Histidinol
AlkaPlorer ID: AK008597
Synonym: None
IUPAC Name: (2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-ol
Structure
SMILES: N[C@H](CO)CC1=CN=CN1
InChI: InChI=1S/C6H11N3O/c7-5(3-10)1-6-2-8-4-9-6/h2,4-5,10H,1,3,7H2,(H,8,9)/t5-/m0/s1
InChIKey: ZQISRDCJNBUVMM-YFKPBYRVSA-N
Reference
L-HISTIDINOL, A PRECURSOR OF L-HISTIDINE IN Escherichia coli
PubChem CID: 165271
CAS: 4836-52-6
LOTUS: LTS0157382
NPASS: NPC320526
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Homo sapiens | Homo | Hominidae | Primates | Mammalia | Chordata | Metazoa | Eukaryota |
| Saccharomyces cerevisiae | Saccharomyces | Saccharomycetaceae | Saccharomycetales | Saccharomycetes | Ascomycota | Fungi | Eukaryota |
| Escherichia coli | Escherichia | Enterobacteriaceae | Enterobacterales | Gammaproteobacteria | Pseudomonadota | None | Bacteria |
Properties Information
Molecule Weight: 141.174
TPSA？: 74.93
MolLogP？: -0.7282000000000004
Number of H-Donors: 3
Number of H-Acceptors: 3
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Brucella suis biovar 1 (strain 1330) | Histidinol dehydrogenase | Km | 12000.0 | nM | 10.1016/j.bmc.2007.04.027 |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 44668.4 | nM | None |
| Homo sapiens | Olfactory receptor 51E2 | EC50 | 0.035 | nM | None |
| Homo sapiens | Olfactory receptor 51E2 | Ratio | 0.578 | None | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 35481.3 | nM | None |
| Rattus norvegicus | Histamine H3 receptor | Ki | 3981071705534969.5 | nM | 10.1021/jm980408v |