N-methyl-1-hydroxy-3-methoxyacridone
AlkaPlorer ID: AK009412
Synonym: '', '1-Hydroxy-3-methoxy-N-methylacridone'
IUPAC Name: 1-hydroxy-3-methoxy-10-methylacridin-9-one
Structure
SMILES: COC1=CC(O)=C2C(=O)C3=CC=CC=C3N(C)C2=C1
InChI: InChI=1S/C15H13NO3/c1-16-11-6-4-3-5-10(11)15(18)14-12(16)7-9(19-2)8-13(14)17/h3-8,17H,1-2H3
InChIKey: OCUBFJMZYYIVBO-UHFFFAOYSA-N
Reference
Acridone alkaloids of callus tissue ofRuta graveolens
PubChem CID: 5377412
CAS: 13161-83-6
LOTUS: LTS0138349
SuperNatural Ⅲ: SN0261904
COCONUT: CNP0285334
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Glycosmis pentaphylla | Glycosmis | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 255.273
TPSA？: 51.46
MolLogP？: 2.4059
Number of H-Donors: 1
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 786-0 | GI50 | 21478.3 | nM | None |
| Homo sapiens | A498 | GI50 | 90364.95 | nM | None |
| Homo sapiens | A549 | GI50 | 100000.0 | nM | None |
| Homo sapiens | A549 | IC50 | 31000.0 | nM | 10.1016/j.bmc.2010.03.040 |
| Homo sapiens | ACHN | GI50 | 14028.14 | nM | None |
| Homo sapiens | BT-549 | GI50 | 52239.62 | nM | None |
| Homo sapiens | CAKI-1 | GI50 | 100000.0 | nM | None |
| Homo sapiens | CCRF-CEM | GI50 | 24043.63 | nM | None |
| Homo sapiens | COLO 205 | GI50 | 100000.0 | nM | None |
| Homo sapiens | DLD-1 | IC50 | 27000.0 | nM | 10.1016/j.bmc.2010.03.040 |
| Homo sapiens | DU-145 | GI50 | 100000.0 | nM | None |
| Homo sapiens | EKVX | GI50 | 554.63 | nM | None |
| Homo sapiens | HaCaT | Activity | nan | None | 10.1016/j.ejmech.2010.08.059 |
| Homo sapiens | HaCaT | IC50 | 50000.0 | nM | 10.1016/j.ejmech.2010.08.059 |
| Homo sapiens | HCC 2998 | GI50 | 100000.0 | nM | None |
| Homo sapiens | HCT-116 | GI50 | 10232.93 | nM | None |
| Homo sapiens | HCT-15 | GI50 | 43451.02 | nM | None |
| Homo sapiens | HL-60 | GI50 | 100000.0 | nM | None |
| Homo sapiens | HOP-62 | GI50 | 15922.09 | nM | None |
| Homo sapiens | HOP-92 | GI50 | 46131.76 | nM | None |
| Homo sapiens | Hs-578T | GI50 | 13396.77 | nM | None |
| Homo sapiens | HT-29 | GI50 | 100000.0 | nM | None |
| Homo sapiens | IGROV-1 | GI50 | 100000.0 | nM | None |
| Homo sapiens | K562 | GI50 | 100000.0 | nM | None |
| Homo sapiens | KM12 | GI50 | 100000.0 | nM | None |
| Homo sapiens | LOX IMVI | GI50 | 84527.88 | nM | None |
| Homo sapiens | M14 | GI50 | 100000.0 | nM | None |
| Homo sapiens | Malme-3M | GI50 | 100000.0 | nM | None |
| Homo sapiens | MCF7 | GI50 | 100000.0 | nM | None |
| Homo sapiens | MDA-MB-231 | GI50 | 71285.3 | nM | None |
| Homo sapiens | MDA-MB-435 | GI50 | 100000.0 | nM | None |
| Homo sapiens | MDA-N | GI50 | 100000.0 | nM | None |
| Homo sapiens | MOLT-4 | GI50 | 8433.35 | nM | None |
| Homo sapiens | NCI/ADR-RES | GI50 | 32658.78 | nM | None |
| Homo sapiens | NCI-H226 | GI50 | 100000.0 | nM | None |
| Homo sapiens | NCI-H23 | GI50 | 100000.0 | nM | None |
| Homo sapiens | NCI-H322M | GI50 | 100000.0 | nM | None |
| Homo sapiens | NCI-H460 | GI50 | 4477.13 | nM | None |
| Homo sapiens | NCI-H522 | GI50 | 22284.35 | nM | None |
| Homo sapiens | OVCAR-3 | GI50 | 100000.0 | nM | None |
| Homo sapiens | OVCAR-4 | GI50 | 89330.55 | nM | None |
| Homo sapiens | OVCAR-5 | GI50 | 100000.0 | nM | None |
| Homo sapiens | OVCAR-8 | GI50 | 18663.8 | nM | None |
| Homo sapiens | PC-3 | GI50 | 100000.0 | nM | None |
| Homo sapiens | RXF 393 | GI50 | 14859.36 | nM | None |
| Homo sapiens | SF-268 | GI50 | 53703.18 | nM | None |
| Homo sapiens | SF-295 | GI50 | 27669.42 | nM | None |
| Homo sapiens | SF-539 | GI50 | 28379.19 | nM | None |
| Homo sapiens | SK-MEL-2 | GI50 | 100000.0 | nM | None |
| Homo sapiens | SK-MEL-28 | GI50 | 100000.0 | nM | None |
| Homo sapiens | SK-MEL-5 | GI50 | 4655.86 | nM | None |
| Homo sapiens | SK-OV-3 | GI50 | 26791.68 | nM | None |
| Homo sapiens | SN12C | GI50 | 100000.0 | nM | None |
| Homo sapiens | SNB-19 | GI50 | 252.93 | nM | None |
| Homo sapiens | SR | GI50 | 7261.06 | nM | None |
| Homo sapiens | SW-620 | GI50 | 63826.35 | nM | None |
| Homo sapiens | T47D | GI50 | 100000.0 | nM | None |
| Homo sapiens | TK-10 | GI50 | 20137.24 | nM | None |
| Homo sapiens | U-251 | GI50 | 29444.22 | nM | None |
| Homo sapiens | UACC-257 | GI50 | 100000.0 | nM | None |
| Homo sapiens | UACC-62 | GI50 | 24603.68 | nM | None |
| Homo sapiens | UO-31 | GI50 | 6854.88 | nM | None |
| None | NON-PROTEIN TARGET | IC50 | 51000.0 | nM | 10.1016/j.bmc.2010.03.040 |
| None | Radical scavenging activity | EC50 | nan | None | 10.1016/j.ejmech.2010.08.059 |