1-methyl-2-phenylquinolin-4(1H)-one
AlkaPlorer ID: AK011375
Synonym: 'MLS000106879', 'MLSMR', 'SMR000111255'
IUPAC Name: 1-methyl-2-phenylquinolin-4-one
Structure
SMILES: CN1C(C2=CC=CC=C2)=CC(=O)C2=CC=CC=C21
InChI: InChI=1S/C16H13NO/c1-17-14-10-6-5-9-13(14)16(18)11-15(17)12-7-3-2-4-8-12/h2-11H,1H3
InChIKey: AFKNCQDBTBDPOQ-UHFFFAOYSA-N
Reference
An investigation of the alkaloids of the fruit ofHaplophyllum foliosum
PubChem CID: 776143
CAS: 17182-60-4
LOTUS: LTS0219286
SuperNatural Ⅲ: SN0004210
COCONUT: CNP0115094
data_source: manually
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Haplophyllum griffithianum | Haplophyllum | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 235.286
TPSA？: 22.0
MolLogP？: 3.2055000000000016
Number of H-Donors: 0
Number of H-Acceptors: 2
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bos taurus | Tubulin beta chain | IC50 | 40000.0 | nM | 10.1021/jm00061a005 |
| Homo sapiens | 15-hydroxyprostaglandin dehydrogenase [NAD+] | Potency | 25118.9 | nM | None |
| Homo sapiens | A549 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | Ataxin-2 | Potency | 11220.2 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 89125.1 | nM | None |
| Homo sapiens | Guanine nucleotide-binding protein G(s), subunit alpha | Potency | 891.3 | nM | None |
| Homo sapiens | HCT-8 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | KB | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Homo sapiens | RPMI-7951 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Human immunodeficiency virus 1 | Aberrant vpr protein | Potency | 6309.6 | nM | None |
| Mus musculus | P388 | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 4653.5 | nM | None |
| Sus scrofa | Tubulin alpha chain | IC50 | 40000.0 | nM | 10.1021/jm0101085 |
| None | L1210 (1565) | EC50 | 10.0 | ug.mL-1 | 10.1021/jm00061a005 |
| None | Unchecked | Kd | 1000000.0 | nM | 10.1016/j.bmcl.2010.11.110 |