10.1021/np070089n
Homo sapiens WI-38 VA13 IC50 4.3 nM 10.1021/np050417o
Homo sapiens WI-38 VA13 IC50 5.0 nM 10.1016/j.bmcl.2007.04.030
Homo sapiens WI-38 VA13 IC50 5.0 nM 10.1021/np040072u
Homo sapiens WI-38 VA13 IC50 5.0 nM 10.1021/np0680073
Homo sapiens WI-38 VA13 IC50 5.0 nM 10.1021/np068015j
Homo sapiens WI-38 VA13 IC50 5.9 nM 10.1021/np0600447
Homo sapiens WI-38 VA13 IC50 5000.0 nM 10.1021/np068066g
Homo sapiens WiDr GI50 0.22 nM 10.1016/j.bmcl.2011.09.069
Homo sapiens WiDr IC50 0.003 ug.mL-1 10.1016/j.bmc.2007.03.041
Homo sapiens WiDr IC50 0.003 ug.mL-1 10.1021/jm0009078
Homo sapiens WiDr Log IC50 -9.0 nM 10.1021/jm049405a
Homo sapiens WiDr Ratio 1.0 None 10.1016/s0960-894x(00)00031-7
Homo sapiens WM 266-4 IC50 0.32 nM 10.1016/j.ejmech.2019.111665
Homo sapiens WRL68 IC50 0.0035 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens WRL68 IC50 0.004 ug.mL-1 10.1016/j.ejmech.2014.10.013
Homo sapiens WRL68 IC50 4.0 nM 10.1016/j.bmcl.2008.06.039
Homo sapiens WRL68 IC50 4.0 nM 10.1016/j.ejmech.2013.03.029
Homo sapiens WRL68 IC90 2.5 ug.mL-1 10.1016/j.bmcl.2005.10.105
Homo sapiens WSU-NHL IC50 25726.05 nM 10.6019/CHEMBL1201861
Homo sapiens XF498 GI50 3.483 nM None
Homo sapiens YT IC50 21469.06 nM 10.6019/CHEMBL1201861
Homo sapiens Z-138 Imax 99.0 % 10.1021/acs.jmedchem.2c01348
Homo sapiens Z-138 LC50 2.0 nM 10.1021/acs.jmedchem.2c01348
Homo sapiens ZR-75-1 Activity 35.0 day 10.1021/jm1000858
Homo sapiens ZR-75-1 Activity 132.0 % 10.1021/jm1000858
Homo sapiens ZR-75-1 IC50 100.0 nM 10.1016/j.bmcl.2014.08.063
Homo sapiens ZR-75-1 IC50 308.0 nM 10.1021/jm061142s
Homo sapiens ZR-75-1 Log IC50 -7.3 nM 10.1021/jm049405a
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase IC50 200.0 ug.mL-1 10.1021/np50073a012
Influenza A virus Nonstructural protein 1 Potency 11220.2 nM None
Leishmania donovani Beta tubulin IC50 1000.0 nM 10.1016/j.bmcl.2004.09.069
Leishmania donovani Beta tubulin Inhibition 80.0 % 10.1016/j.bmcl.2004.09.069
Leishmania donovani Beta tubulin Inhibition nan % 10.1016/j.bmcl.2004.05.077
Leishmania sp. Leishmania sp. IC50 35.0 nM 10.1128/aac.00355-07
Mus musculus 4T1 Activity 0.62 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 0.77 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 13.02 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 30.0 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 36.9 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 42.35 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 43.0 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 44.64 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity 61.7 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Activity nan None 10.1021/acs.jmedchem.1c00267
Mus musculus 4T1 Activity nan None 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 GI 30.5 % 10.1021/jm101577z
Mus musculus 4T1 GI nan None 10.1021/jm101577z
Mus musculus 4T1 IC50 94.0 nM 10.1021/acs.jmedchem.1c01123
Mus musculus 4T1 IC50 94.0 nM 10.1021/acs.jmedchem.8b01445
Mus musculus 4T1 IC50 200.0 nM 10.1021/jm0510676
Mus musculus 4T1 IC50 800.0 nM 10.1021/acs.jnatprod.0c01363
Mus musculus 4T1 IC50 1000.0 nM 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Inhibition 34.0 % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 Inhibition nan % 10.1021/acsmedchemlett.9b00339
Mus musculus 4T1 T/C 49.2 % 10.1016/j.ejmech.2021.113930
Mus musculus B16 Activity 32.0 % 10.1021/np800568j
Mus musculus B16 Change in cell number 75.0 % 10.1021/jm00079a019
Mus musculus B16 Change in cell number 252.0 % 10.1021/jm00079a019
Mus musculus B16 Cytotoxicity 1.0 None 10.1016/S0960-894X(97)00329-6
Mus musculus B16 ED50 0.7 uM 10.1016/S0960-894X(00)80402-3
Mus musculus B16 ED50 1.0 uM 10.1016/S0960-894X(00)80346-7
Mus musculus B16 ED50 27.0 nM 10.1016/S0960-894X(00)80346-7
Mus musculus B16 ED50 28.0 nM 10.1016/S0960-894X(01)80203-1
Mus musculus B16 ED50 28.0 nM 10.1021/jm00100a031
Mus musculus B16 ED50 31.5 nM 10.1016/S0960-894X(00)80402-3
Mus musculus B16 ED50 / ED50 (taxol) 23.0 nM 10.1016/S0960-894X(00)80469-2
Mus musculus B16 ED50 ratio 1.0 None 10.1016/0960-894X(94)85035-6
Mus musculus B16 ED50 ratio 1.0 None 10.1016/S0960-894X(01)80139-6
Mus musculus B16 ED50 ratio 1.0 None 10.1016/S0960-894X(01)80366-8
Mus musculus B16 ED50 ratio 1.0 None 10.1016/S0960-894X(01)80378-4
Mus musculus B16 ED50 ratio 1.0 None 10.1016/S0960-894X(01)80379-6
Mus musculus B16 ED50 ratio 1.0 None 10.1021/jm960505t
Mus musculus B16 GI50 10.0 nM 10.1016/j.bmcl.2008.11.067
Mus musculus B16 GI50 10.0 nM 10.1016/j.bmcl.2010.05.074
Mus musculus B16 GI50 10.0 nM 10.1016/j.ejmech.2020.112044
Mus musculus B16 IC50 0.02 ug.mL-1 10.1021/np50078a018
Mus musculus B16 IC50 0.1 ug.mL-1 10.1016/j.bmcl.2005.12.009
Mus musculus B16 IC50 0.63 ug.mL-1 10.1021/np9005579
Mus musculus B16 IC50 8.0 nM 10.1016/S0960-894X(97)10152-4
Mus musculus B16 IC50 19.0 nM 10.1021/jm00079a019
Mus musculus B16 IC50 40.0 nM 10.1016/j.bmc.2010.10.019
Mus musculus B16 IC50 80.0 nM 10.1016/j.bmcl.2006.06.007
Mus musculus B16 IC50 56000.0 nM 10.1021/np500773s
Mus musculus B16 Mitotic index 28.0 nM 10.1021/jm9703350
Mus musculus B16 Ratio 1.0 None 10.1016/0960-894X(94)00468-U
Mus musculus B16 Ratio 1.0 None 10.1016/0960-894X(95)00020-T
Mus musculus B16 Ratio 1.0 None 10.1021/jm00046a018
Mus musculus B16 Relative effect 1.0 None 10.1021/jm00079a019
Mus musculus B16-F0 Activity 60.4 % 10.1016/j.ejmech.2020.112519
Mus musculus B16-F0 Activity 63.8 % 10.1016/j.ejmech.2020.112519
Mus musculus B16-F0 IC50 21.0 nM 10.1016/j.ejmech.2020.112519
Mus musculus B16-F1 GI50 20.0 nM 10.1016/j.bmc.2020.115433
Mus musculus B16-F10 Activity 11.3 % 10.1021/acs.jmedchem.1c01123
Mus musculus B16-F10 Activity 12.5 % 10.1021/acs.jmedchem.1c01123
Mus musculus B16-F10 Activity 24.0 % 10.1021/acs.jmedchem.1c01123
Mus musculus B16-F10 Activity nan None 10.1021/acs.jmedchem.1c01123
Mus musculus B16-F10 Cytotoxicity 6.3 ng ml-1 10.1021/jm00009a009
Mus musculus B16-F10 IC50 0.0041 ug.mL-1 10.1016/S0960-894X(01)80507-2
Mus musculus B16-F10 IC50 1.0 nM 10.1021/acs.jmedchem.2c01208
Mus musculus B16-F10 IC50 530.0 nM 10.1021/acs.jmedchem.1c01123
Mus musculus B16-F10 IC50 530.0 nM 10.1021/acs.jmedchem.8b01445
Mus musculus B16-F10 IC50 8010.0 nM 10.1021/acs.jmedchem.8b01445
Mus musculus B16-F10 IC50 19140.0 nM 10.1016/j.bmc.2011.09.008
Mus musculus B16-F10 Inhibition nan % 10.1021/acs.jmedchem.8b01445
Mus musculus B16-F10 TGI 88.66 % 10.1021/acs.jmedchem.0c01837
Mus musculus Bile salt export pump Activity nan None None
Mus musculus BNL IC50 200.0 nM 10.1021/jm0510676
Mus musculus Brain Kin 6.9 10^-4ml/g/s 10.1021/jm9016637
Mus musculus CCRF S-180 Activity 3.34 g 10.1016/j.bmcl.2016.06.012
Mus musculus CCRF S-180 Activity nan None 10.1016/j.bmcl.2012.02.109
Mus musculus CCRF S-180 GI 48.9 % 10.1016/j.bmcl.2012.02.109
Mus musculus CCRF S-180 TGI 56.0 % 10.1016/j.bmcl.2016.06.012
Mus musculus CT26 IC50 10000.0 nM 10.1021/acs.jmedchem.1c01123
Mus musculus EL4 IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Mus musculus EL4 IC50 1.34 ug.mL-1 10.1021/jm020119d
Mus musculus EL4 IC50 1700.0 nM 10.1021/np500836y
Mus musculus EMT6 IC50 9.0 nM 10.1021/jm970026+
Mus musculus H22 Activity 72.1 % 10.1021/acsmedchemlett.8b00217
Mus musculus H22 Activity 90.39 % 10.1016/j.ejmech.2022.114155
Mus musculus H22 IC50 84.0 nM 10.1016/j.ejmech.2020.112308
Mus musculus H22 Inhibition 64.3 % 10.1016/j.ejmech.2020.112308
Mus musculus H22 Inhibition 64.3 % 10.1016/j.ejmech.2020.112716
Mus musculus H22 Inhibition 72.7 % 10.1016/j.ejmech.2019.04.008
Mus musculus H22 Inhibition 72.7 % 10.1016/j.ejmech.2021.113316
Mus musculus H22 TGI 47.0 % 10.1016/j.ejmech.2013.04.008
Mus musculus H22 TGI 73.85 % 10.1016/j.ejmech.2016.11.013
Mus musculus H22 TGI 74.6 % 10.1016/j.ejmech.2018.08.074
Mus musculus Intestine Ratio AUC 17.0 None 10.1124/dmd.110.034629
Mus musculus J774 ED50 0.09 uM 10.1016/S0960-894X(01)80527-8
Mus musculus J774 ED50 0.09 uM 10.1021/jm00036a009
Mus musculus J774 IC50 15.0 nM 10.1021/jm970026+
Mus musculus J774 IC50 65.6 nM 10.1016/0960-894X(95)00300-I
Mus musculus J774.2 ED50 0.016 uM 10.1016/S0960-894X(97)00337-5
Mus musculus J774.2 ED50 0.09 uM 10.1021/jm00107a042
Mus musculus J774.2 IC50 30.9 nM 10.1016/0960-894X(95)00300-I
Mus musculus J774.2 IC50 332.3 nM 10.1016/0960-894X(95)00300-I
Mus musculus L1210 Activity 0.052 uM 10.1016/j.bmcl.2007.09.054
Mus musculus L1210 Activity 3.4 uM 10.1016/j.bmcl.2007.09.054
Mus musculus L1210 IC50 0.026 ug.mL-1 10.1016/S0960-894X(97)00029-2
Mus musculus L1210 IC50 0.09 nM 10.1016/s0960-894x(02)00694-7
Mus musculus L1210 IC50 0.33 ug.mL-1 10.1016/S0960-894X(97)00029-2
Mus musculus L1210 IC50 0.33 ug.mL-1 10.1016/s0960-894x(98)00262-5
Mus musculus L1210 IC50 0.4 nM 10.1016/j.ejmech.2011.08.034
Mus musculus L1210 IC50 0.4 nM 10.1021/jm200488a
Mus musculus L1210 IC50 0.58 nM 10.1016/s0960-894x(02)00694-7
Mus musculus L1210 IC50 27.6 nM 10.1016/j.bmc.2015.02.057
Mus musculus L1210 IC50 60.0 nM 10.1016/j.bmc.2011.06.010
Mus musculus L1210 IC50 60.0 nM 10.1016/j.ejmech.2010.04.032
Mus musculus L1210 IC50 60.0 nM 10.1021/jm0307685
Mus musculus L1210 IC50 60.0 nM 10.1021/jm0605031
Mus musculus L1210 IC50 60.0 nM 10.1021/jm0708984
Mus musculus L1210 IC50 60.0 nM 10.1021/jm801338r
Mus musculus L1210 IC50 70.0 nM 10.1021/jm801338r
Mus musculus L1210 IC50 120.0 nM 10.1021/np200741x
Mus musculus L1210 IC50 5000.0 nM 10.1016/j.bmc.2011.06.010
Mus musculus L1210 IC50 5000.0 nM 10.1016/j.ejmech.2010.04.032
Mus musculus L1210 IC50 5000.0 nM 10.1021/jm0307685
Mus musculus L1210 IC50 5000.0 nM 10.1021/jm0605031
Mus musculus L1210 IC50 5000.0 nM 10.1021/jm0708984
Mus musculus L1210 IC50 6000.0 nM 10.1016/S0960-894X(01)80411-X
Mus musculus L1210 IC50 24000.0 nM 10.1021/jm00017a026
Mus musculus L1210 LD50 0.014 ug ml-1 10.1021/np9805084
Mus musculus L1210 T/C 139.0 % 10.1021/np800191t
Mus musculus L929 GI50 0.1 ug.mL-1 10.1021/np040062t
Mus musculus L929 GI50 0.1 ug.mL-1 10.1021/np060587g
Mus musculus L929 IC50 32.95 ug.mL-1 10.1016/j.bmcl.2019.126730
Mus musculus L929 IC50 nan None 10.1021/jm201121b
Mus musculus Lewis lung carcinoma cell line Activity 4.0 % 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line Activity 6.9 % 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line Activity 15.9 % 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line Activity 20.0 % 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line Activity 73.4 % 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line Activity nan None 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line FC 7.28 None 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line GI 26.2 % 10.1021/jm101577z
Mus musculus Lewis lung carcinoma cell line GI nan None 10.1021/jm101577z
Mus musculus Lewis lung carcinoma cell line IC50 10.0 nM 10.1021/acs.jmedchem.8b01590
Mus musculus Lewis lung carcinoma cell line IC50 61.0 nM 10.1016/S0960-894X(97)10152-4
Mus musculus Lewis lung carcinoma cell line IC50 189.0 nM 10.1021/acs.jmedchem.8b01445
Mus musculus Lewis lung carcinoma cell line TGI nan None 10.1021/acs.jmedchem.7b00608
Mus musculus Lewis lung carcinoma cell line TGI nan None 10.1021/acs.jmedchem.8b01590
Mus musculus M109 Efficacy 2.3 None 10.1021/jm0102607
Mus musculus M109 Efficacy 259.0 None 10.1021/jm0102607
Mus musculus M109 T/C 159.0 mg kg-1 injection-1 10.1016/0960-894X(95)00453-Z
Mus musculus M109 T/C 166.0 % 10.1016/S0960-894X(97)10142-1
Mus musculus M109 T/C 197.0 % 10.1016/S0960-894X(01)80385-1
Mus musculus M109 T/C 215.0 % 10.1016/s0960-894x(01)00066-x
Mus musculus M109 T/C 246.0 % 10.1016/s0960-894x(01)00067-1
Mus musculus M109 T/C 262.0 % 10.1016/S0960-894X(01)80385-1
Mus musculus M109 T/C 270.0 % 10.1016/S0960-894X(01)80385-1
Mus musculus M109 T/C 275.0 % 10.1016/S0960-894X(01)80385-1
Mus musculus M109 T/C 276.0 % 10.1016/S0960-894X(01)80385-1
Mus musculus Mus musculus Activity -28.1 % 10.1016/j.bmcl.2016.06.012
Mus musculus Mus musculus Activity -6.3 % 10.1021/jm200757g
Mus musculus Mus musculus Activity -5.6 % 10.1021/jm500849z
Mus musculus Mus musculus Activity -3.7 % 10.1021/jm500849z
Mus musculus Mus musculus Activity 1.1 g 10.1021/np010322w
Mus musculus Mus musculus Activity 1.4 g 10.1021/np010322w
Mus musculus Mus musculus Activity 1.7 g 10.1021/np010322w
Mus musculus Mus musculus Activity 1.8 g 10.1021/np010322w
Mus musculus Mus musculus Activity 2.5 % 10.1016/j.bmc.2017.04.012
Mus musculus Mus musculus Activity 2.8 % 10.1021/ml1001568
Mus musculus Mus musculus Activity 4.0 % 10.1021/jm301058f
Mus musculus Mus musculus Activity 4.99 % 10.1021/acs.jmedchem.7b00273
Mus musculus Mus musculus Activity 5.0 % 10.1016/j.ejmech.2018.05.003
Mus musculus Mus musculus Activity 6.2 % 10.1021/acs.jmedchem.1c00705
Mus musculus Mus musculus Activity 6.7 % 10.1021/np010322w
Mus musculus Mus musculus Activity 7.8 % 10.1021/np010322w
Mus musculus Mus musculus Activity 8.2 % 10.1021/np010322w
Mus musculus Mus musculus Activity 9.4 % 10.1021/np010322w
Mus musculus Mus musculus Activity 13.0 % 10.1073/pnas.0611340104
Mus musculus Mus musculus Activity 18.76 g 10.1016/j.bmc.2011.05.017
Mus musculus Mus musculus Activity 18.9 g 10.1016/j.ejmech.2016.11.013
Mus musculus Mus musculus Activity 19.7 g 10.1016/j.bmc.2011.05.017
Mus musculus Mus musculus Activity 19.72 g 10.1016/j.bmc.2011.05.017
Mus musculus Mus musculus Activity 20.0 % 10.1073/pnas.0611340104
Mus musculus Mus musculus Activity 20.13 g 10.1016/j.bmc.2011.05.017
Mus musculus Mus musculus Activity 20.17 g 10.1016/j.bmc.2011.05.017
Mus musculus Mus musculus Activity 20.25 g 10.1016/j.bmc.2011.05.017
Mus musculus Mus musculus Activity 46.7 % 10.1021/jm101577z
Mus musculus Mus musculus Activity 79.1 % 10.1021/jm101577z
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2007.03.041
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2013.02.002
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2011.11.083
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2012.09.076
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2016.06.012
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2016.11.020
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2017.02.008
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.02.045
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.08.074
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.1c00705
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.1c01498
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.7b01858
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.8b00416
Mus musculus Mus musculus Activity nan None 10.1021/acs.jnatprod.9b00720
Mus musculus Mus musculus Activity nan None 10.1021/acsmedchemlett.8b00217
Mus musculus Mus musculus Activity nan None 10.1021/jm101577z
Mus musculus Mus musculus Activity nan None 10.1021/jm301058f
Mus musculus Mus musculus Activity nan None 10.1021/jm301864s
Mus musculus Mus musculus Activity nan None 10.1021/jm500849z
Mus musculus Mus musculus Activity nan None 10.1021/jm800086e
Mus musculus Mus musculus Activity nan None 10.1021/jm800767c
Mus musculus Mus musculus Activity nan None 10.1021/ml1001568
Mus musculus Mus musculus Activity nan None 10.1021/np010322w
Mus musculus Mus musculus Activity nan None 10.1021/np8006556
Mus musculus Mus musculus Activity nan None 10.1073/pnas.0611340104
Mus musculus Mus musculus AUC 197.35 ng.hr.mL-1 10.1016/j.bmcl.2014.10.088
Mus musculus Mus musculus AUC 2519.06 ng.hr.mL-1 10.1016/j.bmcl.2013.07.032
Mus musculus Mus musculus AUC 8720.0 ng.hr.mL-1 10.1021/jm800767c
Mus musculus Mus musculus AUC 35320.0 ng.hr.mL-1 10.1021/jm800767c
Mus musculus Mus musculus Body weight change 7.8 % 10.1016/s0960-894x(02)00694-7
Mus musculus Mus musculus Body weight change 16.9 % 10.1016/s0960-894x(02)00694-7
Mus musculus Mus musculus Cmax 39.93 nM 10.1016/j.bmcl.2014.10.088
Mus musculus Mus musculus Cmax 10600.0 nM 10.1016/j.bmcl.2013.07.032
Mus musculus Mus musculus C/T 0.0 None 10.1021/jm0102607
Mus musculus Mus musculus C/T 1.0 None 10.1021/jm0102607
Mus musculus Mus musculus Death 0.0 None 10.1021/jm0203884
Mus musculus Mus musculus F 0.23 % 10.1021/jm800767c
Mus musculus Mus musculus F 100.0 % 10.1021/jm800767c
Mus musculus Mus musculus Final average tumor weight 0.0 mg 10.1021/jm00079a019
Mus musculus Mus musculus Final average tumor weight 0.09 mg 10.1021/jm00079a019
Mus musculus Mus musculus Initial average tumor weight 0.58 mg 10.1021/jm00079a019
Mus musculus Mus musculus Initial average tumor weight 0.6 mg 10.1021/jm00079a019
Mus musculus Mus musculus Initial average tumor weight 0.74 mg 10.1021/jm00079a019
Mus musculus Mus musculus Initial average tumor weight 0.79 mg 10.1021/jm00079a019
Mus musculus Mus musculus Initial average tumor weight 0.81 mg 10.1021/jm00079a019
Mus musculus Mus musculus LCK 1.3 None 10.1021/jm0102607
Mus musculus Mus musculus LCK 2.8 None 10.1021/jm0102607
Mus musculus Mus musculus LCK 6.1 None 10.1021/jm0102607
Mus musculus Mus musculus LCK 273.0 None 10.1021/jm0102607
Mus musculus Mus musculus Log kill 0.7 None 10.1021/jm0005149
Mus musculus Mus musculus Log kill 1.0 None 10.1021/jm0005149
Mus musculus Mus musculus Log kill 1.2 None 10.1021/jm0005149
Mus musculus Mus musculus Log kill 2.8 None 10.1021/jm0005149
Mus musculus Mus musculus Log kill 4.2 None 10.1021/jm0203884
Mus musculus Mus musculus Max T/C 190.0 None 10.1016/S0960-894X(00)80348-0
Mus musculus Mus musculus Max T/C 240.0 None 10.1016/S0960-894X(00)80348-0
Mus musculus Mus musculus Max T/C 270.0 None 10.1016/S0960-894X(00)80348-0
Mus musculus Mus musculus Max T/C 276.0 None 10.1016/S0960-894X(00)80075-X
Mus musculus Mus musculus MCHC 365000.0 ug.mL-1 10.1021/jm990514c
Mus musculus Mus musculus MTD 15.0 mg kg-1 10.1039/C0MD00179A
Mus musculus Mus musculus MTD 30.0 mg kg-1 10.1016/j.bmcl.2016.06.012
Mus musculus Mus musculus MTD 40.6 mg kg-1 10.1016/s0960-894x(02)00153-1
Mus musculus Mus musculus No. of survivors 3.0 None 10.1021/jm00079a019
Mus musculus Mus musculus No. of survivors 5.0 None 10.1021/jm00079a019
Mus musculus Mus musculus No. of survivors 6.0 None 10.1021/jm00079a019
Mus musculus Mus musculus Platelet 1.04 10e6 ul-1 10.1021/jm990514c
Mus musculus Mus musculus RBC 8.33 10e3 ul-1 10.1021/jm990514c
Mus musculus Mus musculus Relative antitumor activity 1.0 None 10.1021/jm00079a019
Mus musculus Mus musculus Survivors 0.0 % 10.1021/jm990514c
Mus musculus Mus musculus T1/2 0.56 hr 10.1021/jm800767c
Mus musculus Mus musculus T1/2 0.68 hr 10.1021/jm800767c
Mus musculus Mus musculus T1/2 2.26 hr 10.1016/j.bmcl.2013.07.032
Mus musculus Mus musculus T/C -84.0 % 10.1021/jm00079a019
Mus musculus Mus musculus T/C 0.0 % 10.1021/jm0203884
Mus musculus Mus musculus T/C 48.0 % 10.1016/S0960-894X(97)10152-4
Mus musculus Mus musculus T/C 145.0 None 10.1016/s0960-894x(00)00242-0
Mus musculus Mus musculus T/C 150.0 % 10.1016/s0960-894x(02)00153-1
Mus musculus Mus musculus T/C 161.0 % 10.1021/jm9703350
Mus musculus Mus musculus T/C nan None 10.1021/jm00079a019
Mus musculus Mus musculus Tmax 1.0 hr 10.1016/j.bmcl.2014.10.088
Mus musculus Mus musculus Tumor inhibition 71.4 % 10.1016/s0960-894x(02)00694-7
Mus musculus Mus musculus Tumor inhibition 78.02 % 10.1016/s0960-894x(02)00694-7
Mus musculus Mus musculus WBC 13.4 10e3 ul-1 10.1021/jm990514c
Mus musculus Mus musculus Weight loss -5.0 % 10.1021/jm0203884
Mus musculus NIH3T3 IC50 25.0 nM 10.1016/j.ejmech.2018.11.004
Mus musculus NIH3T3 IC50 1290.0 nM 10.1016/j.bmcl.2006.06.007
Mus musculus NIH3T3 IC50 4875.0 nM 10.1016/j.ejmech.2018.11.004
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 1122.0 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 2238.7 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 5011.9 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 6309.6 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 14125.4 nM None
Mus musculus P388 Activity 0.038 uM 10.1016/j.bmcl.2007.09.054
Mus musculus P388 Activity 1.0 None 10.1016/0960-894X(95)00020-T
Mus musculus P388 Activity 3.4 uM 10.1016/j.bmcl.2007.09.054
Mus musculus P388 Cytotoxicity 11.0 ng ml-1 10.1021/jm00009a009
Mus musculus P388 FR 11.0 None 10.1016/s0960-894x(00)00150-5
Mus musculus P388 GI50 0.00293 ug.mL-1 10.1016/s0960-894x(02)00891-0
Mus musculus P388 GI50 5.689 nM None
Mus musculus P388 GI50 16.0 nM 10.1016/s0960-894x(98)00477-6
Mus musculus P388 IC50 0.01 ug.mL-1 10.1016/S0960-894X(97)00071-1
Mus musculus P388 IC50 0.03 ug.mL-1 10.1021/np9607159
Mus musculus P388 IC50 0.046 ug.mL-1 10.1016/S0960-894X(01)80507-2
Mus musculus P388 IC50 0.05 ug.mL-1 10.1021/np50089a022
Mus musculus P388 IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
Mus musculus P388 IC50 0.2 ug.mL-1 10.1016/s0960-894x(98)00005-5
Mus musculus P388 IC50 0.2 ug.mL-1 10.1021/np400110g
Mus musculus P388 IC50 0.27 ug.mL-1 10.1021/jm00107a017
Mus musculus P388 IC50 2.27 ug.mL-1 10.1021/jm020119d
Mus musculus P388 IC50 10.0 nM 10.1016/j.bmcl.2006.07.020
Mus musculus P388 IC50 10.0 nM 10.1016/j.bmcl.2008.02.029
Mus musculus P388 IC50 16.0 nM 10.1016/s0960-894x(00)00150-5
Mus musculus P388 IC50 20.0 nM 10.1021/np010322w
Mus musculus P388 IC50 22.0 nM 10.1021/jm060593+
Mus musculus P388 IC50 40.0 nM 10.1016/j.bmc.2011.06.010
Mus musculus P388 IC50 40.0 nM 10.1016/j.ejmech.2010.04.032
Mus musculus P388 IC50 40.0 nM 10.1021/jm0605031
Mus musculus P388 IC50 40.0 nM 10.1021/jm0708984
Mus musculus P388 IC50 45.0 ug.mL-1 10.1021/np50121a005
Mus musculus P388 IC50 50.0 nM 10.1021/jm801338r
Mus musculus P388 IC50 70.0 nM 10.1021/jm801338r
Mus musculus P388 IC50 170.0 nM 10.1016/s0960-894x(00)00150-5
Mus musculus P388 IC50 930.0 nM 10.1021/np070208z
Mus musculus P388 IC50 930.0 nM 10.1021/np0704708
Mus musculus P388 IC50 5000.0 nM 10.1016/j.bmc.2011.06.010
Mus musculus P388 IC50 5000.0 nM 10.1016/j.ejmech.2010.04.032
Mus musculus P388 IC50 5000.0 nM 10.1021/jm0605031
Mus musculus P388 IC50 5000.0 nM 10.1021/jm0708984
Mus musculus P388 IC50 6000.0 nM 10.1016/S0960-894X(01)80411-X
Mus musculus P388 IC50 21877616.24 nM 10.1016/S0960-894X(97)00439-3
Mus musculus P388 Ratio IC50 55.0 None 10.1021/jm060593+
Mus musculus P388 T/C 104.0 % 10.1021/np50056a017
Mus musculus P388 T/C 132.0 % 10.1021/np50078a018
Mus musculus P388 T/C 137.0 % 10.1021/np50056a017
Mus musculus P388 T/C 147.0 % 10.1021/np50056a017
Mus musculus P388 T/C 150.0 % 10.1021/np50078a018
Mus musculus P388 T/C 152.0 % 10.1021/np50015a013
Mus musculus P388 T/C 155.0 % 10.1021/np50078a018
Mus musculus P388 T/C 156.0 % 10.1021/np50056a017
Mus musculus P388/ADR GI50 605.34 nM None
Mus musculus P388/ADR GI50 15000.0 nM 10.1016/s0960-894x(98)00477-6
Mus musculus P388/ADR IC50 30.0 nM 10.1021/jm060593+
Mus musculus P388/ADR IC50 40.0 nM 10.1021/jm0307685
Mus musculus P388/ADR IC50 1636.0 nM 10.1021/jm060593+
Mus musculus P388/ADR IC50 5000.0 nM 10.1021/jm0307685
Mus musculus P388/ADR IC50 nan None 10.1021/jm060593+
Mus musculus P-glycoprotein 3 Activity nan None 10.1073/pnas.94.5.2031
Mus musculus Plasma Ratio AUC 6.0 None 10.1124/dmd.110.034629
Mus musculus Plasma T1/2 30.1 hr 10.1016/j.bmcl.2007.04.058
Mus musculus RAW264.7 Activity 13.3 % 10.1039/C0MD00235F
Mus musculus RAW264.7 Activity 39.2 % 10.1039/C0MD00235F
Mus musculus RAW264.7 Activity 39.3 % 10.1039/C0MD00235F
Mus musculus RAW264.7 Activity 49.9 % 10.1039/C0MD00235F
Mus musculus RAW264.7 IC50 5000.0 nM 10.1021/acs.jnatprod.6b00893
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC99 40.0 uM 10.1021/jm050920y
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus Activity -23.0 % 10.1021/jm0304111
Oryctolagus cuniculus Oryctolagus cuniculus Activity -11.0 % 10.1021/jm0304111
Oryctolagus cuniculus Oryctolagus cuniculus Stenosis 22.6 % 10.1021/jm0304111
Paracentrotus lividus Paracentrotus lividus EC 0.5 uM 10.1021/acs.jnatprod.5b00124
Paracentrotus lividus Paracentrotus lividus EC 2.0 uM 10.1021/acs.jnatprod.5b00124
Paracentrotus lividus Paracentrotus lividus EC 10.0 uM 10.1021/acs.jnatprod.5b00124
Parastagonospora nodorum Parastagonospora nodorum Activity 91.0 % 10.1016/j.bmc.2015.08.038
Photinus pyralis Luciferin 4-monooxygenase Potency 8492.1 nM None
Photinus pyralis Luciferin 4-monooxygenase Potency 15848.9 nM None
Plasmodium falciparum Plasmodium falciparum IC50 0.07 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 0.09 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 0.15 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 0.23 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 0.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1.78 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 3.0 nM 10.1016/j.bmcl.2018.02.051
Plasmodium falciparum Plasmodium falciparum IC50 63.1 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 79.43 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 158.49 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 251.19 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1584.89 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.7b00247
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.7b00579
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.8b00135
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.8b00379
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.9b00724
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/acs.jnatprod.9b01064
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np200499d
Plasmodium falciparum Plasmodium falciparum Potency 58.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 73.8 nM None
Plasmodium falciparum Plasmodium falciparum Potency 104.2 nM None
Plasmodium falciparum Plasmodium falciparum Potency 116.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 134.6 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.bmcl.2016.11.025
Puccinia triticina Puccinia triticina Activity 95.0 % 10.1016/j.bmc.2015.08.038
Rattus norvegicus A10 IC50 38.0 nM 10.1021/jm900016t
Rattus norvegicus A10 IC50 nan None 10.1021/np500768s
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Brain Drug uptake nan None 10.1124/dmd.112.046508
Rattus norvegicus Brain Fu 0.012 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Kp 9.03 None 10.1124/dmd.110.035998
Rattus norvegicus Brain Vd 769.0 L.kg-1 10.1124/dmd.110.035998
Rattus norvegicus Brain Vdu 769.0 ml 10.1021/jm901036q
Rattus norvegicus C6 Activity nan None 10.1021/jm201428a
Rattus norvegicus C6 LC50 23.0 nM 10.1021/np960144k
Rattus norvegicus C6 Ratio IC50 112.0 None 10.1021/jm800086e
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Kidney Drug uptake nan None 10.1124/dmd.112.046508
Rattus norvegicus Liver Drug uptake nan None 10.1124/dmd.112.046508
Rattus norvegicus Liver IC50 nan None 10.1002/hep.27206
Rattus norvegicus LT12 tumor cell line IC50 6.0 nM 10.1021/jm0307685
Rattus norvegicus LT12 tumor cell line IC50 400.0 nM 10.1021/jm0307685
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus NRK IC50 nan None 10.1016/j.ejmech.2014.10.013
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Potency 3548.1 nM None
Rattus norvegicus PC-12 GI50 0.539 ug.mL-1 10.1016/s0960-894x(02)00891-0
Rattus norvegicus Peripheral myelin protein 22 Potency 510.3 nM None
Rattus norvegicus Plasma Cp(f) 0.016 uM 10.1021/jm901036q
Rattus norvegicus Plasma Fu 0.05 None 10.1021/jm901036q
Rattus norvegicus Plasma K(p,uu,CSF) nan None 10.1021/jm901036q
Rattus norvegicus Plasma T1/2 18.2 hr 10.1016/j.bmcl.2007.04.058
Rattus norvegicus Rattus norvegicus AUC 88.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 113.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 171.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 172.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 303.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 375.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 622.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 746.0 ng.hr.mL-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus AUC 10161.65 ng.hr.mL-1 10.1016/j.bmcl.2013.07.032
Rattus norvegicus Rattus norvegicus CL 66.67 mL.min-1.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus CL 101.67 mL.min-1.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus CL 111.67 mL.min-1.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus CL 151.67 mL.min-1.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Cmax 35.13 nM 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Cmax 46.84 nM 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Cmax 169.81 nM 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Cmax 176.83 nM 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Cmax 20400.0 nM 10.1016/j.bmcl.2013.07.032
Rattus norvegicus Rattus norvegicus F 12.0 % 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus F 13.0 % 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus F 27.0 % 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus F 47.0 % 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 3.4 hr 10.1016/j.bmcl.2013.07.032
Rattus norvegicus Rattus norvegicus T1/2 4.4 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 5.3 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 6.4 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 7.2 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 8.1 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 9.4 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 10.0 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus T1/2 12.2 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Tmax 0.8 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Tmax 0.9 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Tmax 1.2 hr 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Vdss 28.6 L.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Vdss 29.1 L.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Vdss 30.3 L.kg-1 10.1124/dmd.112.046508
Rattus norvegicus Rattus norvegicus Vdss 38.1 L.kg-1 10.1124/dmd.112.046508
Rattus norvegicus RH7777 IC50 nan nM 10.1021/jm049208b
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 4228.4 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 70794.6 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus WALKER IC50 150.0 nM 10.1016/S0960-894X(97)10152-4
Rattus norvegicus YOSHIDA IC50 7.9 nM 10.1016/S0960-894X(97)10152-4
Saccharomyces cerevisiae Saccharomyces cerevisiae IC50 100000.0 nM 10.1016/j.bmcl.2020.127285
Saccharomyces cerevisiae Saccharomyces cerevisiae IZ 0.0 mm 10.1016/j.ejmech.2010.07.050
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 17.79 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 23.17 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.12 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.17 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 8.47 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index -0.0235 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmcl.2016.11.025
Streptococcus mutans Streptococcus mutans Activity nan None 10.1016/j.bmcl.2016.11.025
Sus scrofa Calpain 1 Ki nan None 10.1016/j.bmc.2020.115433
Sus scrofa LLC-PK1 TC50 4.39 uM 10.1021/acs.jmedchem.5b01380
Sus scrofa Sus scrofa ED50 0.86 uM 10.1016/s0960-894x(97)10189-5
Sus scrofa Sus scrofa Ratio 1.0 None 10.1021/jm00107a017
Sus scrofa Sus scrofa Tubulin polymerization 49.0 % 10.1016/s0960-894x(00)00555-2
Sus scrofa Tubulin Activity 6.3 % 10.1016/j.ejmech.2013.01.007
Sus scrofa Tubulin Activity 23.8 % 10.1016/j.ejmech.2013.01.007
Sus scrofa Tubulin Activity 32.0 % 10.1021/np8004858
Sus scrofa Tubulin Activity 100.0 % 10.1021/np8004858
Sus scrofa Tubulin Activity nan None 10.1016/j.bmc.2012.03.035
Sus scrofa Tubulin Activity nan None 10.1016/j.bmcl.2019.126777
Sus scrofa Tubulin Activity nan None 10.1016/j.ejmech.2016.04.001
Sus scrofa Tubulin Activity nan None 10.1016/j.ejmech.2019.03.031
Sus scrofa Tubulin Activity nan None 10.1016/j.ejmech.2019.111728
Sus scrofa Tubulin Activity nan None 10.1021/acs.jmedchem.6b00777
Sus scrofa Tubulin Activity nan None 10.1021/acs.jmedchem.9b01815
Sus scrofa Tubulin Activity nan None 10.1021/acs.jmedchem.9b02097
Sus scrofa Tubulin Activity nan None 10.1021/jm070834t
Sus scrofa Tubulin Binding ratio 1.0 None 10.1016/0960-894X(95)00453-Z
Sus scrofa Tubulin EC50 520.0 nM 10.1021/ml300149z
Sus scrofa Tubulin FC 1.3 None 10.1039/d1md00392e
Sus scrofa Tubulin Inhibition nan % 10.1016/j.ejmech.2019.01.011
Sus scrofa Tubulin Inhibition nan % 10.1016/j.ejmech.2019.111584
Sus scrofa Tubulin TIME 0.2667 hr 10.1021/acs.jmedchem.5b01971
Sus scrofa Tubulin Vmax 84.0 milli optical density/minute 10.1016/j.bmc.2019.07.048
Sus scrofa Tubulin alpha chain Concentration 10.0 uM 10.1016/S0960-894X(97)00029-2
Sus scrofa Tubulin alpha chain ED50 0.4 uM 10.1016/s0960-894x(00)00031-7
Sus scrofa Tubulin alpha chain ED50 0.4 uM 10.1021/jm001103v
Sus scrofa Tubulin alpha chain ED50 0.93 uM 10.1021/jm00044a020
Sus scrofa Tubulin alpha chain ED50 ratio 1.0 None 10.1016/0960-894X(94)85035-6
Sus scrofa Tubulin alpha chain ED50 ratio 1.0 None 10.1016/S0960-894X(01)80139-6
Sus scrofa Tubulin alpha chain ED50 ratio 1.0 None 10.1016/S0960-894X(01)80366-8
Sus scrofa Tubulin alpha chain Initial rate ratio 1.0 None 10.1016/S0960-894X(00)80075-X
Sus scrofa Tubulin alpha chain Ratio 1.0 None 10.1016/0960-894X(94)80020-0
Sus scrofa Tubulin alpha chain Ratio 1.0 None 10.1016/S0960-894X(97)10142-1
Sus scrofa Tubulin alpha chain Ratio 1.0 None 10.1021/jm00012a029
Sus scrofa Tubulin alpha chain Tubulin polymerization 1.0 None 10.1016/s0960-894x(01)00066-x
Sus scrofa Tubulin alpha chain Tubulin polymerization 1.0 None 10.1016/s0960-894x(01)00067-1
Sus scrofa Tubulin beta chain Activity nan None 10.1016/j.bmc.2012.10.009
Sus scrofa Tubulin beta chain Activity nan None 10.1016/j.bmcl.2013.02.016
Sus scrofa Tubulin beta chain Activity nan None 10.1021/jm3012728
Toxoplasma gondii Toxoplasma gondii IC50 1000.0 nM 10.1128/aac.00355-07
Transmissible gastroenteritis virus Transmissible gastroenteritis virus EC50 nan None 10.1021/jm300705j
Trypanosoma brucei Trypanosoma brucei IC50 4.6 nM 10.1016/j.bmcl.2012.07.023
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1000.0 nM 10.1021/jm4004279
Trypanosoma cruzi Cruzipain Potency 5011.9 nM None
Trypanosoma cruzi Cruzipain Potency 12589.3 nM None
None ADMET Activity -20.9 % 10.1021/acs.jmedchem.1c01451
None ADMET Activity -10.9 % 10.1021/acs.jmedchem.1c01451
None ADMET Activity -2.79 % 10.1021/acs.jmedchem.1c01451
None ADMET Activity 0.16 mg/dl 10.1016/j.ejmech.2019.111584
None ADMET Activity 4.0 % 10.1021/acs.jmedchem.1c00705
None ADMET Activity 5.0 % 10.1021/acs.jmedchem.0c01826
None ADMET Activity 8.7 % 10.1021/acs.jmedchem.1c00705
None ADMET Activity 11.0 % None
None ADMET Activity 12.2 % 10.1021/acs.jmedchem.1c01451
None ADMET Activity 19.0 mg/dl 10.1016/j.ejmech.2019.111584
None ADMET Activity 23.5 % 10.1016/j.ejmech.2010.11.011
None ADMET Activity 28.0 % 10.1021/jm201428a
None ADMET Activity 28.0 % None
None ADMET Activity 30.0 % 10.1021/acs.jmedchem.8b01742
None ADMET Activity 36.76 % 10.1016/j.ejmech.2010.11.011
None ADMET Activity 39.75 % 10.1016/j.ejmech.2010.11.011
None ADMET Activity 41.5 % 10.1039/C0MD00235F
None ADMET Activity 48.4 IU/L 10.1016/j.ejmech.2019.111584
None ADMET Activity 65.4 % 10.1039/C0MD00235F
None ADMET Activity 66.5 % 10.1039/C0MD00235F
None ADMET Activity 71.9 % 10.1039/C0MD00235F
None ADMET Activity 102.8 IU/L 10.1016/j.ejmech.2019.111584
None ADMET Activity nan None 10.1016/j.bmc.2009.05.006
None ADMET Activity nan None 10.1016/j.bmc.2021.116072
None ADMET Activity nan None 10.1016/j.bmcl.2011.01.111
None ADMET Activity nan None 10.1016/j.bmcl.2021.127923
None ADMET Activity nan None 10.1016/j.ejmech.2018.11.070
None ADMET Activity nan None 10.1016/j.ejmech.2019.04.005
None ADMET Activity nan None 10.1016/j.ejmech.2019.04.008
None ADMET Activity nan None 10.1016/j.ejmech.2020.112181
None ADMET Activity nan None 10.1016/j.ejmech.2020.112519
None ADMET Activity nan None 10.1016/j.ejmech.2020.112716
None ADMET Activity nan None 10.1016/j.ejmech.2020.113050
None ADMET Activity nan None 10.1016/j.ejmech.2021.113316
None ADMET Activity nan None 10.1016/j.ejmech.2022.114155
None ADMET Activity nan None 10.1016/j.ejmech.2022.114372
None ADMET Activity nan None 10.1021/acs.jmedchem.0c00408
None ADMET Activity nan None 10.1021/acs.jmedchem.0c01477
None ADMET Activity nan None 10.1021/acs.jmedchem.0c01826
None ADMET Activity nan None 10.1021/acs.jmedchem.1c00705
None ADMET Activity nan None 10.1021/acs.jmedchem.1c00966
None ADMET Activity nan None 10.1021/acs.jmedchem.1c01451
None ADMET Activity nan None 10.1021/acs.jmedchem.1c01912
None ADMET Activity nan None 10.1021/acs.jmedchem.1c02159
None ADMET Activity nan None 10.1021/acs.jmedchem.2c00549
None ADMET Activity nan None 10.1021/acs.jmedchem.2c01391
None ADMET Activity nan None 10.1021/acs.jmedchem.2c01595
None ADMET Activity nan None 10.1021/acs.jmedchem.6b00158
None ADMET Activity nan None 10.1021/acs.jmedchem.6b00943
None ADMET Activity nan None 10.1021/acs.jmedchem.8b00672
None ADMET Activity nan None 10.1021/acs.jmedchem.8b01424
None ADMET Activity nan None 10.1021/acs.jmedchem.8b01742
None ADMET Activity nan None 10.1021/acs.jmedchem.8b01755
None ADMET Activity nan None 10.1021/acs.jnatprod.9b00720
None ADMET Activity nan None 10.1021/jm201428a
None ADMET Activity nan None None
None ADMET AUC 308.5 ng.hr.mL-1 10.1021/acs.jmedchem.0c01826
None ADMET AUC 610.89 ng.hr.mL-1 10.1016/j.ejmech.2022.114231
None ADMET AUC 610.89 ng.hr.mL-1 10.1021/acs.jmedchem.1c00246
None ADMET AUC 1734.95 ng.hr.mL-1 10.1016/j.ejmech.2022.114231
None ADMET AUC 1734.95 ng.hr.mL-1 10.1021/acs.jmedchem.1c00246
None ADMET AUC 2728.1 ng.hr.mL-1 10.1021/acs.jmedchem.0c01826
None ADMET AUC 3131.51 ng.hr.mL-1 10.1016/j.ejmech.2022.114231
None ADMET AUC 3756.5 ng.hr.mL-1 10.1021/acs.jmedchem.0c01826
None ADMET AUC 4488.38 ng.hr.mL-1 10.1021/acs.jmedchem.1c00246
None ADMET AUCt 46.62 nmol/g.hr 10.1021/acs.jmedchem.6b01704
None ADMET BPR 0.28 None 10.1021/jm901036q
None ADMET CC50 0.1279 ug.mL-1 10.1016/j.bmcl.2016.05.093
None ADMET CC50 0.1374 ug.mL-1 10.1016/j.bmcl.2016.05.093
None ADMET CC50 1.85 ug.mL-1 10.1016/j.bmcl.2016.05.093
None ADMET CC50 nan None 10.1016/j.ejmech.2010.01.051
None ADMET CC50 nan None 10.1016/j.ejmech.2010.09.061
None ADMET CL 2.1 L/hr 10.1021/acs.jmedchem.0c01826
None ADMET CL 6.4 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL/F 2.88 L/hr 10.1016/j.ejmech.2022.114231
None ADMET CL/F 2.88 L/hr 10.1021/acs.jmedchem.1c00246
None ADMET CL/F 4.43 L/hr 10.1021/acs.jmedchem.1c00246
None ADMET CL/F 6.18 L/hr 10.1016/j.ejmech.2022.114231
None ADMET CL/F 32.74 L/hr 10.1016/j.ejmech.2022.114231
None ADMET CL/F 32.74 L/hr 10.1021/acs.jmedchem.1c00246
None ADMET Cmax 4.85 nmol/g 10.1021/acs.jmedchem.6b01704
None ADMET Cmax 131.28 nM 10.1016/j.ejmech.2022.114231
None ADMET Cmax 148.96 nM 10.1021/acs.jmedchem.0c01826
None ADMET Cmax 273.09 nM 10.1021/acs.jmedchem.1c00246
None ADMET Cmax 763.89 nM 10.1016/j.ejmech.2022.114231
None ADMET Cmax 998.57 nM 10.1021/acs.jmedchem.1c00246
None ADMET Cmax 1084.29 nM 10.1016/j.ejmech.2022.114231
None ADMET Cmax 1084.29 nM 10.1021/acs.jmedchem.1c00246
None ADMET Cmax 1468.52 nM 10.1021/acs.jmedchem.0c01826
None ADMET Drugabsorption nan None 10.1021/acs.jmedchem.0c01826
None ADMET Drug excretion 0.0 % 10.1124/dmd.112.046508
None ADMET Drug excretion 0.1 % 10.1124/dmd.112.046508
None ADMET Drug excretion 0.14 % 10.1124/dmd.112.046508
None ADMET Drug excretion 0.2 % 10.1124/dmd.112.046508
None ADMET Drug excretion 0.21 % 10.1124/dmd.112.046508
None ADMET Drug excretion 0.5 % 10.1124/dmd.112.046508
None ADMET Drug excretion 1.0 % 10.1124/dmd.112.046508
None ADMET Drug excretion 2.0 % 10.1124/dmd.112.046508
None ADMET Drug excretion 2.3 % 10.1124/dmd.112.046508
None ADMET Drug excretion 2.8 % 10.1124/dmd.112.046508
None ADMET Drug excretion 3.1 % 10.1124/dmd.112.046508
None ADMET Drug excretion 4.5 % 10.1124/dmd.112.046508
None ADMET Drugexcretion nan None 10.1021/acs.jmedchem.0c01826
None ADMET Drug metabolism 1.0 fmol/ug 10.1021/acs.jmedchem.1c00404
None ADMET Drug metabolism 17.0 % 10.1021/acs.jmedchem.1c00404
None ADMET Drug metabolism 55.0 % 10.1021/acs.jmedchem.1c00404
None ADMET Drug metabolism 67.0 % 10.1021/acs.jmedchem.1c00404
None ADMET Drug metabolism 83.0 % 10.1021/acs.jmedchem.1c00404
None ADMET Drug metabolism nan None 10.1021/acs.jmedchem.1c00404
None ADMET Drug uptake 0.5 % 10.1021/jm800767c
None ADMET Drug uptake 2250.0 ng/g 10.1021/acs.jmedchem.1c00705
None ADMET Drug uptake 6472.0 ng/g 10.1021/acs.jmedchem.1c00705
None ADMET Drug uptake nan None 10.1016/j.ejmech.2020.113050
None ADMET Drug uptake nan None 10.1021/acs.jmedchem.0c01826
None ADMET Drug uptake nan None 10.1021/acs.jmedchem.1c00404
None ADMET ED50 23.0 uM 10.1021/np3007588
None ADMET eLog D 4.45 None 10.1021/jm0200409
None ADMET F 3.4 % 10.1021/acs.jmedchem.0c01826
None ADMET F 8.8 % 10.1016/j.ejmech.2022.114231
None ADMET F 8.8 % 10.1021/acs.jmedchem.1c00246
None ADMET F 41.3 % 10.1021/acs.jmedchem.0c01826
None ADMET F 45.1 % 10.1016/j.ejmech.2022.114231
None ADMET F 64.68 % 10.1021/acs.jmedchem.1c00246
None ADMET F 100.0 % 10.1016/j.ejmech.2022.114231
None ADMET F 100.0 % 10.1021/acs.jmedchem.1c00246
None ADMET FC 2.0 None 10.1021/acs.jmedchem.6b01704
None ADMET Fraction ionised 0.0 None 10.1021/jm0200409
None ADMET Fu 0.005 None 10.1021/jm0200409
None ADMET Fu 0.03 None 10.1021/jm0200409
None ADMET Fu 0.07 None 10.1021/jm030408h
None ADMET GI nan None 10.1021/jm301058f
None ADMET GI50 0.0038 ug.mL-1 10.1016/j.bmcl.2016.02.043
None ADMET GI50 0.004 ug.mL-1 10.1039/C5MD00057B
None ADMET GI50 0.026 ug.mL-1 10.1039/C5MD00404G
None ADMET GI50 0.1279 ug.mL-1 10.1016/j.bmcl.2015.08.006
None ADMET GI50 0.1279 ug.mL-1 10.1016/j.bmcl.2016.03.045
None ADMET GI50 0.1374 ug.mL-1 10.1016/j.bmcl.2016.03.045
None ADMET GI50 0.1374 ug.mL-1 10.1039/C5MD00404G
None ADMET GI50 0.14 ug.mL-1 10.1039/C5MD00057B
None ADMET GI50 5.21 ug.mL-1 10.1016/j.bmcl.2016.02.056
None ADMET GI50 10.0 nM 10.1016/j.ejmech.2016.02.059
None ADMET GI50 13.7 nM 10.1016/j.bmc.2009.01.024
None ADMET GI50 nan None 10.1016/j.ejmech.2010.11.013
None ADMET GI90 0.026 ug ml-1 10.1016/j.bmcl.2016.02.056
None ADMET GI90 0.07 ug ml-1 10.1039/C5MD00057B
None ADMET GI90 0.078 ug ml-1 10.1016/j.bmcl.2016.02.043
None ADMET GI90 5.715 ug ml-1 10.1016/j.bmcl.2015.08.006
None ADMET GI90 5.715 ug ml-1 10.1016/j.bmcl.2016.03.045
None ADMET GI90 5.814 ug ml-1 10.1016/j.bmcl.2016.03.045
None ADMET GI90 5.82 ug ml-1 10.1039/C5MD00057B
None ADMET IC50 0.0015 ug.mL-1 10.1016/S0960-894X(97)00029-2
None ADMET IC50 0.0088 ug.mL-1 10.1016/S0960-894X(97)00029-2
None ADMET IC50 0.034 ug.mL-1 10.1016/j.bmcl.2006.09.068
None ADMET IC50 0.7 ug.mL-1 10.1016/j.bmc.2014.04.025
None ADMET IC50 1.1 nM 10.1016/j.bmcl.2005.03.018
None ADMET IC50 3.9 nM 10.1016/j.bmcl.2010.07.100
None ADMET IC50 4.7 nM 10.1021/acs.jmedchem.5b01971
None ADMET IC50 6.0 nM 10.1021/jm900016t
None ADMET IC50 21.0 nM 10.1021/jm900016t
None ADMET IC50 23.3 nM 10.1021/jm061142s
None ADMET IC50 30.0 nM 10.1016/j.bmc.2009.07.051
None ADMET IC50 34.0 nM 10.1021/np050417o
None ADMET IC50 40.0 nM 10.1016/j.bmcl.2007.04.030
None ADMET IC50 40.0 nM 10.1021/np040072u
None ADMET IC50 40.0 nM 10.1021/np0680073
None ADMET IC50 46.8 nM 10.1021/np0600447
None ADMET IC50 51.8 nM 10.1016/j.bmcl.2014.03.011
None ADMET IC50 580.0 nM 10.1016/j.bmcl.2015.01.056
None ADMET IC50 580.0 nM 10.1021/np400600c
None ADMET IC50 580.0 nM 10.1021/np500626x
None ADMET IC50 1100.0 nM 10.1021/np5003498
None ADMET IC50 1500.0 nM 10.1016/j.bmcl.2005.03.018
None ADMET IC50 2320.0 nM 10.1016/j.bmc.2015.11.007
None ADMET IC50 4200.0 nM 10.1021/np5009569
None ADMET IC50 5000.0 nM 10.1016/j.bmcl.2013.07.032
None ADMET IC50 7140.0 nM 10.1016/j.ejmech.2012.07.047
None ADMET IC50 7140.0 nM 10.1016/j.ejmech.2012.07.051
None ADMET IC50 7170.0 nM 10.1016/j.ejmech.2011.03.050
None ADMET IC50 10000.0 nM 10.1021/jm061142s
None ADMET IC50 14300.0 nM 10.1016/j.bmcl.2014.10.088
None ADMET IC50 15990.0 nM 10.1021/jm8006257
None ADMET IC50 16000.0 nM 10.1016/j.ejmech.2014.11.068
None ADMET IC50 19300.0 nM 10.1021/acs.jnatprod.5b00532
None ADMET IC50 20010.0 nM 10.1016/j.bmcl.2015.04.051
None ADMET IC50 23000.0 nM 10.1021/np3007414
None ADMET IC50 23000.0 nM 10.1021/np400567c
None ADMET IC50 23000.0 nM 10.1021/np5002785
None ADMET IC50 27000.0 nM 10.1021/np900722j
None ADMET IC50 38000.0 nM 10.1016/j.bmcl.2014.11.083
None ADMET IC50 40000.0 nM 10.1021/np068066g
None ADMET IC50 106200.0 nM 10.1016/j.bmc.2011.05.017
None ADMET IC50 nan None 10.1021/np500836y
None ADMET IC50 nan None 10.1039/C4MD00573B
None ADMET K(p,uu,brain) 0.007 None 10.1021/jm901036q
None ADMET LC50 nan None 10.1016/j.ejmech.2010.11.013
None ADMET log(1/C) 7.48 None 10.1016/j.ejmech.2008.02.041
None ADMET log(1/C) 7.52 None 10.1016/j.ejmech.2008.02.041
None ADMET MRT 7.8 hr 10.1124/dmd.108.020479
None ADMET Papp 0.09 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 0.3 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 0.4 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 1.02 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 1.29 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 1.46 ucm/s 10.1016/j.bmc.2016.07.019
None ADMET Papp 1.7 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 1.98 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 2.42 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 2.5 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 2.69 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 3.3 ucm/s 10.1016/j.bmc.2016.07.019
None ADMET Papp 3.7 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 4.7 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 5.85 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 8.3 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 8.4 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 11.13 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Papp 14.6 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 19.43 10^-6 cm/s 10.1016/j.ejmech.2022.114231
None ADMET Ratio -23.0 None 10.1124/dmd.110.034629
None ADMET Ratio -18.0 None 10.1124/dmd.110.034629
None ADMET Ratio 0.01 None 10.1021/acs.jmedchem.0c01826
None ADMET Ratio 0.76 None 10.1021/acs.jmedchem.0c01826
None ADMET Ratio 1.0 None 10.1021/acs.jmedchem.0c01826
None ADMET Ratio 1.0 None 10.1021/jm00019a012
None ADMET Ratio 1.0 None 10.1021/jm960505t
None ADMET Ratio 1.0 None 10.1124/dmd.110.034629
None ADMET Ratio 1.3 None 10.1124/dmd.110.034629
None ADMET Ratio 2.0 None 10.1021/acs.jmedchem.1c00404
None ADMET Ratio 2.27 None 10.1016/j.bmc.2016.07.019
None ADMET Ratio 2.4 None 10.1021/acs.jmedchem.1c00404
None ADMET Ratio 8.4 None 10.1124/dmd.110.034629
None ADMET Ratio 9.0 None 10.1124/dmd.110.034629
None ADMET Ratio 10.1 None 10.1124/dmd.110.034629
None ADMET Ratio 25.3 None 10.1124/dmd.110.034629
None ADMET Ratio 41.0 None 10.1124/dmd.110.034629
None ADMET Ratio 44.0 None 10.1124/dmd.110.034629
None ADMET Ratio 67.0 None 10.1124/dmd.110.034629
None ADMET Ratio 87.0 None 10.1124/dmd.110.034629
None ADMET Ratio 348.0 None 10.1124/dmd.110.034629
None ADMET Ratio 2000.0 None 10.1021/acs.jmedchem.1c00404
None ADMET Ratio CC50/IC50 20.0 None 10.1016/j.ejmech.2010.09.061
None ADMET Ratio IC50 0.18 None 10.1021/acs.jmedchem.2c00077
None ADMET Ratio IC50 2.45 None 10.1016/j.ejmech.2022.114439
None ADMET Ratio IC50 33.3 None 10.1016/j.ejmech.2021.113685
None ADMET Ratio IC50 872.0 None 10.1021/acsmedchemlett.1c00711
None ADMET Ratio IC50 38333.0 None 10.1021/np400567c
None ADMET Selectivity Index 0.2 None 10.1016/j.bmc.2021.116442
None ADMET Selectivity Index 0.26 None 10.1016/j.bmc.2021.116442
None ADMET Solubility 0.3 ug.mL-1 10.1021/jm00019a012
None ADMET Stability 47.57 % 10.1021/acs.jmedchem.1c00705
None ADMET T1/2 0.12 hr 10.1016/j.ejmech.2022.114231
None ADMET T1/2 0.12 hr 10.1021/acs.jmedchem.1c00246
None ADMET T1/2 1.21 hr 10.1021/acs.jmedchem.1c00246
None ADMET T1/2 1.35 hr 10.1016/j.ejmech.2022.114231
None ADMET T1/2 1.35 hr 10.1021/acs.jmedchem.1c00246
None ADMET T1/2 1.68 hr 10.1016/j.ejmech.2022.114231
None ADMET T1/2 6.8 hr 10.1021/acs.jmedchem.0c01826
None ADMET T1/2 7.7 hr 10.1021/acs.jmedchem.0c01826
None ADMET T1/2 8.0 hr 10.1021/acs.jmedchem.0c01826
None ADMET T1/2 11.0 hr 10.1124/dmd.108.020479
None ADMET TC50 4.39 uM 10.1016/j.bmc.2009.10.019
None ADMET TGI nan None 10.1016/j.ejmech.2010.11.013
None ADMET Tmax 0.08 hr 10.1021/acs.jmedchem.0c01826
None ADMET Tmax 0.44 hr 10.1016/j.ejmech.2022.114231
None ADMET Tmax 0.44 hr 10.1021/acs.jmedchem.1c00246
None ADMET Tmax 0.9 hr 10.1021/acs.jmedchem.0c01826
None ADMET Tmax 1.0 hr 10.1021/acs.jmedchem.0c01826
None ADMET Tmax 1.05 hr 10.1021/acs.jmedchem.6b01704
None ADMET Tmax 2.0 hr 10.1016/j.ejmech.2022.114231
None ADMET Tmax 2.0 hr 10.1021/acs.jmedchem.1c00246
None ADMET Tmax 2.51 hr 10.1016/j.ejmech.2022.114231
None ADMET Tmax 2.65 hr 10.1021/acs.jmedchem.1c00246
None ADMET Toxicity 0.0 None 10.1016/s0960-894x(02)00694-7
None ADMET Toxicity 2.0 None 10.1016/s0960-894x(02)00694-7
None ADMET Vd 23.6 l 10.1021/acs.jmedchem.0c01826
None ADMET Vd/F 5.06 l 10.1016/j.ejmech.2022.114231
None ADMET Vd/F 5.06 l 10.1021/acs.jmedchem.1c00246
None ADMET Vd/F 16.04 l 10.1016/j.ejmech.2022.114231
None ADMET Vd/F 19.06 l 10.1021/acs.jmedchem.1c00246
None ADMET Vd/F 67.38 l 10.1016/j.ejmech.2022.114231
None ADMET Vd/F 67.38 l 10.1021/acs.jmedchem.1c00246
None ADMET Vdss 2.4 L.kg-1 10.1021/jm0200409
None ADMET Vdss 2.4 L.kg-1 10.1021/jm030408h
None ADMET Vdss 3.0 L.kg-1 10.1124/dmd.108.020479
None Astrocyte ED50 0.01 ug ml-1 10.1021/np50022a019
None BC1 cell line IC50 103.61 nM 10.6019/CHEMBL1201861
None Erythrocyte Activity nan None 10.1021/acsmedchemlett.9b00339
None Erythrocyte HD50 nan None 10.1016/j.ejmech.2017.02.025
None Erythrocyte HD50 nan None 10.1021/acs.jnatprod.7b00578
None Erythrocyte IC50 nan None 10.1021/acs.jnatprod.8b00572
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 3.7 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 1.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 1.2 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 2.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 2.2 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 2.5 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 0.8 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None MDR ED50 0.2 ug ml-1 10.1016/j.bmcl.2007.06.083
None MDR IC50 400.0 nM 10.1021/jm0605031
None MDR IC50 nan None 10.1021/jm201121b
None Molecular identity unknown Activity 0.3 % 10.1021/jm0605031
None Molecular identity unknown Activity 0.3 % 10.1021/jm0708984
None Molecular identity unknown Activity 0.3 % 10.1021/jm801338r
None Molecular identity unknown Activity 1.03 % 10.1016/j.bmcl.2016.11.025
None Molecular identity unknown Activity 1.2 % 10.1021/jm0605031
None Molecular identity unknown Activity 1.2 % 10.1021/jm0708984
None Molecular identity unknown Activity 1.2 % 10.1021/jm801338r
None Molecular identity unknown Activity 8.5 % 10.1021/jm0605031
None Molecular identity unknown Activity 8.5 % 10.1021/jm0708984
None Molecular identity unknown Activity 8.5 % 10.1021/jm801338r
None Molecular identity unknown Activity 8.9 % 10.1021/jm0605031
None Molecular identity unknown Activity 8.9 % 10.1021/jm0708984
None Molecular identity unknown Activity 8.9 % 10.1021/jm801338r
None Molecular identity unknown Activity 9.4 % 10.1021/jm0605031
None Molecular identity unknown Activity 9.4 % 10.1021/jm0708984
None Molecular identity unknown Activity 9.4 % 10.1021/jm801338r
None Molecular identity unknown Activity 10.1 % 10.1021/jm0605031
None Molecular identity unknown Activity 10.1 % 10.1021/jm0708984
None Molecular identity unknown Activity 10.1 % 10.1021/jm801338r
None Molecular identity unknown Activity 11.0 % 10.1021/jm0605031
None Molecular identity unknown Activity 11.0 % 10.1021/jm0708984
None Molecular identity unknown Activity 11.0 % 10.1021/jm801338r
None Molecular identity unknown Activity 19.0 % 10.1021/jm0605031
None Molecular identity unknown Activity 19.0 % 10.1021/jm0708984
None Molecular identity unknown Activity 19.0 % 10.1021/jm801338r
None Molecular identity unknown Activity 26.6 % 10.1021/jm0605031
None Molecular identity unknown Activity 26.6 % 10.1021/jm0708984
None Molecular identity unknown Activity 26.6 % 10.1021/jm801338r
None Molecular identity unknown Activity 26.7 % 10.1021/jm0605031
None Molecular identity unknown Activity 26.7 % 10.1021/jm0708984
None Molecular identity unknown Activity 26.7 % 10.1021/jm801338r
None Molecular identity unknown Activity 27.0 % 10.1021/jm0605031
None Molecular identity unknown Activity 27.0 % 10.1021/jm0708984
None Molecular identity unknown Activity 27.0 % 10.1021/jm801338r
None Molecular identity unknown Activity 28.46 % 10.1016/j.bmcl.2016.11.025
None Molecular identity unknown Activity 31.1 % 10.1021/jm0605031
None Molecular identity unknown Activity 31.1 % 10.1021/jm0708984
None Molecular identity unknown Activity 31.1 % 10.1021/jm801338r
None Molecular identity unknown Activity 49.9 % 10.1021/jm0605031
None Molecular identity unknown Activity 49.9 % 10.1021/jm0708984
None Molecular identity unknown Activity 49.9 % 10.1021/jm801338r
None Molecular identity unknown Activity 63.2 % 10.1021/jm0605031
None Molecular identity unknown Activity 63.2 % 10.1021/jm0708984
None Molecular identity unknown Activity 63.2 % 10.1021/jm801338r
None Molecular identity unknown Activity 63.6 % 10.1021/jm0605031
None Molecular identity unknown Activity 63.6 % 10.1021/jm0708984
None Molecular identity unknown Activity 63.6 % 10.1021/jm801338r
None Molecular identity unknown Activity 64.8 % 10.1021/jm0605031
None Molecular identity unknown Activity 64.8 % 10.1021/jm0708984
None Molecular identity unknown Activity 64.8 % 10.1021/jm801338r
None Molecular identity unknown Activity 70.58 % 10.1016/j.bmcl.2016.11.025
None Molecular identity unknown Activity 87.8 % 10.1021/jm0605031
None Molecular identity unknown Activity 87.8 % 10.1021/jm0708984
None Molecular identity unknown Activity 87.9 % 10.1021/jm801338r
None Molecular identity unknown Activity 90.8 % 10.1021/jm0605031
None Molecular identity unknown Activity 90.8 % 10.1021/jm0708984
None Molecular identity unknown Activity 90.8 % 10.1021/jm801338r
None Molecular identity unknown Activity nan None 10.1016/j.bmc.2012.04.039
None Molecular identity unknown Activity nan None 10.1016/j.bmcl.2014.11.055
None Molecular identity unknown Activity nan None 10.1021/jm500561a
None Molecular identity unknown EC50 49.0 nM 10.1016/j.bmc.2011.06.010
None Molecular identity unknown EC50 49.0 nM 10.1016/j.ejmech.2010.04.032
None Molecular identity unknown EC50 49.0 nM 10.1021/jm0605031
None Molecular identity unknown EC50 49.0 nM 10.1021/jm0708984
None Molecular identity unknown EC50 49.0 nM 10.1021/jm801338r
None Molecular identity unknown Potency 1584.9 nM None
None NON-PROTEIN TARGET AbsAC35_uM 0.135 uM None
None NON-PROTEIN TARGET Activity 0.005 uM 10.1016/j.bmcl.2007.09.054
None NON-PROTEIN TARGET Activity 0.368 uM 10.1016/j.bmcl.2007.09.054
None NON-PROTEIN TARGET Activity 19.4 mm3 10.1039/C0MD00235F
None NON-PROTEIN TARGET Activity 35.0 % 10.1016/j.ejmech.2016.09.013
None NON-PROTEIN TARGET Activity 35.0 % None
None NON-PROTEIN TARGET Activity 40.0 % 10.1016/j.ejmech.2014.09.072
None NON-PROTEIN TARGET Activity 69.0 % 10.1021/jm500849z
None NON-PROTEIN TARGET Activity 76.0 % 10.1021/jm500849z
None NON-PROTEIN TARGET Activity 78.0 % 10.1021/ml1001568
None NON-PROTEIN TARGET Activity 85.0 None 10.1016/j.ejmech.2007.04.019
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmc.2010.02.012
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmc.2012.04.039
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2012.02.109
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2013.01.020
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2016.11.025
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2014.08.005
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2016.09.013
None NON-PROTEIN TARGET Activity nan None 10.1021/acs.jmedchem.5b00686
None NON-PROTEIN TARGET Activity nan None 10.1021/acs.jmedchem.5b01312
None NON-PROTEIN TARGET Activity nan None 10.1021/jm301058f
None NON-PROTEIN TARGET Activity nan None 10.1021/jm501518y
None NON-PROTEIN TARGET Activity nan None 10.1021/jm901763f
None NON-PROTEIN TARGET Assembly 100.0 % 10.1016/S0960-894X(01)80527-8
None NON-PROTEIN TARGET CC50 0.1 nM 10.1016/j.ejmech.2008.03.042
None NON-PROTEIN TARGET EC50 2.16 ug.mL-1 10.1016/j.bmcl.2008.06.099
None NON-PROTEIN TARGET EC50 2.16 ug.mL-1 10.1021/np800622a
None NON-PROTEIN TARGET EC50 2.8 nM None
None NON-PROTEIN TARGET EC50 4.8 nM None
None NON-PROTEIN TARGET EC50 10.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 13.0 nM 10.1021/jm500034j
None NON-PROTEIN TARGET EC50 16.2 nM None
None NON-PROTEIN TARGET EC50 18.0 nM 10.1021/jm500034j
None NON-PROTEIN TARGET EC50 490.0 nM 10.1016/j.bmc.2011.06.082
None NON-PROTEIN TARGET EC50 nan None 10.1038/nchembio873
None NON-PROTEIN TARGET ED50 1.0 uM 10.1021/np100406d
None NON-PROTEIN TARGET ED50 23.0 nM 10.1021/np0304417
None NON-PROTEIN TARGET ED50 100.0 nM 10.1016/j.bmc.2011.01.001
None NON-PROTEIN TARGET ED50 311.0 nM 10.1016/j.bmcl.2007.02.051
None NON-PROTEIN TARGET ED50 nan None 10.1021/np030241v
None NON-PROTEIN TARGET Fu 0.12 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI 58.0 % 10.1016/j.ejmech.2009.10.042
None NON-PROTEIN TARGET GI 58.5 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 59.0 % 10.1016/j.bmc.2011.09.060
None NON-PROTEIN TARGET GI 61.5 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 62.2 % 10.1016/j.bmcl.2012.02.109
None NON-PROTEIN TARGET GI 71.0 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 72.1 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 76.4 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 77.4 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 85.1 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 88.9 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI 89.4 % 10.1016/j.ejmech.2016.09.005
None NON-PROTEIN TARGET GI nan None 10.1016/j.bmcl.2013.11.032
None NON-PROTEIN TARGET GI nan None 10.1021/jm300117u
None NON-PROTEIN TARGET GI50 0.0024 nM 10.1021/jm0204136
None NON-PROTEIN TARGET GI50 0.0048 ug.mL-1 10.1016/j.bmcl.2016.11.056
None NON-PROTEIN TARGET GI50 0.01 nM 10.1016/j.bmcl.2009.04.020
None NON-PROTEIN TARGET GI50 0.026 ug.mL-1 10.1016/j.bmcl.2016.11.056
None NON-PROTEIN TARGET GI50 0.03 ug.mL-1 10.1021/np0602970
None NON-PROTEIN TARGET GI50 0.04 ug.mL-1 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET GI50 0.04 ug.mL-1 10.1021/np0602970
None NON-PROTEIN TARGET GI50 0.08 ug.mL-1 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET GI50 0.1374 ug.mL-1 10.1016/j.bmcl.2016.11.056
None NON-PROTEIN TARGET GI50 0.4 nM 10.1021/jm100846r
None NON-PROTEIN TARGET GI50 0.65 nM 10.1021/np970266s
None NON-PROTEIN TARGET GI50 1.792 nM 10.1016/j.bmcl.2013.12.083
None NON-PROTEIN TARGET GI50 2.392 nM 10.1016/j.bmcl.2013.12.083
None NON-PROTEIN TARGET GI50 2.409 nM 10.1016/j.bmcl.2013.12.083
None NON-PROTEIN TARGET GI50 3.088 nM 10.1016/j.bmcl.2013.12.083
None NON-PROTEIN TARGET GI50 3.605 nM 10.1016/j.bmcl.2013.12.083
None NON-PROTEIN TARGET GI50 3.889 nM 10.1016/j.bmcl.2013.12.083
None NON-PROTEIN TARGET GI50 4.0 nM 10.1016/j.ejmech.2016.05.004
None NON-PROTEIN TARGET GI50 4.0 nM 10.1021/jm400575x
None NON-PROTEIN TARGET GI50 4.7 nM 10.1021/np5002253
None NON-PROTEIN TARGET GI50 5.7 ug.mL-1 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET GI50 5.8 ug.mL-1 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET GI50 7.0 nM 10.1016/j.ejmech.2015.08.047
None NON-PROTEIN TARGET GI50 7.0 nM 10.1016/j.ejmech.2016.05.004
None NON-PROTEIN TARGET GI50 7.0 nM 10.1021/jm400711t
None NON-PROTEIN TARGET GI50 7.0 nM 10.1021/jm501518y
None NON-PROTEIN TARGET GI50 10.0 nM 10.1016/j.bmcl.2008.11.067
None NON-PROTEIN TARGET GI50 10.0 nM 10.1016/j.bmcl.2010.05.074
None NON-PROTEIN TARGET GI50 10.0 nM 10.1016/j.ejmech.2014.03.086
None NON-PROTEIN TARGET GI50 10.0 ug.mL-1 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET GI50 12.0 nM 10.1016/j.bmcl.2015.03.032
None NON-PROTEIN TARGET GI50 20.0 nM 10.1016/j.bmcl.2008.11.067
None NON-PROTEIN TARGET GI50 20.0 nM 10.1016/j.bmcl.2010.05.074
None NON-PROTEIN TARGET GI50 20.0 nM 10.1021/jm300705j
None NON-PROTEIN TARGET GI50 23.0 nM 10.1016/j.bmcl.2009.05.052
None NON-PROTEIN TARGET GI50 31.5 nM 10.1016/j.ejmech.2016.06.030
None NON-PROTEIN TARGET GI50 38.9 nM 10.1016/j.bmcl.2016.10.071
None NON-PROTEIN TARGET GI50 39.0 nM 10.1016/j.bmcl.2016.10.071
None NON-PROTEIN TARGET GI50 40.0 nM 10.1016/j.ejmech.2014.03.086
None NON-PROTEIN TARGET GI50 56.0 nM 10.1016/j.bmcl.2014.09.018
None NON-PROTEIN TARGET GI50 56.0 nM 10.1016/j.bmcl.2016.05.021
None NON-PROTEIN TARGET GI50 56.0 nM 10.1016/j.ejmech.2014.10.051
None NON-PROTEIN TARGET GI50 56.1 nM 10.1016/j.bmcl.2016.05.021
None NON-PROTEIN TARGET GI50 60.0 nM 10.1016/j.bmcl.2016.10.071
None NON-PROTEIN TARGET GI50 75.0 nM 10.1016/j.bmcl.2014.09.018
None NON-PROTEIN TARGET GI50 75.0 nM 10.1016/j.bmcl.2016.05.021
None NON-PROTEIN TARGET GI50 75.0 nM 10.1016/j.ejmech.2014.10.051
None NON-PROTEIN TARGET GI50 75.16 nM 10.1016/j.bmcl.2016.05.021
None NON-PROTEIN TARGET GI50 86.0 nM 10.1016/j.bmcl.2016.10.071
None NON-PROTEIN TARGET GI50 92.0 nM 10.1016/j.bmcl.2016.10.071
None NON-PROTEIN TARGET GI50 100.0 ug.mL-1 10.1016/j.ejmech.2016.09.059
None NON-PROTEIN TARGET GI50 160.0 nM 10.1016/j.bmcl.2009.04.020
None NON-PROTEIN TARGET GI50 200.0 nM 10.1016/j.ejmech.2014.03.086
None NON-PROTEIN TARGET GI50 600.0 nM 10.1021/np5002253
None NON-PROTEIN TARGET GI50 750.0 nM 10.1021/jm400575x
None NON-PROTEIN TARGET GI50 830.0 nM 10.1016/j.bmcl.2009.04.020
None NON-PROTEIN TARGET GI50 948.0 nM 10.1016/j.bmcl.2012.08.014
None NON-PROTEIN TARGET GI50 950.0 nM 10.1016/j.bmcl.2015.02.018
None NON-PROTEIN TARGET GI50 1000.0 nM 10.1016/j.bmc.2011.01.034
None NON-PROTEIN TARGET GI50 1000.0 nM 10.1016/j.ejmech.2011.12.025
None NON-PROTEIN TARGET GI50 1210.0 nM 10.1016/j.bmc.2015.07.016
None NON-PROTEIN TARGET GI50 1210.0 nM 10.1016/j.ejmech.2013.06.041
None NON-PROTEIN TARGET GI50 1210.0 nM 10.1021/jm4016526
None NON-PROTEIN TARGET GI50 1800.0 nM 10.1016/j.bmc.2013.11.018
None NON-PROTEIN TARGET GI50 1803.0 nM 10.1016/j.bmc.2012.11.047
None NON-PROTEIN TARGET GI50 2000.0 nM 10.1021/jm400575x
None NON-PROTEIN TARGET GI50 2400.0 nM 10.1016/j.ejmech.2016.05.004
None NON-PROTEIN TARGET GI50 2600.0 nM 10.1016/j.bmc.2016.05.025
None NON-PROTEIN TARGET GI50 7540.0 nM 10.1016/j.bmcl.2009.07.127
None NON-PROTEIN TARGET GI50 9800.0 nM 10.1021/jm400711t
None NON-PROTEIN TARGET GI50 9800.0 nM 10.1021/jm501518y
None NON-PROTEIN TARGET GI50 10000.0 nM 10.1016/j.ejmech.2015.08.047
None NON-PROTEIN TARGET GI50 10000.0 nM 10.1016/j.ejmech.2016.05.004
None NON-PROTEIN TARGET GI50 16170.0 nM 10.1021/jm100846r
None NON-PROTEIN TARGET GI50 nan None 10.1016/j.bmc.2016.05.025
None NON-PROTEIN TARGET GI50 nan None 10.1016/j.ejmech.2016.05.004
None NON-PROTEIN TARGET GI50 nan None 10.1021/jm501518y
None NON-PROTEIN TARGET GI90 0.075 ug ml-1 10.1016/j.bmcl.2016.11.056
None NON-PROTEIN TARGET GI90 5.21 ug ml-1 10.1016/j.bmcl.2016.11.056
None NON-PROTEIN TARGET GI90 5.814 ug ml-1 10.1016/j.bmcl.2016.11.056
None NON-PROTEIN TARGET Hepatotoxicity (acute) 6.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 7.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 50.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC30 49.0 uM 10.1021/np200241c
None NON-PROTEIN TARGET IC50 0.001 ug.mL-1 10.1021/np0202273
None NON-PROTEIN TARGET IC50 0.0011 ug.mL-1 10.1016/j.bmcl.2012.04.084
None NON-PROTEIN TARGET IC50 0.002 ug.mL-1 10.1016/s0960-894x(98)00005-5
None NON-PROTEIN TARGET IC50 0.003 ug.mL-1 10.1016/j.bmc.2007.03.041
None NON-PROTEIN TARGET IC50 0.008 ug.mL-1 10.1021/np060101w
None NON-PROTEIN TARGET IC50 0.0088 ug.mL-1 10.1016/s0960-894x(98)00262-5
None NON-PROTEIN TARGET IC50 0.01 ug.mL-1 10.1016/j.bmc.2007.03.041
None NON-PROTEIN TARGET IC50 0.016 nM 10.1021/np200431k
None NON-PROTEIN TARGET IC50 0.016 nM 10.1021/np5009569
None NON-PROTEIN TARGET IC50 0.02 ug.mL-1 10.1021/np50078a018
None NON-PROTEIN TARGET IC50 0.026 ug.mL-1 10.1016/j.ejmech.2014.10.013
None NON-PROTEIN TARGET IC50 0.08 ug.mL-1 10.1021/np050082a
None NON-PROTEIN TARGET IC50 0.1 ug.mL-1 10.1021/np010071r
None NON-PROTEIN TARGET IC50 0.2 nM 10.1021/acs.jnatprod.6b00299
None NON-PROTEIN TARGET IC50 0.2 ug.mL-1 10.1016/j.bmcl.2015.08.057
None NON-PROTEIN TARGET IC50 0.3 nM 10.1016/j.bmcl.2006.11.008
None NON-PROTEIN TARGET IC50 0.3 nM 10.1016/j.bmcl.2015.03.081
None NON-PROTEIN TARGET IC50 0.38 ug.mL-1 10.1016/j.ejmech.2014.03.021
None NON-PROTEIN TARGET IC50 0.5 nM 10.1016/j.bmcl.2006.11.008
None NON-PROTEIN TARGET IC50 0.6 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 0.75 ug.mL-1 10.1021/np9005579
None NON-PROTEIN TARGET IC50 0.9 nM 10.1016/S0960-894X(97)10152-4
None NON-PROTEIN TARGET IC50 0.9 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 1.0 nM 10.1016/j.bmcl.2008.06.039
None NON-PROTEIN TARGET IC50 1.0 nM 10.1016/j.ejmech.2013.03.029
None NON-PROTEIN TARGET IC50 1.0 nM 10.1016/j.ejmech.2014.09.072
None NON-PROTEIN TARGET IC50 1.0 nM 10.1016/j.ejmech.2015.09.019
None NON-PROTEIN TARGET IC50 1.0 nM 10.1021/jm900476c
None NON-PROTEIN TARGET IC50 1.09 nM 10.1016/j.bmcl.2009.12.041
None NON-PROTEIN TARGET IC50 1.1 nM 10.1021/np5009569
None NON-PROTEIN TARGET IC50 1.1 nM 10.1038/nchembio853
None NON-PROTEIN TARGET IC50 1.145 ug.mL-1 10.1016/j.bmcl.2011.12.024
None NON-PROTEIN TARGET IC50 1.2 nM 10.1021/jm901763f
None NON-PROTEIN TARGET IC50 1.6 nM 10.1021/acs.jmedchem.5b00085
None NON-PROTEIN TARGET IC50 1.6 nM 10.1021/jm061348t
None NON-PROTEIN TARGET IC50 1.66 nM 10.1021/acs.jnatprod.5b00650
None NON-PROTEIN TARGET IC50 1.7 nM 10.1016/j.bmc.2015.02.004
None NON-PROTEIN TARGET IC50 1.8 nM 10.1016/j.bmcl.2015.03.017
None NON-PROTEIN TARGET IC50 1.95 10'-8mg/ml 10.1016/j.bmcl.2016.02.055
None NON-PROTEIN TARGET IC50 1.99 nM 10.1021/acs.jnatprod.5b00650
None NON-PROTEIN TARGET IC50 2.0 nM 10.1016/j.bmc.2008.02.029
None NON-PROTEIN TARGET IC50 2.0 nM 10.1021/acs.jnatprod.5b00988
None NON-PROTEIN TARGET IC50 2.0 nM 10.1021/acs.jnatprod.5b00989
None NON-PROTEIN TARGET IC50 2.0 nM None
None NON-PROTEIN TARGET IC50 2.0 ug.mL-1 10.1021/np800167x
None NON-PROTEIN TARGET IC50 2.3 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 2.3 nM 10.1021/acs.jnatprod.5b00650
None NON-PROTEIN TARGET IC50 2.45 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 2.5 nM 10.1016/j.bmcl.2015.03.017
None NON-PROTEIN TARGET IC50 2.5 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 2.56 10'-8mg/ml 10.1016/j.bmcl.2016.02.055
None NON-PROTEIN TARGET IC50 2.6 nM 10.1016/j.ejmech.2014.06.016
None NON-PROTEIN TARGET IC50 2.6 nM None
None NON-PROTEIN TARGET IC50 2.7 nM 10.1016/j.bmcl.2014.11.055
None NON-PROTEIN TARGET IC50 2.8 nM 10.1016/j.bmc.2011.05.030
None NON-PROTEIN TARGET IC50 2.8 nM 10.1016/j.bmcl.2014.03.011
None NON-PROTEIN TARGET IC50 2.8 nM 10.1016/j.ejmech.2015.09.019
None NON-PROTEIN TARGET IC50 2.8 nM 10.1021/jm070194u
None NON-PROTEIN TARGET IC50 2.96 nM 10.1016/j.bmcl.2011.01.096
None NON-PROTEIN TARGET IC50 2.96 nM 10.1016/j.bmcl.2011.01.097
None NON-PROTEIN TARGET IC50 2.96 nM 10.1016/j.bmcl.2011.01.111
None NON-PROTEIN TARGET IC50 3.0 nM 10.1016/j.bmc.2010.07.069
None NON-PROTEIN TARGET IC50 3.0 nM 10.1016/j.bmcl.2012.10.077
None NON-PROTEIN TARGET IC50 3.0 nM 10.1021/jm500024v
None NON-PROTEIN TARGET IC50 3.1 nM 10.1021/jm800086e
None NON-PROTEIN TARGET IC50 3.3 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 3.4 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 3.8 nM 10.1021/acs.jnatprod.5b00908
None NON-PROTEIN TARGET IC50 4.0 nM 10.1016/j.bmc.2009.07.051
None NON-PROTEIN TARGET IC50 4.0 nM 10.1016/j.ejmech.2014.10.075
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm100884b
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm200570p
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm300176j
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm3013097
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 4.0 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 4.1 nM 10.1016/j.ejmech.2014.05.009
None NON-PROTEIN TARGET IC50 4.2 nM 10.1016/j.bmc.2014.05.048
None NON-PROTEIN TARGET IC50 4.2 nM 10.1021/np200431k
None NON-PROTEIN TARGET IC50 4.2 nM 10.1021/np5009569
None NON-PROTEIN TARGET IC50 4.4 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 4.9 nM 10.1016/j.bmc.2015.02.004
None NON-PROTEIN TARGET IC50 5.0 nM 10.1016/j.bmcl.2008.02.029
None NON-PROTEIN TARGET IC50 5.0 nM 10.1016/j.bmcl.2013.07.032
None NON-PROTEIN TARGET IC50 5.0 nM 10.1016/j.ejmech.2014.10.037
None NON-PROTEIN TARGET IC50 5.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 5.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 5.1 nM 10.1016/j.bmcl.2015.03.017
None NON-PROTEIN TARGET IC50 5.1 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 5.2 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 5.3 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 5.4 nM 10.1016/j.bmcl.2006.11.008
None NON-PROTEIN TARGET IC50 6.0 nM 10.1016/j.bmc.2011.06.010
None NON-PROTEIN TARGET IC50 6.0 nM 10.1016/j.bmcl.2015.01.056
None NON-PROTEIN TARGET IC50 6.0 nM 10.1016/j.ejmech.2010.04.032
None NON-PROTEIN TARGET IC50 6.0 nM 10.1016/j.ejmech.2015.11.009
None NON-PROTEIN TARGET IC50 6.0 nM 10.1021/acs.jnatprod.6b00305
None NON-PROTEIN TARGET IC50 6.0 nM 10.1021/jm0605031
None NON-PROTEIN TARGET IC50 6.0 nM 10.1021/jm0708984
None NON-PROTEIN TARGET IC50 6.0 nM 10.1021/jm200436t
None NON-PROTEIN TARGET IC50 6.0 nM 10.1021/jm8006257
None NON-PROTEIN TARGET IC50 6.08 nM 10.1021/np500342m
None NON-PROTEIN TARGET IC50 6.1 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 6.3 nM 10.1016/j.bmc.2015.03.061
None NON-PROTEIN TARGET IC50 6.4 nM 10.1021/acs.jnatprod.6b00299
None NON-PROTEIN TARGET IC50 6.4 nM 10.1021/np200431k
None NON-PROTEIN TARGET IC50 6.4 nM 10.1021/np5009569
None NON-PROTEIN TARGET IC50 7.0 nM 10.1016/j.bmc.2007.03.086
None NON-PROTEIN TARGET IC50 7.0 nM 10.1016/j.ejmech.2014.10.037
None NON-PROTEIN TARGET IC50 7.0 nM 10.1021/np050424c
None NON-PROTEIN TARGET IC50 7.3 ug.mL-1 10.1016/j.ejmech.2014.10.013
None NON-PROTEIN TARGET IC50 7.9 nM 10.1016/j.bmc.2014.06.042
None NON-PROTEIN TARGET IC50 7.9 nM 10.1021/jm201031f
None NON-PROTEIN TARGET IC50 7.9 nM 10.1021/jm4011115
None NON-PROTEIN TARGET IC50 7.9 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 8.0 nM 10.1016/j.ejmech.2014.10.037
None NON-PROTEIN TARGET IC50 8.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 8.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 8.0 nM 10.1021/jm8006257
None NON-PROTEIN TARGET IC50 8.0 nM 10.1021/np5005196
None NON-PROTEIN TARGET IC50 8.1 nM 10.1016/j.bmc.2013.03.078
None NON-PROTEIN TARGET IC50 8.4 nM 10.1016/j.bmc.2015.06.043
None NON-PROTEIN TARGET IC50 8.4 nM 10.1016/j.bmc.2015.08.038
None NON-PROTEIN TARGET IC50 8.4 nM 10.1016/j.ejmech.2014.02.061
None NON-PROTEIN TARGET IC50 8.9 nM 10.1021/jm040056u
None NON-PROTEIN TARGET IC50 9.0 nM 10.1016/j.bmcl.2014.07.035
None NON-PROTEIN TARGET IC50 10.0 nM 10.1016/j.bmc.2010.11.054
None NON-PROTEIN TARGET IC50 10.0 nM 10.1016/j.bmc.2011.06.010
None NON-PROTEIN TARGET IC50 10.0 nM 10.1016/j.ejmech.2009.07.027
None NON-PROTEIN TARGET IC50 10.0 nM 10.1016/j.ejmech.2010.04.032
None NON-PROTEIN TARGET IC50 10.0 nM 10.1021/jm0605031
None NON-PROTEIN TARGET IC50 10.0 nM 10.1021/jm0708984
None NON-PROTEIN TARGET IC50 10.0 nM 10.1021/ml4004793
None NON-PROTEIN TARGET IC50 11.0 nM 10.1016/j.bmcl.2016.12.007
None NON-PROTEIN TARGET IC50 11.0 nM 10.1021/np400851k
None NON-PROTEIN TARGET IC50 11.3 nM 10.1021/jm301864s
None NON-PROTEIN TARGET IC50 12.0 nM 10.1016/j.ejmech.2014.11.068
None NON-PROTEIN TARGET IC50 12.0 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 12.3 nM 10.1021/np900302w
None NON-PROTEIN TARGET IC50 13.5 nM 10.1021/acsmedchemlett.5b00418
None NON-PROTEIN TARGET IC50 13.8 nM 10.1016/j.bmc.2015.02.057
None NON-PROTEIN TARGET IC50 16.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 17.0 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 18.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 18.0 nM 10.1021/np400297p
None NON-PROTEIN TARGET IC50 19.0 nM 10.1021/acs.jmedchem.6b00021
None NON-PROTEIN TARGET IC50 19.0 nM 10.1038/nchembio853
None NON-PROTEIN TARGET IC50 20.0 nM 10.1016/j.ejmech.2013.01.007
None NON-PROTEIN TARGET IC50 20.0 nM 10.1021/acs.jnatprod.5b00908
None NON-PROTEIN TARGET IC50 20.0 nM 10.1021/acs.jnatprod.6b00137
None NON-PROTEIN TARGET IC50 20.0 nM 10.1021/acs.jnatprod.6b00305
None NON-PROTEIN TARGET IC50 20.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 20.0 nM 10.1021/np010322w
None NON-PROTEIN TARGET IC50 20.0 nM 10.1021/np400851k
None NON-PROTEIN TARGET IC50 21.0 nM 10.1021/jm500024v
None NON-PROTEIN TARGET IC50 22.0 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 23.0 nM 10.1021/acs.jmedchem.6b00021
None NON-PROTEIN TARGET IC50 23.0 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 24.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 26.0 nM 10.1016/j.bmc.2008.11.016
None NON-PROTEIN TARGET IC50 26.0 nM 10.1016/j.bmcl.2007.03.070
None NON-PROTEIN TARGET IC50 26.0 nM 10.1021/jm060717i
None NON-PROTEIN TARGET IC50 26.0 nM 10.1021/np400851k
None NON-PROTEIN TARGET IC50 27.0 nM 10.1021/np800716f
None NON-PROTEIN TARGET IC50 28.0 nM 10.1016/j.ejmech.2011.08.034
None NON-PROTEIN TARGET IC50 28.0 nM 10.1021/jm200488a
None NON-PROTEIN TARGET IC50 30.0 nM 10.1021/acs.jnatprod.6b00137
None NON-PROTEIN TARGET IC50 30.0 nM 10.1021/acs.jnatprod.6b00305
None NON-PROTEIN TARGET IC50 30.0 nM 10.1021/jm801338r
None NON-PROTEIN TARGET IC50 30.0 nM 10.1038/nchembio853
None NON-PROTEIN TARGET IC50 31.0 nM 10.1021/np0303658
None NON-PROTEIN TARGET IC50 32.8 nM 10.1016/j.bmc.2014.05.048
None NON-PROTEIN TARGET IC50 35.0 nM 10.1016/j.ejmech.2011.08.034
None NON-PROTEIN TARGET IC50 35.0 nM 10.1021/jm200488a
None NON-PROTEIN TARGET IC50 36.0 nM 10.1016/j.bmcl.2016.12.007
None NON-PROTEIN TARGET IC50 38.0 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 40.0 nM 10.1016/j.bmcl.2011.11.016
None NON-PROTEIN TARGET IC50 50.0 nM 10.1021/jm801338r
None NON-PROTEIN TARGET IC50 55.7 nM 10.1016/j.bmc.2015.02.057
None NON-PROTEIN TARGET IC50 60.0 nM 10.1021/acs.jnatprod.6b00137
None NON-PROTEIN TARGET IC50 60.0 nM 10.1021/acs.jnatprod.6b00305
None NON-PROTEIN TARGET IC50 60.0 nM 10.1021/jm070534b
None NON-PROTEIN TARGET IC50 66.0 nM 10.1016/j.bmcl.2015.01.056
None NON-PROTEIN TARGET IC50 67.27 nM 10.1016/j.ejmech.2016.03.029
None NON-PROTEIN TARGET IC50 68.0 nM 10.1021/acs.jnatprod.6b00327
None NON-PROTEIN TARGET IC50 75.0 nM 10.1016/j.ejmech.2011.10.013
None NON-PROTEIN TARGET IC50 75.2 nM 10.1016/j.bmc.2012.10.001
None NON-PROTEIN TARGET IC50 75.2 nM 10.1021/jm200392p
None NON-PROTEIN TARGET IC50 80.0 nM 10.1021/acs.jnatprod.6b00137
None NON-PROTEIN TARGET IC50 80.0 nM 10.1021/jm070534b
None NON-PROTEIN TARGET IC50 81.4 nM 10.1016/j.bmc.2014.05.048
None NON-PROTEIN TARGET IC50 92.0 nM 10.1021/jm040056u
None NON-PROTEIN TARGET IC50 92.3 nM 10.1021/jm400043d
None NON-PROTEIN TARGET IC50 100.0 nM 10.1016/j.bmcl.2016.11.025
None NON-PROTEIN TARGET IC50 100.0 nM 10.1016/j.ejmech.2013.01.007
None NON-PROTEIN TARGET IC50 100.0 nM 10.1039/C4MD00344F
None NON-PROTEIN TARGET IC50 100.0 nM None
None NON-PROTEIN TARGET IC50 102.0 nM 10.1021/jm070534b
None NON-PROTEIN TARGET IC50 107.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 110.0 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 120.0 nM 10.1016/j.bmc.2015.02.004
None NON-PROTEIN TARGET IC50 125.0 nM 10.1021/acs.jmedchem.6b00021
None NON-PROTEIN TARGET IC50 130.0 nM 10.1021/np0704957
None NON-PROTEIN TARGET IC50 135.0 nM 10.1016/j.bmc.2015.06.043
None NON-PROTEIN TARGET IC50 135.0 nM 10.1016/j.ejmech.2014.02.061
None NON-PROTEIN TARGET IC50 135.0 nM 10.1021/acs.jmedchem.6b00021
None NON-PROTEIN TARGET IC50 140.0 nM 10.1016/j.bmcl.2004.06.080
None NON-PROTEIN TARGET IC50 140.0 nM 10.1021/np200431k
None NON-PROTEIN TARGET IC50 140.0 nM 10.1021/np5009569
None NON-PROTEIN TARGET IC50 144.6 nM 10.1021/acs.jmedchem.5b00085
None NON-PROTEIN TARGET IC50 149.3 nM 10.1016/j.ejmech.2014.06.016
None NON-PROTEIN TARGET IC50 150.0 nM 10.1016/j.bmc.2012.12.029
None NON-PROTEIN TARGET IC50 160.7 nM 10.1016/j.bmc.2014.02.036
None NON-PROTEIN TARGET IC50 160.7 nM 10.1021/jm800086e
None NON-PROTEIN TARGET IC50 160.7 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 180.0 nM 10.1039/C4MD00573B
None NON-PROTEIN TARGET IC50 183.0 nM 10.1016/j.bmcl.2007.04.030
None NON-PROTEIN TARGET IC50 188.0 nM 10.1021/jm300564b
None NON-PROTEIN TARGET IC50 200.0 nM 10.1016/s0960-894x(02)00784-9
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/acs.jnatprod.6b00137
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/np400070x
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/np400379u
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/np4004068
None NON-PROTEIN TARGET IC50 210.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 240.0 nM 10.1021/jm501599u
None NON-PROTEIN TARGET IC50 266.0 nM 10.1021/jm500849z
None NON-PROTEIN TARGET IC50 273.0 nM 10.1016/j.bmc.2014.06.042
None NON-PROTEIN TARGET IC50 273.0 nM 10.1021/jm201031f
None NON-PROTEIN TARGET IC50 273.0 nM 10.1021/jm4011115
None NON-PROTEIN TARGET IC50 277.0 nM 10.1021/jm4001117
None NON-PROTEIN TARGET IC50 299.0 nM 10.1016/j.bmc.2014.05.048
None NON-PROTEIN TARGET IC50 300.0 nM 10.1021/jm800086e
None NON-PROTEIN TARGET IC50 300.0 nM 10.1021/jm801338r
None NON-PROTEIN TARGET IC50 300.0 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 346.0 nM 10.1021/jm800086e
None NON-PROTEIN TARGET IC50 350.0 nM 10.1016/j.ejmech.2014.05.084
None NON-PROTEIN TARGET IC50 379.0 nM 10.1016/j.bmc.2010.07.069
None NON-PROTEIN TARGET IC50 400.0 nM 10.1016/j.bmc.2011.06.010
None NON-PROTEIN TARGET IC50 400.0 nM 10.1016/j.ejmech.2010.04.032
None NON-PROTEIN TARGET IC50 400.0 nM 10.1021/jm0708984
None NON-PROTEIN TARGET IC50 410.0 nM 10.1016/j.bmc.2010.07.069
None NON-PROTEIN TARGET IC50 415.0 nM 10.1021/jm901249g
None NON-PROTEIN TARGET IC50 430.0 nM 10.1016/j.ejmech.2012.03.024
None NON-PROTEIN TARGET IC50 430.0 nM 10.1016/j.ejmech.2012.11.002
None NON-PROTEIN TARGET IC50 430.0 nM 10.1016/j.ejmech.2013.04.012
None NON-PROTEIN TARGET IC50 500.0 nM 10.1016/j.bmcl.2013.07.032
None NON-PROTEIN TARGET IC50 532.95 nM 10.1016/j.bmc.2014.02.036
None NON-PROTEIN TARGET IC50 532.95 nM 10.1021/jm800086e
None NON-PROTEIN TARGET IC50 532.95 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 535.0 nM 10.1016/j.bmcl.2006.09.068
None NON-PROTEIN TARGET IC50 630.0 nM 10.1016/j.bmcl.2016.12.007
None NON-PROTEIN TARGET IC50 750.0 nM 10.1021/jm200570p
None NON-PROTEIN TARGET IC50 750.0 nM 10.1021/jm300176j
None NON-PROTEIN TARGET IC50 750.0 nM 10.1039/C4MD00573B
None NON-PROTEIN TARGET IC50 820.0 nM 10.1016/j.bmcl.2011.11.016
None NON-PROTEIN TARGET IC50 850.0 nM 10.1021/np5004559
None NON-PROTEIN TARGET IC50 900.0 nM 10.1038/nchembio853
None NON-PROTEIN TARGET IC50 920.0 nM 10.1016/j.bmcl.2007.03.026
None NON-PROTEIN TARGET IC50 930.0 nM 10.1021/np070208z
None NON-PROTEIN TARGET IC50 940.0 nM 10.1016/j.bmcl.2016.12.007
None NON-PROTEIN TARGET IC50 940.0 nM 10.1021/np5004559
None NON-PROTEIN TARGET IC50 949.0 nM 10.1016/j.ejmech.2011.02.011
None NON-PROTEIN TARGET IC50 970.0 nM 10.1016/j.ejmech.2014.06.010
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2011.01.096
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2011.01.097
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2011.01.111
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2012.10.077
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/jm061348t
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/jm301151t
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/np070547s
None NON-PROTEIN TARGET IC50 1050.0 nM 10.1016/j.ejmech.2013.01.007
None NON-PROTEIN TARGET IC50 1100.0 nM 10.1016/j.bmcl.2013.07.032
None NON-PROTEIN TARGET IC50 1180.0 nM 10.1016/j.bmcl.2014.10.088
None NON-PROTEIN TARGET IC50 1187.2 nM 10.1016/j.bmc.2015.03.061
None NON-PROTEIN TARGET IC50 1239.0 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 1244.0 nM 10.1016/j.bmc.2014.05.048
None NON-PROTEIN TARGET IC50 1300.0 nM 10.1016/j.bmc.2008.10.084
None NON-PROTEIN TARGET IC50 1330.0 nM 10.1016/j.bmcl.2014.10.088
None NON-PROTEIN TARGET IC50 1400.0 nM 10.1021/np070458f
None NON-PROTEIN TARGET IC50 1430.0 nM 10.1016/j.bmcl.2014.10.088
None NON-PROTEIN TARGET IC50 1440.0 nM 10.1016/j.bmc.2008.02.012
None NON-PROTEIN TARGET IC50 1440.0 nM 10.1016/j.bmcl.2014.06.060
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1016/j.bmcl.2010.05.034
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1016/j.ejmech.2009.12.060
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1021/jm2012886
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1021/np500583z
None NON-PROTEIN TARGET IC50 1580.0 nM 10.1016/j.bmcl.2014.08.063
None NON-PROTEIN TARGET IC50 1600.0 nM 10.1016/j.ejmech.2013.12.059
None NON-PROTEIN TARGET IC50 1620.0 nM 10.1016/j.bmcl.2004.06.080
None NON-PROTEIN TARGET IC50 1764.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 1764.0 nM 10.1021/jm3013097
None NON-PROTEIN TARGET IC50 1764.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 1900.0 nM 10.1016/j.bmcl.2011.06.034
None NON-PROTEIN TARGET IC50 2013.0 nM 10.1016/j.bmc.2008.11.016
None NON-PROTEIN TARGET IC50 2013.0 nM 10.1016/j.bmcl.2007.03.070
None NON-PROTEIN TARGET IC50 2013.0 nM 10.1021/jm060717i
None NON-PROTEIN TARGET IC50 2300.0 nM 10.1021/np010322w
None NON-PROTEIN TARGET IC50 2500.0 nM 10.1021/np400742p
None NON-PROTEIN TARGET IC50 2600.0 nM 10.1016/j.bmcl.2015.09.010
None NON-PROTEIN TARGET IC50 2600.0 nM 10.1021/jm500024v
None NON-PROTEIN TARGET IC50 2700.0 nM 10.1016/j.bmc.2011.05.030
None NON-PROTEIN TARGET IC50 2700.0 nM 10.1021/jm070194u
None NON-PROTEIN TARGET IC50 2730.0 nM 10.1016/j.bmcl.2008.07.101
None NON-PROTEIN TARGET IC50 2900.0 nM 10.1016/j.ejmech.2013.12.059
None NON-PROTEIN TARGET IC50 3000.0 nM 10.1016/j.bmc.2011.06.010
None NON-PROTEIN TARGET IC50 3340.0 nM 10.1016/j.bmc.2009.03.037
None NON-PROTEIN TARGET IC50 3340.0 nM 10.1016/j.bmc.2010.10.047
None NON-PROTEIN TARGET IC50 3340.0 nM 10.1016/j.ejmech.2011.01.057
None NON-PROTEIN TARGET IC50 3340.0 nM 10.1016/j.ejmech.2011.08.034
None NON-PROTEIN TARGET IC50 3340.0 nM 10.1021/jm200488a
None NON-PROTEIN TARGET IC50 3990.0 nM 10.1021/jm500561a
None NON-PROTEIN TARGET IC50 4287.0 nM 10.1016/j.ejmech.2015.09.019
None NON-PROTEIN TARGET IC50 4400.0 nM 10.1016/j.bmcl.2015.01.056
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.bmcl.2008.02.029
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.bmcl.2013.07.032
None NON-PROTEIN TARGET IC50 5100.0 nM 10.1016/j.ejmech.2014.10.037
None NON-PROTEIN TARGET IC50 5300.0 nM 10.1016/j.ejmech.2013.01.007
None NON-PROTEIN TARGET IC50 5680.0 nM 10.1021/acs.jmedchem.6b00021
None NON-PROTEIN TARGET IC50 6000.0 nM 10.1021/acs.jmedchem.5b00310
None NON-PROTEIN TARGET IC50 6200.0 nM 10.1016/j.bmcl.2015.01.056
None NON-PROTEIN TARGET IC50 6400.0 nM 10.1021/ml1003074
None NON-PROTEIN TARGET IC50 6900.0 nM 10.1016/j.ejmech.2013.01.007
None NON-PROTEIN TARGET IC50 7260.0 nM 10.1021/jm8006257
None NON-PROTEIN TARGET IC50 7538.0 nM 10.1016/j.bmcl.2009.07.127
None NON-PROTEIN TARGET IC50 8000.0 nM 10.1016/j.bmc.2008.02.029
None NON-PROTEIN TARGET IC50 8100.0 nM 10.1021/np040072u
None NON-PROTEIN TARGET IC50 8100.0 nM 10.1021/np0680073
None NON-PROTEIN TARGET IC50 8100.0 nM 10.1021/np068015j
None NON-PROTEIN TARGET IC50 8100.0 nM 10.1021/np3003639
None NON-PROTEIN TARGET IC50 9260.0 nM 10.1016/j.ejmech.2012.07.047
None NON-PROTEIN TARGET IC50 9260.0 nM 10.1016/j.ejmech.2012.07.051
None NON-PROTEIN TARGET IC50 9800.0 nM 10.1016/j.bmcl.2015.08.034
None NON-PROTEIN TARGET IC50 10000.0 nM 10.1016/j.bmcl.2013.07.032
None NON-PROTEIN TARGET IC50 10000.0 nM 10.1016/j.bmcl.2015.01.056
None NON-PROTEIN TARGET IC50 10000.0 nM 10.1039/C4MD00573B
None NON-PROTEIN TARGET IC50 10027.0 nM 10.1016/j.bmcl.2009.04.070
None NON-PROTEIN TARGET IC50 10027.0 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 12950.0 nM 10.1016/j.bmcl.2016.11.025
None NON-PROTEIN TARGET IC50 13000.0 nM 10.1021/jm100659v
None NON-PROTEIN TARGET IC50 14800.0 nM 10.1016/j.bmc.2015.06.043
None NON-PROTEIN TARGET IC50 14800.0 nM 10.1016/j.ejmech.2014.02.061
None NON-PROTEIN TARGET IC50 15600.0 nM 10.1021/acsmedchemlett.6b00466
None NON-PROTEIN TARGET IC50 16500.0 nM 10.1016/j.bmc.2014.06.042
None NON-PROTEIN TARGET IC50 16500.0 nM 10.1021/jm201031f
None NON-PROTEIN TARGET IC50 16500.0 nM 10.1021/jm4011115
None NON-PROTEIN TARGET IC50 17800.0 nM 10.1016/j.bmcl.2009.04.070
None NON-PROTEIN TARGET IC50 17800.0 nM 10.1021/np8006556
None NON-PROTEIN TARGET IC50 24000.0 nM 10.1016/j.ejmech.2013.01.007
None NON-PROTEIN TARGET IC50 25000.0 nM 10.1016/j.bmcl.2014.03.011
None NON-PROTEIN TARGET IC50 50000.0 nM 10.1016/j.bmc.2011.02.052
None NON-PROTEIN TARGET IC50 90000.0 nM 10.1021/np200241c
None NON-PROTEIN TARGET IC50 100000.0 nM 10.1016/j.bmcl.2016.11.025
None NON-PROTEIN TARGET IC50 1000000.0 nM 10.1016/j.bmcl.2012.09.104
None NON-PROTEIN TARGET IC50 1484400.0 nM 10.1016/j.bmcl.2011.06.036
None NON-PROTEIN TARGET IC50 43600000.0 nM 10.1021/acs.jmedchem.5b00058
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.01.061
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2010.11.030
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmcl.2014.08.010
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmcl.2015.04.051
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2011.10.013
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2015.02.031
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm200392p
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm201121b
None NON-PROTEIN TARGET IC50 nan None None
None NON-PROTEIN TARGET Inhibition 0.0 % 10.1021/np010322w
None NON-PROTEIN TARGET Inhibition 13.1 % 10.1021/np010322w
None NON-PROTEIN TARGET Inhibition 26.0 % 10.1016/j.bmcl.2007.10.011
None NON-PROTEIN TARGET Inhibition 40.0 % 10.1016/j.ejmech.2015.09.019
None NON-PROTEIN TARGET Inhibition 45.0 % 10.1016/j.ejmech.2014.06.010
None NON-PROTEIN TARGET Inhibition 50.0 % 10.1016/j.ejmech.2016.05.004
None NON-PROTEIN TARGET Inhibition 76.0 % 10.1021/jm301058f
None NON-PROTEIN TARGET LC50 8.2 nM 10.1021/acs.jnatprod.6b00290
None NON-PROTEIN TARGET LC50 9.8 nM 10.1021/acs.jnatprod.6b00290
None NON-PROTEIN TARGET LC50 18.0 nM 10.1021/acs.jnatprod.6b00290
None NON-PROTEIN TARGET LC50 31.25 nM 10.1021/acs.jnatprod.6b00290
None NON-PROTEIN TARGET LC50 62.5 nM 10.1021/acs.jnatprod.6b00290
None NON-PROTEIN TARGET LC50 620.0 nM 10.1021/np970266s
None NON-PROTEIN TARGET LCK 0.7 None 10.1021/jm301058f
None NON-PROTEIN TARGET LCK 4.8 None 10.1021/jm200757g
None NON-PROTEIN TARGET Log IC50 -9.0 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -8.7 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -8.2 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -8.0 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -7.7 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -7.5 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -7.4 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -7.1 nM 10.1021/jm049405a
None NON-PROTEIN TARGET Log IC50 -5.0 nM 10.1021/jm049405a
None NON-PROTEIN TARGET PC50 100.0 uM 10.1016/j.bmc.2013.10.027
None NON-PROTEIN TARGET PC50 100.0 uM 10.1021/acs.jnatprod.6b00381
None NON-PROTEIN TARGET PC50 200.0 uM 10.1016/j.bmcl.2013.12.044
None NON-PROTEIN TARGET Potency 22.4 nM None
None NON-PROTEIN TARGET Potency 70.8 nM None
None NON-PROTEIN TARGET Potency 100.0 nM None
None NON-PROTEIN TARGET Potency 158.5 nM None
None NON-PROTEIN TARGET Potency 251.2 nM None
None NON-PROTEIN TARGET Potency 1584.9 nM None
None NON-PROTEIN TARGET Ratio 1.0 None 10.1016/0960-894X(95)00083-6
None NON-PROTEIN TARGET Ratio 1.0 None 10.1016/s0960-894x(00)00242-0
None NON-PROTEIN TARGET Ratio 1.0 None 10.1016/S0960-894X(01)80507-2
None NON-PROTEIN TARGET Ratio 1.0 None 10.1021/jm00046a018
None NON-PROTEIN TARGET Ratio 2.0 None 10.1021/jm00107a017
None NON-PROTEIN TARGET Ratio 455.0 None 10.1016/s0960-894x(02)00891-0
None NON-PROTEIN TARGET Ratio 1000.0 None 10.1016/s0960-894x(02)00891-0
None NON-PROTEIN TARGET Ratio IC50 100.0 None 10.1021/jm300176j
None NON-PROTEIN TARGET Ratio IC50 124.0 None 10.1021/jm500024v
None NON-PROTEIN TARGET Ratio IC50 338.0 None 10.1016/j.bmcl.2011.01.111
None NON-PROTEIN TARGET Survival 18.9 % 10.1016/j.bmcl.2016.04.069
None NON-PROTEIN TARGET T/C 0.0 % 10.1021/jm200757g
None NON-PROTEIN TARGET TGI 24.8 % 10.1016/j.bmcl.2016.11.020
None NON-PROTEIN TARGET TGI 30.0 nM 10.1016/j.ejmech.2014.03.086
None NON-PROTEIN TARGET TGI 43.5 % 10.1016/j.bmc.2013.02.002
None NON-PROTEIN TARGET TGI 53.0 % None
None NON-PROTEIN TARGET TGI 150.0 nM 10.1021/np970266s
None NON-PROTEIN TARGET TGI 400.0 nM 10.1016/j.ejmech.2014.03.086
None NON-PROTEIN TARGET TGI 500.0 nM 10.1016/j.ejmech.2014.03.086
None NON-PROTEIN TARGET TIME 456.0 hr 10.1021/jm200757g
None No relevant target Activity 85.2 % 10.1016/j.bmcl.2007.04.058
None No relevant target Drug metabolism nan None 10.1021/acsmedchemlett.7b00189
None No relevant target LogD 3.6 None 10.1016/j.bmcl.2019.03.053
None No relevant target LogP 0.017 None 10.1021/np010552a
None No relevant target LogP 0.54 None 10.1021/jm101655d
None No relevant target LogP 2.25 None 10.1016/j.bmc.2012.07.031
None No relevant target LogP 3.0 None 10.1016/j.ejmech.2009.12.043
None No relevant target pKa nan None 10.1021/jm030408h
None No relevant target Retention_time 10.5 min 10.1021/jm401708f
None No relevant target Retention_time 11.0 min 10.1021/acs.jmedchem.5b01971
None No relevant target Retention_time 13.81 min 10.1016/j.bmc.2019.02.046
None No relevant target Solubility 0.021 ug.mL-1 10.1021/jm100884b
None No relevant target Solubility 0.137 ug.mL-1 10.1021/jm100884b
None No relevant target Solubility 0.25 ug.mL-1 10.1016/j.bmc.2008.04.022
None No relevant target Solubility 0.25 ug.mL-1 10.1016/j.bmcl.2016.06.012
None No relevant target Solubility 0.25 ug.mL-1 10.1016/S0960-894X(00)80348-0
None No relevant target Solubility 0.25 ug.mL-1 10.1016/s0960-894x(02)00694-7
None No relevant target Solubility 0.3 ug.mL-1 10.1021/acs.jnatprod.7b00857
None No relevant target Solubility 0.3 ug.mL-1 10.1021/jm960505t
None No relevant target Solubility 0.4 ug.mL-1 10.1021/jm8006257
None No relevant target Solubility 4.0 ug.mL-1 10.1016/j.bmcl.2006.11.008
None No relevant target Solubility 4.0 ug.mL-1 10.1016/j.bmcl.2014.10.088
None No relevant target Solubility 4.0 ug.mL-1 10.1016/j.ejmech.2019.03.031
None No relevant target Solubility 4.0 ug.mL-1 10.1016/s0960-894x(02)00628-5
None No relevant target Solubility 10.0 ug.mL-1 10.1016/j.bmc.2007.03.041
None No relevant target Solubility 10.0 ug.mL-1 10.1016/j.bmcl.2006.02.035
None No relevant target Solubility 350.0 nM 10.1021/acsmedchemlett.7b00117
None No relevant target Solubility 1000.0 None 10.1021/jm00107a042
None No relevant target Solubility 35000.0 nM 10.1021/jm00079a019
None No relevant target Solubility 35000.0 nM 10.1021/jm00107a042
None No relevant target Stability 70.28 % 10.1021/acs.jmedchem.1c00705
None No relevant target Stability nan % 10.1016/j.bmcl.2017.12.032
None No relevant target T1/2 60.0 hr 10.1016/j.bmcl.2007.04.058
None Panel (10 carcinoma cell lines) Inhibition nan % 10.1016/j.bmcl.2006.03.029
None Unchecked Ac50 2.512 uM None
None Unchecked Ac50 10.0 uM None
None Unchecked Ac50 22.39 uM None
None Unchecked AC50 2511.9 nM None
None Unchecked AC50 3590.0 nM None
None Unchecked AC50 10000.0 nM None
None Unchecked AC50 22387.2 nM None
None Unchecked Activity 1.0 None 10.1016/S0960-894X(97)00329-6
None Unchecked Activity 2.0 % 10.1038/nchembio853
None Unchecked Activity 2.1 % 10.1016/j.ejmech.2020.113107
None Unchecked Activity 2.3 % 10.1021/np010552a
None Unchecked Activity 2.31 % 10.1016/j.bmcl.2020.127715
None Unchecked Activity 4.0 % 10.1038/nchembio853
None Unchecked Activity 4.23 uM 10.1016/j.bmcl.2008.12.018
None Unchecked Activity 5.36 uM 10.1016/j.ejmech.2017.06.001
None Unchecked Activity 7.15 % 10.1016/j.bmcl.2020.127715
None Unchecked Activity 7.2 % 10.1038/nchembio853
None Unchecked Activity 8.0 % 10.1038/nchembio853
None Unchecked Activity 10.0 % 10.1016/j.bmcl.2017.10.057
None Unchecked Activity 10.0 % 10.1038/nchembio853
None Unchecked Activity 11.8 % 10.1021/acs.jmedchem.1c00715
None Unchecked Activity 12.0 % 10.1038/nchembio853
None Unchecked Activity 13.0 % 10.1038/nchembio853
None Unchecked Activity 14.2 % 10.1038/nchembio853
None Unchecked Activity 15.0 % 10.1038/nchembio853
None Unchecked Activity 15.0 nM 10.1016/j.ejmech.2017.06.001
None Unchecked Activity 15.8 % 10.1021/acs.jnatprod.8b00111
None Unchecked Activity 16.0 % 10.1038/nchembio853
None Unchecked Activity 18.0 % 10.1021/acs.jnatprod.7b01047
None Unchecked Activity 18.6 % 10.1016/j.bmcl.2020.127715
None Unchecked Activity 19.0 % 10.1038/nchembio853
None Unchecked Activity 20.0 % 10.1021/jm900254k
None Unchecked Activity 20.0 % 10.1038/nchembio853
None Unchecked Activity 22.63 % 10.1016/j.ejmech.2022.114207
None Unchecked Activity 27.0 % 10.1038/nchembio853
None Unchecked Activity 28.0 % 10.1038/nchembio853
None Unchecked Activity 30.0 % 10.1021/acs.jmedchem.6b00777
None Unchecked Activity 33.0 % 10.1038/nchembio853
None Unchecked Activity 34.5 % 10.1021/acs.jmedchem.9b00706
None Unchecked Activity 37.0 % 10.1021/jm0204136
None Unchecked Activity 42.0 % 10.1021/jm900254k
None Unchecked Activity 43.0 % 10.1038/nchembio853
None Unchecked Activity 45.0 % 10.1038/nchembio853
None Unchecked Activity 50.0 % 10.1021/np50098a016
None Unchecked Activity 50.0 % 10.1038/nchembio853
None Unchecked Activity 51.0 % 10.1016/j.bmc.2017.10.045
None Unchecked Activity 59.6 % 10.1038/nchembio853
None Unchecked Activity 59.7 % 10.1021/acs.jmedchem.1c01451
None Unchecked Activity 62.0 % 10.1038/nchembio853
None Unchecked Activity 66.0 % 10.1021/np010552a
None Unchecked Activity 72.0 % 10.1016/j.bmcl.2020.127715
None Unchecked Activity 72.7 % 10.1016/j.ejmech.2018.11.070
None Unchecked Activity 79.0 % 10.1021/jm900254k
None Unchecked Activity 79.8 % 10.1021/acs.jmedchem.1c01451
None Unchecked Activity 91.6 % 10.1021/acsmedchemlett.9b00526
None Unchecked Activity 94.0 % 10.1016/j.bmc.2017.10.045
None Unchecked Activity 100.0 % 10.1021/np010552a
None Unchecked Activity 868.7 mm3 10.1016/j.ejmech.2019.111584
None Unchecked Activity nan None 10.1016/j.bmc.2008.04.071
None Unchecked Activity nan None 10.1016/j.bmc.2008.06.028
None Unchecked Activity nan None 10.1016/j.bmc.2010.06.014
None Unchecked Activity nan None 10.1016/j.bmc.2010.11.054
None Unchecked Activity nan None 10.1016/j.bmc.2011.05.030
None Unchecked Activity nan None 10.1016/j.bmc.2011.10.010
None Unchecked Activity nan None 10.1016/j.bmc.2013.12.067
None Unchecked Activity nan None 10.1016/j.bmc.2014.05.048
None Unchecked Activity nan None 10.1016/j.bmc.2015.12.042
None Unchecked Activity nan None 10.1016/j.bmc.2017.07.048
None Unchecked Activity nan None 10.1016/j.bmc.2017.11.023
None Unchecked Activity nan None 10.1016/j.bmcl.2008.07.068
None Unchecked Activity nan None 10.1016/j.bmcl.2009.05.093
None Unchecked Activity nan None 10.1016/j.bmcl.2017.07.047
None Unchecked Activity nan None 10.1016/j.ejmech.2010.07.050
None Unchecked Activity nan None 10.1016/j.ejmech.2014.07.035
None Unchecked Activity nan None 10.1016/j.ejmech.2015.10.052
None Unchecked Activity nan None 10.1016/j.ejmech.2016.06.007
None Unchecked Activity nan None 10.1016/j.ejmech.2016.07.002
None Unchecked Activity nan None 10.1016/j.ejmech.2016.09.048
None Unchecked Activity nan None 10.1016/j.ejmech.2017.07.040
None Unchecked Activity nan None 10.1016/j.ejmech.2017.08.018
None Unchecked Activity nan None 10.1016/j.ejmech.2017.11.011
None Unchecked Activity nan None 10.1016/j.ejmech.2017.12.004
None Unchecked Activity nan None 10.1016/j.ejmech.2017.12.008
None Unchecked Activity nan None 10.1016/j.ejmech.2017.12.019
None Unchecked Activity nan None 10.1016/j.ejmech.2018.09.017
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112105
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112308
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112519
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112716
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112756
None Unchecked Activity nan None 10.1016/j.ejmech.2020.113068
None Unchecked Activity nan None 10.1016/j.ejmech.2021.113653
None Unchecked Activity nan None 10.1016/j.ejmech.2021.113746
None Unchecked Activity nan None 10.1016/j.ejmech.2022.114207
None Unchecked Activity nan None 10.1016/j.ejmech.2022.114372
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c00404
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c02159
None Unchecked Activity nan None 10.1021/acs.jmedchem.6b00777
None Unchecked Activity nan None 10.1021/acs.jmedchem.6b01264
None Unchecked Activity nan None 10.1021/acs.jmedchem.7b01858
None Unchecked Activity nan None 10.1021/acs.jmedchem.8b00827
None Unchecked Activity nan None 10.1021/acs.jnatprod.7b01047
None Unchecked Activity nan None 10.1021/acs.jnatprod.8b00641
None Unchecked Activity nan None 10.1021/acsmedchemlett.0c00534
None Unchecked Activity nan None 10.1021/jm070890u
None Unchecked Activity nan None 10.1021/jm200757g
None Unchecked Activity nan None 10.1021/jm400479p
None Unchecked Activity nan None 10.1021/jm400575x
None Unchecked Activity nan None 10.1021/jm400842x
None Unchecked Activity nan None 10.1021/jm701499n
None Unchecked Activity nan None 10.1021/ml200195s
None Unchecked Activity nan None 10.1021/ml300149z
None Unchecked Activity nan None 10.1021/np0500880
None Unchecked Activity nan None 10.1021/np050543s
None Unchecked Activity nan None 10.1021/np4002702
None Unchecked Activity nan None 10.1021/np50098a016
None Unchecked Activity nan None 10.1021/np800056m
None Unchecked Activity nan None 10.1021/np800496c
None Unchecked Activity nan None 10.1038/nchembio853
None Unchecked Activity nan None 10.1126/science.1159961
None Unchecked CC50 10.0 nM 10.1016/j.bmcl.2019.126779
None Unchecked Control 56.0 % 10.1016/S0960-894X(97)00029-2
None Unchecked Control 83.0 % 10.1016/S0960-894X(97)00029-2
None Unchecked Control 132.0 % 10.1016/S0960-894X(97)00029-2
None Unchecked Control 138.0 % 10.1016/S0960-894X(97)00029-2
None Unchecked DOSE 30.0 mg.kg-1 10.1016/s0960-894x(02)00784-9
None Unchecked EC50 39.0 nM None
None Unchecked EC50 69.0 nM None
None Unchecked EC50 86.0 nM None
None Unchecked EC50 100.0 nM None
None Unchecked EC50 970.0 nM 10.1016/j.bmcl.2016.09.036
None Unchecked EC50 10555.0 nM None
None Unchecked EC50 nan None 10.1016/j.bmc.2015.03.061
None Unchecked EC50 nan None 10.1016/j.bmc.2016.09.062
None Unchecked EC50 nan None 10.1016/j.bmc.2017.04.012
None Unchecked ED50 0.48 uM 10.1016/j.bmcl.2009.03.063
None Unchecked ED50 0.52 uM 10.1016/j.bmcl.2008.12.091
None Unchecked ED50 0.7 uM 10.1016/S0960-894X(01)80203-1
None Unchecked ED50 0.76 uM 10.1021/np50103a016
None Unchecked ED50 0.93 uM 10.1021/jm00050a023
None Unchecked ED50 0.95 uM 10.1021/np50103a016
None Unchecked ED50 1.2 uM 10.1016/j.bmcl.2008.10.010
None Unchecked ED50 ratio 1.0 None 10.1016/S0960-894X(01)80378-4
None Unchecked ED50 ratio 1.0 None 10.1016/S0960-894X(01)80379-6
None Unchecked FC 0.5 None 10.1016/j.ejmech.2012.01.004
None Unchecked FC 2.68 None 10.1016/j.ejmech.2017.07.076
None Unchecked GI50 0.539 ug.mL-1 10.1021/acs.jmedchem.1c00790
None Unchecked GI50 5.0 nM 10.1016/j.bmc.2020.115887
None Unchecked GI50 7.53 nM 10.1016/j.bmcl.2017.10.057
None Unchecked GI50 10.0 nM 10.1016/j.ejmech.2020.112044
None Unchecked GI50 21.0 nM 10.1016/j.bmcl.2017.10.057
None Unchecked GI50 935.3 nM 10.1021/acs.jmedchem.0c01345
None Unchecked GI50 1565.0 nM 10.1021/acsmedchemlett.1c00505
None Unchecked GI50 1960.0 nM 10.1021/acsmedchemlett.9b00352
None Unchecked GI50 2716.0 nM 10.1021/acs.jmedchem.7b00273
None Unchecked Hepatotoxicity (acute) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.1 nM 10.1021/acs.jmedchem.5b01380
None Unchecked IC50 0.5 nM 10.1021/jm800386y
None Unchecked IC50 1.5 nM 10.1016/j.bmc.2019.115301
None Unchecked IC50 2.0 nM 10.1021/acs.jnatprod.8b00677
None Unchecked IC50 3.0 nM 10.1016/j.bmc.2019.115281
None Unchecked IC50 3.0 nM 10.1016/j.bmcl.2018.02.051
None Unchecked IC50 3.1 nM 10.1016/s0960-894x(99)00629-0
None Unchecked IC50 5.7 nM 10.1021/acs.jnatprod.1c01050
None Unchecked IC50 6.3 nM 10.1021/acs.jmedchem.7b00958
None Unchecked IC50 8.0 nM 10.1021/acs.jnatprod.5b01073
None Unchecked IC50 9.0 nM 10.1016/j.ejmech.2017.06.001
None Unchecked IC50 12.1 nM 10.1016/j.bmc.2018.02.024
None Unchecked IC50 18.0 nM 10.1016/j.ejmech.2022.114112
None Unchecked IC50 19.7 nM 10.1016/j.ejmech.2017.06.001
None Unchecked IC50 20.0 nM 10.1021/acs.jnatprod.5b01073
None Unchecked IC50 24.0 nM 10.1016/j.bmcl.2018.07.039
None Unchecked IC50 30.0 nM 10.1016/j.bmcl.2018.02.051
None Unchecked IC50 40.0 nM 10.1128/aac.00355-07
None Unchecked IC50 41.0 nM 10.1021/acs.jnatprod.7b00857
None Unchecked IC50 50.0 nM 10.1021/acs.jmedchem.1c01202
None Unchecked IC50 70.0 nM 10.1016/j.bmcl.2018.02.006
None Unchecked IC50 101.0 nM 10.1016/j.ejmech.2019.111584
None Unchecked IC50 103.8 nM 10.1021/acs.jmedchem.1c01202
None Unchecked IC50 105.0 nM 10.1021/acs.jmedchem.1c00715
None Unchecked IC50 110.7 nM 10.1021/acs.jmedchem.7b01858
None Unchecked IC50 112.1 nM 10.1021/acs.jmedchem.1c00715
None Unchecked IC50 113.9 nM 10.1021/acs.jmedchem.8b00827
None Unchecked IC50 113.9 nM 10.1021/acs.jmedchem.9b00706
None Unchecked IC50 148.4 nM 10.1021/acs.jmedchem.9b01815
None Unchecked IC50 180.0 nM 10.1021/acs.jmedchem.2c00608
None Unchecked IC50 200.0 nM 10.1021/acs.jmedchem.7b00958
None Unchecked IC50 200.2 nM 10.1021/acs.jmedchem.9b01815
None Unchecked IC50 250.0 nM 10.1016/j.ejmech.2018.02.045
None Unchecked IC50 306.2 nM 10.1021/acs.jmedchem.1c01202
None Unchecked IC50 344.0 nM 10.1016/j.ejmech.2021.113897
None Unchecked IC50 346.0 nM 10.1016/s0960-894x(99)00629-0
None Unchecked IC50 346.0 nM 10.1021/acs.jmedchem.7b01457
None Unchecked IC50 420.0 nM 10.1021/np50098a016
None Unchecked IC50 500.0 nM 10.1016/j.ejmech.2022.114112
None Unchecked IC50 500.0 nM 10.1021/np0000872
None Unchecked IC50 500.0 nM 10.1021/np050543s
None Unchecked IC50 510.0 nM 10.1016/j.bmcl.2016.07.059
None Unchecked IC50 550.0 nM 10.1021/np010552a
None Unchecked IC50 650.0 nM 10.1016/j.ejmech.2019.01.005
None Unchecked IC50 700.0 nM 10.1016/j.ejmech.2018.11.004
None Unchecked IC50 708.0 nM 10.1016/j.ejmech.2019.111584
None Unchecked IC50 778.24 nM 10.1016/j.ejmech.2020.113107
None Unchecked IC50 857.0 nM 10.1016/j.ejmech.2019.111584
None Unchecked IC50 1000.0 nM 10.1016/j.bmc.2015.12.042
None Unchecked IC50 1000.0 nM 10.1021/acs.jmedchem.7b01858
None Unchecked IC50 1000.0 nM 10.1021/acs.jmedchem.9b00706
None Unchecked IC50 1000.0 nM 10.1021/acs.jmedchem.9b01815
None Unchecked IC50 1000.0 nM 10.1021/jm0497996
None Unchecked IC50 1010.0 nM 10.1016/j.ejmech.2018.05.025
None Unchecked IC50 1017.0 nM 10.1016/j.ejmech.2022.114466
None Unchecked IC50 1100.0 nM 10.1021/acs.jnatprod.6b00972
None Unchecked IC50 1200.0 nM 10.1016/j.bmc.2018.09.025
None Unchecked IC50 1200.0 nM 10.1016/j.bmcl.2018.07.039
None Unchecked IC50 1282.0 nM 10.1016/j.ejmech.2017.06.001
None Unchecked IC50 1400.0 nM 10.1021/acs.jnatprod.6b00972
None Unchecked IC50 1530.0 nM 10.1016/j.ejmech.2017.03.031
None Unchecked IC50 1584.0 nM 10.1016/j.bmc.2020.115736
None Unchecked IC50 1590.0 nM 10.1016/j.ejmech.2018.01.020
None Unchecked IC50 1600.0 nM 10.1021/acs.jnatprod.8b00677
None Unchecked IC50 1669.0 nM 10.1021/acs.jmedchem.2c01595
None Unchecked IC50 1680.0 nM 10.1016/j.ejmech.2019.06.086
None Unchecked IC50 1860.0 nM 10.1021/acs.jnatprod.7b00578
None Unchecked IC50 1896.0 nM 10.1021/acs.jnatprod.6b00645
None Unchecked IC50 1926.0 nM 10.1021/acs.jnatprod.6b01151
None Unchecked IC50 1926.0 nM 10.1021/acs.jnatprod.6b01153
None Unchecked IC50 2035.0 nM 10.1016/j.bmcl.2017.04.055
None Unchecked IC50 2100.0 nM 10.1021/acs.jnatprod.8b01006
None Unchecked IC50 2105.0 nM 10.1016/j.ejmech.2021.113578
None Unchecked IC50 2117.0 nM 10.1021/acs.jnatprod.6b01099
None Unchecked IC50 2300.0 nM 10.1021/acs.jmedchem.1c01452
None Unchecked IC50 2300.0 nM 10.1021/acs.jnatprod.9b00140
None Unchecked IC50 2330.0 nM 10.1016/j.bmc.2017.04.012
None Unchecked IC50 2353.0 nM 10.1021/acs.jnatprod.0c00454
None Unchecked IC50 2360.0 nM 10.1021/acs.jnatprod.7b00949
None Unchecked IC50 2383.0 nM 10.1021/acs.jnatprod.8b00411
None Unchecked IC50 2400.0 nM 10.1016/j.bmc.2008.03.069
None Unchecked IC50 2540.0 nM 10.1016/j.bmcl.2021.128319
None Unchecked IC50 2590.0 nM 10.1016/j.ejmech.2018.11.070
None Unchecked IC50 2600.0 nM 10.1016/j.bmc.2018.04.010
None Unchecked IC50 2600.0 nM 10.1016/j.bmc.2020.115887
None Unchecked IC50 2750.0 nM 10.1021/acs.jmedchem.2c01595
None Unchecked IC50 2786.0 nM 10.1021/acs.jnatprod.8b00211
None Unchecked IC50 2879.0 nM 10.1021/acs.jnatprod.8b00411
None Unchecked IC50 2897.9 nM 10.1016/j.bmc.2019.05.016
None Unchecked IC50 2920.0 nM 10.1016/j.ejmech.2022.114372
None Unchecked IC50 3000.0 nM 10.1021/acs.jnatprod.8b00411
None Unchecked IC50 3145.83 nM 10.1016/j.ejmech.2019.111696
None Unchecked IC50 3733.0 nM 10.1021/acs.jnatprod.7b01047
None Unchecked IC50 4000.0 nM 10.1016/j.ejmech.2018.07.029
None Unchecked IC50 4531.0 nM 10.1021/acs.jnatprod.9b00596
None Unchecked IC50 7140.0 nM 10.1016/j.ejmech.2016.10.012
None Unchecked IC50 8350.0 nM 10.1016/j.ejmech.2022.114372
None Unchecked IC50 9600.0 nM 10.1016/j.ejmech.2020.113068
None Unchecked IC50 9885.0 nM 10.1016/j.ejmech.2017.07.040
None Unchecked IC50 10000.0 nM 10.1021/acs.jnatprod.9b00659
None Unchecked IC50 10000.0 nM 10.1128/aac.00355-07
None Unchecked IC50 10400.0 nM 10.1016/j.bmc.2018.02.024
None Unchecked IC50 11000.0 nM 10.1021/acs.jnatprod.6b00972
None Unchecked IC50 11000.0 nM None
None Unchecked IC50 11200.0 nM 10.1021/acs.jnatprod.6b00972
None Unchecked IC50 11300.0 nM 10.1016/j.ejmech.2020.113068
None Unchecked IC50 12500.0 nM 10.1016/j.bmc.2018.02.024
None Unchecked IC50 12590.0 nM 10.1021/acs.jnatprod.7b01047
None Unchecked IC50 13100.0 nM 10.1016/j.bmc.2019.115180
None Unchecked IC50 16040.0 nM 10.1021/acs.jnatprod.7b00857
None Unchecked IC50 21228.0 nM 10.1021/acs.jnatprod.7b01047
None Unchecked IC50 22200.0 nM 10.1021/acs.jnatprod.7b01047
None Unchecked IC50 23900.0 nM 10.1016/j.ejmech.2020.113050
None Unchecked IC50 36497.0 nM 10.1016/j.ejmech.2019.111696
None Unchecked IC50 63000.0 nM 10.1016/j.bmcl.2019.02.028
None Unchecked IC50 78880.0 nM 10.1021/acsmedchemlett.0c00131
None Unchecked IC50 78880.0 nM 10.1021/acsmedchemlett.3c00019
None Unchecked IC50 80000.0 nM None
None Unchecked IC50 152300.0 nM 10.1021/acs.jnatprod.7b01047
None Unchecked IC50 200000.0 nM 10.1016/j.ejmech.2019.01.076
None Unchecked IC50 240000.0 nM 10.1021/acs.jnatprod.7b01047
None Unchecked IC50 250000.0 nM 10.1021/acs.jnatprod.7b00006
None Unchecked IC50 1650000.0 nM 10.1039/C7MD00310B
None Unchecked IC50 1720000.0 nM 10.1016/j.bmc.2016.09.062
None Unchecked IC50 1727400.0 nM 10.1016/j.ejmech.2018.08.069
None Unchecked IC50 1855494.0 nM 10.1016/j.ejmech.2017.02.025
None Unchecked IC50 nan None 10.1016/j.bmc.2013.11.018
None Unchecked IC50 nan None 10.1016/j.bmcl.2018.11.023
None Unchecked IC50 nan None 10.1016/j.ejmech.2014.10.013
None Unchecked IC50 nan None 10.1016/j.ejmech.2018.11.070
None Unchecked IC50 nan None None
None Unchecked IC50 ratio nan None 10.1016/S0960-894X(01)80568-0
None Unchecked IC99 230.0 nM 10.1016/s0960-894x(00)00150-5
None Unchecked ID50 0.1 uM 10.1021/np50067a001
None Unchecked ID50 0.29 uM 10.1021/np50099a010
None Unchecked Imax 74.0 % 10.1021/acs.jmedchem.2c01348
None Unchecked Inhibition 9.0 % 10.1021/acs.jnatprod.7b01047
None Unchecked Inhibition 40.0 % 10.1038/nchembio853
None Unchecked Inhibition 49.0 % 10.1016/j.ejmech.2019.03.031
None Unchecked Inhibition 54.0 % 10.1016/j.ejmech.2020.112323
None Unchecked Inhibition 65.0 % 10.1016/j.ejmech.2020.112323
None Unchecked Inhibition 75.0 % 10.1016/j.ejmech.2020.112323
None Unchecked Inhibition 90.4 % 10.1021/acs.jmedchem.8b01755
None Unchecked Inhibition 100.0 % 10.1021/jm061385k
None Unchecked Inhibition nan % 10.1016/j.bmc.2009.01.042
None Unchecked Inhibition nan % 10.1016/j.bmc.2010.02.012
None Unchecked Inhibition nan % 10.1016/j.bmc.2011.08.044
None Unchecked Inhibition nan % 10.1016/j.bmc.2016.09.062
None Unchecked Inhibition nan % 10.1016/j.bmc.2016.12.010
None Unchecked Inhibition nan % 10.1016/j.bmc.2017.04.013
None Unchecked Inhibition nan % 10.1016/j.bmc.2017.05.057
None Unchecked Inhibition nan % 10.1016/j.bmc.2019.115154
None Unchecked Inhibition nan % 10.1016/j.bmcl.2003.12.015
None Unchecked Inhibition nan % 10.1016/j.bmcl.2012.04.074
None Unchecked Inhibition nan % 10.1016/j.bmcl.2017.04.082
None Unchecked Inhibition nan % 10.1016/j.bmcl.2017.07.069
None Unchecked Inhibition nan % 10.1016/j.ejmech.2014.07.035
None Unchecked Inhibition nan % 10.1016/j.ejmech.2016.09.013
None Unchecked Inhibition nan % 10.1016/j.ejmech.2017.02.021
None Unchecked Inhibition nan % 10.1016/j.ejmech.2017.03.031
None Unchecked Inhibition nan % 10.1016/j.ejmech.2017.12.004
None Unchecked Inhibition nan % 10.1016/j.ejmech.2018.05.058
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.113058
None Unchecked Inhibition nan % 10.1016/j.ejmech.2020.113117
None Unchecked Inhibition nan % 10.1016/j.ejmech.2022.114112
None Unchecked Inhibition nan % 10.1016/j.ejmech.2022.114583
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.1c01202
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b01840
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.9b01100
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.7b01047
None Unchecked Inhibition nan % 10.1021/acs.jnatprod.8b00557
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.1c00219
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.1c00544
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.5b00418
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.6b00483
None Unchecked Inhibition nan % 10.1021/jm1000979
None Unchecked Inhibition nan % 10.1021/jm200410r
None Unchecked Inhibition nan % 10.1021/jm200757g
None Unchecked Inhibition nan % 10.1021/jm300176j
None Unchecked Inhibition nan % 10.1021/jm901805m
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Inhibition nan % 10.1038/nchembio.94
None Unchecked Inhibition nan % 10.1039/C6MD00255B
None Unchecked Kb 0.94 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 0.96 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 1.07 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 1.43 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 1.81 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 1.83 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 2.19 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 2.64 10'7/M 10.1016/j.bmc.2014.05.048
None Unchecked Kb 3.3 10'6/M 10.1021/acs.jnatprod.7b00857
None Unchecked Kd 4.76 10'7/M 10.1016/j.bmcl.2009.03.063
None Unchecked Kd 15.0 nM 10.1016/j.bmc.2011.06.082
None Unchecked Kd 35.0 nM 10.1016/j.bmcl.2011.06.034
None Unchecked Kd 56.0 nM 10.1016/j.bmcl.2011.06.034
None Unchecked Kd 70.0 nM 10.1038/nchembio853
None Unchecked Ki nan None None
None Unchecked LC50 10.0 nM 10.1021/acs.jmedchem.2c01348
None Unchecked Potency 8.2 nM None
None Unchecked Potency 9.2 nM None
None Unchecked Potency 12.6 nM None
None Unchecked Potency 251.2 nM None
None Unchecked Potency 501.2 nM None
None Unchecked Potency 1122.0 nM None
None Unchecked Potency 1299.0 nM None
None Unchecked Potency 2238.7 nM None
None Unchecked Potency 2818.4 nM None
None Unchecked Potency 3162.3 nM None
None Unchecked Potency 4109.5 nM None
None Unchecked Potency 4466.8 nM None
None Unchecked Potency 6309.6 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Potency 31622.8 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Ratio 0.605 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.7 None 10.1016/S0960-894X(00)80469-2
None Unchecked Ratio 0.9 None 10.1021/jm034146v
None Unchecked Ratio 1.0 None 10.1016/s0960-894x(00)00242-0
None Unchecked Ratio 1.0 None 10.1021/jm00009a009
None Unchecked Ratio 1.0 None 10.1021/jm00044a020
None Unchecked Ratio 1.0 None 10.1021/jm00050a023
None Unchecked Ratio 1.0 None 10.1021/jm00100a031
None Unchecked Ratio 1.0 None 10.1021/jm0102607
None Unchecked Ratio 1.0 None 10.1021/jm201121b
None Unchecked Ratio 2.0 None 10.1021/jm00107a017
None Unchecked Ratio 5.9 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio 10.8 None 10.1016/0960-894X(95)00300-I
None Unchecked Ratio 24.8 None 10.1016/j.bmcl.2003.12.015
None Unchecked Ratio 25.0 None 10.1021/acsmedchemlett.0c00534
None Unchecked Ratio 70.06 None 10.1021/acs.jmedchem.1c00715
None Unchecked Ratio 112.0 None 10.1021/np8006556
None Unchecked Ratio 131.0 None 10.1016/s0960-894x(00)00242-0
None Unchecked Ratio 131.25 None 10.1021/acs.jmedchem.1c00715
None Unchecked Ratio 176.0 None 10.1021/jm034146v
None Unchecked Ratio 176.0 None 10.1021/jm960563e
None Unchecked Ratio 200.0 None 10.1021/jm0102607
None Unchecked Ratio 372.6 None 10.1021/acs.jmedchem.1c00715
None Unchecked Ratio 507.0 None 10.1021/jm034146v
None Unchecked Ratio 849.0 None 10.1021/jm034146v
None Unchecked Ratio nan None 10.1016/j.bmc.2015.03.061
None Unchecked Ratio nan None 10.1016/j.bmc.2017.04.012
None Unchecked Ratio EC50 10.6 None 10.1016/j.bmcl.2021.127923
None Unchecked Ratio ED50 1.0 None 10.1016/j.bmcl.2008.09.103
None Unchecked RatioGI50 0.0067 None 10.1016/j.bmcl.2015.02.018
None Unchecked RatioGI50 12.0 None 10.1021/acs.jmedchem.0c01345
None Unchecked RatioGI50 100.0 None 10.1021/jm060968r
None Unchecked RatioGI50 246.0 None 10.1021/acs.jmedchem.0c01345
None Unchecked Ratio IC50 0.001 None 10.1021/acs.jnatprod.8b00677
None Unchecked Ratio IC50 0.002 None 10.1016/j.bmcl.2014.08.063
None Unchecked Ratio IC50 0.002 None 10.1021/acs.jnatprod.8b00677
None Unchecked Ratio IC50 0.015 None 10.1021/acs.jnatprod.8b00677
None Unchecked Ratio IC50 0.02 None 10.1016/j.ejmech.2019.01.005
None Unchecked Ratio IC50 0.03 None 10.1016/j.ejmech.2019.01.005
None Unchecked Ratio IC50 0.05 None 10.1021/acs.jnatprod.8b00677
None Unchecked Ratio IC50 0.06 None 10.1016/j.ejmech.2019.01.005
None Unchecked Ratio IC50 0.2 None 10.1021/acs.jmedchem.8b01424
None Unchecked Ratio IC50 0.52 None 10.1016/j.ejmech.2021.113685
None Unchecked Ratio IC50 0.6 None 10.1016/j.bmcl.2018.02.051
None Unchecked Ratio IC50 0.86 None 10.1021/acsmedchemlett.7b00189
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmcl.2019.02.028
None Unchecked Ratio IC50 1.0 None 10.1021/acs.jmedchem.8b01742
None Unchecked Ratio IC50 1.52 None 10.1016/j.ejmech.2017.03.055
None Unchecked Ratio IC50 1.6 None 10.1021/acs.jmedchem.1c00404
None Unchecked Ratio IC50 2.0 None 10.1021/jm900016t
None Unchecked Ratio IC50 2.4 None 10.1021/acs.jmedchem.1c00404
None Unchecked Ratio IC50 2.9 None 10.1021/acs.jmedchem.8b01742
None Unchecked Ratio IC50 3.91 None 10.1016/j.ejmech.2019.06.086
None Unchecked Ratio IC50 4.7 None 10.1016/j.bmc.2020.115887
None Unchecked Ratio IC50 4.7 None 10.1021/jm400639z
None Unchecked Ratio IC50 5.1 None 10.1021/acs.jmedchem.6b00158
None Unchecked Ratio IC50 6.5 None 10.1021/acs.jmedchem.1c01775
None Unchecked Ratio IC50 8.0 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio IC50 8.6 None 10.1016/j.bmc.2018.09.025
None Unchecked Ratio IC50 8.6 None 10.1016/j.bmc.2021.116061
None Unchecked Ratio IC50 8.6 None 10.1016/j.bmc.2023.117217
None Unchecked Ratio IC50 8.6 None 10.1016/j.bmcl.2018.07.039
None Unchecked Ratio IC50 8.9 None 10.1021/acs.jnatprod.7b00857
None Unchecked Ratio IC50 10.0 None 10.1016/j.bmcl.2018.02.006
None Unchecked Ratio IC50 10.0 None 10.1016/j.ejmech.2019.111584
None Unchecked Ratio IC50 11.2 None 10.1021/acs.jmedchem.2c01595
None Unchecked Ratio IC50 13.5 None 10.1021/acs.jmedchem.1c01775
None Unchecked Ratio IC50 16.4 None 10.1016/j.ejmech.2021.113897
None Unchecked Ratio IC50 16.7 None 10.1021/acsmedchemlett.3c00019
None Unchecked Ratio IC50 19.6 None 10.1016/j.ejmech.2017.06.001
None Unchecked Ratio IC50 23.7 None 10.1021/acs.jmedchem.8b01742
None Unchecked Ratio IC50 30.0 None 10.1021/acs.jmedchem.7b01858
None Unchecked Ratio IC50 32.76 None 10.1016/j.ejmech.2018.05.003
None Unchecked Ratio IC50 33.1 None 10.1021/acs.jmedchem.1c02159
None Unchecked Ratio IC50 50.0 None 10.1016/j.bmcl.2018.02.006
None Unchecked Ratio IC50 50.3 None 10.1016/j.ejmech.2022.114372
None Unchecked Ratio IC50 56.0 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio IC50 65.67 None 10.1016/j.ejmech.2018.02.045
None Unchecked Ratio IC50 69.3 None 10.1021/jm4001117
None Unchecked Ratio IC50 70.0 None 10.1016/j.ejmech.2019.111584
None Unchecked Ratio IC50 79.4 None 10.1021/acs.jmedchem.9b01815
None Unchecked Ratio IC50 89.0 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio IC50 92.0 None 10.1021/acs.jmedchem.8b01742
None Unchecked Ratio IC50 92.5 None 10.1016/j.ejmech.2018.11.070
None Unchecked Ratio IC50 92.5 None 10.1016/j.ejmech.2021.113316
None Unchecked Ratio IC50 101.6 None 10.1016/j.ejmech.2018.11.070
None Unchecked Ratio IC50 103.5 None 10.1021/acs.jmedchem.8b00827
None Unchecked Ratio IC50 103.5 None 10.1021/acs.jmedchem.9b00706
None Unchecked Ratio IC50 118.0 None 10.1021/acs.jmedchem.2c01208
None Unchecked Ratio IC50 120.0 None 10.1021/acs.jmedchem.1c00404
None Unchecked Ratio IC50 139.9 None 10.1021/acs.jmedchem.2c01595
None Unchecked Ratio IC50 140.0 None 10.1021/acs.jmedchem.1c00404
None Unchecked Ratio IC50 150.0 None 10.1016/j.bmcl.2021.127923
None Unchecked Ratio IC50 151.7 None 10.1021/acs.jmedchem.9b01815
None Unchecked Ratio IC50 158.6 None 10.1016/j.ejmech.2017.03.031
None Unchecked Ratio IC50 167.0 None 10.1016/j.ejmech.2020.112323
None Unchecked Ratio IC50 190.0 None 10.1021/acs.jmedchem.2c01208
None Unchecked Ratio IC50 195.0 None 10.1016/j.ejmech.2018.11.004
None Unchecked Ratio IC50 200.0 None 10.1021/acs.jmedchem.1c00404
None Unchecked Ratio IC50 210.0 None 10.1021/acs.jmedchem.1c00404
None Unchecked Ratio IC50 212.12 None 10.1016/j.ejmech.2018.11.004
None Unchecked Ratio IC50 214.0 None 10.1016/j.ejmech.2019.111584
None Unchecked Ratio IC50 240.0 None 10.1016/j.bmc.2018.09.025
None Unchecked Ratio IC50 240.0 None 10.1016/j.bmc.2021.116061
None Unchecked Ratio IC50 240.0 None 10.1016/j.bmc.2023.117217
None Unchecked Ratio IC50 240.0 None 10.1016/j.bmcl.2018.07.039
None Unchecked Ratio IC50 250.0 None 10.1016/j.ejmech.2022.114112
None Unchecked Ratio IC50 283.6 None 10.1021/acs.jmedchem.6b00158
None Unchecked Ratio IC50 289.0 None 10.1021/acs.jmedchem.1c02159
None Unchecked Ratio IC50 388.3 None 10.1016/j.ejmech.2018.07.029
None Unchecked Ratio IC50 421.8 None 10.1021/acs.jmedchem.0c01837
None Unchecked Ratio IC50 445.0 None 10.1016/j.ejmech.2018.02.062
None Unchecked Ratio IC50 500.0 None 10.1016/j.bmc.2016.11.026
None Unchecked Ratio IC50 500.0 None 10.1016/j.ejmech.2018.02.045
None Unchecked Ratio IC50 567.4 None 10.1016/j.ejmech.2017.07.040
None Unchecked Ratio IC50 609.0 None 10.1021/acs.jmedchem.1c01451
None Unchecked Ratio IC50 662.3 None 10.1021/acs.jmedchem.9b01815
None Unchecked Ratio IC50 696.1 None 10.1016/j.ejmech.2022.114372
None Unchecked Ratio IC50 759.0 None 10.1016/j.ejmech.2017.06.001
None Unchecked Ratio IC50 776.0 None 10.1016/j.bmc.2017.04.012
None Unchecked Ratio IC50 805.0 None 10.1016/j.bmc.2008.11.016
None Unchecked Ratio IC50 822.0 None 10.1016/j.bmcl.2007.03.070
None Unchecked Ratio IC50 822.0 None 10.1021/jm060717i
None Unchecked Ratio IC50 864.0 None 10.1016/j.bmc.2018.04.010
None Unchecked Ratio IC50 864.0 None 10.1016/j.bmc.2020.115887
None Unchecked Ratio IC50 864.0 None 10.1021/jm400639z
None Unchecked Ratio IC50 869.0 None 10.1021/acs.jmedchem.9b00706
None Unchecked Ratio IC50 936.0 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio IC50 964.0 None 10.1016/j.ejmech.2022.114466
None Unchecked Ratio IC50 964.0 None 10.1021/acs.jmedchem.6b00158
None Unchecked Ratio IC50 974.4 None 10.1021/acs.jmedchem.1c02159
None Unchecked Ratio IC50 975.0 None 10.1016/j.bmcl.2005.08.066
None Unchecked Ratio IC50 978.0 None 10.1021/acs.jmedchem.1c01451
None Unchecked Ratio IC50 1000.0 None 10.1021/acs.jmedchem.7b01858
None Unchecked Ratio IC50 1197.0 None 10.1021/acs.jnatprod.7b00857
None Unchecked Ratio IC50 1418.0 None 10.1016/j.bmcl.2018.11.023
None Unchecked Ratio IC50 2042.3 None 10.1016/j.ejmech.2017.07.040
None Unchecked Ratio IC50 3110.0 None 10.1016/j.bmc.2014.05.048
None Unchecked Ratio IC50 3852.53 None 10.1016/j.ejmech.2018.05.003
None Unchecked Ratio IC50 5157.0 None 10.1016/j.ejmech.2017.06.001
None Unchecked Ratio IC50 5416.0 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio IC50 5521.0 None 10.1021/acs.jnatprod.7b01047
None Unchecked Ratio IC50 100000.0 None 10.1016/j.ejmech.2018.07.029
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2018.11.023
None Unchecked Ratio IC50 nan None 10.1016/j.ejmech.2018.11.070
None Unchecked Relative effect 1.0 None 10.1021/jm00079a019
None Unchecked Relative initial slope 100.0 None 10.1021/jm00036a009
None Unchecked Selectivity Index 0.89 None 10.1016/j.bmc.2021.116442
None Unchecked Selectivity Index 1.2 None 10.1016/j.bmcl.2019.08.019
None Unchecked Selectivity Index 1.29 None 10.1016/j.bmcl.2019.08.019
None Unchecked Selectivity Index 2325.6 None 10.1039/C5MD00057B
None Unchecked Selectivity ratio 1.0 None 10.1016/j.bmcl.2019.06.035
None Unchecked Selectivity ratio nan None 10.1016/j.ejmech.2019.112022
None Unchecked Survival 98.66 % 10.1016/j.ejmech.2022.114207
None Unchecked TGI 28.6 % 10.1021/acs.jmedchem.2c01595
None Unchecked TGI 30.0 % 10.1021/acs.jmedchem.1c01451
None Unchecked TGI 37.8 % 10.1021/acs.jmedchem.9b00706
None Unchecked TIME 0.01833 hr 10.1021/acs.jnatprod.1c00211
None Unchecked VCR accumulation 50.0 None 10.1016/s0960-894x(98)00262-5
None Unchecked VCR accumulation 93.0 None 10.1016/s0960-894x(98)00262-5
None Unchecked Vmax 21.0 milli optical density/minute 10.1021/acs.jmedchem.6b01264
None Unchecked Vmax 63.3 milli optical density/minute 10.1016/j.ejmech.2020.112176
None Unchecked Vmax 76.0 milli optical density/minute 10.1021/acs.jmedchem.8b00986

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT004310 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C.CC(=O)[CoA]>>CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C enzymemap_29110
AKRT004311 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C.CC(=O)[32S]>>CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C None
AKRT004326 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](N)c3ccccc3)C(C)=C1C2(C)C.O=C([CoA])c1ccccc1>>CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C RXN-8859
AKRT004327 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)[C@H](O)[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C>>CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C MNXR102275