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name Structure Reference Source Properties Activities Metabolism

4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide

AlkaPlorer ID: AK009038

Synonym: None

IUPAC Name: 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide

Structure

SMILES: N=C(N)C1=CC=C(OCCCCCOC2=CC=C(C(=N)N)C=C2)C=C1

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InChI: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)

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InChIKey: XDRYMKDFEDOLFX-UHFFFAOYSA-N

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Reference

PubChem CID: 4735

CAS: 100-33-4

NPASS: NPC53494

COCONUT: CNP0340014

Properties Information

Molecule Weight: 340.427

TPSA？: 118.2

MolLogP？: 2.8828400000000007

Number of H-Donors: 4

Number of H-Acceptors: 4

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Survival 90.0 % 10.1016/j.bmcl.2022.129113
Acinetobacter baumannii Acinetobacter baumannii Survival 100.0 % 10.1016/j.bmcl.2022.129113
Aspergillus fumigatus Aspergillus fumigatus Activity nan None 10.1016/j.bmc.2006.10.006
Bos taurus Calf thymus DNA Delta Tm 10.7 None 10.1021/jm00081a003
Bos taurus Calf thymus DNA Delta Tm 11.1 degrees C 10.1021/jm030545e
Bos taurus Calf thymus DNA DNA binding 11.1 degrees C 10.1021/jm020375q
Bos taurus Calf thymus DNA Tm 10.7 degrees C 10.1021/jm00064a008
Bos taurus DNA Delta Tm 10.6 degrees C 10.1021/jm301614w
Bos taurus DNA Delta Tm 10.7 degrees C 10.1021/jm301358s
Bos taurus DNA Delta Tm 11.6 degrees C 10.1007/s00044-005-0130-2
Bos taurus DNA Delta Tm 20.6 degrees C 10.1021/jm301614w
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans GI nan None 10.1039/C2MD20143G
Candida albicans Candida albicans IC50 0.19 ug.mL-1 10.1016/j.bmc.2015.07.006
Candida albicans Candida albicans IC50 12.2 ug.mL-1 10.1016/j.bmc.2015.07.006
Candida albicans Candida albicans IC50 25.0 ug.mL-1 10.1016/j.bmc.2015.07.006
Candida albicans Candida albicans IC50 nan None 10.1016/j.bmc.2006.10.006
Candida albicans Candida albicans MIC 25.0 ug.mL-1 10.1016/j.bmc.2015.07.006
Candida parapsilosis Candida parapsilosis MIC 12.5 ug.mL-1 10.1016/j.bmc.2015.07.006
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus sabaeus Vero Activity nan None 10.1021/np020592u
Chlorocebus sabaeus Vero Activity nan None 10.1021/np030045o
Chlorocebus sabaeus Vero Activity nan None 10.1021/np0400095
Chlorocebus sabaeus Vero CC50 47000.0 nM 10.1016/j.bmc.2014.01.029
Chlorocebus sabaeus Vero CC50 47000.0 nM 10.1016/j.bmcl.2011.02.100
Chlorocebus sabaeus Vero CC50 47000.0 nM 10.1016/j.bmcl.2017.05.071
Chlorocebus sabaeus Vero CC50 85860.0 nM 10.1021/ml400317e
Chlorocebus sabaeus Vero IC50 50.0 ug.mL-1 10.1021/np049682k
Chlorocebus sabaeus Vero IC50 13700.0 nM 10.1021/np0702281
Chlorocebus sabaeus Vero IC50 57000.0 nM 10.1016/j.ejmech.2013.04.066
Chlorocebus sabaeus Vero IC50 100000.0 nM 10.1016/j.bmcl.2008.03.020
Chlorocebus sabaeus Vero IC50 nan None 10.1007/s00044-011-9798-7
Chlorocebus sabaeus Vero IC50 nan None 10.1016/j.bmc.2006.10.006
Chlorocebus sabaeus Vero IC50 nan None 10.1016/j.bmc.2006.10.062
Chlorocebus sabaeus Vero IC50 nan None 10.1016/j.bmc.2007.06.042
Chlorocebus sabaeus Vero IC50 nan None 10.1016/j.bmc.2009.10.042
Chlorocebus sabaeus Vero IC50 nan None 10.1021/jm100507q
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np030086k
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np030524n
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np0502600
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np0601399
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np2004825
Chlorocebus sabaeus Vero IC50 nan None 10.1021/np800653z
Chlorocebus sabaeus Vero IC50 nan None 10.1039/C3MD00097D
Chlorocebus sabaeus Vero TC50 nan None 10.1021/np800163u
Chlorocebus sabaeus Vero TC50 nan None 10.1039/C2MD20143G
Cryptococcus neoformans Cryptococcus neoformans IC50 nan None 10.1016/j.bmc.2006.10.006
Cryptococcus neoformans Cryptococcus neoformans IC50 nan None 10.1039/C2MD20143G
Cryptococcus neoformans Cryptococcus neoformans MIC 100.0 ug.mL-1 10.1016/j.bmc.2015.07.006
Cryptosporidium parvum Cryptosporidium parvum Of control 20.8 % 10.1021/jm9604484
Entamoeba histolytica Entamoeba histolytica IC50 11800.0 nM 10.1016/j.bmcl.2011.02.100
Entamoeba histolytica Entamoeba histolytica IC50 11801.0 nM 10.1016/j.bmcl.2008.05.009
Entamoeba histolytica Entamoeba histolytica IC50 nan None 10.1016/j.ejmech.2010.03.050
Escherichia coli Escherichia coli EC50 12000.0 nM 10.1021/jm501449u
Escherichia coli Escherichia coli MIC 100.0 ug.mL-1 10.1021/acs.jmedchem.7b00204
Escherichia coli GroEL/GroES IC50 100000.0 nM 10.1016/j.bmcl.2016.09.051
Escherichia coli GroEL/GroES IC50 250000.0 nM 10.1016/j.bmcl.2016.09.051
Giardia intestinalis Giardia intestinalis IC50 4079.0 nM 10.1016/j.bmc.2014.01.029
Giardia intestinalis Giardia intestinalis IC50 4079.0 nM 10.1016/j.bmcl.2008.05.009
Giardia intestinalis Giardia intestinalis IC50 4079.0 nM 10.1016/j.bmcl.2011.02.100
Giardia intestinalis Giardia intestinalis IC50 4079.0 nM 10.1016/j.bmcl.2017.05.071
Giardia intestinalis Giardia intestinalis IC50 nan None 10.1016/j.ejmech.2010.03.050
Homo sapiens 786-0 GI50 13708.82 nM None
Homo sapiens 786-0 IC50 25000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens 786-0 IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens A549 Activity nan None 10.1016/j.ejmech.2016.12.017
Homo sapiens A549 GI50 10990.06 nM None
Homo sapiens A549 GI50 25000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens A549 GI50 100000.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens A549 IC50 40.0 nM 10.1021/jm030545e
Homo sapiens A549 IC50 23500.0 nM 10.1039/C7MD00445A
Homo sapiens A549 IC50 24000.0 nM 10.1016/j.bmcl.2004.06.034
Homo sapiens A549 IC50 24000.0 nM 10.1016/j.bmcl.2009.08.073
Homo sapiens A549 IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Acetylcholinesterase AC50 7280.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN GI50 23604.78 nM None
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 16426.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 4077.1 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 1375.0 nM None
Homo sapiens Alpha-2a adrenergic receptor Ki 516.0 nM None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile acid receptor FXR Activity 9.2 % 10.1016/j.bmc.2014.02.049
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 1000000.0 nM 10.1124/dmd.112.047068
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens BT-549 GI50 11117.32 nM None
Homo sapiens CAKI-1 GI50 57016.43 nM None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Calu-3 CC50 450000.0 nM 10.1021/acsmedchemlett.3c00035
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin B Inhibition nan % 10.1021/jm900629w
Homo sapiens Cathepsin B Ki nan None 10.1021/jm900629w
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCRF-CEM GI50 45081.67 nM None
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Coagulation factor X IC50 10400.0 nM 10.1021/acs.jmedchem.9b01060
Homo sapiens COLO 205 GI50 11912.42 nM None
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 25000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens Cytochrome P450 1A2 IC50 100000.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 1A2 IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 25000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens Cytochrome P450 2C19 IC50 100000.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 2C19 IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 25000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens Cytochrome P450 2C9 IC50 100000.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 2C9 IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 10000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens Cytochrome P450 2D6 IC50 24800.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 2D6 IC50 24800.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 25000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens Cytochrome P450 3A4 IC50 100000.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 3A4 IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1016/j.ejmech.2016.12.017
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Diamine oxidase Ki 290.0 nM 10.1016/j.bmc.2014.02.049
Homo sapiens Dopamine D1 receptor AC50 9801.4 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 3998.0 nM None
Homo sapiens Dopamine D3 receptor Ki 1358.0 nM None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 2395.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 3159.0 nM None
Homo sapiens Dopamine transporter Ki 2510.0 nM None
Homo sapiens DU-145 GI50 13212.96 nM None
Homo sapiens EKVX GI50 19098.53 nM None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Ferrochelatase, mitochondrial Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A IC50 720.0 nM 10.1016/j.bmc.2014.02.049
Homo sapiens Glyceraldehyde-3-phosphate dehydrogenase liver IC50 50000.0 nM 10.1021/jm000472o
Homo sapiens HCC 2998 GI50 12246.16 nM None
Homo sapiens HCT-116 GI50 22438.82 nM None
Homo sapiens HCT-15 GI50 24774.22 nM None
Homo sapiens HEK293 CC50 670.0 nM 10.1039/d0md00058b
Homo sapiens HEK293 CC50 4000.0 nM 10.1016/j.bmcl.2023.129123
Homo sapiens HEK293 IC50 71000.0 nM 10.1016/j.bmc.2011.06.006
Homo sapiens HEK293 Inhibition 58.3 % 10.1016/j.bmcl.2010.05.091
Homo sapiens HEK-293T CC50 nan None 10.1021/acs.jmedchem.6b01740
Homo sapiens HeLa IC50 15000.0 nM 10.1016/j.ejmech.2012.10.048
Homo sapiens HepG2 CC50 2300.0 nM 10.1016/j.bmc.2013.09.002
Homo sapiens HepG2 CC50 2300.0 nM 10.1016/j.bmc.2015.03.064
Homo sapiens HepG2 CC50 2300.0 nM 10.1016/j.ejmech.2012.04.029
Homo sapiens HepG2 CC50 2300.0 nM 10.1016/j.ejmech.2014.05.037
Homo sapiens HepG2 CC50 2300.0 nM 10.1016/j.ejmech.2014.12.056
Homo sapiens HepG2 CC50 2300.0 nM 10.1021/acsmedchemlett.8b00347
Homo sapiens HepG2 IC50 159710.0 nM 10.1016/j.bmcl.2014.02.046
Homo sapiens HepG2 IC50 nan None 10.1039/C3MD00097D
Homo sapiens HERG AC50 4600.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 10000.0 nM 10.1021/acs.jmedchem.8b02021
Homo sapiens HERG IC50 15721.5 nM None
Homo sapiens HERG IC50 18700.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens HERG IC50 18800.0 nM 10.1016/j.ejmech.2016.12.017
Homo sapiens HERG Inhibition nan % 10.1016/j.ejmech.2016.12.017
Homo sapiens HERG Ki 12880.2 nM None
Homo sapiens HFF CC50 nan None 10.1021/acs.jmedchem.6b01740
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 643.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase IC50 nan None 10.1016/j.bmc.2009.10.042
Homo sapiens Histone deacetylase 6 Inhibition -380.39 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -16.46 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 GI50 19319.68 nM None
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Cmax 900.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 3.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens T1/2 265.0 hr 10.1016/j.bmc.2014.12.066
Homo sapiens HOP-62 GI50 14927.94 nM None
Homo sapiens HOP-92 GI50 28510.18 nM None
Homo sapiens Hs-578T GI50 14927.94 nM None
Homo sapiens HSP60/HSP10 IC50 100000.0 nM 10.1016/j.bmcl.2016.09.051
Homo sapiens HSP60/HSP10 IC50 250000.0 nM 10.1016/j.bmcl.2016.09.051
Homo sapiens HT-29 GI50 35481.34 nM None
Homo sapiens Huh-7 CC50 6250.0 nM 10.1073/pnas.0802982105
Homo sapiens IGROV-1 GI50 35481.34 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens K562 GI50 3451.44 nM None
Homo sapiens K562 IC50 nan None 10.1021/np100201p
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KB CC50 52700.0 nM 10.1016/j.bmcl.2012.10.101
Homo sapiens KB IC50 0.11 ug.mL-1 10.1021/np010419i
Homo sapiens KM12 GI50 14256.08 nM None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens LOX IMVI GI50 16143.59 nM None
Homo sapiens M14 GI50 15523.87 nM None
Homo sapiens Macrophage CC50 10000.0 nM 10.1021/acs.jmedchem.2c00232
Homo sapiens Malme-3M IC50 10200.0 nM 10.1021/ml300166s
Homo sapiens Malme-3M IC50 12200.0 nM 10.1021/ml300166s
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matriptase Ki 1160.0 nM 10.1021/jm000395x
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 GI50 9549.93 nM None
Homo sapiens MDA-MB-231 GI50 16710.91 nM None
Homo sapiens MDA-MB-435 GI50 16634.13 nM None
Homo sapiens MDA-N GI50 15595.53 nM None
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MOLT-4 GI50 28313.92 nM None
Homo sapiens Monoamine oxidase A AC50 1792.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 793.0 nM None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MRC5 IC50 5.7 ug.mL-1 10.1016/j.bmcl.2013.12.052
Homo sapiens MRC5 IC50 5.71 ug.mL-1 10.1016/j.bmc.2008.10.061
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 410.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 2000.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 2700.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 IC50 2700.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 IC50 10400.0 nM 10.1021/jm301302s
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 2102.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 1581.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 1425.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki 507.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 1580.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki 220.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 2885.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki 2073.0 nM None
Homo sapiens NCI/ADR-RES GI50 71614.34 nM None
Homo sapiens NCI-H226 GI50 14223.29 nM None
Homo sapiens NCI-H23 GI50 10351.42 nM None
Homo sapiens NCI-H322M GI50 46773.51 nM None
Homo sapiens NCI-H460 GI50 2978.52 nM None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Norepinephrine transporter AC50 1325.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 2214.0 nM None
Homo sapiens Norepinephrine transporter Ki 2196.0 nM None
Homo sapiens OVCAR-3 GI50 14288.94 nM None
Homo sapiens OVCAR-4 GI50 10914.4 nM None
Homo sapiens OVCAR-5 GI50 21037.78 nM None
Homo sapiens OVCAR-8 GI50 13708.82 nM None
Homo sapiens PC-3 GI50 18492.69 nM None
Homo sapiens PC-3 IC50 nan nM 10.1021/jm0304461
Homo sapiens PC-3 IC50 nan None 10.1021/np0502600
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasminogen IC50 3600.0 nM 10.1021/acs.jmedchem.9b01060
Homo sapiens Plasminogen IC50 8400.0 nM 10.1021/acs.jmedchem.9b01060
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Porphobilinogen deaminase Inhibition nan % 10.6019/CHEMBL3987221
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein-arginine N-methyltransferase 1 IC50 81000.0 nM 10.1021/acs.jmedchem.1c01208
Homo sapiens Protein-arginine N-methyltransferase 1 IC50 81000.0 nM 10.1039/C6MD00573J
Homo sapiens Protein-arginine N-methyltransferase 1 Inhibition nan % 10.1039/C6MD00573J
Homo sapiens Protein arginine N-methyltransferase 5 IC50 582000.0 nM 10.1039/C6MD00573J
Homo sapiens Protein arginine N-methyltransferase 5 Inhibition nan % 10.1039/C6MD00573J
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein-tyrosine phosphatase 4A3 IC50 300.0 nM 10.1016/j.bmcl.2019.06.048
Homo sapiens Protein-tyrosine phosphatase 4A3 IC50 53600.0 nM 10.1016/j.bmcl.2006.02.060
Homo sapiens Protein-tyrosine phosphatase 4A3 IC50 53600.0 nM 10.1016/j.bmcl.2008.03.013
Homo sapiens Protein tyrosine phosphatase type IVA 1 IC50 300.0 nM 10.1016/j.bmcl.2019.06.048
Homo sapiens Protein tyrosine phosphatase type IVA 2 IC50 300.0 nM 10.1016/j.bmcl.2019.06.048
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens RPMI-8226 GI50 6870.68 nM None
Homo sapiens RXF 393 GI50 16749.43 nM None
Homo sapiens S-100 protein beta chain IC50 100000.0 nM 10.1016/j.bmc.2012.12.042
Homo sapiens S-100 protein beta chain Inhibition 14.2 % 10.1016/j.bmc.2012.12.042
Homo sapiens S-100 protein beta chain Kd 1000.0 nM 10.1021/jm0497038
Homo sapiens Serine/threonine-protein kinase Aurora-B IC50 100000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 1639.0 nM None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 468.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 3278.0 nM None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki 1717.0 nM None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter AC50 8108.3 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens SF-268 GI50 17179.08 nM None
Homo sapiens SF-295 GI50 11402.5 nM None
Homo sapiens SF-539 GI50 12647.36 nM None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SK-MEL-2 GI50 9057.33 nM None
Homo sapiens SK-MEL-28 GI50 14655.48 nM None
Homo sapiens SK-MEL-5 GI50 10069.32 nM None
Homo sapiens SK-OV-3 GI50 1224.62 nM None
Homo sapiens SN12C GI50 6546.36 nM None
Homo sapiens SNB-19 GI50 10715.19 nM None
Homo sapiens SNB-75 GI50 100000.0 nM None
Homo sapiens Solute carrier family 22 member 1 IC50 22100.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier family 22 member 2 IC50 1200.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier family 22 member 3 IC50 9500.0 nM 10.1021/jm301302s
Homo sapiens Spermidine/spermine N(1)-acetyltransferase 1 Ki 2000.0 nM 10.1016/j.bmc.2014.02.049
Homo sapiens SR GI50 100000.0 nM None
Homo sapiens SW-620 GI50 18155.16 nM None
Homo sapiens T47D GI50 7762.47 nM None
Homo sapiens THP-1 CC50 10000.0 nM 10.1016/j.ejmech.2018.01.043
Homo sapiens THP-1 CC50 10000.0 nM 10.1021/acsmedchemlett.1c00589
Homo sapiens THP-1 CC50 31200.0 nM 10.1016/j.ejmech.2014.12.056
Homo sapiens THP-1 CC50 51800.0 nM 10.1021/acsmedchemlett.2c00170
Homo sapiens THP-1 EC50 15800.0 nM 10.1021/acs.jnatprod.8b00159
Homo sapiens THP-1 IC50 10.0 ug.mL-1 10.1016/j.bmcl.2014.08.060
Homo sapiens THP-1 IC50 7700.0 nM 10.1016/j.ejmech.2016.12.019
Homo sapiens THP-1 IC50 31200.0 nM 10.1016/j.bmc.2010.06.099
Homo sapiens THP-1 IC50 31200.0 nM 10.1016/j.bmc.2015.03.064
Homo sapiens THP-1 NOAEL 10.0 uM 10.1021/acs.jmedchem.6b00698
Homo sapiens THP-1 NOAEL 25.0 uM 10.1021/acs.jmedchem.8b02021
Homo sapiens Thrombin AC50 4972.6 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens TK-10 GI50 18923.44 nM None
Homo sapiens Transmembrane protease serine 2 IC50 1200.0 nM 10.1021/acsmedchemlett.3c00035
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens U-251 GI50 8260.38 nM None
Homo sapiens U2OS CC50 nan None 10.1016/j.ejmech.2018.01.043
Homo sapiens U-937 IC50 6020.0 nM 10.1016/j.ejmech.2016.12.019
Homo sapiens UACC-257 GI50 15452.54 nM None
Homo sapiens UACC-62 GI50 12161.86 nM None
Homo sapiens UO-31 GI50 59156.16 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens WI-38 Activity nan None 10.1016/j.ejmech.2016.12.017
Homo sapiens WI-38 GI50 nan None 10.1016/j.ejmech.2016.12.017
Homo sapiens WI-38 IC50 nan None 10.1016/j.ejmech.2018.01.043
Homo sapiens WM-115 IC50 4800.0 nM 10.1016/j.bmc.2012.12.042
Leishmania Leishmania Activity 90.0 % 10.1016/j.bmc.2017.01.034
Leishmania amazonensis Leishmania amazonensis Activity 81.0 % 10.1016/j.ejmech.2019.03.032
Leishmania amazonensis Leishmania amazonensis Activity 100.0 % 10.1016/j.ejmech.2008.06.024
Leishmania amazonensis Leishmania amazonensis Activity 100.0 % 10.1021/jm0600343
Leishmania amazonensis Leishmania amazonensis Activity nan None 10.1021/np000527p
Leishmania amazonensis Leishmania amazonensis Activity nan None 10.1021/np50109a003
Leishmania amazonensis Leishmania amazonensis Activity nan None 10.1021/np960148p
Leishmania amazonensis Leishmania amazonensis EC50 460.0 nM 10.1007/s00044-011-9654-9
Leishmania amazonensis Leishmania amazonensis EC50 800.0 nM 10.1016/j.bmc.2019.05.026
Leishmania amazonensis Leishmania amazonensis EC50 6250.0 nM 10.1016/j.bmcl.2015.05.072
Leishmania amazonensis Leishmania amazonensis EC50 10190.0 nM 10.1016/j.bmcl.2015.05.072
Leishmania amazonensis Leishmania amazonensis Efficacy 93.8 % 10.1016/j.ejmech.2015.06.014
Leishmania amazonensis Leishmania amazonensis FC 3.0 None 10.1128/aac.00404-07
Leishmania amazonensis Leishmania amazonensis GI 86.0 % 10.1016/j.bmc.2008.05.074
Leishmania amazonensis Leishmania amazonensis IC50 0.44 ug.mL-1 10.1016/j.bmc.2013.03.045
Leishmania amazonensis Leishmania amazonensis IC50 1.3 ug.mL-1 10.1016/s0960-894x(01)00387-0
Leishmania amazonensis Leishmania amazonensis IC50 6.8 ug.mL-1 10.1128/aac.00404-07
Leishmania amazonensis Leishmania amazonensis IC50 10.0 ug.mL-1 10.1021/np800104p
Leishmania amazonensis Leishmania amazonensis IC50 21.0 nM 10.1016/j.bmc.2017.09.035
Leishmania amazonensis Leishmania amazonensis IC50 290.0 nM 10.1016/j.bmc.2008.05.074
Leishmania amazonensis Leishmania amazonensis IC50 460.0 nM 10.1016/j.ejmech.2007.02.020
Leishmania amazonensis Leishmania amazonensis IC50 480.0 ug.mL-1 10.1016/s0960-894x(99)00453-9
Leishmania amazonensis Leishmania amazonensis IC50 490.0 nM 10.1016/j.bmc.2010.09.015
Leishmania amazonensis Leishmania amazonensis IC50 830.0 nM 10.1016/j.ejmech.2014.06.022
Leishmania amazonensis Leishmania amazonensis IC50 830.0 nM 10.1128/aac.00250-10
Leishmania amazonensis Leishmania amazonensis IC50 900.0 nM 10.1016/j.ejmech.2007.11.007
Leishmania amazonensis Leishmania amazonensis IC50 1050.0 nM 10.1016/j.ejmech.2013.06.040
Leishmania amazonensis Leishmania amazonensis IC50 1500.0 nM 10.1016/j.bmc.2011.09.025
Leishmania amazonensis Leishmania amazonensis IC50 1800.0 nM 10.1016/j.ejmech.2015.06.014
Leishmania amazonensis Leishmania amazonensis IC50 1800.0 nM 10.1016/j.ejmech.2018.01.046
Leishmania amazonensis Leishmania amazonensis IC50 1900.0 nM 10.1016/j.ejmech.2015.09.009
Leishmania amazonensis Leishmania amazonensis IC50 1900.0 nM 10.1016/j.ejmech.2018.02.029
Leishmania amazonensis Leishmania amazonensis IC50 2200.0 nM 10.1016/j.bmc.2011.09.025
Leishmania amazonensis Leishmania amazonensis IC50 3380.0 nM 10.1016/j.bmcl.2013.09.062
Leishmania amazonensis Leishmania amazonensis IC50 4200.0 nM 10.1016/j.ejmech.2018.01.046
Leishmania amazonensis Leishmania amazonensis IC50 4800.0 nM 10.1016/j.ejmech.2015.09.009
Leishmania amazonensis Leishmania amazonensis IC50 5070.0 nM 10.1016/j.ejmech.2019.03.032
Leishmania amazonensis Leishmania amazonensis IC50 5700.0 nM 10.1016/j.ejmech.2018.02.029
Leishmania amazonensis Leishmania amazonensis IC50 6620.0 nM 10.1016/j.ejmech.2015.06.005
Leishmania amazonensis Leishmania amazonensis IC50 6700.0 nM 10.1016/j.bmcl.2015.06.085
Leishmania amazonensis Leishmania amazonensis IC50 7000.0 nM 10.1021/np300077r
Leishmania amazonensis Leishmania amazonensis IC50 7600.0 nM 10.1016/j.ejmech.2019.03.032
Leishmania amazonensis Leishmania amazonensis IC50 9800.0 nM 10.1016/j.ejmech.2007.11.007
Leishmania amazonensis Leishmania amazonensis IC50 10000.0 nM 10.1016/j.bmc.2017.09.035
Leishmania amazonensis Leishmania amazonensis IC50 10000.0 nM 10.1016/j.bmcl.2011.09.134
Leishmania amazonensis Leishmania amazonensis IC50 12290.0 nM 10.1016/j.ejmech.2021.113606
Leishmania amazonensis Leishmania amazonensis IC50 14320.0 nM 10.1016/j.bmc.2014.01.029
Leishmania amazonensis Leishmania amazonensis IC50 14320.0 nM 10.1016/j.bmcl.2017.05.071
Leishmania amazonensis Leishmania amazonensis IC50 29400.0 nM 10.1016/j.bmcl.2007.10.102
Leishmania amazonensis Leishmania amazonensis IC50 820351.54 nM 10.1021/jm970488n
Leishmania amazonensis Leishmania amazonensis IC90 1.0 ug 10.1021/np50074a015
Leishmania amazonensis Leishmania amazonensis Inhibition 100.0 % 10.1007/s00044-011-9654-9
Leishmania amazonensis Leishmania amazonensis Inhibition 100.0 % 10.1021/np9800654
Leishmania amazonensis Leishmania amazonensis Inhibition nan % 10.1016/j.ejmech.2015.09.009
Leishmania amazonensis Leishmania amazonensis Leishmanicidal activity nan None 10.1016/s0960-894x(99)00453-9
Leishmania aristidesi Leishmania aristidesi IC90 1.0 ug 10.1021/np50074a015
Leishmania braziliensis Leishmania braziliensis Activity 100.0 % 10.1016/j.ejmech.2008.06.024
Leishmania braziliensis Leishmania braziliensis Activity 100.0 % 10.1021/jm0600343
Leishmania braziliensis Leishmania braziliensis Activity nan None 10.1021/np000527p
Leishmania braziliensis Leishmania braziliensis Activity nan None 10.1021/np50109a003
Leishmania braziliensis Leishmania braziliensis Activity nan None 10.1021/np960148p
Leishmania braziliensis Leishmania braziliensis ED50 64.18 uM 10.1016/j.ejmech.2006.12.026
Leishmania braziliensis Leishmania braziliensis Efficacy 95.7 % 10.1016/j.ejmech.2015.06.014
Leishmania braziliensis Leishmania braziliensis IC50 1.3 ug.mL-1 10.1016/s0960-894x(01)00387-0
Leishmania braziliensis Leishmania braziliensis IC50 10.0 ug.mL-1 10.1021/np800104p
Leishmania braziliensis Leishmania braziliensis IC50 60.0 nM 10.1016/j.ejmech.2015.06.014
Leishmania braziliensis Leishmania braziliensis IC50 150.0 nM 10.1016/j.bmc.2010.09.015
Leishmania braziliensis Leishmania braziliensis IC50 1360.0 nM 10.1016/j.ejmech.2013.06.040
Leishmania braziliensis Leishmania braziliensis IC50 2900.0 nM 10.1021/np050422s
Leishmania braziliensis Leishmania braziliensis IC50 6000.0 nM 10.1016/j.bmc.2011.06.023
Leishmania braziliensis Leishmania braziliensis IC50 9800.0 nM 10.1016/j.ejmech.2007.11.007
Leishmania braziliensis Leishmania braziliensis IC50 13000.0 nM 10.1016/j.bmcl.2013.09.062
Leishmania braziliensis Leishmania braziliensis IC50 29400.0 nM 10.1016/j.bmcl.2007.10.102
Leishmania braziliensis Leishmania braziliensis IC50 48500.0 nM 10.1016/j.ejmech.2009.12.061
Leishmania braziliensis Leishmania braziliensis IC50 50000.0 nM 10.1016/j.bmcl.2011.09.134
Leishmania braziliensis Leishmania braziliensis IC90 1.0 ug 10.1021/np50074a015
Leishmania braziliensis Leishmania braziliensis IC90 1.0 ug.mL-1 10.1021/np50099a013
Leishmania braziliensis Leishmania braziliensis Inhibition 100.0 % 10.1021/np9800654
Leishmania braziliensis Leishmania braziliensis Leishmanicidal activity nan None 10.1016/s0960-894x(99)00453-9
Leishmania chagasi Leishmania chagasi EC50 5.2 ug.mL-1 10.1016/j.ejmech.2020.112514
Leishmania chagasi Leishmania chagasi ED50 27.5 uM 10.1016/j.ejmech.2006.12.026
Leishmania chagasi Leishmania chagasi IC50 0.1 ug.mL-1 10.1021/np0705256
Leishmania chagasi Leishmania chagasi IC50 1110.0 nM 10.1016/j.bmc.2010.09.015
Leishmania chagasi Leishmania chagasi IC50 1760.0 nM 10.1016/j.ejmech.2013.06.040
Leishmania chagasi Leishmania chagasi IC50 5100.0 nM 10.1021/np300077r
Leishmania chagasi Leishmania chagasi IC50 nan None 10.1016/j.bmc.2010.09.015
Leishmania chagasi Leishmania chagasi IC50 nan None 10.1021/np0705256
Leishmania chagasi Leishmania chagasi IC90 1.0 ug 10.1021/np50074a015
Leishmania chagasi Leishmania chagasi Inhibition 100.0 % 10.1021/np9800654
Leishmania donovani Leishmania donovani Activity 84.1 % 10.1016/j.ejmech.2009.01.016
Leishmania donovani Leishmania donovani Activity 85.0 % 10.1016/j.ejmech.2009.01.016
Leishmania donovani Leishmania donovani Activity nan None 10.1016/j.bmcl.2008.11.094
Leishmania donovani Leishmania donovani Activity nan None 10.1021/np000527p
Leishmania donovani Leishmania donovani Activity nan None 10.1021/np0702281
Leishmania donovani Leishmania donovani Activity nan None 10.1021/np50109a003
Leishmania donovani Leishmania donovani Activity nan None 10.1021/np960148p
Leishmania donovani Leishmania donovani EC50 1.41 ug.mL-1 10.1016/j.ejmech.2020.112514
Leishmania donovani Leishmania donovani EC50 3.1 ug.mL-1 10.1021/np2004825
Leishmania donovani Leishmania donovani EC50 1350.0 nM 10.1007/s00044-006-0142-6
Leishmania donovani Leishmania donovani EC50 1600.0 nM 10.1016/j.ejmech.2018.03.022
Leishmania donovani Leishmania donovani EC50 5000.0 nM 10.1007/s00044-005-0126-y
Leishmania donovani Leishmania donovani EC50 6400.0 nM 10.1016/j.ejmech.2018.03.022
Leishmania donovani Leishmania donovani EC50 23700.0 nM 10.1016/j.ejmech.2018.03.022
Leishmania donovani Leishmania donovani EC50 1700000.0 nM 10.1128/aac.01193-06
Leishmania donovani Leishmania donovani EC50 1900000.0 nM 10.1128/aac.01193-06
Leishmania donovani Leishmania donovani EC50 2000000.0 nM 10.1128/aac.01193-06
Leishmania donovani Leishmania donovani EC50 2600000.0 nM 10.1128/aac.01193-06
Leishmania donovani Leishmania donovani ED50 28.9 uM 10.1021/jm0504860
Leishmania donovani Leishmania donovani ED50 nan None 10.1016/s0960-894x(00)00154-2
Leishmania donovani Leishmania donovani Growth inhibition 100.0 % 10.1016/S0960-894X(97)00166-2
Leishmania donovani Leishmania donovani Growth inhibition 100.0 % 10.1016/S0960-894X(97)10153-6
Leishmania donovani Leishmania donovani IC50 0.24 ug.mL-1 10.1021/np010419i
Leishmania donovani Leishmania donovani IC50 0.4 ug.mL-1 10.1016/j.bmcl.2014.08.060
Leishmania donovani Leishmania donovani IC50 0.42 ug.mL-1 10.1021/np030045o
Leishmania donovani Leishmania donovani IC50 0.5 ug.mL-1 10.1021/np800653z
Leishmania donovani Leishmania donovani IC50 0.58 ug.mL-1 10.1016/j.ejmech.2006.11.011
Leishmania donovani Leishmania donovani IC50 0.6 ug.mL-1 10.1016/j.bmcl.2014.08.060
Leishmania donovani Leishmania donovani IC50 0.64 ug.mL-1 10.1016/j.ejmech.2021.113606
Leishmania donovani Leishmania donovani IC50 0.643 ug.mL-1 10.1016/j.bmcl.2008.11.094
Leishmania donovani Leishmania donovani IC50 0.643 ug.mL-1 10.1016/j.bmcl.2009.03.020
Leishmania donovani Leishmania donovani IC50 0.643 ug.mL-1 10.1016/j.bmcl.2009.10.117
Leishmania donovani Leishmania donovani IC50 0.7 ug.mL-1 10.1016/j.bmc.2006.10.062
Leishmania donovani Leishmania donovani IC50 0.7 ug.mL-1 10.1021/np030086k
Leishmania donovani Leishmania donovani IC50 0.9 ug.mL-1 10.1016/j.bmc.2009.10.042
Leishmania donovani Leishmania donovani IC50 0.9 ug.mL-1 10.1021/np800163u
Leishmania donovani Leishmania donovani IC50 1.0 ug.mL-1 10.1007/s00044-011-9798-7
Leishmania donovani Leishmania donovani IC50 1.0 ug.mL-1 10.1016/j.bmc.2006.10.036
Leishmania donovani Leishmania donovani IC50 1.0 ug.mL-1 10.1016/j.bmc.2010.11.036
Leishmania donovani Leishmania donovani IC50 1.0 ug.mL-1 10.1016/j.ejmech.2012.03.019
Leishmania donovani Leishmania donovani IC50 1.0 ug.mL-1 10.1016/j.ejmech.2017.11.043
Leishmania donovani Leishmania donovani IC50 1.0 ug.mL-1 10.1039/C0MD00267D
Leishmania donovani Leishmania donovani IC50 1.01 ug.mL-1 10.1007/s00044-013-0572-x
Leishmania donovani Leishmania donovani IC50 1.17 ug.mL-1 10.1021/jm100507q
Leishmania donovani Leishmania donovani IC50 1.2 ug.mL-1 10.1016/j.bmc.2007.10.055
Leishmania donovani Leishmania donovani IC50 1.3 ug.mL-1 10.1016/s0960-894x(01)00387-0
Leishmania donovani Leishmania donovani IC50 1.4 ug.mL-1 10.1021/np049682k
Leishmania donovani Leishmania donovani IC50 1.5 ug.mL-1 10.1016/j.bmc.2006.10.006
Leishmania donovani Leishmania donovani IC50 1.6 ug.mL-1 10.1021/np030524n
Leishmania donovani Leishmania donovani IC50 1.6 ug.mL-1 10.1021/np050500b
Leishmania donovani Leishmania donovani IC50 1.885 ug.mL-1 10.1016/j.bmcl.2015.10.062
Leishmania donovani Leishmania donovani IC50 1.9 nM 10.1016/j.ejmech.2006.11.006
Leishmania donovani Leishmania donovani IC50 2.1 ug.mL-1 10.1007/s00044-012-0355-9
Leishmania donovani Leishmania donovani IC50 2.1 ug.mL-1 10.1016/j.ejmech.2008.04.014
Leishmania donovani Leishmania donovani IC50 2.1 ug.mL-1 10.1021/np020592u
Leishmania donovani Leishmania donovani IC50 2.1 ug.mL-1 10.1021/np0400095
Leishmania donovani Leishmania donovani IC50 2.1 ug.mL-1 10.1021/np0601399
Leishmania donovani Leishmania donovani IC50 2.8 ug.mL-1 10.1007/s00044-012-0355-9
Leishmania donovani Leishmania donovani IC50 2.8 ug.mL-1 10.1016/j.bmc.2006.11.024
Leishmania donovani Leishmania donovani IC50 2.8 ug.mL-1 10.1016/j.ejmech.2008.04.014
Leishmania donovani Leishmania donovani IC50 3.23 ug.mL-1 10.1016/j.ejmech.2010.02.018
Leishmania donovani Leishmania donovani IC50 3.59 ug.mL-1 10.1016/j.ejmech.2010.02.018
Leishmania donovani Leishmania donovani IC50 4.1 nM 10.1021/np4006822
Leishmania donovani Leishmania donovani IC50 5.5 ug.mL-1 10.1016/j.bmcl.2015.12.085
Leishmania donovani Leishmania donovani IC50 8.9 ug.mL-1 10.1016/j.bmcl.2014.08.060
Leishmania donovani Leishmania donovani IC50 10.0 ug.mL-1 10.1021/np800104p
Leishmania donovani Leishmania donovani IC50 12.11 ug.mL-1 10.1016/j.bmcl.2008.11.094
Leishmania donovani Leishmania donovani IC50 12.11 ug.mL-1 10.1016/j.bmcl.2009.03.020
Leishmania donovani Leishmania donovani IC50 12.11 ug.mL-1 10.1016/j.bmcl.2009.07.081
Leishmania donovani Leishmania donovani IC50 12.11 ug.mL-1 10.1016/j.bmcl.2009.10.117
Leishmania donovani Leishmania donovani IC50 12.11 ug.mL-1 10.1016/j.ejmech.2009.01.016
Leishmania donovani Leishmania donovani IC50 12.11 ug.mL-1 10.1016/j.ejmech.2010.04.004
Leishmania donovani Leishmania donovani IC50 16.15 ug.mL-1 10.1016/j.bmcl.2017.12.013
Leishmania donovani Leishmania donovani IC50 450.0 ug.mL-1 10.1016/s0960-894x(99)00453-9
Leishmania donovani Leishmania donovani IC50 760.0 nM 10.1016/S0960-894X(97)00166-2
Leishmania donovani Leishmania donovani IC50 1000.0 nM 10.1016/j.bmc.2010.01.068
Leishmania donovani Leishmania donovani IC50 1000.0 nM 10.1128/aac.01544-06
Leishmania donovani Leishmania donovani IC50 1060.0 nM 10.1016/j.bmc.2008.05.076
Leishmania donovani Leishmania donovani IC50 1300.0 nM 10.1021/np0702281
Leishmania donovani Leishmania donovani IC50 1350.0 nM 10.1021/jm030181q
Leishmania donovani Leishmania donovani IC50 1500.0 nM 10.1021/np0502600
Leishmania donovani Leishmania donovani IC50 1610.0 nM 10.1016/s0960-894x(02)00465-1
Leishmania donovani Leishmania donovani IC50 1800.0 nM 10.1021/jm800918v
Leishmania donovani Leishmania donovani IC50 1800.0 nM 10.1021/jm9006406
Leishmania donovani Leishmania donovani IC50 1800.0 nM 10.1021/jm900805v
Leishmania donovani Leishmania donovani IC50 1800.0 nM 10.1021/jm901178d
Leishmania donovani Leishmania donovani IC50 1800.0 nM 10.1128/aac.00250-10
Leishmania donovani Leishmania donovani IC50 1830.0 nM 10.1021/jm0708634
Leishmania donovani Leishmania donovani IC50 1840.0 nM 10.1016/j.ejmech.2009.03.014
Leishmania donovani Leishmania donovani IC50 1840.0 nM 10.1016/j.ejmech.2013.06.033
Leishmania donovani Leishmania donovani IC50 2000.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC50 2000.0 nM 10.1016/s0960-894x(02)00465-1
Leishmania donovani Leishmania donovani IC50 2000.0 nM 10.1021/jm0304461
Leishmania donovani Leishmania donovani IC50 2000.0 nM 10.1021/jm0493717
Leishmania donovani Leishmania donovani IC50 2200.0 nM 10.1016/j.bmc.2008.11.031
Leishmania donovani Leishmania donovani IC50 2200.0 nM 10.1016/j.bmcl.2008.03.020
Leishmania donovani Leishmania donovani IC50 2300.0 nM 10.1016/j.bmc.2007.06.042
Leishmania donovani Leishmania donovani IC50 2500.0 nM 10.1021/jm0505765
Leishmania donovani Leishmania donovani IC50 2600.0 nM 10.1016/s0960-894x(03)00319-6
Leishmania donovani Leishmania donovani IC50 2630.0 nM 10.6019/CHEMBL3392926
Leishmania donovani Leishmania donovani IC50 2790.0 nM 10.1016/j.bmcl.2020.127491
Leishmania donovani Leishmania donovani IC50 2800.0 nM 10.1016/j.bmc.2009.10.019
Leishmania donovani Leishmania donovani IC50 2840.0 nM 10.1016/j.ejmech.2012.03.003
Leishmania donovani Leishmania donovani IC50 2900.0 nM 10.1016/j.ejmech.2013.02.024
Leishmania donovani Leishmania donovani IC50 2900.0 nM 10.1021/np200940b
Leishmania donovani Leishmania donovani IC50 3100.0 nM 10.1016/j.bmcl.2019.126725
Leishmania donovani Leishmania donovani IC50 3100.0 nM 10.1016/j.ejmech.2013.06.002
Leishmania donovani Leishmania donovani IC50 3200.0 nM 10.1021/np5000473
Leishmania donovani Leishmania donovani IC50 3290.0 nM 10.1016/j.ejmech.2013.02.024
Leishmania donovani Leishmania donovani IC50 3290.0 nM 10.1039/C3MD00097D
Leishmania donovani Leishmania donovani IC50 3500.0 nM 10.1016/j.bmc.2008.11.050
Leishmania donovani Leishmania donovani IC50 3800.0 nM 10.1021/np900067k
Leishmania donovani Leishmania donovani IC50 3820.0 nM 10.1039/C2MD20143G
Leishmania donovani Leishmania donovani IC50 4210.0 nM 10.1016/j.bmcl.2014.11.073
Leishmania donovani Leishmania donovani IC50 4400.0 nM 10.1039/d0md00291g
Leishmania donovani Leishmania donovani IC50 4800.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC50 5300.0 nM 10.1021/jm301172v
Leishmania donovani Leishmania donovani IC50 5500.0 nM 10.1016/j.ejmech.2014.05.037
Leishmania donovani Leishmania donovani IC50 5520.0 nM 10.1016/j.ejmech.2014.07.113
Leishmania donovani Leishmania donovani IC50 6000.0 nM 10.1016/j.bmc.2013.09.002
Leishmania donovani Leishmania donovani IC50 6000.0 nM 10.1016/j.bmc.2015.03.064
Leishmania donovani Leishmania donovani IC50 6000.0 nM 10.1016/j.ejmech.2012.04.029
Leishmania donovani Leishmania donovani IC50 6000.0 nM 10.1016/j.ejmech.2014.12.056
Leishmania donovani Leishmania donovani IC50 6000.0 nM 10.1021/acsmedchemlett.8b00347
Leishmania donovani Leishmania donovani IC50 6200.0 nM 10.1016/j.bmcl.2011.12.101
Leishmania donovani Leishmania donovani IC50 6200.0 nM 10.1039/C7MD00008A
Leishmania donovani Leishmania donovani IC50 6290.0 nM 10.1016/j.ejmech.2011.04.026
Leishmania donovani Leishmania donovani IC50 6500.0 nM 10.1016/j.bmcl.2009.12.102
Leishmania donovani Leishmania donovani IC50 6600.0 nM 10.1016/j.bmcl.2006.07.042
Leishmania donovani Leishmania donovani IC50 6600.0 nM 10.1016/j.ejmech.2012.03.003
Leishmania donovani Leishmania donovani IC50 9000.0 nM 10.1021/acs.jnatprod.8b00473
Leishmania donovani Leishmania donovani IC50 9300.0 nM 10.1016/s0960-894x(03)00319-6
Leishmania donovani Leishmania donovani IC50 9800.0 nM 10.1016/j.ejmech.2007.11.007
Leishmania donovani Leishmania donovani IC50 11200.0 nM 10.1016/j.bmc.2010.06.099
Leishmania donovani Leishmania donovani IC50 13680.0 nM 10.1021/ml400317e
Leishmania donovani Leishmania donovani IC50 13900.0 nM 10.1021/jm301172v
Leishmania donovani Leishmania donovani IC50 14000.0 nM 10.1128/aac.00250-10
Leishmania donovani Leishmania donovani IC50 16150.0 nM 10.1016/j.bmcl.2014.01.035
Leishmania donovani Leishmania donovani IC50 16150.0 nM 10.1016/j.bmcl.2016.12.018
Leishmania donovani Leishmania donovani IC50 19770.0 nM 10.6019/CHEMBL3392926
Leishmania donovani Leishmania donovani IC50 20000.0 nM 10.1016/j.bmc.2013.09.002
Leishmania donovani Leishmania donovani IC50 20000.0 nM 10.1016/j.bmc.2015.03.064
Leishmania donovani Leishmania donovani IC50 20000.0 nM 10.1016/j.ejmech.2012.04.029
Leishmania donovani Leishmania donovani IC50 20000.0 nM 10.1016/j.ejmech.2014.12.056
Leishmania donovani Leishmania donovani IC50 20430.0 nM 10.1016/j.bmcl.2010.08.119
Leishmania donovani Leishmania donovani IC50 20430.0 nM 10.1016/j.bmcl.2012.10.101
Leishmania donovani Leishmania donovani IC50 20430.0 nM 10.1016/j.ejmech.2010.02.015
Leishmania donovani Leishmania donovani IC50 29400.0 nM 10.1016/j.bmcl.2007.10.102
Leishmania donovani Leishmania donovani IC50 29400.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC50 30000.0 nM 10.1021/jm301172v
Leishmania donovani Leishmania donovani IC50 50000.0 nM 10.1128/aac.00250-10
Leishmania donovani Leishmania donovani IC50 54800.0 nM 10.1021/jm301172v
Leishmania donovani Leishmania donovani IC90 0.88 ug.mL-1 10.1016/j.ejmech.2006.11.011
Leishmania donovani Leishmania donovani IC90 1.5 ug.mL-1 10.1021/np030045o
Leishmania donovani Leishmania donovani IC90 1.8 ug.mL-1 10.1016/j.bmc.2009.10.042
Leishmania donovani Leishmania donovani IC90 1.8 ug.mL-1 10.1021/np800163u
Leishmania donovani Leishmania donovani IC90 2.0 ug.mL-1 10.1016/j.ejmech.2017.11.043
Leishmania donovani Leishmania donovani IC90 2.0 ug.mL-1 10.1021/np800653z
Leishmania donovani Leishmania donovani IC90 2.03 ug.mL-1 10.1007/s00044-013-0572-x
Leishmania donovani Leishmania donovani IC90 2.4 ug.mL-1 10.1021/np030086k
Leishmania donovani Leishmania donovani IC90 2.45 ug.mL-1 10.1021/jm100507q
Leishmania donovani Leishmania donovani IC90 3.5 ug.mL-1 10.1021/np030524n
Leishmania donovani Leishmania donovani IC90 3.8 ug.mL-1 10.1016/j.bmc.2006.10.036
Leishmania donovani Leishmania donovani IC90 3.8 ug.mL-1 10.1016/j.bmc.2010.11.036
Leishmania donovani Leishmania donovani IC90 3.8 ug.mL-1 10.1016/j.ejmech.2012.03.019
Leishmania donovani Leishmania donovani IC90 3.8 ug.mL-1 10.1039/C0MD00267D
Leishmania donovani Leishmania donovani IC90 4.9 ug.mL-1 10.1016/j.bmc.2006.10.006
Leishmania donovani Leishmania donovani IC90 5.81 ug.mL-1 10.1016/j.bmcl.2015.10.062
Leishmania donovani Leishmania donovani IC90 6.0 ug.mL-1 10.1016/j.bmc.2007.10.055
Leishmania donovani Leishmania donovani IC90 6.6 ug.mL-1 10.1021/np050500b
Leishmania donovani Leishmania donovani IC90 10.0 ug.mL-1 10.1016/j.bmc.2006.11.024
Leishmania donovani Leishmania donovani IC90 10.0 ug.mL-1 10.1021/np020592u
Leishmania donovani Leishmania donovani IC90 10.0 ug.mL-1 10.1021/np0400095
Leishmania donovani Leishmania donovani IC90 10.0 ug.mL-1 10.1021/np0601399
Leishmania donovani Leishmania donovani IC90 3100.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC90 5290.0 nM 10.1016/j.bmcl.2020.127491
Leishmania donovani Leishmania donovani IC90 5580.0 nM 10.1021/np200940b
Leishmania donovani Leishmania donovani IC90 5900.0 nM 10.1021/np5000473
Leishmania donovani Leishmania donovani IC90 6100.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani IC90 6210.0 nM 10.1016/j.ejmech.2013.02.024
Leishmania donovani Leishmania donovani IC90 6210.0 nM 10.1039/C3MD00097D
Leishmania donovani Leishmania donovani IC90 6400.0 nM 10.1016/j.bmc.2009.10.019
Leishmania donovani Leishmania donovani IC90 8300.0 nM 10.1021/jm0505765
Leishmania donovani Leishmania donovani IC90 9800.0 nM 10.1016/j.bmcl.2008.03.020
Leishmania donovani Leishmania donovani IC90 12400.0 nM 10.1039/C2MD20143G
Leishmania donovani Leishmania donovani IC90 14300.0 nM 10.1016/j.ejmech.2013.02.024
Leishmania donovani Leishmania donovani IC90 14700.0 nM 10.1016/j.bmc.2008.11.050
Leishmania donovani Leishmania donovani IC90 17000.0 nM 10.1021/acs.jnatprod.8b00473
Leishmania donovani Leishmania donovani IC90 19100.0 nM 10.1021/np900067k
Leishmania donovani Leishmania donovani IC90 29400.0 nM 10.1016/j.bmcl.2014.06.030
Leishmania donovani Leishmania donovani Inhibition 30.0 % 10.1016/j.bmcl.2007.04.035
Leishmania donovani Leishmania donovani Inhibition 48.0 % 10.1016/j.bmcl.2006.02.012
Leishmania donovani Leishmania donovani Inhibition 50.0 % 10.1016/j.bmcl.2004.05.071
Leishmania donovani Leishmania donovani Inhibition 71.0 % 10.1016/j.bmcl.2006.02.012
Leishmania donovani Leishmania donovani Inhibition 85.0 % 10.1016/j.bmcl.2007.04.035
Leishmania donovani Leishmania donovani Inhibition 85.0 % 10.1016/j.ejmech.2010.02.015
Leishmania donovani Leishmania donovani Inhibition 90.0 % 10.1016/j.bmcl.2007.04.035
Leishmania donovani Leishmania donovani Inhibition 92.0 % 10.1016/j.bmcl.2008.11.094
Leishmania donovani Leishmania donovani Inhibition 92.0 % 10.1016/j.bmcl.2009.10.117
Leishmania donovani Leishmania donovani Inhibition 92.0 % 10.1016/j.ejmech.2010.02.018
Leishmania donovani Leishmania donovani Inhibition 97.0 % 10.1016/j.bmcl.2004.05.071
Leishmania donovani Leishmania donovani Inhibition 100.0 % 10.1016/j.bmcl.2008.11.094
Leishmania donovani Leishmania donovani Inhibition 100.0 % 10.1016/j.bmcl.2009.07.081
Leishmania donovani Leishmania donovani Inhibition 100.0 % 10.1016/j.ejmech.2010.04.004
Leishmania donovani Leishmania donovani Inhibition 100.0 % 10.1016/S0960-894X(97)00086-3
Leishmania donovani Leishmania donovani Inhibition nan % 10.1021/np0702281
Leishmania donovani Leishmania donovani Leishmanicidal activity nan None 10.1016/s0960-894x(99)00453-9
Leishmania donovani Leishmania donovani MIC 168710.0 nM 10.1016/j.ejmech.2010.02.015
Leishmania donovani Leishmania donovani Ratio IC50 3.9 None 10.1021/jm301172v
Leishmania donovani donovani Leishmania donovani donovani IC90 1.0 ug 10.1021/np50074a015
Leishmania garnhami Leishmania garnhami IC90 1.0 ug 10.1021/np50074a015
Leishmania guyanensis Leishmania guyanensis IC50 900.0 nM 10.1021/np050422s
Leishmania guyanensis Leishmania guyanensis IC90 5.0 ug 10.1021/np50074a015
Leishmania infantum Leishmania infantum Activity 100.0 % 10.1016/j.ejmech.2008.06.024
Leishmania infantum Leishmania infantum Activity 100.0 % 10.1021/jm0600343
Leishmania infantum Leishmania infantum EC50 5.3 ug.mL-1 10.1016/j.bmc.2014.08.020
Leishmania infantum Leishmania infantum EC50 2700.0 nM 10.1016/j.ejmech.2018.03.022
Leishmania infantum Leishmania infantum EC50 8310.0 nM 10.1016/j.ejmech.2018.03.022
Leishmania infantum Leishmania infantum EC50 19770.0 nM 10.1016/j.bmcl.2015.05.072
Leishmania infantum Leishmania infantum EC50 67710.0 nM 10.1016/j.bmcl.2015.05.072
Leishmania infantum Leishmania infantum EC50 nan None 10.1016/j.bmc.2014.08.020
Leishmania infantum Leishmania infantum EC50 nan None 10.1016/j.ejmech.2018.01.043
Leishmania infantum Leishmania infantum FC 3.0 None 10.1128/aac.00404-07
Leishmania infantum Leishmania infantum IC50 10.0 ug.mL-1 10.1128/aac.00404-07
Leishmania infantum Leishmania infantum IC50 62.0 nM 10.1016/j.bmc.2017.09.035
Leishmania infantum Leishmania infantum IC50 8200.0 nM 10.1016/j.bmc.2013.09.002
Leishmania infantum Leishmania infantum IC50 8200.0 nM 10.1016/j.ejmech.2012.04.029
Leishmania infantum Leishmania infantum IC50 20000.0 nM 10.1016/j.bmc.2015.03.064
Leishmania infantum Leishmania infantum IC50 100000.0 nM 10.1016/j.bmcl.2011.09.134
Leishmania infantum Leishmania infantum IC50 nan None 10.1021/acsmedchemlett.2c00170
Leishmania infantum Leishmania infantum IC90 1.0 ug 10.1021/np50074a015
Leishmania infantum Leishmania infantum Inhibition nan % 10.1021/acsmedchemlett.1c00589
Leishmania infantum Leishmania infantum Inhibition nan % 10.1021/acsmedchemlett.2c00170
Leishmania major Leishmania major EC50 1.46 ug.mL-1 10.1016/j.ejmech.2020.112514
Leishmania major Leishmania major EC50 280.0 nM 10.1128/aac.01545-10
Leishmania major Leishmania major EC50 450.0 nM 10.1128/aac.01545-10
Leishmania major Leishmania major EC50 3800.0 nM 10.1016/j.ejmech.2009.11.035
Leishmania major Leishmania major EC50 4300.0 nM 10.1021/ml200160k
Leishmania major Leishmania major FC 3.0 None 10.1128/aac.00404-07
Leishmania major Leishmania major IC50 0.6 ug.mL-1 10.1021/np050520d
Leishmania major Leishmania major IC50 5.1 ug.mL-1 10.1128/aac.00404-07
Leishmania major Leishmania major IC50 470.0 nM 10.1016/j.bmc.2010.09.015
Leishmania major Leishmania major IC50 3000.0 nM 10.1016/j.ejmech.2015.09.002
Leishmania major Leishmania major IC50 3520.0 nM 10.1128/aac.00425-07
Leishmania major Leishmania major IC50 4300.0 nM 10.1016/j.ejmech.2014.05.037
Leishmania major Leishmania major IC50 4320.0 nM 10.1021/np800161j
Leishmania major Leishmania major IC50 4600.0 nM 10.1016/j.ejmech.2015.09.002
Leishmania major Leishmania major IC50 4800.0 nM 10.1016/j.ejmech.2012.10.048
Leishmania major Leishmania major IC50 5090.0 nM 10.1016/j.bmcl.2013.03.051
Leishmania major Leishmania major IC50 5090.0 nM 10.1016/j.ejmech.2015.11.016
Leishmania major Leishmania major IC50 7020.0 nM 10.1016/j.ejmech.2014.07.078
Leishmania major Leishmania major IC50 7020.0 nM 10.1016/j.ejmech.2016.12.019
Leishmania major Leishmania major IC50 7500.0 nM 10.1021/np800305b
Leishmania major Leishmania major IC50 14950.0 nM 10.1016/j.bmcl.2018.07.045
Leishmania major Leishmania major IC50 nan None 10.1128/aac.00250-10
Leishmania major Leishmania major IC90 1.9 ug.mL-1 10.1021/np050520d
Leishmania major Leishmania major Inhibition 99.0 % 10.1016/j.ejmech.2012.10.048
Leishmania major Leishmania major MIC 5220.0 nM 10.1016/j.ejmech.2020.113102
Leishmania major Leishmania major Ratio EC50 1.8 None 10.1128/aac.01545-10
Leishmania mexicana Leishmania mexicana EC50 1.75 ug.mL-1 10.1016/j.ejmech.2020.112514
Leishmania mexicana Leishmania mexicana EC50 1630.0 nM 10.1016/j.bmcl.2017.05.052
Leishmania mexicana Leishmania mexicana EC50 1900.0 nM 10.1016/j.bmcl.2017.05.052
Leishmania mexicana Leishmania mexicana EC50 8800.0 nM 10.1021/ml200160k
Leishmania mexicana Leishmania mexicana EC50 16000.0 nM 10.1016/j.ejmech.2009.11.035
Leishmania mexicana Leishmania mexicana IC50 1000.0 nM 10.1016/j.bmc.2010.01.068
Leishmania mexicana Leishmania mexicana IC50 1030.0 ug.mL-1 10.1016/s0960-894x(99)00453-9
Leishmania mexicana Leishmania mexicana IC50 2400.0 nM 10.1016/j.ejmech.2014.05.037
Leishmania mexicana Leishmania mexicana IC50 2421.0 nM 10.1016/j.ejmech.2010.03.050
Leishmania mexicana Leishmania mexicana IC50 9568.0 nM 10.1016/j.bmcl.2008.05.009
Leishmania mexicana Leishmania mexicana IC50 13320.0 nM 10.1016/j.bmc.2010.07.008
Leishmania mexicana Leishmania mexicana IC50 13320.0 nM 10.1016/j.bmcl.2011.02.100
Leishmania mexicana Leishmania mexicana IC50 13320.0 nM 10.1016/j.bmcl.2017.05.071
Leishmania mexicana Leishmania mexicana Ratio EC50 0.86 None 10.1016/j.bmcl.2017.05.052
Leishmania mexicana mexicana Leishmania mexicana mexicana IC90 1.0 ug 10.1021/np50074a015
Leishmania mexicana venezuelensis Leishmania mexicana venezuelensis IC90 5.0 ug 10.1021/np50074a015
Leishmania peruviana Leishmania peruviana IC90 5.0 ug 10.1021/np50074a015
Leishmania pifanoi Leishmania pifanoi IC90 1.0 ug 10.1021/np50074a015
Leishmania sp. Leishmania sp. Inhibition nan % 10.1016/s0960-894x(02)00465-1
Leishmania tarentolae Leishmania tarentolae IC50 30.0 nM 10.1021/jm401007p
Macaca mulatta LLC-MK2 IC50 25610.0 nM 10.1016/j.bmc.2010.09.015
Moloney murine leukemia virus isolate Shinnick Moloney murine leukaemia virus Pol protein ID50 100.0 ug ml-1 10.1021/jm00181a016
Mus musculus Acid-sensing ion channel 1 Inhibition 39.0 % 10.1016/j.bmc.2014.02.049
Mus musculus Acid-sensing ion channel 1 Inhibition 92.0 % 10.1016/j.bmc.2014.02.049
Mus musculus Acid-sensing ion channel 2 Inhibition 51.0 % 10.1016/j.bmc.2014.02.049
Mus musculus Acid-sensing ion channel 3 Inhibition 74.0 % 10.1016/j.bmc.2014.02.049
Mus musculus C2C12 CC50 nan None 10.1021/acs.jmedchem.1c01151
Mus musculus J774 Activity 28.8 % 10.1016/j.ejmech.2015.06.014
Mus musculus J774 IC50 70000.0 nM 10.1016/j.bmc.2011.09.025
Mus musculus J774 IC50 nan nM 10.1021/jm0304461
Mus musculus J774 LC50 100000.0 nM 10.1016/j.ejmech.2015.06.014
Mus musculus J774.1 IC50 38600.0 nM 10.1016/j.bmc.2017.06.051
Mus musculus J774.A1 CC50 3.91 ug.mL-1 10.1016/j.ejmech.2010.02.018
Mus musculus J774.A1 CC50 25.15 ug.mL-1 10.1016/j.ejmech.2010.04.004
Mus musculus J774.A1 CC50 25.15 None 10.1016/j.bmcl.2009.03.020
Mus musculus J774.A1 CC50 31.31 ug.mL-1 10.1016/j.bmcl.2008.11.094
Mus musculus J774.A1 CC50 31.31 ug.mL-1 10.1016/j.bmcl.2009.10.117
Mus musculus J774.A1 CC50 31.31 ug.mL-1 10.1016/j.ejmech.2009.01.016
Mus musculus J774.A1 CC50 1000.0 nM 10.1016/j.ejmech.2012.04.029
Mus musculus J774.A1 CC50 52820.0 nM 10.1016/j.bmcl.2010.08.119
Mus musculus J774.A1 CC50 52820.0 nM 10.1016/j.ejmech.2010.02.015
Mus musculus J774.A1 IC50 12.9 ug.mL-1 10.1021/np049682k
Mus musculus J774.A1 IC50 1030.0 nM 10.1016/j.ejmech.2011.04.026
Mus musculus Monoamine oxidase B Activity nan None 10.1021/jm800656v
Mus musculus Mus musculus Activity nan None 10.1021/jm060470p
Mus musculus Mus musculus CC50 100000.0 nM 10.1016/j.bmc.2016.10.013
Mus musculus Mus musculus Cured/Infected 0.0 None 10.1021/jm050177+
Mus musculus Mus musculus Cured/Infected 4.0 None 10.1021/jm050177+
Mus musculus Mus musculus Cured/Infected nan None 10.1021/jm050177+
Mus musculus Mus musculus Cures 0.0 None 10.1021/jm0302602
Mus musculus Mus musculus Cures 0.0 None 10.1021/jm058190h
Mus musculus Mus musculus Cures 1.0 None 10.1021/jm00179a022
Mus musculus Mus musculus Cures 4.0 None 10.1021/jm00179a022
Mus musculus Mus musculus Cures 5.0 None 10.1021/jm00179a022
Mus musculus Mus musculus ED50 0.38 mg.kg-1 10.1016/0960-894X(96)00168-0
Mus musculus Mus musculus IC50 3.2 nM 10.1021/jm020375q
Mus musculus Mus musculus No. of cures 0.0 None 10.1021/jm0400092
Mus musculus Mus musculus Survival 40.8 day 10.1016/j.ejmech.2006.11.006
Mus musculus Mus musculus Survival 40.8 day 10.1021/jm0302602
Mus musculus Mus musculus Survival 40.8 day 10.1021/jm0400092
Mus musculus Mus musculus Survival 40.8 day 10.1021/jm058190h
Mus musculus Mus musculus Survival 42.75 day 10.1021/jm050177+
Mus musculus Mus musculus Survival 42.75 day 10.1021/jm060470p
Mus musculus Mus musculus Survival 60.0 day 10.1021/jm050177+
Mus musculus Mus musculus Survival nan None 10.1021/jm050177+
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Peritoneal macrophage CC50 8500.0 nM 10.1016/j.ejmech.2018.02.029
Mus musculus Peritoneal macrophage CC50 35700.0 nM 10.1016/j.ejmech.2019.03.032
Mus musculus Peritoneal macrophage LC50 17200.0 nM 10.1016/j.bmc.2019.05.026
Mus musculus Peritoneal macrophage LD50 8.5 umol/L 10.1016/j.ejmech.2018.01.046
Mus musculus RAW264.7 CC50 25500.0 nM 10.1016/j.bmcl.2013.09.062
Mus musculus RAW264.7 IC50 30000.0 nM 10.1021/jm301172v
Mus musculus RAW264.7 Survival 75.0 % 10.1016/j.ejmech.2012.03.003
Mus musculus RAW264.7 Survival 85.6 % 10.1016/j.bmc.2014.08.020
Mycobacterium intracellulare Mycobacterium intracellulare Activity nan None 10.1016/j.bmc.2006.10.006
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1021/np020592u
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1021/np0400095
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC nan None 10.1021/np0601399
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 9100.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 11050.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis IC50 23530.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 25000.0 nM 10.1128/aac.00803-09
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 50000.0 nM 10.1128/aac.00803-09
Naegleria gruberi Naegleria gruberi Inhibition 43.0 % 10.6019/CHEMBL4513101
Nakaseomyces glabratus Nakaseomyces glabratus IC50 nan None 10.1039/C2MD20143G
Nakaseomyces glabratus Nakaseomyces glabratus MIC 3.13 ug.mL-1 10.1016/j.bmc.2015.07.006
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Pichia kudriavzevii Pichia kudriavzevii IC50 nan None 10.1039/C2MD20143G
Pichia kudriavzevii Pichia kudriavzevii MIC 19.8 ug.mL-1 10.1016/j.bmc.2015.07.006
Plasmodium berghei Plasmodium berghei Activity nan None 10.1016/j.bmcl.2008.05.009
Plasmodium berghei Plasmodium berghei IC50 2942.0 nM 10.1016/j.bmcl.2011.02.100
Plasmodium falciparum Plasmodium falciparum EC50 66.2 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum EC50 68.7 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum IC50 0.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC50 2.9 ug.mL-1 10.1016/j.ejmech.2010.04.011
Plasmodium falciparum Plasmodium falciparum IC50 6.4 nM 10.1016/j.bmc.2010.11.047
Plasmodium falciparum Plasmodium falciparum IC50 15.0 nM 10.1021/jm030545e
Plasmodium falciparum Plasmodium falciparum IC50 27.0 nM 10.1021/jm301614w
Plasmodium falciparum Plasmodium falciparum IC50 34.6 nM 10.1021/jm058190h
Plasmodium falciparum Plasmodium falciparum IC50 45.0 nM 10.1021/jm030545e
Plasmodium falciparum Plasmodium falciparum IC50 46.0 nM 10.1016/j.bmc.2013.10.050
Plasmodium falciparum Plasmodium falciparum IC50 46.0 nM 10.1021/jm400508e
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.bmc.2009.07.080
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.bmc.2009.12.011
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.bmc.2010.03.058
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.bmc.2011.02.045
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.bmc.2013.08.006
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.ejmech.2009.03.014
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.ejmech.2011.09.047
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.ejmech.2013.06.033
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.ejmech.2014.06.022
Plasmodium falciparum Plasmodium falciparum IC50 46.4 nM 10.1016/j.ejmech.2021.113625
Plasmodium falciparum Plasmodium falciparum IC50 58.0 nM 10.1021/jm0708634
Plasmodium falciparum Plasmodium falciparum IC50 58.0 nM 10.1021/jm800918v
Plasmodium falciparum Plasmodium falciparum IC50 58.0 nM 10.1021/jm9006406
Plasmodium falciparum Plasmodium falciparum IC50 58.0 nM 10.1021/jm900805v
Plasmodium falciparum Plasmodium falciparum IC50 58.0 nM 10.1021/jm901178d
Plasmodium falciparum Plasmodium falciparum IC50 58.4 nM 10.1016/j.ejmech.2006.11.006
Plasmodium falciparum Plasmodium falciparum IC50 278.0 nM 10.1016/j.bmc.2007.05.034
Plasmodium falciparum Plasmodium falciparum IC50 12302687.71 nM 10.1016/j.ejmech.2010.09.012
Plasmodium falciparum Plasmodium falciparum IC50 56234132.52 nM 10.1016/j.ejmech.2010.09.012
Plasmodium falciparum Plasmodium falciparum IC50 nan nM 10.1021/jm0302602
Plasmodium falciparum Plasmodium falciparum IC50 nan nM 10.1021/jm0400092
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1007/s00044-011-9798-7
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2006.10.006
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1016/j.bmc.2009.10.042
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/jm060470p
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/jm100507q
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/jm900946n
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np010419i
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np020592u
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np030045o
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np030086k
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np030524n
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np0400095
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np0601399
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np2004825
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np800163u
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1021/np800653z
Plasmodium falciparum Plasmodium falciparum IC50 nan None 10.1039/C3MD00097D
Plasmodium falciparum Plasmodium falciparum IC90 6.5 ug.mL-1 10.1016/j.ejmech.2010.04.011
Pneumocystis carinii Pneumocystis carinii Activity 2.75 % 10.1016/j.ejmech.2007.03.009
Pneumocystis carinii Pneumocystis carinii Activity 5.31 uM 10.1016/0960-894X(96)00353-8
Pneumocystis carinii Pneumocystis carinii Activity 27.0 uM 10.1016/0960-894X(96)00353-8
Pneumocystis carinii Pneumocystis carinii Activity 67.78 % 10.1016/j.ejmech.2007.03.009
Pneumocystis carinii Pneumocystis carinii Change in No. of trophozoites x 10E-5 -3.98 None 10.1016/s0960-894x(01)00541-8
Pneumocystis carinii Pneumocystis carinii Control 3.06 % 10.1021/jm990237+
Pneumocystis carinii Pneumocystis carinii Control 3.66 % 10.1021/jm00006a009
Pneumocystis carinii Pneumocystis carinii Growth 0.0 % 10.1016/s0960-894x(01)00541-8
Pneumocystis carinii Pneumocystis carinii IC50 84.0 nM 10.1021/np100201p
Pneumocystis carinii Pneumocystis carinii IC50 500.0 nM 10.1007/s00044-005-0130-2
Pneumocystis carinii Pneumocystis carinii IC50 500.0 nM 10.1016/j.bmcl.2004.06.034
Pneumocystis carinii Pneumocystis carinii IC50 500.0 nM 10.1016/j.bmcl.2008.03.020
Pneumocystis carinii Pneumocystis carinii IC50 500.0 nM 10.1016/j.bmcl.2009.08.073
Pneumocystis carinii Pneumocystis carinii IC50 500.0 nM 10.1039/C7MD00445A
Pneumocystis carinii Pneumocystis carinii No. of dead animals 2.0 None 10.1021/jm00006a009
Pneumocystis carinii Pneumocystis carinii Of control 1.47 % 10.1021/jm9604484
Pneumocystis carinii Pneumocystis carinii Toxicity 2.0 None 10.1021/jm9604484
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 1212.0 nM None
Rattus norvegicus Alpha-1a adrenergic receptor Ki 491.0 nM None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 967.0 nM None
Rattus norvegicus Alpha-1b adrenergic receptor Ki 535.0 nM None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Glutamate NMDA receptor IC50 1310.0 nM 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor IC50 1740.0 nM 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor IC50 2590.0 nM 10.1016/s0960-894x(99)00184-5
Rattus norvegicus Glutamate NMDA receptor IC50 3050.0 nM 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor IC50 3060.0 nM 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor Increase in IC50 9.5 None 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor Increase in IC50 21.4 None 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor Increase in IC50 30.7 None 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.18 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.47 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.51 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.57 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.77 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.83 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor log(RatioIC50) 0.95 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor nH 0.93 None 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor nH 1.15 None 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor nH 1.17 None 10.1016/S0960-894X(97)00240-0
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 1.51 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 3.07 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 3.27 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 3.82 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 5.86 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 6.69 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glutamate NMDA receptor Ratio IC50 9.12 None 10.1016/j.bmcl.2015.08.017
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus L6 IC50 46.6 nM 10.1016/j.ejmech.2006.11.006
Rattus norvegicus L6 IC50 1510.0 nM 10.1021/jm301614w
Rattus norvegicus L6 IC50 2100.0 nM 10.1016/j.bmc.2009.07.080
Rattus norvegicus L6 IC50 2100.0 nM 10.1016/j.bmc.2013.08.006
Rattus norvegicus L6 IC50 2100.0 nM 10.1016/j.ejmech.2011.09.047
Rattus norvegicus L6 IC50 2100.0 nM 10.1021/jm060470p
Rattus norvegicus L6 IC50 3800.0 nM 10.1016/j.bmc.2010.02.034
Rattus norvegicus L6 IC50 6000.0 nM 10.1016/j.bmc.2010.11.047
Rattus norvegicus L6 IC50 25000.0 nM 10.1016/j.bmc.2010.11.003
Rattus norvegicus L6 IC50 31800.0 nM 10.1016/j.bmc.2016.04.006
Rattus norvegicus L6 IC50 46000.0 nM 10.1016/j.bmc.2009.12.011
Rattus norvegicus L6 IC50 46000.0 nM 10.1016/j.bmc.2011.02.045
Rattus norvegicus L6 IC50 46000.0 nM 10.1016/j.ejmech.2021.113625
Rattus norvegicus L6 IC50 46600.0 nM 10.1016/j.bmc.2010.03.058
Rattus norvegicus L6 IC50 46600.0 nM 10.1016/j.bmc.2013.10.050
Rattus norvegicus L6 IC50 46600.0 nM 10.1016/j.ejmech.2009.03.014
Rattus norvegicus L6 IC50 46600.0 nM 10.1016/j.ejmech.2014.06.022
Rattus norvegicus L6 IC50 46600.0 nM 10.1021/jm0708634
Rattus norvegicus L6 IC50 46600.0 nM 10.1021/jm400508e
Rattus norvegicus L6 IC50 46600.0 nM 10.1021/jm800918v
Rattus norvegicus L6 IC50 46600.0 nM 10.1021/jm9006406
Rattus norvegicus L6 IC50 46600.0 nM 10.1021/jm900805v
Rattus norvegicus L6 IC50 46600.0 nM 10.1021/jm901178d
Rattus norvegicus L6 IC50 46600000.0 nM 10.1016/j.ejmech.2013.06.033
Rattus norvegicus L6 TD50 1.5 uM 10.1021/jm058190h
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Protein S100-B Kd 44000.0 nM 10.1021/acs.jmedchem.5b01369
Rattus norvegicus Protein S100-B Kd 50000.0 nM 10.1021/acs.jmedchem.5b01369
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.ejmech.2007.03.009
Rattus norvegicus Rattus norvegicus ALB 41300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 45700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 46300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 288.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 303.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 331.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 364.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 393.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 396.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 42.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 44.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 54.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 68.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 71.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 79.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 84.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 92.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 136.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 180.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 186.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 190.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 195.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 570.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 671.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 675.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 696.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 753.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 766.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 246.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 265.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 308.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 325.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 346.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 378.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 26670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Control 0.61 % 10.1021/jm970570i
Rattus norvegicus Rattus norvegicus Control 1.46 % 10.1021/jm970570i
Rattus norvegicus Rattus norvegicus Control 1.82 % 10.1021/jm980230c
Rattus norvegicus Rattus norvegicus Control 2.3 % 10.1021/jm990071c
Rattus norvegicus Rattus norvegicus Control 4.5 % 10.1016/S0960-894X(00)80302-9
Rattus norvegicus Rattus norvegicus Control 4.95 % 10.1021/jm00052a014
Rattus norvegicus Rattus norvegicus Control 5.31 % 10.1021/jm00052a014
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Effectiveness 1.5 None 10.1021/jm00024a001
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 27.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 160.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 183.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 193.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1366.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1450.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1583.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1663.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1706.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1783.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.7 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.42 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 37.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 38.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 137800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 138000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 140300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 129.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 175.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 184.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 245.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 405.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 461.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.2 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12540.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13593.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13847.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14369.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15017.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 15717.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 85.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 86.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.07 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.08 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.57 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.7 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.9 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 368300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 375000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 375300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 376000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 376800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.53 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.6 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.63 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.27 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.63 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.37 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 234.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 361.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 389.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 444.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 485.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 576.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 3.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 11.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 972.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1031.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1759.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1795.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1836.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1883.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 109.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 116.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 123.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1186330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1241670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1352500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1425000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1444670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1455000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.78 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.06 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.46 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.48 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.64 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 62200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5680000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5860000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5880000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5980000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5990000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 6150000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.28 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.4 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Toxicity 2.0 None 10.1016/S0960-894X(00)80302-9
Rattus norvegicus Rattus norvegicus Toxicity 2.0 None 10.1021/jm00052a014
Rattus norvegicus Rattus norvegicus Toxicity nan None 10.1021/jm00024a001
Rattus norvegicus Rattus norvegicus Toxicity nan None 10.1021/jm990071c
Rattus norvegicus Rattus norvegicus Toxicity nan None 10.1021/jm990237+
Rattus norvegicus Rattus norvegicus URATE 13.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 16.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 19.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 19.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14530.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 15400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16030.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16430.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16830.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 18180.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 103000.0 nM 10.1021/acsmedchemlett.3c00035
Staphylococcus aureus Staphylococcus aureus EC50 4200.0 nM 10.1021/jm501449u
Staphylococcus aureus Staphylococcus aureus IC50 nan None 10.1016/j.bmc.2006.10.006
Sus scrofa Acrosin Ki 2300.0 nM 10.1021/jm00209a008
Sus scrofa LLC-PK1 IC50 nan None 10.1016/j.bmc.2006.10.006
Sus scrofa LLC-PK1 IC50 nan None 10.1039/C3MD00097D
Sus scrofa Tubulin IC50 nan None 10.1016/j.bmc.2007.06.042
Trichinella spiralis Trichinella spiralis Activity nan None 10.1016/j.ejmech.2010.03.050
Trichomonas vaginalis Trichomonas vaginalis IC50 3815.0 nM 10.1016/j.bmc.2014.01.029
Trichomonas vaginalis Trichomonas vaginalis IC50 3815.0 nM 10.1016/j.bmcl.2008.05.009
Trichomonas vaginalis Trichomonas vaginalis IC50 3815.0 nM 10.1016/j.bmcl.2011.02.100
Trichomonas vaginalis Trichomonas vaginalis IC50 3815.0 nM 10.1016/j.bmcl.2017.05.071
Trichomonas vaginalis Trichomonas vaginalis IC50 nan None 10.1016/j.ejmech.2010.03.050
Trypanosoma brucei Class 1 phosphodiesterase PDEB1 Inhibition nan % 10.1021/acs.jmedchem.7b01670
Trypanosoma brucei Trypanosoma brucei EC50 0.95 nM 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei EC50 1.1 nM 10.1021/jm301215e
Trypanosoma brucei Trypanosoma brucei EC50 1.6 nM 10.1016/j.ejmech.2018.01.043
Trypanosoma brucei Trypanosoma brucei EC50 1.7 nM 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei EC50 3.8 nM 10.1016/j.ejmech.2018.01.043
Trypanosoma brucei Trypanosoma brucei EC50 3.8 nM 10.1021/acs.jmedchem.8b02021
Trypanosoma brucei Trypanosoma brucei EC50 5.1 nM 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei EC50 5.7 nM 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei EC50 6.0 nM 10.1016/j.bmcl.2008.02.037
Trypanosoma brucei Trypanosoma brucei EC50 6.1 nM 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei EC50 8.0 nM 10.1016/j.bmc.2011.12.018
Trypanosoma brucei Trypanosoma brucei EC50 11.0 nM 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei EC50 12.0 nM 10.1016/j.bmcl.2023.129123
Trypanosoma brucei Trypanosoma brucei EC50 18.0 nM 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei EC50 18.0 nM 10.1016/j.ejmech.2019.112018
Trypanosoma brucei Trypanosoma brucei EC50 110.0 nM 10.1016/j.ejmech.2022.114876
Trypanosoma brucei Trypanosoma brucei EC50 140.0 nM 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei EC50 140.0 nM 10.1016/j.ejmech.2019.112018
Trypanosoma brucei Trypanosoma brucei EC50 938.0 nM 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei EC50 940.0 nM 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei Trypanosoma brucei EC50 990.0 nM 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei EC50 990.0 nM 10.1016/j.ejmech.2019.112018
Trypanosoma brucei Trypanosoma brucei EC50 1420.0 nM 10.1021/acsmedchemlett.8b00498
Trypanosoma brucei Trypanosoma brucei EC50 2600.0 nM 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei ED50 0.0002 ug ml-1 10.1016/s0960-894x(01)00528-5
Trypanosoma brucei Trypanosoma brucei ED50 0.006 uM 10.1021/jm000472o
Trypanosoma brucei Trypanosoma brucei ED50 0.008 uM 10.1016/s0960-894x(00)00608-9
Trypanosoma brucei Trypanosoma brucei ED50 0.01 ug ml-1 10.1016/s0960-894x(00)00154-2
Trypanosoma brucei Trypanosoma brucei IC50 0.002 ug.mL-1 10.1016/j.bmcl.2015.10.062
Trypanosoma brucei Trypanosoma brucei IC50 0.8 nM 10.1021/jm020375q
Trypanosoma brucei Trypanosoma brucei IC50 1.55 nM 10.1021/acsmedchemlett.8b00565
Trypanosoma brucei Trypanosoma brucei IC50 3.1 nM 10.1021/jm020375q
Trypanosoma brucei Trypanosoma brucei IC50 4.1 nM 10.1016/j.bmcl.2014.06.030
Trypanosoma brucei Trypanosoma brucei IC50 4.6 nM 10.1016/j.bmcl.2006.12.016
Trypanosoma brucei Trypanosoma brucei IC50 5.0 nM 10.1021/jm020375q
Trypanosoma brucei Trypanosoma brucei IC50 10.0 nM 10.1016/j.bmc.2018.06.033
Trypanosoma brucei Trypanosoma brucei IC50 11.0 nM 10.1016/j.bmcl.2014.11.073
Trypanosoma brucei Trypanosoma brucei IC50 12.0 nM 10.1016/j.bmc.2010.11.003
Trypanosoma brucei Trypanosoma brucei IC50 13.0 nM 10.1021/jm0304461
Trypanosoma brucei Trypanosoma brucei IC50 30.0 nM 10.1021/np300834q
Trypanosoma brucei Trypanosoma brucei IC50 35.0 nM 10.1021/jm0002578
Trypanosoma brucei Trypanosoma brucei IC50 2200.0 nM 10.1021/acsmedchemlett.1c00589
Trypanosoma brucei Trypanosoma brucei IC50 6430.0 nM 10.1016/j.bmcl.2014.02.046
Trypanosoma brucei Trypanosoma brucei IC90 0.003 ug.mL-1 10.1016/j.bmcl.2015.10.062
Trypanosoma brucei Trypanosoma brucei IC90 7.0 nM 10.1016/j.bmcl.2014.06.030
Trypanosoma brucei Trypanosoma brucei Inhibition 100.0 % 10.1016/s0960-894x(00)00196-7
Trypanosoma brucei Trypanosoma brucei Ratio EC50 0.89 None 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei Ratio EC50 1.06 None 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei Ratio EC50 1.8 None 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei Ratio EC50 2.0 None 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei Ratio EC50 3.0 None 10.1128/aac.00332-10
Trypanosoma brucei Trypanosoma brucei Ratio EC50 13.8 None 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei Ratio EC50 94.6 None 10.1016/j.ejmech.2018.12.050
Trypanosoma brucei Trypanosoma brucei Ratio EC50 164.0 None 10.1016/j.bmcl.2017.05.052
Trypanosoma brucei Trypanosoma brucei TIME 30.0 hr 10.1016/j.bmcl.2023.129123
Trypanosoma brucei brucei Trypanosoma brucei brucei Activity 58.1 % 10.1021/jm500191u
Trypanosoma brucei brucei Trypanosoma brucei brucei Activity 100.0 % 10.1016/j.bmcl.2017.10.067
Trypanosoma brucei brucei Trypanosoma brucei brucei Activity 100.0 % 10.1021/jm500191u
Trypanosoma brucei brucei Trypanosoma brucei brucei Activity nan None 10.1016/j.bmc.2014.12.066
Trypanosoma brucei brucei Trypanosoma brucei brucei Activity nan None 10.1128/aac.01674-08
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 0.11 nM 10.1016/j.ejmech.2015.07.013
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1.4 nM 10.1021/ml200160k
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1.4 ug.mL-1 10.1021/np2004825
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1.55 nM 10.1016/j.ejmech.2016.12.017
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1.55 nM 10.1021/acs.jmedchem.6b00698
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1.7 nM 10.1039/d0md00057d
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1.9 nM 10.1021/acs.jmedchem.2c00232
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 2.1 nM 10.1016/j.bmc.2016.11.019
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 2.16 nM 10.1021/acsmedchemlett.7b00202
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 2.8 nM 10.1021/acs.jmedchem.6b01740
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 3.2 nM 10.1021/ml200160k
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 3.3 nM 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 3.5 nM 10.1021/jm400349k
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 4.0 nM 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 4.0 nM 10.1021/acs.jmedchem.6b01740
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 4.0 nM 10.1021/acsmedchemlett.1c00717
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 4.2 nM 10.1021/acsmedchemlett.8b00282
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 4.9 nM 10.1016/j.ejmech.2021.113470
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 6.0 nM 10.1021/ml500408d
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 8.0 nM 10.1021/jm2014259
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 9.0 nM 10.1021/jm2014259
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 10.0 nM 10.1021/ml500408d
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 11.0 nM 10.1016/j.ejmech.2019.112018
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 12.0 nM 10.1021/jm301687p
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 26.0 nM 10.1021/acs.jmedchem.1c01151
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 34.0 nM 10.1016/j.ejmech.2021.113470
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 46.0 nM 10.1021/acsmedchemlett.1c00717
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 47.0 nM 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 64.0 nM 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 66.0 nM 10.1021/ml200160k
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 208.0 nM 10.1021/acsmedchemlett.1c00717
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 329.0 nM 10.1021/ml500408d
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 500.0 nM 10.1016/j.ejmech.2021.113470
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 550.0 nM 10.1016/j.ejmech.2015.07.013
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 567.0 nM 10.1021/jm2014259
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 670.0 nM 10.1016/j.ejmech.2009.11.035
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 940.0 nM 10.1021/acs.jmedchem.6b01740
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 1740.0 nM 10.1021/jm401178t
Trypanosoma brucei brucei Trypanosoma brucei brucei EC90 0.00613 uM 10.1021/acsmedchemlett.7b00202
Trypanosoma brucei brucei Trypanosoma brucei brucei GI nan None 10.1016/j.bmc.2016.11.019
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.0 nM 10.1016/j.bmc.2010.01.068
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.0006 ug.mL-1 10.1021/np010419i
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.0006 ug.mL-1 10.1021/np020362f
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.0009 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.00158 ug.mL-1 10.1016/j.bmc.2008.10.061
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.0017 ug.mL-1 10.1016/j.bmcl.2013.12.052
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.0041 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.007 ug.mL-1 10.1021/np049682k
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.009 ug.mL-1 10.1016/j.ejmech.2021.113319
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 0.014 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1.4 nM 10.1016/j.ejmech.2019.04.052
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1.6 nM 10.1021/acs.jmedchem.5b00687
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 1.995 nM 10.1021/acs.jmedchem.8b01578
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2.0 nM 10.1016/j.bmcl.2009.08.073
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2.0 nM 10.1021/acs.jmedchem.0c01372
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2.0 nM 10.1021/acs.jmedchem.8b01578
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2.13 nM 10.1039/d0md00277a
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2.5 nM 10.1021/np0702281
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 2.9 nM 10.1021/jm900629w
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3.0 nM 10.1016/j.ejmech.2010.08.062
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3.1 nM 10.1039/C8MD00319J
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3.2 nM 10.1016/j.bmcl.2012.09.091
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 3.2 nM 10.1016/j.ejmech.2013.05.044
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 4.051 nM 10.1021/acsmedchemlett.2c00170
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 5.0 nM 10.1016/j.ejmech.2013.04.066
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 5.0 nM 10.1016/j.ejmech.2016.11.043
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 5.3 nM 10.1016/j.bmc.2017.06.051
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 7.0 nM 10.1016/j.bmc.2010.02.034
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 7.0 nM 10.1016/j.bmcl.2010.05.091
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 10.0 nM 10.1016/j.ejmech.2021.113913
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 11.0 nM 10.1016/j.ejmech.2015.12.045
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 11.0 nM 10.1039/C2MD20197F
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 11.0 nM 10.1039/C3MD00065F
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 14.0 nM 10.1039/d0md00058b
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 26.0 nM 10.1016/j.ejmech.2014.04.079
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 26.0 nM 10.1016/j.ejmech.2019.111827
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 26.0 nM 10.1016/j.ejmech.2021.113319
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 26.0 nM 10.1021/jm101225g
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 39.0 nM 10.1016/j.bmcl.2019.126911
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 50.0 nM 10.1016/j.ejmech.2014.05.037
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 15100.0 nM 10.1016/j.bmc.2011.06.006
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1016/j.bmc.2007.06.042
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1016/j.bmc.2011.01.010
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 nan None 10.1021/np0502600
Trypanosoma brucei brucei Trypanosoma brucei brucei IC90 nan None 10.1021/acsmedchemlett.2c00170
Trypanosoma brucei brucei Trypanosoma brucei brucei Inhibition nan % 10.1021/acs.jmedchem.2c00232
Trypanosoma brucei brucei Trypanosoma brucei brucei MEC 5.0 uM 10.1016/j.ejmech.2012.03.003
Trypanosoma brucei brucei Trypanosoma brucei brucei MEC 5.0 uM 10.1016/j.ejmech.2013.06.002
Trypanosoma brucei brucei Trypanosoma brucei brucei MSD 30.0 day 10.1016/j.bmcl.2017.10.067
Trypanosoma brucei brucei Trypanosoma brucei brucei MST 35.0 day 10.1128/aac.00076-09
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 0.6 None 10.1021/ml500408d
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 1.1 None 10.1021/jm2014259
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 1.14 None 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 1.32 None 10.1021/acs.jmedchem.6b01740
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 14.1 None 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 19.2 None 10.1016/j.ejmech.2018.02.075
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 32.9 None 10.1021/ml500408d
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 70.9 None 10.1021/jm2014259
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio EC50 3349.0 None 10.1016/j.ejmech.2015.07.013
Trypanosoma brucei brucei Trypanosoma brucei brucei Ratio IC50 4.3 None 10.1128/aac.00225-09
Trypanosoma brucei brucei Trypanosoma brucei brucei Survival 40.0 day 10.1128/aac.01674-08
Trypanosoma brucei gambiense Trypanosoma brucei gambiense EC50 0.7 nM 10.1021/jm301687p
Trypanosoma brucei gambiense Trypanosoma brucei gambiense EC50 0.9 nM 10.1021/jm301687p
Trypanosoma brucei gambiense Trypanosoma brucei gambiense EC50 51.0 nM 10.1021/jm301687p
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 0.0011 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 0.0042 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 0.0049 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 0.0155 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 1.0 nM 10.1039/C8MD00425K
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 1.5 nM 10.1016/j.ejmech.2019.04.052
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 4.9 nM 10.1016/j.bmc.2015.03.029
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 5.2 nM 10.1016/j.bmcl.2012.09.091
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 5.3 nM 10.1016/j.ejmech.2013.05.044
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 7.0 nM 10.1016/j.ejmech.2015.01.012
Trypanosoma brucei gambiense Trypanosoma brucei gambiense IC50 11.0 nM 10.1016/j.bmc.2013.07.002
Trypanosoma brucei rhodesiense Rhodesain IC50 nan None 10.1016/j.bmc.2010.02.034
Trypanosoma brucei rhodesiense Rhodesain Inhibition 28.0 % 10.1021/jm900629w
Trypanosoma brucei rhodesiense Rhodesain Inhibition nan % 10.1021/jm900629w
Trypanosoma brucei rhodesiense Rhodesain Ki nan None 10.1021/jm900629w
Trypanosoma brucei rhodesiense Rhodesain Ki nan None 10.1021/jm900946n
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity 20.0 day 10.1021/jm901178d
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity 24.0 day 10.1016/j.bmc.2011.02.045
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity 26.0 day 10.1021/jm901178d
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity nan None 10.1016/j.bmc.2010.11.003
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity nan None 10.1016/j.ejmech.2006.11.006
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity nan None 10.1016/j.ejmech.2009.03.014
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity nan None 10.1021/jm00214a014
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Activity nan None 10.1128/aac.00076-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense EC50 0.6 nM 10.1021/jm301687p
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense ED50 0.001 uM 10.1021/jm060290f
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense ED50 0.1 nM 10.1021/jm0504860
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.0005 ug.mL-1 10.1021/np020362f
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.0012 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.0017 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.004 ug.mL-1 10.1021/np020362f
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.0099 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.11 ug.mL-1 10.1021/acs.jnatprod.1c00738
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.1245 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.1336 ug.mL-1 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 0.4 ug.mL-1 10.1021/np800711a
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 1.0 nM 10.1021/acs.jnatprod.0c01209
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 1.3 nM 10.1016/j.bmc.2010.11.003
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.0 nM 10.1016/j.bmcl.2009.08.073
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.0 nM 10.1021/jm301614w
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.bmc.2009.07.080
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.bmc.2009.12.011
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.bmc.2010.11.047
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.bmc.2011.02.045
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.bmc.2013.08.006
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.ejmech.2011.09.047
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1016/j.ejmech.2021.113625
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1021/jm0302602
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1021/jm0400092
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.2 nM 10.1021/jm060470p
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.3 nM 10.1016/j.ejmech.2014.06.022
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.3 nM 10.1021/jm058190h
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.8 nM 10.1016/j.bmc.2010.03.058
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.8 nM 10.1016/j.ejmech.2006.11.006
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2.8 nM 10.1016/j.ejmech.2009.03.014
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1016/j.bmc.2013.10.050
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1016/j.ejmech.2013.06.033
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1021/jm0708634
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1021/jm400508e
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1021/jm800918v
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1021/jm9006406
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1021/jm900805v
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 3.0 nM 10.1021/jm901178d
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 5.0 nM 10.1021/acs.jnatprod.1c00792
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 7.07 nM 10.1016/j.ejmech.2021.113861
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 9.0 nM 10.1021/acs.jmedchem.7b01870
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 10.0 nM 10.6019/CHEMBL3392926
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 11.0 nM 10.1016/j.bmcl.2005.11.060
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 11.0 nM 10.1016/j.ejmech.2017.01.027
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 50.0 nM 10.1016/j.bmcl.2008.03.020
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 1200.0 nM 10.1128/aac.01544-06
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC50 2800.0 nM 10.1016/j.bmc.2016.04.006
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense IC90 3700.0 nM 10.1128/aac.01544-06
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MSD 38.0 day 10.1016/j.bmc.2013.10.050
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MSD 38.0 day 10.1016/j.ejmech.2013.06.033
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MSD 38.0 day 10.1021/jm400508e
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MSD 45.0 day 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MSD 57.5 day 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MST 4.0 day 10.1021/jm00219a023
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MST 5.0 day 10.1021/jm00219a023
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MST 11.6 day 10.1128/aac.00076-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense MST 18.0 day 10.1128/aac.00076-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Ratio IC50 105.4 None 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Ratio IC50 113.1 None 10.1128/aac.00225-09
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 38.0 day 10.1016/j.bmc.2009.07.080
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 38.0 day 10.1016/j.bmc.2013.08.006
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 42.8 day 10.1016/j.ejmech.2009.03.014
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 45.0 day 10.1016/j.bmc.2010.03.058
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 45.0 day 10.1016/j.bmc.2010.11.047
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 45.0 day 10.1021/jm800918v
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 45.0 day 10.1021/jm900805v
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 57.5 day 10.1016/j.bmc.2009.07.080
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 57.5 day 10.1016/j.bmc.2013.08.006
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 57.5 day 10.1021/jm800918v
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense Survival 57.5 day 10.1021/jm900805v
Trypanosoma brucei rhodesiense Trypanosoma brucei rhodesiense TIME 480.0 hr 10.1016/j.ejmech.2021.113625
Trypanosoma congolense Trypanosoma congolense EC50 1900.0 nM 10.1016/j.ejmech.2018.12.050
Trypanosoma congolense Trypanosoma congolense EC50 nan None 10.1021/acs.jmedchem.6b01740
Trypanosoma cruzi Trypanosoma cruzi Activity nan None 10.1021/np000527p
Trypanosoma cruzi Trypanosoma cruzi EC50 nan None 10.1016/j.bmcl.2015.05.072
Trypanosoma cruzi Trypanosoma cruzi EC50 nan None 10.1016/j.ejmech.2018.01.043
Trypanosoma cruzi Trypanosoma cruzi EC50 nan None 10.1021/acs.jmedchem.1c01151
Trypanosoma cruzi Trypanosoma cruzi ED50 4.2 uM 10.1021/jm0504860
Trypanosoma cruzi Trypanosoma cruzi ED50 nan None 10.1016/s0960-894x(00)00154-2
Trypanosoma cruzi Trypanosoma cruzi IC50 2.4 nM 10.1128/aac.00425-07
Trypanosoma cruzi Trypanosoma cruzi IC50 5.35 nM 10.1016/j.ejmech.2006.11.006
Trypanosoma cruzi Trypanosoma cruzi IC50 6.0 nM 10.1128/aac.00425-07
Trypanosoma cruzi Trypanosoma cruzi IC50 1100.0 nM 10.1128/aac.01544-06
Trypanosoma cruzi Trypanosoma cruzi IC50 4440.0 nM 10.6019/CHEMBL3392926
Trypanosoma cruzi Trypanosoma cruzi IC50 4580.0 nM 10.1016/j.bmcl.2014.02.046
Trypanosoma cruzi Trypanosoma cruzi IC50 7100.0 nM 10.1016/j.ejmech.2014.06.022
Trypanosoma cruzi Trypanosoma cruzi IC50 7100.0 nM 10.1016/s0960-894x(03)00319-6
Trypanosoma cruzi Trypanosoma cruzi IC50 50000.0 nM 10.1016/j.bmc.2014.01.029
Trypanosoma cruzi Trypanosoma cruzi IC50 50000.0 nM 10.1016/j.bmcl.2011.02.100
Trypanosoma cruzi Trypanosoma cruzi IC50 50000.0 nM 10.1016/j.bmcl.2017.05.071
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1016/j.bmc.2010.09.015
Trypanosoma cruzi Trypanosoma cruzi IC50 nan None 10.1021/np300077r
Trypanosoma cruzi Trypanosoma cruzi IC90 4400.0 nM 10.1128/aac.01544-06
Trypanosoma cruzi Trypanosoma cruzi Inhibition 100.0 % 10.1021/np9800654
Trypanosoma cruzi Trypanosoma cruzi Ratio IC50 2.5 None 10.1128/aac.00425-07
Trypanosoma cruzi Trypanothione reductase Inhibition nan % 10.1016/s0960-894x(00)00154-2
Trypanosoma evansi Trypanosoma evansi IC50 0.00033 ug.mL-1 10.1021/acs.jnatprod.1c00738
None ADMET Activity 31.0 % 10.1016/j.bmcl.2011.09.134
None ADMET Activity 90.0 ug ml-1 10.1007/s00044-012-0355-9
None ADMET Activity 90.0 ug ml-1 10.1016/j.ejmech.2008.04.014
None ADMET Activity 100.0 % 10.1016/j.ejmech.2013.06.040
None ADMET Activity nan None 10.1016/j.bmc.2010.09.015
None ADMET Activity nan None 10.1021/np0705256
None ADMET CC50 3.82 ug.mL-1 10.1016/j.bmc.2013.03.045
None ADMET CC50 560.0 nM 10.1016/j.ejmech.2014.05.037
None ADMET CC50 560.0 nM 10.1016/j.ejmech.2014.07.113
None ADMET CC50 1000.0 nM 10.1016/j.bmc.2013.09.002
None ADMET CC50 11220.0 nM 10.1016/j.ejmech.2015.06.005
None ADMET CC50 26300.0 nM 10.1016/j.ejmech.2013.06.002
None ADMET CC50 35700.0 nM 10.1016/j.bmcl.2015.06.085
None ADMET CL 74.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Drug metabolism 82.0 % 10.1016/j.bmcl.2019.06.045
None ADMET EC50 35690.0 nM 10.1016/j.bmcl.2015.05.072
None ADMET IC50 8.7 ug.mL-1 10.1021/np0705256
None ADMET IC50 560.0 nM 10.1021/jm00126a021
None ADMET IC50 1000.0 nM 10.1016/j.bmc.2015.03.064
None ADMET IC50 30400.0 nM 10.1021/jm301172v
None ADMET IC50 152700.0 nM 10.1016/j.ejmech.2015.09.002
None ADMET IC50 nan None 10.1016/j.ejmech.2015.09.002
None ADMET IC50 nan None 10.1021/np100201p
None ADMET IC50 nan None 10.1021/np300077r
None ADMET Imax 1.1 uM 10.1021/jm00126a021
None ADMET LD50 8.5 uM 10.1016/j.ejmech.2015.09.009
None ADMET log10(%HIA +10) 1.0 None 10.1016/j.ejmech.2010.11.005
None ADMET MRT 12.0 hr 10.1124/dmd.108.020479
None ADMET Ratio CC50/EC50 5263.0 None 10.1021/acs.jmedchem.2c00232
None ADMET Ratio CC50/IC50 4.7 None 10.1016/j.ejmech.2019.03.032
None ADMET Ratio CC50/IC50 7.0 None 10.1016/j.ejmech.2019.03.032
None ADMET Ratio CC50/IC50 5000.0 None 10.1021/acsmedchemlett.1c00589
None ADMET Ratio CC50/IC50 12786.0 None 10.1021/acsmedchemlett.2c00170
None ADMET Ratio CC50/IC50 nan None 10.1021/acsmedchemlett.2c00170
None ADMET Ratio IC50 0.6 None 10.1021/jm301172v
None ADMET Ratio IC50 1.0 None 10.1021/jm301172v
None ADMET Ratio IC50 2.2 None 10.1021/jm301172v
None ADMET Ratio IC50 5.7 None 10.1021/jm301172v
None ADMET Ratio IC50 33.2 None 10.1016/j.ejmech.2015.09.002
None ADMET Ratio IC50 50.9 None 10.1016/j.ejmech.2015.09.002
None ADMET Ratio IC50 nan None 10.1016/j.ejmech.2015.09.002
None ADMET Retention_time 25.1 min 10.1016/j.bmcl.2019.06.045
None ADMET Selectivity Index 20.0 None 10.1016/j.ejmech.2021.113625
None ADMET Selectivity Index 991.0 None 10.1016/j.ejmech.2021.113625
None ADMET T1/2 25.0 hr 10.1124/dmd.108.020479
None ADMET TD50 2.21 uM 10.1016/j.ejmech.2006.12.026
None ADMET Toxicity 0.0 None 10.1021/jm970570i
None ADMET Toxicity nan None 10.1021/jm970570i
None ADMET Vdss 53.0 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 11.5 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 0.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 5.7 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 5.7 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 5.7 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Molecular identity unknown IC50 4200.0 nM 10.1016/s0960-894x(03)00319-6
None NON-PROTEIN TARGET EC50 0.9 nM 10.1016/j.ejmech.2016.10.024
None NON-PROTEIN TARGET EC50 19.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET EC50 822.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 1350.0 nM 10.1016/j.bmcl.2003.11.055
None NON-PROTEIN TARGET EC50 1995.0 nM 10.1038/nchembio873
None NON-PROTEIN TARGET EC50 16300.0 nM 10.1021/acs.jmedchem.5b01369
None NON-PROTEIN TARGET EC50 16700.0 nM 10.1021/acs.jmedchem.5b01369
None NON-PROTEIN TARGET EC50 19000.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET EC50 100000.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 17.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 43.5 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 2.1 nM 10.1016/j.bmc.2016.10.013
None NON-PROTEIN TARGET IC50 1200.0 nM 10.1016/j.bmc.2014.02.049
None NON-PROTEIN TARGET IC50 1200.0 nM 10.1021/jm0497038
None NON-PROTEIN TARGET IC50 7780.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 8870.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 29370.0 nM 10.6019/CHEMBL3392926
None NON-PROTEIN TARGET IC50 63000.0 nM 10.1016/j.bmcl.2016.09.051
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.bmc.2016.10.013
None NON-PROTEIN TARGET IC50 nan None 10.1021/np100201p
None NON-PROTEIN TARGET MIC nan ug.mL-1 10.1016/s0960-894x(00)00154-2
None NON-PROTEIN TARGET Ratio IC50 11.4 None 10.1016/j.ejmech.2013.04.066
None NON-PROTEIN TARGET Ratio IC50 24.84 None 10.1016/j.bmcl.2014.02.046
None NON-PROTEIN TARGET Ratio IC50 34.87 None 10.1016/j.bmcl.2014.02.046
None No relevant target IC50 nan None 10.1016/j.bmcl.2015.12.085
None No relevant target LogP 1.49 None 10.1039/C7MD00008A
None No relevant target Retention_time 25.4 min 10.1016/j.bmcl.2019.06.045
None Nucleic Acid Activity nan None 10.1021/jm060295c
None Nucleic Acid Change in Tm 11.1 degrees C 10.1016/s0960-894x(01)00541-8
None Nucleic Acid Delta Tm 0.0 None 10.1021/jm9507946
None Nucleic Acid Delta Tm 0.6 None 10.1021/jm00081a003
None Nucleic Acid Delta Tm 2.0 None 10.1021/jm0302602
None Nucleic Acid Delta Tm 2.3 None 10.1021/jm00081a003
None Nucleic Acid Delta Tm 3.2 None 10.1021/jm00081a003
None Nucleic Acid Delta Tm 4.65 degrees C 10.1016/j.ejmech.2010.01.047
None Nucleic Acid Delta Tm 4.8 None 10.1016/s0960-894x(03)00319-6
None Nucleic Acid Delta Tm 4.8 None 10.1021/jm9507946
None Nucleic Acid Delta Tm 6.58 degrees C 10.1016/j.ejmech.2010.01.047
None Nucleic Acid Delta Tm 10.0 None 10.1016/0960-894X(96)00353-8
None Nucleic Acid Delta Tm 12.6 degrees C 10.1016/j.bmc.2009.07.080
None Nucleic Acid Delta Tm 12.6 degrees C 10.1016/j.bmc.2010.03.058
None Nucleic Acid Delta Tm 12.6 degrees C 10.1016/j.bmc.2010.11.047
None Nucleic Acid Delta Tm 12.6 degrees C 10.1016/j.ejmech.2011.09.047
None Nucleic Acid Delta Tm 12.6 degrees C 10.1021/jm058190h
None Nucleic Acid Delta Tm 12.6 None 10.1021/jm0302602
None Nucleic Acid Delta Tm 12.6 None 10.1021/jm0400092
None Nucleic Acid Delta Tm 12.6 None 10.1021/jm990071c
None Nucleic Acid Delta Tm 12.8 None 10.1016/s0960-894x(03)00319-6
None Nucleic Acid Delta Tm 12.8 None 10.1021/jm9507946
None Nucleic Acid Delta Tm 20.6 degrees C 10.1021/jm030545e
None Nucleic Acid Delta Tm 21.6 degrees C 10.1016/j.bmcl.2009.08.073
None Nucleic Acid Delta Tm 22.9 None 10.1021/jm00081a003
None Nucleic Acid DNA binding 20.6 degrees C 10.1021/jm020375q
None Nucleic Acid K 2300000.0 None 10.1021/jm9507946
None Nucleic Acid Ratio 6.0 None 10.1021/jm00064a008
None Nucleic Acid Tm 3.2 degrees C 10.1021/jm00064a008
None Nucleic Acid Tm 20.2 degrees C 10.1021/jm00064a008
None Nucleic Acid Tm 22.9 degrees C 10.1021/jm00064a008
None Poly(dA-dT)oligonucleotide Delta Tm 12.6 degrees C 10.1016/j.bmc.2009.12.011
None Poly(dA-dT)oligonucleotide Delta Tm 12.6 degrees C 10.1016/j.bmc.2011.02.045
None Poly(dA-dT)oligonucleotide Delta Tm 12.6 degrees C 10.1016/j.ejmech.2021.113625
None Unchecked Change in Tm 20.6 degrees C 10.1016/s0960-894x(01)00541-8
None Unchecked Delta Tm 1.0 degrees C 10.1021/ml300166s
None Unchecked Delta Tm 2.7 degrees C 10.1021/jm501449u
None Unchecked Delta Tm 4.8 None 10.1021/jm9604484
None Unchecked Delta Tm 4.8 None 10.1021/jm990071c
None Unchecked Delta Tm 11.1 degrees C 10.1021/jm301614w
None Unchecked Delta Tm 12.6 degrees C 10.1016/j.bmc.2013.08.006
None Unchecked Delta Tm 12.8 degrees C 10.1021/jm301614w
None Unchecked Delta Tm 20.6 degrees C 10.1007/s00044-005-0130-2
None Unchecked Delta Tm 22.9 None 10.1016/0960-894X(96)00353-8
None Unchecked Delta Tm 32.3 degrees C 10.1021/jm7013088
None Unchecked Hepatotoxicity (acute) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 242.0 nM None
None Unchecked IC50 1391.0 nM None
None Unchecked IC50 2208.0 nM None
None Unchecked IC50 3524.0 nM None
None Unchecked IC50 9100.0 nM 10.1016/j.ejmech.2021.113210
None Unchecked IC50 23200.0 nM 10.1016/j.ejmech.2019.04.052
None Unchecked IC50 33800.0 nM 10.1039/C7MD00445A
None Unchecked IC50 38000.0 nM 10.1016/j.bmc.2014.02.049
None Unchecked IC50 46000.0 nM 10.1016/j.bmc.2011.09.025
None Unchecked IC50 240000.0 nM 10.1021/jm501449u
None Unchecked IC50 400000.0 nM 10.1021/jm501449u
None Unchecked IC50 1000000.0 nM 10.1016/j.bmc.2014.02.049
None Unchecked IC50 nan None 10.1016/j.bmc.2007.06.042
None Unchecked IC50 nan None 10.1016/j.bmc.2010.02.034
None Unchecked IC50 nan None 10.1016/j.ejmech.2015.06.005
None Unchecked IC50 nan None None
None Unchecked IFI 2.614 % 10.1073/pnas.0802982105
None Unchecked Inhibition 10.8 % 10.1016/j.bmc.2014.02.049
None Unchecked Inhibition 48.2 % 10.1016/j.bmc.2014.02.049
None Unchecked Inhibition nan % 10.1016/S0960-894X(97)00086-3
None Unchecked Kd 120.0 nM 10.1016/j.bmcl.2022.129113
None Unchecked Kd 130.0 nM 10.1021/ml300166s
None Unchecked Kd 40000.0 nM 10.1021/ml300166s
None Unchecked Ki 36.0 nM 10.1021/jm2014259
None Unchecked Ki 61.0 nM None
None Unchecked Ki 1352.0 nM None
None Unchecked Ki 1963.0 nM None
None Unchecked Ki 2349.0 nM None
None Unchecked Ki 7600.0 nM 10.1016/j.bmc.2014.02.049
None Unchecked Ki 56200.0 nM 10.1021/jm2014259
None Unchecked Ki nan None 10.1021/jm900946n
None Unchecked Ki nan None None
None Unchecked Potency 23109.3 nM None
None Unchecked Ratio 0.08 None 10.1021/jm301302s
None Unchecked Ratio 0.11 None 10.1021/jm301302s
None Unchecked Ratio 0.55 None 10.1021/jm301302s
None Unchecked Ratio CC50/EC50 6440.0 None 10.1021/acs.jmedchem.6b00698
None Unchecked Ratio CC50/IC50 0.1 None 10.1016/j.bmc.2013.09.002
None Unchecked Ratio CC50/IC50 0.1 None 10.1016/j.ejmech.2014.05.037
None Unchecked Ratio CC50/IC50 0.1 None 10.1016/j.ejmech.2014.07.113
None Unchecked Ratio CC50/IC50 0.17 None 10.1016/j.ejmech.2012.04.029
None Unchecked Ratio CC50/IC50 0.2 None 10.1016/j.ejmech.2014.05.037
None Unchecked Ratio CC50/IC50 0.38 None 10.1016/j.ejmech.2012.04.029
None Unchecked Ratio CC50/IC50 0.4 None 10.1016/j.bmc.2013.09.002
None Unchecked Ratio CC50/IC50 0.4 None 10.1016/j.bmc.2015.03.064
None Unchecked Ratio CC50/IC50 0.4 None 10.1016/j.ejmech.2014.05.037
None Unchecked Ratio CC50/IC50 0.4 None 10.1016/j.ejmech.2014.12.056
None Unchecked Ratio CC50/IC50 0.4 None 10.1021/acsmedchemlett.8b00347
None Unchecked Ratio CC50/IC50 0.5 None 10.1016/j.ejmech.2014.05.037
None Unchecked Ratio CC50/IC50 1.0 None 10.1016/j.ejmech.2014.05.037
None Unchecked Ratio CC50/IC50 1.08 None 10.1016/j.ejmech.2010.02.018
None Unchecked Ratio CC50/IC50 1.5 None 10.1016/j.ejmech.2018.02.029
None Unchecked Ratio CC50/IC50 1.69 None 10.1016/j.ejmech.2015.06.005
None Unchecked Ratio CC50/IC50 1.96 None 10.1016/j.bmcl.2013.09.062
None Unchecked Ratio CC50/IC50 2.07 None 10.1016/j.bmcl.2009.03.020
None Unchecked Ratio CC50/IC50 2.07 None 10.1016/j.ejmech.2010.04.004
None Unchecked Ratio CC50/IC50 2.58 None 10.1016/j.bmcl.2008.11.094
None Unchecked Ratio CC50/IC50 2.58 None 10.1016/j.bmcl.2009.10.117
None Unchecked Ratio CC50/IC50 2.58 None 10.1016/j.bmcl.2012.10.101
None Unchecked Ratio CC50/IC50 2.58 None 10.1016/j.ejmech.2009.01.016
None Unchecked Ratio CC50/IC50 2.58 None 10.1016/j.ejmech.2010.02.015
None Unchecked Ratio CC50/IC50 3.2 None 10.1016/j.bmcl.2017.05.071
None Unchecked Ratio CC50/IC50 5.3 None 10.1016/j.bmcl.2015.06.085
None Unchecked Ratio CC50/IC50 6.27 None 10.1021/ml400317e
None Unchecked Ratio CC50/IC50 8.68 None 10.1016/j.bmc.2013.03.045
None Unchecked Ratio CC50/IC50 11.0 None 10.1016/j.bmcl.2017.05.071
None Unchecked Ratio CC50/IC50 12.3 None 10.1016/j.bmcl.2017.05.071
None Unchecked Ratio CC50/IC50 46.0 None 10.1016/j.ejmech.2014.05.037
None Unchecked Ratio EC50 0.53 None 10.1016/j.bmcl.2015.05.072
None Unchecked Ratio EC50 1.8 None 10.1016/j.ejmech.2019.112018
None Unchecked Ratio EC50 1.81 None 10.1016/j.bmcl.2015.05.072
None Unchecked Ratio EC50 2.0 None 10.1021/jm301215e
None Unchecked Ratio EC50 2.43 None 10.1038/nchembio873
None Unchecked Ratio EC50 3.5 None 10.1016/j.bmcl.2015.05.072
None Unchecked Ratio EC50 5.71 None 10.1016/j.bmcl.2015.05.072
None Unchecked Ratio EC50 6.9 None 10.1016/j.ejmech.2021.113470
None Unchecked Ratio EC50 10.8 None 10.1021/acsmedchemlett.1c00717
None Unchecked Ratio EC50 13.8 None 10.1016/j.ejmech.2019.112018
None Unchecked Ratio EC50 49.5 None 10.1021/acsmedchemlett.1c00717
None Unchecked Ratio EC50 94.6 None 10.1016/j.ejmech.2019.112018
None Unchecked Ratio EC50 98.0 None 10.1021/acs.jmedchem.6b01740
None Unchecked Ratio EC50 102.0 None 10.1016/j.ejmech.2021.113470
None Unchecked Ratio EC50 285.0 None 10.1016/j.ejmech.2018.02.075
None Unchecked Ratio EC50 nan None 10.1016/j.bmcl.2015.05.072
None Unchecked Ratio IC50 0.05 None 10.1016/j.bmc.2009.07.080
None Unchecked Ratio IC50 0.05 None 10.1016/j.ejmech.2011.09.047
None Unchecked Ratio IC50 0.05 None 10.1021/jm0708634
None Unchecked Ratio IC50 0.16 None 10.1016/j.ejmech.2011.04.026
None Unchecked Ratio IC50 0.9 None 10.1128/aac.00225-09
None Unchecked Ratio IC50 1.1 None 10.1016/j.ejmech.2016.12.019
None Unchecked Ratio IC50 3.13 None 10.1016/j.ejmech.2012.10.048
None Unchecked Ratio IC50 3.6 None 10.1128/aac.00225-09
None Unchecked Ratio IC50 6.53 None 10.1016/j.ejmech.2014.06.022
None Unchecked Ratio IC50 13.1 None 10.1128/aac.00225-09
None Unchecked Ratio IC50 25.0 None 10.1016/j.ejmech.2013.06.033
None Unchecked Ratio IC50 25.0 None 10.1021/jm0708634
None Unchecked Ratio IC50 25.0 None 10.1021/jm800918v
None Unchecked Ratio IC50 25.0 None 10.1021/jm9006406
None Unchecked Ratio IC50 25.0 None 10.1021/jm900805v
None Unchecked Ratio IC50 25.0 None 10.1021/jm901178d
None Unchecked Ratio IC50 25.4 None 10.1016/j.ejmech.2009.03.014
None Unchecked Ratio IC50 48.0 None 10.1016/j.bmcl.2009.08.073
None Unchecked Ratio IC50 55.9 None 10.1016/j.ejmech.2014.06.022
None Unchecked Ratio IC50 56.0 None 10.1021/jm301614w
None Unchecked Ratio IC50 307.0 None 10.1039/d0md00277a
None Unchecked Ratio IC50 542.0 None 10.1016/j.bmc.2010.02.034
None Unchecked Ratio IC50 755.0 None 10.1021/jm301614w
None Unchecked Ratio IC50 803.0 None 10.1021/jm0708634
None Unchecked Ratio IC50 803.0 None 10.1021/jm800918v
None Unchecked Ratio IC50 803.0 None 10.1021/jm9006406
None Unchecked Ratio IC50 803.0 None 10.1021/jm900805v
None Unchecked Ratio IC50 803.0 None 10.1021/jm901178d
None Unchecked Ratio IC50 991.0 None 10.1016/j.bmc.2009.12.011
None Unchecked Ratio IC50 991.0 None 10.1016/j.bmc.2010.11.047
None Unchecked Ratio IC50 991.0 None 10.1016/j.bmc.2011.02.045
None Unchecked Ratio IC50 1004.0 None 10.1016/j.bmc.2013.10.050
None Unchecked Ratio IC50 1004.0 None 10.1016/j.ejmech.2009.03.014
None Unchecked Ratio IC50 1004.0 None 10.1016/j.ejmech.2013.06.033
None Unchecked Ratio IC50 1004.0 None 10.1016/j.ejmech.2014.06.022
None Unchecked Ratio IC50 1004.0 None 10.1021/jm400508e
None Unchecked Ratio IC50 3353.0 None 10.1016/j.bmcl.2013.12.052
None Unchecked Ratio IC50 3614.0 None 10.1016/j.bmc.2008.10.061
None Unchecked Ratio IC50 5396.0 None 10.1016/j.ejmech.2019.04.052
None Unchecked Ratio IC50 7283.0 None 10.1016/j.bmc.2017.06.051
None Unchecked Ratio IC50 11400.0 None 10.1016/j.bmc.2016.04.006
None Unchecked Ratio IC50 11436.0 None 10.1016/j.bmc.2013.10.050
None Unchecked Ratio IC50 11436.0 None 10.1021/jm400508e
None Unchecked Ratio IC50 12000.0 None 10.1016/j.bmcl.2009.08.073
None Unchecked Ratio IC50 15533.0 None 10.1016/j.bmc.2009.12.011
None Unchecked Ratio IC50 15533.0 None 10.1016/j.bmc.2010.11.047
None Unchecked Ratio IC50 15533.0 None 10.1021/jm0708634
None Unchecked Ratio IC50 15533.0 None 10.1021/jm800918v
None Unchecked Ratio IC50 15533.0 None 10.1021/jm9006406
None Unchecked Ratio IC50 15533.0 None 10.1021/jm900805v
None Unchecked Ratio IC50 15533.0 None 10.1021/jm901178d
None Unchecked Ratio IC50 16600.0 None 10.1016/j.ejmech.2009.03.014
None Unchecked Ratio IC50 16643.0 None 10.1016/j.ejmech.2013.06.033
None Unchecked Ratio IC50 20173.0 None 10.1016/j.ejmech.2014.06.022
None Unchecked Ratio IC50 20909.0 None 10.1016/j.bmc.2011.02.045
None Unchecked Ratio IC50 nan None 10.1016/j.bmc.2009.10.042
None Unchecked Ratio IC50 nan None 10.1021/jm100507q
None Unchecked Ratio IC50 nan None 10.1039/C3MD00097D
None Unchecked Ratio LD50/IC50 4.5 None 10.1016/j.ejmech.2015.09.009
None Unchecked Selectivity Index 2.58 None 10.1016/j.bmcl.2010.08.119
None Unchecked Selectivity Index 2.8 None 10.1016/j.bmc.2010.06.099
None Unchecked Selectivity Index 4.7 None 10.1016/j.ejmech.2018.01.046
None Unchecked Selectivity Index 20.0 None 10.1007/s00044-005-0130-2

Metabolism Information