Ancistrolikokine A
AlkaPlorer ID: AK009195
Synonym: None
IUPAC Name: (1R,3R)-5-(4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl)-6-methoxy-1,2,3-trimethyl-3,4-dihydro-1H-isoquinolin-8-ol
Structure
SMILES: COC1=C(C2=CC=C(O)C3=C(OC)C=C(C)C=C23)C2=C(C(O)=C1)[C@@H](C)N(C)[C@H](C)C2
InChI: InChI=1S/C25H29NO4/c1-13-9-17-16(7-8-19(27)25(17)21(10-13)29-5)24-18-11-14(2)26(4)15(3)23(18)20(28)12-22(24)30-6/h7-10,12,14-15,27-28H,11H2,1-6H3/t14-,15-/m1/s1
InChIKey: ANPZWXGVVSLGLN-HUUCEWRRSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Ancistrocladus likoko | Ancistrocladus | Ancistrocladaceae | Caryophyllales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 407.5100000000001
TPSA？: 62.16
MolLogP？: 5.181020000000005
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 0.14 | ug.mL-1 | 10.1021/np000199t |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 0.191 | ug.mL-1 | 10.1021/np000199t |
| Rattus norvegicus | L6 | MIC | 90.0 | ug.mL-1 | 10.1021/np000199t |