Molecule

Iminoribitol

AlkaPlorer ID: AK009324

Synonym: None

IUPAC Name: (2R,3R,4S)-2-(hydroxymethyl)pyrrolidine-3,4-diol

Structure

SMILES: OC[C@H]1NC[C@H](O)[C@@H]1O

InChI: InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4+,5-/m1/s1

InChIKey: OQEBIHBLFRADNM-MROZADKFSA-N

Reference

N-containing sugars fromMorus alba and their glycosidase inhibitory activities

PubChem CID: 446222

CAS: 105990-41-8

LOTUS: LTS0233094

SuperNatural Ⅲ: SN0272324-02

NPASS: NPC10262

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Morus alba	Morus	Moraceae	Rosales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Angylocalyx pynaertii	Angylocalyx	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 133.147

TPSA？: 72.72

MolLogP？: -2.3276999999999988

Number of H-Donors: 4

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bos taurus	Alpha-L-fucosidase 1	Inhibition	50.0	%	10.1021/np010360f
Bos taurus	Beta-galactosidase	IC50	380000.0	nM	10.1021/np010360f
Coffea arabica	Alpha-galactosidase	Inhibition	50.0	%	10.1021/np010360f
Homo sapiens	Alpha-mannosidase 2A1	Ki	1430000.0	nM	10.1016/j.bmc.2012.10.011
Homo sapiens	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	Ki	1260.0	nM	10.1016/j.bmc.2012.10.011
Homo sapiens	Glycogen debranching enzyme	Inhibition	50.0	%	10.1016/j.bmc.2008.01.032
Homo sapiens	Jurkat	Activity	nan	None	10.1016/j.bmc.2011.07.053
Homo sapiens	PBMC	Activity	nan	None	10.1016/j.bmc.2011.07.053
Homo sapiens	SK-BR-3	Activity	nan	None	10.1016/j.bmc.2011.07.053
Leishmania infantum	Leishmania infantum	Activity	nan	None	10.1128/aac.01787-09
Plasmodium falciparum	Plasmodium falciparum	Activity	nan	None	10.1128/aac.01787-09
Rattus norvegicus	Acidic alpha-glucosidase	Inhibition	50.0	%	10.1021/np010360f
Rattus norvegicus	Beta-mannosidase	IC50	18000.0	nM	10.1021/np010360f
Rattus norvegicus	Sucrase-isomaltase	IC50	17000.0	nM	10.1021/np010360f
Rattus norvegicus	Sucrase-isomaltase	IC50	95000.0	nM	10.1021/np010360f
Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	64000.0	nM	10.1128/aac.01787-09
Trypanosoma cruzi	Trypanosoma cruzi	Activity	nan	None	10.1128/aac.01787-09
Trypanosoma vivax	IAG-nucleoside hydrolase	Ki	6100.0	nM	10.1016/j.ejmech.2007.03.027
None	Unchecked	IC50	27000.0	nM	10.1016/j.bmc.2008.01.032
None	Unchecked	IC50	230000.0	nM	10.1021/np010360f
None	Unchecked	IC50	1000000.0	nM	10.1021/np010360f
None	Unchecked	IC50	587489352.53	nM	10.1016/j.bmc.2012.10.011
None	Unchecked	IC50	851138038.2	nM	10.1016/j.bmc.2012.10.011
None	Unchecked	Inhibition	37.0	%	10.1016/j.bmc.2012.10.011
None	Unchecked	Inhibition	50.0	%	10.1021/np010360f
None	Unchecked	Inhibition	54.0	%	10.1016/j.bmc.2012.10.011
None	Unchecked	Ki	6000.0	nM	10.1128/aac.01787-09
None	Unchecked	Ki	10000.0	nM	10.1039/C8MD00372F