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Trimethoprim

AlkaPlorer ID: AK011942

Synonym: None

IUPAC Name: 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Structure

SMILES: COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC

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InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

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InChIKey: IEDVJHCEMCRBQM-UHFFFAOYSA-N

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Reference

PubChem CID: 5578

CAS: 738-70-5

SuperNatural Ⅲ: SN0143223

NPASS: NPC339651

COCONUT: CNP0117617

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 290.32300000000004

TPSA？: 105.51

MolLogP？: 1.2575999999999998

Number of H-Donors: 2

Number of H-Acceptors: 7

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c01169
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Acinetobacter baumannii Acinetobacter baumannii MIC 8.0 ug.mL-1 10.1039/d2md00260d
Acinetobacter baumannii Acinetobacter baumannii MIC 16.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Acinetobacter baumannii Acinetobacter baumannii MIC 32.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Acinetobacter baumannii Acinetobacter baumannii MIC 64.0 ug.mL-1 10.1128/aac.00748-09
Acinetobacter baumannii Acinetobacter baumannii MIC 128.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Acinetobacter baumannii Acinetobacter baumannii MIC 512.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Acinetobacter baumannii Acinetobacter baumannii MIC 6250.0 nM 10.1016/j.bmcl.2022.129086
Acinetobacter baumannii Acinetobacter baumannii MIC 10000.0 nM 10.6019/CHEMBL4513141
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Acinetobacter baumannii Acinetobacter baumannii MIC 400000.0 nM 10.1016/j.bmcl.2022.129086
Acinetobacter baumannii Acinetobacter baumannii Ratio 1.0 None 10.1128/aac.00748-09
Acinetobacter calcoaceticus Acinetobacter calcoaceticus Activity 16.0 ug ml-1 10.1128/aac.00652-07
Acinetobacter lwoffii Acinetobacter lwoffii Activity 16.0 ug ml-1 10.1128/aac.00652-07
Aeromonas caviae Aeromonas caviae Activity 14.9 % 10.1128/aac.01260-08
Aeromonas caviae Aeromonas caviae Activity 85.1 % 10.1128/aac.01260-08
Aeromonas caviae Aeromonas caviae MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Aeromonas caviae Aeromonas caviae MIC90 8.0 ug.mL-1 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila Activity 14.9 % 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila Activity 85.1 % 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Aeromonas hydrophila Aeromonas hydrophila MIC90 8.0 ug.mL-1 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria Activity 14.9 % 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria Activity 85.1 % 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Aeromonas sobria Aeromonas sobria MIC90 8.0 ug.mL-1 10.1128/aac.01260-08
Babesia gibsoni Babesia gibsoni Activity nan None 10.1128/aac.00384-08
Bacillus anthracis Anthrax lethal factor Potency 12589.3 nM None
Bacillus anthracis Bacillus anthracis MIC 256.0 ug.mL-1 10.1128/aac.00361-10
Bacillus anthracis Bacillus anthracis MIC 2048.0 ug.mL-1 10.1016/j.bmc.2014.11.009
Bacillus anthracis Bacillus anthracis MIC 2048.0 ug.mL-1 10.1128/aac.00628-07
Bacillus anthracis Dihydrofolate reductase IC50 3780.0 nM 10.1021/jm100727t
Bacillus anthracis Dihydrofolate reductase IC50 5760.0 nM 10.1021/jm100727t
Bacillus anthracis Dihydrofolate reductase IC50 71000.0 nM 10.1021/jm800776a
Bacillus anthracis Dihydrofolate reductase IC50 71400.0 nM 10.1021/jm100727t
Bacillus anthracis Dihydrofolate reductase IC50 77000.0 nM 10.1128/aac.01666-08
Bacillus anthracis Dihydrofolate reductase Ki 480.0 nM 10.1021/jm100727t
Bacillus anthracis Dihydrofolate reductase Ki 13700.0 nM 10.1021/jm100727t
Bacillus anthracis Dihydrofolate reductase Ki 24100.0 nM 10.1021/jm100727t
Bacillus anthracis Dihydropteroate synthase IC50 nan None 10.1016/j.bmcl.2016.07.006
Bacillus cereus Bacillus cereus IZ 0.0 mm 10.1007/s00044-012-0104-0
Bacillus cereus Bacillus cereus MIC 0.0 ug.mL-1 10.1007/s00044-012-0104-0
Bacillus spizizenii Bacillus spizizenii MIC90 nan None 10.1016/j.ejmech.2017.12.089
Bacillus subtilis Bacillus subtilis IC50 300.0 nM 10.1021/acs.jnatprod.0c00125
Bacillus subtilis Bacillus subtilis IZ 20.0 mm 10.1007/s00044-012-0104-0
Bacillus subtilis Bacillus subtilis MIC 0.25 ug.mL-1 10.1021/acs.jnatprod.9b01185
Bacillus subtilis Bacillus subtilis MIC 1.0 ug.mL-1 10.1007/s00044-012-0104-0
Bacillus subtilis (strain 168) NH(3)-dependent NAD(+) synthetase IC50 1000.0 nM 10.1021/jm030003x
Bacteria Bacterial dihydrofolate reductase IC50 450.0 nM 10.1021/jm00128a040
Bacteria Bacterial dihydrofolate reductase IC50 12000.0 nM 10.1021/jm010407u
Bacteroides fragilis Bacteroides fragilis MIC 3.1 ug.mL-1 10.1021/jm00128a043
Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC 12.5 ug.mL-1 10.1021/jm00128a043
Bos taurus Dihydrofolate reductase IC50 0.042 ug.mL-1 10.1016/j.bmc.2017.10.041
Bos taurus Dihydrofolate reductase IC50 0.042 ug.mL-1 10.1016/j.bmc.2019.06.038
Bos taurus Dihydrofolate reductase IC50 0.042 ug.mL-1 10.1016/j.ejmech.2017.02.012
Bos taurus Dihydrofolate reductase IC50 6309573.44 nM 10.1021/jm00163a067
Bos taurus Dihydrofolate reductase Log 1/C 5.1 None 10.1021/jm00139a010
Bos taurus Dihydrofolate reductase Log 1/C 5.1 None 10.1021/jm00185a011
Bos taurus Dihydrofolate reductase Log 1/C 5.1 None 10.1021/jm00361a011
Bos taurus Dihydrofolate reductase log(1/I50) 5.1 None 10.1021/jm00192a003
Bos taurus Dihydrofolate reductase Log 1/Ki app 5.51 None 10.1021/jm00137a012
Bos taurus Dihydrofolate reductase Log 1/Ki app 5.51 None 10.1021/jm00346a020
Brucella abortus Brucella abortus MIC 32.0 ug.mL-1 10.1128/aac.00361-10
Campylobacter coli Campylobacter coli MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Campylobacter coli Campylobacter coli MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Campylobacter coli Campylobacter coli MIC90 8.0 ug.mL-1 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni MIC50 2.0 ug.mL-1 10.1128/aac.01260-08
Campylobacter jejuni Campylobacter jejuni MIC90 8.0 ug.mL-1 10.1128/aac.01260-08
Candida albicans Candida albicans IZ 0.0 mm 10.1007/s00044-012-0104-0
Candida albicans Candida albicans IZ 0.0 mm 10.1016/j.ejmech.2020.112969
Candida albicans Candida albicans MIC 0.0 ug.mL-1 10.1007/s00044-012-0104-0
Candida albicans Candida albicans MIC 12.5 ug.mL-1 10.1007/s00044-011-9605-5
Candida albicans Candida albicans MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Candida albicans Candida albicans MIC 50.0 ug.mL-1 10.1021/jm00018a021
Candida albicans Candida albicans MIC 10000.0 nM 10.6019/CHEMBL4513141
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Candida albicans Dihydrofolate reductase IC50 2.2 nM 10.1021/jm030931w
Candida albicans Dihydrofolate reductase IC50 270.0 nM 10.1021/jm030931w
Candida albicans Dihydrofolate reductase IC50 30300.0 nM 10.1021/jm030931w
Candida albicans Dihydrofolate reductase IC50 41000.0 nM 10.1039/C3MD00104K
Candida albicans Dihydrofolate reductase IC50 42000.0 nM 10.1016/j.bmc.2009.06.021
Candida albicans Dihydrofolate reductase IC50 50000.0 nM 10.1021/jm00018a021
Candida parapsilosis Candida parapsilosis MIC 12.5 ug.mL-1 10.1007/s00044-011-9605-5
Candida tropicalis Candida tropicalis MIC 25.0 ug.mL-1 10.1007/s00044-011-9605-5
[Candida] zeylanoides [Candida] zeylanoides MIC 25.0 ug.mL-1 10.1007/s00044-011-9605-5
Canis lupus familiaris Canis familiaris T1/2 3.44 hr 10.1021/jm00128a043
Canis lupus familiaris MDCK CC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Canis lupus familiaris MDCK logPapp -4.56 None 10.1021/jm901846t
Canis lupus familiaris MDCK MCC 100000.0 nM 10.1016/j.ejmech.2017.04.070
Chlorocebus sabaeus Vero IC50 50000.0 nM 10.1021/jm010131q
Chlorocebus sabaeus Vero IC50 nan None 10.1016/j.bmc.2017.10.041
Chlorocebus sabaeus Vero IC50 nan None 10.1016/j.bmc.2019.06.038
Chlorocebus sabaeus Vero MCC 100000.0 nM 10.1016/j.ejmech.2017.04.070
Citrobacter freundii Citrobacter freundii MIC 256.0 ug.mL-1 10.1128/aac.00886-08
Clostridioides difficile Clostridioides difficile MIC 25.0 ug.mL-1 10.1021/jm00128a043
Clostridium perfringens Clostridium perfringens MIC 25.0 ug.mL-1 10.1021/jm00128a043
Corynebacterium sp. Corynebacterium sp. Activity nan None 10.1128/aac.00845-09
Corynebacterium sp. Corynebacterium sp. MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Corynebacterium sp. Corynebacterium sp. MIC50 16.0 ug.mL-1 10.1128/aac.00845-09
Corynebacterium sp. Corynebacterium sp. MIC90 16.0 ug.mL-1 10.1128/aac.00845-09
Coxsackievirus B4 Coxsackievirus B4 EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Cryptococcus neoformans Cryptococcus neoformans MIC 10000.0 nM 10.6019/CHEMBL4513141
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase IC50 4000.0 nM 10.1007/s00044-008-9097-0
Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase IC50 14000.0 nM 10.1016/j.bmcl.2006.05.047
Cryptosporidium parvum Cryptosporidium parvum IC50 4000.0 nM 10.1016/j.bmc.2010.01.068
Cyberlindnera jadinii Cyberlindnera jadinii MIC 25.0 ug.mL-1 10.1007/s00044-011-9605-5
Edwardsiella ictaluri Edwardsiella ictaluri MIC 1.0 ug.mL-1 10.1128/aac.01312-08
Enterobacter cloacae Enterobacter cloacae Activity 89.0 % 10.1128/aac.00675-09
Enterobacter cloacae Enterobacter cloacae Activity 100.0 % 10.1128/aac.00675-09
Enterococcus faecalis Enterococcus faecalis Activity nan None 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 0.6 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 4.2 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 29.7 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 56.5 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 62.9 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 64.5 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 67.7 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 70.0 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 70.6 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 71.0 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 72.9 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis Inhibition 100.0 % 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis IZ 27.0 mm 10.1007/s00044-012-0104-0
Enterococcus faecalis Enterococcus faecalis MIC 0.03 ug.mL-1 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1021/jm00134a003
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1021/jm00196a019
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1021/jm00205a009
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1021/jm00208a010
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1039/d2md00260d
Enterococcus faecalis Enterococcus faecalis MIC 0.25 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecalis Enterococcus faecalis MIC 0.5 ug.mL-1 10.1007/s00044-012-0104-0
Enterococcus faecalis Enterococcus faecalis MIC 0.5 ug.mL-1 10.1016/j.bmcl.2011.07.059
Enterococcus faecalis Enterococcus faecalis MIC 1.0 ug.mL-1 10.1128/aac.00361-10
Enterococcus faecalis Enterococcus faecalis MIC 16.0 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecalis Enterococcus faecalis MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Enterococcus faecalis Enterococcus faecalis MIC 64.0 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecalis Enterococcus faecalis MIC 128.0 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecalis Enterococcus faecalis MIC50 0.25 ug.mL-1 10.1128/aac.00129-09
Enterococcus faecalis Enterococcus faecalis MIC90 64.0 ug.mL-1 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Activity nan None 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium IC50 80.0 nM 10.1021/jm00212a010
Enterococcus faecium Enterococcus faecium IC50 1200.0 nM 10.1021/jm00212a010
Enterococcus faecium Enterococcus faecium Inhibition 13.9 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 30.4 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 36.0 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 37.3 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 37.6 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 38.0 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 38.3 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 38.9 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 41.6 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 47.2 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 55.1 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 60.7 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition 100.0 % 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Inhibition nan % 10.1021/jm00212a010
Enterococcus faecium Enterococcus faecium MIC 0.03 ug.mL-1 10.1039/d2md00260d
Enterococcus faecium Enterococcus faecium MIC 0.03 ug.mL-1 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium MIC 0.25 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecium Enterococcus faecium MIC 0.5 ug.mL-1 10.1016/j.ejmech.2021.113979
Enterococcus faecium Enterococcus faecium MIC 0.5 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecium Enterococcus faecium MIC 128.0 ug.mL-1 10.1128/aac.00377-09
Enterococcus faecium Enterococcus faecium MIC 780.0 nM 10.1016/j.bmcl.2022.129086
Enterococcus faecium Enterococcus faecium MIC 100000.0 nM 10.1016/j.bmcl.2022.129086
Enterococcus faecium Enterococcus faecium MIC50 32.0 ug.mL-1 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium MIC90 64.0 ug.mL-1 10.1128/aac.00129-09
Enterococcus faecium Enterococcus faecium Ratio IC50 15.0 None 10.1021/jm00212a010
Enterococcus sp. Enterococcus sp. MIC90 8.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Escherichia coli Dihydrofolate reductase Activity 0.5 10'-8M 10.1021/jm00211a020
Escherichia coli Dihydrofolate reductase Activity 8.08 None 10.1021/jm000226c
Escherichia coli Dihydrofolate reductase Activity 8.08 None 10.1021/jm00095a016
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00108a022
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00128a041
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00128a043
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00140a005
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00178a007
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00179a012
Escherichia coli Dihydrofolate reductase IC50 5.0 nM 10.1021/jm00394a012
Escherichia coli Dihydrofolate reductase IC50 5.888 nM 10.1021/jm960491r
Escherichia coli Dihydrofolate reductase IC50 6.0 nM 10.1021/jm00128a043
Escherichia coli Dihydrofolate reductase IC50 7.0 nM 10.1016/j.bmcl.2003.07.023
Escherichia coli Dihydrofolate reductase IC50 7.0 nM 10.1021/jm00106a011
Escherichia coli Dihydrofolate reductase IC50 7.0 nM 10.1021/jm00385a017
Escherichia coli Dihydrofolate reductase IC50 10.0 nM 10.1016/j.bmc.2012.05.068
Escherichia coli Dihydrofolate reductase IC50 10.0 nM 10.1021/jm8006933
Escherichia coli Dihydrofolate reductase IC50 10.0 nM 10.1021/jm900490a
Escherichia coli Dihydrofolate reductase IC50 15.0 nM 10.1021/jm0203534
Escherichia coli Dihydrofolate reductase IC50 18.0 nM 10.1016/s0960-894x(03)00480-3
Escherichia coli Dihydrofolate reductase IC50 18.0 nM 10.1021/jm980081y
Escherichia coli Dihydrofolate reductase IC50 20.0 nM 10.1021/jm0202369
Escherichia coli Dihydrofolate reductase IC50 20.0 nM 10.1021/jm800244v
Escherichia coli Dihydrofolate reductase IC50 20.0 nM 10.1021/jm9011142
Escherichia coli Dihydrofolate reductase IC50 37.0 nM 10.1016/s0960-894x(03)00480-3
Escherichia coli Dihydrofolate reductase IC50 1000.0 nM 10.1021/jm0100382
Escherichia coli Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm030312n
Escherichia coli Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm030312n
Escherichia coli Dihydrofolate reductase IC50 10000000.0 nM 10.1021/jm00163a067
Escherichia coli Dihydrofolate reductase Inhibition nan % 10.1038/nchembio.108
Escherichia coli Dihydrofolate reductase Inhibition nan % 10.1038/nchembio.221
Escherichia coli Dihydrofolate reductase Kd 1.0 None 10.1021/jm00381a008
Escherichia coli Dihydrofolate reductase Ki 0.22 nM 10.1021/acsmedchemlett.6b00120
Escherichia coli Dihydrofolate reductase Ki 1.3 nM 10.1021/jm00128a042
Escherichia coli Dihydrofolate reductase Ki 1.3 nM 10.1021/jm00128a043
Escherichia coli Dihydrofolate reductase Ki 1.3 nM 10.1021/jm00352a002
Escherichia coli Dihydrofolate reductase Ki 1.3 nM 10.1021/jm00381a008
Escherichia coli Dihydrofolate reductase Ki 1.349 nM 10.1021/jm00402a025
Escherichia coli Dihydrofolate reductase Ki 3.8 nM 10.1016/s0960-894x(03)00480-3
Escherichia coli Dihydrofolate reductase Log 1/C 8.87 None 10.1021/jm00185a011
Escherichia coli Dihydrofolate reductase log(1/I50) 8.3 None 10.1021/jm00211a020
Escherichia coli Dihydrofolate reductase Log 1/Ki app 8.87 None 10.1021/jm00137a012
Escherichia coli Dihydrofolate reductase Log 1/Ki app 8.87 None 10.1021/jm00349a003
Escherichia coli Dihydrofolate reductase Log 1/Ki app 8.87 None 10.1021/jm00397a017
Escherichia coli Dihydrofolate reductase Ratio 1.0 None 10.1021/jm00140a005
Escherichia coli Dihydrofolate reductase Ratio 2.1 None 10.1016/s0960-894x(03)00480-3
Escherichia coli Dihydrofolate reductase type 1 C50 0.55 M 10.1021/jm00139a010
Escherichia coli Dihydrofolate reductase type 1 IC50 5e-08 nM 10.1021/jm00128a042
Escherichia coli Dihydrofolate reductase type 1 IC50 500.0 nM 10.1021/jm00128a040
Escherichia coli Dihydrofolate reductase type 1 Log 1/C 8.87 None 10.1021/jm00381a013
Escherichia coli Escherichia coli Activity 2.6 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 4.3 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 13.1 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 18.2 % 10.1128/aac.00551-10
Escherichia coli Escherichia coli Activity 25.0 % 10.1128/aac.01260-08
Escherichia coli Escherichia coli Activity 46.9 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 49.1 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 50.2 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 56.3 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 61.7 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 75.0 % 10.1128/aac.01260-08
Escherichia coli Escherichia coli Activity 95.0 % 10.1128/aac.00675-09
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.00375-07
Escherichia coli Escherichia coli Activity 100.0 % 10.1128/aac.00675-09
Escherichia coli Escherichia coli Activity 1000.0 CFU/ml 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli Activity nan None 10.1016/j.bmcl.2013.02.005
Escherichia coli Escherichia coli Activity nan None 10.1021/jm00205a009
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00375-07
Escherichia coli Escherichia coli ED50 1.4 mg mouse-1 10.1021/jm00140a005
Escherichia coli Escherichia coli ED50 1.8 mg mouse-1 10.1021/jm00140a005
Escherichia coli Escherichia coli ED50 1.9 mg mouse-1 10.1021/jm00140a005
Escherichia coli Escherichia coli FC 512.0 None 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli IC50 400.0 nM 10.1021/jm00212a010
Escherichia coli Escherichia coli Inhibition nan % 10.1021/jm00212a010
Escherichia coli Escherichia coli IZ 0.0 mm 10.1007/s00044-012-0104-0
Escherichia coli Escherichia coli IZ 24.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 26.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 30.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 31.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 32.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 33.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 36.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 38.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 40.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 42.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli IZ 44.0 mM 10.1128/aac.00052-07
Escherichia coli Escherichia coli Log 1/C 5.22 None 10.1021/jm00397a017
Escherichia coli Escherichia coli Log 1/C 5.34 None 10.1021/jm00150a026
Escherichia coli Escherichia coli Log 1/C 6.61 None 10.1021/jm00150a026
Escherichia coli Escherichia coli Log 1/C 7.06 None 10.1021/jm00397a017
Escherichia coli Escherichia coli Log 1/MIC 3.1 None 10.1021/jm00163a067
Escherichia coli Escherichia coli MBC 1.0 ug ml-1 10.1128/aac.00052-07
Escherichia coli Escherichia coli MBC 4.0 ug ml-1 10.1128/aac.00052-07
Escherichia coli Escherichia coli MBC 8.0 ug ml-1 10.1128/aac.00052-07
Escherichia coli Escherichia coli MBC 100.0 ug ml-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 0.0 ug.mL-1 10.1007/s00044-012-0104-0
Escherichia coli Escherichia coli MIC 0.0098 ug.mL-1 10.1021/acsmedchemlett.6b00120
Escherichia coli Escherichia coli MIC 0.02 ug.mL-1 10.1128/aac.00580-10
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 0.03 ug.mL-1 10.1128/aac.01094-07
Escherichia coli Escherichia coli MIC 0.05 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00111-10
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 0.06 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1016/j.bmcl.2009.10.057
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1021/jm00394a012
Escherichia coli Escherichia coli MIC 0.1 ug.mL-1 10.1128/aac.01312-08
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00111-10
Escherichia coli Escherichia coli MIC 0.12 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1016/j.bmcl.2012.02.019
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.00748-09
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01381-07
Escherichia coli Escherichia coli MIC 0.125 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 0.16 ug.mL-1 10.1128/aac.00580-10
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1128/aac.00748-09
Escherichia coli Escherichia coli MIC 0.2 ug.mL-1 10.1128/aac.01052-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1021/jm00196a019
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1021/jm00208a010
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00052-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.00886-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01400-08
Escherichia coli Escherichia coli MIC 0.25 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 0.3 ug.mL-1 10.1021/jm00178a007
Escherichia coli Escherichia coli MIC 0.3125 ug.mL-1 10.1021/acsmedchemlett.6b00120
Escherichia coli Escherichia coli MIC 0.35 ug.mL-1 10.1021/acs.jmedchem.7b00204
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00052-07
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00310-09
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00886-08
Escherichia coli Escherichia coli MIC 0.5 ug.mL-1 10.1128/aac.00944-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.bmcl.2011.07.059
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/acs.jmedchem.9b01210
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jm00128a043
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1021/jm00396a018
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.00310-09
Escherichia coli Escherichia coli MIC 1.0 ug.mL-1 10.1128/aac.01312-08
Escherichia coli Escherichia coli MIC 1.0 None 10.1021/jm00381a008
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00052-07
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1128/aac.00944-09
Escherichia coli Escherichia coli MIC 8.2 ug.mL-1 10.1128/aac.00580-10
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1039/d2md00260d
Escherichia coli Escherichia coli MIC 25.0 ug.mL-1 10.1021/jm00134a003
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00375-07
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.00688-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01045-09
Escherichia coli Escherichia coli MIC 32.0 ug.mL-1 10.1128/aac.01273-06
Escherichia coli Escherichia coli MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.02.019
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli MIC 64.0 ug.mL-1 10.1128/aac.01412-06
Escherichia coli Escherichia coli MIC 125.0 ug.mL-1 10.1016/j.ejmech.2019.111744
Escherichia coli Escherichia coli MIC 128.0 ug.mL-1 10.1128/aac.01400-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00638-08
Escherichia coli Escherichia coli MIC 256.0 ug.mL-1 10.1128/aac.00886-08
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.00616-07
Escherichia coli Escherichia coli MIC 512.0 ug.mL-1 10.1128/aac.01128-08
Escherichia coli Escherichia coli MIC 700.0 nM 10.1016/j.bmcl.2016.07.006
Escherichia coli Escherichia coli MIC 1250.0 nM 10.6019/CHEMBL4513141
Escherichia coli Escherichia coli MIC 1300.0 nM 10.1021/acs.jmedchem.1c01962
Escherichia coli Escherichia coli MIC 1400.0 nM 10.1016/j.bmcl.2016.07.006
Escherichia coli Escherichia coli MIC 1700.0 nM 10.1016/j.bmcl.2016.07.006
Escherichia coli Escherichia coli MIC 2500.0 nM 10.6019/CHEMBL4513161
Escherichia coli Escherichia coli MIC 55100.0 nM 10.1016/j.bmcl.2016.10.051
Escherichia coli Escherichia coli MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Escherichia coli Escherichia coli MIC90 64.0 ug.mL-1 10.1128/aac.01260-08
Escherichia coli Escherichia coli MIC90 55100.0 nM 10.1016/j.ejmech.2017.12.089
Escherichia coli Escherichia coli Ratio 2.0 None 10.1128/aac.00748-09
Escherichia coli Escherichia coli Ratio 2048.0 None 10.1128/aac.01128-08
Escherichia coli Thymidylate synthase IC50 nan None 10.1021/jm701052u
Escherichia coli Thymidylate synthase IC50 nan None 10.1021/jm8006933
Escherichia coli Thymidylate synthase IC50 nan None 10.1021/jm900490a
Escherichia coli K-12 Beta-lactamase AmpC Inhibition 5.0 % 10.1021/jm030191r
Escherichia coli K-12 Endonuclease 4 Potency 891.3 nM None
Escherichia coli K-12 Thymidylate synthase Activity nan None 10.1016/j.ejmech.2021.113979
Escherichia coli (strain K12) 30S ribosomal protein S18 Inhibition nan % 10.1038/nchembio.221
Escherichia coli (strain K12) Bifunctional protein FolC Inhibition nan % 10.1038/nchembio.108
Fusobacterium nucleatum Fusobacterium nucleatum MIC 0.8 ug.mL-1 10.1021/jm00128a043
Gallus gallus Dihydrofolate reductase IC50 0.0076 nM 10.1021/jm00128a042
Gallus gallus Dihydrofolate reductase IC50 730000.0 nM 10.1021/jm00394a012
Gallus gallus Dihydrofolate reductase IC50 750000.0 nM 10.1021/jm00381a008
Gallus gallus Dihydrofolate reductase Ki 104712.85 nM 10.1021/jm00105a008
Gallus gallus Dihydrofolate reductase Ki 104712.85 nM 10.1021/jm00128a035
Gallus gallus Dihydrofolate reductase Log 1/C 3.98 None 10.1021/jm00155a006
Gallus gallus Dihydrofolate reductase Log 1/C 3.98 None 10.1021/jm970776j
Gallus gallus Dihydrofolate reductase Log 1/Ki app 3.98 None 10.1021/jm00346a020
Haemophilus influenzae Haemophilus influenzae MIC 0.5 ug.mL-1 10.1016/j.bmcl.2011.07.059
Haemophilus influenzae Haemophilus influenzae MIC 4.0 ug.mL-1 10.1128/aac.00377-09
Haemophilus influenzae Haemophilus influenzae MIC 128.0 ug.mL-1 10.1128/aac.00377-09
Haemophilus influenzae Haemophilus influenzae MIC nan None 10.1128/aac.00377-09
Haemophilus influenzae Haemophilus influenzae MIC90 1.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Homo sapiens 786-0 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens A498 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens A549 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens ACHN TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Adenosine A1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 29081.0 nM None
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 833100.0 nM 10.1124/dmd.112.047068
Homo sapiens Bloom syndrome protein Potency 3.2 nM None
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Caco-2 logPapp -4.06 None 10.1016/j.bmc.2011.03.011
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity 107.0 % 10.1021/jm7015683
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens CCRF-CEM TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin B receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Chromobox protein homolog 1 Potency 6.0 nM None
Homo sapiens Chymotrypsin C Inhibition 5.0 % 10.1021/jm030191r
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2C19 Potency 39810.7 nM None
Homo sapiens Cytochrome P450 2C8 Activity nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 2J2 IC50 50000.0 nM 10.1124/dmd.112.048264
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition nan % 10.1021/tx300075j
Homo sapiens Cytochrome P450 3A4 Potency 12589.3 nM None
Homo sapiens Cytochrome P450 3A4 Ratio IC50 2.0 None 10.1021/tx300075j
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dihydrofolate reductase Activity 74.0 % 10.1128/aac.00377-09
Homo sapiens Dihydrofolate reductase Activity 30000.0 10'-8M 10.1021/jm00211a020
Homo sapiens Dihydrofolate reductase IC50 54.0 nM 10.1021/jm980081y
Homo sapiens Dihydrofolate reductase IC50 75.0 nM 10.1016/j.bmcl.2003.07.023
Homo sapiens Dihydrofolate reductase IC50 75.0 nM 10.1021/jm020495y
Homo sapiens Dihydrofolate reductase IC50 123.0 nM 10.1016/j.bmcl.2012.02.019
Homo sapiens Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00128a041
Homo sapiens Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00128a043
Homo sapiens Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00394a012
Homo sapiens Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00396a018
Homo sapiens Dihydrofolate reductase IC50 900.0 nM 10.1021/jm030599o
Homo sapiens Dihydrofolate reductase IC50 1030.0 nM 10.1016/j.ejmech.2020.112986
Homo sapiens Dihydrofolate reductase IC50 2000.0 nM 10.1021/jm030438k
Homo sapiens Dihydrofolate reductase IC50 3000.0 nM 10.1021/jm020495y
Homo sapiens Dihydrofolate reductase IC50 3400.0 nM 10.1021/jm0203534
Homo sapiens Dihydrofolate reductase IC50 5000.0 nM 10.1021/jm030438k
Homo sapiens Dihydrofolate reductase IC50 24500.0 nM 10.1016/j.bmc.2018.04.032
Homo sapiens Dihydrofolate reductase IC50 24500.0 nM 10.1016/j.bmcl.2019.06.004
Homo sapiens Dihydrofolate reductase IC50 32200.0 nM 10.1016/j.bmcl.2019.06.004
Homo sapiens Dihydrofolate reductase IC50 32200.0 nM 10.1021/jm400086g
Homo sapiens Dihydrofolate reductase IC50 34000.0 nM 10.1021/jm020495y
Homo sapiens Dihydrofolate reductase IC50 100000.0 nM 10.1016/j.bmcl.2011.06.125
Homo sapiens Dihydrofolate reductase IC50 120000.0 nM 10.1021/jm800776a
Homo sapiens Dihydrofolate reductase IC50 198000.0 nM 10.1016/j.bmc.2009.06.021
Homo sapiens Dihydrofolate reductase IC50 200000.0 nM 10.1021/jm0100382
Homo sapiens Dihydrofolate reductase IC50 300000.0 nM 10.1016/j.bmcl.2003.07.023
Homo sapiens Dihydrofolate reductase IC50 300000.0 nM 10.1021/jm030438k
Homo sapiens Dihydrofolate reductase IC50 320000.0 nM 10.1021/jm8006933
Homo sapiens Dihydrofolate reductase IC50 340000.0 nM 10.1016/j.bmc.2012.05.068
Homo sapiens Dihydrofolate reductase IC50 340000.0 nM 10.1021/jm0202369
Homo sapiens Dihydrofolate reductase IC50 340000.0 nM 10.1021/jm701052u
Homo sapiens Dihydrofolate reductase IC50 340000.0 nM 10.1021/jm900490a
Homo sapiens Dihydrofolate reductase IC50 490000.0 nM 10.1021/jm00018a021
Homo sapiens Dihydrofolate reductase IC50 503000.0 nM 10.1021/acs.jmedchem.8b01754
Homo sapiens Dihydrofolate reductase IC50 680000.0 nM 10.1016/j.bmcl.2017.02.018
Homo sapiens Dihydrofolate reductase IC50 680000.0 nM 10.1021/jm070165j
Homo sapiens Dihydrofolate reductase IC50 680000.0 nM 10.1021/jm800244v
Homo sapiens Dihydrofolate reductase IC50 680000.0 nM 10.1021/jm9011142
Homo sapiens Dihydrofolate reductase IC50 890000.0 nM 10.1007/s00044-008-9097-0
Homo sapiens Dihydrofolate reductase IC50 900000.0 nM 10.1021/jm020495y
Homo sapiens Dihydrofolate reductase IC50 900000.0 nM 10.1021/jm030599o
Homo sapiens Dihydrofolate reductase Inhibition 22.0 % 10.1021/jm701052u
Homo sapiens Dihydrofolate reductase Inhibition 22.0 % 10.1021/jm8006933
Homo sapiens Dihydrofolate reductase Inhibition 22.0 % 10.1021/jm900490a
Homo sapiens Dihydrofolate reductase IZ 6.0 mm 10.1016/j.bmc.2007.04.011
Homo sapiens Dihydrofolate reductase Ki 0.006 nM 10.1021/jm500325k
Homo sapiens Dihydrofolate reductase Ki 10.0 nM 10.1016/j.ejmech.2020.112986
Homo sapiens Dihydrofolate reductase Ki 10.0 nM 10.1021/jm981130+
Homo sapiens Dihydrofolate reductase Ki 120.0 nM 10.1021/jm981130+
Homo sapiens Dihydrofolate reductase Ki 194.98 nM 10.1021/jm00006a016
Homo sapiens Dihydrofolate reductase Ki 1000.0 nM 10.1021/jm981130+
Homo sapiens Dihydrofolate reductase Ki 1380.0 nM 10.1021/jm981130+
Homo sapiens Dihydrofolate reductase Ki 4900.0 nM 10.1016/j.bmc.2009.08.044
Homo sapiens Dihydrofolate reductase Ki 19070.0 nM 10.1016/j.bmcl.2011.07.059
Homo sapiens Dihydrofolate reductase Ki 19070.0 nM 10.1021/jm401204g
Homo sapiens Dihydrofolate reductase Ki 45783.5 nM 10.1021/acsmedchemlett.6b00120
Homo sapiens Dihydrofolate reductase Ki 48000.0 nM 10.1016/j.ejmech.2017.04.070
Homo sapiens Dihydrofolate reductase MIC 2.0 ug.mL-1 10.1021/jm020495y
Homo sapiens Dihydrofolate reductase MIC 64.0 ug.mL-1 10.1021/jm020495y
Homo sapiens Dihydrofolate reductase NI nan None 10.1021/jm010131q
Homo sapiens Dihydrofolate reductase Ratio 1.0 None 10.1021/jm00140a005
Homo sapiens Dihydrofolate reductase SI 14.0 None 10.1021/jm030438k
Homo sapiens Dihydrofolate reductase SI 65.0 None 10.1021/jm030438k
Homo sapiens Dihydrofolate reductase SI 610.0 None 10.1021/jm030438k
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor Potency 23.1 nM None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens EKVX TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 6.3 nM None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 1584.9 nM None
Homo sapiens Ghrelin receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HEK293 Activity nan None 10.1021/acs.jmedchem.9b01210
Homo sapiens HEK293 CC50 10000.0 nM 10.6019/CHEMBL4513141
Homo sapiens HEK293 CC50 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEK293 Potency 1834.9 nM None
Homo sapiens HeLa MCC 100000.0 nM 10.1016/j.ejmech.2017.04.070
Homo sapiens HepG2 Inhibition 0.0 % 10.1038/nature09107
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 239883.29 nM 10.1016/j.bmc.2008.04.028
Homo sapiens HERG IC50 239883.29 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 239883.29 nM 10.1016/s0960-894x(03)00492-x
Homo sapiens HFF TD50 100.0 uM 10.1016/j.bmcl.2012.12.024
Homo sapiens HFF TD50 320.0 uM 10.1016/j.ejmech.2014.08.046
Homo sapiens HFF TD50 320.0 uM 10.1021/jm9005862
Homo sapiens HFF TD50 320.0 uM 10.1021/jm901857d
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -29.75 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -5.72 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 281.8 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 10000.0 nM None
Homo sapiens Homo sapiens Activity 0.97 % 10.1016/j.ejmech.2009.11.034
Homo sapiens Homo sapiens CL 1.2 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL 2.1 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 2.1 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.9 mL.min-1.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens CL_renal 0.92 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 7922.29 nM 10.1128/aac.00375-07
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 4.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens F 63.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens F 98.0 % 10.1021/jm901846t
Homo sapiens Homo sapiens Fa 0.97 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fabs 97.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens F_fraction 0.76 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fg 0.83 None 10.1021/jm901371v
Homo sapiens Homo sapiens Fh 0.95 None 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 1.5 L.kg-1 10.1021/jm901371v
Homo sapiens Homo sapiens Vdss 1.6 L.kg-1 10.1016/j.ejmech.2009.06.004
Homo sapiens HT-29 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Hydroxycarboxylic acid receptor 2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Interleukin-8 Potency 74978.0 nM None
Homo sapiens K562 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens KB IC50 250000.0 nM 10.1021/jm010131q
Homo sapiens KM12 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Liver microsomes Activity nan None 10.1021/tx300075j
Homo sapiens Liver microsomes Stability nan % 10.1021/tx300075j
Homo sapiens M14 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Malate dehydrogenase cytoplasmic Inhibition 5.0 % 10.1021/jm030191r
Homo sapiens Malme-3M TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens MCF7 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens MDA-MB-231 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens MDA-MB-435 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens MDA-MB-468 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Melanocortin receptor 3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 35481.3 nM None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A Activity nan None 10.1021/jm800656v
Homo sapiens Monoamine oxidase B Activity nan None 10.1021/jm800656v
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens NCI-H226 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens NCI-H23 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens NCI-H322M TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens NCI-H460 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens NCI-H522 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 251.2 nM None
Homo sapiens P-glycoprotein 1 Activity nan None 10.1006/taap.2002.9461
Homo sapiens P-glycoprotein 1 Activity nan None None
Homo sapiens P-glycoprotein 1 % maximum response 1.35 % None
Homo sapiens P-glycoprotein 1 Papp 73.9 nm/s None
Homo sapiens P-glycoprotein 1 Papp 267.0 nm/s None
Homo sapiens P-glycoprotein 1 Ratio_ATPase activity 3.61 None None
Homo sapiens P-glycoprotein 1 Ratio_Papp 3.61 None None
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein-arginine deiminase type-4 IC50 7500000.0 nM 10.1016/j.bmc.2007.10.021
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum albumin Log K' 0.26 None 10.1021/jm010960b
Homo sapiens Serum albumin pKa 0.01 None 10.1021/acs.jmedchem.0c00046
Homo sapiens Serum albumin PPB 3.1 % 10.1021/acs.jmedchem.0c00046
Homo sapiens Serum albumin PPB 37.3 % 10.1021/acs.jmedchem.0c00046
Homo sapiens SK-MEL-2 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens SK-MEL-28 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens SK-MEL-5 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens SN12C TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Solute carrier family 22 member 1 IC50 50680.0 nM 10.1021/acs.jmedchem.6b01317
Homo sapiens Solute carrier family 22 member 1 IC50 56800.0 nM 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Inhibition 58.1 % 10.1021/jm8003152
Homo sapiens Solute carrier family 22 member 1 Ratio 1.26 None 10.1021/acs.jmedchem.6b01317
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 24.7 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 82.92 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 18.8 % 10.1021/jm300212s
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 97.26 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 2B1 Inhibition 35.1 % 10.1021/jm300212s
Homo sapiens SR TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens T47D TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Thromboxane A2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thymidylate synthase IC50 nan None 10.1021/jm701052u
Homo sapiens Thymidylate synthase IC50 nan None 10.1021/jm8006933
Homo sapiens Thymidylate synthase IC50 nan None 10.1021/jm900490a
Homo sapiens Thyroid stimulating hormone receptor Potency 5011.9 nM None
Homo sapiens Trace amine-associated receptor 1 Activity nan None 10.1016/j.ejmech.2016.10.058
Homo sapiens Transthyretin Activity -0.44 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Transthyretin Activity 7.0 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Transthyretin Activity 53.0 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Transthyretin Activity 90.0 % 10.1021/acs.jmedchem.1c00823
Homo sapiens Type-1 angiotensin II receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens U-251 TGI nan None 10.1016/j.bmcl.2016.03.015
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Human respirovirus 3 Human respirovirus 3 EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Influenza A virus Influenza A virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Influenza B virus Influenza B virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Klebsiella aerogenes Dihydrofolate reductase Ratio 1.0 None 10.1021/jm00140a005
Klebsiella aerogenes Klebsiella aerogenes IZ 28.0 mm 10.1007/s00044-012-0104-0
Klebsiella aerogenes Klebsiella aerogenes MIC 0.3 ug.mL-1 10.1021/jm00394a012
Klebsiella aerogenes Klebsiella aerogenes MIC 1.0 ug.mL-1 10.1007/s00044-012-0104-0
Klebsiella aerogenes Klebsiella aerogenes MIC 1.0 ug.mL-1 10.1021/jm00128a043
Klebsiella aerogenes Klebsiella aerogenes MIC 1.0 ug.mL-1 10.1021/jm00396a018
Klebsiella pneumoniae Klebsiella pneumoniae Activity 100.0 % 10.1128/aac.00675-09
Klebsiella pneumoniae Klebsiella pneumoniae ED50 1.3 mg mouse-1 10.1021/jm00140a005
Klebsiella pneumoniae Klebsiella pneumoniae ED50 1.4 mg mouse-1 10.1021/jm00140a005
Klebsiella pneumoniae Klebsiella pneumoniae ED50 8.1 mg mouse-1 10.1021/jm00140a005
Klebsiella pneumoniae Klebsiella pneumoniae IZ 0.0 mm 10.1007/s00044-012-0104-0
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c01169
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.3 ug.mL-1 10.1021/jm00178a007
Klebsiella pneumoniae Klebsiella pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.01381-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1007/s00044-012-0104-0
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm00128a043
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm00394a012
Klebsiella pneumoniae Klebsiella pneumoniae MIC 1.0 ug.mL-1 10.1021/jm00396a018
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1016/j.bmcl.2012.02.019
Klebsiella pneumoniae Klebsiella pneumoniae MIC 2.0 ug.mL-1 10.1039/d2md00260d
Klebsiella pneumoniae Klebsiella pneumoniae MIC 4.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.00011-10
Klebsiella pneumoniae Klebsiella pneumoniae MIC 32.0 ug.mL-1 10.1128/aac.01672-07
Klebsiella pneumoniae Klebsiella pneumoniae MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Klebsiella pneumoniae Klebsiella pneumoniae MIC 64.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Klebsiella pneumoniae Klebsiella pneumoniae MIC 256.0 ug.mL-1 10.1128/aac.00886-08
Klebsiella pneumoniae Klebsiella pneumoniae MIC 5000.0 nM 10.6019/CHEMBL4513161
Klebsiella pneumoniae Klebsiella pneumoniae MIC 10000.0 nM 10.6019/CHEMBL4513141
Lacticaseibacillus casei Lacticaseibacillus casei IC50 17.0 nM 10.1021/jm00212a010
Lacticaseibacillus casei Lacticaseibacillus casei IC50 103.0 nM 10.1021/jm00074a026
Lacticaseibacillus casei Lacticaseibacillus casei IC50 190.0 nM 10.1021/jm00212a010
Lacticaseibacillus casei Lacticaseibacillus casei Inhibition nan % 10.1021/jm00212a010
Lacticaseibacillus casei Lacticaseibacillus casei Ratio IC50 0.09 None 10.1021/jm00212a010
Lactobacillus casei Dihydrofolate reductase IC50 54.0 nM 10.1021/jm980081y
Lactobacillus casei Dihydrofolate reductase IC50 103.0 nM 10.1021/jm00010a022
Lactobacillus casei Dihydrofolate reductase IC50 620.0 nM 10.1021/jm0203534
Lactobacillus casei Dihydrofolate reductase IC50 620.0 nM 10.1021/jm0701977
Lactobacillus casei Dihydrofolate reductase Ki 131.83 nM 10.1021/jm00128a035
Lactobacillus casei Dihydrofolate reductase Log 1/C 6.88 None 10.1021/jm970776j
Lactobacillus casei Dihydrofolate reductase Log 1/Ki app 6.88 None 10.1021/jm00349a003
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcuslactis) Dihydrofolate reductase Activity 6.19 % 10.1021/jm970211n
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcuslactis) Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00128a043
Leishmania major Dihydrofolate reductase IC50 20500.0 nM 10.1016/j.ejmech.2020.112986
Leishmania major Dihydrofolate reductase Ki 120.0 nM 10.1016/j.ejmech.2020.112986
Leishmania major Leishmania major Activity 69.0 % 10.1016/j.ejmech.2018.04.003
Leishmania major Leishmania major Activity 99.0 % 10.1016/j.ejmech.2018.04.003
Leishmania mexicana Leishmania mexicana IC50 100000.0 nM 10.1016/j.ejmech.2014.12.051
Leishmania mexicana Leishmania mexicana Inhibition 30.0 % 10.1016/j.ejmech.2014.12.051
Listeria monocytogenes Listeria monocytogenes Activity nan None 10.1128/aac.00845-09
Listeria monocytogenes Listeria monocytogenes MIC 0.06 ug.mL-1 10.1128/aac.00845-09
Listeria monocytogenes Listeria monocytogenes MIC 1024.0 ug.mL-1 10.1128/aac.01557-09
Listeria monocytogenes Listeria monocytogenes MIC50 0.06 ug.mL-1 10.1128/aac.00845-09
Listeria monocytogenes Listeria monocytogenes MIC90 0.06 ug.mL-1 10.1128/aac.00845-09
Lysinibacillus sphaericus Lysinibacillus sphaericus Activity 16.0 ug ml-1 10.1128/aac.00652-07
Mammalian orthoreovirus 1 Mammalian orthoreovirus 1 EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Micrococcus luteus Micrococcus luteus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c01169
Micrococcus luteus Micrococcus luteus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.9b01185
Moraxella catarrhalis Moraxella catarrhalis MIC 4.0 ug.mL-1 10.1039/d2md00260d
Moraxella catarrhalis Moraxella catarrhalis MIC90 128.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Morganella morganii Morganella morganii Activity 100.0 % 10.1128/aac.00675-09
Mus musculus Dihydrofolate reductase Ki 500.0 nM 10.1016/j.bmc.2009.08.044
Mus musculus Dihydrofolate reductase Log 1/C 3.73 None 10.1021/jm00369a019
Mus musculus Dihydrofolate reductase Log 1/C 5.19 None 10.1021/jm00369a019
Mus musculus J774.A1 Activity 64.3 None 10.1128/aac.00375-07
Mus musculus J774.A1 Activity 90.0 % 10.1128/aac.00375-07
Mus musculus L5178Y Log 1/C 3.73 None 10.1021/jm00347a007
Mus musculus L5178Y Log 1/C 5.19 None 10.1021/jm00347a007
Mus musculus L929 CC30 55.11 uM 10.1016/j.ejmech.2019.111765
Mus musculus Mus musculus Concentration 0.5 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 0.8 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 0.94 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 1.7 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 10.0 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 18.0 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 20.0 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 54.0 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 74.0 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus Concentration 170.0 ug ml-1 10.1021/jm00140a005
Mus musculus Mus musculus ED50 15.0 mg.kg-1 10.1016/j.bmcl.2003.07.023
Mus musculus Mus musculus ED50 60.0 mg.kg-1 10.1016/j.bmcl.2003.07.023
Mus musculus Mus musculus Infection score mean 0.9 None 10.1021/jm9505122
Mus musculus Mus musculus No. of mice infected /total nan None 10.1021/jm9505122
Mus musculus Mus musculus T1/2 0.76 hr 10.1021/jm00140a005
Mus musculus Mus musculus T1/2 2.7 hr 10.1021/jm00140a005
Mus musculus Trace amine-associated receptor 1 Activity nan None 10.1016/j.ejmech.2016.10.058
Mus musculus Trace amine-associated receptor 5 EC50 10000.0 nM 10.1016/j.ejmech.2016.10.058
Mycobacterium avium Dihydrofolate reductase Activity 0.3 uM 10.1016/j.bmc.2010.03.031
Mycobacterium avium Dihydrofolate reductase IC50 190.0 nM 10.1021/jm010407u
Mycobacterium avium Dihydrofolate reductase IC50 190.0 nM 10.1021/jm0701977
Mycobacterium avium Dihydrofolate reductase IC50 190.0 nM 10.1021/jm990331q
Mycobacterium avium Dihydrofolate reductase IC50 300.0 nM 10.1016/j.bmc.2009.11.029
Mycobacterium avium Dihydrofolate reductase IC50 300.0 nM 10.1021/jm020466n
Mycobacterium avium Dihydrofolate reductase IC50 300.0 nM 10.1021/jm030438k
Mycobacterium avium Dihydrofolate reductase IC50 300.0 nM 10.1021/jm030599o
Mycobacterium avium Dihydrofolate reductase IC50 300.0 nM 10.1021/jm0581718
Mycobacterium avium Dihydrofolate reductase IC50 300000.0 nM 10.1021/jm070165j
Mycobacterium avium Mycobacterium avium MIC 64.0 ug.mL-1 10.1021/jm030438k
Mycobacterium tuberculosis Dihydrofolate reductase IC50 88000.0 nM 10.1016/j.bmc.2020.115600
Mycobacterium tuberculosis Dihydrofolate reductase IZ 5.0 mm 10.1016/j.bmc.2007.04.011
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1021/jm00134a003
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1021/jm00196a019
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 25.0 ug.mL-1 10.1021/jm00208a010
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 28930.0 nM 10.1021/acsmedchemlett.5b00367
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 83200.0 nM 10.1128/aac.00055-06
Mycobacterium tuberculosis Mycobacterium tuberculosis MIC 128000.0 nM 10.1128/aac.00055-06
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Inhibition nan % 10.1016/j.bmcl.2011.06.125
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1.0 ug.mL-1 10.1021/jm00128a043
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 1.0 ug.mL-1 10.1021/jm00396a018
Mycolicibacterium smegmatis Mycolicibacterium smegmatis MIC 34000.0 nM 10.1016/j.bmc.2019.04.032
Nakaseomyces glabratus Nakaseomyces glabratus MIC 25.0 ug.mL-1 10.1007/s00044-011-9605-5
Nakaseomyces glabratus Nakaseomyces glabratus MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Neisseria gonorrhoeae Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00106a011
Neisseria gonorrhoeae Dihydrofolate reductase IC50 450.0 nM 10.1021/jm00385a017
Neisseria gonorrhoeae Neisseria gonorrhoeae MIC 240000.0 nM 10.1021/jm00396a018
Oryctolagus cuniculus Oryctolagus cuniculus Concentration 2.0 ug ml-1 10.1021/jm00140a005
Oryctolagus cuniculus Oryctolagus cuniculus T1/2 2.01 hr 10.1021/jm00140a005
Pasteurella multocida Pasteurella multocida MIC 0.25 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida MIC 0.5 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida MIC 1.0 ug.mL-1 10.1021/jm00128a043
Pasteurella multocida Pasteurella multocida MIC 1.0 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida MIC 2.0 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida MIC 8.0 ug.mL-1 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida Ratio 4.0 None 10.1128/aac.00245-08
Pasteurella multocida Pasteurella multocida Ratio 32.0 None 10.1128/aac.00245-08
Phocaeicola vulgatus Phocaeicola vulgatus MIC 6.2 ug.mL-1 10.1021/jm00128a043
Pichia kudriavzevii Pichia kudriavzevii MIC 25.0 ug.mL-1 10.1007/s00044-011-9605-5
Plasmodium berghei Plasmodium berghei MCD 640.0 mg kg-1 10.1021/jm00212a010
Plasmodium berghei Plasmodium berghei MED 640.0 mg kg-1 10.1021/jm00212a010
Plasmodium berghei Plasmodium berghei Ratio 0.6 None 10.1021/jm00208a010
Plasmodium berghei Plasmodium berghei SD90 120.0 mg/kg/day 10.1021/jm00208a010
Plasmodium berghei str. ANKA Dihydrofolate reductase IC50 120.0 nM 10.1021/jm00128a043
Plasmodium berghei str. ANKA Dihydrofolate reductase IC50 120.0 nM 10.1021/jm00178a007
Plasmodium berghei str. ANKA Dihydrofolate reductase IC50 120.0 nM 10.1021/jm00179a012
Plasmodium berghei str. ANKA Dihydrofolate reductase IC50 120.0 nM 10.1021/jm00385a017
Plasmodium berghei str. ANKA Dihydrofolate reductase IC50 120.0 nM 10.1021/jm00394a012
Plasmodium falciparum Plasmodium falciparum IC50 0.38 ug.mL-1 10.1016/j.bmc.2017.10.041
Plasmodium falciparum Plasmodium falciparum IC50 0.38 ug.mL-1 10.1016/j.bmc.2019.06.038
Plasmodium falciparum Plasmodium falciparum IC50 0.38 ug.mL-1 10.1016/j.ejmech.2017.02.012
Plasmodium falciparum Plasmodium falciparum IC50 380.19 nM 10.1016/j.bmc.2019.06.038
Plasmodium falciparum Plasmodium falciparum IC50 406.7 nM 10.1128/aac.00308-09
Plasmodium falciparum Plasmodium falciparum IC50 855.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1096.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1183.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1258.93 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1412.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1503.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 1640.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2032.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2071.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2108.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2155.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2273.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2303.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2481.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2600.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2657.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 2800.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 3162.28 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 3311.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 4100.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 6700.0 nM 10.1021/jm010131q
Plasmodium falciparum Plasmodium falciparum IC50 9308.6 nM 10.1128/aac.00308-09
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 24165.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 29656.0 nM 10.1128/aac.00308-09
Plasmodium falciparum Plasmodium falciparum IC50 29852.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 30000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 32669.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 33655.0 nM 10.1128/aac.00308-09
Plasmodium falciparum Plasmodium falciparum IC50 36531.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 39605.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 39642.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 39806.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 40000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 40053.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 41742.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 43831.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 44582.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 48189.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 48211.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 48456.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 50695.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 59746.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 61785.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 70393.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 101754.0 nM 10.1128/aac.00308-09
Plasmodium falciparum Plasmodium falciparum IC50 117000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 154736.0 nM 10.1128/aac.00308-09
Plasmodium falciparum Plasmodium falciparum IC50 158000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 169000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 194000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum Inhibition 2.0 % 10.1038/nature09107
Plasmodium falciparum Plasmodium falciparum Inhibition 3.0 % 10.1038/nature09107
Plasmodium falciparum Plasmodium falciparum Inhibition 88.0 % 10.1038/nature09107
Plasmodium falciparum Plasmodium falciparum Potency 1471.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 1510.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 2133.1 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Plasmodium falciparum Plasmodium falciparum Ratio 20.4 None 10.1021/jm010131q
Plasmodium falciparum Plasmodium falciparum Safety ratio 7.5 None 10.1021/jm010131q
Plasmodium falciparum Plasmodium falciparum XC50 754.7 nM 10.1038/nature09107
Plasmodium falciparum K1 Dihydrofolate reductase IC50 10.0 nM 10.1016/j.bmcl.2006.05.047
Plasmodium falciparum K1 Dihydrofolate reductase IC50 136500.0 nM 10.1021/jm010131q
Plasmodium falciparum K1 Dihydrofolate reductase Ki 10.3 nM 10.1021/jm010131q
Plasmodium falciparum K1 Dihydrofolate reductase Ki 10.3 nM 10.1021/jm0303352
Plasmodium falciparum K1 Dihydrofolate reductase Ki 132.3 nM 10.1021/jm010131q
Plasmodium falciparum K1 Dihydrofolate reductase Ki 242.1 nM 10.1021/jm010131q
Plasmodium falciparum K1 Dihydrofolate reductase Ki 242.1 nM 10.1021/jm0303352
Plasmodium falciparum K1 Dihydrofolate reductase Ki 5688.7 nM 10.1021/jm0303352
Plasmodium falciparum K1 Dihydrofolate reductase Ki 6664.5 nM 10.1021/jm0303352
Plasmodium falciparum K1 Dihydrofolate reductase Relative activity 1.0 None 10.1021/jm0303352
Plesiomonas shigelloides Plesiomonas shigelloides Activity 0.0 % 10.1128/aac.01260-08
Plesiomonas shigelloides Plesiomonas shigelloides Activity 100.0 % 10.1128/aac.01260-08
Plesiomonas shigelloides Plesiomonas shigelloides MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Plesiomonas shigelloides Plesiomonas shigelloides MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Pneumocystis carinii Dihydrofolate reductase Activity 13.0 uM 10.1016/j.bmc.2010.03.031
Pneumocystis carinii Dihydrofolate reductase IC50 46.0 nM 10.1021/jm030599o
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1016/j.bmc.2009.11.029
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1016/j.bmcl.2006.05.047
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00005a002
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00010a022
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00012a016
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00014a014
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00018a027
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00024a001
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm00052a011
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm030438k
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm0701977
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm800244v
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm800694g
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm950760y
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm950786p
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm9606913
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm960717q
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm960734f
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm970399a
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm970537w
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm9705420
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm970614n
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm980081y
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm980206z
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm980572i
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm990079m
Pneumocystis carinii Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm990331q
Pneumocystis carinii Dihydrofolate reductase IC50 12500.0 nM 10.1021/jm400086g
Pneumocystis carinii Dihydrofolate reductase IC50 13000.0 nM 10.1021/jm020466n
Pneumocystis carinii Dihydrofolate reductase IC50 13000.0 nM 10.1021/jm030599o
Pneumocystis carinii Dihydrofolate reductase IC50 13000.0 nM 10.1021/jm0581718
Pneumocystis carinii Dihydrofolate reductase IC50 15000.0 nM 10.1021/jm0202369
Pneumocystis carinii Dihydrofolate reductase IC50 26800.0 nM 10.1021/jm010856u
Pneumocystis carinii Dihydrofolate reductase IC50 40000.0 nM 10.1021/jm00074a026
Pneumocystis carinii Dihydrofolate reductase IC50 43000.0 nM 10.1016/j.bmcl.2003.07.023
Pneumocystis carinii Dihydrofolate reductase IC50 12000000.0 nM 10.1021/jm070165j
Pneumocystis carinii Dihydrofolate reductase Ki 151.36 nM 10.1021/jm00006a016
Pneumocystis carinii Dihydrofolate reductase Ki 152.0 nM 10.1021/jm00024a001
Pneumocystis carinii Dihydrofolate reductase Ki 280000.0 nM 10.1016/j.ejmech.2017.04.070
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Ratio 11.0 None 10.1021/jm00052a011
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Ratio 11.1 None 10.1021/jm00010a022
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity 11.0 None 10.1021/jm00005a002
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity 11.0 None 10.1021/jm980206z
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity 11.1 None 10.1021/jm950760y
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity index 4.5 None 10.1021/jm010856u
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity index 14.0 None 10.1021/jm020466n
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity index 14.0 None 10.1021/jm0581718
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity ratio 11.1 Ratio 10.1021/jm950786p
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity ratio 11.1 None 10.1021/jm00018a027
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity ratio 11.1 None 10.1021/jm9606913
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity ratio 11.1 None 10.1021/jm960734f
Pneumocystis carinii Dihydrofolate reductase; P. carinii vs rat Selectivity ratio 11.1 None 10.1021/jm970537w
Pneumocystis carinii Pneumocystis carinii IC50 0.0 nM 10.1016/j.bmc.2010.01.068
Pneumocystis carinii Pneumocystis carinii Inhibition 84.0 % 10.1021/jm00074a026
Pneumocystis jirovecii Dihydrofolate reductase IC50 92.0 nM 10.1016/j.bmc.2018.04.032
Proteus mirabilis Proteus mirabilis Activity 100.0 % 10.1128/aac.00675-09
Proteus mirabilis Proteus mirabilis MIC 0.19 ug.mL-1 10.1128/aac.01094-07
Proteus mirabilis Proteus mirabilis MIC 0.25 ug.mL-1 10.1128/aac.01094-07
Proteus mirabilis Proteus mirabilis MIC 0.4 ug.mL-1 10.1128/aac.01094-07
Proteus mirabilis Proteus mirabilis MIC 4.0 ug.mL-1 10.1128/aac.00111-10
Proteus mirabilis Proteus mirabilis MIC 32.0 ug.mL-1 10.1128/aac.01094-07
Proteus mirabilis Proteus mirabilis MIC 128.0 ug.mL-1 10.1128/aac.01400-08
Proteus vulgaris Proteus vulgaris ED50 1.5 mg mouse-1 10.1021/jm00140a005
Proteus vulgaris Proteus vulgaris ED50 2.6 mg mouse-1 10.1021/jm00140a005
Proteus vulgaris Proteus vulgaris MIC 1.0 ug.mL-1 10.1021/jm00128a043
Proteus vulgaris Proteus vulgaris MIC 1.0 ug.mL-1 10.1021/jm00178a007
Proteus vulgaris Proteus vulgaris MIC 1.0 ug.mL-1 10.1021/jm00394a012
Proteus vulgaris Proteus vulgaris MIC 1.0 ug.mL-1 10.1021/jm00396a018
Proteus vulgaris Proteus vulgaris MIC 1.0 None 10.1021/jm00381a008
Proteus vulgaris Proteus vulgaris MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/jm00205a009
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI 1.0 None 10.1016/j.ejmech.2020.112268
Pseudomonas aeruginosa Pseudomonas aeruginosa FICI 2.0 None 10.1016/j.ejmech.2020.112268
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 0.0 mm 10.1016/j.ejmech.2020.112969
Pseudomonas aeruginosa Pseudomonas aeruginosa IZ 31.0 mm 10.1007/s00044-012-0104-0
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.0 ug.mL-1 10.1007/s00044-012-0104-0
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1039/d2md00260d
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 25.0 ug.mL-1 10.1021/jm00134a003
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 25.0 ug.mL-1 10.1021/jm00196a019
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 25.0 ug.mL-1 10.1021/jm00208a010
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.02.019
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 256.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 500.0 ug.mL-1 10.1016/j.ejmech.2019.111744
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 512.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1024.0 ug.mL-1 10.1021/acs.jmedchem.6b01742
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 5000.0 nM 10.6019/CHEMBL4513161
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 10000.0 nM 10.6019/CHEMBL4513141
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 110000.0 nM 10.1016/j.ejmech.2020.112268
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC90 nan None 10.1016/j.ejmech.2017.12.089
Pseudomonas fluorescens Pseudomonas fluorescens IZ 0.0 mm 10.1007/s00044-012-0104-0
Pseudomonas fluorescens Pseudomonas fluorescens MIC 1.0 ug.mL-1 10.1007/s00044-012-0104-0
Punta Toro virus Punta Toro virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Dihydrofolate reductase Activity 180.0 uM 10.1016/j.bmc.2010.03.031
Rattus norvegicus Dihydrofolate reductase Activity 26000.0 10'-8M 10.1021/jm00211a020
Rattus norvegicus Dihydrofolate reductase IC50 0.0026 nM 10.1021/jm00128a042
Rattus norvegicus Dihydrofolate reductase IC50 34000.0 nM 10.1021/jm00396a018
Rattus norvegicus Dihydrofolate reductase IC50 40000.0 nM 10.1021/jm00074a026
Rattus norvegicus Dihydrofolate reductase IC50 121000.0 nM 10.1021/jm010856u
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm00005a002
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm00014a014
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm00052a011
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm010407u
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm950918e
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm970399a
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm970614n
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm980572i
Rattus norvegicus Dihydrofolate reductase IC50 130000.0 nM 10.1021/jm990331q
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm00010a022
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm00012a016
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm00018a027
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm030312n
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm0701977
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm800694g
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm950760y
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm950786p
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm9606913
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm960717q
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm960734f
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm970537w
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm9705420
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm980081y
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm980206z
Rattus norvegicus Dihydrofolate reductase IC50 133000.0 nM 10.1021/jm990079m
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1016/j.bmc.2009.11.029
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1021/jm020466n
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1021/jm030438k
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1021/jm030599o
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1021/jm0581718
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1021/jm400086g
Rattus norvegicus Dihydrofolate reductase IC50 180000.0 nM 10.1021/jm800244v
Rattus norvegicus Dihydrofolate reductase IC50 190000.0 nM 10.1021/jm030931w
Rattus norvegicus Dihydrofolate reductase IC50 260000.0 nM 10.1021/jm00108a022
Rattus norvegicus Dihydrofolate reductase IC50 260000.0 nM 10.1021/jm00128a043
Rattus norvegicus Dihydrofolate reductase IC50 260000.0 nM 10.1021/jm00140a005
Rattus norvegicus Dihydrofolate reductase IC50 260000.0 nM 10.1021/jm00178a007
Rattus norvegicus Dihydrofolate reductase IC50 260000.0 nM 10.1021/jm00179a012
Rattus norvegicus Dihydrofolate reductase IC50 260000.0 nM 10.1021/jm00394a012
Rattus norvegicus Dihydrofolate reductase IC50 300000.0 nM 10.1021/jm00128a043
Rattus norvegicus Dihydrofolate reductase IC50 340000.0 nM 10.1021/jm00128a040
Rattus norvegicus Dihydrofolate reductase IC50 340000.0 nM 10.1021/jm00128a041
Rattus norvegicus Dihydrofolate reductase IC50 340000.0 nM 10.1021/jm00381a008
Rattus norvegicus Dihydrofolate reductase IC50 370000.0 nM 10.1021/jm00106a011
Rattus norvegicus Dihydrofolate reductase IC50 370000.0 nM 10.1021/jm00385a017
Rattus norvegicus Dihydrofolate reductase IC50 180000000.0 nM 10.1021/jm070165j
Rattus norvegicus Dihydrofolate reductase Ki 14300.0 nM 10.1016/j.bmc.2009.08.044
Rattus norvegicus Dihydrofolate reductase Log 1/C 3.5 None 10.1021/jm00373a016
Rattus norvegicus Dihydrofolate reductase Log 1/C 4.2 None 10.1021/jm00361a012
Rattus norvegicus Dihydrofolate reductase SI 11.0 None 10.1021/jm010407u
Rattus norvegicus Dihydrofolate reductase SI 44.0 None 10.1021/jm010407u
Rattus norvegicus Dihydrofolate reductase SI 680.0 None 10.1021/jm010407u
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 14125.4 nM None
Rattus norvegicus Plasma Fu 0.5 None 10.1021/jm901371v
Rattus norvegicus Plasma logFu 0.63 None 10.1016/j.ejmech.2009.06.004
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Respiratory syncytial virus Respiratory syncytial virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 4610.9 nM None
Saccharomyces cerevisiae S288c Dihydrofolate reductase IC50 12000.0 nM 10.1021/jm950918e
Saccharomyces cerevisiae S288c Dihydrofolate reductase IZ 6.0 mm 10.1016/j.bmc.2007.04.011
Salmonella Salmonella MIC 0.03 ug.mL-1 10.1021/jm00394a012
Salmonella Salmonella MIC 0.3 ug.mL-1 10.1021/jm00178a007
Salmonella Salmonella MIC 1.0 ug.mL-1 10.1021/jm00396a018
Salmonella enterica Salmonella enterica MIC 64.0 ug.mL-1 10.1128/aac.00310-09
Salmonella enterica subsp. enterica Salmonella enterica subsp. enterica MIC 1.0 ug.mL-1 10.1128/aac.00854-07
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis Activity 8.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis Activity 91.1 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC 500.0 nM 10.1021/jm030003x
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi Activity 8.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi Activity 91.1 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Dihydrofolate reductase Ki 8.318 nM 10.1021/jm00105a008
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi Activity 8.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi Activity 91.1 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhi Salmonella typhi MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 8.9 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium Activity 91.1 % 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 50.0 ug.mL-1 10.1007/s00044-011-9605-5
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC90 nan None 10.1016/j.ejmech.2017.12.089
Serratia marcescens Serratia marcescens MIC 1.0 ug.mL-1 10.1021/jm00128a043
Serratia marcescens Serratia marcescens MIC 1.0 ug.mL-1 10.1021/jm00396a018
Serratia marcescens Serratia marcescens MIC 3.0 ug.mL-1 10.1021/jm00178a007
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 1.7 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 12.64 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.04 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.03 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.15 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.0604 None 10.1101/2020.04.03.023846
Shigella boydii Shigella boydii Activity 32.7 % 10.1128/aac.01260-08
Shigella boydii Shigella boydii Activity 67.3 % 10.1128/aac.01260-08
Shigella boydii Shigella boydii MIC50 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella boydii Shigella boydii MIC90 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae Activity 32.7 % 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae Activity 67.3 % 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae MIC 0.1 ug.mL-1 10.1021/jm00178a007
Shigella dysenteriae Shigella dysenteriae MIC 1.0 ug.mL-1 10.1021/jm00128a043
Shigella dysenteriae Shigella dysenteriae MIC50 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella dysenteriae Shigella dysenteriae MIC90 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri Activity 16.0 ug ml-1 10.1128/aac.00652-07
Shigella flexneri Shigella flexneri Activity 32.7 % 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri Activity 67.3 % 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri MIC 0.1 ug.mL-1 10.1021/jm00394a012
Shigella flexneri Shigella flexneri MIC 1.0 ug.mL-1 10.1021/jm00128a043
Shigella flexneri Shigella flexneri MIC 1.0 ug.mL-1 10.1021/jm00396a018
Shigella flexneri Shigella flexneri MIC50 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella flexneri Shigella flexneri MIC90 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei Activity 32.7 % 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei Activity 67.3 % 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei Activity nan None 10.1021/jm00205a009
Shigella sonnei Shigella sonnei MIC 0.25 ug.mL-1 10.1021/jm00196a019
Shigella sonnei Shigella sonnei MIC 0.25 ug.mL-1 10.1021/jm00208a010
Shigella sonnei Shigella sonnei MIC 25.0 ug.mL-1 10.1021/jm00134a003
Shigella sonnei Shigella sonnei MIC50 64.0 ug.mL-1 10.1128/aac.01260-08
Shigella sonnei Shigella sonnei MIC90 64.0 ug.mL-1 10.1128/aac.01260-08
Sindbis virus Sindbis virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Staphylococcus Staphylococcus Activity 48.0 % 10.1128/aac.00845-09
Staphylococcus Staphylococcus MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Staphylococcus Staphylococcus MIC50 16.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus Staphylococcus MIC90 32.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Dihydrofolate reductase IC50 7.0 nM 10.1016/j.bmcl.2003.07.023
Staphylococcus aureus Dihydrofolate reductase IC50 14.4 nM 10.1128/aac.00361-10
Staphylococcus aureus Dihydrofolate reductase IC50 23.0 nM 10.1039/C3MD00104K
Staphylococcus aureus Dihydrofolate reductase IC50 27.0 nM 10.1021/jm020495y
Staphylococcus aureus Dihydrofolate reductase IC50 539.7 nM 10.1128/aac.00361-10
Staphylococcus aureus Dihydrofolate reductase IC50 1700.0 nM 10.1039/C3MD00104K
Staphylococcus aureus Dihydrofolate reductase IC50 10243.0 nM 10.1128/aac.00377-09
Staphylococcus aureus Dihydrofolate reductase IC50 19000.0 nM 10.1021/jm020495y
Staphylococcus aureus Dihydrofolate reductase IC50 45000.0 nM 10.1021/jm070319v
Staphylococcus aureus Dihydrofolate reductase IC50 15848931.92 nM 10.1021/jm00163a067
Staphylococcus aureus Dihydrofolate reductase Ki 1.2 nM 10.1021/jm401204g
Staphylococcus aureus Dihydrofolate reductase Ki 1.24 nM 10.1016/j.bmcl.2011.07.059
Staphylococcus aureus Dihydrofolate reductase Ki 3.43 nM 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Dihydrofolate reductase Ki 3.43 nM 10.1021/acsmedchemlett.6b00120
Staphylococcus aureus Dihydrofolate reductase Ki 4.4 nM 10.1128/aac.00361-10
Staphylococcus aureus Dihydrofolate reductase Ki 5.1 nM 10.1021/jm00128a043
Staphylococcus aureus Dihydrofolate reductase Ki 6.89 nM 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Dihydrofolate reductase Ki 14.68 nM 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Dihydrofolate reductase Ki 53.6 nM 10.1128/aac.00361-10
Staphylococcus aureus Dihydrofolate reductase Ki 90.0 nM 10.1016/j.bmcl.2011.07.059
Staphylococcus aureus Dihydrofolate reductase Ki 240.8 nM 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Dihydrofolate reductase Ki 595.1 nM 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Dihydrofolate reductase Ki 1729.0 nM 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Dihydrofolate reductase log(1/I50) 1.5 None 10.1021/jm00211a020
Staphylococcus aureus Dihydrofolate reductase MIC 32.0 ug.mL-1 10.1021/jm020495y
Staphylococcus aureus Dihydrofolate reductase Ratio 1.0 None 10.1021/jm00140a005
Staphylococcus aureus Staphylococcus aureus Activity 0.0 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 0.1 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 0.3 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 1.3 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 2.4 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 7.1 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 71.0 % 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity 80.0 % 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity 92.0 % 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus Activity 92.9 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Activity 98.7 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus ED50 1.3 mg mouse-1 10.1021/jm00140a005
Staphylococcus aureus Staphylococcus aureus ED50 3.1 mg.kg-1 10.1128/aac.00377-09
Staphylococcus aureus Staphylococcus aureus ED50 6.1 mg mouse-1 10.1021/jm00140a005
Staphylococcus aureus Staphylococcus aureus ED50 6.25 mg.kg-1 10.1128/aac.00377-09
Staphylococcus aureus Staphylococcus aureus ED50 7.3 mg mouse-1 10.1021/jm00140a005
Staphylococcus aureus Staphylococcus aureus FC 0.88 None 10.1128/aac.00273-08
Staphylococcus aureus Staphylococcus aureus FC 0.9 None 10.1128/aac.00273-08
Staphylococcus aureus Staphylococcus aureus FC 0.92 None 10.1128/aac.00273-08
Staphylococcus aureus Staphylococcus aureus FC 1.19 None 10.1128/aac.00273-08
Staphylococcus aureus Staphylococcus aureus FC 1.24 None 10.1128/aac.00273-08
Staphylococcus aureus Staphylococcus aureus FIC 0.06 None 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus FICI 0.12 None 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus Inhibition 0.1 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 0.2 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 5.7 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 34.3 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 47.7 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 88.5 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 90.2 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 92.1 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 92.5 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 92.9 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 93.6 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 94.1 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 94.6 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 97.8 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 98.5 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 98.7 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus Inhibition 100.0 % 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus IZ 6.0 mm 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus IZ 20.19 mm 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus IZ 22.0 mm 10.1016/j.ejmech.2020.112969
Staphylococcus aureus Staphylococcus aureus IZ 22.8 mm 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus IZ 37.0 mm 10.1007/s00044-012-0104-0
Staphylococcus aureus Staphylococcus aureus Log 1/MIC 3.1 None 10.1021/jm00163a067
Staphylococcus aureus Staphylococcus aureus MBC 1.25 ug ml-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MBC 2.5 ug ml-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MBC 10.0 ug ml-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MIC 0.008 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.03 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC 0.06 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00134a003
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00196a019
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00205a009
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1021/jm00208a010
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00064-10
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00377-09
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC 0.25 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 0.3 ug.mL-1 10.1021/jm00394a012
Staphylococcus aureus Staphylococcus aureus MIC 0.3125 ug.mL-1 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Staphylococcus aureus MIC 0.3125 ug.mL-1 10.1021/acsmedchemlett.6b00120
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00570-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01091-09
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 0.62 ug.mL-1 10.1039/C3MD00104K
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1007/s00044-012-0104-0
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2011.07.059
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.bmcl.2012.02.019
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm00128a043
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm00178a007
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm00396a018
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1021/jm401204g
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.00377-09
Staphylococcus aureus Staphylococcus aureus MIC 1.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 1.0 None 10.1021/jm00381a008
Staphylococcus aureus Staphylococcus aureus MIC 1.25 ug.mL-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MIC 1.5 ug.mL-1 10.1039/C3MD00104K
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2021.113979
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.2c01169
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1021/acs.jnatprod.9b01185
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00209-07
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00361-10
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1128/aac.00915-08
Staphylococcus aureus Staphylococcus aureus MIC 2.5 ug.mL-1 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1016/j.bmc.2010.02.005
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2020.113134
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1039/d2md00260d
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1128/aac.00209-07
Staphylococcus aureus Staphylococcus aureus MIC 5.0 ug.mL-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MIC 6.25 ug.mL-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1039/d2md00260d
Staphylococcus aureus Staphylococcus aureus MIC 10.0 ug.mL-1 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Staphylococcus aureus MIC 12.5 ug.mL-1 10.1016/j.bmc.2018.05.019
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1016/j.bmcl.2011.07.059
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1021/jm401204g
Staphylococcus aureus Staphylococcus aureus MIC 32.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 50.0 ug.mL-1 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Staphylococcus aureus MIC 64.0 ug.mL-1 10.1021/acs.jnatprod.9b01185
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1007/s00044-011-9605-5
Staphylococcus aureus Staphylococcus aureus MIC 100.0 ug.mL-1 10.1021/acs.jmedchem.6b00688
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.00377-09
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.00464-10
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.01091-09
Staphylococcus aureus Staphylococcus aureus MIC 128.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC 250.0 ug.mL-1 10.1016/j.ejmech.2019.111744
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1128/aac.00361-10
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1128/aac.01124-10
Staphylococcus aureus Staphylococcus aureus MIC 256.0 ug.mL-1 10.1128/aac.01128-08
Staphylococcus aureus Staphylococcus aureus MIC 512.0 ug.mL-1 10.1128/aac.00570-09
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1021/acsmedchemlett.0c00425
Staphylococcus aureus Staphylococcus aureus MIC 5000.0 nM 10.6019/CHEMBL4513141
Staphylococcus aureus Staphylococcus aureus MIC 5000.0 nM 10.6019/CHEMBL4513161
Staphylococcus aureus Staphylococcus aureus MIC 6250.0 nM 10.1016/j.bmcl.2022.129086
Staphylococcus aureus Staphylococcus aureus MIC 12500.0 nM 10.1016/j.bmcl.2022.129086
Staphylococcus aureus Staphylococcus aureus MIC 22700.0 nM 10.1016/j.bmcl.2016.10.051
Staphylococcus aureus Staphylococcus aureus MIC nan None 10.1128/aac.00273-08
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC50 0.25 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC50 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus MIC50 1.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC50 128.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 1.0 ug.mL-1 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1128/aac.00129-09
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC90 2.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 8.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Staphylococcus aureus Staphylococcus aureus MIC90 16.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC90 32.0 ug.mL-1 10.1128/aac.00845-09
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Staphylococcus aureus Staphylococcus aureus MIC90 64.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 128.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus aureus Staphylococcus aureus MIC90 22700.0 nM 10.1016/j.ejmech.2017.12.089
Staphylococcus aureus Staphylococcus aureus Ratio 1.09 None 10.1016/j.bmcl.2011.06.125
Staphylococcus epidermidis Staphylococcus epidermidis IZ 29.0 mm 10.1007/s00044-012-0104-0
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.0 ug.mL-1 10.1007/s00044-012-0104-0
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.25 ug.mL-1 10.1128/aac.00377-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 0.5 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1039/d2md00260d
Staphylococcus epidermidis Staphylococcus epidermidis MIC 32.0 ug.mL-1 10.1128/aac.00377-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1016/j.bmcl.2012.02.019
Staphylococcus epidermidis Staphylococcus epidermidis MIC 64.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1128/aac.00377-09
Staphylococcus epidermidis Staphylococcus epidermidis MIC 128.0 ug.mL-1 10.1128/aac.01619-08
Staphylococcus lugdunensis Staphylococcus lugdunensis MIC 16.0 ug.mL-1 10.1128/aac.01052-06
Streptococcus agalactiae Streptococcus agalactiae MIC90 128.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Streptococcus mitis Streptococcus mitis MIC 0.008 ug.mL-1 10.1128/aac.00845-09
Streptococcus mitis Streptococcus mitis MIC50 4.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae Activity 30.2 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity 38.4 % 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae Activity nan None 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1021/jm401204g
Streptococcus pneumoniae Streptococcus pneumoniae MIC 0.5 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 1.0 ug.mL-1 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC 2.0 ug.mL-1 10.1128/aac.00377-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC 4.0 ug.mL-1 10.1021/jm401204g
Streptococcus pneumoniae Streptococcus pneumoniae MIC 8.0 ug.mL-1 10.1021/jm401204g
Streptococcus pneumoniae Streptococcus pneumoniae MIC 64.0 ug.mL-1 10.1021/jm401204g
Streptococcus pneumoniae Streptococcus pneumoniae MIC 128.0 ug.mL-1 10.1128/aac.00377-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC nan None 10.1128/aac.00377-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 1.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 2.0 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 4.0 ug.mL-1 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC50 8.0 ug.mL-1 10.1021/jm401204g
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 4.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 8.0 ug.mL-1 10.1128/aac.01384-06
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 32.0 ug.mL-1 10.1128/aac.01332-07
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 64.0 ug.mL-1 10.1021/jm401204g
Streptococcus pneumoniae Streptococcus pneumoniae MIC90 128.0 ug.mL-1 10.1016/j.bmcl.2003.07.023
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Dihydrofolate reductase IC50 42000.0 nM 10.1021/jm070319v
Streptococcus pyogenes Streptococcus pyogenes ED50 3.7 mg mouse-1 10.1021/jm00140a005
Streptococcus pyogenes Streptococcus pyogenes ED50 6.1 mg mouse-1 10.1021/jm00140a005
Streptococcus pyogenes Streptococcus pyogenes ED50 8.6 mg mouse-1 10.1021/jm00140a005
Streptococcus pyogenes Streptococcus pyogenes MIC 0.3 ug.mL-1 10.1021/jm00178a007
Streptococcus pyogenes Streptococcus pyogenes MIC 1.0 ug.mL-1 10.1021/jm00128a043
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Activity nan None 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Activity nan None 10.1128/aac.00845-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 0.8 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 8.6 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 45.9 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 84.6 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 98.5 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 99.5 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' Inhibition 100.0 % 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 0.03 ug.mL-1 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC 0.12 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 0.25 ug.mL-1 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC50 0.5 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 0.5 ug.mL-1 10.1128/aac.00129-09
Streptococcus sp. 'group A' Streptococcus sp. 'group A' MIC90 1.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Activity nan None 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Activity nan None 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 0.0 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 0.5 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 5.9 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 51.0 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 89.2 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 99.5 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' Inhibition 100.0 % 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.25 ug.mL-1 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC 0.25 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC50 1.0 ug.mL-1 10.1128/aac.00129-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC50 1.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC90 1.0 ug.mL-1 10.1128/aac.00845-09
Streptococcus sp. 'group B' Streptococcus sp. 'group B' MIC90 4.0 ug.mL-1 10.1128/aac.00129-09
Toxoplasma gondii Dihydrofolate reductase Activity 0.33 None 10.1021/jm061027h
Toxoplasma gondii Dihydrofolate reductase Activity 2.8 uM 10.1016/j.bmc.2010.03.031
Toxoplasma gondii Dihydrofolate reductase IC50 7.2 nM 10.1021/jm980081y
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm00005a002
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm00010a022
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm00012a016
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm00014a014
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm00018a027
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm00052a011
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm010407u
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm010856u
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm800694g
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm950786p
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm950918e
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm9606913
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm960717q
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm960734f
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm970399a
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm970537w
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm9705420
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm970614n
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm980081y
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm980206z
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm980572i
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm990079m
Toxoplasma gondii Dihydrofolate reductase IC50 2700.0 nM 10.1021/jm990331q
Toxoplasma gondii Dihydrofolate reductase IC50 2730.0 nM 10.1021/jm0701977
Toxoplasma gondii Dihydrofolate reductase IC50 2730.0 nM 10.1021/jm950760y
Toxoplasma gondii Dihydrofolate reductase IC50 2800.0 nM 10.1016/j.bmc.2009.11.029
Toxoplasma gondii Dihydrofolate reductase IC50 2800.0 nM 10.1021/jm020466n
Toxoplasma gondii Dihydrofolate reductase IC50 2800.0 nM 10.1021/jm030438k
Toxoplasma gondii Dihydrofolate reductase IC50 2800.0 nM 10.1021/jm030599o
Toxoplasma gondii Dihydrofolate reductase IC50 2800.0 nM 10.1021/jm0581718
Toxoplasma gondii Dihydrofolate reductase IC50 2900.0 nM 10.1021/jm800244v
Toxoplasma gondii Dihydrofolate reductase IC50 3400.0 nM 10.1021/jm0202369
Toxoplasma gondii Dihydrofolate reductase IC50 3700.0 nM 10.1021/jm0100382
Toxoplasma gondii Dihydrofolate reductase IC50 6800.0 nM 10.1016/j.bmc.2012.05.068
Toxoplasma gondii Dihydrofolate reductase IC50 6800.0 nM 10.1021/jm8006933
Toxoplasma gondii Dihydrofolate reductase IC50 6800.0 nM 10.1021/jm900490a
Toxoplasma gondii Dihydrofolate reductase IC50 8000.0 nM 10.1021/jm061027h
Toxoplasma gondii Dihydrofolate reductase IC50 10000.0 nM 10.1021/jm00074a026
Toxoplasma gondii Dihydrofolate reductase IC50 33100.0 nM 10.1021/acs.jmedchem.8b01754
Toxoplasma gondii Dihydrofolate reductase IC50 2800000.0 nM 10.1021/jm070165j
Toxoplasma gondii Dihydrofolate reductase IC50 nan None 10.1021/jm8006933
Toxoplasma gondii Dihydrofolate reductase IC50 nan None 10.1021/jm900490a
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Ratio 44.0 None 10.1021/jm00052a011
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Ratio 49.0 None 10.1021/jm00010a022
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity 48.0 None 10.1021/jm00005a002
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity 48.7 None 10.1021/jm950760y
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity 49.0 None 10.1021/jm980206z
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity index 44.8 None 10.1021/jm010856u
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity index 65.0 None 10.1021/jm020466n
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity index 65.0 None 10.1021/jm0581718
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity ratio 49.0 Ratio 10.1021/jm950786p
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity ratio 49.0 None 10.1021/jm9606913
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity ratio 49.0 None 10.1021/jm960734f
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity ratio 49.0 None 10.1021/jm970537w
Toxoplasma gondii Dihydrofolate reductase; T. gondii vs rat Selectivity ratio 49.26 None 10.1021/jm00018a027
Toxoplasma gondii Toxoplasma gondii Activity 36.0 None 10.1016/j.ejmech.2022.114812
Toxoplasma gondii Toxoplasma gondii Activity nan None 10.1016/j.ejmech.2022.114812
Toxoplasma gondii Toxoplasma gondii IC50 0.0 nM 10.1016/j.bmc.2010.01.068
Toxoplasma gondii Toxoplasma gondii IC50 13000.0 nM 10.1016/j.ejmech.2014.08.046
Toxoplasma gondii Toxoplasma gondii IC50 14000.0 nM 10.1021/jm9005862
Toxoplasma gondii Toxoplasma gondii IC50 39230.0 nM 10.1016/j.ejmech.2019.111765
Toxoplasma gondii Toxoplasma gondii IC50 41780.0 nM 10.1016/j.ejmech.2019.111765
Toxoplasma gondii Toxoplasma gondii IC50 46000.0 nM 10.1021/jm901857d
Toxoplasma gondii Toxoplasma gondii IC90 73000.0 nM 10.1016/j.ejmech.2014.08.046
Toxoplasma gondii Toxoplasma gondii IC90 nan None 10.1021/jm9005862
Toxoplasma gondii Toxoplasma gondii ID50 15.0 uM 10.1016/j.bmcl.2012.02.038
Toxoplasma gondii Toxoplasma gondii ID50 15.0 uM 10.1016/j.bmcl.2012.12.024
Toxoplasma gondii Toxoplasma gondii Inhibition nan % 10.1016/j.ejmech.2014.08.046
Trypanosoma brucei Trypanosoma brucei IC50 148000.0 nM 10.1021/jm981130+
Vesicular stomatitis virus Vesicular stomatitis virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Vibrio alginolyticus Vibrio alginolyticus Activity 0.0 % 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus Activity 100.0 % 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus MIC 0.125 ug.mL-1 10.1021/acs.jnatprod.2c01169
Vibrio alginolyticus Vibrio alginolyticus MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio alginolyticus Vibrio alginolyticus MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae Activity 0.0 % 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae Activity 100.0 % 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae MIC 1.0 ug.mL-1 10.1021/jm00396a018
Vibrio cholerae Vibrio cholerae MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio cholerae Vibrio cholerae MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis Activity 0.0 % 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis Activity 100.0 % 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio fluvialis Vibrio fluvialis MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus Activity 0.0 % 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus Activity 100.0 % 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. Activity 0.0 % 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. Activity 100.0 % 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio sp. Vibrio sp. MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus Activity 0.0 % 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus Activity 100.0 % 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus MIC 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Vibrio vulnificus Vibrio vulnificus MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Yellow fever virus Yellow fever virus EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
Yersinia enterocolitica Yersinia enterocolitica Activity 6.5 % 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica Activity 93.5 % 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Yersinia enterocolitica Yersinia enterocolitica MIC90 2.0 ug.mL-1 10.1128/aac.01260-08
Yersinia pestis Yersinia pestis MIC 1.0 ug.mL-1 10.1128/aac.00361-10
Yersinia pseudotuberculosis Yersinia pseudotuberculosis Activity 6.5 % 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis Activity 93.5 % 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
Yersinia pseudotuberculosis Yersinia pseudotuberculosis MIC90 2.0 ug.mL-1 10.1128/aac.01260-08
None ADMET Activity nan None 10.1016/j.ejmech.2022.114812
None ADMET Binding energy 11.5 kCal mol-1 10.1021/jm00378a021
None ADMET CL 2.1 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 3.0 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 8.6 mL.min-1.kg-1 10.1021/acs.jmedchem.8b01754
None ADMET delta logD -0.57 None 10.1021/jm0000564
None ADMET eLog D 0.61 None 10.1021/jm0200409
None ADMET F 80.0 % 10.1021/jm0000564
None ADMET F 99.0 % 10.1021/jm00128a043
None ADMET Fraction ionised 0.319 None 10.1021/jm0200409
None ADMET Fu 0.166 None 10.1021/jm0200409
None ADMET Fu 0.63 None 10.1021/jm0200409
None ADMET Fu 0.63 None 10.1021/jm030408h
None ADMET Kd 1.0 None 10.1021/jm00352a002
None ADMET log10(%HIA +10) 2.029 None 10.1016/j.ejmech.2010.11.005
None ADMET LogP app -5.5 None 10.1016/j.bmc.2007.03.040
None ADMET LogP app -5.38 None 10.1016/j.bmc.2007.03.040
None ADMET MRT 12.0 hr 10.1124/dmd.108.020479
None ADMET Papp 4.18 10^-6 cm/s 10.1016/j.bmc.2007.03.040
None ADMET Papp 7.5 10'-6 cm/s 10.1021/acs.jmedchem.8b01754
None ADMET Papp 11.2 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 11.6 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 15.9 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 26.8 ucm/s 10.1124/dmd.110.034629
None ADMET PPB 37.5 % 10.1021/acs.jmedchem.0c00046
None ADMET PPB 66.1 % 10.6019/CHEMBL3301361
None ADMET Ratio -4.0 None 10.1124/dmd.110.034629
None ADMET Ratio 0.4 None 10.1124/dmd.110.034629
None ADMET Ratio 0.7 None 10.1124/dmd.110.034629
None ADMET Ratio 3.5 None 10.1021/acs.jmedchem.8b01754
None ADMET Ratio 38.0 None 10.1124/dmd.110.034629
None ADMET Ratio 68.0 None 10.1124/dmd.110.034629
None ADMET T1/2 9.6 hr 10.1124/dmd.108.020479
None ADMET TD50 500.0 uM 10.1016/j.bmcl.2012.02.038
None ADMET TI 3.0 None 10.1016/j.bmcl.2012.02.038
None ADMET TI 3.0 None 10.1016/j.bmcl.2012.12.024
None ADMET TI 12.0 None 10.1021/jm901857d
None ADMET TI 41.0 None 10.1021/jm9005862
None ADMET TI 43.0 None 10.1016/j.ejmech.2014.08.046
None ADMET Toxic index 2.9 None 10.1021/jm00128a035
None ADMET Vdss 1.5 L.kg-1 10.1124/dmd.108.020479
None ADMET Vdss 1.6 L.kg-1 10.1021/jm0200409
None ADMET Vdss 1.6 L.kg-1 10.1021/jm030408h
None BC IC50 250000.0 nM 10.1021/jm010131q
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Activity 8.9 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity 14.9 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity 16.0 ug ml-1 10.1128/aac.00652-07
None NON-PROTEIN TARGET Activity 85.1 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity 91.1 % 10.1128/aac.01260-08
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00427-09
None NON-PROTEIN TARGET Activity nan None 10.1128/aac.00845-09
None NON-PROTEIN TARGET Fu 0.5 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI nan None 10.1021/jm300644g
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 1.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 5.9 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 11700.0 nM 10.1021/jm00212a010
None NON-PROTEIN TARGET IC50 67500.0 nM 10.1021/jm00212a010
None NON-PROTEIN TARGET Inhibition nan % 10.1021/jm00212a010
None NON-PROTEIN TARGET MIC 0.008 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC 0.5 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC 1.0 ug.mL-1 10.1021/jm00128a043
None NON-PROTEIN TARGET MIC 1.0 None 10.1021/jm00381a008
None NON-PROTEIN TARGET MIC 4.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 8.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.00361-10
None NON-PROTEIN TARGET MIC 16.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC 32.0 ug.mL-1 10.1128/aac.01052-07
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC50 0.5 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC50 1.0 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC90 0.5 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET MIC90 1.0 ug.mL-1 10.1128/aac.00845-09
None NON-PROTEIN TARGET MIC90 8.0 ug.mL-1 10.1128/aac.01260-08
None NON-PROTEIN TARGET Potency 1122.0 nM None
None NON-PROTEIN TARGET Potency 3162.3 nM None
None NON-PROTEIN TARGET Potency 4213.5 nM None
None NON-PROTEIN TARGET Potency 9432.9 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
None NON-PROTEIN TARGET Potency 17782.8 nM None
None NON-PROTEIN TARGET Ratio 49.0 None 10.1021/jm990079m
None NON-PROTEIN TARGET Safety ratio 0.4 None 10.1021/jm010131q
None NON-PROTEIN TARGET Safety ratio 1.8 None 10.1021/jm010131q
None NON-PROTEIN TARGET Safety ratio 37.0 None 10.1021/jm010131q
None NON-PROTEIN TARGET TGI nan None 10.1016/j.bmcl.2016.03.015
None No relevant target CLogP 0.484 None 10.1021/jm960491r
None No relevant target LogD -1.55 None 10.1021/jm00105a008
None No relevant target LogD -1.55 None 10.1021/jm00128a035
None No relevant target LogD -1.55 None 10.1021/jm00155a006
None No relevant target LogD -1.55 None 10.1021/jm00185a011
None No relevant target LogD -1.55 None 10.1021/jm00347a007
None No relevant target LogD 0.13 None 10.1021/jm0000564
None No relevant target LogD 0.63 None 10.1021/jm0100990
None No relevant target LogD 0.63 None 10.1021/jm8005228
None No relevant target LogD 0.67 None 10.1021/jm8005228
None No relevant target LogD 0.82 None 10.1021/jm00185a011
None No relevant target LogD 0.82 None 10.1021/jm00369a019
None No relevant target LogD 0.91 None 10.1021/jf102525e
None No relevant target LogD7.4 0.63 None 10.6019/CHEMBL3301361
None No relevant target LogP 0.82 None 10.1021/jm00347a007
None No relevant target LogP 0.89 None 10.1021/jm00394a012
None No relevant target LogP 0.91 None 10.1016/j.bmc.2007.03.040
None No relevant target LogP 0.91 None 10.1021/jf102525e
None No relevant target logPapp -5.5 None 10.1021/jf102525e
None No relevant target pKa 0.0 None 10.1021/jf102525e
None No relevant target pKa 7.07 None 10.1021/jm0200409
None No relevant target pKa 7.2 None 10.1021/jm0000564
None No relevant target pKa 7.26 None 10.1016/j.ejmech.2009.06.004
None No relevant target pKa 7.26 None 10.1021/jm030408h
None No relevant target pKa_B1 7.13 None 10.6019/CHEMBL3301361
None No relevant target solubility nan None 10.1016/j.ejmech.2014.12.051
None Phospholipidosis Phospholipidosis nan None 10.1080/15376510701857262
None Unchecked Ac50 1.413 uM None
None Unchecked Ac50 3.548 uM None
None Unchecked Ac50 7.943 uM None
None Unchecked Ac50 8.913 uM None
None Unchecked AC50 1412.5 nM None
None Unchecked AC50 3548.1 nM None
None Unchecked AC50 7943.3 nM None
None Unchecked AC50 8920.0 nM None
None Unchecked Activity 0.32 None 10.1021/jm061027h
None Unchecked Activity 0.5 10'-8M 10.1021/jm00211a020
None Unchecked Activity 14.0 uM 10.1016/j.bmc.2010.03.031
None Unchecked Activity nan None 10.1021/acs.jmedchem.9b01210
None Unchecked deltaG -10984.3 cal/mol 10.1016/j.ejmech.2021.113979
None Unchecked deltaH -1350.0 cal/mol 10.1016/j.ejmech.2021.113979
None Unchecked deltaS -8.4 cal/mol/deg 10.1016/j.ejmech.2021.113979
None Unchecked EC50 83000.0 nM 10.1016/j.ejmech.2017.04.070
None Unchecked EC50 100000.0 nM 10.1016/j.ejmech.2017.04.070
None Unchecked Hepatotoxicity (acute) 6.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 5.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.014 nM 10.1039/d0md00303d
None Unchecked IC50 0.02 nM 10.1039/d0md00303d
None Unchecked IC50 1.0 nM 10.1021/acs.jmedchem.1c01962
None Unchecked IC50 1.5 nM 10.1021/jm400086g
None Unchecked IC50 10.0 nM 10.1021/jm701052u
None Unchecked IC50 16.5 nM 10.1039/d0md00303d
None Unchecked IC50 20.0 nM 10.1016/j.bmcl.2017.02.018
None Unchecked IC50 20.0 nM 10.1021/jm070165j
None Unchecked IC50 25.7 nM 10.1128/aac.00377-09
None Unchecked IC50 55.0 nM 10.1128/aac.00384-08
None Unchecked IC50 61.6 nM 10.1016/j.ejmech.2021.113979
None Unchecked IC50 64.0 None 10.1021/jm070165j
None Unchecked IC50 92.0 nM 10.1016/j.bmcl.2019.06.004
None Unchecked IC50 120.0 nM 10.1016/j.bmcl.2019.06.004
None Unchecked IC50 120.0 nM 10.1021/jm400086g
None Unchecked IC50 150.0 nM None
None Unchecked IC50 300.0 nM 10.1021/jm800244v
None Unchecked IC50 560.0 nM None
None Unchecked IC50 675.0 nM None
None Unchecked IC50 820.0 nM None
None Unchecked IC50 870.0 nM None
None Unchecked IC50 2700.0 nM 10.1021/ml400208v
None Unchecked IC50 2900.0 nM 10.1021/jm9011142
None Unchecked IC50 3410.0 nM None
None Unchecked IC50 4130.0 nM None
None Unchecked IC50 4620.0 nM None
None Unchecked IC50 6800.0 nM 10.1021/jm701052u
None Unchecked IC50 7000.0 nM 10.1039/C3MD00104K
None Unchecked IC50 8000.0 nM 10.1039/d0md00303d
None Unchecked IC50 12920.0 nM 10.1016/j.ejmech.2021.113378
None Unchecked IC50 14000.0 nM 10.1016/j.bmcl.2008.11.054
None Unchecked IC50 14000.0 nM 10.1021/jm061027h
None Unchecked IC50 14000.0 nM 10.1039/C3MD00104K
None Unchecked IC50 25040.0 nM None
None Unchecked IC50 32997.0 nM 10.1128/aac.00377-09
None Unchecked IC50 50000.0 nM 10.1021/jm8006933
None Unchecked IC50 77000.0 nM 10.1039/C3MD00104K
None Unchecked IC50 88700.0 nM 10.1016/j.ejmech.2020.112268
None Unchecked IC50 125000.0 nM None
None Unchecked IC50 5000000.0 nM 10.1039/d0md00303d
None Unchecked IC50 nan None 10.1016/j.bmcl.2009.10.057
None Unchecked IC50 nan None 10.1016/j.bmcl.2012.02.019
None Unchecked IC50 nan None 10.1021/jm701052u
None Unchecked IFI 2.26 % 10.1038/nature09107
None Unchecked Inhibition 70.0 % 10.1016/j.ejmech.2014.12.051
None Unchecked Inhibition 100.0 % 10.1016/j.ejmech.2014.12.051
None Unchecked Inhibition 103.28 % 10.1016/j.ejmech.2021.113979
None Unchecked Inhibition nan % 10.1016/j.ejmech.2019.06.051
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Inhibition nan % 10.1128/aac.00384-08
None Unchecked Kd 8.7 nM 10.1016/j.ejmech.2021.113979
None Unchecked Ki 0.02 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 0.19 nM 10.1016/j.bmcl.2011.07.059
None Unchecked Ki 0.2 nM 10.1039/d0md00303d
None Unchecked Ki 4.4 nM 10.1039/d0md00303d
None Unchecked Ki 25.0 nM 10.1021/jm800694g
None Unchecked Ki 70.0 nM 10.1016/j.bmc.2019.04.032
None Unchecked Ki 380.0 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 450.0 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 500.0 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 660.0 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 810.0 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 1300.0 nM 10.1021/acsmedchemlett.0c00393
None Unchecked Ki 1500.0 nM 10.1039/d0md00303d
None Unchecked Ki 77233.0 nM 10.1016/j.bmc.2014.11.009
None Unchecked MIC 0.1 ug.mL-1 10.1016/j.bmcl.2009.10.057
None Unchecked MIC 1.0 ug.mL-1 10.1021/jm00128a043
None Unchecked Potency 707.9 nM None
None Unchecked Potency 819.6 nM None
None Unchecked Potency 5011.9 nM None
None Unchecked Ratio 11.0 None 10.1021/jm030312n
None Unchecked Ratio 11.1 None 10.1021/jm990079m
None Unchecked Ratio 22.4 None 10.1021/jm0202369
None Unchecked Ratio 49.0 None 10.1021/jm030312n
None Unchecked Ratio 54.6 None 10.1016/j.bmc.2019.04.032
None Unchecked Ratio 100.0 None 10.1021/jm0202369
None Unchecked Ratio 12000.0 None 10.1021/jm020495y
None Unchecked Ratio 17000.0 None 10.1021/jm0202369
None Unchecked Ratio IC50 1.7 None 10.1021/jm800776a
None Unchecked Ratio IC50 4.7 None 10.1016/j.bmc.2009.06.021
None Unchecked Ratio IC50 6.0 None 10.1021/jm00212a010
None Unchecked Ratio IC50 11.1 None 10.1021/jm800694g
None Unchecked Ratio IC50 14.0 None 10.1016/j.bmc.2009.11.029
None Unchecked Ratio IC50 14.0 None 10.1021/jm400086g
None Unchecked Ratio IC50 15.0 None 10.1021/acs.jmedchem.8b01754
None Unchecked Ratio IC50 15.0 None 10.1021/jm070165j
None Unchecked Ratio IC50 15.0 None 10.1021/jm800244v
None Unchecked Ratio IC50 37.5 None 10.1128/aac.00361-10
None Unchecked Ratio IC50 49.0 None 10.1021/jm800694g
None Unchecked Ratio IC50 49.0 None 10.1021/ml400208v
None Unchecked Ratio IC50 50.0 None 10.1021/jm701052u
None Unchecked Ratio IC50 50.0 None 10.1021/jm900490a
None Unchecked Ratio IC50 65.0 None 10.1016/j.bmc.2009.11.029
None Unchecked Ratio IC50 65.0 None 10.1016/j.bmc.2010.03.031
None Unchecked Ratio IC50 74.0 None 10.1039/C3MD00104K
None Unchecked Ratio IC50 234.0 None 10.1021/jm800244v
None Unchecked Ratio IC50 266.0 None 10.1016/j.bmc.2018.04.032
None Unchecked Ratio IC50 266.0 None 10.1016/j.bmcl.2019.06.004
None Unchecked Ratio IC50 268.0 None 10.1016/j.bmcl.2019.06.004
None Unchecked Ratio IC50 268.0 None 10.1021/jm400086g
None Unchecked Ratio IC50 600.0 None 10.1016/j.bmc.2010.03.031
None Unchecked Ratio IC50 600.0 None 10.1021/jm070165j
None Unchecked Ratio IC50 600.0 None 10.1021/jm800244v
None Unchecked Ratio IC50 610.0 None 10.1016/j.bmc.2009.11.029
None Unchecked Ratio IC50 34000.0 None 10.1021/jm070165j
None Unchecked Ratio IC50 34000.0 None 10.1021/jm800244v
None Unchecked Ratio IC50 120000.0 None 10.1021/jm400086g
None Unchecked Ratio IC50 1000000.0 None 10.1021/jm201645r
None Unchecked Ratio Ki 1.8 None 10.1021/jm100727t
None Unchecked Ratio Ki 6.0 None 10.1016/j.ejmech.2017.04.070
None Unchecked Ratio Ki 12.3 None 10.1128/aac.00361-10
None Unchecked Ratio Ki 50.2 None 10.1021/jm100727t
None Unchecked Ratio Ki 69.0 None 10.1021/acs.jmedchem.6b00688
None Unchecked Ratio Ki 130.0 None 10.1021/acs.jmedchem.6b00688
None Unchecked Ratio Ki 15000.0 None 10.1016/j.bmcl.2011.07.059
None Unchecked Ratio Ki 15400.0 None 10.1021/jm401204g
None Unchecked Ratio Ki 1000000.0 None 10.1021/jm201645r
None Unchecked Selectivity 9.8 None 10.1021/jm00024a001
None Unchecked Selectivity 11.0 None 10.1021/jm950918e
None Unchecked Selectivity 48.0 None 10.1021/jm950918e
None Unchecked Selectivity index 0.11 None 10.1021/jm00006a016
None Unchecked Selectivity index 2.9 None 10.1021/jm970776j
None Unchecked Selectivity index 11.0 None 10.1021/jm980572i
None Unchecked Selectivity index 78.0 None 10.1021/jm980572i
None Unchecked Selectivity index 610.0 None 10.1021/jm020466n
None Unchecked Selectivity index 610.0 None 10.1021/jm0581718
None Unchecked Selectivity ratio 1.32 None 10.1016/j.ejmech.2019.111765
None Unchecked Selectivity ratio 1.4 None 10.1016/j.ejmech.2019.111765
None Unchecked Selectivity ratio 4.0 None 10.1021/jm201645r
None Unchecked Selectivity ratio 11.0 None 10.1021/jm970399a
None Unchecked Selectivity ratio 11.0 None 10.1021/jm970614n
None Unchecked Selectivity ratio 11.0 None 10.1021/jm990331q
None Unchecked Selectivity ratio 11.1 None 10.1021/jm00012a016
None Unchecked Selectivity ratio 11.1 None 10.1021/jm9705420
None Unchecked Selectivity ratio 48.0 None 10.1021/jm970399a
None Unchecked Selectivity ratio 48.0 None 10.1021/jm970614n
None Unchecked Selectivity ratio 48.0 None 10.1021/jm990331q
None Unchecked Selectivity ratio 49.0 None 10.1021/jm00012a016
None Unchecked Selectivity ratio 49.0 None 10.1021/jm9705420
None Unchecked Selectivity ratio 680.0 None 10.1021/jm990331q
None Unchecked SI 2.9 None 10.1021/jm00105a008
None Unchecked SI 4.1 None 10.1021/jm00105a008
None Unchecked SI 6.88 None 10.1021/jm00105a008
None Unchecked SI 14.0 None 10.1021/jm030599o
None Unchecked SI 20.0 None 10.1021/jm030599o
None Unchecked SI 60.0 None 10.1021/jm030438k
None Unchecked SI 65.0 None 10.1021/jm030599o
None Unchecked SI 330.0 None 10.1021/jm030599o
None Unchecked SI 610.0 None 10.1021/jm030599o
None Unchecked Survival 69.0 % 10.1016/j.ejmech.2019.06.051
None Unchecked Survival 99.0 % 10.1016/j.ejmech.2019.06.051

Metabolism Information