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Baraphenazine E

AlkaPlorer ID: AK008270

Synonym: None

IUPAC Name: (1S,16S,28S)-20,28-dihydroxy-4,11,18,25-tetrazaheptacyclo[14.11.1.02,15.03,12.05,10.017,26.019,24]octacosa-2(15),3,5,7,9,11,13,17,19(24),20,22,25-dodecaene-9-carboxamide

Structure

SMILES: N=C(O)C1=CC=CC2=NC3=C4C(=CC=C3N=C12)[C@H]1C2=NC3=C(O)C=CC=C3N=C2C[C@@H]4[C@@H]1O

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InChI: InChI=1S/C25H17N5O3/c26-25(33)11-3-1-4-13-20(11)28-15-8-7-10-18(22(15)29-13)12-9-16-23(19(10)24(12)32)30-21-14(27-16)5-2-6-17(21)31/h1-8,12,19,24,31-32H,9H2,(H2,26,33)/t12-,19-,24-/m0/s1

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InChIKey: GXPOPLPOQDCTPY-JGWMJADOSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Streptomyces sp. Streptomyces Streptomycetaceae Kitasatosporales Actinomycetes Actinomycetota None Bacteria

Properties Information

Molecule Weight: 435.44300000000015

TPSA？: 136.1

MolLogP？: 3.461270000000002

Number of H-Donors: 4

Number of H-Acceptors: 7

RingCount: 7

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Ambystoma mexicanum Ambystoma mexicanum Activity nan None 10.1021/acs.jnatprod.9b00289
Bacillus subtilis Bacillus subtilis MIC 7500.0 nM 10.1021/acs.jnatprod.9b00289
Escherichia coli Escherichia coli MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Homo sapiens A549 IC50 2400.0 nM 10.1021/acs.jnatprod.9b00289
Homo sapiens PC-3 IC50 4700.0 nM 10.1021/acs.jnatprod.9b00289
Micrococcus luteus Micrococcus luteus MIC 7500.0 nM 10.1021/acs.jnatprod.9b00289
Mycolicibacterium aurum Mycolicibacterium aurum MIC 30000.0 nM 10.1021/acs.jnatprod.9b00289
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Salmonella enterica Salmonella enterica MIC 120000.0 nM 10.1021/acs.jnatprod.9b00289
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1021/acs.jnatprod.9b00289

Metabolism Information