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Auricin

AlkaPlorer ID: AK010515

Synonym: None

IUPAC Name: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

Structure

SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O

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InChI: InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

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InChIKey: MQTOSJVFKKJCRP-BICOPXKESA-N

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Properties Information

Molecule Weight: 748.9960000000001

TPSA？: 180.08

MolLogP？: 1.9007000000000047

Number of H-Donors: 5

Number of H-Acceptors: 14

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter Acinetobacter MIC 8.0 ug.mL-1 10.1128/aac.01115-07
Acinetobacter Acinetobacter MIC nan None 10.1128/aac.01115-07
Acinetobacter baumannii Acinetobacter baumannii Inhibition nan % 10.1128/aac.00471-08
Acinetobacter baumannii Acinetobacter baumannii log10cfu nan None 10.1128/aac.00471-08
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 1.5 ug.mL-1 10.1128/aac.01439-09
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1128/aac.00834-10
Acinetobacter baumannii Acinetobacter baumannii MIC 24.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00834-10
Acinetobacter baumannii Acinetobacter baumannii MIC 96.0 ug.mL-1 10.1128/aac.00732-07
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1128/aac.00072-08
Acinetobacter baumannii Acinetobacter baumannii MIC 10000.0 nM 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC nan None 10.1128/aac.00471-08
Acinetobacter baumannii Acinetobacter baumannii Ratio 21.0 None 10.1128/aac.01439-09
Acinetobacter pittii Acinetobacter pittii MIC 4.0 ug.mL-1 10.1128/aac.00072-08
Bacillus anthracis Bacillus anthracis MIC 1.0 ug.mL-1 10.1128/aac.00737-08
Bacillus anthracis Bacillus anthracis MIC 2.0 ug.mL-1 10.1128/aac.00737-08
Bacillus anthracis Bacillus anthracis MIC 4.0 ug.mL-1 10.1128/aac.00737-08
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2017.07.017
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.06.006
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2019.126850
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128110
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128330
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.07.022
Bacillus subtilis Bacillus subtilis MIC 0.5 ug.mL-1 10.1016/j.bmcl.2018.09.012
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Bacillus subtilis Bacillus subtilis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2015.05.070
Bacillus subtilis Bacillus subtilis MIC 150.0 nM 10.1021/jm101593u
Bacillus subtilis Bacillus subtilis MIC 1000.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Bacillus subtilis Bacillus subtilis MIC 1000.0 ug.mL-1 10.1016/s0960-894x(98)00227-3
Bacteria Bacterial 70S ribosome IC50 300.0 nM 10.1016/j.bmc.2009.07.013
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Burkholderia cepacia Burkholderia cepacia INH 16.0 ug ml-1 10.1016/j.bmc.2019.115229
Burkholderia pseudomallei Burkholderia pseudomallei MIC 0.25 ug.mL-1 10.1128/aac.01033-06
Burkholderia pseudomallei Burkholderia pseudomallei MIC 8.0 ug.mL-1 10.1128/aac.01033-06
Burkholderia pseudomallei Burkholderia pseudomallei MIC 16.0 ug.mL-1 10.1128/aac.01033-06
Burkholderia pseudomallei Burkholderia pseudomallei MIC 32.0 ug.mL-1 10.1128/aac.01033-06
Campylobacter coli Campylobacter coli Activity 38.9 % 10.1128/aac.00898-09
Campylobacter jejuni Campylobacter jejuni Activity 5.0 % 10.1128/aac.00898-09
Candida albicans Candida albicans MIC 10000.0 nM 10.6019/CHEMBL4513141
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlamydia Chlamydia Activity nan None 10.1021/jm960294s
Chlamydia pneumoniae Chlamydia pneumoniae MBC90 0.125 ug ml-1 10.1128/aac.01343-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.00046-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC50 0.125 ug.mL-1 10.1128/aac.01343-09
Chlamydia pneumoniae Chlamydia pneumoniae MIC90 0.125 ug.mL-1 10.1128/aac.01343-09
Chlamydia psittaci 6BC Chlamydia psittaci 6BC Activity nan None 10.1128/aac.00962-07
Chlamydia psittaci 6BC Chlamydia psittaci 6BC MIC 0.1 ug.mL-1 10.1128/aac.00962-07
Chlamydia psittaci 6BC Chlamydia psittaci 6BC MIC 20.0 ug.mL-1 10.1128/aac.00962-07
Chlamydia trachomatis Chlamydia trachomatis IC50 727.0 nM 10.1016/j.ejmech.2017.11.099
Chlamydia trachomatis Chlamydia trachomatis IC50 nan None 10.1016/j.ejmech.2017.11.099
Chlamydia trachomatis Chlamydia trachomatis Inhibition nan % 10.1021/acs.jmedchem.0c00371
Chlamydia trachomatis Chlamydia trachomatis MBC 0.015 ug ml-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MBC 0.5 ug ml-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MBC 1.0 ug ml-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MBC90 0.12 ug ml-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MBC90 0.125 ug ml-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MIC 0.015 ug.mL-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.1 ug.mL-1 10.1128/aac.00962-07
Chlamydia trachomatis Chlamydia trachomatis MIC 0.125 ug.mL-1 10.1128/aac.00046-09
Chlamydia trachomatis Chlamydia trachomatis MIC 0.25 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.5 ug.mL-1 10.1128/aac.00553-10
Chlamydia trachomatis Chlamydia trachomatis MIC 0.8 ug.mL-1 10.1128/aac.00962-07
Chlamydia trachomatis Chlamydia trachomatis MIC50 0.125 ug.mL-1 10.1128/aac.01343-09
Chlamydia trachomatis Chlamydia trachomatis MIC90 0.12 ug.mL-1 10.1128/aac.00235-10
Chlamydia trachomatis Chlamydia trachomatis MIC90 0.125 ug.mL-1 10.1128/aac.01343-09
Chlorocebus sabaeus Vero CC50 40000.0 nM 10.1016/j.ejmech.2020.112739
Chlorocebus sabaeus Vero CC50 130000.0 nM 10.1016/j.ejmech.2020.112739
Chlorocebus sabaeus Vero CC50 810000.0 nM 10.1016/j.ejmech.2020.112739
Chlorocebus sabaeus Vero CC50 nan None 10.1016/j.bmcl.2019.03.038
Chlorocebus sabaeus Vero C1008 AUC cytotoxicity 223.9 None 10.1038/s41586-020-2286-9
Chlorocebus sabaeus Vero C1008 CC50 40000.0 nM 10.1101/2020.04.03.023846
Chlorocebus sabaeus Vero C1008 pCC50 15.82 None 10.1038/s41586-020-2286-9
Chromobacterium violaceum Chromobacterium violaceum Activity 67.2 % 10.1016/j.bmcl.2020.127336
Chromobacterium violaceum Chromobacterium violaceum Activity 85.6 % 10.1016/j.bmcl.2020.127336
Citrobacter koseri Citrobacter koseri Activity 99.0 % 10.1128/aac.00418-09
Citrobacter koseri Citrobacter koseri MIC 2.0 ug.mL-1 10.1128/aac.00418-09
Citrobacter koseri Citrobacter koseri MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Citrobacter koseri Citrobacter koseri MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Cryptococcus neoformans Cryptococcus neoformans MIC 10000.0 nM 10.6019/CHEMBL4513141
dengue virus type 2 dengue virus type 2 EC50 3710.0 nM 10.1016/j.ejmech.2020.112739
Enterobacter cloacae Enterobacter cloacae MIC 0.19 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 0.25 ug.mL-1 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae MIC 0.438 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 1.0 ug.mL-1 10.1016/S0960-894X(00)80333-9
Enterobacter cloacae Enterobacter cloacae MIC 1.5 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 4.0 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae MIC 6.0 ug.mL-1 10.1128/aac.00405-08
Enterobacter cloacae Enterobacter cloacae Ratio 16.0 None 10.1128/aac.01439-09
Enterobacter cloacae Enterobacter cloacae Ratio 32.0 None 10.1128/aac.00405-08
Enterococcus Enterococcus MIC50 10.0 ug.mL-1 10.1021/jm980240d
Enterococcus Enterococcus MIC50 40.0 ug.mL-1 10.1021/jm980240d
Enterococcus Enterococcus MIC90 40.0 ug.mL-1 10.1021/jm980240d
Enterococcus faecalis Enterococcus faecalis Activity nan None 10.1128/aac.00418-09
Enterococcus faecalis Enterococcus faecalis MIC 0.125 ug.mL-1 10.1039/d2md00143h
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1128/aac.00418-09
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/j.bmc.2016.06.044
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/S0960-894X(00)80333-9
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1016/S0960-894X(01)80238-9
Enterococcus faecalis Enterococcus faecalis MIC 4.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1021/np4006794
Enterococcus faecalis Enterococcus faecalis MIC 8.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecalis Enterococcus faecalis MIC 32.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Enterococcus faecalis Enterococcus faecalis MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecalis Enterococcus faecalis MIC 256.0 ug.mL-1 10.1021/np4006794
Enterococcus faecalis Enterococcus faecalis MIC 4000.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Enterococcus faecalis Enterococcus faecalis MIC 4000.0 ug.mL-1 10.1016/s0960-894x(98)00227-3
Enterococcus faecalis Enterococcus faecalis MIC nan None 10.1016/j.bmcl.2010.11.079
Enterococcus faecalis Enterococcus faecalis MIC50 4.0 ug.mL-1 10.1128/aac.01315-06
Enterococcus faecalis Enterococcus faecalis MIC50 128.0 ug.mL-1 10.1128/aac.00418-09
Enterococcus faecalis Enterococcus faecalis MIC90 16.0 ug.mL-1 10.1128/aac.01315-06
Enterococcus faecalis Enterococcus faecalis MIC90 128.0 ug.mL-1 10.1021/jm500462x
Enterococcus faecalis Enterococcus faecalis MIC90 128.0 ug.mL-1 10.1128/aac.00418-09
Enterococcus faecium Enterococcus faecium Activity nan None 10.1128/aac.00418-09
Enterococcus faecium Enterococcus faecium MIC 0.06 ug.mL-1 10.1128/aac.00418-09
Enterococcus faecium Enterococcus faecium MIC 2.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecium Enterococcus faecium MIC 4.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecium Enterococcus faecium MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Enterococcus faecium Enterococcus faecium MIC 8.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecium Enterococcus faecium MIC 16.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecium Enterococcus faecium MIC 25.0 ug.mL-1 10.1016/j.bmcl.2019.03.038
Enterococcus faecium Enterococcus faecium MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Enterococcus faecium Enterococcus faecium MIC 250.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Enterococcus faecium Enterococcus faecium MIC 250.0 ug.mL-1 10.1016/s0960-894x(98)00227-3
Enterococcus faecium Enterococcus faecium MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Enterococcus faecium Enterococcus faecium MIC 256.0 ug.mL-1 10.1021/np4006794
Enterococcus faecium Enterococcus faecium MIC50 16.0 ug.mL-1 10.1128/aac.01315-06
Enterococcus faecium Enterococcus faecium MIC50 128.0 ug.mL-1 10.1128/aac.00418-09
Enterococcus faecium Enterococcus faecium MIC90 16.0 ug.mL-1 10.1128/aac.01315-06
Enterococcus faecium Enterococcus faecium MIC90 128.0 ug.mL-1 10.1021/jm500462x
Enterococcus faecium Enterococcus faecium MIC90 128.0 ug.mL-1 10.1128/aac.00418-09
Enterococcus gallinarum Enterococcus gallinarum MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Escherichia coli Escherichia coli AC50 29341.0 nM None
Escherichia coli Escherichia coli Activity 41.0 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 78.0 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmcl.2018.11.038
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01266-07
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.01783-09
Escherichia coli Escherichia coli FICI 0.157 None 10.1128/aac.00405-08
Escherichia coli Escherichia coli Inhibition 20.0 % 10.1128/aac.00471-08
Escherichia coli Escherichia coli Inhibition nan % 10.1016/j.bmc.2019.115229
Escherichia coli Escherichia coli Inhibition nan % 10.1128/aac.00471-08
Escherichia coli Escherichia coli log10cfu nan None 10.1128/aac.00471-08
Escherichia coli Escherichia coli MBC 5.0 ug ml-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 0.064 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.094 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01439-09
Escherichia coli Escherichia coli MIC 0.173 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.19 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1021/np060334n
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1039/d2md00143h
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 0.75 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.bmc.2016.06.044
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/S0960-894X(00)80333-9
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/S0960-894X(01)80238-9
Escherichia coli Escherichia coli MIC 1.56 ug.mL-1 10.1016/s0960-894x(02)00434-1
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmc.2012.03.074
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.01783-09
Escherichia coli Escherichia coli MIC 2.6 ug.mL-1 10.1128/aac.01783-09
Escherichia coli Escherichia coli MIC 3.0 ug.mL-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 3.0 ug.mL-1 10.1128/aac.00405-08
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.01783-09
Escherichia coli Escherichia coli MIC 6.25 ug.mL-1 10.1016/j.ejmech.2018.12.017
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmc.2015.10.042
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 20.0 ug.mL-1 10.1016/s0960-894x(98)00402-8
Escherichia coli Escherichia coli MIC 20.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Escherichia coli Escherichia coli MIC 20.0 ug.mL-1 10.1021/jm980240d
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1016/j.bmcl.2010.12.111
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1021/np4006794
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1021/np4006794
Escherichia coli Escherichia coli MIC 1560.0 ug.mL-1 10.1021/acs.jmedchem.1c00790
Escherichia coli Escherichia coli MIC 10000.0 nM 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00471-08
Escherichia coli Escherichia coli MIC nan None 10.1128/aac.00921-08
Escherichia coli Escherichia coli MIC50 4.0 ug.mL-1 10.1016/j.bmc.2015.04.078
Escherichia coli Escherichia coli MIC80 256.0 ug.mL-1 10.1016/j.bmcl.2013.07.042
Escherichia coli Escherichia coli Ratio 4.0 None 10.1128/aac.00921-08
Escherichia coli Escherichia coli Ratio 8.0 None 10.1128/aac.01439-09
Escherichia coli Escherichia coli Ratio 16.0 None 10.1128/aac.01439-09
Escherichia coli Escherichia coli Ratio 24.0 None 10.1128/aac.00405-08
Escherichia coli Escherichia coli Ratio 31.0 None 10.1128/aac.00405-08
Haemophilus Haemophilus MIC50 0.15 ug.mL-1 10.1021/jm980240d
Haemophilus Haemophilus MIC50 0.3 ug.mL-1 10.1021/jm980240d
Haemophilus Haemophilus MIC90 1.2 ug.mL-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae Activity 0.0 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 1.2 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 2.7 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 4.1 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 23.8 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 44.0 min 10.1128/aac.00607-07
Haemophilus influenzae Haemophilus influenzae Activity 81.8 ug ml-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae Activity 95.9 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 97.3 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 98.1 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 98.7 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 98.8 % 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae Activity 98.9 % 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae Activity 100.0 % 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae Activity 100.0 ug ml-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae Activity nan None 10.1021/jm960294s
Haemophilus influenzae Haemophilus influenzae Activity nan None 10.1128/aac.00607-07
Haemophilus influenzae Haemophilus influenzae ED50 109.0 mg.kg-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae ED50 117.0 mg.kg-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae ED50 368.0 mg.kg-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae FC 22.0 None 10.1016/j.ejmech.2020.112222
Haemophilus influenzae Haemophilus influenzae Inhibition nan % 10.1128/aac.00471-08
Haemophilus influenzae Haemophilus influenzae log10cfu 8.14 None 10.1128/aac.00471-08
Haemophilus influenzae Haemophilus influenzae log10CFU/g 6.0 None 10.1021/jm201467r
Haemophilus influenzae Haemophilus influenzae MBC 8.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Haemophilus influenzae Haemophilus influenzae MBC 8.0 ug ml-1 10.1016/j.ejmech.2020.112222
Haemophilus influenzae Haemophilus influenzae MIC 0.001 ug.mL-1 10.1128/aac.00471-08
Haemophilus influenzae Haemophilus influenzae MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1021/acs.jmedchem.9b01159
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC 0.25 ug.mL-1 10.1128/aac.01383-07
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/j.bmc.2016.06.044
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/j.bmcl.2012.06.092
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/S0960-894X(00)80333-9
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/S0960-894X(01)80238-9
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1128/aac.00607-07
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2012.03.074
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1021/jm100711p
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1021/ml100253p
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1021/ml500279k
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1039/C4MD00489B
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC 1.0 ug.mL-1 10.1128/aac.01383-07
Haemophilus influenzae Haemophilus influenzae MIC 1.2 ug.mL-1 10.1016/s0960-894x(00)00392-9
Haemophilus influenzae Haemophilus influenzae MIC 1.2 ug.mL-1 10.1016/s0960-894x(98)00402-8
Haemophilus influenzae Haemophilus influenzae MIC 1.2 ug.mL-1 10.1016/s0960-894x(99)00534-x
Haemophilus influenzae Haemophilus influenzae MIC 1.2 ug.mL-1 10.1021/jm980240d
Haemophilus influenzae Haemophilus influenzae MIC 1.56 ug.mL-1 10.1021/jm020568d
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1016/j.bmc.2015.10.042
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.03.076
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2012.01.039
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1021/jm300356u
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC 2.0 ug.mL-1 10.1128/aac.01383-07
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2005.01.027
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1128/aac.01383-07
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1016/S0960-894X(00)80333-9
Haemophilus influenzae Haemophilus influenzae MIC 8.0 ug.mL-1 10.1021/np060334n
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Haemophilus influenzae Haemophilus influenzae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Haemophilus influenzae Haemophilus influenzae MIC50 0.25 ug.mL-1 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae MIC50 0.5 ug.mL-1 10.1128/aac.01315-06
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae MIC50 1.0 ug.mL-1 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae MIC50 2.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC50 1000.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Haemophilus influenzae Haemophilus influenzae MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Haemophilus influenzae Haemophilus influenzae MIC90 1.0 ug.mL-1 10.1128/aac.01548-09
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1021/jm500462x
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.00971-07
Haemophilus influenzae Haemophilus influenzae MIC90 2.0 ug.mL-1 10.1128/aac.01315-06
Haemophilus influenzae Haemophilus influenzae MIC90 4.0 ug.mL-1 10.1128/aac.00054-10
Haemophilus influenzae Haemophilus influenzae MIC90 4.0 ug.mL-1 10.1128/aac.00422-07
Haemophilus influenzae Haemophilus influenzae MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Haemophilus influenzae Haemophilus influenzae MIC90 2000.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Haemophilus influenzae Haemophilus influenzae Ratio 4.0 None 10.1016/j.ejmech.2020.112222
Haemophilus influenzae Haemophilus influenzae Selectivity ratio 4.0 None 10.1016/j.ejmech.2019.02.073
Homo sapiens A549 CC50 600000.0 nM 10.1016/j.ejmech.2020.112739
Homo sapiens Acetylcholinesterase AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile salt export pump AC50 200000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Blood Cmax 2683.58 nM 10.1021/jm300356u
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 100000.0 nM None
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Inhibition 68.0 % 10.1021/jm400813y
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Inhibition 99.0 % 10.1021/jm400813y
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome c oxidase subunit 1 Inhibition 30.0 % 10.1021/acsmedchemlett.0c00632
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 10000.0 nM 10.1021/jm300356u
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Delta opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 259.3 nM None
Homo sapiens Geminin Potency 13335.9 nM None
Homo sapiens Geminin Potency 18356.4 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon-like peptide 1 receptor Potency 11220.2 nM None
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4513141
Homo sapiens HeLa IC20 50.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens HeLa IC20 110.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens HeLa IC50 160.0 ug.mL-1 10.1128/aac.00729-05
Homo sapiens HeLa IC50 240.0 ug.mL-1 10.1128/aac.00729-05
Homo sapiens HepG2 IC50 50000.0 nM 10.1021/jm2001585
Homo sapiens HepG2 IC50 50000.0 nM 10.1021/jm201615t
Homo sapiens HepG2 IC50 203000.0 nM 10.1016/j.ejmech.2012.01.039
Homo sapiens HepG2 IC50 203000.0 nM 10.1021/jm201676t
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HFF CC50 174000.0 nM 10.1021/jm101593u
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition 3.52 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 8.17 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens AUC 3390.0 ng.hr.mL-1 10.1128/aac.01270-08
Homo sapiens Homo sapiens CL 9.6 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 10.0 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 10.0 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.45 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL_renal 0.5 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Cmax 534.05 nM 10.1128/aac.00375-07
Homo sapiens Homo sapiens Cmax 534.05 nM 10.1128/aac.01270-08
Homo sapiens Homo sapiens Cmax 1100.0 nM 10.1128/aac.00527-07
Homo sapiens Homo sapiens Cmax 1335.11 nM 10.1128/aac.01605-07
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 7.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fa 0.6 None 10.1021/jm901371v
Homo sapiens Homo sapiens F_fraction 0.34 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.97 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.58 None 10.1021/jm901371v
Homo sapiens Homo sapiens T1/2 10.0 hr 10.1128/aac.01605-07
Homo sapiens Homo sapiens T1/2 11.0 hr 10.1128/aac.01270-08
Homo sapiens Homo sapiens T1/2 35.0 hr 10.1128/aac.01270-08
Homo sapiens Homo sapiens T1/2 68.0 hr 10.1128/aac.01011-06
Homo sapiens Homo sapiens T1/2 69.0 hr 10.1021/acs.jmedchem.5b00201
Homo sapiens Homo sapiens T1/2 74.0 hr 10.1128/aac.00527-07
Homo sapiens Homo sapiens Tmax 2.4 hr 10.1128/aac.00527-07
Homo sapiens Homo sapiens Vd 33.0 L.kg-1 10.1021/acs.jmedchem.5b00201
Homo sapiens Homo sapiens Vdss 33.0 L.kg-1 10.1021/jm901371v
Homo sapiens IB3-1 Activity 35.0 % 10.1128/aac.01142-06
Homo sapiens IB3-1 Activity 40.0 % 10.1128/aac.01142-06
Homo sapiens IB3-1 Activity 45.0 % 10.1128/aac.01142-06
Homo sapiens IB3-1 Activity 60.0 % 10.1128/aac.01142-06
Homo sapiens Interleukin-8 Potency 66824.2 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 5804.8 nM None
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Liver Stability 100.0 % 10.1016/j.ejmech.2016.09.022
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens Liver microsomes T1/2 2.0 hr 10.1021/jm2001585
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MG-63 Activity 30.0 % 10.1128/aac.00729-05
Homo sapiens MG-63 IC20 30.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens MG-63 IC20 70.0 ug ml-1 10.1128/aac.00729-05
Homo sapiens MG-63 IC50 180.0 ug.mL-1 10.1128/aac.00729-05
Homo sapiens MG-63 IC50 190.0 ug.mL-1 10.1128/aac.00729-05
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens NCI-H292 Drug uptake 77.0 % 10.1021/jm101317f
Homo sapiens NCI-H292 Drug uptake 100.0 % 10.1021/jm101317f
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Nuclear receptor ROR-gamma Potency 33491.5 nM None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1016/j.ejphar.2003.11.035
Homo sapiens P-glycoprotein 1 Activity nan None 10.1021/tx010125x
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Plasma Cmax 894.53 nM 10.1021/jm300356u
Homo sapiens Plasma PPB 36.0 % 10.1016/j.ejmech.2016.09.022
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Prelamin-A/C Potency 631.0 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein-arginine deiminase type-4 IC50 10000000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Retinoid X receptor alpha Potency 4466.8 nM None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Serum Activity 50.0 % 10.1128/aac.01605-07
Homo sapiens Serum Cmax 1255.01 nM 10.1021/jm300356u
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Sodium channel protein type V alpha subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens TAR DNA-binding protein 43 Potency 4466.8 nM None
Homo sapiens THP-1 Activity 0.0 % 10.1021/jm300356u
Homo sapiens THP-1 Drug uptake 10.0 % 10.1128/aac.01723-09
Homo sapiens THP-1 Drug uptake nan None 10.1128/aac.00203-09
Homo sapiens THP-1 IC50 50000.0 nM 10.1021/jm2001585
Homo sapiens THP-1 Ratio 1.7 None 10.1128/aac.01723-09
Homo sapiens Thrombin AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 7943.3 nM None
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 23109.3 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Influenza A virus Influenza A virus EC50 68000.0 nM 10.1016/j.ejmech.2020.112739
Klebsiella oxytoca Klebsiella oxytoca Activity 90.0 % 10.1128/aac.00418-09
Klebsiella oxytoca Klebsiella oxytoca MIC 8.0 ug.mL-1 10.1128/aac.00418-09
Klebsiella oxytoca Klebsiella oxytoca MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Klebsiella oxytoca Klebsiella oxytoca MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 20.0 % 10.1128/aac.00471-08
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition nan % 10.1128/aac.00471-08
Klebsiella pneumoniae Klebsiella pneumoniae log10cfu nan None 10.1128/aac.00471-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.047 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.126 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.19 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1016/S0960-894X(00)80333-9
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmc.2016.06.044
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/S0960-894X(01)80238-9
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00405-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1021/np4006794
Klebsiella pneumoniae Klebsiella pneumoniae MIC 10000.0 nM 10.6019/CHEMBL4513141
Klebsiella pneumoniae Klebsiella pneumoniae MIC nan None 10.1128/aac.00471-08
Klebsiella pneumoniae Klebsiella pneumoniae Ratio 11.0 None 10.1128/aac.01439-09
Klebsiella pneumoniae Klebsiella pneumoniae Ratio 31.0 None 10.1128/aac.00405-08
Legionella pneumophila Legionella pneumophila Activity nan None 10.1128/aac.00418-09
Legionella pneumophila Legionella pneumophila MIC 0.01 ug.mL-1 10.1128/aac.00203-09
Legionella pneumophila Legionella pneumophila MIC 0.015 ug.mL-1 10.1128/aac.00418-09
Legionella pneumophila Legionella pneumophila MIC 0.016 ug.mL-1 10.1128/aac.00203-09
Legionella pneumophila Legionella pneumophila MIC 0.12 ug.mL-1 10.1128/aac.01315-06
Legionella pneumophila Legionella pneumophila MIC50 0.03 ug.mL-1 10.1128/aac.00418-09
Legionella pneumophila Legionella pneumophila MIC90 0.03 ug.mL-1 10.1128/aac.00418-09
Listeria monocytogenes Listeria monocytogenes Activity 2.9 mg/L 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes Activity 11.6 mg/L 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes Activity nan None 10.1128/aac.00418-09
Listeria monocytogenes Listeria monocytogenes EC50 2.66 ug.mL-1 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes EC50 2.86 ug.mL-1 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes log10cfu -0.83 None 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes log10cfu -0.81 None 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes MIC 0.25 ug.mL-1 10.1128/aac.00418-09
Listeria monocytogenes Listeria monocytogenes MIC 1.0 ug.mL-1 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes MIC nan None 10.1128/aac.00203-09
Listeria monocytogenes Listeria monocytogenes MIC50 0.5 ug.mL-1 10.1128/aac.00418-09
Listeria monocytogenes Listeria monocytogenes MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Metamycoplasma hominis Metamycoplasma hominis MIC 0.5 ug.mL-1 10.1128/aac.00090-09
Metamycoplasma hominis Metamycoplasma hominis MIC50 4.0 ug.mL-1 10.1128/aac.00090-09
Metamycoplasma hominis Metamycoplasma hominis MIC90 2.0 ug.mL-1 10.1128/aac.00090-09
Micrococcus luteus Micrococcus luteus MIC 2.0 ug.mL-1 10.1021/np4006794
Moraxella catarrhalis Moraxella catarrhalis Activity 100.0 % 10.1128/aac.00418-09
Moraxella catarrhalis Moraxella catarrhalis MBC 0.063 ug ml-1 10.1016/j.bmc.2019.115050
Moraxella catarrhalis Moraxella catarrhalis MBC 0.25 ug ml-1 10.1016/j.ejmech.2019.02.073
Moraxella catarrhalis Moraxella catarrhalis MIC 0.015 ug.mL-1 10.1128/aac.00418-09
Moraxella catarrhalis Moraxella catarrhalis MIC 0.016 ug.mL-1 10.1128/aac.01383-07
Moraxella catarrhalis Moraxella catarrhalis MIC 0.03 ug.mL-1 10.1128/aac.01383-07
Moraxella catarrhalis Moraxella catarrhalis MIC 0.031 ug.mL-1 10.1016/j.ejmech.2019.02.073
Moraxella catarrhalis Moraxella catarrhalis MIC 0.06 ug.mL-1 10.1016/j.ejmech.2012.01.039
Moraxella catarrhalis Moraxella catarrhalis MIC 0.06 ug.mL-1 10.1128/aac.01383-07
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.06.050
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.010
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.011
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2012.03.074
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2012.10.036
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmc.2019.115050
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2010.11.079
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.03.076
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2009.02.001
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1016/j.ejmech.2011.05.002
Moraxella catarrhalis Moraxella catarrhalis MIC 0.125 ug.mL-1 10.1021/jm300356u
Moraxella catarrhalis Moraxella catarrhalis MIC 0.25 ug.mL-1 10.1016/j.bmc.2010.10.024
Moraxella catarrhalis Moraxella catarrhalis MIC 0.25 ug.mL-1 10.1016/j.bmc.2015.10.042
Moraxella catarrhalis Moraxella catarrhalis MIC 0.25 ug.mL-1 10.1021/jm100711p
Moraxella catarrhalis Moraxella catarrhalis MIC 0.25 ug.mL-1 10.1021/ml100253p
Moraxella catarrhalis Moraxella catarrhalis MIC 8.0 ug.mL-1 10.1039/d2md00143h
Moraxella catarrhalis Moraxella catarrhalis MIC 16.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Moraxella catarrhalis Moraxella catarrhalis MIC nan None 10.1016/j.bmcl.2010.11.079
Moraxella catarrhalis Moraxella catarrhalis MIC50 0.015 ug.mL-1 10.1128/aac.00418-09
Moraxella catarrhalis Moraxella catarrhalis MIC50 0.015 ug.mL-1 10.1128/aac.01315-06
Moraxella catarrhalis Moraxella catarrhalis MIC50 0.12 ug.mL-1 10.1128/aac.00971-07
Moraxella catarrhalis Moraxella catarrhalis MIC90 0.03 ug.mL-1 10.1128/aac.00418-09
Moraxella catarrhalis Moraxella catarrhalis MIC90 0.03 ug.mL-1 10.1128/aac.01315-06
Moraxella catarrhalis Moraxella catarrhalis MIC90 0.12 ug.mL-1 10.1128/aac.00971-07
Moraxella catarrhalis Moraxella catarrhalis Selectivity ratio 8.0 None 10.1016/j.ejmech.2019.02.073
Morganella morganii Morganella morganii Activity 76.5 % 10.1128/aac.00418-09
Morganella morganii Morganella morganii MIC 8.0 ug.mL-1 10.1128/aac.00418-09
Morganella morganii Morganella morganii MIC 64.0 ug.mL-1 10.1021/np4006794
Morganella morganii Morganella morganii MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Morganella morganii Morganella morganii MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Mus musculus J774.A1 Activity 90.0 % 10.1128/aac.00375-07
Mus musculus Liver Stability 100.0 % 10.1016/j.ejmech.2016.09.022
Mus musculus Liver T1/2 2.0 hr 10.1021/jm2001585
Mus musculus MC-38 Activity 95.0 % 10.1128/aac.01142-06
Mus musculus Mus musculus Activity 0.42 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 2.24 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 2.37 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 4.31 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 5.25 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 7.44 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 12.4 day 10.1128/aac.00788-06
Mus musculus Mus musculus Activity 13.3 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 14.42 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 15.55 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 16.83 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 17.1 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 18.18 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 20.36 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 20.92 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 21.67 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 34.84 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 38.47 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity 40.0 % 10.1128/aac.00788-06
Mus musculus Mus musculus Activity 45.0 % 10.1128/aac.00788-06
Mus musculus Mus musculus Activity 46.16 % 10.1128/aac.01424-09
Mus musculus Mus musculus Activity nan None 10.1021/jm300356u
Mus musculus Mus musculus Activity nan None 10.1128/aac.01424-09
Mus musculus Mus musculus CL 16.0 mL.min-1.kg-1 10.1021/jm201615t
Mus musculus Mus musculus CL 23.2 mL.min-1.kg-1 10.1021/jm201615t
Mus musculus Mus musculus ED50 4.5 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 6.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 13.9 mg.kg-1 10.1021/jm020568d
Mus musculus Mus musculus ED50 15.7 mg.kg-1 10.1021/jm020568d
Mus musculus Mus musculus ED50 16.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 18.8 mg.kg-1 10.1021/jm0102349
Mus musculus Mus musculus ED50 24.8 mg.kg-1 10.1021/jm0102349
Mus musculus Mus musculus ED50 30.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 50.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 50.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 56.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 72.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 94.0 mg.kg-1 10.1016/s0960-894x(00)00392-9
Mus musculus Mus musculus ED50 94.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 100.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus ED50 145.0 mg.kg-1 10.1016/s0960-894x(99)00534-x
Mus musculus Mus musculus F 72.0 % 10.1021/jm201615t
Mus musculus Mus musculus PD50 16.0 mg kg-1 10.1021/jm960435q
Mus musculus Mus musculus PD50 16.0 mg kg-1 10.1021/jm960436i
Mus musculus Mus musculus Survival rate 50.0 % 10.1021/jm020568d
Mus musculus Mus musculus Survival rate 100.0 % 10.1021/jm020568d
Mus musculus Mus musculus T1/2 0.7333 hr 10.1128/aac.01011-06
Mus musculus Mus musculus T1/2 2.3 hr 10.1128/aac.01011-06
Mus musculus Mus musculus T1/2 8.3 hr 10.1021/jm201615t
Mus musculus Mus musculus Vdss 8.8 L.kg-1 10.1021/jm201615t
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Plasma Fu 0.0069 None 10.1021/jm201615t
Mus musculus Plasma PPB 27.0 % 10.1016/j.ejmech.2016.09.022
Mus musculus Serum Drug uptake 1.7 ug ml-1 10.1128/aac.01011-06
Mus musculus Serum Drug uptake 2.9 ug ml-1 10.1128/aac.01011-06
Mus musculus Serum Drug uptake 3.1 ug ml-1 10.1128/aac.01011-06
Mus musculus Transcription factor AP-1 Inhibition nan % 10.1021/jm300356u
Mycobacterium avium Mycobacterium avium Activity 1.0 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium Mycobacterium avium Activity 16.0 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium Mycobacterium avium MIC 4.0 ug.mL-1 10.1021/jm950956y
Mycobacterium avium Mycobacterium avium MIC 64.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 256.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 512.0 ug.mL-1 10.1016/j.ejmech.2017.09.014
Mycobacterium avium Mycobacterium avium MIC 512.0 ug.mL-1 10.1128/aac.01303-06
Mycobacterium avium Mycobacterium avium MIC50 16.0 ug.mL-1 10.1128/aac.01303-06
Mycobacterium avium Mycobacterium avium MIC90 16.0 ug.mL-1 10.1128/aac.01303-06
Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis Activity 0.5 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis Activity 1.0 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis Activity 2.0 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis Activity 4.0 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis Activity 16.0 ug ml-1 10.1128/aac.00678-07
Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis Activity nan None 10.1128/aac.00678-07
Mycobacterium malmoense Mycobacterium malmoense MIC 16.0 ug.mL-1 10.1021/jm950956y
Mycobacterium simiae Mycobacterium simiae MIC 4.0 ug.mL-1 10.1021/jm950956y
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 1.0 ug.mL-1 10.1128/aac.01302-08
Mycobacterium tuberculosis variant bovis Mycobacterium tuberculosis variant bovis MIC 16.0 ug.mL-1 10.1128/aac.01302-08
Mycobacterium xenopi Mycobacterium xenopi MIC 1.0 ug.mL-1 10.1021/jm950956y
Mycobacteroides abscessus Mycobacteroides abscessus MIC50 0.5 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides abscessus Mycobacteroides abscessus MIC90 2.0 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC 500.0 ug.mL-1 10.1128/aac.00590-09
Mycobacteroides chelonae Mycobacteroides chelonae MIC50 0.5 ug.mL-1 10.1128/aac.00695-08
Mycobacteroides chelonae Mycobacteroides chelonae MIC90 16.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC 64.0 ug.mL-1 10.1021/jm950956y
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC50 8.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium fortuitum Mycolicibacterium fortuitum MIC90 64.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium mageritense Mycolicibacterium mageritense MIC 2.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC50 0.5 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium peregrinum Mycolicibacterium peregrinum MIC90 64.0 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 0.06 ug.mL-1 10.1128/aac.00695-08
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 4000.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 1.6e-05 ug.mL-1 10.1128/aac.00090-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.00024 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.001 ug.mL-1 10.1128/aac.00746-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.001 ug.mL-1 10.1128/aac.00849-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.001 ug.mL-1 10.1128/aac.01563-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.004 ug.mL-1 10.1128/aac.01315-06
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 0.007 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.00025 ug.mL-1 10.1128/aac.00090-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.00049 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.001 ug.mL-1 10.1128/aac.00746-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 0.001 ug.mL-1 10.1128/aac.00849-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 16.0 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 32.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC50 128.0 ug.mL-1 10.1128/aac.01563-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.0005 ug.mL-1 10.1128/aac.00090-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.00098 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.001 ug.mL-1 10.1128/aac.00849-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 0.016 ug.mL-1 10.1128/aac.00746-09
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.00779-07
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01684-08
Mycoplasmoides pneumoniae Mycoplasmoides pneumoniae MIC90 256.0 ug.mL-1 10.1128/aac.01563-08
Naegleria fowleri Naegleria fowleri FIC50 0.088 None 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri FIC50 0.103 None 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri FIC50 0.238 None 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri FIC50 0.308 None 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri FIC50 0.464 None 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri FIC50 0.55 None 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri IC50 2.6 nM 10.1128/aac.00788-06
Naegleria fowleri Naegleria fowleri IC50 3.1 nM 10.1128/aac.00788-06
Neisseria gonorrhoeae Neisseria gonorrhoeae Activity 5.7 % 10.1128/aac.00235-10
Neisseria gonorrhoeae Neisseria gonorrhoeae Activity 80.0 % 10.1128/aac.00235-10
Neisseria gonorrhoeae Neisseria gonorrhoeae Activity nan None 10.1128/aac.00235-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 0.06 ug.mL-1 10.1128/aac.00309-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 0.06 ug.mL-1 10.1128/aac.01506-09
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 0.25 ug.mL-1 10.1128/aac.00309-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 0.25 ug.mL-1 10.1128/aac.00788-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 0.38 ug.mL-1 10.1128/aac.00309-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 1.5 ug.mL-1 10.1128/aac.00309-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 2.0 ug.mL-1 10.1128/aac.00309-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 4.0 ug.mL-1 10.1128/aac.01506-09
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 8.0 ug.mL-1 10.1128/aac.01506-09
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 256.0 ug.mL-1 10.1128/aac.00309-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 2048.0 ug.mL-1 10.1128/aac.01506-09
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC50 0.06 ug.mL-1 10.1128/aac.01315-06
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC50 0.25 ug.mL-1 10.1128/aac.00235-10
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC90 0.12 ug.mL-1 10.1128/aac.01315-06
Neisseria meningitidis Neisseria meningitidis Activity 100.0 % 10.1128/aac.00418-09
Neisseria meningitidis Neisseria meningitidis Activity 100.0 % 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC 0.015 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC 0.03 ug.mL-1 10.1128/aac.00418-09
Neisseria meningitidis Neisseria meningitidis MIC 0.125 ug.mL-1 10.1128/aac.01168-09
Neisseria meningitidis Neisseria meningitidis MIC 2.0 ug.mL-1 10.1128/aac.01168-09
Neisseria meningitidis Neisseria meningitidis MIC50 0.06 ug.mL-1 10.1128/aac.00418-09
Neisseria meningitidis Neisseria meningitidis MIC50 0.06 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC50 0.5 ug.mL-1 10.1128/aac.01315-06
Neisseria meningitidis Neisseria meningitidis MIC90 0.06 ug.mL-1 10.1128/aac.00418-09
Neisseria meningitidis Neisseria meningitidis MIC90 0.12 ug.mL-1 10.1128/aac.01812-09
Neisseria meningitidis Neisseria meningitidis MIC90 1.0 ug.mL-1 10.1128/aac.01315-06
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Pasteurella multocida Pasteurella multocida Activity nan None 10.1021/jm960294s
Pasteurella multocida Pasteurella multocida MIC 0.05 ug.mL-1 10.1021/jm960435q
Pasteurella multocida Pasteurella multocida MIC 0.05 ug.mL-1 10.1021/jm960436i
Pasteurella multocida Pasteurella multocida MIC 0.1 ug.mL-1 10.1016/s0960-894x(02)00434-1
Pasteurella multocida Pasteurella multocida MIC 100.0 ug.mL-1 10.1021/acs.jmedchem.1c00790
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC50 0.5 ug.mL-1 10.1128/aac.00056-07
Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC90 1.0 ug.mL-1 10.1128/aac.00056-07
Plasmodium berghei Plasmodium berghei Activity nan None 10.1021/jm2001585
Plasmodium berghei Plasmodium berghei Activity nan None 10.1021/jm201615t
Plasmodium berghei Plasmodium berghei Activity nan None 10.1021/jm301678j
Plasmodium berghei Plasmodium berghei CD50 50.0 mg kg-1 10.1021/jm2001585
Plasmodium berghei Plasmodium berghei Survival 17.0 day 10.1021/jm201615t
Plasmodium berghei Plasmodium berghei Survival 19.0 day 10.1021/jm201615t
Plasmodium falciparum Plasmodium falciparum Activity 17.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 18.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 28.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 30.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 59.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 61.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 68.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 79.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 83.4 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 91.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 105.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity 113.0 % 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity nan None 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum Activity nan None 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 0.5 ug.mL-1 10.1021/jm2001585
Plasmodium falciparum Plasmodium falciparum IC50 1.623 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 1.848 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 1.976 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC50 2.19 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC50 2.444 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC50 2.57 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC50 2.734 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 3.747 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 4.489 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 5.342 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC50 5.5 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 10.07 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 10.13 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 14.36 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 15.28 ug.mL-1 10.1128/aac.01607-06
Plasmodium falciparum Plasmodium falciparum IC50 31.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 43.3 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 47.8 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 48.0 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 52.7 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 53.0 nM 10.1021/acs.jmedchem.5b01485
Plasmodium falciparum Plasmodium falciparum IC50 63.3 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 66.7 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 70.2 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 76.7 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 95.7 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 103.4 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 114.8 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 121.8 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 141.8 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 154.7 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 157.9 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 180.3 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 194.2 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 228.1 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 410.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 940.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 1015.0 nM 10.1016/j.bmc.2011.01.030
Plasmodium falciparum Plasmodium falciparum IC50 1039.0 nM 10.1021/jm2001585
Plasmodium falciparum Plasmodium falciparum IC50 1460.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 1938.7 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 2065.0 nM 10.1016/j.bmc.2011.01.030
Plasmodium falciparum Plasmodium falciparum IC50 2112.0 nM 10.1021/jm2001585
Plasmodium falciparum Plasmodium falciparum IC50 2241.0 nM 10.1016/j.bmc.2011.01.030
Plasmodium falciparum Plasmodium falciparum IC50 2294.0 nM 10.1021/jm2001585
Plasmodium falciparum Plasmodium falciparum IC50 2654.0 nM 10.1021/jm201615t
Plasmodium falciparum Plasmodium falciparum IC50 2680.0 nM 10.1016/j.ejmech.2012.01.039
Plasmodium falciparum Plasmodium falciparum IC50 2680.0 nM 10.1021/jm201676t
Plasmodium falciparum Plasmodium falciparum IC50 3464.0 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 3971.7 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 4314.35 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum IC50 4570.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 6500.0 nM 10.1021/acs.jmedchem.5b01485
Plasmodium falciparum Plasmodium falciparum IC50 8670.0 nM 10.1128/aac.00527-07
Plasmodium falciparum Plasmodium falciparum IC50 8700.0 nM 10.1021/acs.jmedchem.5b01485
Plasmodium falciparum Plasmodium falciparum IC50 9040.0 nM 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum IC50 11513.0 nM 10.1016/j.ejmech.2012.01.039
Plasmodium falciparum Plasmodium falciparum IC50 11513.0 nM 10.1021/jm201676t
Plasmodium falciparum Plasmodium falciparum IC50 15742.0 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC50 22585.0 nM 10.1074/jbc.m608615200
Plasmodium falciparum Plasmodium falciparum IC90 13.31 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC90 18420.58 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum IC99 23.95 ug.mL-1 10.1128/aac.01023-06
Plasmodium falciparum Plasmodium falciparum IC99 26745.2 nM 10.1128/aac.00312-09
Plasmodium falciparum Plasmodium falciparum Potency 134.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 13459.1 nM None
Plasmodium falciparum Plasmodium falciparum Ratio IC50 10.0 None 10.1128/aac.00892-07
Plasmodium falciparum Plasmodium falciparum Ratio IC50 88.0 None 10.1021/jm2001585
Plasmodium vivax Plasmodium vivax Activity 58.0 % 10.1021/jm201095h
Plasmodium yoelii Plasmodium yoelii Efficacy 40.0 % 10.1021/jm201095h
Plasmodium yoelii Plasmodium yoelii Efficacy 80.0 % 10.1021/jm201095h
Plasmodium yoelii Plasmodium yoelii Efficacy 100.0 % 10.1021/jm201095h
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 1.0 None 10.1128/aac.00613-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 4.0 None 10.1128/aac.00613-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 10.0 ug ml-1 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 24.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 27.0 % 10.1016/j.ejmech.2022.114457
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 31.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 31.2 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 32.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 43.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 67.4 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 87.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 88.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 99.0 % 10.1016/j.ejmech.2022.114457
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 99.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 103.0 ug ml-1 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 143.0 ug ml-1 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity 316.0 ug ml-1 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1128/aac.00613-07
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1128/aac.01424-09
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 0.0 ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 2.0 10'3/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 2.5 10'2/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 3.8 10'7/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 8.6 10'5/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 31.0 10'6/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 50.0 None 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 55.0 10'6/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa CFU 110.0 10'5/ml 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 1.0 None 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 44.3 None 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 50.0 None 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa FC 5000.0 None 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa GI nan None 10.1021/np100472d
Pseudomonas aeruginosa Pseudomonas aeruginosa IC50 7100.0 nM 10.1021/acs.jmedchem.1c01781
Pseudomonas aeruginosa Pseudomonas aeruginosa INH 16.0 ug ml-1 10.1016/j.bmc.2019.115229
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition -73.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition -70.2 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition -63.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition -30.9 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 10.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 15.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 16.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 20.0 % 10.1128/aac.00471-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 32.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 37.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 43.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 45.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 48.0 % 10.1016/j.ejmech.2022.114457
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 51.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 52.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 56.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 63.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 65.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 66.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 70.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 77.0 % 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 78.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 85.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 90.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 99.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 100.0 % 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition nan % 10.1016/j.ejmech.2022.114457
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition nan % 10.1128/aac.00471-08
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition nan % 10.1128/aac.00613-07
Pseudomonas aeruginosa Pseudomonas aeruginosa log10cfu 2.0 None 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa log10cfu 4.0 None 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa log10cfu nan None 10.1128/aac.00471-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1016/j.bmcl.2015.05.070
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.bmcl.2010.12.111
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.25 ug.mL-1 10.1016/j.ejmech.2018.12.017
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.25 ug.mL-1 10.1128/aac.00511-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2010.12.111
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 128.0 ug.mL-1 10.1128/aac.01264-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1021/np4006794
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1128/aac.01011-06
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10000.0 nM 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 85400.0 nM 10.1016/j.ejmech.2022.114629
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1128/aac.00471-08
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 16.0 ug.mL-1 10.1021/acs.jmedchem.7b00377
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 128.0 ug.mL-1 10.1021/acs.jmedchem.7b00377
Pseudomonas aeruginosa Pseudomonas aeruginosa SubMIC 20.1 uM 10.1016/j.ejmech.2022.114629
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver Stability 100.0 % 10.1016/j.ejmech.2016.09.022
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Plasma Fu 0.88 None 10.1021/jm901371v
Rattus norvegicus Plasma PPB 28.0 % 10.1016/j.ejmech.2016.09.022
Rattus norvegicus Rattus norvegicus ALB 38000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 38700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 39700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 41200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 239.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 321.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 324.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 346.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 356.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 367.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 45.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 52.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 55.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 77.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 81.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 85.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 88.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 92.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 97.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 110.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 116.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 126.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 130.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 133.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 97.8 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 651.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 663.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 675.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 746.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 806.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 830.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 196.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 211.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 222.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 358.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 375.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 511.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CL 11.0 mL.min-1.kg-1 10.1021/jm2001585
Rattus norvegicus Rattus norvegicus CO2 29830000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 30000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 31670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 33670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 34670000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.4 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.9 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 33.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 44.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 48.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 59.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 33.0 % 10.1021/jm2001585
Rattus norvegicus Rattus norvegicus GLUC 1436.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1523.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1530.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1550.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1646.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1650.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.62 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.47 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.53 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.2 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.9 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 128300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 129000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 133300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 134700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 139000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 143.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 154.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 163.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 164.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 176.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 180.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 10.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 11.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 12.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6230.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 8956.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9267.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11257.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 13483.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 14976.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 92.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.8 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.33 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.5 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.67 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 25.73 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 375300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 384500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 386700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 393500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.23 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.83 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 65.87 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.63 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 66.97 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 50.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 72.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 157.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 159.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 194.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 252.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 5.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 6.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 7.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 10.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 476.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 561.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 572.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1020.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1220.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1373.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 99.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 106.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 108.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 113.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 114.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1013330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1023330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1122330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1159000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1162500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1180330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.69 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.91 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.99 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.08 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.42 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 7.13 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 54300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 56500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 58700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5000000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5030000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5240000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5350000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5410000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5440000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.33 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.67 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.54 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.85 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.3 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.1 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 24.0 hr 10.1021/jm2001585
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 3.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 5.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 8.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 10.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Vd/F 20.0 L.kg-1 10.1021/jm2001585
Rattus norvegicus Rattus norvegicus WBC 6870.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9730.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 10080.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12580.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14800.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 16400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Salmonella enterica Salmonella enterica INH 16.0 ug ml-1 10.1016/j.bmc.2019.115229
Salmonella enterica Salmonella enterica MIC 32.0 ug.mL-1 10.1128/aac.01678-09
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC 128.0 ug.mL-1 10.1128/aac.01678-09
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC 2.0 ug.mL-1 10.1016/j.bmcl.2015.05.070
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.11.028
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.5 ug.mL-1 10.1016/j.ejmech.2012.11.028
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 128.0 ug.mL-1 10.1128/aac.01678-09
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition -2.537 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 AUC 249.1 None 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 EC50 2120.0 nM 10.1016/j.ejmech.2020.112739
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 EC50 2120.0 nM 10.1101/2020.04.03.023846
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 EC90 8.65 uM 10.1016/j.ejmech.2020.112739
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 EC90 8.65 uM 10.1101/2020.04.03.023846
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.3754 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 7762471.17 nM 10.1038/s41586-020-2286-9
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -1.27 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.08 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 1.487 None 10.1101/2020.04.03.023846
Staphylococcus Staphylococcus MIC 0.03 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus Staphylococcus MIC 0.25 ug.mL-1 10.1128/aac.01383-07
Staphylococcus Staphylococcus MIC 1.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus Staphylococcus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus Staphylococcus MIC 128.0 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus Staphylococcus MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus Staphylococcus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2009.04.030
Staphylococcus aureus Staphylococcus aureus Activity 0.29 mg/L 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus Activity 0.63 mg/L 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus Activity 18.2 % 10.1128/aac.00418-09
Staphylococcus aureus Staphylococcus aureus Activity 94.7 % 10.1128/aac.00418-09
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acsmedchemlett.1c00648
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1128/aac.01605-07
Staphylococcus aureus Staphylococcus aureus EC50 0.024 ug.mL-1 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus EC50 0.12 ug.mL-1 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus ED50 4.1 mg.kg-1 10.1016/s0960-894x(02)00434-1
Staphylococcus aureus Staphylococcus aureus ED50 24.8 mg.kg-1 10.1021/jm990618n
Staphylococcus aureus Staphylococcus aureus ED50 60.0 mg.kg-1 10.1021/jm980240d
Staphylococcus aureus Staphylococcus aureus ED50 100.0 mg.kg-1 10.1021/jm980240d
Staphylococcus aureus Staphylococcus aureus FC 0.22 None 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus FC 226.0 None 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus Inhibition nan % 10.1128/aac.00471-08
Staphylococcus aureus Staphylococcus aureus log10cfu -1.0 None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus log10cfu -0.29 None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus log10cfu 9.75 None 10.1128/aac.00471-08
Staphylococcus aureus Staphylococcus aureus Log CFU 2.8 None 10.1016/s0960-894x(02)00434-1
Staphylococcus aureus Staphylococcus aureus MBC 32.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus MBC 32.0 ug ml-1 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus MBC 256.0 ug ml-1 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus MBC nan None 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus MIC 0.0003 ug.mL-1 10.1128/aac.00471-08
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2010.11.035
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2011.04.004
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1016/j.ejmech.2011.08.001
Staphylococcus aureus Staphylococcus aureus MIC 0.2 ug.mL-1 10.1016/s0960-894x(02)00434-1
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2017.06.044
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2017.07.017
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.06.006
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2018.09.012
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2019.126850
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128110
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.bmcl.2021.128330
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2009.11.032
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2010.11.035
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2011.08.001
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.11.028
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.10.065
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.07.022
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00550-07
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 0.256 ug.mL-1 10.1128/aac.01173-08
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1016/s0960-894x(00)00392-9
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1016/s0960-894x(98)00402-8
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1016/s0960-894x(99)00534-x
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1021/jm980240d
Staphylococcus aureus Staphylococcus aureus MIC 0.39 ug.mL-1 10.1021/jm020568d
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmc.2010.06.048
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmc.2010.06.050
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmc.2011.07.010
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmc.2011.07.011
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmc.2012.10.036
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2010.03.038
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2010.04.062
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.bmcl.2010.11.079
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2009.02.001
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2010.05.008
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2010.05.009
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2011.05.002
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/j.ejmech.2012.11.028
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1016/S0960-894X(00)80333-9
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/jm201676t
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/jm300356u
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1021/np060334n
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00418-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00550-07
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01605-07
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1021/jm0102349
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1021/jm020568d
Staphylococcus aureus Staphylococcus aureus MIC 0.78 ug.mL-1 10.1021/jm990618n
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2012.03.074
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmc.2016.06.044
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2005.01.027
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2012.03.076
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2011.08.001
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.01.039
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/S0960-894X(01)80238-9
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm100711p
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/ml100253p
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/ml500279k
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmc.2015.10.042
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.bmcl.2015.05.070
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/np4006794
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1039/d2md00143h
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/j.ejmech.2018.12.017
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus MIC 40.0 ug.mL-1 10.1016/s0960-894x(00)00392-9
Staphylococcus aureus Staphylococcus aureus MIC 40.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Staphylococcus aureus Staphylococcus aureus MIC 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2005.01.027
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.03.038
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/jm100711p
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/ml100253p
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/ml500279k
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1021/jm020568d
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus aureus Staphylococcus aureus MIC 200.0 ug.mL-1 10.1021/acs.jmedchem.1c00790
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2010.03.038
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128330
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1021/np4006794
Staphylococcus aureus Staphylococcus aureus MIC 500.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Staphylococcus aureus Staphylococcus aureus MIC 500.0 ug.mL-1 10.1016/s0960-894x(98)00227-3
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 ug.mL-1 10.1007/s00044-013-0844-5
Staphylococcus aureus Staphylococcus aureus MIC 10000.0 nM 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1128/aac.00203-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.13 ug.mL-1 10.1016/j.bmc.2015.04.078
Staphylococcus aureus Staphylococcus aureus MIC50 0.78 ug.mL-1 10.1016/j.bmc.2015.04.078
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00550-07
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.01315-06
Staphylococcus aureus Staphylococcus aureus MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus aureus Staphylococcus aureus MIC50 8.0 ug.mL-1 10.1128/aac.01315-06
Staphylococcus aureus Staphylococcus aureus MIC50 64.0 ug.mL-1 10.1128/aac.00550-07
Staphylococcus aureus Staphylococcus aureus MIC50 nan None 10.1016/j.bmc.2015.04.078
Staphylococcus aureus Staphylococcus aureus MIC80 2.0 ug.mL-1 10.1016/j.bmcl.2013.07.042
Staphylococcus aureus Staphylococcus aureus MIC80 16.0 ug.mL-1 10.1016/j.bmcl.2013.07.042
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.00567-09
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1128/aac.01315-06
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1128/aac.00550-07
Staphylococcus aureus Staphylococcus aureus MIC90 128.0 ug.mL-1 10.1021/jm500462x
Staphylococcus aureus Staphylococcus aureus Ratio 1.0 None 10.1016/j.ejmech.2020.112222
Staphylococcus aureus Staphylococcus aureus Ratio 6.0 None 10.1016/j.bmc.2015.04.078
Staphylococcus aureus Staphylococcus aureus Ratio 64.0 None 10.1016/j.ejmech.2016.09.022
Staphylococcus aureus Staphylococcus aureus Selectivity ratio 1.0 None 10.1016/j.ejmech.2019.02.073
Staphylococcus capitis Staphylococcus capitis MIC 64.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus epidermidis Staphylococcus epidermidis Activity 0.0 % 10.1128/aac.00418-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 2.5 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 33.4 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 37.6 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 39.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 47.0 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 48.1 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 49.1 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 56.4 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 57.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 58.4 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 59.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 71.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 75.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 92.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 100.0 % 10.1128/aac.00418-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 104.0 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 117.2 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 128.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 157.9 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 184.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 277.8 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 289.2 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis Activity 298.3 % 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1016/j.ejmech.2016.10.065
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1016/S0960-894X(00)80333-9
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1128/aac.00418-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 2.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Staphylococcus epidermidis Staphylococcus epidermidis MIC 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1128/aac.01565-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Staphylococcus epidermidis Staphylococcus epidermidis MIC 256.0 ug.mL-1 10.1021/np4006794
Staphylococcus epidermidis Staphylococcus epidermidis MIC nan None 10.1021/np4006794
Staphylococcus epidermidis Staphylococcus epidermidis MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC90 nan None 10.1128/aac.00418-09
Staphylococcus haemolyticus Staphylococcus haemolyticus Activity 39.6 % 10.1128/aac.00418-09
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC 0.25 ug.mL-1 10.1128/aac.00418-09
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus haemolyticus Staphylococcus haemolyticus MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus hominis Staphylococcus hominis Activity 30.0 % 10.1128/aac.00418-09
Staphylococcus hominis Staphylococcus hominis MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Staphylococcus hominis Staphylococcus hominis MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Staphylococcus hominis Staphylococcus hominis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Staphylococcus hominis Staphylococcus hominis MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Staphylococcus hominis Staphylococcus hominis MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus hominis Staphylococcus hominis MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus lugdunensis Staphylococcus lugdunensis Activity 66.7 % 10.1128/aac.00418-09
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC 0.25 ug.mL-1 10.1128/aac.00418-09
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus saprophyticus Staphylococcus saprophyticus Activity 100.0 % 10.1128/aac.00418-09
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus saprophyticus Staphylococcus saprophyticus MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus sp. Staphylococcus sp. MIC50 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus sp. Staphylococcus sp. MIC50 nan ug.mL-1 10.1021/jm980240d
Staphylococcus sp. Staphylococcus sp. MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Staphylococcus sp. Staphylococcus sp. MIC90 40.0 ug.mL-1 10.1021/jm980240d
Staphylococcus sp. Staphylococcus sp. MIC90 nan ug.mL-1 10.1021/jm980240d
Staphylococcus warneri Staphylococcus warneri Activity 76.0 % 10.1128/aac.00418-09
Staphylococcus warneri Staphylococcus warneri MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Staphylococcus warneri Staphylococcus warneri MIC50 8.0 ug.mL-1 10.1128/aac.00418-09
Staphylococcus warneri Staphylococcus warneri MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus Streptococcus EC50 66.0 nM None
Streptococcus agalactiae Streptococcus agalactiae Activity 98.0 % 10.1128/aac.00418-09
Streptococcus agalactiae Streptococcus agalactiae MIC 0.25 ug.mL-1 10.1128/aac.00418-09
Streptococcus agalactiae Streptococcus agalactiae MIC 32.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Streptococcus agalactiae Streptococcus agalactiae MIC50 0.5 ug.mL-1 10.1128/aac.00418-09
Streptococcus agalactiae Streptococcus agalactiae MIC90 0.5 ug.mL-1 10.1128/aac.00418-09
Streptococcus constellatus Streptococcus constellatus Activity 0.0 % 10.1128/aac.01845-09
Streptococcus constellatus Streptococcus constellatus Activity 7.7 % 10.1128/aac.01845-09
Streptococcus constellatus Streptococcus constellatus Activity 20.0 % 10.1128/aac.01845-09
Streptococcus constellatus Streptococcus constellatus Activity 65.0 % 10.1128/aac.01845-09
Streptococcus constellatus Streptococcus constellatus Activity nan None 10.1128/aac.00418-09
Streptococcus constellatus Streptococcus constellatus MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus constellatus Streptococcus constellatus MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus constellatus Streptococcus constellatus MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus dysgalactiae Streptococcus dysgalactiae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus equinus Streptococcus equinus Activity nan None 10.1128/aac.00418-09
Streptococcus equinus Streptococcus equinus MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus equinus Streptococcus equinus MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus equinus Streptococcus equinus MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus intermedius Streptococcus intermedius Activity 16.7 % 10.1128/aac.01845-09
Streptococcus intermedius Streptococcus intermedius Activity 28.6 % 10.1128/aac.01845-09
Streptococcus intermedius Streptococcus intermedius Activity 34.4 % 10.1128/aac.01845-09
Streptococcus intermedius Streptococcus intermedius Activity 50.0 % 10.1128/aac.01845-09
Streptococcus intermedius Streptococcus intermedius Activity nan None 10.1128/aac.00418-09
Streptococcus intermedius Streptococcus intermedius MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus intermedius Streptococcus intermedius MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus intermedius Streptococcus intermedius MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus mitis Streptococcus mitis Activity nan None 10.1128/aac.00418-09
Streptococcus mitis Streptococcus mitis MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus mitis Streptococcus mitis MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus mitis Streptococcus mitis MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus oralis Streptococcus oralis Activity nan None 10.1128/aac.00418-09
Streptococcus oralis Streptococcus oralis MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus oralis Streptococcus oralis MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus oralis Streptococcus oralis MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 0.0 % 10.1128/aac.01268-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 0.5 ug ml-1 10.1128/aac.00157-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 2.0 ug ml-1 10.1128/aac.00157-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 11.3 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 19.4 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 20.8 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 27.6 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 31.2 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 33.0 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 33.8 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 34.0 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 34.8 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 35.5 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 36.0 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 36.5 % 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 37.7 % 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 42.4 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 50.5 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 62.3 % 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 62.5 % 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 64.5 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 65.5 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 74.3 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 77.6 % 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 80.6 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 87.9 % 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 100.0 % 10.1128/aac.00157-07
Streptococcus pneumoniae Streptococcus pneumoniae Activity 100.0 % 10.1128/aac.01268-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1016/j.bmcl.2009.06.023
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae ED50 6.0 mg.kg-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae ED50 18.8 mg.kg-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae ED50 50.0 mg.kg-1 10.1021/jm980240d
Streptococcus pneumoniae Streptococcus pneumoniae ED50 78.7 mg.kg-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae ED50 100.0 mg.kg-1 10.1021/jm980240d
Streptococcus pneumoniae Streptococcus pneumoniae ED50 100.0 mg.kg-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae IC50 170.0 nM 10.1021/jm0102349
Streptococcus pneumoniae Streptococcus pneumoniae IC50 500000.0 nM 10.1021/jm0102349
Streptococcus pneumoniae Streptococcus pneumoniae MBC 0.25 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MBC 0.25 ug ml-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MBC 16.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MBC 16.0 ug ml-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MBC 256.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MBC 257.0 ug ml-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.008 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.015 ug.mL-1 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.016 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmc.2016.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmc.2016.07.029
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2011.08.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1016/S0960-894X(01)80238-9
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.03 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/j.ejmech.2012.01.039
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1016/S0960-894X(00)80333-9
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.06 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.062 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.062 ug.mL-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.064 ug.mL-1 10.1016/j.bmcl.2010.03.038
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.064 ug.mL-1 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.1 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1021/jm0102349
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.12 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2012.03.074
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2005.01.027
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2010.11.079
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.03.076
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.ejmech.2009.02.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.09.022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1021/jm100711p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1021/jm201676t
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1021/jm300356u
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1021/ml100253p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1021/ml500279k
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1039/d2md00143h
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.125 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.13 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.15 ug.mL-1 10.1016/s0960-894x(00)00392-9
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.15 ug.mL-1 10.1016/s0960-894x(98)00402-8
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.15 ug.mL-1 10.1016/s0960-894x(99)00534-x
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.15 ug.mL-1 10.1021/jm980240d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.bmc.2015.10.042
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1039/C4MD00489B
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01153-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.25 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1016/j.ejmech.2010.05.009
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.78 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1039/C4MD00489B
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmc.2020.115776
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01268-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.05.009
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2011.08.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1021/jm100711p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1021/ml100253p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1021/ml500279k
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1021/np060334n
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00157-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2005.01.027
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.bmcl.2018.11.038
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1039/C4MD00489B
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1039/d2md00143h
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 16.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1016/s0960-894x(00)00392-9
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1016/s0960-894x(98)00402-8
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1016/s0960-894x(99)00534-x
Streptococcus pneumoniae Streptococcus pneumoniae MIC 40.0 ug.mL-1 10.1021/jm980240d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 60.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Streptococcus pneumoniae Streptococcus pneumoniae MIC 60.0 ug.mL-1 10.1016/s0960-894x(98)00227-3
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2005.01.027
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1021/jm100711p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1021/ml100253p
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1021/ml500279k
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.00827-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC 100.0 ug.mL-1 10.1021/jm020568d
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2010.03.038
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2011.08.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1021/jm990618n
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2009.01.092
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2010.04.051
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2011.04.004
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2011.08.001
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01153-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC nan None 10.1016/j.ejmech.2010.05.008
Streptococcus pneumoniae Streptococcus pneumoniae MIC nan None 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.06 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.12 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.12 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.12 ug.mL-1 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.12 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.125 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 0.125 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01268-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.00157-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01315-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 8.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 32.0 ug.mL-1 10.1021/jm301650g
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 32.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 64.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 128.0 ug.mL-1 10.1016/j.bmc.2020.115776
Streptococcus pneumoniae Streptococcus pneumoniae MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Streptococcus pneumoniae Streptococcus pneumoniae MIC80 4.0 ug.mL-1 10.1016/j.bmcl.2013.07.042
Streptococcus pneumoniae Streptococcus pneumoniae MIC80 8.0 ug.mL-1 10.1016/j.bmcl.2013.07.042
Streptococcus pneumoniae Streptococcus pneumoniae MIC80 32.0 ug.mL-1 10.1021/jm301650g
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.0125 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.12 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.12 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.12 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.125 ug.mL-1 10.1128/aac.00567-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 0.5 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 1.0 ug.mL-1 10.1128/aac.00567-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 2.0 ug.mL-1 10.1128/aac.01268-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.00157-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 7.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01315-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 16.0 ug.mL-1 10.1128/aac.00971-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 27.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 29.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 31.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 32.0 ug.mL-1 10.1021/jm301650g
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 36.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 42.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01229-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01531-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 69.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 71.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 73.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 79.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 93.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 100.0 ug.mL-1 10.1128/aac.00310-08
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 128.0 ug.mL-1 10.1016/j.bmc.2020.115776
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 128.0 ug.mL-1 10.1128/aac.01548-09
Streptococcus pneumoniae Streptococcus pneumoniae MST 5.84 day 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae MST 7.33 day 10.1128/aac.01459-06
Streptococcus pneumoniae Streptococcus pneumoniae PD50 3.31 mg kg-1 10.1016/j.bmc.2016.07.029
Streptococcus pneumoniae Streptococcus pneumoniae Post Antibiotic Effe 3.1 hr 10.1128/aac.01150-06
Streptococcus pneumoniae Streptococcus pneumoniae Ratio 2.0 None 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae Ratio 4.0 None 10.1016/j.ejmech.2020.112222
Streptococcus pneumoniae Streptococcus pneumoniae Selectivity ratio 2.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pneumoniae Streptococcus pneumoniae Selectivity ratio 4.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes Activity 0.5 % 10.1128/aac.00418-09
Streptococcus pyogenes Streptococcus pyogenes Activity 11.6 % 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes Activity 81.1 % 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes Activity nan None 10.1016/j.bmcl.2009.06.023
Streptococcus pyogenes Streptococcus pyogenes ED50 6.1 mg.kg-1 10.1021/jm990618n
Streptococcus pyogenes Streptococcus pyogenes ED50 16.0 mg.kg-1 10.1021/jm980240d
Streptococcus pyogenes Streptococcus pyogenes Inhibition 20.0 % 10.1128/aac.00471-08
Streptococcus pyogenes Streptococcus pyogenes Inhibition nan % 10.1128/aac.00471-08
Streptococcus pyogenes Streptococcus pyogenes log10cfu 8.24 None 10.1128/aac.00471-08
Streptococcus pyogenes Streptococcus pyogenes MBC 16.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MBC 64.0 ug ml-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MIC 0.00025 ug.mL-1 10.1128/aac.00471-08
Streptococcus pyogenes Streptococcus pyogenes MIC 0.008 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1128/aac.00418-09
Streptococcus pyogenes Streptococcus pyogenes MIC 0.03 ug.mL-1 10.1128/aac.01383-07
Streptococcus pyogenes Streptococcus pyogenes MIC 0.06 ug.mL-1 10.1016/S0960-894X(00)80333-9
Streptococcus pyogenes Streptococcus pyogenes MIC 0.06 ug.mL-1 10.1021/jm990618n
Streptococcus pyogenes Streptococcus pyogenes MIC 0.06 ug.mL-1 10.1128/aac.01383-07
Streptococcus pyogenes Streptococcus pyogenes MIC 0.12 ug.mL-1 10.1016/j.ejmech.2009.11.032
Streptococcus pyogenes Streptococcus pyogenes MIC 0.12 ug.mL-1 10.1021/jm990618n
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2012.03.074
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmc.2015.10.042
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmcl.2005.01.027
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmcl.2010.11.079
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.03.076
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.ejmech.2009.02.001
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.ejmech.2012.01.039
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1016/j.ejmech.2016.09.022
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1021/jm100711p
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1021/jm201676t
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1021/jm300356u
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1021/ml100253p
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1021/ml500279k
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1039/d2md00143h
Streptococcus pyogenes Streptococcus pyogenes MIC 0.125 ug.mL-1 10.1128/aac.01383-07
Streptococcus pyogenes Streptococcus pyogenes MIC 0.13 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pyogenes Streptococcus pyogenes MIC 0.25 ug.mL-1 10.1016/j.bmcl.2011.10.101
Streptococcus pyogenes Streptococcus pyogenes MIC 0.25 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes MIC 0.6 ug.mL-1 10.1016/s0960-894x(00)00392-9
Streptococcus pyogenes Streptococcus pyogenes MIC 0.6 ug.mL-1 10.1016/s0960-894x(98)00402-8
Streptococcus pyogenes Streptococcus pyogenes MIC 0.6 ug.mL-1 10.1016/s0960-894x(99)00534-x
Streptococcus pyogenes Streptococcus pyogenes MIC 0.6 ug.mL-1 10.1021/jm980240d
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1021/jm100711p
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1021/ml100253p
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1021/ml500279k
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pyogenes Streptococcus pyogenes MIC 2.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Streptococcus pyogenes Streptococcus pyogenes MIC 4.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.ejmech.2009.02.001
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.ejmech.2010.11.035
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.ejmech.2012.11.028
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1021/jm100711p
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1021/ml100253p
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1039/d2md00143h
Streptococcus pyogenes Streptococcus pyogenes MIC 8.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC 16.0 ug.mL-1 10.1128/aac.01383-07
Streptococcus pyogenes Streptococcus pyogenes MIC 30.0 ug.mL-1 10.1016/s0960-894x(98)00070-5
Streptococcus pyogenes Streptococcus pyogenes MIC 30.0 ug.mL-1 10.1016/s0960-894x(98)00227-3
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.048
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.049
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.06.050
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.07.007
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2010.10.024
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.010
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2011.07.011
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmc.2012.10.036
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmcl.2005.01.027
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.04.062
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.bmcl.2010.11.079
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.ejmech.2011.05.002
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1016/j.ejmech.2016.09.022
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1021/jm100711p
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1021/ml100253p
Streptococcus pyogenes Streptococcus pyogenes MIC 64.0 ug.mL-1 10.1021/ml500279k
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2012.06.092
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.06.044
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2017.07.017
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.bmcl.2018.06.006
Streptococcus pyogenes Streptococcus pyogenes MIC 128.0 ug.mL-1 10.1016/j.ejmech.2019.03.037
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2012.12.070
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2018.09.012
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2019.126850
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.bmcl.2021.128110
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.01.023
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2012.10.054
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2016.10.065
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes MIC 256.0 ug.mL-1 10.1016/j.ejmech.2019.07.022
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.015 ug.mL-1 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.06 ug.mL-1 10.1128/aac.00418-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.12 ug.mL-1 10.1128/aac.01315-06
Streptococcus pyogenes Streptococcus pyogenes MIC50 0.125 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 8.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC50 8.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 16.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC50 16.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC50 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC80 32.0 ug.mL-1 10.1016/j.bmcl.2013.07.042
Streptococcus pyogenes Streptococcus pyogenes MIC90 0.25 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 1.0 ug.mL-1 10.1128/aac.00567-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 2.0 ug.mL-1 10.1128/aac.01548-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes MIC90 8.0 ug.mL-1 10.1128/aac.01315-06
Streptococcus pyogenes Streptococcus pyogenes MIC90 16.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC90 32.0 ug.mL-1 10.1128/aac.01065-08
Streptococcus pyogenes Streptococcus pyogenes MIC90 64.0 ug.mL-1 10.1128/aac.01123-09
Streptococcus pyogenes Streptococcus pyogenes Selectivity ratio 1.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes Streptococcus pyogenes Selectivity ratio 8.0 None 10.1016/j.ejmech.2019.02.073
Streptococcus pyogenes serotype M1 Streptokinase A EC50 60.0 nM None
Streptococcus salivarius Streptococcus salivarius Activity nan None 10.1128/aac.00418-09
Streptococcus salivarius Streptococcus salivarius MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus salivarius Streptococcus salivarius MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus salivarius Streptococcus salivarius MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus sanguinis Streptococcus sanguinis Activity nan None 10.1128/aac.00418-09
Streptococcus sanguinis Streptococcus sanguinis MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus sanguinis Streptococcus sanguinis MIC50 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus sanguinis Streptococcus sanguinis MIC90 1.0 ug.mL-1 10.1128/aac.00418-09
Streptococcus sp. Streptococcus sp. Activity 98.0 % 10.1128/aac.00418-09
Streptococcus sp. Streptococcus sp. Activity nan None 10.1021/jm960294s
Streptococcus sp. Streptococcus sp. MIC 0.12 ug.mL-1 10.1128/aac.00418-09
Streptococcus sp. Streptococcus sp. MIC50 0.5 ug.mL-1 10.1128/aac.00418-09
Streptococcus sp. Streptococcus sp. MIC50 10.0 ug.mL-1 10.1021/jm980240d
Streptococcus sp. Streptococcus sp. MIC50 40.0 ug.mL-1 10.1021/jm980240d
Streptococcus sp. Streptococcus sp. MIC50/MIC90 nan None 10.1016/s0960-894x(99)00534-x
Streptococcus sp. Streptococcus sp. MIC90 0.5 ug.mL-1 10.1128/aac.00418-09
Streptococcus sp. Streptococcus sp. MIC90 40.0 ug.mL-1 10.1021/jm980240d
Streptococcus sp. 'group A' Streptococcus sp. 'group A' EC50 60.0 nM None
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 0.06 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 4.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 0.12 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 64.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 0.25 ug.mL-1 10.1128/aac.01620-07
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 64.0 ug.mL-1 10.1128/aac.01620-07
Streptococcus viridans Streptococcus viridans MIC50 1.0 ug.mL-1 10.1128/aac.01315-06
Streptococcus viridans Streptococcus viridans MIC90 4.0 ug.mL-1 10.1128/aac.01315-06
Toxoplasma gondii Toxoplasma gondii Activity nan None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii IC50 600.0 nM 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii IC50 20000.0 nM 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii IC50 29000.0 nM 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii IC50 44000.0 nM 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 3.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 4.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 7.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 8.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 10.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 13.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 15.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii Ratio 18.0 None 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii TIME 9.5 hr 10.1021/jm101593u
Toxoplasma gondii Toxoplasma gondii TIME 16.0 hr 10.1021/jm101593u
Zaire ebolavirus Zaire ebolavirus EC50 5100.0 nM 10.1016/j.ejmech.2020.112739
Zika virus Zika virus EC50 6590.0 nM 10.1016/j.ejmech.2020.112739
None ADMET Activity 20.0 % 10.1128/aac.00729-05
None ADMET Activity 40.0 % 10.1128/aac.00729-05
None ADMET AUC Ratio 0.899 None 10.1038/s41586-020-2286-9
None ADMET CL 10.0 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Cmax 4272.36 nM 10.1021/jm300356u
None ADMET Cmax 467289.72 nM 10.1021/acs.jmedchem.9b01159
None ADMET DNAUC 11.42 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 17.52 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 33.15 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 140.4 kg.min/L 10.1080/00498250400028197
None ADMET Drug uptake 0.09 ug ml-1 10.1128/aac.00022-09
None ADMET Drug uptake 2.0 ug ml-1 10.1128/aac.00962-07
None ADMET Drug uptake 30.8 ug ml-1 10.1128/aac.00022-09
None ADMET Drug uptake 38.0 % 10.1021/jm101317f
None ADMET Drug uptake 54.0 % 10.1021/jm101317f
None ADMET Drug uptake 63.0 % 10.1021/jm101317f
None ADMET Drug uptake 79.0 % 10.1021/jm101317f
None ADMET Drug uptake 80.0 % 10.1021/jm101317f
None ADMET Drug uptake 93.0 % 10.1021/jm101317f
None ADMET Drug uptake 100.0 % 10.1016/j.ejmech.2017.03.056
None ADMET Drug uptake 100.0 % 10.1021/jm101317f
None ADMET Fu 0.88 None 10.1021/jm030408h
None ADMET IC50 250000.0 nM 10.1016/j.bmc.2015.04.078
None ADMET log10(%HIA +10) 1.663 None 10.1016/j.ejmech.2010.11.005
None ADMET Log K 0.38 None 10.1021/jm960436i
None ADMET logP(lung) 2.08 None 10.1016/j.ejmech.2007.04.002
None ADMET MRT 57.0 hr 10.1124/dmd.108.020479
None ADMET Papp 1.0 10'-6 cm/s 10.1021/acs.jmedchem.8b01259
None ADMET pCF 1.36 None 10.1021/jm960436i
None ADMET pNF 3.41 None 10.1021/jm960436i
None ADMET Ratio CC50/EC50 8.8 None 10.1016/j.ejmech.2020.112739
None ADMET Ratio CC50/EC50 25.0 None 10.1016/j.ejmech.2020.112739
None ADMET Ratio CC50/EC50 123.0 None 10.1016/j.ejmech.2020.112739
None ADMET Ratio CC50/EC50 218.0 None 10.1016/j.ejmech.2020.112739
None ADMET Ratio IC50 132.0 None 10.1021/jm201676t
None ADMET Selectivity index 19.0 None 10.1101/2020.04.03.023846
None ADMET T1/2 48.0 hr 10.1021/acs.jmedchem.9b01159
None ADMET T1/2 68.0 hr 10.1016/j.bmcl.2018.11.038
None ADMET T1/2 69.0 hr 10.1124/dmd.108.020479
None ADMET T1/2 74.0 hr 10.1021/acs.jmedchem.5b01485
None ADMET Vdss 33.0 L.kg-1 10.1021/jm030408h
None ADMET Vdss 33.0 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Alkaline Phosphatase Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Index Value 1.0 None 10.2174/1570163043334794
None Hepatotoxicity Alkaline Phosphatase Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Active 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Marginal 0.0 None 10.2174/1570163043334794
None Hepatotoxicity Composite Activity - Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Index Value 1.0 None 10.2174/1570163043334794
None Hepatotoxicity GGT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 5.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity LDH Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Index Value 0.8 None 10.2174/1570163043334794
None Hepatotoxicity LDH Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Index Value 2.9 None 10.2174/1570163043334794
None Hepatotoxicity SGOT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Activity Score nan None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Index Value 2.3 None 10.2174/1570163043334794
None Hepatotoxicity SGPT Increase - Number of Reports 4.0 None 10.2174/1570163043334794
None Molecular identity unknown Activity 95.0 % 10.1128/aac.01142-06
None Molecular identity unknown Inhibition 40.8 % 10.1016/j.ejmech.2022.114629
None Molecular identity unknown Inhibition 41.5 % 10.1016/j.ejmech.2022.114629
None Molecular identity unknown Inhibition 52.5 % 10.1016/j.ejmech.2022.114629
None Molecular identity unknown Inhibition 55.2 % 10.1016/j.ejmech.2022.114629
None Molecular identity unknown Inhibition 65.0 % 10.1016/j.ejmech.2022.114629
None NON-PROTEIN TARGET Activity 0.0 % 10.1128/aac.01845-09
None NON-PROTEIN TARGET Activity 0.5 % 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 4.0 ug ml-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 11.1 % 10.1128/aac.01845-09
None NON-PROTEIN TARGET Activity 56.5 % 10.1128/aac.01845-09
None NON-PROTEIN TARGET Activity 60.0 % 10.1128/aac.01845-09
None NON-PROTEIN TARGET Activity 89.5 % 10.1128/aac.00898-09
None NON-PROTEIN TARGET Activity 98.0 % 10.1128/aac.00418-09
None NON-PROTEIN TARGET Activity nan None 10.1021/jm960294s
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00418-09
None NON-PROTEIN TARGET Fu 0.88 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 40.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 53.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC20 20.0 ug ml-1 10.1128/aac.00729-05
None NON-PROTEIN TARGET IC50 25.0 ug.mL-1 10.1128/aac.00729-05
None NON-PROTEIN TARGET Inhibition 61.0 % 10.1021/jm300356u
None NON-PROTEIN TARGET Inhibition 74.0 % 10.1021/jm300356u
None NON-PROTEIN TARGET Inhibition 84.0 % 10.1021/jm300356u
None NON-PROTEIN TARGET MIC 2e-07 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 1e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 2e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC 3.2e-05 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC 0.001 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC 0.008 ug.mL-1 10.1128/aac.00418-09
None NON-PROTEIN TARGET MIC 0.016 ug.mL-1 10.1128/aac.00044-08
None NON-PROTEIN TARGET MIC 0.03 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.06 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.063 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC 0.12 ug.mL-1 10.1128/aac.00418-09
None NON-PROTEIN TARGET MIC 0.12 ug.mL-1 10.1128/aac.00481-08
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.125 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC 0.25 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 2.0 ug.mL-1 10.1128/aac.01349-08
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.01678-09
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.01678-09
None NON-PROTEIN TARGET MIC 64.0 ug.mL-1 10.1128/aac.01678-09
None NON-PROTEIN TARGET MIC 128.0 ug.mL-1 10.1128/aac.00695-08
None NON-PROTEIN TARGET MIC 128.0 ug.mL-1 10.1128/aac.01678-09
None NON-PROTEIN TARGET MIC nan None 10.1128/aac.00046-09
None NON-PROTEIN TARGET MIC50 1e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 4e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC50 0.06 ug.mL-1 10.1128/aac.00418-09
None NON-PROTEIN TARGET MIC50 0.19 ug.mL-1 10.1128/aac.00056-07
None NON-PROTEIN TARGET MIC50 0.25 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.00418-09
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC50 2.0 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC50 2.0 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC50 8.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC50 128.0 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC50 nan None 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 2e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 8e-06 ug.mL-1 10.1128/aac.00724-09
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.00418-09
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC90 0.75 ug.mL-1 10.1128/aac.00056-07
None NON-PROTEIN TARGET MIC90 2.0 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 4.0 ug.mL-1 10.1128/aac.00090-09
None NON-PROTEIN TARGET MIC90 4.0 ug.mL-1 10.1128/aac.00849-08
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.00418-09
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.00858-06
None NON-PROTEIN TARGET MIC90 128.0 ug.mL-1 10.1128/aac.00898-09
None NON-PROTEIN TARGET MIC90 nan None 10.1128/aac.00849-08
None NON-PROTEIN TARGET Ratio 1000.0 None 10.1128/aac.00613-07
None No relevant target CLogP 0.0 None 10.1021/jm960436i
None No relevant target CLogP 1.826 None 10.1016/s0960-894x(02)00434-1
None No relevant target CLogP 1.826 None 10.1021/jm960436i
None No relevant target CLogP 4.02 None 10.1021/jm960436i
None No relevant target LogD 0.61 None 10.1021/jm960436i
None No relevant target LogD 2.11 None 10.1016/j.ejmech.2017.03.056
None No relevant target pKa 8.74 None 10.1021/jm030408h
None No relevant target pKa 9.45 None 10.1021/jm030408h
None No relevant target pKa1 8.74 None 10.1021/jm960436i
None No relevant target pKa2 9.45 None 10.1021/jm960436i
None Osteoblast IC20 80.0 ug ml-1 10.1128/aac.00729-05
None Osteoblast IC50 160.0 ug.mL-1 10.1128/aac.00729-05
None Phospholipidosis Maximum test concentration that did not exhibit cytotoxicity 25.0 uM None
None Phospholipidosis Phospholipidosis nan None 10.1021/mp100103e
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Phospholipidosis Phospholipidosis as % of positive control 26.7 % None
None Unchecked Activity 25.0 % 10.1128/aac.01142-06
None Unchecked Activity 30.0 % 10.1128/aac.01142-06
None Unchecked Activity 40.0 % 10.1128/aac.01142-06
None Unchecked Activity 45.0 % 10.1128/aac.01142-06
None Unchecked Activity 50.0 % 10.1128/aac.01142-06
None Unchecked Activity 64.0 % 10.1128/aac.01142-06
None Unchecked Activity 65.0 % 10.1128/aac.01142-06
None Unchecked Activity 76.0 % 10.1021/np100472d
None Unchecked Activity 86.3 % 10.1016/j.bmcl.2020.127336
None Unchecked Activity nan None 10.1021/acsmedchemlett.8b00472
None Unchecked Hepatotoxicity (acute) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 4.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 292.0 nM 10.1016/j.bmc.2015.04.078
None Unchecked IC50 1210.0 nM None
None Unchecked IC50 1280.0 nM None
None Unchecked IC50 2334.0 nM None
None Unchecked IC50 2360.0 nM None
None Unchecked IC50 2370.0 nM None
None Unchecked IC50 3630.0 nM None
None Unchecked IC50 nan None 10.1016/j.bmc.2015.07.062
None Unchecked IC50 nan None None
None Unchecked Inhibition 76.0 % 10.1021/np100472d
None Unchecked Inhibition 90.6 % 10.1016/j.bmcl.2020.127336
None Unchecked Inhibition nan % 10.1021/acsmedchemlett.0c00632
None Unchecked Kcat 0.292 /s 10.1128/aac.01570-09
None Unchecked Kcat/Km 1.05 10'4/s/M 10.1128/aac.01570-09
None Unchecked Kd 1410.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1620.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1630.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 1900.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Kd 7430.0 nM 10.1016/j.bmc.2015.07.062
None Unchecked Ki nan None None
None Unchecked Km 27700.0 nM 10.1128/aac.01570-09
None Unchecked MIC50 2.5 ug.mL-1 10.1021/jm980240d
None Unchecked MIC50 40.0 ug.mL-1 10.1021/jm980240d
None Unchecked MIC90 40.0 ug.mL-1 10.1021/jm980240d
None Unchecked Potency 631.0 nM None
None Unchecked Potency 2818.4 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 14125.4 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 39810.7 nM None
None Unchecked Ratio 1.2 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio 4.5 None 10.1016/j.bmc.2015.07.062
None Unchecked Ratio CC50/EC50 19.0 None 10.1016/j.ejmech.2020.112739
None Unchecked Selectivity Index nan None 10.1016/j.bmcl.2019.03.038
None Unchecked Time nan None 10.1128/aac.00620-10
None Unchecked TIME 0.005556 hr 10.1128/aac.00620-10

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT010285 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OP(=O)(O)O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O.Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O None
AKRT010286 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O>>CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2OP(=O)(O)O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O enzymemap_43340