Juziphine
AlkaPlorer ID: AK011249
Synonym: 'Yuziphine', '(+)-Juziphine'
IUPAC Name: (1S)-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-8-ol
Structure
SMILES: COC1=C(O)C2=C(C=C1)CCN(C)[C@H]2CC1=CC=C(O)C=C1
InChI: InChI=1S/C18H21NO3/c1-19-10-9-13-5-8-16(22-2)18(21)17(13)15(19)11-12-3-6-14(20)7-4-12/h3-8,15,20-21H,9-11H2,1-2H3/t15-/m0/s1
InChIKey: QRKWLDOOAQAGAE-HNNXBMFYSA-N
Reference
Chemical investigation of drug-like compounds from the Australian tree, Neolitsea dealbata
PubChem CID: 14526074
LOTUS: LTS0174107
SuperNatural Ⅲ: SN0313199-01
NPASS: NPC103379
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Nectandra | Lauraceae | Laurales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| Neolitsea dealbata | Neolitsea | Lauraceae | Laurales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 299.36999999999995
TPSA？: 52.93000000000001
MolLogP？: 2.8781000000000008
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 4.09 | ug.mL-1 | 10.1021/np960195h |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 4.48 | ug.mL-1 | 10.1021/np960195h |