Cinnabaramide D
AlkaPlorer ID: AK012532
Synonym: None
IUPAC Name: (2R,3S,4R)-2-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-3-hydroxy-4-(1-hydroxyhexyl)-3-methyl-5-oxopyrrolidine-2-carboxylic acid
Structure
SMILES: CCCCCC(O)[C@H]1C(O)=N[C@](C(=O)O)([C@@H](O)[C@@H]2C=CCCC2)[C@@]1(C)O
InChI: InChI=1S/C19H31NO6/c1-3-4-6-11-13(21)14-16(23)20-19(17(24)25,18(14,2)26)15(22)12-9-7-5-8-10-12/h7,9,12-15,21-22,26H,3-6,8,10-11H2,1-2H3,(H,20,23)(H,24,25)/t12-,13?,14+,15+,18+,19+/m1/s1
InChIKey: HZMVPYGKRJDSSJ-MOEJHERCSA-N
Reference
Cinnabaramides A−G: Analogues of Lactacystin and Salinosporamide from a Terrestrial Streptomycete
PubChem CID: 16109812
LOTUS: LTS0019644
NPASS: NPC473224
{NPAtlas: NPA013041
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 369.4580000000002
TPSA？: 130.58
MolLogP？: 1.8055
Number of H-Donors: 5
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | 20S proteasome | IC50 | 100.0 | nM | 10.1021/np060162u |
| Homo sapiens | Trypsin | Activity | nan | None | 10.1021/np060162u |
| None | Unchecked | Activity | nan | None | 10.1021/np060162u |