Hydrocarbostyril
AlkaPlorer ID: AK008654
Synonym: None
IUPAC Name: 3,4-dihydro-1H-quinolin-2-one
Structure
SMILES: C1CC(=O)NC2=CC=CC=C21
InChI: InChI=1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)
InChIKey: TZOYXRMEFDYWDQ-UHFFFAOYSA-N
Reference
3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp. LGE21
PubChem CID: 64796
CAS: 553-03-7
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | Bacillati | Bacteria |
Properties Information
Molecule Weight: 147.17699999999996
TPSA？: 29.1
MolLogP？: 1.5713
Number of H-Donors: 1
Number of H-Acceptors: 1
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | DNA polymerase iota | Potency | 89125.1 | nM | None |
| Homo sapiens | Glucagon-like peptide 1 receptor | Potency | 12589.3 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 50118.7 | nM | None |
| Homo sapiens | Histone acetyltransferase GCN5 | Potency | 15848.9 | nM | None |
| Homo sapiens | MAP kinase p38 | IC50 | 0.74 | nM | 10.1021/jm061061w |
| Homo sapiens | MAP kinase p38 alpha | IC50 | 0.74 | nM | 10.1016/j.bmc.2010.01.070 |
| Homo sapiens | Niemann-Pick C1 protein | Potency | 1000.0 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 14715.7 | nM | None |
| None | Unchecked | Activity | 90.0 | % | None |
| None | Unchecked | IC20 | nan | None | None |
| None | Unchecked | IC50 | nan | None | None |
| None | Unchecked | Potency | 7079.5 | nM | None |