Neopyrrolomycin B
AlkaPlorer ID: AK010290
Synonym: None
IUPAC Name: 3,4,5-trichloro-2-(2,3,4-trichloropyrrol-1-yl)phenol
Structure
SMILES: OC1=CC(Cl)=C(Cl)C(Cl)=C1N1C=C(Cl)C(Cl)=C1Cl
InChI: InChI=1S/C10H3Cl6NO/c11-3-1-5(18)9(8(15)6(3)13)17-2-4(12)7(14)10(17)16/h1-2,18H
InChIKey: NTKHEOJBPXFULD-UHFFFAOYSA-N
Reference
Neopyrrolomycins with Broad Spectrum Antibacterial Activity
PubChem CID: 25227595
CAS: 1125638-83-6
LOTUS: LTS0104640
SuperNatural Ⅲ: SN0254805
COCONUT: CNP0281071
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | None | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 365.85800000000006
TPSA？: 25.16
MolLogP？: 6.103300000000001
Number of H-Donors: 1
Number of H-Acceptors: 2
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Enterococcus faecalis | Enterococcus faecalis | MIC90 | 0.06 | ug.mL-1 | 10.1021/np800632f |
| Enterococcus faecium | Enterococcus faecium | MIC90 | 0.06 | ug.mL-1 | 10.1021/np800632f |
| Enterococcus faecium | Enterococcus faecium | MIC90 | 0.5 | ug.mL-1 | 10.1021/np800632f |
| Escherichia coli | Escherichia coli | MIC90 | 8.0 | ug.mL-1 | 10.1021/np800632f |
| Escherichia coli | Escherichia coli | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |
| Haemophilus influenzae | Haemophilus influenzae | MIC90 | 0.25 | ug.mL-1 | 10.1021/np800632f |
| Haemophilus influenzae | Haemophilus influenzae | MIC90 | 0.5 | ug.mL-1 | 10.1021/np800632f |
| Haemophilus parainfluenzae | Haemophilus parainfluenzae | MIC90 | 1.0 | ug.mL-1 | 10.1021/np800632f |
| Homo sapiens | HepG2 | Activity | nan | None | 10.1021/np800632f |
| Homo sapiens | NHDF | CC90 | 16.0 | ug ml-1 | 10.1021/np800632f |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC90 | 8.0 | ug.mL-1 | 10.1021/np800632f |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |
| Moraxella catarrhalis | Moraxella catarrhalis | MIC90 | 0.06 | ug.mL-1 | 10.1021/np800632f |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |
| Serratia marcescens | Serratia marcescens | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |
| Staphylococcus aureus | Staphylococcus aureus | MBC | 2.0 | ug ml-1 | 10.1021/np800632f |
| Staphylococcus aureus | Staphylococcus aureus | MIC90 | 0.06 | ug.mL-1 | 10.1021/np800632f |
| Staphylococcus aureus | Staphylococcus aureus | MIC90 | 0.12 | ug.mL-1 | 10.1021/np800632f |
| Staphylococcus aureus | Staphylococcus aureus | MIC90 | 0.125 | ug.mL-1 | 10.1021/np800632f |
| Staphylococcus aureus | Staphylococcus aureus | MIC90 | 0.25 | ug.mL-1 | 10.1021/np800632f |
| Staphylococcus aureus | Staphylococcus aureus | MIC90 | 0.5 | ug.mL-1 | 10.1021/np800632f |
| Staphylococcus epidermidis | Staphylococcus epidermidis | MIC90 | 0.06 | ug.mL-1 | 10.1021/np800632f |
| Streptococcus agalactiae | Streptococcus agalactiae | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC90 | 1.0 | ug.mL-1 | 10.1021/np800632f |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC90 | 2.0 | ug.mL-1 | 10.1021/np800632f |
| Streptococcus pneumoniae | Streptococcus pneumoniae | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |
| Streptococcus pyogenes | Streptococcus pyogenes | MIC90 | 16.0 | ug.mL-1 | 10.1021/np800632f |