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D-4-hydroxyphenylglycine

AlkaPlorer ID: AK009762

Synonym: 'L-4-hydroxyphenylglycine', 'D-4-Hydroxyphenylglycine', '4-HYDROXYPHENYLGLYCINE', '(R)-alpha-Amino-4-hydroxybenzeneacetic acid', '4-Hydroxyphenylglycine', 'D-N-(4-Hydroxyphenyl)glycine'

IUPAC Name: (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid

Structure

SMILES: N[C@H](C(=O)O)C1=CC=C(O)C=C1

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InChI: InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m0/s1

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InChIKey: LJCWONGJFPCTTL-ZETCQYMHSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Daphnia pulex Daphnia Daphniidae Diplostraca Branchiopoda Arthropoda Metazoa Eukaryota

Properties Information

Molecule Weight: 167.164

TPSA？: 83.55000000000001

MolLogP？: 0.4766

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Carnitine O-palmitoyltransferase 1, liver isoform IC50 100000.0 nM 10.1021/jm100809g
Homo sapiens Carnitine O-palmitoyltransferase 1, muscle isoform IC50 100000.0 nM 10.1021/jm100809g
Homo sapiens Carnitine palmitoyltransferase 2 IC50 100000.0 nM 10.1021/jm100809g
Homo sapiens Galactocerebrosidase Potency 316.2 nM None
Homo sapiens KB IC50 100000.0 nM 10.1021/jm100809g
Homo sapiens Neutral amino acid transporter A IC50 1322000.0 nM None
Homo sapiens Neutral amino acid transporter A IC50 2000000.0 nM None
Homo sapiens Neutral amino acid transporter B(0) IC50 1728000.0 nM None
Homo sapiens Neutral amino acid transporter B(0) IC50 2000000.0 nM None
Rattus norvegicus Amino acid transporter IC50 142100.0 nM None
Rattus norvegicus Amino acid transporter IC50 283000.0 nM None
Rattus norvegicus Amino acid transporter Inhibition 25.0 % None
Rattus norvegicus Asc-type amino acid transporter 1 IC50 101000.0 nM None
Rattus norvegicus Glutamate NMDA receptor Activity 22.0 % None
Rattus norvegicus Glutamate NMDA receptor Activity nan None None
Rattus norvegicus Rattus norvegicus Activity nan None None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 35.77 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.07 % 10.6019/CHEMBL4495565
None Unchecked Ac50 0.2818 uM None
None Unchecked Ac50 0.3162 uM None
None Unchecked Ac50 22.39 uM None
None Unchecked AC50 281.8 nM None
None Unchecked AC50 316.2 nM None
None Unchecked AC50 22387.2 nM None
None Unchecked Activity 10.0 uM None
None Unchecked IC50 100000.0 nM 10.1021/jm100809g

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT019942 N[C@@H](Cc1ccc(O)cc1)C(=O)O.O=C(O)C(=O)c1ccc(O)cc1>>N[C@H](C(=O)O)c1ccc(O)cc1 R06626
AKRT020206 N[C@H](C(=O)O)c1ccc(O)cc1>>N[C@H](C(=O)O)c1ccc(OS(=O)(=O)O)cc1 enzymemap_50005