O-Methylsciadenine
AlkaPlorer ID: AK013128
Synonym: '(-)-Cycleanine', 'Cycleanine'
IUPAC Name: (11S,26S)-4,5,19,20-tetramethoxy-10,25-dimethyl-2,17-dioxa-10,25-diazaheptacyclo[26.2.2.213,16.13,7.118,22.011,36.026,33]hexatriaconta-1(31),3(36),4,6,13,15,18(33),19,21,28(32),29,34-dodecaene
Structure
SMILES: COC1=CC2=C3C(=C1OC)OC1=CC=C(C=C1)C[C@H]1C4=C(C=C(OC)C(OC)=C4OC4=CC=C(C=C4)C[C@@H]3N(C)CC2)CCN1C
InChI: InChI=1S/C38H42N2O6/c1-39-17-15-25-21-31(41-3)35(43-5)37-33(25)29(39)19-23-7-11-28(12-8-23)46-38-34-26(22-32(42-4)36(38)44-6)16-18-40(2)30(34)20-24-9-13-27(45-37)14-10-24/h7-14,21-22,29-30H,15-20H2,1-6H3/t29-,30-/m0/s1
InChIKey: ANOXEUSGZWSCQL-KYJUHHDHSA-N
Reference
Two New Isochondodendrine-Type Alkaloids from the Roots of <i>Anisocycla jollyana</i>
PubChem CID: 12305350
LOTUS: LTS0233314
SuperNatural Ⅲ: SN0010381-01
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Anisocycla jollyana | Anisocycla | Menispermaceae | Ranunculales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 622.762
TPSA？: 61.860000000000014
MolLogP？: 7.16240000000001
Number of H-Donors: 0
Number of H-Acceptors: 8
RingCount: 10
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli | Escherichia coli | AC50 | 25159.0 | nM | None |
| Homo sapiens | Ataxin-2 | Potency | 15848.9 | nM | None |
| Homo sapiens | DNA dC->dU-editing enzyme APOBEC-3F | Potency | 35481.3 | nM | None |
| Homo sapiens | DNA polymerase iota | Potency | 100000.0 | nM | None |
| Homo sapiens | Geminin | Potency | 2592.9 | nM | None |
| Homo sapiens | Geminin | Potency | 29092.9 | nM | None |
| Homo sapiens | Glucagon-like peptide 1 receptor | Potency | 5623.4 | nM | None |
| Homo sapiens | GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | Potency | 2592.9 | nM | None |
| Homo sapiens | HepG2 | Potency | 7943.3 | nM | None |
| Homo sapiens | Lysine-specific demethylase 4A | Potency | 50118.7 | nM | None |
| Homo sapiens | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Potency | 19952.6 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 16360.1 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 18356.4 | nM | None |
| Homo sapiens | Ubiquitin carboxyl-terminal hydrolase 1 | Potency | 8912.5 | nM | None |
| Rattus norvegicus | Thioredoxin reductase 1, cytoplasmic | Potency | 89125.1 | nM | None |
| None | Unchecked | Potency | 6309.6 | nM | None |
| None | Unchecked | Potency | 8912.5 | nM | None |
| None | Unchecked | Potency | 39810.7 | nM | None |