Molecule

Neplanocin A

AlkaPlorer ID: AK011116

Synonym: None

IUPAC Name: (1S,2R,5R)-5-(6-aminopurin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

Structure

SMILES: NC1=NC=NC2=C1N=CN2[C@@H]1C=C(CO)[C@@H](O)[C@H]1O

InChI: InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1

InChIKey: XUGWUUDOWNZAGW-VDAHYXPESA-N

Reference

The isolation and absolute configuration of (1S,2S,3R)-4- Hydroxymethylcyclopent-4-ene-1,2,3-triol: A putative intermediate in the biosynthesis of aristeromycin by Streptomyces citricolor

PubChem CID: 72968

CAS: 72877-50-0

LOTUS: LTS0002698

SuperNatural Ⅲ: SN0440299-01

{

NPAtlas: NPA013055

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Actinoplanes regularis	Actinoplanes	Micromonosporaceae	Micromonosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 263.257

TPSA？: 130.31

MolLogP？: -1.3963000000000003

Number of H-Donors: 4

Number of H-Acceptors: 8

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bos taurus	Adenosine deaminase	Compound remaining	0.0	%	10.1021/jm00080a018
Bos taurus	Adenosine deaminase	Compound remaining	5.0	%	10.1021/jm00080a018
Bos taurus	Monoamine oxidase A	Activity	nan	None	10.1021/jm800656v
Canis lupus familiaris	MDCK	IC50	20.0	ug.mL-1	10.1021/jm00080a018
Canis lupus familiaris	MDCK	MIC	20.0	ug.mL-1	10.1021/jm00096a012
Canis lupus familiaris	MDCK	MIC50	0.3	ug.mL-1	10.1021/jm00006a023
Canis lupus familiaris	MDCK	MIC50	1.0	ug.mL-1	10.1021/jm00035a020
Canis lupus familiaris	MDCK	MIC50	1.2	ug.mL-1	10.1021/jm00030a014
Canis lupus familiaris	MDCK	MIC50	2.8	ug.mL-1	10.1021/jm00030a014
Canis lupus familiaris	MDCK	MIC50	3.0	ug.mL-1	10.1021/jm00035a020
Canis lupus familiaris	MDCK	MIC50	4.0	ug.mL-1	10.1021/jm00006a023
Chlorocebus sabaeus	Vero	CC50	0.5	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	CC50	2.0	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	CC50	4.0	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	CC50	10.0	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	CC50	152.0	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	EC50	0.03	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	EC50	0.14	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	EC50	0.21	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	EC50	100.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	ED50	0.24	ug ml-1	10.1016/S0960-894X(01)80163-3
Chlorocebus sabaeus	Vero	IC50	0.2	ug.mL-1	10.1021/jm00080a018
Chlorocebus sabaeus	Vero	IC50	0.21	ug.mL-1	10.1021/jm00080a018
Chlorocebus sabaeus	Vero	IC50	0.26	ug.mL-1	10.1016/S0960-894X(01)80163-3
Chlorocebus sabaeus	Vero	IC50	0.4	ug.mL-1	10.1021/jm00080a018
Chlorocebus sabaeus	Vero	IC50	0.5	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	0.7	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	0.74	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	IC50	1.0	ug.mL-1	10.1021/jm950853f
Chlorocebus sabaeus	Vero	IC50	1.5	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	2.0	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	4.3	ug.mL-1	10.1021/jm00080a018
Chlorocebus sabaeus	Vero	IC50	7.0	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	10.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	IC50	10.0	ug.mL-1	10.1021/jm00080a018
Chlorocebus sabaeus	Vero	IC50	20.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	IC50	40.0	ug.mL-1	10.1021/jm00080a018
Chlorocebus sabaeus	Vero	IC50	40.0	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	50.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	IC50	57.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	IC50	100.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
Chlorocebus sabaeus	Vero	IC50	152.0	ug.mL-1	10.1016/S0960-894X(01)80163-3
Chlorocebus sabaeus	Vero	IC50	155.0	ug.mL-1	10.1021/jm960145+
Chlorocebus sabaeus	Vero	IC50	3500.0	nM	10.1021/jm010256v
Chlorocebus sabaeus	Vero	IC50	580000.0	nM	10.1021/jm010374i
Chlorocebus sabaeus	Vero	MIC	0.2	ug.mL-1	10.1021/jm00096a012
Chlorocebus sabaeus	Vero	MIC	0.4	ug.mL-1	10.1021/jm00096a012
Chlorocebus sabaeus	Vero	MIC	40.0	ug.mL-1	10.1021/jm00096a012
Chlorocebus sabaeus	Vero	MIC50	0.2	ug.mL-1	10.1021/jm00006a023
Chlorocebus sabaeus	Vero	MIC50	0.2	ug.mL-1	10.1021/jm00035a020
Chlorocebus sabaeus	Vero	MIC50	0.4	ug.mL-1	10.1021/jm00030a014
Chlorocebus sabaeus	Vero	MIC50	0.7	ug.mL-1	10.1021/jm00006a023
Chlorocebus sabaeus	Vero	MIC50	0.7	ug.mL-1	10.1021/jm00030a014
Chlorocebus sabaeus	Vero	MIC50	0.7	ug.mL-1	10.1021/jm00035a020
Chlorocebus sabaeus	Vero	MIC50	1.0	ug.mL-1	10.1021/jm00006a023
Chlorocebus sabaeus	Vero	MIC50	1.0	ug.mL-1	10.1021/jm00035a020
Chlorocebus sabaeus	Vero	MIC50	2.0	ug.mL-1	10.1021/jm00006a023
Chlorocebus sabaeus	Vero	MIC50	2.0	ug.mL-1	10.1021/jm00035a020
Chlorocebus sabaeus	Vero	MIC50	7.0	ug.mL-1	10.1021/jm00006a023
Chlorocebus sabaeus	Vero	MIC50	7.0	ug.mL-1	10.1021/jm00035a020
Chlorocebus sabaeus	Vero	MIC50	10.0	ug.mL-1	10.1021/jm00030a014
Chlorocebus sabaeus	Vero	MIC50	40.0	ug.mL-1	10.1021/jm00006a023
Cowpox virus	Cowpox virus	EC50	8400.0	nM	10.1016/j.bmc.2006.10.043
Cowpox virus	Cowpox virus	IC50	300000.0	nM	10.1016/j.bmc.2006.10.043
Homo sapiens	A549	IC50	1220.0	nM	10.1021/acs.jmedchem.5b00553
Homo sapiens	A549	IC50	2160.0	nM	10.1016/j.ejmech.2018.06.003
Homo sapiens	Adenosylhomocysteinase	Activity	0.0	%	10.1021/jm00398a002
Homo sapiens	Adenosylhomocysteinase	Activity	nan	None	10.1021/jm1010836
Homo sapiens	Adenosylhomocysteinase	Activity remaining	0.0	%	10.1021/jm025557z
Homo sapiens	Adenosylhomocysteinase	Activity remaining	97.0	%	10.1021/jm025557z
Homo sapiens	Adenosylhomocysteinase	Activity remaining	98.0	%	10.1021/jm025557z
Homo sapiens	Adenosylhomocysteinase	Activity remaining	99.0	%	10.1021/jm025557z
Homo sapiens	Adenosylhomocysteinase	Activity remaining	100.0	%	10.1021/jm025557z
Homo sapiens	Adenosylhomocysteinase	IC50	0.004	ug.mL-1	10.1021/jm00080a018
Homo sapiens	Adenosylhomocysteinase	IC50	0.004	ug.mL-1	10.1021/jm950853f
Homo sapiens	Adenosylhomocysteinase	IC50	1.5	nM	10.1016/j.bmcl.2014.04.034
Homo sapiens	Adenosylhomocysteinase	IC50	7.2	nM	10.1016/S0960-894X(01)81249-X
Homo sapiens	Adenosylhomocysteinase	IC50	10.0	nM	10.1016/j.bmcl.2014.04.034
Homo sapiens	Adenosylhomocysteinase	IC50	470.0	nM	10.1021/acs.jmedchem.5b00553
Homo sapiens	Adenosylhomocysteinase	IC50	870.0	nM	10.1021/jm1010836
Homo sapiens	Adenosylhomocysteinase	IC50	890.0	nM	10.1016/j.bmcl.2004.02.039
Homo sapiens	Adenosylhomocysteinase	IC50	900.0	nM	10.1016/j.bmc.2009.07.061
Homo sapiens	Adenosylhomocysteinase	IC50	nan	nM	10.1021/jm00117a011
Homo sapiens	Adenosylhomocysteinase	Inhibition	0.05	%	10.1021/jm0004446
Homo sapiens	Adenosylhomocysteinase	Inhibition	2.61	%	10.1021/jm0004446
Homo sapiens	Adenosylhomocysteinase	Inhibition	7.91	%	10.1021/jm0004446
Homo sapiens	Adenosylhomocysteinase	Inhibition	21.83	%	10.1021/jm0004446
Homo sapiens	Adenosylhomocysteinase	k2	1.98	min-1	10.1021/jm00088a013
Homo sapiens	Adenosylhomocysteinase	Ki	3.8	nM	10.1021/jm00088a013
Homo sapiens	Adenosylhomocysteinase	Ki	3.8	nM	10.1021/jm00117a011
Homo sapiens	Adenosylhomocysteinase	Ki	3.8	nM	10.1021/jm00398a002
Homo sapiens	Adenosylhomocysteinase	NAD content	0.0	M (M of enzyme)-1	10.1021/jm00398a002
Homo sapiens	CCRF-CEM	IC50	1.12	ug.mL-1	10.1021/jm960145+
Homo sapiens	CCRF-CEM	IC50	1200.0	nM	10.1021/jm010256v
Homo sapiens	E6SM	CC50	0.7	ug.mL-1	10.1021/jm950853f
Homo sapiens	E6SM	CC50	7.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	E6SM	CC50	40.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	E6SM	CC50	70.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	E6SM	IC50	0.4	ug.mL-1	10.1021/jm960145+
Homo sapiens	E6SM	IC50	0.7	ug.mL-1	10.1021/jm960145+
Homo sapiens	E6SM	IC50	7.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	E6SM	IC50	20.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	E6SM	IC50	40.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	E6SM	IC50	70.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	E6SM	MIC	0.2	ug.mL-1	10.1021/jm00096a012
Homo sapiens	E6SM	MIC	4.0	ug.mL-1	10.1021/jm00096a012
Homo sapiens	E6SM	MIC	40.0	ug.mL-1	10.1021/jm00096a012
Homo sapiens	E6SM	MIC50	0.2	ug.mL-1	10.1021/jm00006a023
Homo sapiens	E6SM	MIC50	0.2	ug.mL-1	10.1021/jm00030a014
Homo sapiens	E6SM	MIC50	0.2	ug.mL-1	10.1021/jm00035a020
Homo sapiens	E6SM	MIC50	2.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	E6SM	MIC50	2.0	ug.mL-1	10.1021/jm00030a014
Homo sapiens	E6SM	MIC50	2.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	E6SM	MIC50	20.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	E6SM	MIC50	20.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	E6SM	MIC50	70.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	E6SM	MIC50	70.0	ug.mL-1	10.1021/jm00030a014
Homo sapiens	E6SM	MIC50	70.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	E6SM	MIC50	100.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	E6SM	MIC50	100.0	ug.mL-1	10.1021/jm00030a014
Homo sapiens	E6SM	MIC50	100.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	HCT-116	IC50	900.0	nM	10.1021/acs.jmedchem.5b00553
Homo sapiens	HCT-116	IC50	1450.0	nM	10.1016/j.ejmech.2018.06.003
Homo sapiens	HEL	CC50	0.3	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	CC50	0.4	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	CC50	7.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	CC50	9.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	CC50	10.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	CC50	15.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	CC50	20.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HEL	IC50	0.2	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HEL	IC50	0.3	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HEL	IC50	0.3	ug.mL-1	10.1021/jm960145+
Homo sapiens	HEL	IC50	2.0	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HEL	IC50	5.0	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HEL	IC50	8.0	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HEL	IC50	9.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	HEL	IC50	10.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	HEL	IC50	16.0	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HEL	IC50	20.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	HEL	MIC	0.4	ug.mL-1	10.1021/jm00096a012
Homo sapiens	HEL	MIC	5.0	ug.mL-1	10.1021/jm00096a012
Homo sapiens	HEL	MIC	8.0	ug.mL-1	10.1021/jm00096a012
Homo sapiens	HEL	MIC50	0.2	ug.mL-1	10.1021/jm00030a014
Homo sapiens	HEL	MIC50	0.4	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HEL	MIC50	0.4	ug.mL-1	10.1021/jm00035a020
Homo sapiens	HEL	MIC50	0.6	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HEL	MIC50	0.6	ug.mL-1	10.1021/jm00035a020
Homo sapiens	HEL	MIC50	1.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	HEL	MIC50	3.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HEL	MIC50	3.5	ug.mL-1	10.1021/jm00030a014
Homo sapiens	HEL	MIC50	4.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HEL	MIC50	5.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HEL	MIC50	6.0	ug.mL-1	10.1021/jm00030a014
Homo sapiens	HEL	MIC50	6.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	HEL	MIC50	20.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HeLa	CC50	2.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HeLa	CC50	40.0	ug.mL-1	10.1021/jm950853f
Homo sapiens	HeLa	IC50	0.2	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HeLa	IC50	2.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	HeLa	IC50	20.0	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HeLa	IC50	40.0	ug.mL-1	10.1021/jm00080a018
Homo sapiens	HeLa	IC50	40.0	ug.mL-1	10.1021/jm960145+
Homo sapiens	HeLa	MIC	0.2	ug.mL-1	10.1021/jm00096a012
Homo sapiens	HeLa	MIC	10.0	ug.mL-1	10.1021/jm00096a012
Homo sapiens	HeLa	MIC	40.0	ug.mL-1	10.1021/jm00096a012
Homo sapiens	HeLa	MIC50	0.2	ug.mL-1	10.1021/jm00030a014
Homo sapiens	HeLa	MIC50	1.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HeLa	MIC50	2.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HeLa	MIC50	2.0	ug.mL-1	10.1021/jm00030a014
Homo sapiens	HeLa	MIC50	2.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	HeLa	MIC50	10.0	ug.mL-1	10.1021/jm00030a014
Homo sapiens	HeLa	MIC50	40.0	ug.mL-1	10.1021/jm00006a023
Homo sapiens	HeLa	MIC50	40.0	ug.mL-1	10.1021/jm00035a020
Homo sapiens	Homo sapiens	Cytotoxicity	0.0	None	10.1021/jm00105a064
Homo sapiens	Homo sapiens	Cytotoxicity	340.0	None	10.1021/jm00105a064
Homo sapiens	Homo sapiens	Cytotoxicity	400.0	None	10.1021/jm00105a064
Homo sapiens	KATO III stomach cancer cell line	IC50	220.0	nM	10.1021/jm010374i
Homo sapiens	MCF7	IC50	25000.0	nM	10.1016/j.bmc.2015.07.045
Homo sapiens	MDA-MB-231	IC50	400.0	nM	10.1021/acs.jmedchem.5b00553
Homo sapiens	MDA-MB-231	IC50	860.0	nM	10.1016/j.ejmech.2018.06.003
Homo sapiens	MDA-MB-231	IC50	25000.0	nM	10.1016/j.bmc.2015.07.045
Homo sapiens	MOLT-4	IC50	2.34	ug.mL-1	10.1021/jm960145+
Homo sapiens	MT4	IC50	0.006	ug.mL-1	10.1021/jm00080a018
Homo sapiens	MT4	IC50	0.02	ug.mL-1	10.1021/jm00080a018
Homo sapiens	PC-3	IC50	2140.0	nM	10.1016/j.ejmech.2018.06.003
Homo sapiens	PC-3	IC50	3700.0	nM	10.1021/acs.jmedchem.5b00553
Homo sapiens	PO3	Cytotoxicity	80.0	None	10.1021/jm00105a064
Homo sapiens	SK-HEP1	IC50	2360.0	nM	10.1016/j.ejmech.2018.06.003
Homo sapiens	SNU-638	IC50	820.0	nM	10.1016/j.ejmech.2018.06.003
Human alphaherpesvirus 1	Human alphaherpesvirus 1	Activity	nan	None	10.1021/jm00385a032
Human alphaherpesvirus 2	Human alphaherpesvirus 2	Activity	nan	None	10.1021/jm00385a032
Human alphaherpesvirus 2	Human alphaherpesvirus 2	VR	1.39	None	10.1021/jm00389a015
Human betaherpesvirus 5	Human betaherpesvirus 5	EC50	0.2	ug.mL-1	10.1016/0960-894X(95)00270-4
Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	100.0	nM	10.1021/jm010256v
Human respirovirus 3	Human respirovirus 3	VR	1.6	None	10.1021/jm00389a015
Influenza A virus	Influenza A virus	EC50	20.0	ug.mL-1	10.1016/0960-894X(95)00270-4
Influenza B virus	Influenza B virus	EC50	20.0	ug.mL-1	10.1016/0960-894X(95)00270-4
Measles morbillivirus	Measles morbillivirus	IC50	0.1	ug.mL-1	10.1021/jm960145+
Measles morbillivirus	Measles morbillivirus	VR	0.75	None	10.1021/jm00389a015
Mumps orthorubulavirus	Mumps virus	IC50	0.11	ug.mL-1	10.1021/jm960145+
Mus musculus	Adenosylhomocysteinase	IC50	50.0	nM	10.1021/jm00117a011
Mus musculus	Adenosylhomocysteinase	Ki	3.0	nM	10.1021/jm00030a014
Mus musculus	FM3A	IC50	0.022	ug.mL-1	10.1021/jm960145+
Mus musculus	L1210	Cytotoxicity	500.0	None	10.1021/jm00105a064
Mus musculus	L1210	IC50	0.027	ug.mL-1	10.1021/jm960145+
Mus musculus	L1210	ID50	1.0	M	10.1021/jm00385a032
Mus musculus	L1210	Inhibition	50.0	%	10.1021/jm00385a032
Mus musculus	L929	IC50	5.2	nM	10.1021/jm00030a014
Mus musculus	MC-38	Cytotoxicity	0.0	None	10.1021/jm00105a064
Plasmodium berghei	Plasmodium berghei	Parasitemia	12.0	%	10.1021/jm010374i
Plasmodium berghei	Plasmodium berghei	Parasitemia	20.0	%	10.1021/jm010374i
Plasmodium berghei	Plasmodium berghei	Parasitemia	21.0	%	10.1021/jm010374i
Plasmodium falciparum	Plasmodium falciparum	IC50	200.0	nM	10.1021/jm010374i
Punta Toro virus	Punta Toro virus	EC50	nan	None	10.1016/j.bmc.2006.10.043
Punta Toro virus	Punta Toro virus	IC50	nan	None	10.1016/j.bmc.2006.10.043
Rattus norvegicus	Adenosylhomocysteinase	Ki	8.39	nM	10.1021/acs.jmedchem.9b01877
Respiratory syncytial virus	Respiratory syncytial virus	MIC50	1.0	ug.mL-1	10.1021/jm00035a020
Respiratory syncytial virus	Respiratory syncytial virus	MIC50	1.2	ug.mL-1	10.1021/jm00006a023
Respiratory syncytial virus	Respiratory syncytial virus	MIC50	1.2	ug.mL-1	10.1021/jm00030a014
Severe acute respiratory syndrome-related coronavirus	SARS-CoV	EC50	nan	None	10.1016/j.bmc.2006.10.043
Severe acute respiratory syndrome-related coronavirus	SARS-CoV	IC50	nan	None	10.1016/j.bmc.2006.10.043
Vaccinia virus	Vaccinia virus	IC50	80.0	nM	10.1021/jm00117a011
Vaccinia virus	Vaccinia virus	VR	1.38	None	10.1021/jm00389a015
Vesicular stomatitis virus	Vesicular stomatitis virus	Activity	nan	None	10.1021/jm00385a032
Vesicular stomatitis virus	Vesicular stomatitis virus	EC50	0.38	ug.mL-1	10.1016/0960-894X(95)00270-4
Vesicular stomatitis virus	Vesicular stomatitis virus	IC50	0.25	ug.mL-1	10.1021/jm960145+
West Nile virus	West Nile virus	EC50	51000.0	nM	10.1016/j.bmc.2006.10.043
West Nile virus	West Nile virus	EC50	51000.0	nM	10.1021/jm010256v
West Nile virus	West Nile virus	IC50	nan	None	10.1016/j.bmc.2006.10.043
None	ADMET	IC50	40.0	ug.mL-1	10.1021/jm00080a018
None	ADMET	IC50	44600.0	nM	10.1021/jm010256v
None	ADMET	Therapeutic index	0.2	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	1.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	12.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	71.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	161.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	230.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	271.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	360.0	None	10.1016/s0960-894x(02)00841-7
None	ADMET	Therapeutic index	1667.0	None	10.1016/s0960-894x(02)00841-7
None	ESM	IC50	0.2	ug.mL-1	10.1021/jm00080a018
None	ESM	IC50	4.0	ug.mL-1	10.1021/jm00080a018
None	ESM	IC50	7.0	ug.mL-1	10.1021/jm00080a018
None	ESM	IC50	10.0	ug.mL-1	10.1021/jm00080a018
None	ESM	IC50	20.0	ug.mL-1	10.1021/jm00080a018
None	ESM	IC50	40.0	ug.mL-1	10.1021/jm00080a018
None	NON-PROTEIN TARGET	Cytotoxicity	40.0	None	10.1021/jm00105a064
None	NON-PROTEIN TARGET	Cytotoxicity	100.0	None	10.1021/jm00105a064
None	NON-PROTEIN TARGET	EC50	0.1	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	EC50	0.26	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	EC50	2.62	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	EC50	100.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	IC50	23.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	IC50	31.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	IC50	36.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	IC50	42.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	IC50	100.0	ug.mL-1	10.1016/s0960-894x(02)00841-7
None	NON-PROTEIN TARGET	IC50	700.0	nM	10.1021/acs.jmedchem.5b00553
None	NON-PROTEIN TARGET	IC50	4500.0	nM	10.1021/acs.jmedchem.5b00553
None	NON-PROTEIN TARGET	IC50	25000.0	nM	10.1016/j.bmc.2015.07.045
None	NON-PROTEIN TARGET	Selectivity index	1.1	None	10.1016/S0960-894X(01)80163-3
None	NON-PROTEIN TARGET	Survival	0.0	None	10.1021/jm010374i
None	NON-PROTEIN TARGET	Survival	5.0	None	10.1021/jm010374i
None	PRK	IC50	0.2	ug.mL-1	10.1021/jm00080a018
None	PRK	IC50	40.0	ug.mL-1	10.1021/jm00080a018
None	Unchecked	EC50	5.0	mg kg-1 day-1	10.1021/jm010374i
None	Unchecked	IC50	0.9	nM	10.1016/j.bmc.2014.07.051
None	Unchecked	Inhibition	30.0	%	10.1039/D1MD00167A
None	Unchecked	k2/KI	0.52	nM-1 min-1	10.1021/jm00088a013