UK-2C
AlkaPlorer ID: AK008530
Synonym: 'Antibiotic UK 2C', 'UK-2C', 'UK 2C'
IUPAC Name: [(3S,6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxypyridine-2-carbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
Structure
SMILES: COC1=CC=NC(C(=O)N[C@H]2COC(=O)[C@H](CC3=CC=CC=C3)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)=C1O
InChI: InChI=1S/C27H32N2O9/c1-15(2)12-21(30)38-24-16(3)37-27(34)19(29-25(32)22-23(31)20(35-4)10-11-28-22)14-36-26(33)18(24)13-17-8-6-5-7-9-17/h5-11,15-16,18-19,24,31H,12-14H2,1-4H3,(H,29,32)/t16-,18+,19-,24-/m0/s1
InChIKey: ISHRABPLRWRZQX-DOGKRZLPSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | None | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 528.5580000000003
TPSA？: 150.35000000000002
MolLogP？: 2.1995
Number of H-Donors: 2
Number of H-Acceptors: 10
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Rattus norvegicus | RBL-2H3 | Activity | nan | None | 10.1021/acs.jnatprod.8b00559 |
| Rattus norvegicus | RBL-2H3 | IC50 | 4386.0 | nM | 10.1021/acs.jnatprod.8b00559 |