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cyclo(L-Leu-L-Pro)

AlkaPlorer ID: AK010658

Synonym: '', 'cyclo (L)-Pro-(L)-Leu', 'cyclo-(Pro-Leu)', 'cyclo(Leu-Pro)', 'Cyclo(leucylprolyl)', 'Cyclo(D)-Pro-(D)-Leu', 'Gancidin W', '32510-93-3', 'Cyclo(pro-leu)', 'Cyclo-L-leu-L-pro', 'cyclo(L-prolyl-L-leucyl)', 'cycloL-Leucyl-L-Prolyl', 'L-cyclo(Leu-pro)', '43041-29-8', 'cyclo(L-leucyl-L-prolyl)', 'cycloL-leucyl-L-prolyl', 'Maculosin 6', '19943-30-7', 'cyclo(Pro-Leu)', '36238-67-2', 'L,L-Cyclo(leucylprolyl)', 'L-Leucyl-L-proline lactam', '2873-36-1', 'L-cyclo(Leucyloprolyl)', 'cyclo(L-Pro-L-Leu)'

IUPAC Name: (3R,8aS)-3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Structure

SMILES: CC(C)C[C@H]1NC(=O)[C@@H]2CCCN2C1=O

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InChI: InChI=1S/C11H18N2O2/c1-7(2)6-8-11(15)13-5-3-4-9(13)10(14)12-8/h7-9H,3-6H2,1-2H3,(H,12,14)/t8-,9+/m1/s1

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InChIKey: SZJNCZMRZAUNQT-BDAKNGLRSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 210.277

TPSA？: 49.41

MolLogP？: 0.5218999999999998

Number of H-Donors: 1

Number of H-Acceptors: 2

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis MIC nan None 10.1021/acs.jnatprod.1c00975
Candida albicans Candida albicans MIC nan None 10.1021/acs.jnatprod.1c00975
Chromobacterium violaceum Chromobacterium violaceum MIC nan None 10.1021/acs.jnatprod.1c00975
Escherichia coli Escherichia coli MIC nan None 10.1021/acs.jnatprod.1c00975
Homo sapiens HUVEC Activity nan None 10.1016/j.bmcl.2016.03.030
Homo sapiens HUVEC Inhibition nan % 10.1016/j.bmcl.2016.03.030
Homo sapiens KB 3-1 IC50 nan None 10.1021/acs.jnatprod.1c00975
Homo sapiens NCI-H460 IC50 50000.0 nM 10.1016/j.bmcl.2017.03.095
Micrococcus luteus Micrococcus luteus MIC nan None 10.1021/acs.jnatprod.1c00975
Mucor hiemalis Mucor hiemalis MIC nan None 10.1021/acs.jnatprod.1c00975
Mus musculus L929 IC50 nan None 10.1021/acs.jnatprod.1c00975
Mus musculus Mus musculus Activity 40.0 % 10.1016/j.bmcl.2016.03.030
Mus musculus Mus musculus Activity nan None 10.1016/j.bmcl.2016.03.030
Mus musculus Mus musculus Inhibition nan % 10.1016/j.bmcl.2016.03.030
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC nan None 10.1021/acs.jnatprod.1c00975
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1021/acs.jnatprod.1c00975
Rhodotorula glutinis Rhodotorula glutinis MIC nan None 10.1021/acs.jnatprod.1c00975
Schizosaccharomyces pombe Schizosaccharomyces pombe MIC nan None 10.1021/acs.jnatprod.1c00975
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/acs.jnatprod.1c00975
Vibrio anguillarum Vibrio anguillarum MIC 0.12 ug.mL-1 10.1021/np030233e
Wickerhamomyces anomalus Wickerhamomyces anomalus MIC nan None 10.1021/acs.jnatprod.1c00975

Metabolism Information