Kasugamycin
AlkaPlorer ID: AK010501
Synonym: None
IUPAC Name: 2-amino-2-[(2R,3S,5S,6R)-5-amino-2-methyl-6-[(2S,3S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyoxan-3-yl]iminoacetic acid
Structure
SMILES: C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(=N)C(=O)O
InChI: InChI=1S/C14H25N3O9/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24)/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-/m1/s1
InChIKey: PVTHJAPFENJVNC-MHRBZPPQSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces kasugaensis | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 379.36600000000016
TPSA？: 218.81
MolLogP？: -4.328029999999994
Number of H-Donors: 9
Number of H-Acceptors: 10
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | MIC | 500.0 | ug.mL-1 | 10.1128/aac.00873-08 |
| Bacillus subtilis | Bacillus subtilis | MIC | 1500.0 | ug.mL-1 | 10.1128/aac.00873-08 |
| Bacillus subtilis | Bacillus subtilis | MIC | 4000.0 | ug.mL-1 | 10.1128/aac.00873-08 |
| Bacillus subtilis | Bacillus subtilis | MIC | 5000.0 | ug.mL-1 | 10.1128/aac.00873-08 |
| Bacillus subtilis | Bacillus subtilis | MIC | 15000.0 | ug.mL-1 | 10.1128/aac.00873-08 |
| Escherichia coli | Escherichia coli | MIC | 200.0 | ug.mL-1 | 10.1128/aac.00873-08 |