(+)-Norephedrine
AlkaPlorer ID: AK008659
Synonym: 'Norephedrine', '', 'pseudonorephedrine', 'Mucorama', 'DL-Phenylpropanolamine', 'L-Phenyl Propanolamine', 'd-Norephedrine', 'Obestat', '(+)-Norephedrine', 'norpseudoephedrine', '(+)-Norpseudoephedrine', 'Prestwick_388', 'Propadrine', 'Nobese', 'Cathine', 'Hydriatine', 'L-NOREPHEDRINE', 'D-Cathine', 'DL-Norephedrine'
IUPAC Name: [(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]azanium
Structure
SMILES: C[C@@H]([NH3+])[C@@H](O)C1=CC=CC=C1
InChI: InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/p+1/t7-,9-/m1/s1
InChIKey: DLNKOYKMWOXYQA-VXNVDRBHSA-O
Source
Properties Information
Molecule Weight: 152.21699999999998
TPSA？: 47.870000000000005
MolLogP？: 0.3503999999999995
Number of H-Donors: 2
Number of H-Acceptors: 1
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bos taurus | Phenylethanolamine N-methyltransferase | Ki | 2980000.0 | nM | 10.1021/jm00118a021 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | -5.79 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | 0.41 | % | 10.6019/CHEMBL4808148 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | IC50 | 19952.62 | nM | 10.6019/CHEMBL4651402 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | IC50 | 20000.0 | nM | 10.6019/CHEMBL4651402 |
| None | No relevant target | pKa | 9.05 | None | 10.1007/s11095-013-1232-z |