4-Hydroxytryptamine; 2'-N-Me
AlkaPlorer ID: AK010400
Synonym: 4-Hydroxy-3-[2-(methylamino)ethyl]indole, 4-Hydroxy-N-methyltryptamine, Norpsilocin
IUPAC Name: 3-[2-(methylamino)ethyl]-1H-indol-4-ol
Structure
SMILES: CNCCC1=CNC2=CC=CC(O)=C12
InChI: InChI=1S/C11H14N2O/c1-12-6-5-8-7-13-9-3-2-4-10(14)11(8)9/h2-4,7,12-14H,5-6H2,1H3
InChIKey: MTJOWJUQGYWRHT-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Psilocybe cubensis | Psilocybe | Strophariaceae | Agaricales | Agaricomycetes | Basidiomycota | Fungi | Eukaryota |
| None | Psilocybe | Strophariaceae | Agaricales | Agaricomycetes | Basidiomycota | Fungi | Eukaryota |
Properties Information
Molecule Weight: 190.246
TPSA？: 48.05
MolLogP？: 1.6354
Number of H-Donors: 3
Number of H-Acceptors: 2
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Serotonin 2a (5-HT2a) receptor | EC50 | 8.318 | nM | 10.1021/acs.jnatprod.9b01061 |
| Homo sapiens | Serotonin 2a (5-HT2a) receptor | EC50 | 8.4 | nM | 10.1021/acs.jnatprod.9b01061 |
| Homo sapiens | Serotonin 2a (5-HT2a) receptor | Emax | 93.0 | % | 10.1021/acs.jnatprod.9b01061 |
| Mus musculus | Serotonin 2a (5-HT2a) receptor | EC50 | 19.0 | nM | 10.1021/acs.jnatprod.9b01061 |
| Mus musculus | Serotonin 2a (5-HT2a) receptor | EC50 | 19.05 | nM | 10.1021/acs.jnatprod.9b01061 |
| Mus musculus | Serotonin 2a (5-HT2a) receptor | Emax | 99.0 | % | 10.1021/acs.jnatprod.9b01061 |