1-Phenazinecarboxylic acid
AlkaPlorer ID: AK008770
Synonym: '2538-68-3', 'Phenazine-1-carboxylic acid', 'SMR000386925', 'MLS000777209', 'MLSMR', 'Tubermycin B, sodium salt', 'MLS001049089', '1-Phenazinecarboxylic acid', 'tubermycin B'
IUPAC Name: phenazine-1-carboxylic acid
Structure
SMILES: O=C(O)C1=CC=CC2=NC3=CC=CC=C3N=C12
InChI: InChI=1S/C13H8N2O2/c16-13(17)8-4-3-7-11-12(8)15-10-6-2-1-5-9(10)14-11/h1-7H,(H,16,17)
InChIKey: JGCSKOVQDXEQHI-UHFFFAOYSA-N
Reference
A study of the biosynthesis of phenazine-1-carboxylic acid
PubChem CID: 95069
CAS: 102646-59-3
LOTUS: LTS0104136
SuperNatural Ⅲ: SN0164558
COCONUT: CNP0254586
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces antibioticus | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 224.219
TPSA？: 63.08
MolLogP？: 2.4812000000000003
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Alternaria solani | Alternaria solani | EC50 | 18.5 | ug.mL-1 | 10.1021/jf904408c |
| Alternaria solani | Alternaria solani | Inhibition | 100.0 | % | 10.1021/jf904408c |
| Bacillus cereus | Bacillus cereus | MIC | 0.5 | ug.mL-1 | 10.1021/np960095b |
| Bacillus subtilis | Bacillus subtilis | GI | nan | None | 10.1039/C2MD20045G |
| Bacillus subtilis | Bacillus subtilis | IC50 | 150000.0 | nM | 10.1021/np2009626 |
| Botryosphaeria berengeriana | Botryosphaeria berengeriana | EC50 | 3.58 | ug.mL-1 | 10.1021/jf904408c |
| Botryosphaeria berengeriana | Botryosphaeria berengeriana | Inhibition | 100.0 | % | 10.1021/jf904408c |
| Escherichia coli | Escherichia coli | GI | nan | None | 10.1039/C2MD20045G |
| Fusarium graminearum | Fusarium graminearum | EC50 | 50.0 | ug.mL-1 | 10.1021/jf904408c |
| Fusarium graminearum | Fusarium graminearum | Inhibition | 43.1 | % | 10.1021/jf904408c |
| Fusarium oxysporum | Fusarium oxysporum | EC50 | 14.9 | ug.mL-1 | 10.1021/jf904408c |
| Fusarium oxysporum | Fusarium oxysporum | Inhibition | 65.4 | % | 10.1021/jf904408c |
| Homo sapiens | Acetylcholinesterase | IC50 | 50000.0 | nM | 10.1021/np2009626 |
| Homo sapiens | Aldehyde dehydrogenase 1A1 | Potency | 28183.8 | nM | None |
| Homo sapiens | Alpha-synuclein | Potency | 35481.3 | nM | None |
| Homo sapiens | ATPase family AAA domain-containing protein 5 | Potency | 23099.9 | nM | None |
| Homo sapiens | Chromobox protein homolog 1 | Potency | 100000.0 | nM | None |
| Homo sapiens | DNA-(apurinic or apyrimidinic site) lyase | Potency | 31622.8 | nM | None |
| Homo sapiens | Eyes absent homolog 2 | Potency | 100000.0 | nM | None |
| Homo sapiens | Geminin | Potency | 8199.5 | nM | None |
| Homo sapiens | HCT-116 | IC50 | 15600.0 | nM | 10.1021/np3005166 |
| Homo sapiens | HepG2 | Potency | 35481.3 | nM | None |
| Homo sapiens | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Potency | 39810.7 | nM | None |
| Homo sapiens | LNCaP | IZ | nan | None | 10.1021/np3005166 |
| Homo sapiens | MCF7 | IZ | nan | None | 10.1021/np3005166 |
| Homo sapiens | Mothers against decapentaplegic homolog 3 | Potency | 11220.2 | nM | None |
| Homo sapiens | Muscleblind-like protein 1 | Potency | 10000.0 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 2310.9 | nM | None |
| Homo sapiens | Nuclear factor erythroid 2-related factor 2 | Potency | 3264.3 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 23109.3 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 29092.9 | nM | None |
| Human immunodeficiency virus 1 | Aberrant vpr protein | Potency | 3162.3 | nM | None |
| Influenza A virus | Nonstructural protein 1 | Potency | 1258.9 | nM | None |
| Micrococcus luteus | Micrococcus luteus | MIC | 5.0 | ug.mL-1 | 10.1021/np960095b |
| Mycobacterium tuberculosis | Mycobacterium tuberculosis | MIC90 | 32.9 | ug.mL-1 | 10.1021/np3005166 |
| Mycolicibacterium aurum | Mycolicibacterium aurum | MIC | 50.0 | ug.mL-1 | 10.1021/np400915p |
| Mycolicibacterium fortuitum | Mycolicibacterium fortuitum | MIC | 50.0 | ug.mL-1 | 10.1021/np400915p |
| Mycolicibacterium smegmatis | Mycolicibacterium smegmatis | MIC | 50.0 | ug.mL-1 | 10.1021/np400915p |
| Mycolicibacterium vaccae | Mycolicibacterium vaccae | Activity | nan | None | 10.1021/np400915p |
| Mycolicibacterium vaccae | Mycolicibacterium vaccae | MIC | 25.0 | ug.mL-1 | 10.1021/np400915p |
| Mycosphaerella arachidis | Mycosphaerella arachidis | EC50 | 13.2 | ug.mL-1 | 10.1021/jf904408c |
| Mycosphaerella arachidis | Mycosphaerella arachidis | Inhibition | 92.3 | % | 10.1021/jf904408c |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 329.4 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 26168.7 | nM | None |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 5.0 | ug.mL-1 | 10.1021/np960095b |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 64.0 | ug.mL-1 | 10.1016/j.ejmech.2016.09.079 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 100.0 | ug.mL-1 | 10.1021/np400915p |
| Streptomyces coelicolor | Streptomyces coelicolor | GI | nan | None | 10.1039/C2MD20045G |
| None | ADMET | IC50 | 50000.0 | nM | 10.1021/np2009626 |
| None | Molecular identity unknown | IZ | 2.0 | mm | 10.1021/np3005166 |
| None | NON-PROTEIN TARGET | IZ | nan | None | 10.1021/np3005166 |
| None | Unchecked | EC50 | 47641.0 | nM | None |
| None | Unchecked | Potency | 5623.4 | nM | None |