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name Structure Reference Source Properties Activities Metabolism

Trichostatin

AlkaPlorer ID: AK011860

Synonym: None

IUPAC Name: (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Structure

SMILES: CC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1

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InChI: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

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InChIKey: RTKIYFITIVXBLE-QEQCGCAPSA-N

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Properties Information

Molecule Weight: 302.374

TPSA？: 69.64

MolLogP？: 2.579300000000001

Number of H-Donors: 2

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Histone deacetylase-like amidohydrolase IC50 1200.0 nM 10.1016/j.bmcl.2009.04.102
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) Histone deacetylase-like amidohydrolase Ki 700.0 nM 10.1016/j.bmcl.2009.04.102
Chlorocebus sabaeus Vero IC50 0.095 ug.mL-1 10.1016/j.bmc.2009.10.042
Cryptococcus gattii Cryptococcus bacillisporus Activity nan None 10.1128/aac.00153-10
Danio rerio Danio rerio Activity nan None 10.1016/j.ejmech.2018.11.020
Danio rerio Danio rerio Inhibition nan % 10.1038/nchembio.147
Enterovirus Enterovirus IC50 600.0 nM 10.1039/C3MD00371J
Equus caballus Ferritin light chain Potency 35481.3 nM None
Homo sapiens 78 kDa glucose-regulated protein Potency 1258.9 nM None
Homo sapiens 78 kDa glucose-regulated protein Potency 12589.3 nM None
Homo sapiens A2058 IC50 430.0 nM 10.1016/j.bmcl.2020.126952
Homo sapiens A2780 IC50 220.0 nM 10.1021/jm301254q
Homo sapiens A2780 IC50 290.0 nM 10.1021/jm301254q
Homo sapiens A-431 IC50 180.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens A549 Activity nan None 10.1016/j.ejmech.2015.04.001
Homo sapiens A549 Activity nan None 10.1021/acs.jnatprod.1c00324
Homo sapiens A549 GI50 80.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens A549 IC50 20.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens A549 IC50 50.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens A549 IC50 50.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens A549 IC50 50.0 nM 10.1039/C3MD00371J
Homo sapiens A549 IC50 80.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens A549 IC50 80.0 nM 10.1021/jm030377q
Homo sapiens A549 IC50 80.0 nM 10.1021/jm7011408
Homo sapiens A549 IC50 160.0 nM 10.1021/jm020154k
Homo sapiens A549 IC50 1310.0 nM 10.1016/j.bmcl.2020.126952
Homo sapiens A549 IC50 4500.0 nM 10.1021/jm020377a
Homo sapiens ADAM17 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Arylamine N-acetyltransferase 1 FC 1.5 None 10.1124/dmd.110.036202
Homo sapiens Arylamine N-acetyltransferase 1 FC 3.2 None 10.1124/dmd.110.036202
Homo sapiens Arylamine N-acetyltransferase 1 FC 4.1 None 10.1124/dmd.110.036202
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 629.1 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 11186.8 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 14083.4 nM None
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 20596.8 nM None
Homo sapiens Bel-7402 IC50 100.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens Beta-glucocerebrosidase Potency 17782.8 nM None
Homo sapiens BGC-823 IC50 70.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens BT-474 IC50 33.3 nM 10.1016/j.bmc.2021.116510
Homo sapiens BXPC-3 GI50 100.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens C180-13S IC50 60.0 nM 10.1021/jm030222i
Homo sapiens Coagulation factor III IC50 20.0 nM 10.1074/jbc.m703586200
Homo sapiens Coagulation factor III IC50 30.0 nM 10.1074/jbc.m703586200
Homo sapiens Coagulation factor III IC50 50.0 nM 10.1074/jbc.m703586200
Homo sapiens Coagulation factor III Inhibition 91.0 % 10.1074/jbc.m703586200
Homo sapiens Coagulation factor III Inhibition 95.0 % 10.1074/jbc.m703586200
Homo sapiens Cystic fibrosis transmembrane conductance regulator Inhibition nan % 10.1038/nchembio.275
Homo sapiens DMS-53 IC50 25.0 nM 10.1021/np1006718
Homo sapiens DO4 IC50 90.0 nM 10.1021/jm030222i
Homo sapiens DU-145 GI50 nan None 10.1016/j.bmc.2018.02.042
Homo sapiens DU-145 IC50 60.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens DU-145 IC50 60.0 nM 10.1021/jm030222i
Homo sapiens DU-145 IC50 200.0 nM 10.1021/jm020154k
Homo sapiens DU-145 IC50 3500.0 nM 10.1021/jm020377a
Homo sapiens Estrogen receptor alpha Activity nan None None
Homo sapiens Estrogen receptor beta Activity nan None None
Homo sapiens Glucocorticoid receptor Activity nan None None
Homo sapiens H4 Activity 40.15 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 636.52 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 864.85 % 10.1073/pnas.0709695104
Homo sapiens H4 Activity 1649.69 % 10.1073/pnas.0709695104
Homo sapiens HCT-116 EC50 1000.0 nM 10.1016/s0960-894x(01)00552-2
Homo sapiens HCT-116 EC50 1000.0 nM 10.1021/jm0303094
Homo sapiens HCT-116 GI50 35.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens HCT-116 GI50 35.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens HCT-116 GI50 nan None 10.1016/j.bmc.2018.02.042
Homo sapiens HCT-116 IC50 1.3 nM 10.1016/j.bmcl.2006.07.080
Homo sapiens HCT-116 IC50 13.0 nM 10.1021/jm015568c
Homo sapiens HCT-116 IC50 13.0 nM 10.1021/jm030235w
Homo sapiens HCT-116 IC50 43.0 nM 10.1021/jm101092u
Homo sapiens HCT-116 IC50 50.0 nM 10.1021/jm020154k
Homo sapiens HCT-116 IC50 800.0 nM 10.1016/j.bmc.2010.04.033
Homo sapiens HCT-116 IC50 900.0 nM 10.1021/jm020377a
Homo sapiens HCT-116 IC50 nan None 10.1016/j.bmcl.2011.08.022
Homo sapiens HEK293 Activity nan None 10.1016/j.bmcl.2007.06.006
Homo sapiens HEK293 Fold change 2.0 None 10.1016/j.bmcl.2007.06.006
Homo sapiens HEK293 IC50 160.0 nM 10.1016/j.bmcl.2014.12.030
Homo sapiens HeLa Activity -0.46 /hr 10.1124/dmd.110.036202
Homo sapiens HeLa Activity nan None 10.1021/acs.jnatprod.1c00324
Homo sapiens HeLa Activity nan None 10.1038/nchembio.2007.18
Homo sapiens HeLa Activity nan None 10.1124/dmd.110.036202
Homo sapiens HeLa EC1000 0.0115 uM 10.1016/j.bmcl.2008.03.053
Homo sapiens HeLa FC 5.0 None 10.1124/dmd.110.036202
Homo sapiens HeLa FC 18.0 None 10.1124/dmd.110.036202
Homo sapiens HeLa FC 25.0 None 10.1124/dmd.110.036202
Homo sapiens HeLa FC 45.0 None 10.1124/dmd.110.036202
Homo sapiens HeLa IC50 39.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens HeLa IC50 90.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens HeLa IC50 100.0 nM 10.1039/C3MD00371J
Homo sapiens HeLa IC50 110.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens HeLa IC50 850.0 nM 10.1016/j.bmcl.2014.12.030
Homo sapiens HepG2 IC50 380.0 nM 10.1016/j.bmcl.2020.126952
Homo sapiens HepG2 IC50 960.0 nM 10.1016/j.bmcl.2014.12.030
Homo sapiens Histone deacetylase AC50 400.0 nM 10.1021/jm015568c
Homo sapiens Histone deacetylase Activity 0.17 % 10.1016/j.bmc.2023.117300
Homo sapiens Histone deacetylase Activity 1.1 % 10.1016/j.ejmech.2019.03.048
Homo sapiens Histone deacetylase Activity 7.3 % 10.1016/j.ejmech.2019.03.048
Homo sapiens Histone deacetylase Activity 46.6 % 10.1016/j.ejmech.2019.03.048
Homo sapiens Histone deacetylase Activity nan None 10.1021/jm9002439
Homo sapiens Histone deacetylase Activity nan None 10.1038/nchembio815
Homo sapiens Histone deacetylase Activity nan None 10.1074/jbc.m703586200
Homo sapiens Histone deacetylase FC 3.0 None 10.1016/j.ejmech.2018.12.037
Homo sapiens Histone deacetylase FC 10.0 None 10.1016/j.ejmech.2018.12.037
Homo sapiens Histone deacetylase Fold change 3.5 None 10.1016/j.bmcl.2007.06.006
Homo sapiens Histone deacetylase IC50 1.42 nM 10.1021/acs.jnatprod.5b00700
Homo sapiens Histone deacetylase IC50 1.5 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase IC50 3.0 nM 10.1016/j.ejmech.2011.04.027
Homo sapiens Histone deacetylase IC50 3.0 nM 10.1021/jm900850t
Homo sapiens Histone deacetylase IC50 3.3 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase IC50 3.4 nM 10.1016/j.bmcl.2003.09.007
Homo sapiens Histone deacetylase IC50 4.6 nM 10.1021/jm980565u
Homo sapiens Histone deacetylase IC50 5.0 nM 10.1016/j.bmc.2008.03.050
Homo sapiens Histone deacetylase IC50 5.0 nM 10.1016/j.bmc.2009.10.042
Homo sapiens Histone deacetylase IC50 5.0 nM 10.1016/j.bmcl.2004.03.012
Homo sapiens Histone deacetylase IC50 7.2 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase IC50 7.5 nM 10.1016/j.bmcl.2014.10.019
Homo sapiens Histone deacetylase IC50 12.0 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase IC50 12.0 nM 10.1039/C4MD00211C
Homo sapiens Histone deacetylase IC50 15.0 nM 10.1016/j.bmc.2010.10.049
Homo sapiens Histone deacetylase IC50 20.0 nM 10.1016/j.bmc.2010.03.022
Homo sapiens Histone deacetylase IC50 26.0 nM 10.1021/acs.jnatprod.1c00324
Homo sapiens Histone deacetylase IC50 26.0 nM 10.1021/jm015568c
Homo sapiens Histone deacetylase IC50 26.0 nM 10.1021/jm030235w
Homo sapiens Histone deacetylase IC50 28.9 nM 10.1016/j.bmcl.2009.07.068
Homo sapiens Histone deacetylase IC50 41.0 nM 10.1021/jm061082q
Homo sapiens Histone deacetylase IC50 53.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase IC50 53.29 nM 10.1021/jm030377q
Homo sapiens Histone deacetylase IC50 54.5 nM 10.1021/jm0497592
Homo sapiens Histone deacetylase IC50 100.0 nM 10.1021/jm015568c
Homo sapiens Histone deacetylase IC50 250.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase IC50 300.0 nM 10.1016/j.bmcl.2009.04.102
Homo sapiens Histone deacetylase IC50 300.0 nM 10.1021/jm7011408
Homo sapiens Histone deacetylase IC50 430.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase Inhibition 0.0035 uM 10.1016/j.bmcl.2005.01.006
Homo sapiens Histone deacetylase Inhibition 90.0 % 10.1016/j.bmcl.2009.07.068
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.bmcl.2016.03.010
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2010.10.012
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2017.09.075
Homo sapiens Histone deacetylase Inhibition nan % 10.1016/j.ejmech.2022.114115
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/acsmedchemlett.8b00099
Homo sapiens Histone deacetylase Inhibition nan % 10.1021/np800694b
Homo sapiens Histone deacetylase Inhibition nan % 10.1038/nchembio.275
Homo sapiens Histone deacetylase Inhibition nan % 10.1038/nchembio815
Homo sapiens Histone deacetylase Ki 504.0 nM 10.1016/j.bmc.2009.05.042
Homo sapiens Histone deacetylase 1 Activity 0.02 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 1 Activity 0.04 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 0.49 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 1.6 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 1.65 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 2.3 % None
Homo sapiens Histone deacetylase 1 Activity 9.29 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 17.36 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 50.84 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 66.03 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 83.29 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity 94.94 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 Activity nan None 10.1016/j.bmc.2007.10.092
Homo sapiens Histone deacetylase 1 Activity nan None 10.1016/j.bmcl.2003.08.083
Homo sapiens Histone deacetylase 1 EC50 1000.0 nM 10.1016/s0960-894x(01)00552-2
Homo sapiens Histone deacetylase 1 EC50 6000.0 nM 10.1021/jm034167p
Homo sapiens Histone deacetylase 1 FC 2.73 None 10.1021/acs.jnatprod.6b00037
Homo sapiens Histone deacetylase 1 FC 7.52 None 10.1021/acs.jnatprod.6b00037
Homo sapiens Histone deacetylase 1 IC50 0.15 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 1 IC50 0.681 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 1 IC50 1.5 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 1 IC50 1.9 nM 10.1016/j.bmc.2007.08.041
Homo sapiens Histone deacetylase 1 IC50 2.0 nM 10.1016/j.bmc.2015.10.004
Homo sapiens Histone deacetylase 1 IC50 2.14 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 2.2 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 1 IC50 2.3 nM 10.1016/j.ejmech.2012.03.009
Homo sapiens Histone deacetylase 1 IC50 3.0 nM 10.1016/j.bmc.2011.06.030
Homo sapiens Histone deacetylase 1 IC50 3.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 1 IC50 3.3 nM 10.1021/jm900850t
Homo sapiens Histone deacetylase 1 IC50 3.511 nM 10.1016/j.bmc.2019.06.036
Homo sapiens Histone deacetylase 1 IC50 3.511 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 1 IC50 3.9 nM 10.1016/j.bmc.2021.116085
Homo sapiens Histone deacetylase 1 IC50 4.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 1 IC50 4.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 1 IC50 4.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 1 IC50 4.3 nM 10.1016/j.bmc.2013.05.002
Homo sapiens Histone deacetylase 1 IC50 4.9 nM 10.1016/j.bmc.2013.06.009
Homo sapiens Histone deacetylase 1 IC50 5.0 nM 10.1016/s0960-894x(01)00552-2
Homo sapiens Histone deacetylase 1 IC50 5.0 nM 10.1021/jm020154k
Homo sapiens Histone deacetylase 1 IC50 5.0 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase 1 IC50 5.0 nM 10.1021/jm301098e
Homo sapiens Histone deacetylase 1 IC50 5.0 nM 10.1021/jm400564j
Homo sapiens Histone deacetylase 1 IC50 5.6 nM 10.1021/acsmedchemlett.9b00561
Homo sapiens Histone deacetylase 1 IC50 6.0 nM 10.1016/j.bmcl.2009.04.102
Homo sapiens Histone deacetylase 1 IC50 6.0 nM 10.1016/j.bmcl.2012.01.053
Homo sapiens Histone deacetylase 1 IC50 6.0 nM 10.1016/j.bmcl.2020.127023
Homo sapiens Histone deacetylase 1 IC50 6.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 1 IC50 6.0 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 1 IC50 6.22 nM 10.1016/j.ejmech.2019.111755
Homo sapiens Histone deacetylase 1 IC50 6.574 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 1 IC50 6.7 nM None
Homo sapiens Histone deacetylase 1 IC50 6.89 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 1 IC50 6.89 nM 10.1016/j.ejmech.2021.113338
Homo sapiens Histone deacetylase 1 IC50 6.9 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens Histone deacetylase 1 IC50 6.96 nM 10.1016/j.ejmech.2020.112086
Homo sapiens Histone deacetylase 1 IC50 7.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 1 IC50 7.12 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 1 IC50 7.12 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 1 IC50 7.4 nM 10.1016/j.bmcl.2014.10.019
Homo sapiens Histone deacetylase 1 IC50 7.7 nM 10.1021/acsmedchemlett.7b00012
Homo sapiens Histone deacetylase 1 IC50 8.22 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 1 IC50 8.41 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 1 IC50 8.5 nM 10.1021/acs.jmedchem.5b01525
Homo sapiens Histone deacetylase 1 IC50 9.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 1 IC50 9.0 nM 10.1021/acs.jmedchem.9b00946
Homo sapiens Histone deacetylase 1 IC50 9.2 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 1 IC50 9.4 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens Histone deacetylase 1 IC50 9.59 nM 10.1016/j.bmc.2021.116454
Homo sapiens Histone deacetylase 1 IC50 9.9 nM 10.1016/j.bmc.2010.04.033
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.bmcl.2010.09.100
Homo sapiens Histone deacetylase 1 IC50 10.0 nM 10.1016/j.ejmech.2018.10.041
Homo sapiens Histone deacetylase 1 IC50 10.9 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1016/j.bmcl.2012.08.006
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1016/j.ejmech.2018.02.011
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1021/acs.jmedchem.8b00151
Homo sapiens Histone deacetylase 1 IC50 12.0 nM 10.1021/np200843k
Homo sapiens Histone deacetylase 1 IC50 12.44 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 1 IC50 12.5 nM 10.1016/j.ejmech.2019.02.032
Homo sapiens Histone deacetylase 1 IC50 15.0 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 1 IC50 15.7 nM 10.1016/j.bmcl.2016.09.011
Homo sapiens Histone deacetylase 1 IC50 15.8 nM 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 1 IC50 16.0 nM 10.1016/j.bmcl.2007.06.038
Homo sapiens Histone deacetylase 1 IC50 16.0 nM 10.1016/j.bmcl.2011.08.022
Homo sapiens Histone deacetylase 1 IC50 17.9 nM 10.1016/j.bmc.2019.115250
Homo sapiens Histone deacetylase 1 IC50 18.8 nM 10.1016/j.bmcl.2016.09.011
Homo sapiens Histone deacetylase 1 IC50 19.0 nM 10.1016/j.bmc.2018.02.042
Homo sapiens Histone deacetylase 1 IC50 20.0 nM 10.1016/j.bmcl.2004.08.016
Homo sapiens Histone deacetylase 1 IC50 20.0 nM 10.1016/j.bmcl.2005.07.048
Homo sapiens Histone deacetylase 1 IC50 21.0 nM 10.1021/jm060554y
Homo sapiens Histone deacetylase 1 IC50 21.0 nM 10.1021/jm7009217
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1016/j.bmc.2014.06.029
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1016/j.bmcl.2009.12.054
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1016/j.bmcl.2012.03.004
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1016/j.bmcl.2016.09.058
Homo sapiens Histone deacetylase 1 IC50 23.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 IC50 24.9 nM 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 1 IC50 26.0 nM 10.1016/j.bmcl.2006.12.117
Homo sapiens Histone deacetylase 1 IC50 32.0 nM 10.1016/j.ejmech.2018.11.020
Homo sapiens Histone deacetylase 1 IC50 36.6 nM 10.1016/j.bmcl.2008.03.053
Homo sapiens Histone deacetylase 1 IC50 62.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 1 IC50 190.0 nM 10.1016/j.bmc.2007.09.021
Homo sapiens Histone deacetylase 1 IC50 3900.0 nM 10.1016/j.bmcl.2010.12.079
Homo sapiens Histone deacetylase 1 IC50 4740.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 1 IC50 25000.0 nM 10.1021/jm020377a
Homo sapiens Histone deacetylase 1 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 1 Inhibition 18.0 % 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 1 Inhibition 99.36 % 10.1016/j.ejmech.2019.02.032
Homo sapiens Histone deacetylase 1 Inhibition 100.0 % 10.1021/acsmedchemlett.8b00099
Homo sapiens Histone deacetylase 1 Inhibition 100.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1021/jm2016182
Homo sapiens Histone deacetylase 1 Ki 0.2 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 1 Ki 0.2 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 1 Ki 0.2 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 1 Ki 0.23 nM 10.1016/j.ejmech.2010.02.030
Homo sapiens Histone deacetylase 1 Ki 0.64 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 1 Ki 0.87 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 1 Ki nan None 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 10 Activity 0.63 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 2.25 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 5.89 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 8.86 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 24.45 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 41.36 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 74.74 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 87.08 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 94.44 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 Activity 94.45 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 IC50 1.61 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 10 IC50 5.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 10 IC50 5.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 10 IC50 5.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 10 IC50 8.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 10 IC50 9.0 nM 10.1021/jm400564j
Homo sapiens Histone deacetylase 10 IC50 11.3 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 10 IC50 20.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 10 IC50 20.1 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 10 IC50 20.1 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 10 IC50 22.8 nM None
Homo sapiens Histone deacetylase 10 IC50 31.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 10 IC50 32.0 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 10 IC50 34.5 nM 10.1021/acs.jmedchem.8b00151
Homo sapiens Histone deacetylase 10 IC50 34.81 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 10 IC50 37.9 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 10 IC50 38.1 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 10 IC50 61.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 10 IC50 71.0 nM 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 10 IC50 nan None 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 10 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 10 Inhibition 63.0 % 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 10 Inhibition 100.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 10 Ki 4.76 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 10 Ki 7.0 nM 10.1016/j.ejmech.2010.02.030
Homo sapiens Histone deacetylase 11 IC50 10.6 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 11 IC50 11.37 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 11 IC50 13.9 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 11 IC50 15.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 11 IC50 15.0 nM 10.1016/j.ejmech.2018.11.020
Homo sapiens Histone deacetylase 11 IC50 15.15 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 11 IC50 15.2 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 11 IC50 17.3 nM 10.1021/jm400564j
Homo sapiens Histone deacetylase 11 IC50 25.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 11 IC50 31.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 11 IC50 2110.0 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 11 IC50 3470.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 11 IC50 6830.0 nM 10.1016/j.ejmech.2021.113971
Homo sapiens Histone deacetylase 11 IC50 10900.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 11 IC50 nan None 10.1016/j.ejmech.2022.114573
Homo sapiens Histone deacetylase 11 IC50 nan None 10.1021/acs.jmedchem.8b00050
Homo sapiens Histone deacetylase 11 Inhibition 32.8 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 11 Inhibition 98.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 11 Ki 401.0 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 1/2/3 IC50 5.9 nM 10.1016/j.bmcl.2016.09.011
Homo sapiens Histone deacetylase 2 Activity 0.07 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 2 Activity 0.39 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 2.13 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 3.0 % None
Homo sapiens Histone deacetylase 2 Activity 3.91 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 6.8 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 18.26 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 33.5 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 64.85 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 80.86 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 96.37 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 Activity 102.09 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 IC50 1.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 2 IC50 1.1 nM 10.1016/j.ejmech.2012.03.009
Homo sapiens Histone deacetylase 2 IC50 2.74 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 2 IC50 4.0 nM 10.1016/j.bmc.2011.06.030
Homo sapiens Histone deacetylase 2 IC50 5.0 nM 10.1021/jm400564j
Homo sapiens Histone deacetylase 2 IC50 6.08 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 2 IC50 10.0 nM 10.1016/j.bmcl.2008.12.045
Homo sapiens Histone deacetylase 2 IC50 10.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 2 IC50 10.51 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 2 IC50 14.0 nM 10.1016/j.bmc.2013.05.002
Homo sapiens Histone deacetylase 2 IC50 14.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 2 IC50 14.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 2 IC50 14.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 2 IC50 14.8 nM None
Homo sapiens Histone deacetylase 2 IC50 15.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 2 IC50 18.0 nM 10.1016/j.bmcl.2012.01.053
Homo sapiens Histone deacetylase 2 IC50 18.7 nM 10.1016/j.bmc.2019.115250
Homo sapiens Histone deacetylase 2 IC50 20.5 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 2 IC50 22.95 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 2 IC50 23.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 2 IC50 23.0 nM 10.1016/j.ejmech.2018.02.011
Homo sapiens Histone deacetylase 2 IC50 23.6 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 2 IC50 24.0 nM 10.1016/j.bmcl.2016.09.058
Homo sapiens Histone deacetylase 2 IC50 25.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 2 IC50 25.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 2 IC50 26.7 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens Histone deacetylase 2 IC50 28.2 nM 10.1016/j.bmcl.2014.10.019
Homo sapiens Histone deacetylase 2 IC50 28.6 nM 10.1016/j.bmc.2021.116454
Homo sapiens Histone deacetylase 2 IC50 32.1 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 2 IC50 39.0 nM 10.1016/j.bmcl.2005.07.048
Homo sapiens Histone deacetylase 2 IC50 39.1 nM 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 2 IC50 39.5 nM 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 2 IC50 46.6 nM 10.1021/acs.jmedchem.8b00151
Homo sapiens Histone deacetylase 2 IC50 52.0 nM 10.1021/acs.jmedchem.5b01525
Homo sapiens Histone deacetylase 2 IC50 68.0 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 2 IC50 96.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 2 IC50 7600.0 nM 10.1016/j.bmcl.2010.12.079
Homo sapiens Histone deacetylase 2 IC50 25800.0 nM 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 2 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 2 Inhibition 48.0 % 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 2 Inhibition 99.2 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 2 Inhibition nan % 10.1021/jm401053m
Homo sapiens Histone deacetylase 2 Ki 0.65 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 2 Ki 0.7 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 2 Ki 0.76 nM 10.1016/j.ejmech.2010.02.030
Homo sapiens Histone deacetylase 2 Ki 1.06 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 2 Ki 3.55 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 2 Ki nan None 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 3 Activity 32.5 % None
Homo sapiens Histone deacetylase 3 IC50 0.6 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 3 IC50 2.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 3 IC50 2.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 3 IC50 2.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 3 IC50 4.01 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 3 IC50 5.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 3 IC50 9.6 nM None
Homo sapiens Histone deacetylase 3 IC50 10.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 3 IC50 10.3 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 3 IC50 10.32 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 3 IC50 10.4 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens Histone deacetylase 3 IC50 10.4 nM 10.1016/j.ejmech.2020.112086
Homo sapiens Histone deacetylase 3 IC50 11.0 nM 10.1021/jm900850t
Homo sapiens Histone deacetylase 3 IC50 14.0 nM 10.1016/j.bmcl.2016.09.058
Homo sapiens Histone deacetylase 3 IC50 14.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 3 IC50 20.0 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 3 IC50 21.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 3 IC50 26.2 nM 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 3 IC50 30.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 3 IC50 31.0 nM 10.1016/j.ejmech.2018.02.011
Homo sapiens Histone deacetylase 3 IC50 37.5 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 3 IC50 37.5 nM 10.1016/j.ejmech.2021.113338
Homo sapiens Histone deacetylase 3 IC50 52.5 nM 10.1021/acs.jmedchem.8b00151
Homo sapiens Histone deacetylase 3 IC50 5200.0 nM 10.1016/j.bmcl.2010.12.079
Homo sapiens Histone deacetylase 3 Inhibition 40.0 % 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 3 Inhibition 94.0 % 10.1039/D1MD00187F
Homo sapiens Histone deacetylase 3 Inhibition 99.8 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 3 Ki 0.5 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 3 Ki 0.5 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 3 Ki 0.58 nM 10.1016/j.ejmech.2010.02.030
Homo sapiens Histone deacetylase 3/NCoR1 Ki 0.54 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Activity 0.95 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 9.0 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 10.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 11.07 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 12.7 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 13.0 nM 10.1016/j.ejmech.2018.11.020
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 15.7 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 25.3 nM 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Ki 0.26 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) Ki 0.84 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 4 Activity 59.23 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 4 EC1000 20.0 nM 10.1016/j.bmcl.2009.12.054
Homo sapiens Histone deacetylase 4 EC50 1000.0 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase 4 EC50 4000.0 nM 10.1021/jm0303094
Homo sapiens Histone deacetylase 4 IC50 2.0 nM 10.1016/j.bmc.2007.08.041
Homo sapiens Histone deacetylase 4 IC50 8.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 4 IC50 12.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 4 IC50 12.07 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 4 IC50 12.1 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 4 IC50 15.0 nM 10.1016/j.bmc.2021.116510
Homo sapiens Histone deacetylase 4 IC50 20.0 nM 10.1016/j.bmcl.2004.08.016
Homo sapiens Histone deacetylase 4 IC50 29.0 nM 10.1016/j.bmcl.2007.06.038
Homo sapiens Histone deacetylase 4 IC50 34.0 nM 10.1016/j.bmc.2014.06.029
Homo sapiens Histone deacetylase 4 IC50 34.0 nM 10.1016/j.bmcl.2012.03.004
Homo sapiens Histone deacetylase 4 IC50 34.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 4 IC50 34.0 nM 10.1021/jm060554y
Homo sapiens Histone deacetylase 4 IC50 34.0 nM 10.1021/jm7009217
Homo sapiens Histone deacetylase 4 IC50 34.8 nM None
Homo sapiens Histone deacetylase 4 IC50 44.0 nM 10.1016/j.bmcl.2009.12.054
Homo sapiens Histone deacetylase 4 IC50 62.9 nM 10.1016/j.bmcl.2008.03.053
Homo sapiens Histone deacetylase 4 IC50 85.0 nM 10.1016/j.bmc.2013.06.009
Homo sapiens Histone deacetylase 4 IC50 122.0 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 4 IC50 200.0 nM 10.1016/j.bmc.2007.09.021
Homo sapiens Histone deacetylase 4 IC50 1000.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 4 IC50 3800.0 nM 10.1016/j.ejmech.2018.10.041
Homo sapiens Histone deacetylase 4 IC50 4420.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 4 IC50 6600.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 4 IC50 7690.0 nM 10.1016/j.bmcl.2010.12.079
Homo sapiens Histone deacetylase 4 IC50 8439.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 4 IC50 9100.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 4 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 4 Inhibition 2.4 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 4 Inhibition 94.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 4 Ki 400.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 4 Ki 980.0 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 4 Ki 1400.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 4 Ki 1400.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 4 Ki 14547.0 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 4 Ki nan None 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 5 IC50 6.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 5 IC50 8.08 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 5 IC50 12.5 nM None
Homo sapiens Histone deacetylase 5 IC50 16.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 5 IC50 16.48 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 5 IC50 16.5 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 5 IC50 776.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 5 IC50 1090.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 5 IC50 1400.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 5 IC50 6155.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 5 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 5 Inhibition 10.8 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 5 Inhibition 95.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 5 Ki 260.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 5 Ki 260.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 5 Ki 4120.0 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 5 Ki nan None 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 6 Activity 0.09 % 10.1016/j.bmc.2023.117300
Homo sapiens Histone deacetylase 6 Activity 0.75 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 1.41 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 1.55 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 1.73 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 1.98 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 4.51 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 5.12 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 6 Activity 15.97 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 34.4 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 50.0 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity 81.61 % 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 Activity nan None 10.1016/j.bmc.2007.10.092
Homo sapiens Histone deacetylase 6 EC50 5.2 nM 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 6 IC50 0.4 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 6 IC50 0.419 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 6 IC50 0.42 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 6 IC50 0.8 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 6 IC50 0.9 nM 10.1021/jm400564j
Homo sapiens Histone deacetylase 6 IC50 1.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 6 IC50 1.0 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 6 IC50 1.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 6 IC50 1.07 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 6 IC50 1.1 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 6 IC50 1.2 nM 10.1021/jm301098e
Homo sapiens Histone deacetylase 6 IC50 1.4 nM None
Homo sapiens Histone deacetylase 6 IC50 1.5 nM 10.1016/j.bmc.2021.116085
Homo sapiens Histone deacetylase 6 IC50 1.5 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 6 IC50 1.56 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 1.6 nM 10.1016/j.bmc.2013.06.009
Homo sapiens Histone deacetylase 6 IC50 1.716 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 6 IC50 1.94 nM 10.1016/j.ejmech.2019.111755
Homo sapiens Histone deacetylase 6 IC50 2.0 nM 10.1016/j.ejmech.2018.10.041
Homo sapiens Histone deacetylase 6 IC50 2.0 nM 10.1021/acs.jmedchem.9b00946
Homo sapiens Histone deacetylase 6 IC50 2.09 nM 10.1016/j.ejmech.2017.11.021
Homo sapiens Histone deacetylase 6 IC50 2.11 nM 10.1016/j.bmc.2021.116454
Homo sapiens Histone deacetylase 6 IC50 2.3 nM 10.1021/acsmedchemlett.7b00012
Homo sapiens Histone deacetylase 6 IC50 2.31 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 6 IC50 2.6 nM 10.1016/j.ejmech.2020.112086
Homo sapiens Histone deacetylase 6 IC50 3.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 6 IC50 3.13 nM 10.1016/j.ejmech.2018.04.046
Homo sapiens Histone deacetylase 6 IC50 3.49 nM 10.1021/acs.jmedchem.8b00151
Homo sapiens Histone deacetylase 6 IC50 3.55 nM 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 6 IC50 3.55 nM 10.1021/acs.jmedchem.7b01404
Homo sapiens Histone deacetylase 6 IC50 4.53 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 6 IC50 4.53 nM 10.1016/j.ejmech.2021.113338
Homo sapiens Histone deacetylase 6 IC50 5.0 nM 10.1016/j.bmcl.2016.09.058
Homo sapiens Histone deacetylase 6 IC50 5.0 nM 10.1016/j.bmcl.2020.127023
Homo sapiens Histone deacetylase 6 IC50 5.0 nM 10.1021/acs.jmedchem.9b01540
Homo sapiens Histone deacetylase 6 IC50 5.56 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 6 IC50 5.9 nM 10.1016/j.ejmech.2018.11.020
Homo sapiens Histone deacetylase 6 IC50 6.0 nM 10.1021/jm900850t
Homo sapiens Histone deacetylase 6 IC50 6.12 nM 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 6 IC50 7.8 nM 10.1016/j.bmcl.2016.09.011
Homo sapiens Histone deacetylase 6 IC50 8.2 nM 10.1016/j.bmcl.2014.10.019
Homo sapiens Histone deacetylase 6 IC50 8.5 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens Histone deacetylase 6 IC50 8.6 nM 10.1021/acs.jmedchem.9b00924
Homo sapiens Histone deacetylase 6 IC50 8.734 nM 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 IC50 8.92 nM 10.1016/j.bmc.2023.117154
Homo sapiens Histone deacetylase 6 IC50 8.922 nM 10.1016/j.bmc.2019.06.036
Homo sapiens Histone deacetylase 6 IC50 9.0 nM 10.1021/acs.jmedchem.1c02067
Homo sapiens Histone deacetylase 6 IC50 9.0 nM 10.1021/acs.jmedchem.5b01525
Homo sapiens Histone deacetylase 6 IC50 9.3 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 6 IC50 10.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 6 IC50 11.1 nM 10.1016/j.ejmech.2021.113874
Homo sapiens Histone deacetylase 6 IC50 13.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 6 IC50 15.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 6 IC50 15.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens Histone deacetylase 6 IC50 16.0 nM 10.1016/j.bmcl.2016.09.011
Homo sapiens Histone deacetylase 6 IC50 16.8 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 6 IC50 16.8 nM 10.1021/acs.jmedchem.0c02210
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.bmcl.2004.08.016
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.bmcl.2008.12.045
Homo sapiens Histone deacetylase 6 IC50 20.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens Histone deacetylase 6 IC50 38.0 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 6 IC50 51.0 nM 10.1016/j.bmc.2011.06.030
Homo sapiens Histone deacetylase 6 IC50 53.0 nM 10.1016/j.bmcl.2007.06.038
Homo sapiens Histone deacetylase 6 IC50 56.0 nM 10.1016/j.bmcl.2010.09.100
Homo sapiens Histone deacetylase 6 IC50 65.0 nM 10.1016/j.bmc.2015.10.004
Homo sapiens Histone deacetylase 6 IC50 65.0 nM 10.1016/j.bmcl.2009.12.054
Homo sapiens Histone deacetylase 6 IC50 65.0 nM 10.1016/j.bmcl.2012.03.004
Homo sapiens Histone deacetylase 6 IC50 81.0 nM 10.1021/jm060554y
Homo sapiens Histone deacetylase 6 IC50 83.3 nM 10.1016/j.bmcl.2008.03.053
Homo sapiens Histone deacetylase 6 IC50 91.0 nM 10.1016/j.bmcl.2005.07.048
Homo sapiens Histone deacetylase 6 IC50 280.0 nM 10.1016/j.bmc.2007.09.021
Homo sapiens Histone deacetylase 6 IC50 600.0 nM 10.1016/j.bmcl.2010.12.079
Homo sapiens Histone deacetylase 6 IC50 1210.0 nM 10.1016/j.ejmech.2018.03.005
Homo sapiens Histone deacetylase 6 IC50 2600.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens Histone deacetylase 6 IC50 3600.0 nM 10.1016/j.bmc.2019.115250
Homo sapiens Histone deacetylase 6 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 6 Inhibition 4.0 % 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 6 Inhibition 81.75 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 98.39 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 100.0 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 6 Inhibition 102.61 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1016/j.bmcl.2015.11.011
Homo sapiens Histone deacetylase 6 Inhibition nan % 10.1021/jm2016182
Homo sapiens Histone deacetylase 6 Ki 0.13 nM 10.1016/j.bmcl.2008.04.007
Homo sapiens Histone deacetylase 6 Ki 0.58 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 6 Ki 0.99 nM 10.1016/j.ejmech.2010.02.030
Homo sapiens Histone deacetylase 6 Ki 1.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 6 Ki 1.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 6 Ki 3.02 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 6 Ki nan None 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 7 Activity 35.37 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 7 FC 2.5 None 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 IC50 22.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 7 IC50 22.46 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 7 IC50 22.5 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 7 IC50 139.0 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 7 IC50 197.0 nM None
Homo sapiens Histone deacetylase 7 IC50 200.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 IC50 482.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 7 IC50 2300.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 7 IC50 4170.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 7 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 7 Inhibition 6.3 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 7 Inhibition 88.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 7 Inhibition nan % 10.1038/nchembio.275
Homo sapiens Histone deacetylase 7 Ki 195.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 7 Ki 195.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 7 Ki 300.0 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 7 Ki nan None 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 8 Activity 5.72 % 10.1016/j.bmc.2013.04.036
Homo sapiens Histone deacetylase 8 Activity 48.2 % None
Homo sapiens Histone deacetylase 8 IC50 1.38 nM 10.1021/jm8002894
Homo sapiens Histone deacetylase 8 IC50 25.0 nM 10.1021/jm900850t
Homo sapiens Histone deacetylase 8 IC50 40.0 nM 10.1016/j.bmcl.2004.08.016
Homo sapiens Histone deacetylase 8 IC50 89.5 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 8 IC50 89.53 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 8 IC50 90.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 8 IC50 100.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 8 IC50 125.0 nM 10.1016/j.ejmech.2018.02.011
Homo sapiens Histone deacetylase 8 IC50 129.0 nM 10.1021/jm400564j
Homo sapiens Histone deacetylase 8 IC50 160.0 nM 10.1016/j.bmc.2015.10.004
Homo sapiens Histone deacetylase 8 IC50 165.0 nM None
Homo sapiens Histone deacetylase 8 IC50 170.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 8 IC50 196.0 nM 10.1021/jm301254q
Homo sapiens Histone deacetylase 8 IC50 232.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 8 IC50 280.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens Histone deacetylase 8 IC50 290.0 nM 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 8 IC50 300.0 nM 10.1016/j.bmc.2010.03.080
Homo sapiens Histone deacetylase 8 IC50 307.4 nM 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 8 IC50 310.0 nM 10.1016/j.bmc.2021.116599
Homo sapiens Histone deacetylase 8 IC50 314.0 nM 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 8 IC50 314.0 nM 10.1016/j.ejmech.2021.113338
Homo sapiens Histone deacetylase 8 IC50 360.0 nM 10.1021/acs.jmedchem.5b01525
Homo sapiens Histone deacetylase 8 IC50 371.0 nM 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 8 IC50 390.0 nM 10.1016/j.bmcl.2012.08.104
Homo sapiens Histone deacetylase 8 IC50 420.0 nM 10.1016/j.ejmech.2021.113569
Homo sapiens Histone deacetylase 8 IC50 427.0 nM 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 8 IC50 490.0 nM 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 8 IC50 566.0 nM 10.1021/acs.jmedchem.8b00151
Homo sapiens Histone deacetylase 8 IC50 609.0 nM 10.1021/acs.jmedchem.8b01487
Homo sapiens Histone deacetylase 8 IC50 650.0 nM 10.1016/j.bmc.2019.115250
Homo sapiens Histone deacetylase 8 IC50 697.0 nM 10.1016/j.bmc.2021.116454
Homo sapiens Histone deacetylase 8 IC50 770.0 nM 10.1016/j.bmcl.2008.12.045
Homo sapiens Histone deacetylase 8 IC50 790.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens Histone deacetylase 8 IC50 820.0 nM 10.1016/j.ejmech.2020.112086
Homo sapiens Histone deacetylase 8 IC50 944.0 nM 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 8 IC50 960.0 nM 10.1016/j.bmc.2011.06.030
Homo sapiens Histone deacetylase 8 IC50 990.0 nM 10.1016/j.ejmech.2018.11.020
Homo sapiens Histone deacetylase 8 IC50 1020.0 nM 10.1016/j.ejmech.2018.03.006
Homo sapiens Histone deacetylase 8 IC50 1160.0 nM 10.1016/j.ejmech.2019.111950
Homo sapiens Histone deacetylase 8 IC50 1360.0 nM 10.1016/j.bmc.2013.05.002
Homo sapiens Histone deacetylase 8 IC50 1380.0 nM 10.1021/jm701606b
Homo sapiens Histone deacetylase 8 IC50 1380.0 nM 10.1021/jm901667k
Homo sapiens Histone deacetylase 8 IC50 4550.0 nM 10.1021/acs.jmedchem.5b01632
Homo sapiens Histone deacetylase 8 IC50 73100.0 nM 10.1016/j.bmcl.2010.12.079
Homo sapiens Histone deacetylase 8 Inhibition 17.9 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 8 Inhibition 90.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 8 Inhibition 95.0 % 10.1039/D1MD00187F
Homo sapiens Histone deacetylase 8 Inhibition 519.0 % 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 8 Inhibition nan % 10.1016/j.ejmech.2019.06.073
Homo sapiens Histone deacetylase 8 Ki 45.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 8 Ki 45.0 nM 10.1016/j.ejmech.2017.09.075
Homo sapiens Histone deacetylase 8 Ki 45.0 nM 10.1038/nchembio.313
Homo sapiens Histone deacetylase 8 Ki 69.65 nM 10.1021/ml400158k
Homo sapiens Histone deacetylase 8 Ki 130.0 nM 10.1016/j.ejmech.2010.02.030
Homo sapiens Histone deacetylase 8 Ki 145.0 nM 10.1021/acs.jmedchem.7b01593
Homo sapiens Histone deacetylase 8 Ki 200.0 nM 10.1039/C5MD00451A
Homo sapiens Histone deacetylase 9 IC50 20.0 nM 10.1038/nchembio.275
Homo sapiens Histone deacetylase 9 IC50 20.1 nM 10.1021/jm2001025
Homo sapiens Histone deacetylase 9 IC50 38.0 nM 10.1016/j.bmcl.2009.02.029
Homo sapiens Histone deacetylase 9 IC50 38.1 nM 10.1016/j.ejmech.2014.04.021
Homo sapiens Histone deacetylase 9 IC50 38.12 nM 10.1021/jm101092u
Homo sapiens Histone deacetylase 9 IC50 70.1 nM None
Homo sapiens Histone deacetylase 9 IC50 1000.0 nM 10.1021/acsmedchemlett.9b00471
Homo sapiens Histone deacetylase 9 IC50 4920.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens Histone deacetylase 9 IC50 5000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1016/j.ejmech.2016.03.046
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1016/j.ejmech.2016.11.033
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1016/j.ejmech.2018.10.066
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1016/j.ejmech.2019.111915
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1016/j.ejmech.2022.114602
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens Histone deacetylase 9 IC50 nan None 10.1021/acs.jmedchem.7b01465
Homo sapiens Histone deacetylase 9 Inhibition 14.4 % 10.1039/c4md00401a
Homo sapiens Histone deacetylase 9 Inhibition 92.0 % 10.1016/j.bmc.2016.08.040
Homo sapiens Histone deacetylase 9 Ki 800.0 nM 10.1016/j.bmc.2014.12.066
Homo sapiens Histone deacetylase 9 Ki 800.0 nM 10.1038/nchembio.313
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 15848.9 nM None
Homo sapiens HK-2 Activity 70.0 % 10.1016/j.ejmech.2022.114115
Homo sapiens HL-60 GI50 590.0 nM 10.1016/j.ejmech.2018.02.011
Homo sapiens HL-60 IC50 30.0 nM 10.1039/C3MD00371J
Homo sapiens HL-60 IC50 80.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens HL-60 IC50 nan None 10.1021/acs.jmedchem.6b00235
Homo sapiens HMEC IC50 1600.0 nM 10.1021/jm020154k
Homo sapiens HMEC IC50 32000.0 nM 10.1021/jm020377a
Homo sapiens HT-1080 IC50 80.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens HT-29 Activity 20.0 % 10.1021/acs.jmedchem.8b00050
Homo sapiens HT-29 GI50 34.1 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens HT-29 IC50 3.8 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens HT-29 IC50 55.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens Huh-7 CC50 1587.0 nM 10.1073/pnas.0802982105
Homo sapiens Huh-7 IC50 60.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens HUVEC Activity nan None 10.1074/jbc.m703586200
Homo sapiens JAM cell line IC50 80.0 nM 10.1021/jm030222i
Homo sapiens K562 GI50 262.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens K562 IC50 90.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens K562 IC50 120.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens K562 IC50 160.0 nM 10.1039/C3MD00371J
Homo sapiens K562 IC50 260.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens K562 IC50 410.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens K562 IC50 560.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens K-562R GI50 88.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens Leukotriene A4 hydrolase Delta Tm 0.17 degrees C 10.1021/acs.jmedchem.6b01507
Homo sapiens Leukotriene A4 hydrolase IC50 10000.0 nM 10.1021/acs.jmedchem.6b01507
Homo sapiens Leukotriene A4 hydrolase Inhibition 50.0 % 10.1021/acs.jmedchem.6b01507
Homo sapiens Lysine-specific demethylase 4D-like IC50 28400.0 nM 10.1021/acs.jmedchem.2c00680
Homo sapiens Matrix metalloproteinase-1 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens Matrix metalloproteinase 14 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens Matrix metalloproteinase-2 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens Matrix metalloproteinase 3 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens Matrix metalloproteinase 7 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens Matrix metalloproteinase 8 Inhibition nan % 10.1039/D1MD00187F
Homo sapiens MCF7 Fold change 0.17 None 10.1016/j.bmcl.2005.01.032
Homo sapiens MCF7 Fold change 0.77 None 10.1016/j.bmcl.2005.01.032
Homo sapiens MCF7 Fold change 0.81 None 10.1016/j.bmcl.2005.01.032
Homo sapiens MCF7 Fold change 1.29 None 10.1016/j.bmcl.2005.01.032
Homo sapiens MCF7 Fold change 1.57 None 10.1016/j.bmcl.2005.01.032
Homo sapiens MCF7 Fold change 3.1 None 10.1016/j.bmcl.2005.01.032
Homo sapiens MCF7 GI50 45.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens MCF7 GI50 nan None 10.1016/j.bmc.2018.02.042
Homo sapiens MCF7 IC50 20.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens MCF7 IC50 20.0 nM 10.1021/jm030222i
Homo sapiens MCF7 IC50 27.7 nM 10.1016/j.bmc.2021.116510
Homo sapiens MCF7 IC50 54.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens MCF7 IC50 60.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens MCF7 IC50 60.0 nM 10.1039/C3MD00371J
Homo sapiens MCF7 IC50 70.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens MCF7 IC50 100.0 nM 10.1021/jm020154k
Homo sapiens MCF7 IC50 141.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens MCF7 IC50 300.0 nM 10.1016/j.bmcl.2020.126952
Homo sapiens MCF7 IC50 1700.0 nM 10.1016/j.ejmech.2012.03.009
Homo sapiens MCF7 IC50 10000.0 nM 10.1021/jm020377a
Homo sapiens MDA-MB-231 Activity nan None 10.1021/acs.jnatprod.1c00324
Homo sapiens MDA-MB-231 IC50 90.0 nM 10.1021/jm020154k
Homo sapiens MDA-MB-231 IC50 91.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens MDA-MB-231 IC50 3500.0 nM 10.1021/jm020377a
Homo sapiens MDA-MB-231 IC50 nan None 10.1021/acs.jmedchem.6b00235
Homo sapiens MDA-MB-435 GI50 1780.0 nM 10.1016/j.ejmech.2018.02.011
Homo sapiens MIA PaCa-2 GI50 200.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens MIA PaCa-2 IC50 200.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens MIA PaCa-2 IC50 900.0 nM 10.1016/j.bmcl.2020.126952
Homo sapiens Microtubule-associated protein tau Potency 35481.3 nM None
Homo sapiens MKN-45 IC50 20.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens MKN-45 IC50 100.0 nM 10.1021/jm030377q
Homo sapiens MKN-45 IC50 100.0 nM 10.1021/jm7011408
Homo sapiens MM96L IC50 30.0 nM 10.1021/jm030222i
Homo sapiens MM96L IC50 30.0 nM 10.1021/jm7011408
Homo sapiens MOLT-4 IC50 20.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens MOLT-4 IC50 30.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens MOLT-4 IC50 30.0 nM 10.1039/C3MD00371J
Homo sapiens NAD-dependent deacetylase sirtuin 2 Activity nan None 10.1021/jm060118b
Homo sapiens NAD-dependent deacetylase sirtuin 2 Activity nan None 10.1021/jm901055u
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Kd 29000.0 nM 10.1021/acs.jmedchem.8b01455
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Kd 33000.0 nM 10.1021/acs.jmedchem.8b01455
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Kd 227000.0 nM 10.1021/acs.jmedchem.8b01455
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Kd 445000.0 nM 10.1021/acs.jmedchem.8b01455
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Ki 2000.0 nM 10.1021/acs.jmedchem.8b01455
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Ki 2020.0 nM 10.1021/acs.jmedchem.1c00601
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Ki 4620.0 nM 10.1021/acs.jmedchem.1c00601
Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Ki 450000.0 nM 10.1021/acs.jmedchem.8b01455
Homo sapiens NCI-H1299 IC50 100.0 nM 10.1021/jm030235w
Homo sapiens NCI-H1975 IC50 90.0 nM 10.1039/C3MD00371J
Homo sapiens NCI-H1975 IC50 210.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens NCI-H358 Potency 40.0 nM None
Homo sapiens NCI-H446 IC50 80.0 nM 10.1021/jm020154k
Homo sapiens NCI-H446 IC50 1500.0 nM 10.1021/jm020377a
Homo sapiens NCI-H460 IC50 100.0 nM 10.1021/jm101092u
Homo sapiens NCI-H661 FC 4.0 None 10.1021/jm9002439
Homo sapiens NCI-H661 FC 50.0 None 10.1021/jm9002439
Homo sapiens NCI-H661 IC50 100.0 nM 10.1021/jm9002439
Homo sapiens NCI-N87 IC50 58.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens NCI-N87 IC50 60.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens NFF IC50 200.0 nM 10.1016/j.ejmech.2018.09.018
Homo sapiens NFF IC50 200.0 nM 10.1021/jm030222i
Homo sapiens NFF IC50 6700.0 nM 10.1021/jm7011408
Homo sapiens NSCLC Potency 40.0 nM None
Homo sapiens NSCLC Potency 100.0 nM None
Homo sapiens PANC-1 IC50 100.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens PC-3 FC 0.268 None 10.1038/nchembio790
Homo sapiens PC-3 GI50 387.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens PC-3 IC50 4999999.95 nM 10.1016/j.bmcl.2003.11.062
Homo sapiens PC-3 IC50 nan None 10.1021/acs.jmedchem.6b00235
Homo sapiens PC-9 Activity nan None 10.1016/j.bmcl.2017.05.063
Homo sapiens Peroxisome proliferator-activated receptor gamma Activity nan None None
Homo sapiens PI3-kinase p110-alpha subunit IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-alpha subunit Inhibition nan % 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-beta subunit IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-beta subunit Inhibition nan % 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-delta subunit IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-delta subunit Inhibition nan % 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-gamma subunit IC50 nan None 10.1021/acs.jmedchem.0c00193
Homo sapiens PI3-kinase p110-gamma subunit Inhibition nan % 10.1021/acs.jmedchem.0c00193
Homo sapiens Pyruvate kinase isozymes M1/M2 Activity nan None 10.1021/acs.jmedchem.1c00981
Homo sapiens Regulator of G-protein signaling 4 Potency 37685.8 nM None
Homo sapiens SGC-7901 IC50 30.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens SH-SY5Y Activity nan None 10.1021/jm400564j
Homo sapiens SK-BR-3 IC50 20.0 nM 10.1016/j.ejmech.2018.08.073
Homo sapiens SK-BR-3 IC50 20.0 nM 10.1021/jm030377q
Homo sapiens SK-BR-3 IC50 20.0 nM 10.1021/jm7011408
Homo sapiens SK-BR-3 IC50 50.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens SK-MEL-28 IC50 280.0 nM 10.1021/jm030222i
Homo sapiens SK-OV-3 IC50 100.0 nM 10.1016/j.ejmech.2022.114573
Homo sapiens Splicing factor 3B subunit 3 Activity 82.4 % 10.1038/nchembio.2007.16
Homo sapiens Splicing factor 3B subunit 3 Activity nan None 10.1038/nchembio.2007.16
Homo sapiens Splicing factor 3B subunit 3 IC50 577.6 nM 10.1038/nchembio.2007.16
Homo sapiens Splicing factor 3B subunit 3 IC50 611.2 nM 10.1038/nchembio.2007.16
Homo sapiens SQ20B IC50 200.0 nM 10.1021/jm7011408
Homo sapiens Survival motor neuron protein Potency 1122.0 nM None
Homo sapiens Survival motor neuron protein Potency 1412.5 nM None
Homo sapiens SW48 IC50 100.0 nM 10.1021/jm020154k
Homo sapiens SW48 IC50 5000.0 nM 10.1021/jm020377a
Homo sapiens SW480 Activity nan None 10.1021/acs.jnatprod.1c00324
Homo sapiens T-24 EC50 10.0 nM 10.1016/j.bmcl.2008.12.045
Homo sapiens T-24 IC50 150.0 nM 10.1021/jm020154k
Homo sapiens T-24 IC50 4000.0 nM 10.1021/jm020377a
Homo sapiens T47D IC50 26.4 nM 10.1016/j.bmc.2021.116510
Homo sapiens U2OS Activity nan None 10.1021/acs.jnatprod.1c00324
Homo sapiens U2OS IC50 14930.0 nM 10.1016/j.bmcl.2014.12.030
Homo sapiens U-87 MG GI50 1038.0 nM 10.1021/acs.jmedchem.8b00050
Homo sapiens U-937 IC50 40.0 nM 10.1021/acs.jmedchem.6b00235
Homo sapiens U-937 IC50 50.0 nM 10.1039/C3MD00371J
Homo sapiens U-937 IC50 100.0 nM 10.1016/j.ejmech.2014.06.030
Homo sapiens Vitamin D receptor IC50 87.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Vitamin D receptor Potency 89125.1 nM None
Human immunodeficiency virus 1 Human immunodeficiency virus 1 Activity 21.3 % 10.1016/j.ejmech.2021.113213
Leishmania donovani Leishmania donovani IC50 1.37 ug.mL-1 10.1016/j.bmc.2009.10.042
Leishmania donovani Leishmania donovani IC90 20.5 ug.mL-1 10.1016/j.bmc.2009.10.042
Mus musculus C2C12 Inhibition nan % 10.1038/nchembio.301
Mus musculus Class 1 histone deacetylase FC 7.99 None 10.1021/acs.jmedchem.0c02210
Mus musculus Histone deacetylase IC50 1.44 nM 10.1021/jm0303094
Mus musculus Histone deacetylase 1 IC50 1.8 nM 10.1021/jm0605536
Mus musculus Histone deacetylase 1 IC50 1.8 nM 10.1021/jm7011408
Mus musculus Histone deacetylase 1 IC50 1.995 nM 10.1021/jm031036f
Mus musculus Histone deacetylase 1 IC50 2.0 nM 10.1021/jm011088+
Mus musculus Histone deacetylase 1 IC50 2.0 nM 10.1021/jm031036f
Mus musculus Histone deacetylase 1 IC50 19.0 nM 10.1016/j.bmcl.2004.03.018
Mus musculus Histone deacetylase 1 Ki 1.072 nM 10.1021/jm011088+
Mus musculus Histone deacetylase 5 IC50 20.0 nM 10.1016/j.bmcl.2004.03.018
Mus musculus Histone deacetylase 6 FC 1.76 None 10.1021/acs.jmedchem.0c02210
Mus musculus Histone deacetylase 6 IC50 2.8 nM 10.1016/j.bmc.2007.08.041
Mus musculus Histone deacetylase 6 IC50 28.0 nM 10.1016/j.bmc.2018.02.042
Mus musculus Histone deacetylase 6 IC50 28.0 nM 10.1016/j.bmcl.2004.03.018
Mus musculus Histone deacetylase 6 IC50 65.0 nM 10.1016/j.bmc.2014.06.029
Mus musculus Histone deacetylase 6 IC50 65.0 nM 10.1016/j.ejmech.2018.08.073
Mus musculus Histone deacetylase 6 IC50 81.0 nM 10.1021/jm7009217
Mus musculus Histone deacetylase 6 Inhibition 98.0 % 10.1021/acsmedchemlett.8b00099
Mus musculus Histone deacetylase 8 IC50 40.0 nM 10.1016/j.bmcl.2004.03.018
Mus musculus Histone deacetylase 8 Inhibition nan % 10.1016/j.bmc.2013.05.002
Mus musculus Mus musculus Activity 8.86 mmol/L 10.1016/j.ejmech.2022.114115
Mus musculus Mus musculus Activity 50.0 % 10.1074/jbc.m703586200
Mus musculus Mus musculus Activity 129.14 mmol/L 10.1016/j.ejmech.2022.114115
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2022.114115
Mus musculus Protein Wnt-3a Activity nan None 10.1016/j.bmc.2008.10.077
Mus musculus Tissue factor Inhibition 60.0 % 10.1074/jbc.m703586200
Mycobacterium tuberculosis Mycobacterium tuberculosis IC50 nan None 10.1039/C3MD00371J
Plasmodium falciparum Histone deacetylase IC50 0.6 nM 10.1021/jm801654y
Plasmodium falciparum Plasmodium falciparum EC50 170.8 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum EC50 200.2 nM 10.1073/pnas.0802982105
Plasmodium falciparum Plasmodium falciparum IC50 0.0412 ug.mL-1 10.1016/j.bmc.2009.10.042
Plasmodium falciparum Plasmodium falciparum IC50 0.0495 ug.mL-1 10.1016/j.bmc.2009.10.042
Plasmodium falciparum Plasmodium falciparum IC50 8.0 nM 10.1016/j.ejmech.2014.05.050
Plasmodium falciparum Plasmodium falciparum IC50 8.0 nM 10.1016/j.ejmech.2018.09.018
Plasmodium falciparum Plasmodium falciparum IC50 8.0 nM 10.1128/aac.00757-07
Plasmodium falciparum Plasmodium falciparum IC50 9.772 nM 10.1016/j.bmc.2008.03.005
Plasmodium falciparum Plasmodium falciparum IC50 10.0 nM 10.1016/j.bmc.2008.03.005
Plasmodium falciparum Plasmodium falciparum IC50 11.0 nM 10.1128/aac.00757-07
Plasmodium falciparum Plasmodium falciparum IC50 15.49 nM 10.1016/j.bmc.2008.03.005
Plasmodium falciparum Plasmodium falciparum IC50 15.6 nM 10.1016/j.bmc.2008.03.005
Plasmodium falciparum Plasmodium falciparum IC50 16.0 nM 10.1021/jm801654y
Plasmodium falciparum Plasmodium falciparum Inhibition nan % 10.1128/aac.00757-07
Plasmodium falciparum 3D7 Histone deacetylase Inhibition nan % 10.1128/aac.00439-08
Rattus norvegicus Histone deacetylase IC50 12.0 nM 10.1016/s0960-894x(03)00284-1
Rattus norvegicus Histone deacetylase IC50 12.0 nM 10.1021/jm0208119
Rattus norvegicus Histone deacetylase IC50 12.0 nM 10.1021/jm0303094
Rattus norvegicus Histone deacetylase IC50 12.0 nM 10.1021/jm0497592
Rattus norvegicus Histone deacetylase IC50 13.3 nM 10.1021/jm0497592
Rattus norvegicus Histone deacetylase IC50 20.4 nM 10.1021/jm0497592
Rattus norvegicus Histone deacetylase IC50 20.7 nM 10.1021/jm0497592
Rattus norvegicus Histone deacetylase IC50 26.0 nM 10.1021/jm0303094
Rattus norvegicus Histone deacetylase IC50 26.3 nM 10.1021/jm0497592
Rattus norvegicus Histone deacetylase IC50 1526.0 nM 10.1021/jm0497592
Rattus norvegicus PC-12 Activity nan None 10.1021/jm400564j
Rattus norvegicus Rattus norvegicus Activity 1.0 g/Kg 10.1021/acs.jmedchem.7b00115
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 50.0 ug.mL-1 10.1021/np1006718
Saccharomyces cerevisiae S288c Ribosome maturation protein SDO1 AC50 0.75 nM None
Schistosoma mansoni Histone deacetylase 8 IC50 3620.0 nM 10.1016/j.bmc.2017.02.020
Schistosoma mansoni Schistosoma mansoni EC50 558.0 nM 10.6019/CHEMBL5096127
Schistosoma mansoni Schistosoma mansoni In vitro activity nan None 10.6019/CHEMBL5096127
Schistosoma mansoni Schistosoma mansoni Worm movement inhibition 8.13 % 10.6019/CHEMBL5096127
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 25.43 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 2.01 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 4.03 % 10.6019/CHEMBL4495565
Toxoplasma gondii Toxoplasma gondii IC50 41.0 nM 10.1021/acs.jmedchem.6b01595
Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 5000.0 nM 10.1016/j.bmc.2014.12.066
Trypanosoma brucei brucei Trypanosoma brucei brucei IC50 7000.0 nM 10.1021/acs.jmedchem.6b01595
Zea mays Histone deacetylase HD1B IC50 0.4 nM 10.1016/j.ejmech.2007.05.004
Zea mays Histone deacetylase HD1B IC50 0.4 nM 10.1021/jm0605536
Zea mays Histone deacetylase HD2 IC50 3.0 nM 10.1021/jm0208119
Zea mays Histone deacetylase HD2 IC50 3.0 nM 10.1021/jm0303094
Zea mays Histone deacetylase HD2 IC50 3.0 nM 10.1021/jm991091h
Zea mays Histone deacetylase HD2 IC50 7.0 nM 10.1021/jm011088+
Zea mays Histone deacetylase HD2 IC50 7.0 nM 10.1021/jm049002a
Zea mays Histone deacetylase HD2 IC50 7.0 nM 10.1021/jm0605536
Zea mays Histone deacetylase HD2 IC50 7.079 nM 10.1021/jm031036f
Zea mays Histone deacetylase HD2 IC50 7.2 nM 10.1021/jm015515v
Zea mays Histone deacetylase HD2 IC50 7.2 nM 10.1021/jm030990+
Zea mays Histone deacetylase HD2 IC50 7.2 nM 10.1021/jm031036f
Zea mays Histone deacetylase HD2 IC50 7.2 nM 10.1021/jm034167p
Zea mays Histone deacetylase HD2 IC90 100.0 nM 10.1016/S0960-894X(97)00284-9
Zea mays Histone deacetylase HD2 Ki 4.365 nM 10.1021/jm011088+
Zea mays Histone deacetylase HD2 Ki 4.365 nM 10.1021/jm015515v
None ADMET Activity 19.0 % 10.1021/acs.jmedchem.6b00670
None ADMET Activity 40.0 % 10.1021/acs.jmedchem.6b00670
None ADMET Activity 170.0 % 10.1021/acs.jmedchem.6b00670
None ADMET Activity nan None 10.1038/nchembio815
None ADMET CL 107.0 mL.min-1.g-1 10.1021/jm8008663
None ADMET IC50 200.0 nM 10.1016/j.ejmech.2014.05.050
None ADMET IC50 200.0 nM 10.1128/aac.00757-07
None ADMET IC50 210.0 nM 10.1016/j.bmcl.2014.12.030
None Fibroblast MRHF cell line IC50 36000.0 nM 10.1021/jm020377a
None Friend leukemia cell line IC50 40.0 nM 10.1021/jm0208119
None Friend leukemia cell line IC50 40.0 nM 10.1021/jm0303094
None Molecular identity unknown Activity nan None 10.1016/j.bmcl.2011.07.053
None NON-PROTEIN TARGET IC50 8.0 nM 10.1039/C3MD00371J
None NON-PROTEIN TARGET IC50 50.0 nM 10.1016/j.bmcl.2012.08.006
None NON-PROTEIN TARGET IC50 80.0 nM 10.1016/j.ejmech.2014.06.030
None NON-PROTEIN TARGET IC50 80.0 nM 10.1039/C3MD00371J
None NON-PROTEIN TARGET IC50 85.0 nM 10.1016/j.bmcl.2007.06.067
None NON-PROTEIN TARGET IC50 85.0 nM 10.1016/j.bmcl.2007.09.041
None NON-PROTEIN TARGET IC50 90.0 nM 10.1039/C3MD00371J
None NON-PROTEIN TARGET IC50 100.0 nM 10.1016/j.bmcl.2006.07.080
None NON-PROTEIN TARGET IC50 100.0 nM 10.1016/j.ejmech.2014.06.030
None NON-PROTEIN TARGET IC50 200.0 nM 10.1021/jm7011408
None NON-PROTEIN TARGET IC50 250.0 nM 10.1021/jm900187v
None NON-PROTEIN TARGET IC50 300.0 nM 10.1016/j.bmcl.2006.07.080
None No relevant target Intrinsic_solubility nan None 10.1016/j.bmc.2013.06.009
None No relevant target LogD nan None 10.1016/j.bmc.2013.06.009
None Nucleic Acid EC50 770.0 nM 10.1016/j.bmcl.2004.08.016
None Unchecked Activity 75.0 % 10.1074/jbc.m703586200
None Unchecked Activity nan None 10.1016/j.bmc.2014.06.029
None Unchecked Activity nan None 10.1021/acs.jnatprod.6b00037
None Unchecked Activity nan None 10.1074/jbc.m609885200
None Unchecked Activity nan None 10.1074/jbc.m703586200
None Unchecked EC1000 0.02 umol/L 10.1016/j.bmcl.2012.03.004
None Unchecked EC1000 0.19 uM 10.1016/j.bmcl.2004.03.018
None Unchecked EC1000 20.0 nM 10.1016/j.bmc.2014.06.029
None Unchecked EC1000 190.0 nM 10.1016/j.bmc.2007.08.041
None Unchecked EC50 380.0 nM 10.1016/j.bmcl.2014.12.030
None Unchecked EC50 8600.0 nM 10.1021/jm034167p
None Unchecked FC 2.0 None 10.1074/jbc.m703586200
None Unchecked FC 15.0 None 10.1021/ml200136e
None Unchecked FC 25.0 None 10.1021/ml200136e
None Unchecked Fold selectivity 2.0 None 10.1021/jm034167p
None Unchecked IC50 0.4 nM 10.1016/j.ejmech.2018.08.002
None Unchecked IC50 0.4 nM 10.1021/jm034167p
None Unchecked IC50 0.4 nM 10.1021/jm049002a
None Unchecked IC50 0.8 nM 10.1016/j.ejmech.2007.05.004
None Unchecked IC50 0.8 nM 10.1016/j.ejmech.2018.08.002
None Unchecked IC50 0.8 nM 10.1021/jm034167p
None Unchecked IC50 0.8 nM 10.1021/jm049002a
None Unchecked IC50 0.8 nM 10.1021/jm0605536
None Unchecked IC50 1.0 nM 10.1016/j.bmcl.2009.04.102
None Unchecked IC50 3.3 nM 10.1016/s0960-894x(02)00175-0
None Unchecked IC50 3.5 nM 10.1021/jm7011408
None Unchecked IC50 7.0 nM 10.1016/j.ejmech.2018.08.002
None Unchecked IC50 9.1 nM 10.1016/j.bmcl.2016.09.011
None Unchecked IC50 17.0 nM 10.1016/j.bmcl.2009.04.102
None Unchecked IC50 38.0 nM 10.1021/jm034167p
None Unchecked IC50 100.0 nM 10.1038/nchembio.275
None Unchecked IC50 2180.0 nM 10.1016/j.bmcl.2020.126952
None Unchecked IC50 28000.0 nM 10.1021/jm800936s
None Unchecked IC50 3000000.0 nM 10.1016/j.bmcl.2010.11.006
None Unchecked IFI 22.64 % 10.1073/pnas.0802982105
None Unchecked Inhibition 50.0 % 10.1021/acs.jmedchem.6b01595
None Unchecked Inhibition 78.1 % 10.1016/j.ejmech.2014.05.050
None Unchecked Inhibition 93.3 % 10.1016/j.ejmech.2014.05.050
None Unchecked Inhibition nan % 10.1016/j.bmcl.2010.12.079
None Unchecked Inhibition nan % 10.1016/j.bmcl.2016.03.010
None Unchecked Inhibition nan % 10.1016/j.ejmech.2014.05.050
None Unchecked Inhibition nan % 10.1021/jm2016182
None Unchecked Inhibition nan % 10.1021/jm400564j
None Unchecked Ki 6100.0 nM 10.1016/j.bmcl.2020.126952
None Unchecked Potency 35.5 nM None
None Unchecked Potency 141.3 nM None
None Unchecked Potency 200.0 nM None
None Unchecked Potency 794.3 nM None
None Unchecked Potency 1120.0 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Ratio 1.4 None 10.1021/jm0303094
None Unchecked Ratio 2.5 None 10.1016/j.bmc.2023.117300
None Unchecked Ratio IC50 0.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 0.2 None 10.1016/j.bmcl.2010.09.100
None Unchecked Ratio IC50 0.26 None 10.1021/jm7009217
None Unchecked Ratio IC50 0.39 None 10.1016/j.bmc.2019.06.036
None Unchecked Ratio IC50 0.42 None 10.1021/jm7009217
None Unchecked Ratio IC50 0.65 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 0.8 None 10.1021/jm701606b
None Unchecked Ratio IC50 0.98 None 10.1016/j.bmcl.2016.09.011
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmc.2007.08.041
None Unchecked Ratio IC50 1.0 None 10.1016/j.bmcl.2008.12.045
None Unchecked Ratio IC50 1.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 1.5 None 10.1016/j.ejmech.2019.111950
None Unchecked Ratio IC50 2.0 None 10.1016/j.ejmech.2007.05.004
None Unchecked Ratio IC50 2.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 2.0 None 10.1016/j.ejmech.2018.11.020
None Unchecked Ratio IC50 2.2 None 10.1016/j.bmc.2009.10.042
None Unchecked Ratio IC50 2.4 None 10.1016/j.bmcl.2016.09.011
None Unchecked Ratio IC50 2.6 None 10.1016/j.bmc.2009.10.042
None Unchecked Ratio IC50 2.6 None 10.1016/j.bmc.2021.116085
None Unchecked Ratio IC50 2.65 None 10.1016/j.ejmech.2018.03.006
None Unchecked Ratio IC50 2.7 None 10.1016/j.ejmech.2020.112086
None Unchecked Ratio IC50 3.0 None 10.1016/j.bmc.2014.06.029
None Unchecked Ratio IC50 3.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 3.0 None 10.1016/j.ejmech.2019.111755
None Unchecked Ratio IC50 3.06 None 10.1016/j.bmc.2013.06.009
None Unchecked Ratio IC50 3.3 None 10.1021/acsmedchemlett.7b00012
None Unchecked Ratio IC50 3.4 None 10.1021/acs.jmedchem.8b00151
None Unchecked Ratio IC50 4.0 None 10.1016/j.ejmech.2018.03.006
None Unchecked Ratio IC50 4.0 None 10.1016/j.ejmech.2020.112086
None Unchecked Ratio IC50 4.0 None 10.1021/jm301098e
None Unchecked Ratio IC50 4.0 None 10.1021/jm701606b
None Unchecked Ratio IC50 4.4 None 10.1021/acs.jmedchem.9b00946
None Unchecked Ratio IC50 4.5 None 10.1016/j.bmc.2021.116454
None Unchecked Ratio IC50 5.0 None 10.1016/j.bmc.2019.115250
None Unchecked Ratio IC50 5.0 None 10.1016/j.ejmech.2018.11.020
None Unchecked Ratio IC50 6.0 None 10.1021/jm400564j
None Unchecked Ratio IC50 7.14 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 9.9 None 10.1021/acs.jmedchem.8b00151
None Unchecked Ratio IC50 11.0 None 10.1021/acs.jmedchem.0c02210
None Unchecked Ratio IC50 13.14 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 13.4 None 10.1021/acs.jmedchem.8b00151
None Unchecked Ratio IC50 13.6 None 10.1016/j.bmc.2021.116454
None Unchecked Ratio IC50 15.04 None 10.1021/acs.jmedchem.8b00151
None Unchecked Ratio IC50 18.0 None 10.1016/j.ejmech.2014.05.050
None Unchecked Ratio IC50 18.0 None 10.1016/j.ejmech.2018.09.018
None Unchecked Ratio IC50 18.0 None 10.1128/aac.00757-07
None Unchecked Ratio IC50 25.0 None 10.1128/aac.00757-07
None Unchecked Ratio IC50 28.0 None 10.1016/j.ejmech.2021.113569
None Unchecked Ratio IC50 39.0 None 10.1016/j.bmcl.2008.12.045
None Unchecked Ratio IC50 53.12 None 10.1016/j.bmc.2013.06.009
None Unchecked Ratio IC50 120.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 143.0 None 10.1021/jm400564j
None Unchecked Ratio IC50 162.2 None 10.1021/acs.jmedchem.8b00151
None Unchecked Ratio IC50 167.0 None 10.1016/j.ejmech.2018.11.020
None Unchecked Ratio IC50 181.0 None 10.1016/j.bmc.2019.115250
None Unchecked Ratio IC50 209.0 None 10.1016/j.ejmech.2019.111950
None Unchecked Ratio IC50 228.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 303.0 None 10.1016/j.ejmech.2016.12.032
None Unchecked Ratio IC50 315.0 None 10.1016/j.ejmech.2020.112086
None Unchecked Ratio IC50 330.3 None 10.1016/j.bmc.2021.116454
None Unchecked Ratio IC50 392.0 None 10.1016/j.ejmech.2018.03.006
None Unchecked Selectivity 6.7 None 10.1021/jm030222i
None Unchecked Selectivity Index 0.39 None 10.1016/j.bmc.2023.117154
None Unchecked Selectivity ratio 0.26 None 10.1021/jm060554y
None Unchecked Selectivity ratio 0.42 None 10.1021/jm060554y
None Unchecked Selectivity ratio 1.52 None 10.1016/j.ejmech.2021.113338
None Unchecked Selectivity ratio 8.27 None 10.1016/j.ejmech.2021.113338
None Unchecked Selectivity ratio 69.3 None 10.1016/j.ejmech.2021.113338
None Unchecked SI 2.0 None 10.1021/jm049002a

Metabolism Information