Molecule

erythro-4-hydroxy-L-glutamate(1-)

AlkaPlorer ID: AK013470

Synonym: 'erythro-4-hydroxy-L-glutamic acid', '(2S,4R)-2-amino-4-hydroxypentanedioic acid', 'erythro-4-hydroxy-L-glutamate', 'L-erythro-4-hydroxyglutamic acid', '(2S,4R)-2-ammonio-4-hydroxypentanedioate'

IUPAC Name: (2S,4R)-2-amino-4-hydroxypentanedioic acid

Structure

SMILES: N[C@@H](C[C@@H](O)C(=O)O)C(=O)O

InChI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1

InChIKey: HBDWQSHEVMSFGY-STHAYSLISA-N

Reference

gamma-Hydroxyglutaminsäure in Linaria vulgaris Miller.

PubChem CID: 440854

CAS: 2485-33-8

LOTUS: LTS0112925

SuperNatural Ⅲ: SN0120802-04

NPASS: NPC323920

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Saccharomyces cerevisiae	Saccharomyces	Saccharomycetaceae	Saccharomycetales	Saccharomycetes	Ascomycota	Fungi	Eukaryota

Properties Information

Molecule Weight: 163.129

TPSA？: 120.85

MolLogP？: -1.7660999999999991

Number of H-Donors: 4

Number of H-Acceptors: 4

RingCount: 0

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	Excitatory amino acid transporter 1	Km	1000000.0	nM	10.1021/jm050597z
Homo sapiens	Excitatory amino acid transporter 1	pKm	3.0	None	10.1021/jm050597z
Homo sapiens	Excitatory amino acid transporter 2	Km	1000000.0	nM	10.1021/jm050597z
Homo sapiens	Excitatory amino acid transporter 2	pKm	3.0	None	10.1021/jm050597z
Homo sapiens	Excitatory amino acid transporter 3	Km	1000000.0	nM	10.1021/jm050597z
Homo sapiens	Excitatory amino acid transporter 3	pKm	3.0	None	10.1021/jm050597z
Rattus norvegicus	Metabotropic glutamate receptor 1	EC50	373000.0	nM	10.1016/s0960-894x(01)00158-5
Rattus norvegicus	Metabotropic glutamate receptor 1	Rmax	70.0	mM	10.1016/s0960-894x(01)00158-5
Rattus norvegicus	Metabotropic glutamate receptor 2	EC50	161000.0	nM	10.1016/s0960-894x(01)00158-5
Rattus norvegicus	Metabotropic glutamate receptor 2	Rmax	52.0	mM	10.1016/s0960-894x(01)00158-5
Rattus norvegicus	Metabotropic glutamate receptor 8	EC50	69000.0	nM	10.1016/s0960-894x(01)00158-5
Rattus norvegicus	Metabotropic glutamate receptor 8	Rmax	54.0	mM	10.1016/s0960-894x(01)00158-5

Metabolism Information

AKRT ID	Reaction	Reaction Link ID
AKRT018685	N[C@@H](CC(=O)O)C(=O)O.O=C(O)C(=O)CC(O)C(=O)O>>N[C@@H](C[C@@H](O)C(=O)O)C(=O)O	MNXR97909
AKRT019694	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O.O=C(O)CC(=O)C(=O)O>>N[C@H](CC(=O)O)C(=O)O	R05053
AKRT019695	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O.O=C(O)CC(=O)C(=O)O>>O=C(O)C(=O)CC(O)C(=O)O	MNXR134505
AKRT019696	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O.O=C(O)CC(=O)C(=O)O>>O=C(O)C(=O)C[C@@H](O)C(=O)O	R05053
AKRT019697	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O.O=C(O)CCC(=O)C(=O)O>>N[C@@H](CCC(=O)O)C(=O)O	4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN
AKRT019698	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O.O=C(O)CCC(=O)C(=O)O>>O=C(O)C(=O)C[C@@H](O)C(=O)O	4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN
AKRT019699	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O>>N[C@@H](CCC(=O)O)C(=O)O	enzymemap_41864
AKRT019700	N[C@@H](C[C@@H](O)C(=O)O)C(=O)O>>O=C(O)[C@@H]1C[C@@H](O)C=N1	MNXR179359
AKRT019701	N[C@@H](C[C@@H](O)C=O)C(=O)O>>N[C@@H](C[C@@H](O)C(=O)O)C(=O)O	RXN-14472
AKRT023044	O=C(O)[C@@H]1C[C@@H](O)C=N1>>N[C@@H](C[C@@H](O)C(=O)O)C(=O)O	HYDROXYPYRROLINEDEH-RXN