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manzamine A

AlkaPlorer ID: AK011091

Synonym: '', 'Manzamine A', '104196-68-1'

IUPAC Name: (1R,2R,4R,5Z,12R,13S,16Z)-25-(9H-pyrido[3,4-b]indol-1-yl)-11,22-diazapentacyclo[11.11.2.12,22.02,12.04,11]heptacosa-5,16,25-trien-13-ol

Structure

SMILES: O[C@]12C=C(C3=NC=CC4=C3NC3=CC=CC=C34)[C@@H]3CCN(CCCC/C=C\CC1)C[C@@]31C[C@@H]3/C=C\CCCCN3[C@H]12

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InChI: InChI=1S/C36H44N4O/c41-36-18-10-4-1-2-5-11-20-39-22-17-30(35(25-39)23-26-13-7-3-6-12-21-40(26)34(35)36)29(24-36)32-33-28(16-19-37-32)27-14-8-9-15-31(27)38-33/h1,4,7-9,13-16,19,24,26,30,34,38,41H,2-3,5-6,10-12,17-18,20-23,25H2/b4-1-,13-7-/t26-,30-,34+,35-,36-/m0/s1

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InChIKey: FUCSLKWLLSEMDQ-MKYGIPPKSA-N

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Reference

Manzamine A, a novel antitumor alkaloid from a sponge

PubChem CID: 6509753

LOTUS: LTS0202401

NPASS: NPC166492

data_source: manually

Properties Information

Molecule Weight: 548.7750000000004

TPSA？: 55.39000000000001

MolLogP？: 6.855800000000007

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 8

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus fumigatus Aspergillus fumigatus Activity nan None 10.1016/j.bmc.2008.05.079
Bacillus spizizenii Bacillus spizizenii MIC 0.05 ug.mL-1 10.1021/acs.jnatprod.7b00121
Bacillus subtilis Bacillus subtilis IZ 7.0 mm 10.1021/np9604083
Bos taurus Acetylcholinesterase Activity nan None 10.1021/np0601399
Candida albicans Candida albicans Activity nan None 10.1016/j.bmc.2008.05.079
Candida albicans Candida albicans IC50 2.0 ug.mL-1 10.1021/jm900672t
Candida albicans Candida albicans IC50 2.0 ug.mL-1 10.1021/np800163u
Candida albicans Candida albicans IC50 3656.0 nM 10.1016/j.bmc.2009.09.026
Candida albicans Candida albicans IC50 16400.0 nM 10.1016/j.bmc.2008.05.079
Candida albicans Candida albicans MFC nan None 10.1021/np800163u
Candida albicans Candida albicans MIC nan None 10.1016/j.bmc.2009.09.026
Candida albicans Candida albicans MIC nan None 10.1021/np800163u
Canis lupus familiaris MDCK Papp 0.87 10'-6 cm/s 10.1021/jm900672t
Canis lupus familiaris MDCK Ratio 1.0 None 10.1021/jm900672t
Chlorocebus sabaeus Vero Activity 1.2 ug ml-1 10.1021/np0400095
Chlorocebus sabaeus Vero Activity 1200.0 ng/ml 10.1021/np020592u
Chlorocebus sabaeus Vero IC50 0.2 ug.mL-1 10.1021/jm900672t
Chlorocebus sabaeus Vero IC50 1.2 ug.mL-1 10.1021/np0601399
Chlorocebus sabaeus Vero IC50 501.0 nM 10.1016/j.bmc.2008.05.079
Chlorocebus sabaeus Vero TC50 365.0 nM 10.1016/j.bmc.2009.09.026
Chlorocebus sabaeus Vero TC50 680.0 ug ml-1 10.1021/np800163u
Corynebacterium xerosis Corynebacterium xerosis MIC 5.7 ug.mL-1 10.1021/np970564p
Cricetulus griseus CHO Inhibition nan % 10.1016/j.bmc.2013.04.025
Cryptococcus neoformans Cryptococcus neoformans IC50 1.0 ug.mL-1 10.1021/jm900672t
Cryptococcus neoformans Cryptococcus neoformans IC50 3.0 ug.mL-1 10.1021/np0400095
Cryptococcus neoformans Cryptococcus neoformans IC50 3.0 ug.mL-1 10.1021/np0601399
Cryptococcus neoformans Cryptococcus neoformans IC50 3.0 ug.mL-1 10.1021/np800163u
Cryptococcus neoformans Cryptococcus neoformans IC50 1848.0 nM 10.1016/j.bmc.2009.09.026
Cryptococcus neoformans Cryptococcus neoformans IC50 2700.0 nM 10.1016/j.bmc.2008.05.079
Cryptococcus neoformans Cryptococcus neoformans MFC 23.0 uM 10.1016/j.bmc.2008.05.079
Cryptococcus neoformans Cryptococcus neoformans MFC nan None 10.1021/np800163u
Cryptococcus neoformans Cryptococcus neoformans MIC 10.0 ug.mL-1 10.1021/np800163u
Cryptococcus neoformans Cryptococcus neoformans MIC 5700.0 nM 10.1016/j.bmc.2008.05.079
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmc.2008.05.079
Escherichia coli Escherichia coli IZ 7.0 mm 10.1021/np9604083
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.7b00121
Homo sapiens A549 IC50 1.3 ug.mL-1 10.1021/np50096a015
Homo sapiens A549 IC50 5800.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens A549 LC50 8300.0 nM 10.1021/acs.jnatprod.7b00121
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase 1 IC50 6200.0 nM 10.1016/j.bmc.2013.04.025
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase 1 IC50 6400.0 nM 10.1016/j.bmc.2013.04.025
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase 1 Inhibition nan % 10.1016/j.bmc.2013.04.025
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase 2 IC50 4800.0 nM 10.1016/j.bmc.2013.04.025
Homo sapiens Acyl coenzyme A:cholesterol acyltransferase 2 Inhibition nan % 10.1016/j.bmc.2013.04.025
Homo sapiens Beta-secretase 1 Activity nan None 10.1021/np0601399
Homo sapiens C-33-A Activity 1.8 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 6.3 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 9.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 11.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 15.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 17.4 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 18.3 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 19.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 19.3 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 24.6 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 31.3 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 34.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 36.5 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 44.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 58.5 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 63.6 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity 72.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Activity nan None 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A IC50 1600.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A IC50 2100.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A IC50 5200.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens C-33-A Inhibition nan % 10.1021/acs.jnatprod.9b00577
Homo sapiens Casein kinase II alpha Inhibition nan % 10.1021/acs.jnatprod.9b00577
Homo sapiens Casein kinase II alpha Ratio 10.0 None 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 7.8 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 10.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 10.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 13.4 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 15.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 16.9 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 23.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 76.9 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 77.6 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 81.4 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 81.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity 82.4 % 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Activity nan None 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski FC 1.4 None 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski FC 1.5 None 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski IC50 9400.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski IC50 19900.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski IC50 33600.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens Ca-Ski Inhibition nan % 10.1021/acs.jnatprod.9b00577
Homo sapiens Cyclin-dependent kinase 1 Activity nan None 10.1021/np060092r
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 1500.0 nM 10.1021/np060092r
Homo sapiens Glycogen synthase kinase-3 alpha Activity nan None 10.1021/np060092r
Homo sapiens Glycogen synthase kinase-3 alpha IC50 25000.0 nM 10.1021/np800163u
Homo sapiens Glycogen synthase kinase-3 beta Activity nan None 10.1021/np0601399
Homo sapiens Glycogen synthase kinase-3 beta IC50 10000.0 nM 10.1021/np800163u
Homo sapiens Glycogen synthase kinase-3 beta IC50 10200.0 nM 10.1016/j.bmc.2008.05.079
Homo sapiens Glycogen synthase kinase-3 beta IC50 10200.0 nM 10.1016/j.bmcl.2012.09.043
Homo sapiens Glycogen synthase kinase-3 beta IC50 10200.0 nM 10.1021/np060092r
Homo sapiens Glycogen synthase kinase-3 beta IC50 12300.0 nM 10.1016/j.bmc.2009.06.054
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 73.2 % 10.1021/np060092r
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 73.2 % 10.1021/np0601399
Homo sapiens HeLa Activity 2.0 ug ml-1 10.1021/jm900672t
Homo sapiens HeLa Activity 2.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 5.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 10.5 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 11.8 % 10.1021/jm900672t
Homo sapiens HeLa Activity 13.0 % 10.1021/jm900672t
Homo sapiens HeLa Activity 13.6 % 10.1021/jm900672t
Homo sapiens HeLa Activity 13.8 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 14.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 14.3 % 10.1021/jm900672t
Homo sapiens HeLa Activity 16.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 20.8 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 24.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 24.3 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 49.1 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 56.2 % 10.1021/jm900672t
Homo sapiens HeLa Activity 56.3 % 10.1021/jm900672t
Homo sapiens HeLa Activity 59.0 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 59.1 % 10.1021/jm900672t
Homo sapiens HeLa Activity 63.9 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 67.2 % 10.1021/jm900672t
Homo sapiens HeLa Activity 74.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 75.9 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity 81.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa Activity nan None 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa IC50 4000.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa IC50 5300.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa IC50 11800.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens HeLa IC50 13000.0 nM 10.1021/np500290a
Homo sapiens HeLa Inhibition nan % 10.1021/acs.jnatprod.9b00577
Homo sapiens Homeobox protein SIX1 Inhibition nan % 10.1021/acs.jnatprod.9b00577
Homo sapiens Homeobox protein SIX1 Ratio 10.0 None 10.1021/acs.jnatprod.9b00577
Homo sapiens HT-29 IC50 0.8 ug.mL-1 10.1021/np50096a015
Homo sapiens K562 IC50 5200.0 nM 10.1016/j.ejmech.2021.113839
Homo sapiens K562 LC50 11000.0 nM 10.1021/acs.jnatprod.7b00121
Homo sapiens KB IC50 0.05 ug.mL-1 10.1021/np50103a027
Homo sapiens Keratinocyte Activity nan None 10.1021/acs.jnatprod.9b00577
Homo sapiens LoVo IC50 0.15 ug.mL-1 10.1021/np50103a027
Homo sapiens MCF7 Activity 63.0 % 10.1007/s00044-004-0054-2
Homo sapiens MCF7 Activity 80.0 % 10.1007/s00044-004-0054-2
Homo sapiens MCF7 Activity 89.0 % 10.1007/s00044-004-0054-2
Homo sapiens MCF7 FC 2.0 None 10.1007/s00044-004-0054-2
Homo sapiens MCF7 %PFU 9.0 % 10.1007/s00044-004-0054-2
Homo sapiens MCF7 %PFU 15.0 % 10.1007/s00044-004-0054-2
Homo sapiens MCF7 %PFU 46.0 % 10.1007/s00044-004-0054-2
Homo sapiens NCI-H1299 Activity nan None 10.1016/j.bmcl.2016.09.030
Homo sapiens SH-SY5Y Activity nan None 10.1021/np0601399
Homo sapiens SiHa Activity 4.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 8.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 9.2 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 12.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 13.7 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 27.0 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 33.6 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 66.4 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 78.6 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 82.5 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 85.3 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity 86.4 % 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Activity nan None 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa FC 1.2 None 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa IC50 4100.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa IC50 9900.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa IC50 19900.0 nM 10.1021/acs.jnatprod.9b00577
Homo sapiens SiHa Inhibition nan % 10.1021/acs.jnatprod.9b00577
Homo sapiens Sodium/potassium-transporting ATPase IC50 150000.0 nM 10.1021/acs.jnatprod.7b00121
Homo sapiens Voltage-gated calcium channel Inhibition 20.0 % 10.1021/np0601399
Human alphaherpesvirus 1 Human alphaherpesvirus 1 Inhibition nan % 10.1016/j.bmcl.2012.06.031
Human alphaherpesvirus 2 Human alphaherpesvirus 2 MIC 0.05 ug.mL-1 10.1021/np50103a027
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 590.0 nM 10.1021/np020592u
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 4200.0 nM 10.1021/np0400095
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 4.2 ug.mL-1 10.1021/np0601399
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 4200.0 nM 10.1016/j.ejmech.2018.08.027
Human papillomavirus type 16 Protein E6 Inhibition nan % 10.1021/acs.jnatprod.9b00577
Human papillomavirus type 16 Protein E7 Inhibition nan % 10.1021/acs.jnatprod.9b00577
Human papillomavirus type 18 Protein E6 Inhibition nan % 10.1021/acs.jnatprod.9b00577
Kocuria rhizophila Kocuria rhizophila MIC 0.05 ug.mL-1 10.1021/acs.jnatprod.7b00121
Leishmania donovani Leishmania donovani IC50 0.9 ug.mL-1 10.1021/np020592u
Leishmania donovani Leishmania donovani IC50 0.9 ug.mL-1 10.1021/np0400095
Leishmania donovani Leishmania donovani IC50 0.9 ug.mL-1 10.1021/np0601399
Leishmania donovani Leishmania donovani IC50 0.9 ug.mL-1 10.1021/np800163u
Leishmania donovani Leishmania donovani IC90 1.8 ug.mL-1 10.1021/np020592u
Leishmania donovani Leishmania donovani IC90 1.8 ug.mL-1 10.1021/np0400095
Leishmania donovani Leishmania donovani IC90 1.8 ug.mL-1 10.1021/np0601399
Leishmania donovani Leishmania donovani IC90 1.8 ug.mL-1 10.1021/np800163u
Micrococcus luteus Micrococcus luteus MIC 2.3 ug.mL-1 10.1021/np970564p
Mus musculus L1210 IC50 1.4 ug.mL-1 10.1021/np970564p
Mus musculus L5178Y ED50 1.8 ug ml-1 10.1021/np9604083
Mus musculus Mus musculus Activity 20.0 % 10.1016/j.bmc.2013.04.025
Mus musculus Mus musculus Activity 40.0 % 10.1016/j.bmc.2013.04.025
Mus musculus Mus musculus Activity 45.0 % 10.1016/j.bmc.2013.04.025
Mus musculus Mus musculus Activity 50.0 % 10.1016/j.bmc.2013.04.025
Mus musculus Mus musculus Activity nan None 10.1021/jm900672t
Mus musculus P388 IC50 0.07 ug.mL-1 10.1016/j.bmc.2021.116560
Mus musculus P388 IC50 0.07 ug.mL-1 10.1021/np50103a027
Mus musculus P388 IC50 2.4 ug.mL-1 10.1021/np50096a015
Mycobacterium intracellulare Mycobacterium intracellulare IC50 0.35 ug.mL-1 10.1021/jm900672t
Mycobacterium intracellulare Mycobacterium intracellulare IC50 0.35 ug.mL-1 10.1021/np0400095
Mycobacterium intracellulare Mycobacterium intracellulare IC50 0.35 ug.mL-1 10.1021/np0601399
Mycobacterium intracellulare Mycobacterium intracellulare IC50 0.35 ug.mL-1 10.1021/np800163u
Mycobacterium intracellulare Mycobacterium intracellulare IC50 180.0 nM 10.1016/j.bmc.2008.05.079
Mycobacterium intracellulare Mycobacterium intracellulare IC50 640.0 nM 10.1016/j.bmc.2009.09.026
Mycobacterium intracellulare Mycobacterium intracellulare MBC 2.84 uM 10.1016/j.bmc.2008.05.079
Mycobacterium intracellulare Mycobacterium intracellulare MBC nan None 10.1021/np800163u
Mycobacterium intracellulare Mycobacterium intracellulare MIC 0.63 ug.mL-1 10.1021/np800163u
Mycobacterium intracellulare Mycobacterium intracellulare MIC 360.0 nM 10.1016/j.bmc.2008.05.079
Mycobacterium tuberculosis Mycobacterium tuberculosis Activity 95.0 % 10.1021/np0703702
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.5 ug.mL-1 10.1021/np0400095
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.5 ug.mL-1 10.1021/np0601399
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.53 ug.mL-1 10.1021/jm900672t
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.53 ug.mL-1 10.1021/np020592u
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1.56 ug.mL-1 10.1021/jm900672t
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 12.5 ug.mL-1 10.1021/np0703702
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 1640.0 nM 10.1016/j.ejmech.2019.01.026
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC50 1.5 ug.mL-1 10.1016/j.bmc.2021.116560
Oryzias latipes Oryzias latipes LD50 0.074 uM 10.1021/np0601399
Plasmodium berghei Plasmodium berghei Activity 14.3 day 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Activity 19.7 day 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Activity 24.3 day 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Activity 90.0 % 10.1016/j.bmc.2021.116560
Plasmodium berghei Plasmodium berghei Activity 90.0 % 10.1021/np800163u
Plasmodium berghei Plasmodium berghei Activity 100.0 % 10.1021/np800163u
Plasmodium berghei Plasmodium berghei Inhibition 0.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 0.2 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 0.4 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 0.9 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 1.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 1.9 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 2.8 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 3.3 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 4.3 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 4.5 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 5.2 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 5.5 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 6.25 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 7.8 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 11.5 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 11.9 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 13.5 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 21.6 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 21.7 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 25.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 26.5 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 30.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 39.3 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 39.6 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 50.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 53.9 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 58.6 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 60.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 75.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 88.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 98.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition 100.0 % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei Inhibition nan % 10.1021/jm900672t
Plasmodium berghei Plasmodium berghei MST 5.6 % 10.1021/jm900672t
Plasmodium falciparum Plasmodium falciparum IC50 0.0042 ug.mL-1 10.1021/np800163u
Plasmodium falciparum Plasmodium falciparum IC50 0.0045 ug.mL-1 10.1016/j.ejmech.2021.113536
Plasmodium falciparum Plasmodium falciparum IC50 0.0045 ug.mL-1 10.1021/jm900672t
Plasmodium falciparum Plasmodium falciparum IC50 0.0045 ug.mL-1 10.1021/np020592u
Plasmodium falciparum Plasmodium falciparum IC50 0.0045 ug.mL-1 10.1021/np0400095
Plasmodium falciparum Plasmodium falciparum IC50 0.0045 ug.mL-1 10.1021/np0601399
Plasmodium falciparum Plasmodium falciparum IC50 0.005 ug.mL-1 10.1021/np800163u
Plasmodium falciparum Plasmodium falciparum IC50 0.008 ug.mL-1 10.1016/j.ejmech.2021.113536
Plasmodium falciparum Plasmodium falciparum IC50 0.008 ug.mL-1 10.1021/jm900672t
Plasmodium falciparum Plasmodium falciparum IC50 0.008 ug.mL-1 10.1021/np020592u
Plasmodium falciparum Plasmodium falciparum IC50 0.008 ug.mL-1 10.1021/np0400095
Plasmodium falciparum Plasmodium falciparum IC50 0.008 ug.mL-1 10.1021/np0601399
Plasmodium falciparum Plasmodium falciparum IC50 8.0 nM 10.1016/j.bmc.2009.09.026
Plasmodium falciparum Plasmodium falciparum IC50 11.0 nM 10.1016/j.bmc.2009.09.026
Plasmodium falciparum Plasmodium falciparum IC50 17.0 nM 10.1016/j.bmc.2008.05.079
Plasmodium falciparum Plasmodium falciparum IC50 20.0 nM 10.1016/j.bmc.2008.05.079
Plasmodium falciparum Plasmodium falciparum MIC 4.5 ug.mL-1 10.1016/j.ejmech.2017.04.003
Plasmodium yoelii Plasmodium yoelii ED50 0.57 mg.kg-1 10.1021/jm900672t
Plasmodium yoelii Plasmodium yoelii ED90 1.7 mg kg-1 10.1021/jm900672t
Proteus hauseri Proteus hauseri MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.7b00121
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1016/j.bmc.2008.05.079
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 0.0031 ug.mL-1 10.1021/acs.jnatprod.7b00121
Spodoptera littoralis Spodoptera littoralis ED50 35.0 ppm 10.1021/np9604083
Spodoptera littoralis Spodoptera littoralis Inhibition 80.0 % 10.1021/np9604083
Staphylococcus aureus Sortase A IC50 150000.0 nM 10.1021/acs.jnatprod.7b00121
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.bmc.2008.05.079
Staphylococcus aureus Staphylococcus aureus IC50 0.5 ug.mL-1 10.1021/jm900672t
Staphylococcus aureus Staphylococcus aureus IC50 0.5 ug.mL-1 10.1021/np0400095
Staphylococcus aureus Staphylococcus aureus IC50 0.5 ug.mL-1 10.1021/np0601399
Staphylococcus aureus Staphylococcus aureus IC50 0.7 ug.mL-1 10.1021/jm900672t
Staphylococcus aureus Staphylococcus aureus IC50 0.7 ug.mL-1 10.1021/np0400095
Staphylococcus aureus Staphylococcus aureus IC50 0.7 ug.mL-1 10.1021/np0601399
Staphylococcus aureus Staphylococcus aureus IC50 0.7 ug.mL-1 10.1021/np800163u
Staphylococcus aureus Staphylococcus aureus IC50 180.0 nM 10.1016/j.bmc.2008.05.079
Staphylococcus aureus Staphylococcus aureus IZ 7.0 mm 10.1021/np9604083
Staphylococcus aureus Staphylococcus aureus MFC nan None 10.1021/np800163u
Staphylococcus aureus Staphylococcus aureus MIC 0.1 ug.mL-1 10.1021/acs.jnatprod.7b00121
Staphylococcus aureus Staphylococcus aureus MIC 6.3 ug.mL-1 10.1016/j.bmc.2021.116560
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1021/np800163u
Sus scrofa Tubulin Inhibition nan % 10.1021/jm900672t
None ADMET Activity nan None 10.1016/j.bmc.2013.04.025
None ADMET ED50 0.17 uM 10.1021/np0601399
None ADMET LD50 200.0 mg.kg-1 10.1021/acs.jnatprod.9b00577
None ADMET Ratio 2.3 None 10.1021/np0601399
None ADMET TI 25.0 None 10.1016/j.bmc.2009.09.026
None ADMET TI 44.0 None 10.1016/j.bmc.2009.09.026
None Macrophage Inhibition 80.0 % 10.1021/np500290a
None NON-PROTEIN TARGET Activity 10.0 uM 10.1021/jm900672t
None NON-PROTEIN TARGET Activity nan None 10.1021/np0703702
None NON-PROTEIN TARGET IC50 100.0 nM 10.1021/jm900672t
None NON-PROTEIN TARGET IC50 100.0 nM 10.1021/np0703702
None NON-PROTEIN TARGET IC50 1100.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 1500.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 1600.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 2100.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 2300.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 3900.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 4100.0 nM 10.1016/j.bmc.2013.04.025
None NON-PROTEIN TARGET IC50 6200.0 nM 10.1016/j.bmc.2013.04.025
None NON-PROTEIN TARGET IC50 6800.0 nM 10.1016/j.bmcl.2016.09.030
None NON-PROTEIN TARGET IC50 nan None 10.1021/np50096a015
None NON-PROTEIN TARGET Inhibition nan % 10.1016/j.bmc.2013.04.025
None Unchecked Activity nan None 10.1016/j.bmc.2013.04.025
None Unchecked Activity nan None 10.1021/np060092r
None Unchecked IC50 0.07 ug.mL-1 10.1016/j.ejmech.2021.113688
None Unchecked IC50 2000.0 nM 10.1021/np500290a
None Unchecked IC50 5800.0 nM 10.1016/j.bmc.2013.04.025
None Unchecked IC50 140000.0 nM 10.1021/acs.jnatprod.7b00121
None Unchecked Inhibition nan % 10.1016/j.bmc.2013.04.025
None Unchecked Ratio IC50 25.23 None 10.1016/j.bmc.2008.05.079
None Unchecked Ratio IC50 29.4 None 10.1016/j.bmc.2008.05.079
None Unchecked Ratio IC50 44.0 None 10.1021/jm900672t

Metabolism Information